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Research Highlights
Research Highlights
Read the selected grantee publications.
Profile of a Veterinary Anatomic Pathologist and Researcher: Heather Shive, D.V.M., Ph.D., DACVP
Since her childhood, Dr. Heather Shive has been interested in working with animals. This interest, combined with a love of scientific...
Posted Date: December 5, 2023
Hartford Hospital Uses ARRA Funds to Perform Interdisciplinary Research in Neuropsychiatry
An estimated 200,000 people undergo bariatric surgery—commonly known as weight-loss surgery—in the United States annually, according to the American...
Posted Date: November 2, 2023
ORIP Funds Research to Advance Large Animal Models Using Stem Cell Transplantation
Many biomedical researchers use animal models to better understand diseases that occur in humans. Transplantation of testis stem cells—the foundation...
Posted Date: October 2, 2023
Supercomputing Technologies Funded by ORIP Helped Spur Approval of COVID-19 Vaccines and Save Lives
Supercomputing has been gaining attention for its applications across biomedical research. A type of high-performance computing...
Posted Date: September 26, 2023
ARRA Funds Enhance Training Opportunities in Neurological Research
Composed of 86 billion neurons and an array of intricate structures, the human brain is a complex organ that regulates every process within the body.
Posted Date: September 1, 2023
ORIP Diversity Supplement Awards Helped a Young Investigator Advance His Career in Biomedical Research and Will Allow Him to Give Back to His Community
Dr. Corbin Schuster’s interest in biomedical research began during his undergraduate training, when he completed a 10-week internship at the National...
Posted Date: August 1, 2023
NIH ARRA Program Funds Infrastructure for Modern Nonhuman Primate Research
Many people today use touchscreen devices to manage or control various aspects of their lives, such as food deliveries, home lighting, and video entertainment.
Posted Date: July 3, 2023
Profile of a Promising Environmental Health Scholar: Tracie Baker, D.V.M., Ph.D.
An environmental toxicologist, principal investigator, and director of the Warrior Aquatic, Translational, and Environmental Research (WATER)...
Posted Date: June 1, 2023
ARRA-Funded Rutgers Repository Pivots to COVID-19 Testing During Pandemic
In 2010, the Rutgers University Cell and DNA Repository (RUCDR) was awarded nearly $10 million (C06RR030323) to renovate space for a core facility...
Posted Date: May 1, 2023
An Interdisciplinary Team Assembled to Preserve Aquatic Genetic Resources and to Develop Capacity Building at Resource Center Cryo-Repositories
Researchers use a diverse array of aquatic organisms—such as fish, amphibians, and invertebrates—to explore various biological questions.
Posted Date: April 3, 2023
ORIP-Funded Veterinary Scientist Studies Disease Dynamics in Uganda
Mosquitoes are pervasive around the globe, with more than 3,000 species across all continents except Antarctica. Many people regard these insects as...
Posted Date: February 1, 2023
NIH ARRA Investment Funds State-of-the-Art Core Facility to Support the Future of RNA Medicine at Beth Israel Deaconess Medical Center
Dr. Frank Slack, Director of the Harvard Medical School Initiative for RNA Medicine (HIRM), envisions a promising future for RNA-based therapeutics...
Posted Date: January 4, 2023
ORIP Support for Small Businesses Leads to New Commercial Technology Outcomes That Benefit Community Resources and Advance Research Discoveries
ORIP participates in two federal grant programs that provide funding to small businesses: the Small Business Innovation Research (SBIR) program and...
Posted Date: December 1, 2022
ARRA Program Helps Enable Revolutionary Discoveries in Gene Therapy
Located within the heart of the Children’s Hospital of Philadelphia (CHOP) Research Institute, the Clinical Vector Core (CVC) fills a unique role...
Posted Date: November 1, 2022
Mirindi Kabangu: Diversity Supplement Award Helps Scholar Jumpstart His Dream Career
For much of his life, Mr. Mirindi Kabangu has held a passion for learning. As an undergraduate student, this passion led him to the laboratory of Dr...
Posted Date: October 3, 2022
Profile of a Promising HIV/AIDS Scholar: Riti Sharan, Ph.D.
As an immunologist studying HIV, latent tuberculosis infection (LTBI), and possible treatments, Dr. Riti Sharan (Figure 1) has been intrigued by the...
Posted Date: September 6, 2022
Mouse Research Yields New Insights on Mendelian Disease Genetics
Gregor Mendel’s work in the 19th century laid the foundation for our current understanding of heritability—the ways in which phenotypes (i.e., an individual’s observable traits) are...
Posted Date: August 1, 2022
Gnotobiotic Mouse Resources Support Studies of Microbial Interactions
Microorganisms affect nearly every aspect of life, regulating numerous biological processes at the ecosystem and organismal levels. All multi-organ...
Posted Date: July 1, 2022
S10 Instrumentation Programs Enhance Capabilities for Proteomics Research at Cleveland Clinic’s Lerner Research Institute
Understanding the molecular composition and structure of proteins is essential to the mechanistic study of human health and diseases and requires the...
Posted Date: June 1, 2022
Reproducibility of Rodent Models for Human Disease: MiniMUGA as a Critical Genetic Tool
Mice are a crucial resource for the scientific community. Scientific researchers from numerous disciplines use the mouse as a model to mimic and...
Posted Date: May 2, 2022
Pervasive Effects of COVID-19 on the Brain of Nonhuman Primates
In an article published today in Nature Communications, a team of scientists from the Tulane National Primate Research Center (TNPRC) reported the first...
Posted Date: April 1, 2022
S10 Instrumentation Programs Enhance Use of Cryo‑EM Technologies for COVID‑19 Research
Cryogenic electron microscopy (cryo-EM) can offer unique insights on biological molecules, enabling investigators to piece together complex structures.
Posted Date: March 1, 2022
Nonhuman Primate Study Demonstrates the Value of ORIP-funded Resources for COVID-19 Research
A recent study by a team of researchers at the Southwest National Primate Research Center (SNPRC) and Texas Biomedical Research Institute, in...
Posted Date: February 4, 2022
A New Method for
Drosophila
Cryopreservation Overcomes Longstanding Challenges
For biologists, cryopreservation holds major potential for numerous areas of research. The process of vitrifying (i.e., storing in glass to avoid the...
Posted Date: January 3, 2022
S10-funded Microscopes Propel UT Southwestern Facilities to the Forefront of Research
Imaging plays a pivotal role in deciphering the molecular pathways of human physiology and pathophysiology. At The University of Texas Southwestern...
Posted Date: December 1, 2021
National Primate Research Centers Address Rigor and Reproducibility Challenges
In recent years, scientists have grown increasingly aware of the importance of conducting research that is both rigorous and reproducible. The need...
Posted Date: November 1, 2021
Microscope Funded by S10 Program Advances Biological Research at the University of Delaware
Located within the heart of the Delaware Biotechnology Institute Bio-Imaging Center , the Zeiss LSM 880 inverted laser scanning confocal microscope...
Posted Date: October 1, 2021
Cell Ablation System in Zebrafish Yields Insights on Cellular Regeneration
The zebrafish (Danio rerio) has been used by researchers as a model organism for human disease for decades. In recent years, however, the zebrafish has gained considerable...
Posted Date: September 1, 2021
Safeguarding the Valuable Genetic Stock Collections of Public Repositories
The National Institutes of Health (NIH) Office of Research Infrastructure Programs (ORIP) supports many resource centers that develop animal models for research.
Posted Date: August 16, 2021
ORIP Supports the Scientific Career of a Promising Young Investigator Studying Parasitic Infections in Zebrafish
Mr. Corbin Schuster’s interest in biomedical research began with a 10-week internship at the National Institute of Diabetes and Digestive and Kidney...
Posted Date: July 30, 2021
Flow Cytometer at West Virginia University Supports Research Across Disciplines
A state-of-the-art flow cytometer awarded to West Virginia University (WVU) in 2013 has helped investigators make scientific advances across a...
Posted Date: July 15, 2021
ORIP Publishes Third and Fourth Commentaries in
Nature Lab Animal
Series on SARS-CoV-2 Research Using Nonhuman Primate Models
The SARS-CoV-2 pandemic has significantly increased demand for the nonhuman primate (NHP) research needed to develop vaccines and treatments for...
Posted Date: June 28, 2021
Cryo-Electron Microscopy Used to Bridge the Micro-Nano Gap
To understand human physiology and the pathology of diseases, it is important to investigate the underlying biological processes on all spatial...
Posted Date: June 15, 2021
Zika Virus Vaccine Looks Promising To Prevent Mother-to-Fetus Transmission
In 2015 and 2016, the Zika virus outbreak in South America surprised the global community. In pregnant women, the virus led to a high rate of fetal...
Posted Date: June 1, 2021
The WormGUIDES Atlas: A Window into the Mysteries of Neurodevelopment in
Caenorhabditis elegans
More than 30 years after the adult nervous system and cell lineage of the roundworm Caenorhabditis elegans were first mapped, 1 that map of neuron...
Posted Date: May 14, 2021
ORIP Publishes Two Commentaries in
Nature Lab Animal
on Nonhuman Primate Models for SARS-CoV-2 Research
The SARS-CoV-2 pandemic has significantly increased the demand for both nonhuman primates (NHPs), the preclinical model most predictive of disease...
Posted Date: April 30, 2021
Profile of a Veterinary Scientist: Xuan Pan, V.M.D., Ph.D., DACVIM
For as long as she can remember, Dr. Xuan Pan had dreamed of a career in veterinary medicine. A long-time animal lover who grew up with pets in her household...
Posted Date: April 30, 2021
Mutant Mouse Research & Resource Center at the University of Missouri Furthers Model Development for the Community
Laboratory mice are an essential resource for the scientific community. The mouse genome can be manipulated easily, allowing researchers to induce...
Posted Date: April 15, 2021
California National Primate Research Center Team Develops Novel Tau Model for Alzheimer's Disease in a Nonhuman Primate
Alzheimer’s disease (AD) affects more than 5.5 million Americans per year . The earliest symptoms of AD, however, often occur after decades of...
Posted Date: March 18, 2021
The Amazing Axolotl: A Valuable Model for Regenerative Medicine
Axolotls (Ambystoma mexicanum) are salamanders that have been used for research for more than 200 years (Figure 1).1 They have a remarkable ability to regenerate...
Posted Date: March 16, 2021
New Initiatives for Outreach to Support Small Business Entrepreneurs' Dreams
The Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs are congressionally mandated initiatives...
Posted Date: March 1, 2021
Promising One-Dose Rapid Treatment for Newborns to Prevent Lifelong Infection with HIV
Newborns can be exposed to HIV—the virus that causes AIDS—during gestation, birth, or breastfeeding. In general, babies born to mothers who test...
Posted Date: February 16, 2021
Seeing Sound: UCSD Researchers Study Biology in a Whole New Light
Jesse V. Jokerst, Ph.D. Associate Professor, Department of NanoEngineering Affiliate Faculty, Materials Science Program Adjunct Faculty, Department...
Posted Date: February 1, 2021
A Drug Discovery Platform To Rapidly Diagnose Patients
Precision disease modeling has gained increased interest in the research community in recent years and remains at the forefront of personalized...
Posted Date: January 15, 2021
K01 Awardee Studies Innovative Approaches to Induce Protective Immunity Against HIV
Dr. Mauricio Martins has long been fascinated by the complexity of human immunodeficiency virus (HIV) and its relevance to public health. “The virus…...
Posted Date: January 8, 2021
Swift Efforts Are Underway To Distribute a Mouse Model for COVID-19 Research
The current COVID-19 pandemic in humans, caused by the novel coronavirus strain SARS-CoV-2, has compelled scientists around the world to work...
Posted Date: December 8, 2020
New Visualization Method Gets to the Heart of Parkinson's Disease
Parkinson's disease (PD), the second most common progressive neurodegenerative disorder affecting U.S. adults over the age of 60, is predicted to...
Posted Date: December 8, 2020
Profile of a Veterinary Scientist: Meghan Davis, D.V.M., Ph.D., M.P.H.
Interactions between humans and companion animals have been shown to produce mental, social, and physiological benefits in children and adults . Therapy dogs, for example, can provide individually tailored support for patients .
Posted Date: December 7, 2020
Animal Models and Resources for Coronavirus Research
The National Institutes of Health (NIH) Office of Research and Infrastructure Programs (ORIP) aims to provide investigators with the resources and...
Posted Date: September 22, 2020
Nonhuman Primate Researchers Push to Support Biomarker Validation Across Community
Biomedical research has been transformed over the past several decades; new capabilities that researchers once only dreamed of are now possible. As a...
Posted Date: April 14, 2020
ORIP Nonhuman Primates Resources
ORIP’s DCM supports multiple NHP colonies and research-related resources that are available to the research community. These NHP Resources support...
Posted Date: March 26, 2020
Macaques, Humans, and Genomes: mGAP - A New Genetic Webtool To Discover Natural Occurring Diseases in Macaques
At the Oregon National Primate Research Center (ONPRC), a group of monkeys climb and swing across their large outdoor enclosure. At first glance, the...
Posted Date: March 23, 2020
Micro-CT: A view into the structure of life for the analysis of tissue phenotypes
A convergence of scientific breakthroughs in chemistry, optics, and engineering in the early 1800s resulted in a miraculous new way to understand...
Posted Date: October 28, 2019
Training and Diversifying the Biomedical Workforce
Growing up, Dr. Raquel Salinas did not believe that someone like her could turn a passion for science into a career. It was the classes she...
Posted Date: June 11, 2019
Immune Compromised Zebrafish: A Versatile and Cost-Effective Xenograft Model
Cell transplantation studies using immune compromised animals have advanced our understanding of the generation of immune cells, stem cell biology,...
Posted Date: April 16, 2019
Severe Combined Immunodeficient Pigs: A Promising Model for Human Stem Cell Therapy
Immunodeficient animals play an important role in biomedical research by allowing the examination of engrafted human cells under in vivo conditions,...
Posted Date: January 14, 2019
Nonhuman Primate Evaluation and Analysis Part 2: Report of the Expert Panel Forum on Challenges in Assessing Nonhuman Primate Needs and Resources for Biomedical Research
To augment and expand upon the findings of the Nonhuman Primate Evaluation and Analysis Part 1: Analysis of Future Demand and Supply of the study,...
Posted Date: December 19, 2018
Precision Health and Personal Omics
Implementation of precision health has the potential to revolutionize the current paradigm of modern medicine, which is still predominantly focused...
Posted Date: October 17, 2018
Nonhuman Primate Evaluation and Analysis Part 1: Analysis of Future Demand and Supply
Nonhuman primates (NHPs) serve as critical animal models for many research areas, including infectious diseases; social, cognitive and behavioral...
Posted Date: October 12, 2018
Super-Resolution Imaging: Beating the Boundaries of Light
Substance use disorders and neuropsychiatric conditions are brain diseases characterized by morphological and functional adaptations in neurons and...
Posted Date: October 12, 2018
Revealing Pulmonary Structure and Function with Hyperpolarized Magnetic Resonance Imaging
Magnetic resonance imaging (MRI) is a common tool used to study the structure and function of bodily tissues in health and disease. Although MRI has...
Posted Date: July 10, 2018
Collaborative Data Sharing of Non-Human Primate (NHP) Research Reveals Increased Fetal Loss During Zika Virus (ZIKV) Infection
The National Primate Research Centers (NPRCs) 1 Consortium is a collaboration among the California (CNPRC), Oregon (ONPRC), Southwest (SNPRC), Tulane...
Posted Date: July 3, 2018
A Network Resource for Non-Human Primate Research
Research with non-human primates (NHPs) 1–4 is significant to our understanding of how the human body responds to diseases, some forms of cancers,...
Posted Date: May 29, 2018
A Veterinary Scientist’s Success Story — Dr. Carrie Finno, D.V.M., Ph.D.
“Veterinary researchers bring a unique perspective and training to the medical field that complements the training of physicians and Ph.D. basic...
Posted Date: April 4, 2018
Reshaping One of Nature’s Most Complex Defense Mechanisms to Help Fight Diseases
Biomedical research with non-human primates (NHPs) has resulted in several notable medical breakthroughs. 1–5 NHP research has been essential to our...
Posted Date: February 9, 2018
“Going with the Flow”—Biological Cell Sorting
Many of the scientific discoveries require an understanding of specialized biological processes at the cellular level. Scientists rely on the use of...
Posted Date: October 31, 2017
Solving the Mystery of Crystalline Protein Structures
Although X-ray crystallography was invented more than 100 years ago, it is still one of the most powerful techniques used to determine the three-...
Posted Date: October 31, 2017
A 4D Atlas for Studying Cell Development in Worms
For more than 50 years, scientists have used the roundworm Caenorhabditis elegans ( C. elegans )—a hermaphroditic nematode that is widely recognized...
Posted Date: October 31, 2017
Bioengineering Mouse Genomes to Advance Research and Precision Medicine. It’s Not Science Fiction
Each year, billions of dollars are spent on studying human diseases. Most science experts will agree that the use of laboratory animals is essential...
Posted Date: October 31, 2017
Taking Steps Forward—Advancing Conventional Methods of Medical CT Imaging
Since the 1970s, the field of medicine has relied on the imaging technique of X-ray computed tomography (CT) to visualize soft tissues of the body,...
Posted Date: October 30, 2017
A Go-To Resource Center for Zebrafish Researchers
Since making its debut as a research organism in the late 1970s, the humble zebrafish—an unassuming, pinky-sized striped fish originally found in the...
Posted Date: October 30, 2017
Resource Identification Initiative
Standardized labeling of resources will improve the reproducibility in biomedical research.
Posted Date: January 23, 2017
Public Data Sharing
Open-Lab Notebook enables rapid, collaborative response to Zika virus research questions.
Posted Date: January 23, 2017
Precision Disease Modeling
The era of personalized medicine is being realized through the testing of therapies on animal avatars.
Posted Date: January 23, 2017
Animal Models
Biobanks seek to reduce the hidden variables in animal resources that can affect experimental results.
Posted Date: October 14, 2016
Careers in Translational Research
ORIP grant programs enable veterinarians to participate in biomedical research.
Posted Date: October 14, 2016
Infectious Disease Research
Mutant mouse strains enable scientists to study pathogens as they interact with the human immune system.
Posted Date: October 14, 2016
Last updated: 03-16-2021
