Division of Construction and Instruments

ORIP’s Division of Construction and Instruments (DCI) supports research infrastructure in three areas: the S10 Instrumentation Programs (acquisition of state-of-the-art research instruments), the S15 Equipment Program (acquisition of modern research or auxiliary equipment to enhance operations of shared-use biomedical research facilities, formerly under the R24 activity code), and Extramural Construction Programs (construction and modernization of research facilities).

For more information on the S10 and S15 programs, view DCI's fact sheets:

C06 Extramural Construction Programs

S10 Instrumentation Programs

S15 Equipment Program

DCI Funding Opportunities

DCI Awards

New S10 Publications

DCI News and Research Highlights

S10 symposium. April 23-24, 2026. Office of Research Infrastructure Programs.

Mark your calendar and register: S10 Symposium

This 2-day symposium will highlight new S10 funding opportunities; offer useful tips on writing a successful S10 application; and share know-hows on reporting requirements, instrument operation, management, and administration by distinguished S10 awardees.

Dr. Eric A. Hoffman (right), Advanced Pulmonary Physiomic Imaging Laboratory (APPIL) Director, and Dr. Jessica C. Sieren (left), APPIL Deputy Director.

Seeing the Invisible: Detecting Early Lung Diseases with Advanced Computed Tomographic Imaging

For decades, physicians have relied on spirometry to detect chronic obstructive pulmonary disease (COPD). However, the global metrics derived from spirometry (a noninvasive breathing test) cannot sense regional lung damage in early disease.

NMR of bacterial extracellular vesicles reveals pH-driven conformational change of the Salmonella surface protein PagC.

Structural Studies In Situ Show How Bacteria Infect Humans, Leading to Chronic Diseases

Understanding the biological mechanisms that support human health and drive disease is essential for developing preventive and curative therapeutics. Direct structural analyses of proteins in their native environment are even more important.

Germ-free breeding cages in a gnotobiotic mouse facility.

NIH-Funded Gnotobiotic Facility Advances Microbiome Research in Chronic Liver Diseases and Obese Conditions at the University of California, San Diego

Many areas of biological research—including immunology, metabolic disorders, neurology, infectious disease, cancer, and translational microbiome research—require a well-controlled environment to study the role of the microbiome and host–microbe interactions.

S10 Mass Spectrometers Accelerate Collaborations on Aging and Women’s Health Research

Scientific and health innovations rely on continuous access to cutting-edge technology and instruments. Dr. Birgit Schilling, Professor, Buck Institute for Research on Aging, and Director of the Proteomics Core and Mass Spectrometry Center, knows this better than most.

Architecture and antigenicity of the PRD-0038 S trimer

New S10 Publications

This list of recent publications is sourced from PubMed and has been curated. For an exhaustive list please visit PubMed.

Author List	Title	Journal Title	Publication Date
Halide Bilge Türközer,Victor Zeng,Dung Hoang,Jothini Sritharan,Neha Iska,Elena I Ivleva,Brett A…	Neuroanatomical Deficits in Visual Cortex Subregions of Individuals With Psychosis Spectrum Disorders Linked to Symptoms, Cognition, and Childhood Trauma	Schizophrenia bulletin	2026-03-21
Eun-Ryeong Hahm,Bruce L Jacobs,Krishna B Singh,Su-Hyeong Kim,Rahul A Parikh,Daniel P Normolle,Rajiv…	Bench-to-Bedside Evaluation of Sulforaphane/BroccoMax on Fatty Acid Synthesis in Prostate Cancer	Cancer prevention research (Philadelphia, Pa.)	2026-03-19
Neil Carleton,Alexander C Chang,Fangyuan Chen,Shannon L Puhalla,Julia Foldi,Hunter Waltermire…	Use of ctDNA in Older Women with ER+ Breast Cancer to Facilitate Surgical De-escalation: A Prospective, Hybrid-Decentralized Trial with Correlative Studies	Clinical cancer research : an official journal of the American Association for Cancer Research	2026-03-19
Emily Klemm,Eric Gibbs,Madeleine Stauffer,Devesh Mohapatra,Chloe Meyer,Sudha Chakrapani	Human GlyRα2 pore dynamics in gating and inhibition	Structure (London, England : 1993)	2026-03-19
Paige C Arneson-Wissink,Katherine Pelz,Beth Worley,Heike Mendez,Peter Pham,Parham Diba,Peter R…	Impaired Adipose Anabolism in Pancreatic Cancer Cachexia Is Reversed by HuR Inhibition	Journal of cachexia, sarcopenia and muscle	2026-03-19