Extramural Construction Programs

ORIP's Division of Construction and Instruments (DCI) supports programs that fund the construction, renovation, and modernization of research space by issuing Notices of Funding Opportunities (NOFOs) when congressional appropriations are available.

The overall objective of these programs is to provide modernized physical infrastructure that meets up-to-date engineering requirements to conduct cutting-edge NIH-funded biomedical research. Such an investment in infrastructure offers long-term benefits because federally funded space must be used to support biomedical research for the next 10 years, depending on the regulatory requirement of an individual program. These investments impact research funded by essentially all NIH Institutes and Centers, benefiting all areas of biomedical sciences from fundamental biology to clinical translational research.

ORIP oversees the use of more than 300 research facilities in 45 states and in Puerto Rico that were funded in the last 20 years. These facilities provide new laboratory space, and set up environments for specialized research protocols and clinical investigations. For example, special facilities support antibody engineering for the development of cancer therapeutics and the synthesis of probes for positron emission tomography. The projects created designated space, such as barrier facilities to study pathogens and prions, animal facilities in nonhuman primate research centers to research infectious diseases, and shielded rooms for magnetic resonance imaging.

Active C06 NOFO

PAR-26-106 “Development of Collaborative Research Facilities or Research-Resource Facilities (C06 Clinical Trial Not Allowed)”

This NOFO supports two existing construction programs: the Biomedical Research Facilities (BRF) program and the HIV/AIDS Research Facilities (HRF) program.

Award Budget

BRF: $2M to $8M
HRF: $2M to $4M

Application Due Dates	Review and Award Cycles
New Submission	Scientific Merit Review	Advisory Council Review	Earliest Start Date
April 6, 2026	June 2026	October 2026	December 2026
January 25, 2027	June 2027	October 2027	December 2027
January 25, 2028	June 2028	October 2028	December 2028