Supported Programs and Mechanisms
Investigator-Initiated Research Project
Supports a discrete specified project performed in an investigator's area of competency. Areas of interest to ORIP include research to create new or to improve existing technologies or instruments or to establish, expand, or improve an animal model or model system.
| Funding Category | ORIP Program Description | NIH Mechanism | Find Funding |
|---|---|---|---|
| Research Grants | Academic Research Enhancement Awards (AREA) Supports small-scale, resource-related research projects conducted by faculty at institutions that award bachelor's degrees in health or the health sciences. Areas of interest to ORIP include research and development of instruments/technologies, laboratory animal sciences, or lower organisms, tissues, and cells in culture for use in biomedical research. |
R15 | Comparative Medicine |
| Resources and Centers | Animal and Biological Material Resource Centers Supports the creation, collection, and development of specialized colonies of high-quality laboratory animals and animal-related models including nonhuman primates; biological materials; genetic stocks, and animal-related information resources. These resources serve qualified investigators across almost all NIH-supported biomedical fields. |
P40 | Comparative Medicine |
| Resources and Centers | Animal Model, and Animal and Biological Materials Resource Cooperative Agreements Supports the development, preservation and distribution of mammalian and non-mammalian models critical for biomedical fields. These programs provide researchers with high-quality animal models, biomaterials, and related resources to advance studies in disease mechanisms, therapies, and drug development. Funded by NIH, they ensure accessibility to well-characterized research models that drive scientific innovation. |
U42 | Comparative Medicine |
| Research Grants | Exploratory/Developmental Research Projects Supports innovative, high-risk, exploratory/development projects for new or improved biomedical technologies or animal or animal-related models for biomedical research applications. Preliminary data are not required. Projects should challenge paradigms and encompass existing novel ideas to improve the understanding of a biomedical research problem. |
R21 | Comparative Medicine |
| Research Grants | Investigator-Initiated Research Project Supports a discrete specified project performed in an investigator's area of competency. Areas of interest to ORIP include research to create new or to improve existing technologies or instruments or to establish, expand, or improve an animal model or model system. |
R01 | Comparative Medicine |
| Resources and Centers | National Primate Research Centers Supports specialized nonhuman primate (NHP) research facilities, including core research staff, equipment, NHP breeding colonies, and related resources. These centers are accessible to qualified investigators and other peer-reviewed research project grants. |
P51 | Comparative Medicine |
| Research Career Development and Training Awards | National Research Service Award – Institutional Training Support predoctoral and postdoctoral research training biomedical, behavioral, and clinical sciences. Funded by the NIH, these grants enable institutions to develop programs that equip trainees with the kills needed for independent research careers. They award NRSAs to persons selected by them for predoctoral and postdoctoral research training in specified shortage areas. |
T32 | Comparative Medicine |
| Research Career Development and Training Awards | National Research Service Award – Professional Student Short-Term Research Training Supports institutions to provide veterinary students in health professional schools research experience for periods of two to three months during quarters or summer periods to encourage research in areas of national need. |
T35 | Comparative Medicine |
| Facilities Improvement | Research Facilities Improvement Supports expansion, remodeling, renovation, or alteration of existing research facilities or construction of new research facilities. Facilities must support basic or clinical biomedical or behavioral research or research training. |
C06 | Construction and Instruments |
| Research and Development | Research Project with Complex Structure (Cooperative Agreements) Supports cooperative agreements involving large-scale research activities with complicated structures that cannot be appropriately categorized into an available single component activity code (e.g. clinical networks, research programs, consortia). |
UM1 | Comparative Medicine |
| Research Grants | Resource-Related Grant Supports applied studies to characterize and develop new animal, cell culture, or computer/mathematics models (or to improve existing ones) that have the potential for becoming well-used systems for research projects. Applicants must demonstrate a need for the resource within the biomedical research community. See ORIP's R24 page. |
R24 | Comparative Medicine |
| Resources and Centers | Resource-Related Research Projects Supports the development, enhancement, and dissemination of critical research resources, tools, and methodologies. These projects ensure that new technologies, data, and materials are accessible to the broader scientific community. By improving research infrastructure, they enhance the quality and efficiency of biomedical studies. |
U24 | Comparative Medicine |
| Research Grants | Scientific Conferences Supports meetings, symposia, and workshops that advance biomedical and behavioral research. These grants help bring together experts to exchange knowledge, foster collaborations, and drive innovation in key scientific fields. Funding ensures the dissemination of new research, enhancing the impact of scientific discoveries. |
R13, U13 | Comparative Medicine |
| Shared Instrumentation | Shared Instrumentation Grants Supports the purchase of commercially available and technologically sophisticated instruments in the $25,000 to $2,000,000 price range. Instruments must be used on a shared basis at institutions with a high concentration of investigators supported by NIH research project grants. See ORIP's S10 page. |
S10 | Construction and Instruments |
| Small Business Award Programs | Small Business Innovation Research Awards (SBIR) Phase I (R43) supports research to establish the technical merit and feasibility of research ideas that may ultimately lead to commercial products or services that will have broad application to biomedical research. Phase I also determines the quality of performance of the small business awardee organization prior to providing further federal support. |
R43 | Small Business |
| Small Business Award Programs | Small Business Innovation Research Awards (SBIR) Phase II (R44) supports small businesses in developing and commercializing innovative biomedical technologies. Building on Phase I feasibility studies, Phase II provides funding for further research, development, and prototype validation. These awards help accelerate the transition of promising discoveries into practical healthcare solutions. |
R44 | Small Business |
| Small Business Award Programs | Small Business Technology Transfer Program (STTR) Phase I (R41) and Phase II (R42) of the STTR Program seek to increase the commercialization of technology developed through Federal funding that will ultimately benefit the public. However, the unique feature of the STTR Program is the requirement for the small business concern applicant organization to partner and formally collaborate with research universities and other nonprofit research institutions. Important differences between the SBIR and STTR program requirements are explained on the NIH SBIR and STTR Web site. |
R41, R42 | Small Business |
| Research Career Development and Training Awards | Special Emphasis Research Career Award in Pathology and Comparative Medicine Supports graduate veterinarians with gaining experience in laboratory animal sciences and comparative pathology. Funded by ORIP, this award provides mentorship and research training to advance disease modeling, translational research, and biomedical innovation. It helps recipients become established biomedical investigators in research that bridge human and animal health. |
K01 | Comparative Medicine |
| Cooperative Agreements | Centers for Precision Disease Modeling (Cooperative Agreements) Support the development and application of innovative disease models to better understand human diseases and advance precision medicine. These NIH funded centers aim to create or enhance established pipelines for preclinical scientific discovery, disease modeling, and development of clinical interventions based on innovative animal models. |
U54 | Comparative Medicine |
| Research and Development | Small Grant Program for ORIP Special Emphasis Research Career Award (SERCA) K01 Recipients Provide research support for early career scientists in developing independent research programs in biomedical and veterinary sciences, including SERCA K01 awardees to either expand their current research objectives, or to initiative a closely related pilot study, and document their growth as increasingly independent investigators. This small grant program provides mentorship and funding for research training in areas critical to ORIP's mission. It helps recipients establish themselves as leaders in their fields by fostering career development and research excellence. |
R03 | Comparative Medicine |