Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Southern Medical University, Shenzhen; Guangzhou Center for Disease Control and Prevention
Keywords: SARS-CoV-2, adenovirus vectored COVID-19 vaccine, immune response, pathology, primates
Summary of Study: Prime-boost immunization with Sad23L-nCoV-S and Ad49L-nCoV-S (both carrying the full-length of SARS-CoV-2 spike protein gene) can safely elicit strong immunity in animals.
References: PMID: 33993845 / doi: 10.1080/22221751.2021.1931466
Contact Info: Yuming Zhang: [email protected]; Tingting Li: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1931466
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Southern Medical University, Shenzhen; Guangzhou Center for Disease Control and Prevention
Keywords: SARS-CoV-2, adenovirus vectored COVID-19 vaccine, immune response, pathology, primates
Summary of Study: Prime-boost immunization with Sad23L-nCoV-S and Ad49L-nCoV-S (both carrying the full-length of SARS-CoV-2 spike protein gene) can safely elicit strong immunity in animals.
References: PMID: 33993845 / doi: 10.1080/22221751.2021.1931466
Contact Info: Yuming Zhang: [email protected]; Tingting Li: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1931466
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Public Health England, Inovio Pharmaceuticals, Oxford University
Keywords: SARS-CoV-2, synthetic DNA vaccine candidate, immune response, primates
Summary of Study: The results in a stringent preclinical SARS-CoV-2 animal model provide further support for the efficacy and safety of the synthetic DNA vaccine INO-4800 as a prophylactic countermeasure against COVID-19.
References: PMID: 34253420 / doi: 10.1016/j.vaccine.2021.06.057
Contact Info: Kate Broderick (Inovio Pharmaceuticals, Inc.; Miles Carroll (Public Health England)
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21008070?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Public Health England, Inovio Pharmaceuticals, Oxford University
Keywords: SARS-CoV-2, synthetic DNA vaccine candidate, immune response, primates
Summary of Study: The results in a stringent preclinical SARS-CoV-2 animal model provide further support for the efficacy and safety of the synthetic DNA vaccine INO-4800 as a prophylactic countermeasure against COVID-19.
References: PMID: 34253420 / doi: 10.1016/j.vaccine.2021.06.057
Contact Info: Kate Broderick (Inovio Pharmaceuticals, Inc.; Miles Carroll (Public Health England)
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21008070?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Iowa; University of Florida
Keywords: SARS-CoV-2, meta analysis, airway mucus, mucin glycoproteins, inflammation, primates
Summary of Study: Ferrets, nonhuman primates, and cats may have advantages over other models to investigate mucus in COVID-19.
References: PMID: 34794359 / doi: 10.1177/03009858211058837
Contact Info: not available
URL: https://journals.sagepub.com/doi/10.1177/03009858211058837?url_ver=Z39.88-2003&…
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Iowa; University of Florida
Keywords: SARS-CoV-2, meta analysis, airway mucus, mucin glycoproteins, inflammation, primates
Summary of Study: Ferrets, nonhuman primates, and cats may have advantages over other models to investigate mucus in COVID-19.
References: PMID: 34794359 / doi: 10.1177/03009858211058837
Contact Info: not available
URL: https://journals.sagepub.com/doi/10.1177/03009858211058837?url_ver=Z39.88-2003&…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Emory University School of Medicine
Keywords: SARS-CoV-2, several animal species, anti-viral therapeutic, vaccine development, primates
Summary of Study: Summarizing key features, strengths and weaknesses of animal models for SARS-CoV-2, focusing on their application in anti-viral therapeutic and vaccine development.
References: PMID: 33906125 / doi: 10.1016/j.coviro.2021.03.009
Contact Info: Anice Lowen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1879625721000316?via%3Dihub=
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Emory University School of Medicine
Keywords: SARS-CoV-2, several animal species, anti-viral therapeutic, vaccine development, primates
Summary of Study: Summarizing key features, strengths and weaknesses of animal models for SARS-CoV-2, focusing on their application in anti-viral therapeutic and vaccine development.
References: PMID: 33906125 / doi: 10.1016/j.coviro.2021.03.009
Contact Info: Anice Lowen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1879625721000316?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, resources, pathology, primates
Summary of Study: Because the SARS-CoV-2 pandemic has significantly increased the demand for rhesus macaques biomedical researchers will need to consider alternative NHP models for COVID-19 research and for other biomedical research studies. The authors suggest alternatives.
References: PMID: 33785923 / doi: 10.1038/s41684-021-00755-6
Contact Info: Michael Chang: chang,[email protected]
URL: https://www.nature.com/articles/s41684-021-00755-6
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, resources, pathology, primates
Summary of Study: Because the SARS-CoV-2 pandemic has significantly increased the demand for rhesus macaques biomedical researchers will need to consider alternative NHP models for COVID-19 research and for other biomedical research studies. The authors suggest alternatives.
References: PMID: 33785923 / doi: 10.1038/s41684-021-00755-6
Contact Info: Michael Chang: chang,[email protected]
URL: https://www.nature.com/articles/s41684-021-00755-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Statens Serum Institute; Robert Koch Institute; BIOQUAL; University of Southern Denmark
Keywords: SARS-CoV-2, DNA plasmid vaccine, immune response, primates
Summary of Study: The candidate plasmid DNA vaccine encoding the SARS-CoV-2 spike protein is immunogenic in different models and confers protection against lung infection in nonhuman primates. Further evaluation of this DNA vaccine candidate in clinical trials is warranted.
References: PMID: 34930909 / doi: 10.1038/s41541-021-00419-z
Contact Info: Anders Fomsgaard: [email protected]
URL: https://www.nature.com/articles/s41541-021-00419-z
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Statens Serum Institute; Robert Koch Institute; BIOQUAL; University of Southern Denmark
Keywords: SARS-CoV-2, DNA plasmid vaccine, immune response, primates
Summary of Study: The candidate plasmid DNA vaccine encoding the SARS-CoV-2 spike protein is immunogenic in different models and confers protection against lung infection in nonhuman primates. Further evaluation of this DNA vaccine candidate in clinical trials is warranted.
References: PMID: 34930909 / doi: 10.1038/s41541-021-00419-z
Contact Info: Anders Fomsgaard: [email protected]
URL: https://www.nature.com/articles/s41541-021-00419-z
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Universite Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases; University of Amsterdam; Universite de Paris, INSERM, IAME; University of Texas Medical Branch at Galveston; Galveston National Laboratory; Icahn School of Medicine at Mount Sinai; The Scripps Research Institute; Duke Human Vaccine Institute & Department of Surgery; Nexelis; The University of Maryland School of Medicine; Institut Pasteur; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, neutralizing antibody, prophylactic, pathology, mice, hamsters, primates
Summary of Study: COVA1-18, a neutralizing antibody highly potent against the B.1.1.7 isolate, has a strong antiviral activity in three preclinical models and could be a valuable candidate for further clinical evaluation.
References: PMID: 34671037 / doi: 10.1038/s41467-021-26354-0
Contact Info: Rogier Sanders: [email protected]; Marit van Gils: [email protected]; Roger Le Grand: [email protected]
URL: https://www.nature.com/articles/s41467-021-26354-0
NHP Species:
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Universite Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases; University of Amsterdam; Universite de Paris, INSERM, IAME; University of Texas Medical Branch at Galveston; Galveston National Laboratory; Icahn School of Medicine at Mount Sinai; The Scripps Research Institute; Duke Human Vaccine Institute & Department of Surgery; Nexelis; The University of Maryland School of Medicine; Institut Pasteur; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, neutralizing antibody, prophylactic, pathology, mice, hamsters, primates
Summary of Study: COVA1-18, a neutralizing antibody highly potent against the B.1.1.7 isolate, has a strong antiviral activity in three preclinical models and could be a valuable candidate for further clinical evaluation.
References: PMID: 34671037 / doi: 10.1038/s41467-021-26354-0
Contact Info: Rogier Sanders: [email protected]; Marit van Gils: [email protected]; Roger Le Grand: [email protected]
URL: https://www.nature.com/articles/s41467-021-26354-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Pasteur Institute of Iran; Amirabad Virology Laboratory; Tarbiat Modares University; University of Tehran; Islamic Azad University; Hamadan University of Medical Sciences; Darou Pakhsh Pharmaceutical; Arena Diagnostic; and others.
Keywords: SARS-CoV-2, inactivated whole-virus vaccine, safety, immune response, guinea pig, rabbit, mice, primates
Summary of Study: Rhesus macaques were immunised with the two-dose schedule of 5 or 3 ug of the B1V1-CovIran vaccine and showed highly efficient protection against 10^4 TCID50 of SARS-CoV-2 intratracheal challenge compared with the control group.
References: PMID: 34699647 / doi: 10.1002/rmv.2305
Contact Info: Reza Aalizadeh: [email protected]; Hasan Jalili: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/rmv.2305
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Pasteur Institute of Iran; Amirabad Virology Laboratory; Tarbiat Modares University; University of Tehran; Islamic Azad University; Hamadan University of Medical Sciences; Darou Pakhsh Pharmaceutical; Arena Diagnostic; and others.
Keywords: SARS-CoV-2, inactivated whole-virus vaccine, safety, immune response, guinea pig, rabbit, mice, primates
Summary of Study: Rhesus macaques were immunised with the two-dose schedule of 5 or 3 ug of the B1V1-CovIran vaccine and showed highly efficient protection against 10^4 TCID50 of SARS-CoV-2 intratracheal challenge compared with the control group.
References: PMID: 34699647 / doi: 10.1002/rmv.2305
Contact Info: Reza Aalizadeh: [email protected]; Hasan Jalili: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/rmv.2305
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Universite paris-Saclay/Inserm/Cea; Pereman School of Medicine; Novartis Gene Therapies; Boston University School of Medicine; Ragon Institute of MGH, MIT, and Harvard; and others
Keywords: SARS-CoV-2, AAV-vaccine candidates, immune response, mice, primates
Summary of Study: Studies of the AAV-based vaccine candidate AC1 support its potential to protect from COVID-19 disease and infection from a single-dose immunization; may lead to highly durable immunogenicity; and is stable at ambient temperature for storage for several weeks. The combination of these WHO-specific key attributes have not been met by any of the currently approved vaccines. Continued development of second-generation vaccine candidates such at AC1 is needed.
References: PMID: 34428428 / doi: 10.1016/j.chom.2021.08.002
Contact Info: Roger LeGrand: [email protected]; Luk Vandenberghe: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1931312821003784?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Universite paris-Saclay/Inserm/Cea; Pereman School of Medicine; Novartis Gene Therapies; Boston University School of Medicine; Ragon Institute of MGH, MIT, and Harvard; and others
Keywords: SARS-CoV-2, AAV-vaccine candidates, immune response, mice, primates
Summary of Study: Studies of the AAV-based vaccine candidate AC1 support its potential to protect from COVID-19 disease and infection from a single-dose immunization; may lead to highly durable immunogenicity; and is stable at ambient temperature for storage for several weeks. The combination of these WHO-specific key attributes have not been met by any of the currently approved vaccines. Continued development of second-generation vaccine candidates such at AC1 is needed.
References: PMID: 34428428 / doi: 10.1016/j.chom.2021.08.002
Contact Info: Roger LeGrand: [email protected]; Luk Vandenberghe: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1931312821003784?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID, Ragon Institute of MGH, MIT< and Harvard, University of Duisburg-Essen, Harvard University, Emory Vaccine Center, Yerkes National Primate Research Center, and others
Keywords: SARS-CoV-2, protein subunit vaccine, soluble prefusion-stabilized spike trimers, immune response, primates
Summary of Study: Soluble prefusion-stablized spike protein trimers (preS DTM) from SARS-CoV-2 were formulated with the adjuvant AS03 and administered twice to NHPs. Two days after challenge, vaccinated NHPs showed rapid control of viral replication in both the upper and lower airways. These data indicate that antibodies induced by the AS03-adjuvanted preS dTM vaccine were sufficient to mediate protection against SARS-CoV-2 in NHPs and that rapid anamnestic antibody responses in the lung may be a key mechanism for protection.
References: PMID: 34315825 / doi: 10.1126/scitranslmed.abi4547
Contact Info: Robert Seder: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abi4547?url_ver=Z39.88-2003&rf…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID, Ragon Institute of MGH, MIT< and Harvard, University of Duisburg-Essen, Harvard University, Emory Vaccine Center, Yerkes National Primate Research Center, and others
Keywords: SARS-CoV-2, protein subunit vaccine, soluble prefusion-stabilized spike trimers, immune response, primates
Summary of Study: Soluble prefusion-stablized spike protein trimers (preS DTM) from SARS-CoV-2 were formulated with the adjuvant AS03 and administered twice to NHPs. Two days after challenge, vaccinated NHPs showed rapid control of viral replication in both the upper and lower airways. These data indicate that antibodies induced by the AS03-adjuvanted preS dTM vaccine were sufficient to mediate protection against SARS-CoV-2 in NHPs and that rapid anamnestic antibody responses in the lung may be a key mechanism for protection.
References: PMID: 34315825 / doi: 10.1126/scitranslmed.abi4547
Contact Info: Robert Seder: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abi4547?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: The Catholic University of Korea, Korea Research Institute of Bioscience and Biotechnology, SK Science, Jeonbuk National University, and others
Keywords: SARS-CoV-2, receptor-binding domain of SARS-CoV-2, immune response, mice and primates
Summary of Study: RBD-P2 + alum immunization elicits a robust neutralizing antibody response and provides complete or near-complete elimination of live SARS-CoV-2 virus particles. Additionally, findings provide insight into the potential use of the N protein in the development of SARS-CoV-2 vaccines.
References: PMID: 34049881 / doi: 10.1126/sciadv.abg7156
Contact Info: Jae-Hwan Nam: [email protected]; Sang-Myeong Lee: [email protected]; Jung Joo Hong: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.abg7156?url_ver=Z39.88-2003&rfr_id=o…
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: The Catholic University of Korea, Korea Research Institute of Bioscience and Biotechnology, SK Science, Jeonbuk National University, and others
Keywords: SARS-CoV-2, receptor-binding domain of SARS-CoV-2, immune response, mice and primates
Summary of Study: RBD-P2 + alum immunization elicits a robust neutralizing antibody response and provides complete or near-complete elimination of live SARS-CoV-2 virus particles. Additionally, findings provide insight into the potential use of the N protein in the development of SARS-CoV-2 vaccines.
References: PMID: 34049881 / doi: 10.1126/sciadv.abg7156
Contact Info: Jae-Hwan Nam: [email protected]; Sang-Myeong Lee: [email protected]; Jung Joo Hong: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.abg7156?url_ver=Z39.88-2003&rfr_id=o…
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine; Tulane National Primate Research Center; SE LA Veterans Affairs Healthcare System, and others
Keywords: SARS-CoV-2, severe acute respiratory syndrome and diabetes, chronic pancreatic dysfunction, primates
Summary of Study: SARS-CoV-2 infects pancreatic islet, ductal, and endothelial cells in male and female NHPs and humans with COVID-19. The long-term consequences of a fibrotic/thrombotic pancreas, such as chronic pancreatic exocrine dysfunction and late-onset diabetes, should be investigated as postacute sequelae of COVID-19.
References: PMID: 34241597 / doi: 10.1172/jci.insight.151551
Contact Info: Mirza Muhammad Fahd Qadir: [email protected]; Rudolf Bohm: [email protected]
URL: https://insight.jci.org/articles/view/151551
NHP Species: african green monkeys, rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine; Tulane National Primate Research Center; SE LA Veterans Affairs Healthcare System, and others
Keywords: SARS-CoV-2, severe acute respiratory syndrome and diabetes, chronic pancreatic dysfunction, primates
Summary of Study: SARS-CoV-2 infects pancreatic islet, ductal, and endothelial cells in male and female NHPs and humans with COVID-19. The long-term consequences of a fibrotic/thrombotic pancreas, such as chronic pancreatic exocrine dysfunction and late-onset diabetes, should be investigated as postacute sequelae of COVID-19.
References: PMID: 34241597 / doi: 10.1172/jci.insight.151551
Contact Info: Mirza Muhammad Fahd Qadir: [email protected]; Rudolf Bohm: [email protected]
URL: https://insight.jci.org/articles/view/151551
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: YishengBio Co., Ltd.; Chinese Academy of Sciences; National Health Commission of the People's Republic of China
Keywords: SARS-CoV-2, S-trimer, PIKA, vaccine, virus genomic variants, primates
Summary of Study: In this study of non-human primates, PIKA adjuvanted S-trimer induced high SARS-CoV-2 neutralization titers and protected from virus replication in the lung following SARS-CoV-2 challenge.
References: PMID: 34766005 / doi: 10.1186/s43556-021-00054-z
Contact Info: Yi Zhang: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475395/
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: YishengBio Co., Ltd.; Chinese Academy of Sciences; National Health Commission of the People's Republic of China
Keywords: SARS-CoV-2, S-trimer, PIKA, vaccine, virus genomic variants, primates
Summary of Study: In this study of non-human primates, PIKA adjuvanted S-trimer induced high SARS-CoV-2 neutralization titers and protected from virus replication in the lung following SARS-CoV-2 challenge.
References: PMID: 34766005 / doi: 10.1186/s43556-021-00054-z
Contact Info: Yi Zhang: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475395/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Nagoya University; Kyushu University; Akita University Graduate School of Medicine; and others
Keywords: SARS-CoV-2, mathematical model, infection dynamics, kinetics of viral shedding, primates
Summary of Study: The authors used a simple mathematical model to quantify SARS-CoV-2 infection dynamics in rhesus macaques. When antiviral treatments are initiated early (i.e. 0.5 d after virus inoculation), viral shedding is (paradoxically) prolonged by about 6.0 days compared with no treatment.
References: PMID: 34344719 / doi: 10.26508/lsa.202101049
Contact Info: Keisuke Ejima: [email protected]; Shingo Iwami: [email protected]
URL: https://www.life-science-alliance.org/content/4/10/e202101049
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Nagoya University; Kyushu University; Akita University Graduate School of Medicine; and others
Keywords: SARS-CoV-2, mathematical model, infection dynamics, kinetics of viral shedding, primates
Summary of Study: The authors used a simple mathematical model to quantify SARS-CoV-2 infection dynamics in rhesus macaques. When antiviral treatments are initiated early (i.e. 0.5 d after virus inoculation), viral shedding is (paradoxically) prolonged by about 6.0 days compared with no treatment.
References: PMID: 34344719 / doi: 10.26508/lsa.202101049
Contact Info: Keisuke Ejima: [email protected]; Shingo Iwami: [email protected]
URL: https://www.life-science-alliance.org/content/4/10/e202101049
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Sanofi Pasteur, Yoh Services, Global Discovery Pathology, Translate Bio
Keywords: SARS-CoV-2, multiple animal species, mRNA vaccine, immune response, pathology, primates
Summary of Study: Several mRNA vaccine candidates were assessed; the lead 2P/GSAS vaccine formulation (designated MRT550) elicited potent nAbs as well as TH1-biased responses in NHPs, thus alleviating a hypothetical concern of potential vaccine-associated enhanced respiratory diseases known associated with TH2-biased responses. These data position MRT5500 as a viable vaccine candidate for entering clinical development.
References: PMID: 33875658 / doi: 10.1038/s41541-021-00324-5
Contact Info: Kirill Kalnin: [email protected]
URL: https://www.nature.com/articles/s41541-021-00324-5
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Sanofi Pasteur, Yoh Services, Global Discovery Pathology, Translate Bio
Keywords: SARS-CoV-2, multiple animal species, mRNA vaccine, immune response, pathology, primates
Summary of Study: Several mRNA vaccine candidates were assessed; the lead 2P/GSAS vaccine formulation (designated MRT550) elicited potent nAbs as well as TH1-biased responses in NHPs, thus alleviating a hypothetical concern of potential vaccine-associated enhanced respiratory diseases known associated with TH2-biased responses. These data position MRT5500 as a viable vaccine candidate for entering clinical development.
References: PMID: 33875658 / doi: 10.1038/s41541-021-00324-5
Contact Info: Kirill Kalnin: [email protected]
URL: https://www.nature.com/articles/s41541-021-00324-5
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Science, Trinomab Biotech Co.
Keywords: SARS-CoV-2, ferritin nanoparticles, receptor-binding domain of SARS-CoV-2, immune response, primates
Summary of Study: Self-assembling nanoparticle vaccines displaying the RBD of SARS-CoV-2 were prepared, and the vaccine candidate elicited robust humoral and T cell responses and protected the rhesus monkeys from infection with short-term shedding and only minor pathological damage.
References: PMID: 33951913 / doi: 10.1021/acs.bioconjchem.1c00208
Contact Info: Longding Liu: [email protected]; Qihan Li: [email protected]; Zhanlong He: [email protected]
URL: https://pubs.acs.org/doi/10.1021/acs.bioconjchem.1c00208
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Science, Trinomab Biotech Co.
Keywords: SARS-CoV-2, ferritin nanoparticles, receptor-binding domain of SARS-CoV-2, immune response, primates
Summary of Study: Self-assembling nanoparticle vaccines displaying the RBD of SARS-CoV-2 were prepared, and the vaccine candidate elicited robust humoral and T cell responses and protected the rhesus monkeys from infection with short-term shedding and only minor pathological damage.
References: PMID: 33951913 / doi: 10.1021/acs.bioconjchem.1c00208
Contact Info: Longding Liu: [email protected]; Qihan Li: [email protected]; Zhanlong He: [email protected]
URL: https://pubs.acs.org/doi/10.1021/acs.bioconjchem.1c00208
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Dalhousie University; University of Calgary
Keywords: SARS-CoV-2, anthropozoonosis, virus transmission between the animal species, primates
Summary of Study: While the risk of transmission of SARS-CoV-2 via wastewater is low, tracing of viral RNA in wastewater does provide a unique testing approach to help protect NHPs at zoos and wildlife sanctuaries.
References: PMID: 34662463 / doi: 10.1002/ajp.23340
Contact Info: Graham Dellaire: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/ajp.23340
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Dalhousie University; University of Calgary
Keywords: SARS-CoV-2, anthropozoonosis, virus transmission between the animal species, primates
Summary of Study: While the risk of transmission of SARS-CoV-2 via wastewater is low, tracing of viral RNA in wastewater does provide a unique testing approach to help protect NHPs at zoos and wildlife sanctuaries.
References: PMID: 34662463 / doi: 10.1002/ajp.23340
Contact Info: Graham Dellaire: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/ajp.23340
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Perelman School of Medicine (UPenn)
Keywords: SARS-CoV-2, clinical and pathologic consequences, ACE2 decoy protein, primates
Summary of Study: The ACE2 decoy (soluble forms of angiotensin-converting enzyme 2) gene therapy approach could be effectively deployed to vulnerable populations in the COVID-19 pandemic and potentially to broader populations at the outset of future coronavirus pandemics.
References: PMID: 34265018 / doi: 10.1371/journal.ppat.1009544
Contact Info: James Wilson: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009544
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Perelman School of Medicine (UPenn)
Keywords: SARS-CoV-2, clinical and pathologic consequences, ACE2 decoy protein, primates
Summary of Study: The ACE2 decoy (soluble forms of angiotensin-converting enzyme 2) gene therapy approach could be effectively deployed to vulnerable populations in the COVID-19 pandemic and potentially to broader populations at the outset of future coronavirus pandemics.
References: PMID: 34265018 / doi: 10.1371/journal.ppat.1009544
Contact Info: James Wilson: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009544
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; CureVac AG
Keywords: SARS-CoV-2, mRNA vaccine candidate, humoral and cellular immune responses, primates
Summary of Study: Prime boost vaccination of rhesus macaques with 4 ug of CV07050101 elicited neither a uniform nor a robust immune response. However, vaccination using 8 ug of the same vaccine was protective in an NHP challenge study.
References: PMID: 34452509 / doi: 10.3390/v13081645
Contact Info: Vincent Munster: [email protected]
URL: https://www.mdpi.com/1999-4915/13/8/1645
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; CureVac AG
Keywords: SARS-CoV-2, mRNA vaccine candidate, humoral and cellular immune responses, primates
Summary of Study: Prime boost vaccination of rhesus macaques with 4 ug of CV07050101 elicited neither a uniform nor a robust immune response. However, vaccination using 8 ug of the same vaccine was protective in an NHP challenge study.
References: PMID: 34452509 / doi: 10.3390/v13081645
Contact Info: Vincent Munster: [email protected]
URL: https://www.mdpi.com/1999-4915/13/8/1645
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Sichuan University; Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, review of the current animal models, pathology, immune response, use for the testing therapeutics and vaccines, mice, hamsters, nonhuman primates, and ferrets
Summary of Study: A variety of animal models have been developed to demonstrate the transmission, pathogenesis, and immunology induced by SARS-CoV-2 and to evaluate the immunomodulatory and antiviral drugs and vaccines against COVID-19. None of these models can completely recapitulate the changes seen in COVID-19 patients. It may be beneficial for investigators to apply appropriate options of animal models depending on the scientific goals.
References: PMID: 34909757 / doi: 10.1002/mco2.98
Contact Info: Shuaiyao Lu: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662225/pdf/MCO2-2-548.pdf
NHP Species: african green monkeys, rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Sichuan University; Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, review of the current animal models, pathology, immune response, use for the testing therapeutics and vaccines, mice, hamsters, nonhuman primates, and ferrets
Summary of Study: A variety of animal models have been developed to demonstrate the transmission, pathogenesis, and immunology induced by SARS-CoV-2 and to evaluate the immunomodulatory and antiviral drugs and vaccines against COVID-19. None of these models can completely recapitulate the changes seen in COVID-19 patients. It may be beneficial for investigators to apply appropriate options of animal models depending on the scientific goals.
References: PMID: 34909757 / doi: 10.1002/mco2.98
Contact Info: Shuaiyao Lu: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662225/pdf/MCO2-2-548.pdf
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of California-Davis; California National Primate Research Center, UC Davis; Chan Zuckerberg Biohub; Vitalant Research Institute; University of Wisconsin-Madison; Wisconsin National Primate Research Center/UW Madison; University of California-San Francisco
Keywords: SARS-CoV-2, convalescent plasma, viral shedding, treatment efficiency, primates
Summary of Study: Passive immunization with convalescent plasma (CP), even during early infection, provided no significant benefit in a nonhuman primate model of SARS-CoV-2 infection.
References: PMID: 34817208 / doi: 10.1128/Spectrum.01397-21
Contact Info: Jesse Deere: [email protected]
URL: https://journals.asm.org/doi/10.1128/Spectrum.01397-21
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of California-Davis; California National Primate Research Center, UC Davis; Chan Zuckerberg Biohub; Vitalant Research Institute; University of Wisconsin-Madison; Wisconsin National Primate Research Center/UW Madison; University of California-San Francisco
Keywords: SARS-CoV-2, convalescent plasma, viral shedding, treatment efficiency, primates
Summary of Study: Passive immunization with convalescent plasma (CP), even during early infection, provided no significant benefit in a nonhuman primate model of SARS-CoV-2 infection.
References: PMID: 34817208 / doi: 10.1128/Spectrum.01397-21
Contact Info: Jesse Deere: [email protected]
URL: https://journals.asm.org/doi/10.1128/Spectrum.01397-21
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Qassim University, Buraydah, Saudi Aribia; Imam Abdulrahman Bin Faisal University, MGM Dental College and Hospital, Baba Farid University of Health Sciences, Himachal Institute of Dental Sciences, Panineeya Mahavidyalaya
Keywords: SARS-CoV-2, immune response, animal models, meta analysis, mice, hamsters, ferrets, cats, dogs, primates
Summary of Study: This systematic review found that animal models only mimic limited signs and symptoms experienced in COVID infection as compared to infections in humans, yet are still essential to understand the pathogenesis, transmissibility or viral particles, and vaccine testing.
References: PMID: 34447038 / doi: 10.4103/jpbs.JPBS_749_20
Contact Info: Muhamood Moothedath: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375911/
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Qassim University, Buraydah, Saudi Aribia; Imam Abdulrahman Bin Faisal University, MGM Dental College and Hospital, Baba Farid University of Health Sciences, Himachal Institute of Dental Sciences, Panineeya Mahavidyalaya
Keywords: SARS-CoV-2, immune response, animal models, meta analysis, mice, hamsters, ferrets, cats, dogs, primates
Summary of Study: This systematic review found that animal models only mimic limited signs and symptoms experienced in COVID infection as compared to infections in humans, yet are still essential to understand the pathogenesis, transmissibility or viral particles, and vaccine testing.
References: PMID: 34447038 / doi: 10.4103/jpbs.JPBS_749_20
Contact Info: Muhamood Moothedath: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375911/
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Brigham and Women's Hospital and Harvard Medical School, The Affiliated Hospital of Youjiang Medical Univ. for Nationalities (China), and the University of Alabama
Keywords: SARS-CoV-2, ACE2 protein expression, lung injury, mice and primates
Summary of Study: Data from this study unequivocally support the key role of ACE2 in the sinonasal mucosa as a functional reARS-CoV-2; however, the restricted baseline expression pattern of ACE1 in the lung presents a conundrum as it raises questions about alternative viral receptors or additional mechanisms of lung injury in COVID-19 pneumonia.
References: PMID: 33626084 / doi: 10.1371/journal.pone.0247510
Contact Info: Sule Cataltepe: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0247510
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Brigham and Women's Hospital and Harvard Medical School, The Affiliated Hospital of Youjiang Medical Univ. for Nationalities (China), and the University of Alabama
Keywords: SARS-CoV-2, ACE2 protein expression, lung injury, mice and primates
Summary of Study: Data from this study unequivocally support the key role of ACE2 in the sinonasal mucosa as a functional reARS-CoV-2; however, the restricted baseline expression pattern of ACE1 in the lung presents a conundrum as it raises questions about alternative viral receptors or additional mechanisms of lung injury in COVID-19 pneumonia.
References: PMID: 33626084 / doi: 10.1371/journal.pone.0247510
Contact Info: Sule Cataltepe: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0247510
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Tsinghua University School of Medicine; Chinese Academy of Sciences; Peking Union Medical College, The University of Hong Kong, and more
Keywords: SARS-CoV-2, adenovirus vector, vaccine candidate, immune response, hamsters, mice, primates
Summary of Study: ADC68, a rare chimpanzee adenovirus serotype, was used as a vector for vaccine and induced potent and protective immune responses against SARS-CoV-2 in experimental animals, providing scientific rationale for further developing ADC68-19S as a clinical vaccine against SARS-CoV-2 infection in humans.
References: PMID: 34262569 / doi: 10.3389/fimmu.2021.697074
Contact Info: Zhiwei Chen: [email protected]; Xioxhong Peng: [email protected]; Dongming Zhou: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.697074/full
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Tsinghua University School of Medicine; Chinese Academy of Sciences; Peking Union Medical College, The University of Hong Kong, and more
Keywords: SARS-CoV-2, adenovirus vector, vaccine candidate, immune response, hamsters, mice, primates
Summary of Study: ADC68, a rare chimpanzee adenovirus serotype, was used as a vector for vaccine and induced potent and protective immune responses against SARS-CoV-2 in experimental animals, providing scientific rationale for further developing ADC68-19S as a clinical vaccine against SARS-CoV-2 infection in humans.
References: PMID: 34262569 / doi: 10.3389/fimmu.2021.697074
Contact Info: Zhiwei Chen: [email protected]; Xioxhong Peng: [email protected]; Dongming Zhou: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.697074/full
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chulalongkorn University, Mahidol University, Baiya Phytopharm Co., National Center for Genetic Engineering and Biotechnology
Keywords: SARS-CoV-2, plant-produced receptor-binding domain, immune response, primates
Summary of Study: The plant-based protein RBD-Fc was shown to be immunogenic and significantly boosted a humoral and cell-mediated immune response in both mice and cynomolgus macaques. This protein has the potential for use as a vaccine candidate against SARS-CoV-2.
References: PMID: 34054909 / doi: 10.3389/fpls.2021.682953
Contact Info: Waranyoo Phoolcharoen: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158422/
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chulalongkorn University, Mahidol University, Baiya Phytopharm Co., National Center for Genetic Engineering and Biotechnology
Keywords: SARS-CoV-2, plant-produced receptor-binding domain, immune response, primates
Summary of Study: The plant-based protein RBD-Fc was shown to be immunogenic and significantly boosted a humoral and cell-mediated immune response in both mice and cynomolgus macaques. This protein has the potential for use as a vaccine candidate against SARS-CoV-2.
References: PMID: 34054909 / doi: 10.3389/fpls.2021.682953
Contact Info: Waranyoo Phoolcharoen: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158422/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: DSO National Laboratories, Singapore; University of Texas Medical Branch; Hummingbird Bioscience; and others
Keywords: SARS-CoV-2, neutralizing antibodies, immune response, hamsters and primates
Summary of Study: SC31, a potent SARS-CoV-2 neutralizing antibody isolated from a convalescent patient, demonstrated therapeutic efficacy in three different models.
References: PMID: 34161386 / doi: 10.1371/journal.pone.0253487
Contact Info: Brendon John Hanson: [email protected]; Trevor Brasel: [email protected]; Piers J. Ingram: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0253487
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: DSO National Laboratories, Singapore; University of Texas Medical Branch; Hummingbird Bioscience; and others
Keywords: SARS-CoV-2, neutralizing antibodies, immune response, hamsters and primates
Summary of Study: SC31, a potent SARS-CoV-2 neutralizing antibody isolated from a convalescent patient, demonstrated therapeutic efficacy in three different models.
References: PMID: 34161386 / doi: 10.1371/journal.pone.0253487
Contact Info: Brendon John Hanson: [email protected]; Trevor Brasel: [email protected]; Piers J. Ingram: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0253487
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Hebei Agricultural University; Military Veterinary Research Institute
Keywords: SARS-CoV-2, aerosol particles, virus transduction, primates
Summary of Study: Most SARS-CoV-2 aerosol particles exhaled by the cynomolgus monkeys in this study were smaller (<4.7 um), suggesting that aerosols might be a route for SARS-CoV-2 transmission.
References: PMID: 34152969 / doi: 10.3201/eid2707.203948
Contact Info: Yuwei Gao: [email protected]
URL: https://wwwnc.cdc.gov/eid/article/27/7/20-3948_article
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Hebei Agricultural University; Military Veterinary Research Institute
Keywords: SARS-CoV-2, aerosol particles, virus transduction, primates
Summary of Study: Most SARS-CoV-2 aerosol particles exhaled by the cynomolgus monkeys in this study were smaller (<4.7 um), suggesting that aerosols might be a route for SARS-CoV-2 transmission.
References: PMID: 34152969 / doi: 10.3201/eid2707.203948
Contact Info: Yuwei Gao: [email protected]
URL: https://wwwnc.cdc.gov/eid/article/27/7/20-3948_article
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Nankai University, Chinese Academy of Sciences, and others
Keywords: SARS-CoV-2, monoclonal antibodies, structure analysis, immune response, primates
Summary of Study: The engineered antibody P4A1 (originally identified from COVID-19 convalescent patients) exhibits an optimized pharmacokinetic and safety profile, and results in complete viral clearance in a rhesus monkey model of COVID-19 following a single injection.
References: PMID: 33976198 / doi: 10.1038/s41467-021-22926-2
Contact Info: Yu Guo: [email protected]; Hongkai Zhang: [email protected]
URL: https://www.nature.com/articles/s41467-021-22926-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Nankai University, Chinese Academy of Sciences, and others
Keywords: SARS-CoV-2, monoclonal antibodies, structure analysis, immune response, primates
Summary of Study: The engineered antibody P4A1 (originally identified from COVID-19 convalescent patients) exhibits an optimized pharmacokinetic and safety profile, and results in complete viral clearance in a rhesus monkey model of COVID-19 following a single injection.
References: PMID: 33976198 / doi: 10.1038/s41467-021-22926-2
Contact Info: Yu Guo: [email protected]; Hongkai Zhang: [email protected]
URL: https://www.nature.com/articles/s41467-021-22926-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, neurotropism, central neural system, virus transduction, primates
Summary of Study: The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys.
References: PMID: 33895780 / doi: 10.1038/s41392-021-00591-7
Contact Info: Xiaozhong Peng: [email protected]; Shuaiyao Lu: [email protected]; Hongqi Liu: [email protected]
URL: https://www.nature.com/articles/s41392-021-00591-7
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, neurotropism, central neural system, virus transduction, primates
Summary of Study: The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys.
References: PMID: 33895780 / doi: 10.1038/s41392-021-00591-7
Contact Info: Xiaozhong Peng: [email protected]; Shuaiyao Lu: [email protected]; Hongqi Liu: [email protected]
URL: https://www.nature.com/articles/s41392-021-00591-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP, NIH
Keywords: SARS-CoV-2, the use of primates for COVID research, animal resources
Summary of Study: The SARS-CoV-2/COVID-19 pandemic has significantly increased the demand for specific-pathogen-free (SFP) NHPs for development of vaccines and therapeutics. Non-SPF animals, which are available in greater numbers and include well-characterized primate species, should be considered in lieu of limited SPF animals for appropriate research studies.
References: doi: 10.1038/s41684-021-00810-2
Contact Info: Miguel Contreras: miguel.contreras
URL: https://www.nature.com/articles/s41684-021-00810-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP, NIH
Keywords: SARS-CoV-2, the use of primates for COVID research, animal resources
Summary of Study: The SARS-CoV-2/COVID-19 pandemic has significantly increased the demand for specific-pathogen-free (SFP) NHPs for development of vaccines and therapeutics. Non-SPF animals, which are available in greater numbers and include well-characterized primate species, should be considered in lieu of limited SPF animals for appropriate research studies.
References: doi: 10.1038/s41684-021-00810-2
Contact Info: Miguel Contreras: miguel.contreras
URL: https://www.nature.com/articles/s41684-021-00810-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Florida State University; University of Texas Medical Branch; Perelman School of Medicine; Duke University Medical Center; Johns Hopkins School of Medicine
Keywords: SARS-CoV-2, respiratory viral challenge, immune response, pathology, primates
Summary of Study: Data demonstrate that SARS-CoV-2 infection of pigtail macaques recapitulates important features of COVID-19 and reveals new immune and viral dynamics and thus may serve as a useful animal model for studying pathogenesis and testing vaccines and therapeutics.
References: PMID: 34929014 / doi: 10.1371/journal.ppat.1010162
Contact Info: Nicholas Maness: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010162
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Florida State University; University of Texas Medical Branch; Perelman School of Medicine; Duke University Medical Center; Johns Hopkins School of Medicine
Keywords: SARS-CoV-2, respiratory viral challenge, immune response, pathology, primates
Summary of Study: Data demonstrate that SARS-CoV-2 infection of pigtail macaques recapitulates important features of COVID-19 and reveals new immune and viral dynamics and thus may serve as a useful animal model for studying pathogenesis and testing vaccines and therapeutics.
References: PMID: 34929014 / doi: 10.1371/journal.ppat.1010162
Contact Info: Nicholas Maness: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010162
Coronavirus Investigated: SARS-CoV-2
NHP Species: tamarins, marmosets, howler monkeys, titi monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Faculdade de Medicina de Sao Jose do Rio Preto, Brazil; Fundacao de Medicina Tropical Doutor Heitor Vieria Dourado, Brazil; Universidade do Estado do Amazonas, Brazil; Universidade Federal do Amazonas, Brazil; Universidade de Sao Paulo, Brazil; Hospital Israelita Albert Einstein; Instituto Butanta; Departamento de Vigilancia Epidemiologica de Sao Jose do Rio Preto; New Mexico State University; The University of Texas Medical Branch, Galveston; Instituto Leonidas e Maria Deane, Brazil
Keywords: SARS-CoV-2, wild animals, molecular and serological tests, primates
Summary of Study: Although no evidence of SARS-CoV-2 infection was detected, continued surveillance of NHPs in this region is warranted and may identify geographic areas or particular NHP species prone to spillover.
References: PMID: 34696363 / doi: 10.3390/v13101933
Contact Info: Marcus Vinicius Guimaraes de Lacerda: [email protected]; Mauricio Lacerda Nogueira: [email protected]
URL: https://www.mdpi.com/1999-4915/13/10/1933
NHP Species: tamarins, marmosets, howler monkeys, titi monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Faculdade de Medicina de Sao Jose do Rio Preto, Brazil; Fundacao de Medicina Tropical Doutor Heitor Vieria Dourado, Brazil; Universidade do Estado do Amazonas, Brazil; Universidade Federal do Amazonas, Brazil; Universidade de Sao Paulo, Brazil; Hospital Israelita Albert Einstein; Instituto Butanta; Departamento de Vigilancia Epidemiologica de Sao Jose do Rio Preto; New Mexico State University; The University of Texas Medical Branch, Galveston; Instituto Leonidas e Maria Deane, Brazil
Keywords: SARS-CoV-2, wild animals, molecular and serological tests, primates
Summary of Study: Although no evidence of SARS-CoV-2 infection was detected, continued surveillance of NHPs in this region is warranted and may identify geographic areas or particular NHP species prone to spillover.
References: PMID: 34696363 / doi: 10.3390/v13101933
Contact Info: Marcus Vinicius Guimaraes de Lacerda: [email protected]; Mauricio Lacerda Nogueira: [email protected]
URL: https://www.mdpi.com/1999-4915/13/10/1933
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center, Tulane University School of Medicine, Tulane University, Brigham and Women's Hospital/Harvard Medical School, LSU Health Science Center, Julius-Maximilians-Universitat Wurzburg, and more
Keywords: SARS-CoV-2, pulmonary vascular endotheliosis, perivascular inflammation, rodents and primates
Summary of Study: SARS-CoV-2 causes endotheliitis via both infection and infection-mediated immune activation, which may contribute to the pathogenesis of severe COVID-19 disease.
References: PMID: 34335981 / doi: 10.7150/thno.61810
Contact Info: Jay Kolls: [email protected]; Fengming Liu: [email protected]; Jay Rappaport: [email protected]
URL: https://www.thno.org/v11p8076.htm
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center, Tulane University School of Medicine, Tulane University, Brigham and Women's Hospital/Harvard Medical School, LSU Health Science Center, Julius-Maximilians-Universitat Wurzburg, and more
Keywords: SARS-CoV-2, pulmonary vascular endotheliosis, perivascular inflammation, rodents and primates
Summary of Study: SARS-CoV-2 causes endotheliitis via both infection and infection-mediated immune activation, which may contribute to the pathogenesis of severe COVID-19 disease.
References: PMID: 34335981 / doi: 10.7150/thno.61810
Contact Info: Jay Kolls: [email protected]; Fengming Liu: [email protected]; Jay Rappaport: [email protected]
URL: https://www.thno.org/v11p8076.htm
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences; Shenzhen Kangtai Biotechnology Co., Ltd.; Academy of Military Medical Sciences; Zhenzhou University; National Institutes for Food and Drug Control; Henan Normal University
Keywords: SARS-CoV-2, chimeric spike protein, humoral immune response, pathology, mice, primates
Summary of Study: The strategy of chimerica expression SARS-CoV-2 S RBD in SARS-CoV represents a new design for other vaccine platforms.
References: PMID: 34759261 / doi: 10.1038/s41392-021-00797-9
Contact Info: Shuguang Duo: [email protected]
URL: https://www.nature.com/articles/s41392-021-00797-9
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences; Shenzhen Kangtai Biotechnology Co., Ltd.; Academy of Military Medical Sciences; Zhenzhou University; National Institutes for Food and Drug Control; Henan Normal University
Keywords: SARS-CoV-2, chimeric spike protein, humoral immune response, pathology, mice, primates
Summary of Study: The strategy of chimerica expression SARS-CoV-2 S RBD in SARS-CoV represents a new design for other vaccine platforms.
References: PMID: 34759261 / doi: 10.1038/s41392-021-00797-9
Contact Info: Shuguang Duo: [email protected]
URL: https://www.nature.com/articles/s41392-021-00797-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Celltech Pharmed Co.; Iran University of Medical Sciences; University of Iran; Tarbiat Modares University; Royan Institute for Stem Cell Biology and Technology; and others
Keywords: SARS-CoV-2, mRNA-vaccine, lipid nanoparticle, spike protein, immune response, primates
Summary of Study: A novel mRNA-LNP vaccine against SARS-CoV-2 was developed and preclinically evaluated, revealing that it was efficient enough to induce high level production of neutralizing antibodies against SARS-CoV-2 in mice and rhesus macaque monkeys.
References: PMID: 34579244 / doi: 10.3390/vaccines9091007
Contact Info: Alireza Sohi: [email protected]; Jafar Kiani: [email protected]; Ehsan Arefian: [email protected]; Arezou Khosrojerdi: [email protected]; Mohammad Zim: [email protected]
URL: https://www.mdpi.com/2076-393X/9/9/1007
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Celltech Pharmed Co.; Iran University of Medical Sciences; University of Iran; Tarbiat Modares University; Royan Institute for Stem Cell Biology and Technology; and others
Keywords: SARS-CoV-2, mRNA-vaccine, lipid nanoparticle, spike protein, immune response, primates
Summary of Study: A novel mRNA-LNP vaccine against SARS-CoV-2 was developed and preclinically evaluated, revealing that it was efficient enough to induce high level production of neutralizing antibodies against SARS-CoV-2 in mice and rhesus macaque monkeys.
References: PMID: 34579244 / doi: 10.3390/vaccines9091007
Contact Info: Alireza Sohi: [email protected]; Jafar Kiani: [email protected]; Ehsan Arefian: [email protected]; Arezou Khosrojerdi: [email protected]; Mohammad Zim: [email protected]
URL: https://www.mdpi.com/2076-393X/9/9/1007
Coronavirus Investigated: SARS-CoV-2
NHP Species: lemurs, lorises
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Calgary; Institut de Biologia Evolutiva, Universitat Pompeu Fabra; North Carolina Central University, Duke University and others
Keywords: SARS-CoV-2, ACE2 gene and protein sequences, several species, primates
Summary of Study: Study suggests that lemurs of the families Indriidae, Daubentonlidae, and Lemuridae are likely to be particularly vulnerable to SARS-CoV-2 infection.
References: PMID: 33792947 / doi: 10.1002/ajp.23255
Contact Info: James Higham: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/ajp.23255
NHP Species: lemurs, lorises
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Calgary; Institut de Biologia Evolutiva, Universitat Pompeu Fabra; North Carolina Central University, Duke University and others
Keywords: SARS-CoV-2, ACE2 gene and protein sequences, several species, primates
Summary of Study: Study suggests that lemurs of the families Indriidae, Daubentonlidae, and Lemuridae are likely to be particularly vulnerable to SARS-CoV-2 infection.
References: PMID: 33792947 / doi: 10.1002/ajp.23255
Contact Info: James Higham: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/ajp.23255
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences
Keywords: SARS-CoV-2, virus entry mediated by ACE2, several species
Summary of Study: A natural isoform of the rhesus macaque ACE2 protein with the Y217N mutation was resistant to SARS-CoV-2 infection, highlighting the possible impact of this ACE2 mutation on SARS-CoV-2 studies in rhesus macaques. The authors also demonstrated that the Y217 residue of ACE2 is a critical determinant for the ability of ACE2 to mediate SARS-CoV-2 entry. The results of this study clarify that SARS-CoV-2 can use the ACE2 receptors of multiple animal species and show that tracking the natural reservoirs and intermediate hosts of SARS-CoV-2 is complex.
References: PMID: 33610551 / doi: 10.1016/j.jbc.2021.100435
Contact Info: Yan-Dong Tang: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0021925821002088?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences
Keywords: SARS-CoV-2, virus entry mediated by ACE2, several species
Summary of Study: A natural isoform of the rhesus macaque ACE2 protein with the Y217N mutation was resistant to SARS-CoV-2 infection, highlighting the possible impact of this ACE2 mutation on SARS-CoV-2 studies in rhesus macaques. The authors also demonstrated that the Y217 residue of ACE2 is a critical determinant for the ability of ACE2 to mediate SARS-CoV-2 entry. The results of this study clarify that SARS-CoV-2 can use the ACE2 receptors of multiple animal species and show that tracking the natural reservoirs and intermediate hosts of SARS-CoV-2 is complex.
References: PMID: 33610551 / doi: 10.1016/j.jbc.2021.100435
Contact Info: Yan-Dong Tang: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0021925821002088?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Russian Academy of Sciences, Sechenov First Moscow State Medical University, Lomonosov Moscow State University
Keywords: SARS-CoV-2, serology, neutralizing antibodies, immunogenicity, inactivated vaccine, primates
Summary of Study: A B-propiolactone-inactivated whole virion vaccine CoviVac was developed and assessed. The vaccine produced stable and robust humoral immune response in mice, Syrian hamsters and common marmosets.
References: PMID: 34427172 / doi: 10.1080/22221751.2021.1971569
Contact Info: Liubov Kozlovskaya: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1971569
NHP Species: marmosets
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Russian Academy of Sciences, Sechenov First Moscow State Medical University, Lomonosov Moscow State University
Keywords: SARS-CoV-2, serology, neutralizing antibodies, immunogenicity, inactivated vaccine, primates
Summary of Study: A B-propiolactone-inactivated whole virion vaccine CoviVac was developed and assessed. The vaccine produced stable and robust humoral immune response in mice, Syrian hamsters and common marmosets.
References: PMID: 34427172 / doi: 10.1080/22221751.2021.1971569
Contact Info: Liubov Kozlovskaya: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1971569
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, hamadryas baboons, marmosets
Year Published: 2021
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center, Texas Biomedical Research Institute, Regeneron, and others
Keywords: SARS-CoV-2, severe acute respiratory syndrome, young and old animals, primates
Summary of Study: Acute respiratory distress in macaques and baboons recapitulates the progression of COVID-19 in humans, making them suitable as models to test vaccines and therapies.
References: PMID: 33340034 / doi: 10.1038/s41564-020-00841-4
Contact Info: Deepak Kaushal: [email protected], Luis Giavedoni: [email protected]
URL: https://www.nature.com/articles/s41564-020-00841-4#Sec9
NHP Species: rhesus macaques, hamadryas baboons, marmosets
Year Published: 2021
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center, Texas Biomedical Research Institute, Regeneron, and others
Keywords: SARS-CoV-2, severe acute respiratory syndrome, young and old animals, primates
Summary of Study: Acute respiratory distress in macaques and baboons recapitulates the progression of COVID-19 in humans, making them suitable as models to test vaccines and therapies.
References: PMID: 33340034 / doi: 10.1038/s41564-020-00841-4
Contact Info: Deepak Kaushal: [email protected], Luis Giavedoni: [email protected]
URL: https://www.nature.com/articles/s41564-020-00841-4#Sec9
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Duke University School of Medicine, UNC Chapel Hill, NIAID, Harvard Medical School, and others
Keywords: SARS-CoV-2, neutralizing antibodies, immune response, primates
Summary of Study: In vitro infection-enhancing RBC and NTD ABs controlled virus in vito and was rarely associated with enhanced lung pathology.
References: PMID: 34242577 / doi: 10.1016/j.cell.2021.06.021
Contact Info: Barton Haynes (Duke University School of Medicine); Kevin Saunders (Duke University School of Medicine)
URL: https://www.sciencedirect.com/science/article/pii/S009286742100756X?via%3Dihub=
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Duke University School of Medicine, UNC Chapel Hill, NIAID, Harvard Medical School, and others
Keywords: SARS-CoV-2, neutralizing antibodies, immune response, primates
Summary of Study: In vitro infection-enhancing RBC and NTD ABs controlled virus in vito and was rarely associated with enhanced lung pathology.
References: PMID: 34242577 / doi: 10.1016/j.cell.2021.06.021
Contact Info: Barton Haynes (Duke University School of Medicine); Kevin Saunders (Duke University School of Medicine)
URL: https://www.sciencedirect.com/science/article/pii/S009286742100756X?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Sabzevar University of Medical Sciences, University of Edinburgh, Nagasaki University
Keywords: SARS-CoV-2, infective dose, several animal species, pathogenesis, primates
Summary of Study: This review focused on comparative infective dose studies for SARS-CoV-2, SARS-CoV-1, and MERS. The review suggests that the infective dose in humans is small, perhaps about 100 particles. Further work is required to understand the relationship between routes of transmission, infective dose, co-infection and outcomes.
References: PMID: 33849679 / doi: 10.1017/S0950268821000790
Contact Info: Sedighe Karimzadeh: [email protected]; Raj Bhopal: [email protected]
URL: https://www.cambridge.org/core/journals/epidemiology-and-infection/article/revi…
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Sabzevar University of Medical Sciences, University of Edinburgh, Nagasaki University
Keywords: SARS-CoV-2, infective dose, several animal species, pathogenesis, primates
Summary of Study: This review focused on comparative infective dose studies for SARS-CoV-2, SARS-CoV-1, and MERS. The review suggests that the infective dose in humans is small, perhaps about 100 particles. Further work is required to understand the relationship between routes of transmission, infective dose, co-infection and outcomes.
References: PMID: 33849679 / doi: 10.1017/S0950268821000790
Contact Info: Sedighe Karimzadeh: [email protected]; Raj Bhopal: [email protected]
URL: https://www.cambridge.org/core/journals/epidemiology-and-infection/article/revi…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Fudan University, Second Military Medical University, Peking University
Keywords: SARS-CoV-2, cell-based vaccine, neutralizing antibodies, immune response, pathology, mice, primates
Summary of Study: The data present strong evidence supporting the promise of K562-S (a novel cell-based vaccine candidate that uses human cell K562 as a cellular carrier to display Spike (S) protein on the membrane) as a new effective vaccine for the prevention of COVID-19.
References: PMID: 34304724 / doi: 10.1080/22221751.2021.1957400
Contact Info: Jianqing Xu: [email protected]; Xiaoyan Zhang: [email protected]; Chen Zhao: [email protected]; Ping Zhao: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1957400
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Fudan University, Second Military Medical University, Peking University
Keywords: SARS-CoV-2, cell-based vaccine, neutralizing antibodies, immune response, pathology, mice, primates
Summary of Study: The data present strong evidence supporting the promise of K562-S (a novel cell-based vaccine candidate that uses human cell K562 as a cellular carrier to display Spike (S) protein on the membrane) as a new effective vaccine for the prevention of COVID-19.
References: PMID: 34304724 / doi: 10.1080/22221751.2021.1957400
Contact Info: Jianqing Xu: [email protected]; Xiaoyan Zhang: [email protected]; Chen Zhao: [email protected]; Ping Zhao: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1957400
Coronavirus Investigated: SARS-CoV-2
NHP Species: olive baboons
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Novavax, University of Maryland, University of Oklahoma, and others
Keywords: SARS-CoV-2, subunit vaccine (NVX-CoV2373), mice and primates
Summary of Study: Administering a subunit vaccine (NVX-CoV2373) constructed from the full-length S-protein, with Matrix-M adjuvant in a nonhuman primate model induces B- and T-cell responses, hACE2-receptor-blocking antibodies, and SARS-CoV-2 neutralizing antibodies. These results support the clinical development of the NVX-C0V2373 vaccine for prevention of COVID-19.
References: PMID: 33446655 / doi: 10.1038/s41467-020-20653-8
Contact Info: Gale Smith: [email protected]
URL: https://www.nature.com/articles/s41467-020-20653-8
NHP Species: olive baboons
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Novavax, University of Maryland, University of Oklahoma, and others
Keywords: SARS-CoV-2, subunit vaccine (NVX-CoV2373), mice and primates
Summary of Study: Administering a subunit vaccine (NVX-CoV2373) constructed from the full-length S-protein, with Matrix-M adjuvant in a nonhuman primate model induces B- and T-cell responses, hACE2-receptor-blocking antibodies, and SARS-CoV-2 neutralizing antibodies. These results support the clinical development of the NVX-C0V2373 vaccine for prevention of COVID-19.
References: PMID: 33446655 / doi: 10.1038/s41467-020-20653-8
Contact Info: Gale Smith: [email protected]
URL: https://www.nature.com/articles/s41467-020-20653-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Indian Veterinary Research Institute and others
Keywords: SARS-CoV-2, domestic and wild animal species, public health
Summary of Study: This review analyzes the current evidence of SARS-CoV-2 natural infection in domestic and wild animal species and their possible implications on public health.
References: PMID: 33892621 / doi: 10.1080/01652176/2021.1921311
Contact Info: Khan Sharun: [email protected]; Kuldeep Dhama: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128218/pdf/TVEQ_41_1921311.pdf
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Indian Veterinary Research Institute and others
Keywords: SARS-CoV-2, domestic and wild animal species, public health
Summary of Study: This review analyzes the current evidence of SARS-CoV-2 natural infection in domestic and wild animal species and their possible implications on public health.
References: PMID: 33892621 / doi: 10.1080/01652176/2021.1921311
Contact Info: Khan Sharun: [email protected]; Kuldeep Dhama: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128218/pdf/TVEQ_41_1921311.pdf
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Texas Medical Branch
Keywords: SARS-CoV-2, convalescent sera, primates
Summary of Study: Convalescent plasma therapy in humans may be an effective strategy provided that donor sera contain high anti-SARS-CoV-2 neutralizing titers given in early states of the disease.
References: PMID: 33662255 / doi: 10.1016/j.celrep.2021.108837
Contact Info: Thomas W. Geisbert:
URL: https://www.sciencedirect.com/science/article/pii/S2211124721001510?via%3Dihub=
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Texas Medical Branch
Keywords: SARS-CoV-2, convalescent sera, primates
Summary of Study: Convalescent plasma therapy in humans may be an effective strategy provided that donor sera contain high anti-SARS-CoV-2 neutralizing titers given in early states of the disease.
References: PMID: 33662255 / doi: 10.1016/j.celrep.2021.108837
Contact Info: Thomas W. Geisbert:
URL: https://www.sciencedirect.com/science/article/pii/S2211124721001510?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Washington Univ SOM, NIAID
Keywords: SARS-CoV-2, adenovirus-vectored vaccine, immunogenicity and protective efficacy, primates
Summary of Study: A single intranasal dose of ChAd-SARS-CoV-2-S induces neutralizing antibodies and T cell responses and limits or prevents infection in the upper and lower respiratory tracts after SARS-CoV-2 challenge in rhesus macaques.
References: PMID: 33754147 / doi: 10.1016/j.xcrm.2021.100230
Contact Info: Heinz Feldmann: [email protected]; Michael Diamond: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S266637912100046X?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Washington Univ SOM, NIAID
Keywords: SARS-CoV-2, adenovirus-vectored vaccine, immunogenicity and protective efficacy, primates
Summary of Study: A single intranasal dose of ChAd-SARS-CoV-2-S induces neutralizing antibodies and T cell responses and limits or prevents infection in the upper and lower respiratory tracts after SARS-CoV-2 challenge in rhesus macaques.
References: PMID: 33754147 / doi: 10.1016/j.xcrm.2021.100230
Contact Info: Heinz Feldmann: [email protected]; Michael Diamond: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S266637912100046X?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; CureVac AG
Keywords: SARS-CoV-2, mRNA-vaccine, spike protein, humoral and cellular immune responses, primates
Summary of Study: Prime-boost vaccination with 4 ug of vaccine candidate CV07050101 resulted in limited immune responses in four out of six non-human primates.
References: PMID: 34452509 / doi: 10.3390/v13081645
Contact Info: Vincent Munster: [email protected]
URL: https://www.mdpi.com/1999-4915/13/8/1645
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; CureVac AG
Keywords: SARS-CoV-2, mRNA-vaccine, spike protein, humoral and cellular immune responses, primates
Summary of Study: Prime-boost vaccination with 4 ug of vaccine candidate CV07050101 resulted in limited immune responses in four out of six non-human primates.
References: PMID: 34452509 / doi: 10.3390/v13081645
Contact Info: Vincent Munster: [email protected]
URL: https://www.mdpi.com/1999-4915/13/8/1645
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIH
Keywords: SARS-CoV-2, single-cell RNA sequencing, lung cells, primates
Summary of Study: Monocyte-derived macrophages recruited to the lungs, rather than tissue-resident alveolar macrophages, were most likely to be responsible for phagocytosis of infected cells and cellular debris early in infection, with their roles switching during clearance of infection.
References: PMID: 33431511 / doi: 10.1126/scitranslmed.abe8146
Contact Info: Emmie DeWit: [email protected]
URL: https://stm.sciencemag.org/content/13/578/eabe8146.short
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIH
Keywords: SARS-CoV-2, single-cell RNA sequencing, lung cells, primates
Summary of Study: Monocyte-derived macrophages recruited to the lungs, rather than tissue-resident alveolar macrophages, were most likely to be responsible for phagocytosis of infected cells and cellular debris early in infection, with their roles switching during clearance of infection.
References: PMID: 33431511 / doi: 10.1126/scitranslmed.abe8146
Contact Info: Emmie DeWit: [email protected]
URL: https://stm.sciencemag.org/content/13/578/eabe8146.short
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: NCR Biotech Science Cluster; Indian Institute of Technology Kharagpur; Krishi Vigyan Kendra; Inter University Centre for Biomedical Research and Super Speciality Hospital
Keywords: SARS-CoV-2, zoonotic diseases, one health approach, multiple species, primates
Summary of Study: This review examines the different natural and experimentally induced cases of human to animal SARS-CoV-2 infection (reverse zoonosis).
References: PMID: 34903944 / doi: 10.14202/vetworld.2021.2817-2826
Contact Info: R. Kumar Pramod: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654767/pdf/Vetworld-14-2817.pdf
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: NCR Biotech Science Cluster; Indian Institute of Technology Kharagpur; Krishi Vigyan Kendra; Inter University Centre for Biomedical Research and Super Speciality Hospital
Keywords: SARS-CoV-2, zoonotic diseases, one health approach, multiple species, primates
Summary of Study: This review examines the different natural and experimentally induced cases of human to animal SARS-CoV-2 infection (reverse zoonosis).
References: PMID: 34903944 / doi: 10.14202/vetworld.2021.2817-2826
Contact Info: R. Kumar Pramod: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654767/pdf/Vetworld-14-2817.pdf
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; CureVac AG; Tufts University Cummings School of Veterinary Medicine; University of North Carolina at Chapel Hill; Beth Israel Deaconess Medical Center; Bioqual; Washington University School of Medicine; Ragon Institute of MGH, MIT and Harvard
Keywords: SARS-CoV-2, mRNA vaccine, immunogenicity, protective efficacy, primates
Summary of Study: Optimization of non-coding regions can greatly improve the immunogenicity and protective efficacy of a non-modified mRNA SARS-CoV-2 vaccine in nonhuman primates.
References: PMID: 34794169 / doi: 10.1038/s41586-021-04231-6
Contact Info: Dan Barouch: [email protected]; Susanne Rauch: [email protected]
URL: https://www.nature.com/articles/s41586-021-04231-6
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; CureVac AG; Tufts University Cummings School of Veterinary Medicine; University of North Carolina at Chapel Hill; Beth Israel Deaconess Medical Center; Bioqual; Washington University School of Medicine; Ragon Institute of MGH, MIT and Harvard
Keywords: SARS-CoV-2, mRNA vaccine, immunogenicity, protective efficacy, primates
Summary of Study: Optimization of non-coding regions can greatly improve the immunogenicity and protective efficacy of a non-modified mRNA SARS-CoV-2 vaccine in nonhuman primates.
References: PMID: 34794169 / doi: 10.1038/s41586-021-04231-6
Contact Info: Dan Barouch: [email protected]; Susanne Rauch: [email protected]
URL: https://www.nature.com/articles/s41586-021-04231-6