Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Research Institute for Biological Safety Problems, Kazakhstan
Keywords: SARS-CoV-2, inactivated vaccine, safety, immune response, several animal species, primates
Summary of Study: The first COVID-19 inactivated vaccine developed in Kazakhstan did not result in any adverse effect or change in condition of the animals' health, has high immunogenic potential, and is safe to move to clinical research.
References: PMID: 35960911 / doi: 10.1080/21645515.2022.2087412
Contact Info: Zhandos Abay: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/21645515.2022.2087412
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Research Institute for Biological Safety Problems, Kazakhstan
Keywords: SARS-CoV-2, inactivated vaccine, safety, immune response, several animal species, primates
Summary of Study: The first COVID-19 inactivated vaccine developed in Kazakhstan did not result in any adverse effect or change in condition of the animals' health, has high immunogenic potential, and is safe to move to clinical research.
References: PMID: 35960911 / doi: 10.1080/21645515.2022.2087412
Contact Info: Zhandos Abay: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/21645515.2022.2087412
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; AstraZeneca; Vanderbilt University Medical Center; Ragon Institute of MGH, MIT, and Harvard, Cambridge
Keywords: SARS-CoV-2, vaccine, bivalent monoclonal antibody, immune response, primates
Summary of Study: Using human monoclonal antibodies that target the spike glycoprotein can be administered along with viral vector-based SARS-CoV-2 vaccines without losing any effectiveness of either product.
References: PMID: 35857623 / doi: 10.1126/scitranslmed.abo6160
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abo6160?rfr_dat=cr_pub%20…
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; AstraZeneca; Vanderbilt University Medical Center; Ragon Institute of MGH, MIT, and Harvard, Cambridge
Keywords: SARS-CoV-2, vaccine, bivalent monoclonal antibody, immune response, primates
Summary of Study: Using human monoclonal antibodies that target the spike glycoprotein can be administered along with viral vector-based SARS-CoV-2 vaccines without losing any effectiveness of either product.
References: PMID: 35857623 / doi: 10.1126/scitranslmed.abo6160
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abo6160?rfr_dat=cr_pub%20…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: hhc Data Creation Center, Tsukuba Research Laboratories, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan; Drug Discovery Platform, KAN Research Institute, Inc., 6-8-2 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan; Medicine Development Center, Tsukuba Research Laboratories, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan; Department of Immunology and Parasitology, Graduate School of Medicine, Tokushima University, Tokushima 770-8503, Japan.
Keywords: SARS-CoV-2, lipid nanoparticles, encapsulated mRNA, immunogenicity, mice, primates
Summary of Study:
References: doi: 10.1016/j.omtn.2022.09.017
Contact Info: Yuta Suzuki: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2162253122002608?via%3Dihub=
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: hhc Data Creation Center, Tsukuba Research Laboratories, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan; Drug Discovery Platform, KAN Research Institute, Inc., 6-8-2 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan; Medicine Development Center, Tsukuba Research Laboratories, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan; Department of Immunology and Parasitology, Graduate School of Medicine, Tokushima University, Tokushima 770-8503, Japan.
Keywords: SARS-CoV-2, lipid nanoparticles, encapsulated mRNA, immunogenicity, mice, primates
Summary of Study:
References: doi: 10.1016/j.omtn.2022.09.017
Contact Info: Yuta Suzuki: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2162253122002608?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Duke University School of Medicine, Durham, NC; California National Primate Research Center; others.
Keywords: SARS-CoV-2, age-dependent responses, immune response, pathology, primates
Summary of Study: Age-dependent responses to SARS-CoV-2 in dam/infant pairs
References: doi: 10.4049/immunohorizons.2200075
Contact Info: Maria Blasi: [email protected]
URL: https://journals.aai.org/immunohorizons/article/6/12/851/237621/Dam-Infant-Rhes…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Duke University School of Medicine, Durham, NC; California National Primate Research Center; others.
Keywords: SARS-CoV-2, age-dependent responses, immune response, pathology, primates
Summary of Study: Age-dependent responses to SARS-CoV-2 in dam/infant pairs
References: doi: 10.4049/immunohorizons.2200075
Contact Info: Maria Blasi: [email protected]
URL: https://journals.aai.org/immunohorizons/article/6/12/851/237621/Dam-Infant-Rhes…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre/The Netherlands; NIAID; University Paris-Saclay, Inserm; Tulane National Primate Research Center; University of Pittsburgh School of Medicine; University of Pittsburgh Center for Vaccine Research; Texas Biomedical Research Institute; Frederick National Laboratory for Cancer Research
Keywords: SARS-CoV-2, advanced medical imaging, pathogenesis, primates
Summary of Study: The reviewers argue that advanced imaging tools add unique insight into poorly understood relationships of SARS-CV-2 exposure, infection, the host response, and disease presentation in the lungs.
References: PMID: 34955425 / doi: 10.1016/j.molmed.2021.12.001
Contact Info: Marieke Stammes: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1471491421003166?via%3Dihub=
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre/The Netherlands; NIAID; University Paris-Saclay, Inserm; Tulane National Primate Research Center; University of Pittsburgh School of Medicine; University of Pittsburgh Center for Vaccine Research; Texas Biomedical Research Institute; Frederick National Laboratory for Cancer Research
Keywords: SARS-CoV-2, advanced medical imaging, pathogenesis, primates
Summary of Study: The reviewers argue that advanced imaging tools add unique insight into poorly understood relationships of SARS-CV-2 exposure, infection, the host response, and disease presentation in the lungs.
References: PMID: 34955425 / doi: 10.1016/j.molmed.2021.12.001
Contact Info: Marieke Stammes: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1471491421003166?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine; Nanchang University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, CRISPR-RT–PCR assay, longitudinal analysis, mucosal, plasma, and breath samples, primates
Summary of Study: CRISPR-FDS may provide a means to evaluate systemic viral/viral RNA burden not detectable by RT-qPCR to improve diagnosis and better predict outcomes for SARS-CoV-2 infections.
References: PMID: 35108153 / doi: 10.1080/22221751.2038020
Contact Info: Tony Hu: tonyhu2tulane.edu
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2038020
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine; Nanchang University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, CRISPR-RT–PCR assay, longitudinal analysis, mucosal, plasma, and breath samples, primates
Summary of Study: CRISPR-FDS may provide a means to evaluate systemic viral/viral RNA burden not detectable by RT-qPCR to improve diagnosis and better predict outcomes for SARS-CoV-2 infections.
References: PMID: 35108153 / doi: 10.1080/22221751.2038020
Contact Info: Tony Hu: tonyhu2tulane.edu
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2038020
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; University of California, Irvine
Keywords: SARS-CoV-2, Vesicular Stomatitis Virus-Based Vaccine, route of administration, immune response, primates
Summary of Study: The VSV-SARS2-EBOV vaccine presents a vaccine with a high potential as a boosting option after the already-approved mRNA-based vaccine, because VSV-SARS2-EBOV elicits primarily a humoral response, in contrast to the predominantly T cell-driven immune response after mRNA vaccination.
References: PMID: 35012339 / doi: 10.1128/mbio.03379-21
Contact Info: Andrea Marzi: [email protected]
URL: https://journals.asm.org/doi/full/10.1128/mbio.03379-21?rfr_dat=cr_pub%20%200pu…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; University of California, Irvine
Keywords: SARS-CoV-2, Vesicular Stomatitis Virus-Based Vaccine, route of administration, immune response, primates
Summary of Study: The VSV-SARS2-EBOV vaccine presents a vaccine with a high potential as a boosting option after the already-approved mRNA-based vaccine, because VSV-SARS2-EBOV elicits primarily a humoral response, in contrast to the predominantly T cell-driven immune response after mRNA vaccination.
References: PMID: 35012339 / doi: 10.1128/mbio.03379-21
Contact Info: Andrea Marzi: [email protected]
URL: https://journals.asm.org/doi/full/10.1128/mbio.03379-21?rfr_dat=cr_pub%20%200pu…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Institute of Infectious Diseases, Tokyo; Kumamoto University; ID Pharma Co., Ltd.
Keywords: SARS-CoV-2, intranasal vaccine, non-S antigens, immune response, primates
Summary of Study: CD8+ T cell induction by intranasal vaccination with a vaccine expressing viral non-S antigens can result in NAb-independent control of SARS-CoV-2 infection.
References: PMID: 35233545 / doi: 10.1016/j.xcrm.2022.100520
Contact Info: Tetsuro Matano: [email protected]
URL: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00020-9?_retu…
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Institute of Infectious Diseases, Tokyo; Kumamoto University; ID Pharma Co., Ltd.
Keywords: SARS-CoV-2, intranasal vaccine, non-S antigens, immune response, primates
Summary of Study: CD8+ T cell induction by intranasal vaccination with a vaccine expressing viral non-S antigens can result in NAb-independent control of SARS-CoV-2 infection.
References: PMID: 35233545 / doi: 10.1016/j.xcrm.2022.100520
Contact Info: Tetsuro Matano: [email protected]
URL: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00020-9?_retu…
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Illinois College of Medicine
Keywords: SARS-CoV-2, transcriptomic profiling, lung endothelial cells, primates
Summary of Study: The specific genes that distinguished immuneEC and devEC populations in the NHP lungs after SARS-CoV-2 infection were different from the endotoxemic mouse lung. This may reflect either species differences or different injury-specific responses (bacterial endotoxin vs. SARS-CoV-2).
References: PMID: 35511435 / doi: 10.1172/jci.insight.158079
Contact Info: Lianghui Zhang: [email protected]; Jalees Rehman: [email protected]
URL: https://insight.jci.org/articles/view/158079
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Illinois College of Medicine
Keywords: SARS-CoV-2, transcriptomic profiling, lung endothelial cells, primates
Summary of Study: The specific genes that distinguished immuneEC and devEC populations in the NHP lungs after SARS-CoV-2 infection were different from the endotoxemic mouse lung. This may reflect either species differences or different injury-specific responses (bacterial endotoxin vs. SARS-CoV-2).
References: PMID: 35511435 / doi: 10.1172/jci.insight.158079
Contact Info: Lianghui Zhang: [email protected]; Jalees Rehman: [email protected]
URL: https://insight.jci.org/articles/view/158079
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Fred Hutchinson Cancer Research Center; Department of Medicine, University of Washington
Keywords: SARS-CoV-2, remdesivir, math modeling, antiviral potency, nasal passages, lungs, primates
Summary of Study: In rhesus macaques, the nonlinear forces governing SARS-CoV-2 viral load trajectories in the lung and nasal passages differ substantially in the presence of a partially effective antiviral therapy. To the extent that the rhesus macaque model approximates human infection, nasal viral load remains a promising surrogate endpoint marker but perhaps only in the context of a highly potent antiviral therapy.
References: PMID: 35634576 / doi: 10.1016/j.isci.2022.104448
Contact Info: Joshua Schiffer: [email protected]
URL: https://www.cell.com/iscience/fulltext/S2589-0042(22)00719-2?_returnURL=https%3…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Fred Hutchinson Cancer Research Center; Department of Medicine, University of Washington
Keywords: SARS-CoV-2, remdesivir, math modeling, antiviral potency, nasal passages, lungs, primates
Summary of Study: In rhesus macaques, the nonlinear forces governing SARS-CoV-2 viral load trajectories in the lung and nasal passages differ substantially in the presence of a partially effective antiviral therapy. To the extent that the rhesus macaque model approximates human infection, nasal viral load remains a promising surrogate endpoint marker but perhaps only in the context of a highly potent antiviral therapy.
References: PMID: 35634576 / doi: 10.1016/j.isci.2022.104448
Contact Info: Joshua Schiffer: [email protected]
URL: https://www.cell.com/iscience/fulltext/S2589-0042(22)00719-2?_returnURL=https%3…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shionogi & Co., Ltd.; Department of Pathology and Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan
Keywords: SARS-CoV-2, recombinant S-protein vaccine S-268019-b, immune response, primates
Summary of Study: Immunogenicity and protective efficacy of SARS-CoV-2 recombinant S-protein vaccine S-268019-b in cynomolgus monkeys
References: PMID: 35691872 PMCID: PMC9167832 DOI: 10.1016/j.vaccine.22.05.081
Contact Info: Hideki Hasegawa: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22007186?via%3Dihub=
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shionogi & Co., Ltd.; Department of Pathology and Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan
Keywords: SARS-CoV-2, recombinant S-protein vaccine S-268019-b, immune response, primates
Summary of Study: Immunogenicity and protective efficacy of SARS-CoV-2 recombinant S-protein vaccine S-268019-b in cynomolgus monkeys
References: PMID: 35691872 PMCID: PMC9167832 DOI: 10.1016/j.vaccine.22.05.081
Contact Info: Hideki Hasegawa: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22007186?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shanghai Zerun Biotech Co., Ltd.; numerous others
Keywords: SARS-CoV-2, recombinant vaccine, immunogenicity, virus variants, hamster, primates
Summary of Study: A potent, broadly protective vaccine against SARS-CoV-2 variants of concern.
References: doi: 10.1038/s41541-022-00571-0
Contact Info: Chenliang Zhou: [email protected]
URL: https://www.nature.com/articles/s41541-022-00571-0
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shanghai Zerun Biotech Co., Ltd.; numerous others
Keywords: SARS-CoV-2, recombinant vaccine, immunogenicity, virus variants, hamster, primates
Summary of Study: A potent, broadly protective vaccine against SARS-CoV-2 variants of concern.
References: doi: 10.1038/s41541-022-00571-0
Contact Info: Chenliang Zhou: [email protected]
URL: https://www.nature.com/articles/s41541-022-00571-0
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences; Fudan University; Shanghai King-Cell Biotechnology Co., Ltd.; Mabwell Bioscience Co., Ltd.; Shenzhen University; University of Chinese Academy of Sciences
Keywords: SARS-CoV-2, self-adjuvanting peptide vaccine, CoVac501, immune response, virus variants, primates
Summary of Study: CoVac501, a novel SARS-CoV-2 vaccine that is fully chemically synthesized and self-adjuvanting, provided potent protection for cynomolgus macaques against challenges from very high doses of SARS-CoV-2.
References: PMID: 35102138 / doi: 10.1038/s41421-021-00370-2
Contact Info: Qiuping Qin: [email protected]
URL: https://www.nature.com/articles/s41421-021-00370-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences; Fudan University; Shanghai King-Cell Biotechnology Co., Ltd.; Mabwell Bioscience Co., Ltd.; Shenzhen University; University of Chinese Academy of Sciences
Keywords: SARS-CoV-2, self-adjuvanting peptide vaccine, CoVac501, immune response, virus variants, primates
Summary of Study: CoVac501, a novel SARS-CoV-2 vaccine that is fully chemically synthesized and self-adjuvanting, provided potent protection for cynomolgus macaques against challenges from very high doses of SARS-CoV-2.
References: PMID: 35102138 / doi: 10.1038/s41421-021-00370-2
Contact Info: Qiuping Qin: [email protected]
URL: https://www.nature.com/articles/s41421-021-00370-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Pfizer; Icahn School of Medicine at Mount Sinai; Texas Biomedical Research Institute; New Iberia Research Center
Keywords: SARS-CoV-2, pathology, inflammation, Golden Syrian Hamster, primates
Summary of Study: Macaques may be appropriate for mechanistic studies of mild asymptomatic COVID-19 pneumonia and COVID-19-associated encephalitis, whereas Syrian hamsters may be more suited to study severe COVID-19 pneumonia.
References: PMID: 35128980 / doi: 10.1177/01926233211072767
Contact Info: Shambhunath Choudhary: [email protected]
URL: https://journals.sagepub.com/doi/full/10.1177/01926233211072767?rfr_dat=cr_pub%…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Pfizer; Icahn School of Medicine at Mount Sinai; Texas Biomedical Research Institute; New Iberia Research Center
Keywords: SARS-CoV-2, pathology, inflammation, Golden Syrian Hamster, primates
Summary of Study: Macaques may be appropriate for mechanistic studies of mild asymptomatic COVID-19 pneumonia and COVID-19-associated encephalitis, whereas Syrian hamsters may be more suited to study severe COVID-19 pneumonia.
References: PMID: 35128980 / doi: 10.1177/01926233211072767
Contact Info: Shambhunath Choudhary: [email protected]
URL: https://journals.sagepub.com/doi/full/10.1177/01926233211072767?rfr_dat=cr_pub%…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; Tongji Medical College of Huazhong University of Science & Technology
Keywords: SARS-CoV-2, infection, pathogenesis, virus variants, primates
Summary of Study: Delta variant of SARS-CoV-2 can effectively infect the Rhesus macaque.
References: PMID: 35279412 / doi: 10.1016/j.virs.2022.02.001
Contact Info: Zhiming Yuan: [email protected]; Chao Shan: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1995820X22000335?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; Tongji Medical College of Huazhong University of Science & Technology
Keywords: SARS-CoV-2, infection, pathogenesis, virus variants, primates
Summary of Study: Delta variant of SARS-CoV-2 can effectively infect the Rhesus macaque.
References: PMID: 35279412 / doi: 10.1016/j.virs.2022.02.001
Contact Info: Zhiming Yuan: [email protected]; Chao Shan: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1995820X22000335?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Fred Hutchinson Cancer Research Center; University of Washington; HDT Bio; NIAID; Washington National Primate Research Center
Keywords: SARS-CoV-2, phage-based deep mutational scanning, immune response, vaccination, primates
Summary of Study: Findings suggest that the antibody response to SARS-CoV-2 in macaques shares many features with humans, but with substantial differences in the recognition of certain epitopes and considerable individual variability in antibody escape profiles, suggesting a diverse repertoire of antibodies that can respond to major epitopes in both humans and macaques.
References: PMID: 35404959 / doi: 10.1371/journal.ppat.1010155
Contact Info: Julie Overbaugh: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010155
NHP Species: pigtail macaques, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Fred Hutchinson Cancer Research Center; University of Washington; HDT Bio; NIAID; Washington National Primate Research Center
Keywords: SARS-CoV-2, phage-based deep mutational scanning, immune response, vaccination, primates
Summary of Study: Findings suggest that the antibody response to SARS-CoV-2 in macaques shares many features with humans, but with substantial differences in the recognition of certain epitopes and considerable individual variability in antibody escape profiles, suggesting a diverse repertoire of antibodies that can respond to major epitopes in both humans and macaques.
References: PMID: 35404959 / doi: 10.1371/journal.ppat.1010155
Contact Info: Julie Overbaugh: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010155
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: USAMRIID; Henry M. Jackson Foundation for the Advancement of Military Medicine; Walter Reed Army Institute of Research
Keywords: SARS-CoV-2, spike ferritin nanoparticle vaccine, immune response, primates
Summary of Study: Two adjuvants were compared (ALFQ and AIOH3): Robust humoral and cellular immunological responses were observed for vaccinated animals, with the ALFQ-adjuvanted group generating a significantly higher response compared ot the AIOH3 group. Vaccination with either adjuvant resulted in fewer clinical signs of disease compared to controls, including a significant reduction in lesions and virus replication in the lungs.
References: PMID: 35632473 / doi: 10.3390/vaccines10050717
Contact Info: Jeffrey Smith: [email protected]; Jay Hooper: [email protected]; Keersten Ricks: [email protected]; Hannah King: [email protected]; Kristina Peachman: [email protected]; Alexandra Jay: [email protected]
URL: https://www.mdpi.com/2076-393X/10/5/717
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: USAMRIID; Henry M. Jackson Foundation for the Advancement of Military Medicine; Walter Reed Army Institute of Research
Keywords: SARS-CoV-2, spike ferritin nanoparticle vaccine, immune response, primates
Summary of Study: Two adjuvants were compared (ALFQ and AIOH3): Robust humoral and cellular immunological responses were observed for vaccinated animals, with the ALFQ-adjuvanted group generating a significantly higher response compared ot the AIOH3 group. Vaccination with either adjuvant resulted in fewer clinical signs of disease compared to controls, including a significant reduction in lesions and virus replication in the lungs.
References: PMID: 35632473 / doi: 10.3390/vaccines10050717
Contact Info: Jeffrey Smith: [email protected]; Jay Hooper: [email protected]; Keersten Ricks: [email protected]; Hannah King: [email protected]; Kristina Peachman: [email protected]; Alexandra Jay: [email protected]
URL: https://www.mdpi.com/2076-393X/10/5/717
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses; Jilin University First Hospital; Beijing Institute of Biotechnology; College of Basic Medical Sciences; Zhongshan Hospital Fudan University; Beijing Institute of Microbiology and Epidemiology; Shaanxi Normal University
Keywords: SARS-CoV-2, proteomics, metabolomics, pathology, immune response, primates
Summary of Study: An established COVID-19 model demonstrates that the innate immune response, neutrophil and platelet activation were dysregulated in infected NHPs, and these were greatly weakened in the most infected NHPs, which models moderately infected humans.
References: PMID: 35903092 / doi: 10.3389/fimmu.2022.954121
Contact Info: Yuwei Gao: [email protected]; Yan Liu: [email protected]; Xiaochang Xue: [email protected]; Hui Wang: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.954121/full
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses; Jilin University First Hospital; Beijing Institute of Biotechnology; College of Basic Medical Sciences; Zhongshan Hospital Fudan University; Beijing Institute of Microbiology and Epidemiology; Shaanxi Normal University
Keywords: SARS-CoV-2, proteomics, metabolomics, pathology, immune response, primates
Summary of Study: An established COVID-19 model demonstrates that the innate immune response, neutrophil and platelet activation were dysregulated in infected NHPs, and these were greatly weakened in the most infected NHPs, which models moderately infected humans.
References: PMID: 35903092 / doi: 10.3389/fimmu.2022.954121
Contact Info: Yuwei Gao: [email protected]; Yan Liu: [email protected]; Xiaochang Xue: [email protected]; Hui Wang: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.954121/full
Coronavirus Investigated: SARS-CoV-1, SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: The Scripps Research Institute; Massachusetts Institute of Technology; Alpha Genesis; University of California, San Diego; La Jolla Institute for Immunology; Howard Hughes Medical Institute; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University
Keywords: SARS-CoV-2, SARS-CoV-1, comparative studies, immune response, primates
Summary of Study: Using a two-shot protocol immunization with SARS-CoV-2 spike protein created strong serum receptor binding domain neutralizing antibody responses to both SARS-CoV-1 and SARS-CoV-2.
References: PMID: 35947674 / doi: 10.1126/scitranslmed.abl9605
Contact Info: Ian Wilson: [email protected]; Dennis Burton: [email protected]; Raiees Andrabi: [email protected]
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abl9605?rfr_dat=cr_pub%20…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: The Scripps Research Institute; Massachusetts Institute of Technology; Alpha Genesis; University of California, San Diego; La Jolla Institute for Immunology; Howard Hughes Medical Institute; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University
Keywords: SARS-CoV-2, SARS-CoV-1, comparative studies, immune response, primates
Summary of Study: Using a two-shot protocol immunization with SARS-CoV-2 spike protein created strong serum receptor binding domain neutralizing antibody responses to both SARS-CoV-1 and SARS-CoV-2.
References: PMID: 35947674 / doi: 10.1126/scitranslmed.abl9605
Contact Info: Ian Wilson: [email protected]; Dennis Burton: [email protected]; Raiees Andrabi: [email protected]
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abl9605?rfr_dat=cr_pub%20…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences & Peking Union Medical College; Beijing Engineering Research Center of Protein and Antibody, Sinocelltech Ltd
Keywords: SARS-CoV-2, nebulized neutralizing antibody, inhalation, mice, primates
Summary of Study: Feasibility of nebulized antibodies inhalation delivery
References: doi: 10.1007/s11095-022-03340-9
Contact Info: [email protected]
URL: https://link.springer.com/article/10.1007/s11095-022-03340-9
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences & Peking Union Medical College; Beijing Engineering Research Center of Protein and Antibody, Sinocelltech Ltd
Keywords: SARS-CoV-2, nebulized neutralizing antibody, inhalation, mice, primates
Summary of Study: Feasibility of nebulized antibodies inhalation delivery
References: doi: 10.1007/s11095-022-03340-9
Contact Info: [email protected]
URL: https://link.springer.com/article/10.1007/s11095-022-03340-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: Gujarat Biotechnology Research Centre (GBRC), India; Kamdhenu University, Gujarat, India; University of California Santa Barbara, Santa Barbara, CA.
Keywords: SARS-CoV-2, surveillance, RT-PCR, several animal species, primates
Summary of Study: Highlights transmission of SARS-CoV-2 infection from human to animals and suggests being watchful for zoonosis.
References: doi: 10.3390/ijerph192114391
Contact Info: Arunkumar Patel: [email protected]
URL: https://www.mdpi.com/1660-4601/19/21/14391
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: Gujarat Biotechnology Research Centre (GBRC), India; Kamdhenu University, Gujarat, India; University of California Santa Barbara, Santa Barbara, CA.
Keywords: SARS-CoV-2, surveillance, RT-PCR, several animal species, primates
Summary of Study: Highlights transmission of SARS-CoV-2 infection from human to animals and suggests being watchful for zoonosis.
References: doi: 10.3390/ijerph192114391
Contact Info: Arunkumar Patel: [email protected]
URL: https://www.mdpi.com/1660-4601/19/21/14391
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane School of Medicine
Keywords: SARS-CoV-2, aerosol or intra-tracheal/intra-nasal infection, viral load, inflammation, primates
Summary of Study: Cellular mechanisms underlying acute respiratory distress syndrome
References: doi: 10.1038/s42003-022-04310-y
Contact Info: Namita Rout: [email protected]
URL: https://www.nature.com/articles/s42003-022-04310-y
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane School of Medicine
Keywords: SARS-CoV-2, aerosol or intra-tracheal/intra-nasal infection, viral load, inflammation, primates
Summary of Study: Cellular mechanisms underlying acute respiratory distress syndrome
References: doi: 10.1038/s42003-022-04310-y
Contact Info: Namita Rout: [email protected]
URL: https://www.nature.com/articles/s42003-022-04310-y
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Emory University; University of Sao Paulo School of Medicine; Butantan Institute; La Jolla Institute for Immunology
Keywords: SARS-CoV-2, DNA vaccine HIVBr18, HLA class II vaccine epitopes, immunity, humans and primates
Summary of Study: Results provide preliminary proof of concept that immunization with a vaccine encoding epitopes with high and redundant coverage of the human population can elicit potent T cell responses to multiple epitopes, across species and MHC barriers.
References: PMID: 34961636 / doi: 10.1016/j.vaccine.2021.11.076
Contact Info: Edecio Cunha-Neto: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21015504?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Emory University; University of Sao Paulo School of Medicine; Butantan Institute; La Jolla Institute for Immunology
Keywords: SARS-CoV-2, DNA vaccine HIVBr18, HLA class II vaccine epitopes, immunity, humans and primates
Summary of Study: Results provide preliminary proof of concept that immunization with a vaccine encoding epitopes with high and redundant coverage of the human population can elicit potent T cell responses to multiple epitopes, across species and MHC barriers.
References: PMID: 34961636 / doi: 10.1016/j.vaccine.2021.11.076
Contact Info: Edecio Cunha-Neto: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21015504?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medicine Sciences & Peking Union Medical College; National Institute for Viral Disease Control and Prevention
Keywords: SARS-CoV-2, heterologous vaccines, intradermal administration, immune response, primates
Summary of Study: This study reports a new heterologous prime-boost strategy of intradermal immunization with the inactivated vaccine and K-S antigen. This strategy can significantly increase the neutralizing antibody titers and promote specific T cell responses in mice and macaques.
References: PMID: 34931939 / doi: 10.1080/22221751.2021807https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
Contact Info: Wenbo Xu: [email protected]; Qihan Li: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medicine Sciences & Peking Union Medical College; National Institute for Viral Disease Control and Prevention
Keywords: SARS-CoV-2, heterologous vaccines, intradermal administration, immune response, primates
Summary of Study: This study reports a new heterologous prime-boost strategy of intradermal immunization with the inactivated vaccine and K-S antigen. This strategy can significantly increase the neutralizing antibody titers and promote specific T cell responses in mice and macaques.
References: PMID: 34931939 / doi: 10.1080/22221751.2021807https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
Contact Info: Wenbo Xu: [email protected]; Qihan Li: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine
Keywords: SARS-CoV-2, virus genome, gut, virus evolution, primates
Summary of Study: Previous reports that an intact furin cleavage site is important for infection in vivo were confirmed in this study. Additionally, three mutations were identified that may represent an adaptation of SARS-CoV2 to African green monkeys or to NHP generally.
References: PMID: 35062281 / doi: 10.3390/v14010077
Contact Info: Nicholas Maness: [email protected]
URL: https://www.mdpi.com/1999-4915/14/1/77
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine
Keywords: SARS-CoV-2, virus genome, gut, virus evolution, primates
Summary of Study: Previous reports that an intact furin cleavage site is important for infection in vivo were confirmed in this study. Additionally, three mutations were identified that may represent an adaptation of SARS-CoV2 to African green monkeys or to NHP generally.
References: PMID: 35062281 / doi: 10.3390/v14010077
Contact Info: Nicholas Maness: [email protected]
URL: https://www.mdpi.com/1999-4915/14/1/77
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Shanghai Jiao Tong University; Westlake University, Hangzhou; University of Texas; Jecho Biopharmaceuticals; Jecho Laboratories; Zhengzhou University People's Hospital
Keywords: SARS-CoV-2, virus variants, neutralizing monoclonal antibodies, immune response, mice, primates
Summary of Study: An antibody designated as 2G1 efficiently neutralized all VOCs including widely spread Alpha, Beta, Gamma, Delta variants and Cluster 5, a variant with Y453F substitution that once caused public concern due to its zoonotic characteristics.
References: PMID: 35169121 / doi: 10.1038/s41421-022-00381-7
Contact Info: Lei Han: [email protected]
URL: https://www.nature.com/articles/s41421-022-00381-7
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Shanghai Jiao Tong University; Westlake University, Hangzhou; University of Texas; Jecho Biopharmaceuticals; Jecho Laboratories; Zhengzhou University People's Hospital
Keywords: SARS-CoV-2, virus variants, neutralizing monoclonal antibodies, immune response, mice, primates
Summary of Study: An antibody designated as 2G1 efficiently neutralized all VOCs including widely spread Alpha, Beta, Gamma, Delta variants and Cluster 5, a variant with Y453F substitution that once caused public concern due to its zoonotic characteristics.
References: PMID: 35169121 / doi: 10.1038/s41421-022-00381-7
Contact Info: Lei Han: [email protected]
URL: https://www.nature.com/articles/s41421-022-00381-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Peking University; Chinese Academy of Medical Sciences and Peking Union Medical College; WHO Collaborating Center for Standardization and Evaluation of Biologicals
Keywords: SARS-CoV-2, circRNA vaccine, neutralizing antibodies, virus variants, primates
Summary of Study: CircRNA/RBD-Omicron vaccine induced effective neutralizing antibodies against the Omicron but not the Delta variant. In contrast, the circRNA/RBD-Delta vaccine protected against both Delta and Omicron or functioned as a booster after two doses of either native- or Delta-specific vaccination, making it a favorable choice against the current variants of concern of SARS-CoV-2.
References: PMID: 35460644 / doi: 10.1016/j.cell.2022.03.044
Contact Info: Wensheng Wei: [email protected]
URL: https://www.cell.com/cell/fulltext/S0092-8674(22)00394-4?_returnURL=https%3A//l…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Peking University; Chinese Academy of Medical Sciences and Peking Union Medical College; WHO Collaborating Center for Standardization and Evaluation of Biologicals
Keywords: SARS-CoV-2, circRNA vaccine, neutralizing antibodies, virus variants, primates
Summary of Study: CircRNA/RBD-Omicron vaccine induced effective neutralizing antibodies against the Omicron but not the Delta variant. In contrast, the circRNA/RBD-Delta vaccine protected against both Delta and Omicron or functioned as a booster after two doses of either native- or Delta-specific vaccination, making it a favorable choice against the current variants of concern of SARS-CoV-2.
References: PMID: 35460644 / doi: 10.1016/j.cell.2022.03.044
Contact Info: Wensheng Wei: [email protected]
URL: https://www.cell.com/cell/fulltext/S0092-8674(22)00394-4?_returnURL=https%3A//l…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: SUNY Upstate Medical University; Walter Reed Army Institute of Research; NIAID
Keywords: SARS-CoV-2, mRNA-1273 vaccine, respiratory tract, inflammation, primates
Summary of Study: This study defines the lower respiratory tract cellular and transcriptional signature associated with SARS-CoV-2 in macaques using two distinct viral variants, and identifies conserved signatures of vaccine-elicited protection from infection-attendant inflammation. These date emphasize the contribution of inflammatory/migratory DCs and macrophages to lower respiratory tract inflammation following SARS-CoV-2 infection, and define a critical relationship between antibody titers, post-challenge viral burden, and broad infection-elicited inflammation.
References: PMID: 35653196 / doi: 10.1172/jci.insight.160039
Contact Info: Robert Seder: Robert Seder: [email protected]
URL: https://insight.jci.org/articles/view/160039
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: SUNY Upstate Medical University; Walter Reed Army Institute of Research; NIAID
Keywords: SARS-CoV-2, mRNA-1273 vaccine, respiratory tract, inflammation, primates
Summary of Study: This study defines the lower respiratory tract cellular and transcriptional signature associated with SARS-CoV-2 in macaques using two distinct viral variants, and identifies conserved signatures of vaccine-elicited protection from infection-attendant inflammation. These date emphasize the contribution of inflammatory/migratory DCs and macrophages to lower respiratory tract inflammation following SARS-CoV-2 infection, and define a critical relationship between antibody titers, post-challenge viral burden, and broad infection-elicited inflammation.
References: PMID: 35653196 / doi: 10.1172/jci.insight.160039
Contact Info: Robert Seder: Robert Seder: [email protected]
URL: https://insight.jci.org/articles/view/160039
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: CAS Key Laboratory of Computational Biology; Shanghai Institute of Nutrition and Health; University of Chinese Academy of Sciences; Chinese Academy of Sciences; Max Planck Institute of Psychiatry, Proteomics and Biomarkers
Keywords: SARS-CoV-2, circadian gene networks, transcriptome, primates
Summary of Study: Many mammalian genes are controlled by a central clock under circadian control, resulting in a rhythmic expression of genes involved in homeostasis. SARS-CoV-2 related genes are also rhythmically expressed, suggesting close interactions with circadian regulators.
References: PMID: 35906476 / doi: 10.1038/s42003-022-03722-0
Contact Info: Guang-Zhong Wang: [email protected]
URL: https://www.nature.com/articles/s42003-022-03722-0
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: CAS Key Laboratory of Computational Biology; Shanghai Institute of Nutrition and Health; University of Chinese Academy of Sciences; Chinese Academy of Sciences; Max Planck Institute of Psychiatry, Proteomics and Biomarkers
Keywords: SARS-CoV-2, circadian gene networks, transcriptome, primates
Summary of Study: Many mammalian genes are controlled by a central clock under circadian control, resulting in a rhythmic expression of genes involved in homeostasis. SARS-CoV-2 related genes are also rhythmically expressed, suggesting close interactions with circadian regulators.
References: PMID: 35906476 / doi: 10.1038/s42003-022-03722-0
Contact Info: Guang-Zhong Wang: [email protected]
URL: https://www.nature.com/articles/s42003-022-03722-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Institutes for Food and Drug Control, Beijing; Guangzhou Laboratory; Kunming National High-level Biosafety Primate Research Center
Keywords: SARS-CoV-2, vaccine, chimpanzee adenovirus vector, immune response, mice, primates
Summary of Study: Using a chimpanzee adenovirus vectored vaccine expressing SARS-CoV2 spike in combination with an inactivated vaccine reduced lung injury risk while maintaining flexibility of the antibody regulation system.
References: PMID: 36059554 / doi: 10.3389/fimmu.2022.949248
Contact Info: Junzhi Wang: [email protected]; Zhenglun Liang: [email protected]; Miao Xu: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.949248/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Institutes for Food and Drug Control, Beijing; Guangzhou Laboratory; Kunming National High-level Biosafety Primate Research Center
Keywords: SARS-CoV-2, vaccine, chimpanzee adenovirus vector, immune response, mice, primates
Summary of Study: Using a chimpanzee adenovirus vectored vaccine expressing SARS-CoV2 spike in combination with an inactivated vaccine reduced lung injury risk while maintaining flexibility of the antibody regulation system.
References: PMID: 36059554 / doi: 10.3389/fimmu.2022.949248
Contact Info: Junzhi Wang: [email protected]; Zhenglun Liang: [email protected]; Miao Xu: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.949248/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane University, Memorial Sloan Kettering Cancer Ctr, Weill Cornell Medical College, Instuto de Química Pontificia Universidad Católica de Valparaíso
Keywords: SARS-CoV-2, urokinase plasminogen activator receptor, renal dysfunction, pathology, primates
Summary of Study: Elevated soluble urokinase plasminogen activator receptor
References: doi: 10.1111/jmp.12626
Contact Info: Minolfa Prieto: [email protected]
URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/jmp.12626
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane University, Memorial Sloan Kettering Cancer Ctr, Weill Cornell Medical College, Instuto de Química Pontificia Universidad Católica de Valparaíso
Keywords: SARS-CoV-2, urokinase plasminogen activator receptor, renal dysfunction, pathology, primates
Summary of Study: Elevated soluble urokinase plasminogen activator receptor
References: doi: 10.1111/jmp.12626
Contact Info: Minolfa Prieto: [email protected]
URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/jmp.12626
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; Gilead Sciences
Keywords: SARS-CoV-2, Remdesivir, subcutaneous administration, pathology, virus load, primates
Summary of Study: Early subcutaneous administration of remdesivir can protect from lower respiratory tract disease caused by SARS-CoV-2.
References: PMID: 35032523 / doi: 10.1016/j.antiviral.2022.105246
Contact Info: Emmie de Wit: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0166354222000146?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; Gilead Sciences
Keywords: SARS-CoV-2, Remdesivir, subcutaneous administration, pathology, virus load, primates
Summary of Study: Early subcutaneous administration of remdesivir can protect from lower respiratory tract disease caused by SARS-CoV-2.
References: PMID: 35032523 / doi: 10.1016/j.antiviral.2022.105246
Contact Info: Emmie de Wit: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0166354222000146?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Janssen Vaccines and Prevention; Ragon Institute of MGH, MIT and Harvard; BIOQUAL; Amsterdam University Medical Center
Keywords: SARS-CoV-2, homologous or variant booster vaccine, humoral and cellular immune responses, primates
Summary of Study: A late boost with Ad26.COV2.S or Ad26.COV2.S.351 resulted in a marked increase in humoral and cellular immune responses that were highly cross-reactive across multiple SARS-CoV-2 variants in rhesus macaques.
References: PMID: 35191769 / doi: 10.1126/scitranslmed.bm4996
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abm4996?rfr_dat=cr_pub%20…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Janssen Vaccines and Prevention; Ragon Institute of MGH, MIT and Harvard; BIOQUAL; Amsterdam University Medical Center
Keywords: SARS-CoV-2, homologous or variant booster vaccine, humoral and cellular immune responses, primates
Summary of Study: A late boost with Ad26.COV2.S or Ad26.COV2.S.351 resulted in a marked increase in humoral and cellular immune responses that were highly cross-reactive across multiple SARS-CoV-2 variants in rhesus macaques.
References: PMID: 35191769 / doi: 10.1126/scitranslmed.bm4996
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abm4996?rfr_dat=cr_pub%20…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre; Department of Pathology, Amsterdam UMC; Utrecht University; Leiden University Medical Center; University of Twente
Keywords: SARS-CoV-2, neuropathology, immune response, primates
Summary of Study: Data highlight the potential of SARS-CoV-2 to cause pathology in the brain of macaques. A range of neurological abnormalities were observed, including hypermetabolic pituitary gland, alpha-synuclein inclusions, activated microglia in the brain parenchyma, and infiltrating T-cells.
References: PMID: 35458506 / doi: 10.3390/v14040776
Contact Info: Ernst Verschoor: [email protected]
URL: https://www.mdpi.com/1999-4915/14/4/776
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre; Department of Pathology, Amsterdam UMC; Utrecht University; Leiden University Medical Center; University of Twente
Keywords: SARS-CoV-2, neuropathology, immune response, primates
Summary of Study: Data highlight the potential of SARS-CoV-2 to cause pathology in the brain of macaques. A range of neurological abnormalities were observed, including hypermetabolic pituitary gland, alpha-synuclein inclusions, activated microglia in the brain parenchyma, and infiltrating T-cells.
References: PMID: 35458506 / doi: 10.3390/v14040776
Contact Info: Ernst Verschoor: [email protected]
URL: https://www.mdpi.com/1999-4915/14/4/776
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Universite Paris-Saclay, INSERM, CEA; Life and Soft; IRCCS Ospedale San Raffaele; Institut Pasteur
Keywords: SARS-CoV-2, neonate animals, immune response, pathology, primates
Summary of Study: This pilot study demonstrates that neonatal NHPs are a relevant model for pediatric SARS-CoV-2 infection.
References: PMID: 35603150 / doi: 10.3389/fimmu.2022.855230
Contact Info: Nabila Seddiki: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.855230/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Universite Paris-Saclay, INSERM, CEA; Life and Soft; IRCCS Ospedale San Raffaele; Institut Pasteur
Keywords: SARS-CoV-2, neonate animals, immune response, pathology, primates
Summary of Study: This pilot study demonstrates that neonatal NHPs are a relevant model for pediatric SARS-CoV-2 infection.
References: PMID: 35603150 / doi: 10.3389/fimmu.2022.855230
Contact Info: Nabila Seddiki: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.855230/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Tulane University School of Medicine; Beijing Forestry University; Beijing Institute of Lifeomics; Ochsner Clinic Foundation; University of Texas Southwestern Medical Center; Tulane National Primate Research Center
Keywords: SARS-CoV-2, peptide microarrays, neutralizing antibodies, vaccine, primates
Summary of Study: Linear peptide epitopes detected by immunoglobulins after infection have been localized to functionally important virus regions, which can be used to inform vaccine evaluation and targets for site-specific therapy.
References: PMID: 35928300 / doi: 10.34133/2022/9769803
Contact Info: Xiaobo Yu: [email protected]; Tony Hu: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297724/
NHP Species: african green monkeys, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Tulane University School of Medicine; Beijing Forestry University; Beijing Institute of Lifeomics; Ochsner Clinic Foundation; University of Texas Southwestern Medical Center; Tulane National Primate Research Center
Keywords: SARS-CoV-2, peptide microarrays, neutralizing antibodies, vaccine, primates
Summary of Study: Linear peptide epitopes detected by immunoglobulins after infection have been localized to functionally important virus regions, which can be used to inform vaccine evaluation and targets for site-specific therapy.
References: PMID: 35928300 / doi: 10.34133/2022/9769803
Contact Info: Xiaobo Yu: [email protected]; Tony Hu: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297724/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Betuvax LLC; Lomonosov Moscow State University; Clinical Excellence Group LLC; I.I. Mechnikov North-Western State Medical University; PJSC Human Stem Cells Institute; Center of Genetics and Reproductive Medicine; Sechenov First Moscow State Medical University; Biotechnology Developments LLC; Ministry of Health of the Russian Federation
Keywords: SARS-CoV-2, subunit vaccine, “Betuvax-CoV-2”, preclinical studies, several animal species, primates
Summary of Study: A vaccine developed as a subunit that contains a recombinant receptor-binding domain fusion protein and virus-like nanoparticles demonstrates effective protection through COVID-19 neutralizing antibody production and conferring infection and lung damage protection.
References: PMID: 36016181 / doi: 10.3390/vaccines10081290
Contact Info: Anna Vakrusheva: [email protected]
URL: https://www.mdpi.com/2076-393X/10/8/1290
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Betuvax LLC; Lomonosov Moscow State University; Clinical Excellence Group LLC; I.I. Mechnikov North-Western State Medical University; PJSC Human Stem Cells Institute; Center of Genetics and Reproductive Medicine; Sechenov First Moscow State Medical University; Biotechnology Developments LLC; Ministry of Health of the Russian Federation
Keywords: SARS-CoV-2, subunit vaccine, “Betuvax-CoV-2”, preclinical studies, several animal species, primates
Summary of Study: A vaccine developed as a subunit that contains a recombinant receptor-binding domain fusion protein and virus-like nanoparticles demonstrates effective protection through COVID-19 neutralizing antibody production and conferring infection and lung damage protection.
References: PMID: 36016181 / doi: 10.3390/vaccines10081290
Contact Info: Anna Vakrusheva: [email protected]
URL: https://www.mdpi.com/2076-393X/10/8/1290
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Wuhan Institute of Virology; Chinese Academy of Science; Wuhan National Biosafety Library, others
Keywords: SARS-CoV-2, testicular pathological damage, inflammation, primates
Summary of Study: SARS-CoV-2 infection induces testicular injury in Rhesus macaque
References: 10.1016/j.virs.2022.10.008
Contact Info: Z. Wuan: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1995820X22001833?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Wuhan Institute of Virology; Chinese Academy of Science; Wuhan National Biosafety Library, others
Keywords: SARS-CoV-2, testicular pathological damage, inflammation, primates
Summary of Study: SARS-CoV-2 infection induces testicular injury in Rhesus macaque
References: 10.1016/j.virs.2022.10.008
Contact Info: Z. Wuan: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1995820X22001833?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Praesidium Bioscience, Inc., New York, NY; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Intima Bioscience, Inc., New York, NY; Ragon Institute of Massachusetts General Hospital, Massac
Keywords: SARS-CoV-2, CRISPR, stem cell, iPSC, vaccine, universal cell, primates
Summary of Study: A genetically engineered, stem-cell-derived cellular vaccine
References: doi: 10.1016/j.xcrm.2022.100843
Contact Info: Tom Henley: [email protected]; Dan H. Barouch: dbarouch@[email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379122004074?via%3Dihub=
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Praesidium Bioscience, Inc., New York, NY; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Intima Bioscience, Inc., New York, NY; Ragon Institute of Massachusetts General Hospital, Massac
Keywords: SARS-CoV-2, CRISPR, stem cell, iPSC, vaccine, universal cell, primates
Summary of Study: A genetically engineered, stem-cell-derived cellular vaccine
References: doi: 10.1016/j.xcrm.2022.100843
Contact Info: Tom Henley: [email protected]; Dan H. Barouch: dbarouch@[email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379122004074?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; Yerkes National Primate Research Center; Emory University School of Medicine; Bioqual; Moderna, Inc.
Keywords: SARS-CoV-2, mRNA-1273 vaccination, longitudinal study, immune response, primates
Summary of Study: While mRNA-1273 provided durable protection against B.1.617.2 challenge, control of the virus was briefly delayed in the lungs and limited in the nose, which may provide the virus with a greater opportunity for transmission.
References: PMID: 34921774 / doi: 10.1016/j.cell.2021.12.002
Contact Info: Robert Seder: [email protected]; Daniel Douek: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0092867421014057?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; Yerkes National Primate Research Center; Emory University School of Medicine; Bioqual; Moderna, Inc.
Keywords: SARS-CoV-2, mRNA-1273 vaccination, longitudinal study, immune response, primates
Summary of Study: While mRNA-1273 provided durable protection against B.1.617.2 challenge, control of the virus was briefly delayed in the lungs and limited in the nose, which may provide the virus with a greater opportunity for transmission.
References: PMID: 34921774 / doi: 10.1016/j.cell.2021.12.002
Contact Info: Robert Seder: [email protected]; Daniel Douek: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0092867421014057?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; University of Oxford
Keywords: SARS-CoV-2, age-specific immune responses, viral load, primates
Summary of Study: Despite similar disease outcomes, multiomics profiling suggests that age may delay or impair antiviral cellular immune responses and delay efficient return to homeostasis.
References: PMID: 35039442 / doi: 10.26508/lsa.202101314
Contact Info: Emmie de Wit: [email protected]
URL: https://www.life-science-alliance.org/content/5/4/e202101314
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; University of Oxford
Keywords: SARS-CoV-2, age-specific immune responses, viral load, primates
Summary of Study: Despite similar disease outcomes, multiomics profiling suggests that age may delay or impair antiviral cellular immune responses and delay efficient return to homeostasis.
References: PMID: 35039442 / doi: 10.26508/lsa.202101314
Contact Info: Emmie de Wit: [email protected]
URL: https://www.life-science-alliance.org/content/5/4/e202101314
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Paris-East Creteil University; Universite Paris-Saclay Fontenay-aux-Roses; CEA-INSERM, University of Lille; Universite de Lyon; Centre de Recherche en Cancerologie de Lyon; Institut Curie; Justus Liebig University
Keywords: SARS-CoV-2, lung cell senescence, RNA analysis, pathology, humans, primates
Summary of Study: Cell senescence was monitored in cynomolgus macaques to evaluate potential links between SARS-CoV-2 infection and aging. Data constitute the first evidence of temporal and topographic relations between senescent cell accumulation and pulmonary lesions induced by SARS-CoV-2.
References: PMID: 34648725 / doi: 10.1165/rcmb.2021-0205LE
Contact Info: Serge Adnot: [email protected]
URL: https://www.atsjournals.org/doi/10.1165/rcmb.2021-0205LE?url_ver=Z39.88-2003&rf…
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Paris-East Creteil University; Universite Paris-Saclay Fontenay-aux-Roses; CEA-INSERM, University of Lille; Universite de Lyon; Centre de Recherche en Cancerologie de Lyon; Institut Curie; Justus Liebig University
Keywords: SARS-CoV-2, lung cell senescence, RNA analysis, pathology, humans, primates
Summary of Study: Cell senescence was monitored in cynomolgus macaques to evaluate potential links between SARS-CoV-2 infection and aging. Data constitute the first evidence of temporal and topographic relations between senescent cell accumulation and pulmonary lesions induced by SARS-CoV-2.
References: PMID: 34648725 / doi: 10.1165/rcmb.2021-0205LE
Contact Info: Serge Adnot: [email protected]
URL: https://www.atsjournals.org/doi/10.1165/rcmb.2021-0205LE?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Central Florida; Tulane National Primate Research Center
Keywords: SARS-CoV-2, pathology, heart, immune response, primates
Summary of Study: SARS-CoV-2 infection is characterized by an exaggerated inflammatory immune response in the heart, which possibly contributes to myocardial remodeling and subsequent fibrosis.
References: PMID: 35203260 / doi: 10.3390/cells11040611
Contact Info: Manish Kumar Gupta: [email protected]
URL: https://www.mdpi.com/2073-4409/11/4/611
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Central Florida; Tulane National Primate Research Center
Keywords: SARS-CoV-2, pathology, heart, immune response, primates
Summary of Study: SARS-CoV-2 infection is characterized by an exaggerated inflammatory immune response in the heart, which possibly contributes to myocardial remodeling and subsequent fibrosis.
References: PMID: 35203260 / doi: 10.3390/cells11040611
Contact Info: Manish Kumar Gupta: [email protected]
URL: https://www.mdpi.com/2073-4409/11/4/611
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Inovio Pharmaceuticals; The Wistar Institute
Keywords: SARS-CoV-2, DNA vaccine, prime-boost vaccination, immune response, primates
Summary of Study: Illustrates the durability of immunity following vaccination with synthetic DNA vaccine encoding the wild-type Spike protein, INO-4800, and additionally supports the use of either INO-4800 or INO-4802 in prime-boost regimens.
References: PMID: 35428500 / doi: 10.1016/j.vaccine.2022.03.060
Contact Info: Kate Broderick: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22003681?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Inovio Pharmaceuticals; The Wistar Institute
Keywords: SARS-CoV-2, DNA vaccine, prime-boost vaccination, immune response, primates
Summary of Study: Illustrates the durability of immunity following vaccination with synthetic DNA vaccine encoding the wild-type Spike protein, INO-4800, and additionally supports the use of either INO-4800 or INO-4802 in prime-boost regimens.
References: PMID: 35428500 / doi: 10.1016/j.vaccine.2022.03.060
Contact Info: Kate Broderick: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22003681?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Guangzhou Medical University; Macau University of Science and Technology; St. Januario Central Hospital Macau
Keywords: SARS-CoV-2, homologous or heterogenous vaccination boosters, virus variants, primates
Summary of Study: The Omicron BA.1 variant showed little sensitivity to all of the neutralizing antibodies evaluated in this study, adding to the emerging body of evidence that the resistance to neutralizing antibodies is conferred largely by the mutations in the RBD, since pseudovirus harboring additional spike protein mutations did not significantly change the resistance to neutralizing activity. A recombinant RBD protein vaccine may be a promising approach for future vaccine development.
References: PMID: 35592756 / doi: 10.1002/mco2.143
Contact Info: Kang Zhang: [email protected]; Gen Li: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095991/
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Guangzhou Medical University; Macau University of Science and Technology; St. Januario Central Hospital Macau
Keywords: SARS-CoV-2, homologous or heterogenous vaccination boosters, virus variants, primates
Summary of Study: The Omicron BA.1 variant showed little sensitivity to all of the neutralizing antibodies evaluated in this study, adding to the emerging body of evidence that the resistance to neutralizing antibodies is conferred largely by the mutations in the RBD, since pseudovirus harboring additional spike protein mutations did not significantly change the resistance to neutralizing activity. A recombinant RBD protein vaccine may be a promising approach for future vaccine development.
References: PMID: 35592756 / doi: 10.1002/mco2.143
Contact Info: Kang Zhang: [email protected]; Gen Li: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095991/
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Affinivax; Ragon Institute of MGH, MIT, and Harvard; Boston Children's Hospital
Keywords: SARS-CoV-2, multiple antigen-presenting system vaccine, pathology, primates
Summary of Study: Multiple Antigen-Presenting System is a novel way to create a vaccine presenting proteins on a polymer and is able to induce antibody formation and reduce viral load in NHPS.
References: PMID: 35891233 / doi: 10.3390/vaccines10071069
Contact Info: Gilles Besin: [email protected]
URL: https://www.mdpi.com/2076-393X/10/7/1069
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Affinivax; Ragon Institute of MGH, MIT, and Harvard; Boston Children's Hospital
Keywords: SARS-CoV-2, multiple antigen-presenting system vaccine, pathology, primates
Summary of Study: Multiple Antigen-Presenting System is a novel way to create a vaccine presenting proteins on a polymer and is able to induce antibody formation and reduce viral load in NHPS.
References: PMID: 35891233 / doi: 10.3390/vaccines10071069
Contact Info: Gilles Besin: [email protected]
URL: https://www.mdpi.com/2076-393X/10/7/1069
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Washington; Stanford University School of Medicine; University of Louisiana at Lafayette; Washington University School of Medicine
Keywords: SARS-CoV-2, vaccine, immune response, mice, primates
Summary of Study: Non-human primates and humans are better models than mice when looking at the potency of neutralizing antibody responses from vaccine as their immune and caution should be used when generalizing data from mouse models.
References: PMID: 35988541 / doi: 10.1016/j.celrep.2022.111299
Contact Info: David Veesler: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2211124722011196?via%3Dihub=
NHP Species: pigtail macaques, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Washington; Stanford University School of Medicine; University of Louisiana at Lafayette; Washington University School of Medicine
Keywords: SARS-CoV-2, vaccine, immune response, mice, primates
Summary of Study: Non-human primates and humans are better models than mice when looking at the potency of neutralizing antibody responses from vaccine as their immune and caution should be used when generalizing data from mouse models.
References: PMID: 35988541 / doi: 10.1016/j.celrep.2022.111299
Contact Info: David Veesler: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2211124722011196?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID Laboratory of Virology and NIAID Rocky Mountain Veterinary Branch, Hamilton, MT
Keywords: SARS-CoV-2, pathology, virus variants, primates
Summary of Study: Omicron BA.1 and BA.2 are attenuated in rhesus macaques as compared to Delta
References: doi: 10.1126/sciadv.ade1860
Contact Info: Kyle Rosenke: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.ade1860
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID Laboratory of Virology and NIAID Rocky Mountain Veterinary Branch, Hamilton, MT
Keywords: SARS-CoV-2, pathology, virus variants, primates
Summary of Study: Omicron BA.1 and BA.2 are attenuated in rhesus macaques as compared to Delta
References: doi: 10.1126/sciadv.ade1860
Contact Info: Kyle Rosenke: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.ade1860
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Medicago Inc.; Stanford University School of Medicine; Tulane National Primate Research Center; Tulane University School of Medicine; Research Institute of the McGill University Health Centre
Keywords: SARS-CoV-2, unadjuvanted and adjuvanted formulations, recombinant plant-derived virus-like particle vaccine, safety, immune response, primates
Summary of Study: A VLP bearing a SARS-CoV-2 spike protein vaccine candidate formulated with Adjuvant System 03 (AS03) was shown to be safe and effective and was therefore selected for vaccine development and clinical trials.
References: PMID: 34983950 / doi: 10.1038/s41423-021-00809-2
Contact Info: Brian Ward: [email protected]
URL: https://www.nature.com/articles/s41423-021-00809-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Medicago Inc.; Stanford University School of Medicine; Tulane National Primate Research Center; Tulane University School of Medicine; Research Institute of the McGill University Health Centre
Keywords: SARS-CoV-2, unadjuvanted and adjuvanted formulations, recombinant plant-derived virus-like particle vaccine, safety, immune response, primates
Summary of Study: A VLP bearing a SARS-CoV-2 spike protein vaccine candidate formulated with Adjuvant System 03 (AS03) was shown to be safe and effective and was therefore selected for vaccine development and clinical trials.
References: PMID: 34983950 / doi: 10.1038/s41423-021-00809-2
Contact Info: Brian Ward: [email protected]
URL: https://www.nature.com/articles/s41423-021-00809-2
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Ology Bioservices; Harvard Medical School, Vanderbilt University Medical Center; US Department of Defense; Logistics Management Institute; Washington University School of Medicine; Bioqual, Inc.
Keywords: SARS-CoV-2, neutralizing human monoclonal antibodies, primates
Summary of Study: Neutralizing antibodies with extended half-life and lacking Fc-mediated effector functions are efficient for pre-exposure prophylaxis of SARS-CoV-2 infection in NHPs.
References: PMID: 35132398 / doi: 10.1016/j.medj.2022.01.004
Contact Info: Dan Barouch: [email protected]
URL: https://www.cell.com/med/fulltext/S2666-6340(22)00039-3?_returnURL=https%3A//li…
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Ology Bioservices; Harvard Medical School, Vanderbilt University Medical Center; US Department of Defense; Logistics Management Institute; Washington University School of Medicine; Bioqual, Inc.
Keywords: SARS-CoV-2, neutralizing human monoclonal antibodies, primates
Summary of Study: Neutralizing antibodies with extended half-life and lacking Fc-mediated effector functions are efficient for pre-exposure prophylaxis of SARS-CoV-2 infection in NHPs.
References: PMID: 35132398 / doi: 10.1016/j.medj.2022.01.004
Contact Info: Dan Barouch: [email protected]
URL: https://www.cell.com/med/fulltext/S2666-6340(22)00039-3?_returnURL=https%3A//li…