Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Research Institute for Biological Safety Problems, Kazakhstan
Keywords: SARS-CoV-2, inactivated vaccine, safety, immune response, several animal species, primates
Summary of Study: The first COVID-19 inactivated vaccine developed in Kazakhstan did not result in any adverse effect or change in condition of the animals' health, has high immunogenic potential, and is safe to move to clinical research.
References: PMID: 35960911 / doi: 10.1080/21645515.2022.2087412
Contact Info: Zhandos Abay: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/21645515.2022.2087412
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Research Institute for Biological Safety Problems, Kazakhstan
Keywords: SARS-CoV-2, inactivated vaccine, safety, immune response, several animal species, primates
Summary of Study: The first COVID-19 inactivated vaccine developed in Kazakhstan did not result in any adverse effect or change in condition of the animals' health, has high immunogenic potential, and is safe to move to clinical research.
References: PMID: 35960911 / doi: 10.1080/21645515.2022.2087412
Contact Info: Zhandos Abay: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/21645515.2022.2087412
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Université Paris-Saclay; Université de Paris; Laboratoire de Pharmacocinétique et Toxicologie; Institut Pasteur; Centre International de Recherche en Infectiologie; Unité des Virus Emergents, Aix Marseille Univ; VirNext, Université Claude Bernard Lyon 1; University Hospital, Bordeaux & Inserm
Keywords: SARS-CoV-2, Zika, favipiravir, antiviral activity, primates
Summary of Study: A nucleoside analogue with activity against RNA viruses shows antiviral activity that reduces viral load and kinetics in Zika, but not COVID-19.
References: PMID: 36042198 / doi: 10.1038/s41467-022-32565-w
Contact Info: Roger Le Grand: [email protected]; Jeremie Guedj: [email protected]
URL: https://www.nature.com/articles/s41467-022-32565-w
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Université Paris-Saclay; Université de Paris; Laboratoire de Pharmacocinétique et Toxicologie; Institut Pasteur; Centre International de Recherche en Infectiologie; Unité des Virus Emergents, Aix Marseille Univ; VirNext, Université Claude Bernard Lyon 1; University Hospital, Bordeaux & Inserm
Keywords: SARS-CoV-2, Zika, favipiravir, antiviral activity, primates
Summary of Study: A nucleoside analogue with activity against RNA viruses shows antiviral activity that reduces viral load and kinetics in Zika, but not COVID-19.
References: PMID: 36042198 / doi: 10.1038/s41467-022-32565-w
Contact Info: Roger Le Grand: [email protected]; Jeremie Guedj: [email protected]
URL: https://www.nature.com/articles/s41467-022-32565-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Meissa Vaccines Inc; Bill & Melinda Gates Foundation; BIOQUAL Inc; Butler University; Vanderbilt University School of Medicine; University of Texas Medical Branch
Keywords: SARS-CoV-2, attenuated recombinant vaccine, immune response, primates
Summary of Study: A live, attenuated, recombinant human respiratory virus that expresses a chimeric SARS-CoV-2 spike protected against challenge and induced immunoglobulin and neutralizing antibodies.
References: PMID: 35906244 / doi: 10.1038/s41541-022-00509-6
Contact Info: Mariana F. Tioni: [email protected]
URL: https://www.nature.com/articles/s41541-022-00509-6
NHP Species: marmosets
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Meissa Vaccines Inc; Bill & Melinda Gates Foundation; BIOQUAL Inc; Butler University; Vanderbilt University School of Medicine; University of Texas Medical Branch
Keywords: SARS-CoV-2, attenuated recombinant vaccine, immune response, primates
Summary of Study: A live, attenuated, recombinant human respiratory virus that expresses a chimeric SARS-CoV-2 spike protected against challenge and induced immunoglobulin and neutralizing antibodies.
References: PMID: 35906244 / doi: 10.1038/s41541-022-00509-6
Contact Info: Mariana F. Tioni: [email protected]
URL: https://www.nature.com/articles/s41541-022-00509-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences & Peking Union Medical College; Kunming No.1 High School; Kunming National High-level Biosafety Primate Research Center
Keywords: SARS-CoV-2, vaccines, repertoire diversities of B cells and T cells, whole-virus inactivated and S1 protein subunit vaccine, primates
Summary of Study: Comparison of B-cell and T-cell responses between a whole-virus inactivated vaccine and an S1 protein subunit vaccine.
References: PMID: 36070519 / doi: 10.1080/21645515.2022.2118477
Contact Info: Huiwen Zheng: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/21645515.2022.2118477
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences & Peking Union Medical College; Kunming No.1 High School; Kunming National High-level Biosafety Primate Research Center
Keywords: SARS-CoV-2, vaccines, repertoire diversities of B cells and T cells, whole-virus inactivated and S1 protein subunit vaccine, primates
Summary of Study: Comparison of B-cell and T-cell responses between a whole-virus inactivated vaccine and an S1 protein subunit vaccine.
References: PMID: 36070519 / doi: 10.1080/21645515.2022.2118477
Contact Info: Huiwen Zheng: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/21645515.2022.2118477
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Veterinary and Animal Sciences, Pakistan
Keywords: SARS-CoV-2, iodine complexes, treatment, primates
Summary of Study: Iodine complexes have antiviral activity and help to clear coronavirus from monkeys, and Renessans with iodine complexes and ascorbic acid may provide an additive option for treatment.
References: PMID: 36143459; doi: 10.3390/life12091424
Contact Info: Tahir Yaqub: [email protected]
URL: https://www.mdpi.com/2075-1729/12/9/1424
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Veterinary and Animal Sciences, Pakistan
Keywords: SARS-CoV-2, iodine complexes, treatment, primates
Summary of Study: Iodine complexes have antiviral activity and help to clear coronavirus from monkeys, and Renessans with iodine complexes and ascorbic acid may provide an additive option for treatment.
References: PMID: 36143459; doi: 10.3390/life12091424
Contact Info: Tahir Yaqub: [email protected]
URL: https://www.mdpi.com/2075-1729/12/9/1424
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Center for Genetic Engineering and Biotechnology; Civilian Defense Scienti?c Research Center, Carretera de Jamaica y Autopista Nacional; Biotechnology and Pharmaceutical Industries Group, BioCubaFarma, Ave; Latin American School of Medicine
Keywords: SARS-CoV-2, vaccine, yeast, manufacturing, mice, primates
Summary of Study: The COVID-19 receptor-binding domain produced in yeast cells can be modified by adding amino acids in order to create a possible vaccine candidate due to its ability to stimulate anti-inflammatory cells and inhibit binding to ACE2.
References: PMID: 35953030 / doi: 10.1016/j.nbt.2022.08.002
Contact Info: Gerardo Guillén-Nieto: Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Ave. 31 E/ 158 y 190, La Habana 10600, Cuba
URL: https://www.sciencedirect.com/science/article/pii/S1871678422000462?via%3Dihub=
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Center for Genetic Engineering and Biotechnology; Civilian Defense Scienti?c Research Center, Carretera de Jamaica y Autopista Nacional; Biotechnology and Pharmaceutical Industries Group, BioCubaFarma, Ave; Latin American School of Medicine
Keywords: SARS-CoV-2, vaccine, yeast, manufacturing, mice, primates
Summary of Study: The COVID-19 receptor-binding domain produced in yeast cells can be modified by adding amino acids in order to create a possible vaccine candidate due to its ability to stimulate anti-inflammatory cells and inhibit binding to ACE2.
References: PMID: 35953030 / doi: 10.1016/j.nbt.2022.08.002
Contact Info: Gerardo Guillén-Nieto: Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Ave. 31 E/ 158 y 190, La Habana 10600, Cuba
URL: https://www.sciencedirect.com/science/article/pii/S1871678422000462?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Institutes for Food and Drug Control, Beijing; Guangzhou Laboratory; Kunming National High-level Biosafety Primate Research Center
Keywords: SARS-CoV-2, vaccine, chimpanzee adenovirus vector, immune response, mice, primates
Summary of Study: Using a chimpanzee adenovirus vectored vaccine expressing SARS-CoV2 spike in combination with an inactivated vaccine reduced lung injury risk while maintaining flexibility of the antibody regulation system.
References: PMID: 36059554 / doi: 10.3389/fimmu.2022.949248
Contact Info: Junzhi Wang: [email protected]; Zhenglun Liang: [email protected]; Miao Xu: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.949248/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Institutes for Food and Drug Control, Beijing; Guangzhou Laboratory; Kunming National High-level Biosafety Primate Research Center
Keywords: SARS-CoV-2, vaccine, chimpanzee adenovirus vector, immune response, mice, primates
Summary of Study: Using a chimpanzee adenovirus vectored vaccine expressing SARS-CoV2 spike in combination with an inactivated vaccine reduced lung injury risk while maintaining flexibility of the antibody regulation system.
References: PMID: 36059554 / doi: 10.3389/fimmu.2022.949248
Contact Info: Junzhi Wang: [email protected]; Zhenglun Liang: [email protected]; Miao Xu: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.949248/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shanghai East Hospital, Tongji University School of Medicine; Renji Hospital, Shanghai Jiao Tong University School of Medicine; National Kunming High-level Biosafety Primate Research Center; Naval Medical University; China Pharmaceutical University
Keywords: SARS-CoV-2, vaccine, single-cell transcriptome, immune response, primates
Summary of Study: A lipopolyplex-based mRNA vaccine provides a strong immune response by inhibiting the recruitment of proinflammatory macrophages and by providing lung protecting through inhibiting the apoptotic processes in long epithelial and endothelial cells.
References: PMID: 36124363 / doi: 10.1002/jmv.28161
Contact Info: Ang Lin: [email protected]; Zhenzhen Zhan: [email protected]; Xingguang Liu: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/jmv.28161
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shanghai East Hospital, Tongji University School of Medicine; Renji Hospital, Shanghai Jiao Tong University School of Medicine; National Kunming High-level Biosafety Primate Research Center; Naval Medical University; China Pharmaceutical University
Keywords: SARS-CoV-2, vaccine, single-cell transcriptome, immune response, primates
Summary of Study: A lipopolyplex-based mRNA vaccine provides a strong immune response by inhibiting the recruitment of proinflammatory macrophages and by providing lung protecting through inhibiting the apoptotic processes in long epithelial and endothelial cells.
References: PMID: 36124363 / doi: 10.1002/jmv.28161
Contact Info: Ang Lin: [email protected]; Zhenzhen Zhan: [email protected]; Xingguang Liu: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/jmv.28161
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; AstraZeneca; Vanderbilt University Medical Center; Ragon Institute of MGH, MIT, and Harvard, Cambridge
Keywords: SARS-CoV-2, vaccine, bivalent monoclonal antibody, immune response, primates
Summary of Study: Using human monoclonal antibodies that target the spike glycoprotein can be administered along with viral vector-based SARS-CoV-2 vaccines without losing any effectiveness of either product.
References: PMID: 35857623 / doi: 10.1126/scitranslmed.abo6160
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abo6160?rfr_dat=cr_pub%20…
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; AstraZeneca; Vanderbilt University Medical Center; Ragon Institute of MGH, MIT, and Harvard, Cambridge
Keywords: SARS-CoV-2, vaccine, bivalent monoclonal antibody, immune response, primates
Summary of Study: Using human monoclonal antibodies that target the spike glycoprotein can be administered along with viral vector-based SARS-CoV-2 vaccines without losing any effectiveness of either product.
References: PMID: 35857623 / doi: 10.1126/scitranslmed.abo6160
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abo6160?rfr_dat=cr_pub%20…
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Research Centre for Epidemiology and Microbiology; Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences; Sechenov First Moscow State Medical University
Keywords: SARS-CoV-2, vector-based heterologous vaccine, immune response, mice, primates
Summary of Study: Intranasal Sputnik V vaccine is a novel mucosal vaccine with immunogenic and protective properties identified by immunoglobin and neutralizing antibody production, antigen-specific T-cell response, and cytokine release.
References: PMID: 36031930 / doi: 10.1080/22221751.2022.2119169
Contact Info: Amir I. Tukhvatulin: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2119169
NHP Species: marmosets
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Research Centre for Epidemiology and Microbiology; Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences; Sechenov First Moscow State Medical University
Keywords: SARS-CoV-2, vector-based heterologous vaccine, immune response, mice, primates
Summary of Study: Intranasal Sputnik V vaccine is a novel mucosal vaccine with immunogenic and protective properties identified by immunoglobin and neutralizing antibody production, antigen-specific T-cell response, and cytokine release.
References: PMID: 36031930 / doi: 10.1080/22221751.2022.2119169
Contact Info: Amir I. Tukhvatulin: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2119169
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chulalongkorn University, Bangkok, Thailand; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathum Thani, Thailand; Baiya Phytopharm Co., Ltd., Bangkok, Thailand; Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand; National Primate Research Center of Thailand-Chulalongkorn University, Saraburi, Thailand.
Keywords: SARS-CoV-2, recombinant subunit vaccine, plants, immune response, mice, primates
Summary of Study: Three-dose regimen of Baiya SARS-CoV-2 Vax 1 vaccine elicits neutralizing immune response against SARS-CoV-2 variants.
References: doi: 10.3389/fpls.2022.901978
Contact Info: Waranyoo Phoolcharoen: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fpls.2022.901978/full
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chulalongkorn University, Bangkok, Thailand; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathum Thani, Thailand; Baiya Phytopharm Co., Ltd., Bangkok, Thailand; Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand; National Primate Research Center of Thailand-Chulalongkorn University, Saraburi, Thailand.
Keywords: SARS-CoV-2, recombinant subunit vaccine, plants, immune response, mice, primates
Summary of Study: Three-dose regimen of Baiya SARS-CoV-2 Vax 1 vaccine elicits neutralizing immune response against SARS-CoV-2 variants.
References: doi: 10.3389/fpls.2022.901978
Contact Info: Waranyoo Phoolcharoen: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fpls.2022.901978/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Ragon Institute of MGH, MIT, and Harvard; University of Massachusetts; Bioqual
Keywords: SARS-CoV-2, adenovirus vector–based vaccine Ad26.COV2.S, immune response, primates
Summary of Study: Cytotoxic T-cells that are vaccine induced contribute to virus control, and when depleted, higher viral loads are seen in the respiratory tract.
References: PMID: 35943359 / doi: 10.1126/sciimmunol.abq7647
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/full/10.1126/sciimmunol.abq7647?rfr_dat=cr_pub%20%2…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Ragon Institute of MGH, MIT, and Harvard; University of Massachusetts; Bioqual
Keywords: SARS-CoV-2, adenovirus vector–based vaccine Ad26.COV2.S, immune response, primates
Summary of Study: Cytotoxic T-cells that are vaccine induced contribute to virus control, and when depleted, higher viral loads are seen in the respiratory tract.
References: PMID: 35943359 / doi: 10.1126/sciimmunol.abq7647
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/full/10.1126/sciimmunol.abq7647?rfr_dat=cr_pub%20%2…
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Milan, Milan, Italy
Keywords: SARS-CoV-2, review, natural and experimental infection, several animal species, primates
Summary of Study: Review updating information on natural and experimental SARS-CoV-2 infections in animals.
References: doi: 10.1007/s00705-022-05609-1
Contact Info: Lauretta Turin: [email protected]
URL: https://link.springer.com/article/10.1007/s00705-022-05609-1
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Milan, Milan, Italy
Keywords: SARS-CoV-2, review, natural and experimental infection, several animal species, primates
Summary of Study: Review updating information on natural and experimental SARS-CoV-2 infections in animals.
References: doi: 10.1007/s00705-022-05609-1
Contact Info: Lauretta Turin: [email protected]
URL: https://link.springer.com/article/10.1007/s00705-022-05609-1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Ology Bioservices; Harvard Medical School, Vanderbilt University Medical Center; US Department of Defense; Logistics Management Institute; Washington University School of Medicine; Bioqual, Inc.
Keywords: SARS-CoV-2, neutralizing human monoclonal antibodies, primates
Summary of Study: Neutralizing antibodies with extended half-life and lacking Fc-mediated effector functions are efficient for pre-exposure prophylaxis of SARS-CoV-2 infection in NHPs.
References: PMID: 35132398 / doi: 10.1016/j.medj.2022.01.004
Contact Info: Dan Barouch: [email protected]
URL: https://www.cell.com/med/fulltext/S2666-6340(22)00039-3?_returnURL=https%3A//li…
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Ology Bioservices; Harvard Medical School, Vanderbilt University Medical Center; US Department of Defense; Logistics Management Institute; Washington University School of Medicine; Bioqual, Inc.
Keywords: SARS-CoV-2, neutralizing human monoclonal antibodies, primates
Summary of Study: Neutralizing antibodies with extended half-life and lacking Fc-mediated effector functions are efficient for pre-exposure prophylaxis of SARS-CoV-2 infection in NHPs.
References: PMID: 35132398 / doi: 10.1016/j.medj.2022.01.004
Contact Info: Dan Barouch: [email protected]
URL: https://www.cell.com/med/fulltext/S2666-6340(22)00039-3?_returnURL=https%3A//li…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beijing Institute of Microbiology and Epidemiology; Sinocelltech, Ltd.; Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, polysaccharide–protein-conjugated nanoparticle vaccine, virus variants, mice, rats, primates
Summary of Study: A novel nanoparticle vaccine was designed and prepared by chemically conjugating recombinant SARD-CoV-2 RBD and PPS14. Studies have demonstrated that SCTV01B vaccination induced potent and broad neutralizing antibodies and cellular immune responses against SARS-CoV-2 in mice, rats, and nonhuman primates, as well as high OPA against S. pneumoniae serotype 14.
References: PMID: 35332581 / doi: 10.1002/adma.202200443
Contact Info: Liangzhi Xie: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/adma.202200443
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beijing Institute of Microbiology and Epidemiology; Sinocelltech, Ltd.; Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, polysaccharide–protein-conjugated nanoparticle vaccine, virus variants, mice, rats, primates
Summary of Study: A novel nanoparticle vaccine was designed and prepared by chemically conjugating recombinant SARD-CoV-2 RBD and PPS14. Studies have demonstrated that SCTV01B vaccination induced potent and broad neutralizing antibodies and cellular immune responses against SARS-CoV-2 in mice, rats, and nonhuman primates, as well as high OPA against S. pneumoniae serotype 14.
References: PMID: 35332581 / doi: 10.1002/adma.202200443
Contact Info: Liangzhi Xie: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/adma.202200443
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Institute of Biological Products; Chinese Academy of Medicine Sciences & Peking Union Medical College
Keywords: SARS-CoV-2, recombinant protein subunit vaccine and an inactivated vaccine, virus variants, primates
Summary of Study: Both vaccines evaluated in this study significantly reduced the viral load in the respiratory tract, alleviated pathological changes, and relieved lung inflammation in vaccinated macaques. The possible contribution of antibodies possessing neutralizing reactivity or cell-mediated cytotoxicity and immune memory to vaccine induced protection was also highlighted.
References: PMID: 35241645 / doi: 10.1038/s41392-022-00926-y
Contact Info: Junzhi Wang: [email protected]
URL: https://www.nature.com/articles/s41392-022-00926-y
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Institute of Biological Products; Chinese Academy of Medicine Sciences & Peking Union Medical College
Keywords: SARS-CoV-2, recombinant protein subunit vaccine and an inactivated vaccine, virus variants, primates
Summary of Study: Both vaccines evaluated in this study significantly reduced the viral load in the respiratory tract, alleviated pathological changes, and relieved lung inflammation in vaccinated macaques. The possible contribution of antibodies possessing neutralizing reactivity or cell-mediated cytotoxicity and immune memory to vaccine induced protection was also highlighted.
References: PMID: 35241645 / doi: 10.1038/s41392-022-00926-y
Contact Info: Junzhi Wang: [email protected]
URL: https://www.nature.com/articles/s41392-022-00926-y
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Vaxxiniy, Inc., Dallas, Texas; United Biomedical, Inc. (Taiwan and USA); Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX, USA; others.
Keywords: SARS-CoV-2, subunit protein-peptide vaccine, immunogenicity, rat, mice, primates
Summary of Study: RBD-Protein/Peptide Vaccine Elicits Broadly Neutralizing Antibodies
References: doi: 10.1080/22221751.2022.2140608
Contact Info: Farshad Guirakhoo: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2140608
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Vaxxiniy, Inc., Dallas, Texas; United Biomedical, Inc. (Taiwan and USA); Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX, USA; others.
Keywords: SARS-CoV-2, subunit protein-peptide vaccine, immunogenicity, rat, mice, primates
Summary of Study: RBD-Protein/Peptide Vaccine Elicits Broadly Neutralizing Antibodies
References: doi: 10.1080/22221751.2022.2140608
Contact Info: Farshad Guirakhoo: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2140608
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; Yerkes National Primate Research Center; Emory University School of Medicine; Bioqual; Moderna, Inc.
Keywords: SARS-CoV-2, mRNA-1273 vaccination, longitudinal study, immune response, primates
Summary of Study: While mRNA-1273 provided durable protection against B.1.617.2 challenge, control of the virus was briefly delayed in the lungs and limited in the nose, which may provide the virus with a greater opportunity for transmission.
References: PMID: 34921774 / doi: 10.1016/j.cell.2021.12.002
Contact Info: Robert Seder: [email protected]; Daniel Douek: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0092867421014057?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; Yerkes National Primate Research Center; Emory University School of Medicine; Bioqual; Moderna, Inc.
Keywords: SARS-CoV-2, mRNA-1273 vaccination, longitudinal study, immune response, primates
Summary of Study: While mRNA-1273 provided durable protection against B.1.617.2 challenge, control of the virus was briefly delayed in the lungs and limited in the nose, which may provide the virus with a greater opportunity for transmission.
References: PMID: 34921774 / doi: 10.1016/j.cell.2021.12.002
Contact Info: Robert Seder: [email protected]; Daniel Douek: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0092867421014057?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Elicio Therapeutics; New Iberia Research Center, Louisiana
Keywords: SARS-CoV-2, vaccine, amphiphile adjuvant, immune response, mice, primates
Summary of Study: Lymph-node adjuvant-targeting to coordinate innate immunity and generate robust adaptive responses critical for vaccine efficacy.
References: doi: 10.1038/s41541-022-00560-3
Contact Info: Peter DeMuth: [email protected]
URL: https://www.nature.com/articles/s41541-022-00560-3
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Elicio Therapeutics; New Iberia Research Center, Louisiana
Keywords: SARS-CoV-2, vaccine, amphiphile adjuvant, immune response, mice, primates
Summary of Study: Lymph-node adjuvant-targeting to coordinate innate immunity and generate robust adaptive responses critical for vaccine efficacy.
References: doi: 10.1038/s41541-022-00560-3
Contact Info: Peter DeMuth: [email protected]
URL: https://www.nature.com/articles/s41541-022-00560-3
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital; National Kunming High-level Biosafety Primate Research Center; Nagasaki University; Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, self-assembled trimeric protein vaccine, virus variants, mice, primates
Summary of Study: A self-assembled trimeric protein made from linking a sequence from the Delta variant and a subunit in SARS-CoV-2 shows a strong immune response against Omicron variants.
References: PMID: 36115859 / doi: 10.1038/s41467-022-33209-9
Contact Info: Xiangrong Song: [email protected]; Shuaiyao Lu: [email protected]; Xiaozhong Peng: [email protected]; Guangwen Lu: [email protected]; Xiawei Wei: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482656/
NHP Species: multiple species
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital; National Kunming High-level Biosafety Primate Research Center; Nagasaki University; Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, self-assembled trimeric protein vaccine, virus variants, mice, primates
Summary of Study: A self-assembled trimeric protein made from linking a sequence from the Delta variant and a subunit in SARS-CoV-2 shows a strong immune response against Omicron variants.
References: PMID: 36115859 / doi: 10.1038/s41467-022-33209-9
Contact Info: Xiangrong Song: [email protected]; Shuaiyao Lu: [email protected]; Xiaozhong Peng: [email protected]; Guangwen Lu: [email protected]; Xiawei Wei: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482656/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; CureVac AG, Tübingen, Germany
Keywords: SARS-CoV-2, unmodified mRNA vaccine, CVnCoV, immune response, primates
Summary of Study: A third dose of the unmodified COVID-19 mRNA vaccine CVnCoV enhances quality and quantity of immune responses.
References: doi: 10.1016/j.omtm.2022.10.001
Contact Info: Karin Loré: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2329050122001437?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; CureVac AG, Tübingen, Germany
Keywords: SARS-CoV-2, unmodified mRNA vaccine, CVnCoV, immune response, primates
Summary of Study: A third dose of the unmodified COVID-19 mRNA vaccine CVnCoV enhances quality and quantity of immune responses.
References: doi: 10.1016/j.omtm.2022.10.001
Contact Info: Karin Loré: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2329050122001437?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre (BPRC), Rijswijk, Netherlands; Department of Radiology and Nuclear Medicine, Tracer Center Amsterdam (TCA), Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands
Keywords: SARS-CoV-2, PET-CT imaging, lungs, inflammation, primates
Summary of Study: Vaccine candidate involving a valuable radiotracer to visualize SARS-CoV-2-associated pulmonary inflammation
References: PMID: 35660200 PMCID: PMC9148436 DOI: 10.1016/j.nucmedbio.2022.05.002
Contact Info: Marieke A Stammes: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0969805122020509?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre (BPRC), Rijswijk, Netherlands; Department of Radiology and Nuclear Medicine, Tracer Center Amsterdam (TCA), Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands
Keywords: SARS-CoV-2, PET-CT imaging, lungs, inflammation, primates
Summary of Study: Vaccine candidate involving a valuable radiotracer to visualize SARS-CoV-2-associated pulmonary inflammation
References: PMID: 35660200 PMCID: PMC9148436 DOI: 10.1016/j.nucmedbio.2022.05.002
Contact Info: Marieke A Stammes: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0969805122020509?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane University, Memorial Sloan Kettering Cancer Ctr, Weill Cornell Medical College, Instuto de Química Pontificia Universidad Católica de Valparaíso
Keywords: SARS-CoV-2, urokinase plasminogen activator receptor, renal dysfunction, pathology, primates
Summary of Study: Elevated soluble urokinase plasminogen activator receptor
References: doi: 10.1111/jmp.12626
Contact Info: Minolfa Prieto: [email protected]
URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/jmp.12626
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane University, Memorial Sloan Kettering Cancer Ctr, Weill Cornell Medical College, Instuto de Química Pontificia Universidad Católica de Valparaíso
Keywords: SARS-CoV-2, urokinase plasminogen activator receptor, renal dysfunction, pathology, primates
Summary of Study: Elevated soluble urokinase plasminogen activator receptor
References: doi: 10.1111/jmp.12626
Contact Info: Minolfa Prieto: [email protected]
URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/jmp.12626
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: Gujarat Biotechnology Research Centre (GBRC), India; Kamdhenu University, Gujarat, India; University of California Santa Barbara, Santa Barbara, CA.
Keywords: SARS-CoV-2, surveillance, RT-PCR, several animal species, primates
Summary of Study: Highlights transmission of SARS-CoV-2 infection from human to animals and suggests being watchful for zoonosis.
References: doi: 10.3390/ijerph192114391
Contact Info: Arunkumar Patel: [email protected]
URL: https://www.mdpi.com/1660-4601/19/21/14391
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: Gujarat Biotechnology Research Centre (GBRC), India; Kamdhenu University, Gujarat, India; University of California Santa Barbara, Santa Barbara, CA.
Keywords: SARS-CoV-2, surveillance, RT-PCR, several animal species, primates
Summary of Study: Highlights transmission of SARS-CoV-2 infection from human to animals and suggests being watchful for zoonosis.
References: doi: 10.3390/ijerph192114391
Contact Info: Arunkumar Patel: [email protected]
URL: https://www.mdpi.com/1660-4601/19/21/14391
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Saskatchewan; Dalhousie University; University of Pittsburgh
Keywords: SARS-CoV-2, review, post-acute sequelae, pathology, immune response, several animal species, primates
Summary of Study: Analysis of work done in different animal models in order to understand the mechanisms of Long COVID that could help identify treatments.
References: PMID: 36070309 / doi: 10.1371/journal.ppat.1010741
Contact Info: Alyson A. Kelvin: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010741
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Saskatchewan; Dalhousie University; University of Pittsburgh
Keywords: SARS-CoV-2, review, post-acute sequelae, pathology, immune response, several animal species, primates
Summary of Study: Analysis of work done in different animal models in order to understand the mechanisms of Long COVID that could help identify treatments.
References: PMID: 36070309 / doi: 10.1371/journal.ppat.1010741
Contact Info: Alyson A. Kelvin: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010741
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences & Peking Union Medical College; Kunming No.1 High School; Kunming National High-level Biosafety Primate Research Center
Keywords: SARS-CoV-2, vaccines, repertoire diversities of B cells and T cells, whole-virus inactivated and S1 protein subunit vaccine, primates
Summary of Study: Comparison of B-cell and T-cell responses between a whole-virus inactivated vaccine and an S1 protein subunit vaccine.
References: PMID: 36070519 / doi: 10.1080/21645515.2022.2118477
Contact Info: Huiwen Zheng: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/21645515.2022.2118477
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences & Peking Union Medical College; Kunming No.1 High School; Kunming National High-level Biosafety Primate Research Center
Keywords: SARS-CoV-2, vaccines, repertoire diversities of B cells and T cells, whole-virus inactivated and S1 protein subunit vaccine, primates
Summary of Study: Comparison of B-cell and T-cell responses between a whole-virus inactivated vaccine and an S1 protein subunit vaccine.
References: PMID: 36070519 / doi: 10.1080/21645515.2022.2118477
Contact Info: Huiwen Zheng: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/21645515.2022.2118477
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Veterinary and Animal Sciences, Pakistan
Keywords: SARS-CoV-2, iodine complexes, treatment, primates
Summary of Study: Iodine complexes have antiviral activity and help to clear coronavirus from monkeys, and Renessans with iodine complexes and ascorbic acid may provide an additive option for treatment.
References: PMID: 36143459; doi: 10.3390/life12091424
Contact Info: Tahir Yaqub: [email protected]
URL: https://www.mdpi.com/2075-1729/12/9/1424
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Veterinary and Animal Sciences, Pakistan
Keywords: SARS-CoV-2, iodine complexes, treatment, primates
Summary of Study: Iodine complexes have antiviral activity and help to clear coronavirus from monkeys, and Renessans with iodine complexes and ascorbic acid may provide an additive option for treatment.
References: PMID: 36143459; doi: 10.3390/life12091424
Contact Info: Tahir Yaqub: [email protected]
URL: https://www.mdpi.com/2075-1729/12/9/1424
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA; numerous others
Keywords: SARS-CoV-2, vaccine, Ad26.COV2.S, spike ferritin nanoparticles, immune response, primates
Summary of Study: Protection against SARS-CoV-2 Omicron BA.1 variant challenge
References: doi: 10.1126/sciadv.ade4433
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.ade4433
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA; numerous others
Keywords: SARS-CoV-2, vaccine, Ad26.COV2.S, spike ferritin nanoparticles, immune response, primates
Summary of Study: Protection against SARS-CoV-2 Omicron BA.1 variant challenge
References: doi: 10.1126/sciadv.ade4433
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.ade4433
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Peking University; Chinese Academy of Medical Sciences and Peking Union Medical College; WHO Collaborating Center for Standardization and Evaluation of Biologicals
Keywords: SARS-CoV-2, circRNA vaccine, neutralizing antibodies, virus variants, primates
Summary of Study: CircRNA/RBD-Omicron vaccine induced effective neutralizing antibodies against the Omicron but not the Delta variant. In contrast, the circRNA/RBD-Delta vaccine protected against both Delta and Omicron or functioned as a booster after two doses of either native- or Delta-specific vaccination, making it a favorable choice against the current variants of concern of SARS-CoV-2.
References: PMID: 35460644 / doi: 10.1016/j.cell.2022.03.044
Contact Info: Wensheng Wei: [email protected]
URL: https://www.cell.com/cell/fulltext/S0092-8674(22)00394-4?_returnURL=https%3A//l…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Peking University; Chinese Academy of Medical Sciences and Peking Union Medical College; WHO Collaborating Center for Standardization and Evaluation of Biologicals
Keywords: SARS-CoV-2, circRNA vaccine, neutralizing antibodies, virus variants, primates
Summary of Study: CircRNA/RBD-Omicron vaccine induced effective neutralizing antibodies against the Omicron but not the Delta variant. In contrast, the circRNA/RBD-Delta vaccine protected against both Delta and Omicron or functioned as a booster after two doses of either native- or Delta-specific vaccination, making it a favorable choice against the current variants of concern of SARS-CoV-2.
References: PMID: 35460644 / doi: 10.1016/j.cell.2022.03.044
Contact Info: Wensheng Wei: [email protected]
URL: https://www.cell.com/cell/fulltext/S0092-8674(22)00394-4?_returnURL=https%3A//l…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Shiga University of Medical Science, Otsu, Japan; others
Keywords: SARS-CoV-2, vaccine development, attenuated vaccinia virus, immune response, proteomics, virus variants, mice, primates
Summary of Study: Vaccine protects monkeys and transgenic mice from SARS-CoV-2 and variants
References: doi: 10.3389/fmicb.2022.967019
Contact Info: Michinori Kohara: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2022.967019/full
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Shiga University of Medical Science, Otsu, Japan; others
Keywords: SARS-CoV-2, vaccine development, attenuated vaccinia virus, immune response, proteomics, virus variants, mice, primates
Summary of Study: Vaccine protects monkeys and transgenic mice from SARS-CoV-2 and variants
References: doi: 10.3389/fmicb.2022.967019
Contact Info: Michinori Kohara: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2022.967019/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chin Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, China
Keywords: SARS-CoV-2, review, traditional Chinese medicine, mice, hamsters, primates
Summary of Study: Model exploration for discovering COVID-19 targeted traditional Chinese medicine
References: doi: 10.1016/j.heliyon.2022.e12333
Contact Info: Fengmei Lian: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2405844022036210?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chin Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, China
Keywords: SARS-CoV-2, review, traditional Chinese medicine, mice, hamsters, primates
Summary of Study: Model exploration for discovering COVID-19 targeted traditional Chinese medicine
References: doi: 10.1016/j.heliyon.2022.e12333
Contact Info: Fengmei Lian: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2405844022036210?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Wuhan Institute of Virology; Chinese Academy of Science; Wuhan National Biosafety Library, others
Keywords: SARS-CoV-2, testicular pathological damage, inflammation, primates
Summary of Study: SARS-CoV-2 infection induces testicular injury in Rhesus macaque
References: 10.1016/j.virs.2022.10.008
Contact Info: Z. Wuan: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1995820X22001833?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Wuhan Institute of Virology; Chinese Academy of Science; Wuhan National Biosafety Library, others
Keywords: SARS-CoV-2, testicular pathological damage, inflammation, primates
Summary of Study: SARS-CoV-2 infection induces testicular injury in Rhesus macaque
References: 10.1016/j.virs.2022.10.008
Contact Info: Z. Wuan: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1995820X22001833?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine
Keywords: SARS-CoV-2, virus genome, gut, virus evolution, primates
Summary of Study: Previous reports that an intact furin cleavage site is important for infection in vivo were confirmed in this study. Additionally, three mutations were identified that may represent an adaptation of SARS-CoV2 to African green monkeys or to NHP generally.
References: PMID: 35062281 / doi: 10.3390/v14010077
Contact Info: Nicholas Maness: [email protected]
URL: https://www.mdpi.com/1999-4915/14/1/77
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine
Keywords: SARS-CoV-2, virus genome, gut, virus evolution, primates
Summary of Study: Previous reports that an intact furin cleavage site is important for infection in vivo were confirmed in this study. Additionally, three mutations were identified that may represent an adaptation of SARS-CoV2 to African green monkeys or to NHP generally.
References: PMID: 35062281 / doi: 10.3390/v14010077
Contact Info: Nicholas Maness: [email protected]
URL: https://www.mdpi.com/1999-4915/14/1/77
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shanghai Zerun Biotech Co., Ltd.; numerous others
Keywords: SARS-CoV-2, recombinant vaccine, immunogenicity, virus variants, hamster, primates
Summary of Study: A potent, broadly protective vaccine against SARS-CoV-2 variants of concern.
References: doi: 10.1038/s41541-022-00571-0
Contact Info: Chenliang Zhou: [email protected]
URL: https://www.nature.com/articles/s41541-022-00571-0
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shanghai Zerun Biotech Co., Ltd.; numerous others
Keywords: SARS-CoV-2, recombinant vaccine, immunogenicity, virus variants, hamster, primates
Summary of Study: A potent, broadly protective vaccine against SARS-CoV-2 variants of concern.
References: doi: 10.1038/s41541-022-00571-0
Contact Info: Chenliang Zhou: [email protected]
URL: https://www.nature.com/articles/s41541-022-00571-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; University of California, Irvine
Keywords: SARS-CoV-2, Vesicular Stomatitis Virus-Based Vaccine, route of administration, immune response, primates
Summary of Study: The VSV-SARS2-EBOV vaccine presents a vaccine with a high potential as a boosting option after the already-approved mRNA-based vaccine, because VSV-SARS2-EBOV elicits primarily a humoral response, in contrast to the predominantly T cell-driven immune response after mRNA vaccination.
References: PMID: 35012339 / doi: 10.1128/mbio.03379-21
Contact Info: Andrea Marzi: [email protected]
URL: https://journals.asm.org/doi/full/10.1128/mbio.03379-21?rfr_dat=cr_pub%20%200pu…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; University of California, Irvine
Keywords: SARS-CoV-2, Vesicular Stomatitis Virus-Based Vaccine, route of administration, immune response, primates
Summary of Study: The VSV-SARS2-EBOV vaccine presents a vaccine with a high potential as a boosting option after the already-approved mRNA-based vaccine, because VSV-SARS2-EBOV elicits primarily a humoral response, in contrast to the predominantly T cell-driven immune response after mRNA vaccination.
References: PMID: 35012339 / doi: 10.1128/mbio.03379-21
Contact Info: Andrea Marzi: [email protected]
URL: https://journals.asm.org/doi/full/10.1128/mbio.03379-21?rfr_dat=cr_pub%20%200pu…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID RNA Viruses Section, Laboratory of Infectious Diseases, numerous others
Keywords: SARS-CoV-2, pediatric vaccine, live-attenuated parainfluenza-virus-vectored vaccine, immunogenicity, primates
Summary of Study: Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine is protective in monkeys
References: doi: 10.1016/j.cell.2022.11.006
Contact Info: Ursula Buchholz: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0092867422014180?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID RNA Viruses Section, Laboratory of Infectious Diseases, numerous others
Keywords: SARS-CoV-2, pediatric vaccine, live-attenuated parainfluenza-virus-vectored vaccine, immunogenicity, primates
Summary of Study: Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine is protective in monkeys
References: doi: 10.1016/j.cell.2022.11.006
Contact Info: Ursula Buchholz: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0092867422014180?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: China Pharmaceutical University; Yunnan Walvax Biotech
Keywords: SARS-CoV-2, chimpanzee adenovirus-based vaccine, immunogenicity, toxicology, rats, primates
Summary of Study: AdC68-19S, a recombinant chimpanzee adenovirus serotype 68 vector-based vaccine encoding the full-length spike protein of SARS-CoV-2, induced an effective immune response with a good safety profile in rhesus macaques.
References: PMID: 35226134 / doi: 10.1007/s00204-021-03221-x
Contact Info: Zhen Huang: [email protected]
URL: https://link.springer.com/article/10.1007/s00204-021-03221-x
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: China Pharmaceutical University; Yunnan Walvax Biotech
Keywords: SARS-CoV-2, chimpanzee adenovirus-based vaccine, immunogenicity, toxicology, rats, primates
Summary of Study: AdC68-19S, a recombinant chimpanzee adenovirus serotype 68 vector-based vaccine encoding the full-length spike protein of SARS-CoV-2, induced an effective immune response with a good safety profile in rhesus macaques.
References: PMID: 35226134 / doi: 10.1007/s00204-021-03221-x
Contact Info: Zhen Huang: [email protected]
URL: https://link.springer.com/article/10.1007/s00204-021-03221-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID Laboratory of Virology and NIAID Rocky Mountain Veterinary Branch, Hamilton, MT
Keywords: SARS-CoV-2, pathology, virus variants, primates
Summary of Study: Omicron BA.1 and BA.2 are attenuated in rhesus macaques as compared to Delta
References: doi: 10.1126/sciadv.ade1860
Contact Info: Kyle Rosenke: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.ade1860
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID Laboratory of Virology and NIAID Rocky Mountain Veterinary Branch, Hamilton, MT
Keywords: SARS-CoV-2, pathology, virus variants, primates
Summary of Study: Omicron BA.1 and BA.2 are attenuated in rhesus macaques as compared to Delta
References: doi: 10.1126/sciadv.ade1860
Contact Info: Kyle Rosenke: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.ade1860
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Massachusetts Institute of Technology; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University; Scripps Research Institute; University of Louisiana at Lafayette; Beth Israel Deaconess Medical Center, Harvard Medical School; Howard Hughes Medical Institute
Keywords: SARS-CoV-2, lipid-conjugated immunogen, intranasal vaccination, mice, primates
Summary of Study: To combat the problem of poor vaccine uptake across mucus and epithelial linings, intranasal immunization with amphilic albumin binding components was created with the ability to be delivered across the mucosal epithelium and generate an antigen-specific response.
References: PMID: 35857825 / doi: 10.1126/scitranslmed.abn1413
Contact Info: Darrell Irvine: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abn1413?url_ver=Z39.88-2003&rf…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Massachusetts Institute of Technology; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University; Scripps Research Institute; University of Louisiana at Lafayette; Beth Israel Deaconess Medical Center, Harvard Medical School; Howard Hughes Medical Institute
Keywords: SARS-CoV-2, lipid-conjugated immunogen, intranasal vaccination, mice, primates
Summary of Study: To combat the problem of poor vaccine uptake across mucus and epithelial linings, intranasal immunization with amphilic albumin binding components was created with the ability to be delivered across the mucosal epithelium and generate an antigen-specific response.
References: PMID: 35857825 / doi: 10.1126/scitranslmed.abn1413
Contact Info: Darrell Irvine: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abn1413?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences & Peking Union Medical College; National Institute for Viral Disease Control and Prevention
Keywords: SARS-CoV-2, inactivated vaccine, pathology, virus variants, primates
Summary of Study: Three doses of a prototypic SARS-CoV-2 inactivated vaccine reduced viral loads in nasal, throat and anal swabs and pulmonary tissues and improved the pathological changes lungs of animals infected by variants of Alpha, Beta and Delta.
References: PMID: 35217639 / doi: 10.1038/s41392-022-00920-4
Contact Info: Zhongping Xie: [email protected]; Wenjie Tan: [email protected]
URL: https://www.nature.com/articles/s41392-022-00920-4
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences & Peking Union Medical College; National Institute for Viral Disease Control and Prevention
Keywords: SARS-CoV-2, inactivated vaccine, pathology, virus variants, primates
Summary of Study: Three doses of a prototypic SARS-CoV-2 inactivated vaccine reduced viral loads in nasal, throat and anal swabs and pulmonary tissues and improved the pathological changes lungs of animals infected by variants of Alpha, Beta and Delta.
References: PMID: 35217639 / doi: 10.1038/s41392-022-00920-4
Contact Info: Zhongping Xie: [email protected]; Wenjie Tan: [email protected]
URL: https://www.nature.com/articles/s41392-022-00920-4
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Paris-East Creteil University; Universite Paris-Saclay Fontenay-aux-Roses; CEA-INSERM, University of Lille; Universite de Lyon; Centre de Recherche en Cancerologie de Lyon; Institut Curie; Justus Liebig University
Keywords: SARS-CoV-2, lung cell senescence, RNA analysis, pathology, humans, primates
Summary of Study: Cell senescence was monitored in cynomolgus macaques to evaluate potential links between SARS-CoV-2 infection and aging. Data constitute the first evidence of temporal and topographic relations between senescent cell accumulation and pulmonary lesions induced by SARS-CoV-2.
References: PMID: 34648725 / doi: 10.1165/rcmb.2021-0205LE
Contact Info: Serge Adnot: [email protected]
URL: https://www.atsjournals.org/doi/10.1165/rcmb.2021-0205LE?url_ver=Z39.88-2003&rf…
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Paris-East Creteil University; Universite Paris-Saclay Fontenay-aux-Roses; CEA-INSERM, University of Lille; Universite de Lyon; Centre de Recherche en Cancerologie de Lyon; Institut Curie; Justus Liebig University
Keywords: SARS-CoV-2, lung cell senescence, RNA analysis, pathology, humans, primates
Summary of Study: Cell senescence was monitored in cynomolgus macaques to evaluate potential links between SARS-CoV-2 infection and aging. Data constitute the first evidence of temporal and topographic relations between senescent cell accumulation and pulmonary lesions induced by SARS-CoV-2.
References: PMID: 34648725 / doi: 10.1165/rcmb.2021-0205LE
Contact Info: Serge Adnot: [email protected]
URL: https://www.atsjournals.org/doi/10.1165/rcmb.2021-0205LE?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; University of California, San Diego; University of Cape Town, Observatory, South Africa
Keywords: SARS-CoV-2, mild infection, pathology, immune response, primates
Summary of Study: SARS-CoV-2 replication wanes in the lungs, as well as the nasal and oral mucosa, of rhesus macaques before antigen-specific effector T cells arrive at those sites, suggesting that innate immunity efficiently restricts viral replication during mild COVID-19.
References: PMID: 35271298 / doi: 10.1126/sciimmunol.abo0535
Contact Info: Daniel Barber: [email protected]
URL: https://www.science.org/doi/full/10.1126/sciimmunol.abo0535?rfr_dat=cr_pub%20%2…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; University of California, San Diego; University of Cape Town, Observatory, South Africa
Keywords: SARS-CoV-2, mild infection, pathology, immune response, primates
Summary of Study: SARS-CoV-2 replication wanes in the lungs, as well as the nasal and oral mucosa, of rhesus macaques before antigen-specific effector T cells arrive at those sites, suggesting that innate immunity efficiently restricts viral replication during mild COVID-19.
References: PMID: 35271298 / doi: 10.1126/sciimmunol.abo0535
Contact Info: Daniel Barber: [email protected]
URL: https://www.science.org/doi/full/10.1126/sciimmunol.abo0535?rfr_dat=cr_pub%20%2…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Beijing Institute for Brain Disorders, Capital Medical University, China; State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing , numerous others.
Keywords: SARS-CoV-2, single-nucleus transcriptomics, pathology, immune response, primates
Summary of Study: Single-nucleus transcriptomic profiling of multiple organs
References: doi: 10.24272/j.issn.2095-8137.2022.443
Contact Info: Xiaoqun Wang: nc.ude.unb@gnawnuqoaix
URL: https://www.zoores.ac.cn/en/article/doi/10.24272/j.issn.2095-8137.2022.443
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Beijing Institute for Brain Disorders, Capital Medical University, China; State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing , numerous others.
Keywords: SARS-CoV-2, single-nucleus transcriptomics, pathology, immune response, primates
Summary of Study: Single-nucleus transcriptomic profiling of multiple organs
References: doi: 10.24272/j.issn.2095-8137.2022.443
Contact Info: Xiaoqun Wang: nc.ude.unb@gnawnuqoaix
URL: https://www.zoores.ac.cn/en/article/doi/10.24272/j.issn.2095-8137.2022.443
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Zhongshan School of Medicine; Qianyang Biomedical Research Institute; Guangdong Provincial Center for Disease Control and Prevention
Keywords: SARS-CoV-2, bivalent vaccine, D614G/B.1.351, vaccine dosage, mice, primates
Summary of Study: With a prime-boost or single-dose strategy a bivalent D614G/B.1.351 RBD nanoparticle vaccine elicited robust nAbs and full protection against infection with the authentic D614 or B.1.351 strains in human ACE2 transgene mice. Furthermore, 8 months after inoculation with the D614G-specific vaccine, a new boost with this bivalent vaccine potently elicited cross-nAbs for SARS-CoV-2 variants in rhesus macaques.
References: PMID: 34990583 / doi: 10.1016/j.celrep.2021.110256
Contact Info: Yiwen Zhang: [email protected]; Hui Zhang: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S221112472101768X?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Zhongshan School of Medicine; Qianyang Biomedical Research Institute; Guangdong Provincial Center for Disease Control and Prevention
Keywords: SARS-CoV-2, bivalent vaccine, D614G/B.1.351, vaccine dosage, mice, primates
Summary of Study: With a prime-boost or single-dose strategy a bivalent D614G/B.1.351 RBD nanoparticle vaccine elicited robust nAbs and full protection against infection with the authentic D614 or B.1.351 strains in human ACE2 transgene mice. Furthermore, 8 months after inoculation with the D614G-specific vaccine, a new boost with this bivalent vaccine potently elicited cross-nAbs for SARS-CoV-2 variants in rhesus macaques.
References: PMID: 34990583 / doi: 10.1016/j.celrep.2021.110256
Contact Info: Yiwen Zhang: [email protected]; Hui Zhang: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S221112472101768X?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: MIT; Scripps Research Institute; La Jolla Institute for Immunology; Ragon Institute of Massachusetts General Hospital, MIT, and Harvard University; University of California, San Diego; Yerkes National Primate Research Center; Emory University School of Medicine; MIT
Keywords: SARS-CoV-2, saponin/TLR agonist, vaccine adjuvant, immune response, primates
Summary of Study: Compared with a panel of tested adjuvants including other saponin-based formulations, saponin/MPLA nanoparticles (SMNP) induced superior antibody and germinal center responses after immunization with a poorly immunogenic HIV antigen in both mice and rhesus macaques, suggesting that SMNP may be a promising adjuvant in the setting of HIV, SARS-CoV-2, and other pathogens.
References: PMID: 34860581 / doi: 10.1126/sciimmunol.abf1152
Contact Info: Darrell J. Irvine: [email protected]; Shane Crotty: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.abf1152?url_ver=Z39.88-2003&rfr_…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: MIT; Scripps Research Institute; La Jolla Institute for Immunology; Ragon Institute of Massachusetts General Hospital, MIT, and Harvard University; University of California, San Diego; Yerkes National Primate Research Center; Emory University School of Medicine; MIT
Keywords: SARS-CoV-2, saponin/TLR agonist, vaccine adjuvant, immune response, primates
Summary of Study: Compared with a panel of tested adjuvants including other saponin-based formulations, saponin/MPLA nanoparticles (SMNP) induced superior antibody and germinal center responses after immunization with a poorly immunogenic HIV antigen in both mice and rhesus macaques, suggesting that SMNP may be a promising adjuvant in the setting of HIV, SARS-CoV-2, and other pathogens.
References: PMID: 34860581 / doi: 10.1126/sciimmunol.abf1152
Contact Info: Darrell J. Irvine: [email protected]; Shane Crotty: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.abf1152?url_ver=Z39.88-2003&rfr_…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Universite Paris-Saclay, Inserm, CEA; University of Amsterdam; Grousbeck Gene Therapy Center; Harvard Medical School; The Broad Institute of Harvard and MIT; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, computed X-ray tomography and [18F]-FDG positron emission tomography, pathology, primates
Summary of Study: CT, combined with [18F]-FDG PET imaging, to study SARS-CoV-2 infected NHPs, can produce strong and transposable readouts to monitor COVID-19 disease as well as the efficacy of future treatments and vaccine candidates.
References: PMID: 35313622 / doi: 10.1016/j.isci.2022.104101
Contact Info: Thibaut Naninck: [email protected]
URL: https://www.cell.com/iscience/fulltext/S2589-0042(22)00371-6?_returnURL=https%3…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Universite Paris-Saclay, Inserm, CEA; University of Amsterdam; Grousbeck Gene Therapy Center; Harvard Medical School; The Broad Institute of Harvard and MIT; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, computed X-ray tomography and [18F]-FDG positron emission tomography, pathology, primates
Summary of Study: CT, combined with [18F]-FDG PET imaging, to study SARS-CoV-2 infected NHPs, can produce strong and transposable readouts to monitor COVID-19 disease as well as the efficacy of future treatments and vaccine candidates.
References: PMID: 35313622 / doi: 10.1016/j.isci.2022.104101
Contact Info: Thibaut Naninck: [email protected]
URL: https://www.cell.com/iscience/fulltext/S2589-0042(22)00371-6?_returnURL=https%3…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center, Texas Biomedical Research Institute; Washington University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, longitudinal scRNAseq, bronchoalveolar lavage, immune response, primates
Summary of Study: Results unequivocally show that in protected, immunocompetent hosts, SARS-CoV-2 infection is characterized by an acute inflammatory response leading to a myeloid cell influx into the lung compartment. Induction of a robust IFN response in macrophages strongly correlates with viremia and subsequent clearance of SARS-CoV-2 from the airways of macaques.
References: PMID: 35115549 / doi: 10.1038/s41467-022-28315-7
Contact Info: Maxim Artyomov: [email protected]
URL: https://www.nature.com/articles/s41467-022-28315-7
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center, Texas Biomedical Research Institute; Washington University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, longitudinal scRNAseq, bronchoalveolar lavage, immune response, primates
Summary of Study: Results unequivocally show that in protected, immunocompetent hosts, SARS-CoV-2 infection is characterized by an acute inflammatory response leading to a myeloid cell influx into the lung compartment. Induction of a robust IFN response in macrophages strongly correlates with viremia and subsequent clearance of SARS-CoV-2 from the airways of macaques.
References: PMID: 35115549 / doi: 10.1038/s41467-022-28315-7
Contact Info: Maxim Artyomov: [email protected]
URL: https://www.nature.com/articles/s41467-022-28315-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Universite Paris-Saclay, INSERM, CEA; Life and Soft; IRCCS Ospedale San Raffaele; Institut Pasteur
Keywords: SARS-CoV-2, neonate animals, immune response, pathology, primates
Summary of Study: This pilot study demonstrates that neonatal NHPs are a relevant model for pediatric SARS-CoV-2 infection.
References: PMID: 35603150 / doi: 10.3389/fimmu.2022.855230
Contact Info: Nabila Seddiki: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.855230/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Universite Paris-Saclay, INSERM, CEA; Life and Soft; IRCCS Ospedale San Raffaele; Institut Pasteur
Keywords: SARS-CoV-2, neonate animals, immune response, pathology, primates
Summary of Study: This pilot study demonstrates that neonatal NHPs are a relevant model for pediatric SARS-CoV-2 infection.
References: PMID: 35603150 / doi: 10.3389/fimmu.2022.855230
Contact Info: Nabila Seddiki: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.855230/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; Tongji Medical College of Huazhong University of Science & Technology
Keywords: SARS-CoV-2, infection, pathogenesis, virus variants, primates
Summary of Study: Delta variant of SARS-CoV-2 can effectively infect the Rhesus macaque.
References: PMID: 35279412 / doi: 10.1016/j.virs.2022.02.001
Contact Info: Zhiming Yuan: [email protected]; Chao Shan: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1995820X22000335?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; Tongji Medical College of Huazhong University of Science & Technology
Keywords: SARS-CoV-2, infection, pathogenesis, virus variants, primates
Summary of Study: Delta variant of SARS-CoV-2 can effectively infect the Rhesus macaque.
References: PMID: 35279412 / doi: 10.1016/j.virs.2022.02.001
Contact Info: Zhiming Yuan: [email protected]; Chao Shan: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1995820X22000335?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Bordeaux; Université Paris-Saclay; Vaccine Research Institute Créteil; Inserm U955 Créteil; Baylor Scott and White Research Institute; Institut Pasteur Paris; CNRS UMR 3569; University of Amsterdam Amsterdam Infection & Immunity Institute Amsterdam; Hôpital Henri-Mondor Albert-Chenevier; CHU Bordeaux
Keywords: SARS-CoV-2, mathematical modelling, vaccine, viral dynamics, primates
Summary of Study: A model-based approach can identify mechanistic correlates of protection that vaccines provide against infection, such that inhibition of the receptor-binding domain to ACE2 represents a strong mechanism of protection.
References: PMID: 35801637 / doi: 10.7554/eLife.75427
Contact Info: Rodolphe Thiébaut: [email protected]
URL: https://elifesciences.org/articles/75427
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Bordeaux; Université Paris-Saclay; Vaccine Research Institute Créteil; Inserm U955 Créteil; Baylor Scott and White Research Institute; Institut Pasteur Paris; CNRS UMR 3569; University of Amsterdam Amsterdam Infection & Immunity Institute Amsterdam; Hôpital Henri-Mondor Albert-Chenevier; CHU Bordeaux
Keywords: SARS-CoV-2, mathematical modelling, vaccine, viral dynamics, primates
Summary of Study: A model-based approach can identify mechanistic correlates of protection that vaccines provide against infection, such that inhibition of the receptor-binding domain to ACE2 represents a strong mechanism of protection.
References: PMID: 35801637 / doi: 10.7554/eLife.75427
Contact Info: Rodolphe Thiébaut: [email protected]
URL: https://elifesciences.org/articles/75427