Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Emory University; University of Sao Paulo School of Medicine; Butantan Institute; La Jolla Institute for Immunology
Keywords: SARS-CoV-2, DNA vaccine HIVBr18, HLA class II vaccine epitopes, immunity, humans and primates
Summary of Study: Results provide preliminary proof of concept that immunization with a vaccine encoding epitopes with high and redundant coverage of the human population can elicit potent T cell responses to multiple epitopes, across species and MHC barriers.
References: PMID: 34961636 / doi: 10.1016/j.vaccine.2021.11.076
Contact Info: Edecio Cunha-Neto: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21015504?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Emory University; University of Sao Paulo School of Medicine; Butantan Institute; La Jolla Institute for Immunology
Keywords: SARS-CoV-2, DNA vaccine HIVBr18, HLA class II vaccine epitopes, immunity, humans and primates
Summary of Study: Results provide preliminary proof of concept that immunization with a vaccine encoding epitopes with high and redundant coverage of the human population can elicit potent T cell responses to multiple epitopes, across species and MHC barriers.
References: PMID: 34961636 / doi: 10.1016/j.vaccine.2021.11.076
Contact Info: Edecio Cunha-Neto: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21015504?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; Yerkes National Primate Research Center; Emory University School of Medicine; Bioqual; Moderna, Inc.
Keywords: SARS-CoV-2, mRNA-1273 vaccination, longitudinal study, immune response, primates
Summary of Study: While mRNA-1273 provided durable protection against B.1.617.2 challenge, control of the virus was briefly delayed in the lungs and limited in the nose, which may provide the virus with a greater opportunity for transmission.
References: PMID: 34921774 / doi: 10.1016/j.cell.2021.12.002
Contact Info: Robert Seder: [email protected]; Daniel Douek: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0092867421014057?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; Yerkes National Primate Research Center; Emory University School of Medicine; Bioqual; Moderna, Inc.
Keywords: SARS-CoV-2, mRNA-1273 vaccination, longitudinal study, immune response, primates
Summary of Study: While mRNA-1273 provided durable protection against B.1.617.2 challenge, control of the virus was briefly delayed in the lungs and limited in the nose, which may provide the virus with a greater opportunity for transmission.
References: PMID: 34921774 / doi: 10.1016/j.cell.2021.12.002
Contact Info: Robert Seder: [email protected]; Daniel Douek: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0092867421014057?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shanghai Medical College, Fudan University; Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College; the First Affiliated Hospital of Guangzhou Medical University; Guangzhou Eighth People's Hospital of Guangzhou Medical University; Bio-Island; Graduate School of Peking Union Medical College; NIFDC; Fulgent Pharma LLC
Keywords: SARS-CoV-2, pan-sarbecovirus vaccines, STING agonist CF501, virus variants, immune response, mice, rabbits, primates.
Summary of Study: A pan-sarbecovirus vaccine was designed by using human IgG Fc-conjugated RBD from the original SARS-CoV-2 strain as the vaccine's immunogen and the STING agonist CF501 as the vaccine's adjuvant. This CF501/RBD-Fc vaccine candidate was able to induce extremely potent, durable, and broad-spectrum nAb and T cell responses, as well as protective immunity, suggesting its potential for development as a highly potent and durable pan-sarbecovirus vaccine.
References: PMID: 35046518 / doi: 10.1038/s41422-022-00612-2
Contact Info: Youchun Wang: [email protected]; Yilong Zhang: [email protected]; Jincun Zhao: [email protected]
URL: https://www.nature.com/articles/s41422-022-00612-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shanghai Medical College, Fudan University; Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College; the First Affiliated Hospital of Guangzhou Medical University; Guangzhou Eighth People's Hospital of Guangzhou Medical University; Bio-Island; Graduate School of Peking Union Medical College; NIFDC; Fulgent Pharma LLC
Keywords: SARS-CoV-2, pan-sarbecovirus vaccines, STING agonist CF501, virus variants, immune response, mice, rabbits, primates.
Summary of Study: A pan-sarbecovirus vaccine was designed by using human IgG Fc-conjugated RBD from the original SARS-CoV-2 strain as the vaccine's immunogen and the STING agonist CF501 as the vaccine's adjuvant. This CF501/RBD-Fc vaccine candidate was able to induce extremely potent, durable, and broad-spectrum nAb and T cell responses, as well as protective immunity, suggesting its potential for development as a highly potent and durable pan-sarbecovirus vaccine.
References: PMID: 35046518 / doi: 10.1038/s41422-022-00612-2
Contact Info: Youchun Wang: [email protected]; Yilong Zhang: [email protected]; Jincun Zhao: [email protected]
URL: https://www.nature.com/articles/s41422-022-00612-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: prevention
NPRC/Institute: AstraZeneca; BIOQUAL; Vanderbilt University; USAMRIID
Keywords: SARS-CoV-2, monoclonal antibody combination, AZD7442,virus protection, humans, primates
Summary of Study: AZD7442, a monoclonal antibody comprised of AZD8895 and AZD1061, demonstrated potent in vitro neutralization against SARS-CoV-2 VOCs, in vivo efficacy in both prevention and treatment settings of SARS-CoV-2 infection in NHPs, and extended half-life in NHPs and healthy adult participants.
References: PMID: 35076282 / doi: 10.1126/scitranslmed.abl8124
Contact Info: Mark Esser: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abl8124?url_ver=Z39.88-2003&rf…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: prevention
NPRC/Institute: AstraZeneca; BIOQUAL; Vanderbilt University; USAMRIID
Keywords: SARS-CoV-2, monoclonal antibody combination, AZD7442,virus protection, humans, primates
Summary of Study: AZD7442, a monoclonal antibody comprised of AZD8895 and AZD1061, demonstrated potent in vitro neutralization against SARS-CoV-2 VOCs, in vivo efficacy in both prevention and treatment settings of SARS-CoV-2 infection in NHPs, and extended half-life in NHPs and healthy adult participants.
References: PMID: 35076282 / doi: 10.1126/scitranslmed.abl8124
Contact Info: Mark Esser: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abl8124?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; University of Oxford
Keywords: SARS-CoV-2, age-specific immune responses, viral load, primates
Summary of Study: Despite similar disease outcomes, multiomics profiling suggests that age may delay or impair antiviral cellular immune responses and delay efficient return to homeostasis.
References: PMID: 35039442 / doi: 10.26508/lsa.202101314
Contact Info: Emmie de Wit: [email protected]
URL: https://www.life-science-alliance.org/content/5/4/e202101314
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; University of Oxford
Keywords: SARS-CoV-2, age-specific immune responses, viral load, primates
Summary of Study: Despite similar disease outcomes, multiomics profiling suggests that age may delay or impair antiviral cellular immune responses and delay efficient return to homeostasis.
References: PMID: 35039442 / doi: 10.26508/lsa.202101314
Contact Info: Emmie de Wit: [email protected]
URL: https://www.life-science-alliance.org/content/5/4/e202101314
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medicine Sciences & Peking Union Medical College; National Institute for Viral Disease Control and Prevention
Keywords: SARS-CoV-2, heterologous vaccines, intradermal administration, immune response, primates
Summary of Study: This study reports a new heterologous prime-boost strategy of intradermal immunization with the inactivated vaccine and K-S antigen. This strategy can significantly increase the neutralizing antibody titers and promote specific T cell responses in mice and macaques.
References: PMID: 34931939 / doi: 10.1080/22221751.2021807https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
Contact Info: Wenbo Xu: [email protected]; Qihan Li: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medicine Sciences & Peking Union Medical College; National Institute for Viral Disease Control and Prevention
Keywords: SARS-CoV-2, heterologous vaccines, intradermal administration, immune response, primates
Summary of Study: This study reports a new heterologous prime-boost strategy of intradermal immunization with the inactivated vaccine and K-S antigen. This strategy can significantly increase the neutralizing antibody titers and promote specific T cell responses in mice and macaques.
References: PMID: 34931939 / doi: 10.1080/22221751.2021807https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
Contact Info: Wenbo Xu: [email protected]; Qihan Li: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine; Nanchang University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, CRISPR-RT–PCR assay, longitudinal analysis, mucosal, plasma, and breath samples, primates
Summary of Study: CRISPR-FDS may provide a means to evaluate systemic viral/viral RNA burden not detectable by RT-qPCR to improve diagnosis and better predict outcomes for SARS-CoV-2 infections.
References: PMID: 35108153 / doi: 10.1080/22221751.2038020
Contact Info: Tony Hu: tonyhu2tulane.edu
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2038020
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine; Nanchang University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, CRISPR-RT–PCR assay, longitudinal analysis, mucosal, plasma, and breath samples, primates
Summary of Study: CRISPR-FDS may provide a means to evaluate systemic viral/viral RNA burden not detectable by RT-qPCR to improve diagnosis and better predict outcomes for SARS-CoV-2 infections.
References: PMID: 35108153 / doi: 10.1080/22221751.2038020
Contact Info: Tony Hu: tonyhu2tulane.edu
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2038020
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Ragon Institute of MGH, MIT, and Harvard; Novavax; University of Duisburg-Essen; MIT; Texas Biomedical Research Institute; University of Maryland School of Medicine; Duke University Medical Center; La Jolla Institute for Immunology; and others
Keywords: SARS-CoV-2, humoral immune response, vaccine-induced antibody fingerprint, protection, primates
Summary of Study: Data presented suggest that a single dose may prevent disease via combined Fc/Fab functions but that two doses may be essential to block further transmission of SARS-CoV-2 and emerging variants.
References: PMID: 34485950 / doi: 10.1016/j.xcrm.2021.100405
Contact Info: Gale Smith: [email protected]; Galit Alter: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009701
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Ragon Institute of MGH, MIT, and Harvard; Novavax; University of Duisburg-Essen; MIT; Texas Biomedical Research Institute; University of Maryland School of Medicine; Duke University Medical Center; La Jolla Institute for Immunology; and others
Keywords: SARS-CoV-2, humoral immune response, vaccine-induced antibody fingerprint, protection, primates
Summary of Study: Data presented suggest that a single dose may prevent disease via combined Fc/Fab functions but that two doses may be essential to block further transmission of SARS-CoV-2 and emerging variants.
References: PMID: 34485950 / doi: 10.1016/j.xcrm.2021.100405
Contact Info: Gale Smith: [email protected]; Galit Alter: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009701
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: SW National Primate Research Center, Washington University School of Medicine, Texas Biomedical Research Institute, Tulane University
Keywords: SARS-CoV-2, single-cell RNA sequencing. Immune response, primates
Summary of Study: The recruitment of a myeloid-cell-mediated Type I IFN response is associated with the rapid clearance of SARS-CoV-2 infection in macaques.
References: PMID: 34282414 / doi: 10.21203/rs.3.rs-664507/v1
Contact Info: Deepak Kaushal: [email protected]
URL: https://www.researchsquare.com/article/rs-664507/v1
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: SW National Primate Research Center, Washington University School of Medicine, Texas Biomedical Research Institute, Tulane University
Keywords: SARS-CoV-2, single-cell RNA sequencing. Immune response, primates
Summary of Study: The recruitment of a myeloid-cell-mediated Type I IFN response is associated with the rapid clearance of SARS-CoV-2 infection in macaques.
References: PMID: 34282414 / doi: 10.21203/rs.3.rs-664507/v1
Contact Info: Deepak Kaushal: [email protected]
URL: https://www.researchsquare.com/article/rs-664507/v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Akston Biosciences Corp.; Biomere Biomedical Research Models; Feigin ABSL-3 Facility, Baylor College of Medicine; BIOQUAL; California National Primate Research Center; Sinclair Research Center; Pharmaceutical Research Associates Group B.V.
Keywords: SARS-CoV-2, viral spike protein, immunogenicity, prophylaxis, Fc-fusion, mice, primates
Summary of Study: Preclinical studies support the initiation of Phase I clinical studies with adjuvanted AKS-452 with the expectation that this room-temperature stable, Fc-fusion subunit vaccine can be rapidly and inexpensively manufactured to provide billions of doses per year especially in regions where the cold-chain is difficult to maintain.
References: PMID: 34642088 / doi: 10.1016/j.vaccine.2021.09.077
Contact Info: Todd Zion: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21012949?via%3Dihub=
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Akston Biosciences Corp.; Biomere Biomedical Research Models; Feigin ABSL-3 Facility, Baylor College of Medicine; BIOQUAL; California National Primate Research Center; Sinclair Research Center; Pharmaceutical Research Associates Group B.V.
Keywords: SARS-CoV-2, viral spike protein, immunogenicity, prophylaxis, Fc-fusion, mice, primates
Summary of Study: Preclinical studies support the initiation of Phase I clinical studies with adjuvanted AKS-452 with the expectation that this room-temperature stable, Fc-fusion subunit vaccine can be rapidly and inexpensively manufactured to provide billions of doses per year especially in regions where the cold-chain is difficult to maintain.
References: PMID: 34642088 / doi: 10.1016/j.vaccine.2021.09.077
Contact Info: Todd Zion: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21012949?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Pasteur Institute of Iran; Amirabad Virology Laboratory; Tarbiat Modares University; University of Tehran; Islamic Azad University; Hamadan University of Medical Sciences; Darou Pakhsh Pharmaceutical; Arena Diagnostic; and others.
Keywords: SARS-CoV-2, inactivated whole-virus vaccine, safety, immune response, guinea pig, rabbit, mice, primates
Summary of Study: Rhesus macaques were immunised with the two-dose schedule of 5 or 3 ug of the B1V1-CovIran vaccine and showed highly efficient protection against 10^4 TCID50 of SARS-CoV-2 intratracheal challenge compared with the control group.
References: PMID: 34699647 / doi: 10.1002/rmv.2305
Contact Info: Reza Aalizadeh: [email protected]; Hasan Jalili: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/rmv.2305
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Pasteur Institute of Iran; Amirabad Virology Laboratory; Tarbiat Modares University; University of Tehran; Islamic Azad University; Hamadan University of Medical Sciences; Darou Pakhsh Pharmaceutical; Arena Diagnostic; and others.
Keywords: SARS-CoV-2, inactivated whole-virus vaccine, safety, immune response, guinea pig, rabbit, mice, primates
Summary of Study: Rhesus macaques were immunised with the two-dose schedule of 5 or 3 ug of the B1V1-CovIran vaccine and showed highly efficient protection against 10^4 TCID50 of SARS-CoV-2 intratracheal challenge compared with the control group.
References: PMID: 34699647 / doi: 10.1002/rmv.2305
Contact Info: Reza Aalizadeh: [email protected]; Hasan Jalili: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/rmv.2305
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center, Tulane University School of Medicine, Tulane University, Brigham and Women's Hospital/Harvard Medical School, LSU Health Science Center, Julius-Maximilians-Universitat Wurzburg, and more
Keywords: SARS-CoV-2, pulmonary vascular endotheliosis, perivascular inflammation, rodents and primates
Summary of Study: SARS-CoV-2 causes endotheliitis via both infection and infection-mediated immune activation, which may contribute to the pathogenesis of severe COVID-19 disease.
References: PMID: 34335981 / doi: 10.7150/thno.61810
Contact Info: Jay Kolls: [email protected]; Fengming Liu: [email protected]; Jay Rappaport: [email protected]
URL: https://www.thno.org/v11p8076.htm
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center, Tulane University School of Medicine, Tulane University, Brigham and Women's Hospital/Harvard Medical School, LSU Health Science Center, Julius-Maximilians-Universitat Wurzburg, and more
Keywords: SARS-CoV-2, pulmonary vascular endotheliosis, perivascular inflammation, rodents and primates
Summary of Study: SARS-CoV-2 causes endotheliitis via both infection and infection-mediated immune activation, which may contribute to the pathogenesis of severe COVID-19 disease.
References: PMID: 34335981 / doi: 10.7150/thno.61810
Contact Info: Jay Kolls: [email protected]; Fengming Liu: [email protected]; Jay Rappaport: [email protected]
URL: https://www.thno.org/v11p8076.htm
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center, Tulane University School of Medicine, Tulane University, Brigham and Women's Hospital/Harvard Medical School, LSU Health Science Center, Julius-Maximilians-Universitat Wurzburg, and more
Keywords: SARS-CoV-2, endotheliopathy, inflammation, primates, mice
Summary of Study: In addition to pneumocytes, SARS-CoV-2 also directly infects mature vascular endothelial cells in vivo and ex vivo which may contribute to cardiovascular complications in SARS-CoV-2 infection, including multiple organ failure.
References: PMID: 34307198 / doi: 10.3389/fcimb.2021.701278
Contact Info: Xuebin Qin: [email protected]; Suleyman Ergun: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292147/
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center, Tulane University School of Medicine, Tulane University, Brigham and Women's Hospital/Harvard Medical School, LSU Health Science Center, Julius-Maximilians-Universitat Wurzburg, and more
Keywords: SARS-CoV-2, endotheliopathy, inflammation, primates, mice
Summary of Study: In addition to pneumocytes, SARS-CoV-2 also directly infects mature vascular endothelial cells in vivo and ex vivo which may contribute to cardiovascular complications in SARS-CoV-2 infection, including multiple organ failure.
References: PMID: 34307198 / doi: 10.3389/fcimb.2021.701278
Contact Info: Xuebin Qin: [email protected]; Suleyman Ergun: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292147/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences, National Institute of Food and Drug Control (Beijing, China), Yunnan Provincial Infectious Disease Hospital, Yunnan Center for Disease Control and Prevention, Kunming Third People's Hospital
Keywords: SARS-CoV-2, inactivated virus vaccine, immune response, pathology, mice, primates
Summary of Study: Inactivated SARS-CoV-2 vaccine, produced by sequential inactivation with formaldehyde followed by propiolactone, was shown to be effective against SARS-Co-V 2 challenge in rhesus macaques.
References: PMID: 34462721 / doi: 10.1016/j.omtm.2021.08.005
Contact Info: Changgui Li: [email protected]; Qihan Li: [email protected]; Longding Liu: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2329050121001315?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences, National Institute of Food and Drug Control (Beijing, China), Yunnan Provincial Infectious Disease Hospital, Yunnan Center for Disease Control and Prevention, Kunming Third People's Hospital
Keywords: SARS-CoV-2, inactivated virus vaccine, immune response, pathology, mice, primates
Summary of Study: Inactivated SARS-CoV-2 vaccine, produced by sequential inactivation with formaldehyde followed by propiolactone, was shown to be effective against SARS-Co-V 2 challenge in rhesus macaques.
References: PMID: 34462721 / doi: 10.1016/j.omtm.2021.08.005
Contact Info: Changgui Li: [email protected]; Qihan Li: [email protected]; Longding Liu: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2329050121001315?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Yerkes National Primate Research Center, Emory University School of Medicine, Louisiana State University Health Science Center, Texas Children's Center for Vaccine Development, La Jolla Institute for Immunology, and others.
Keywords: SARS-CoV-2, vaccines and adjuvants, immune response, primates
Summary of Study: The adjuvant 3M-052-alum (previously shown to induce better immune responses against HIV) may be a way to improve the efficacy of SARS-CoV-2 vaccines.
References: PMID: 34266981 / doi: 10.1126/sciimmunol.abh3634
Contact Info: Sudhir Pai Kasturi: [email protected]; Maria Elena Bottazzi: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.abh3634?url_ver=Z39.88-2003&rfr_…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Yerkes National Primate Research Center, Emory University School of Medicine, Louisiana State University Health Science Center, Texas Children's Center for Vaccine Development, La Jolla Institute for Immunology, and others.
Keywords: SARS-CoV-2, vaccines and adjuvants, immune response, primates
Summary of Study: The adjuvant 3M-052-alum (previously shown to induce better immune responses against HIV) may be a way to improve the efficacy of SARS-CoV-2 vaccines.
References: PMID: 34266981 / doi: 10.1126/sciimmunol.abh3634
Contact Info: Sudhir Pai Kasturi: [email protected]; Maria Elena Bottazzi: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.abh3634?url_ver=Z39.88-2003&rfr_…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Yerkes National Primate Research Center/Emory University; Emory School of Medicine; Ragon Institute of MGH, MIT and Harvard; The University of Texas Medical Branch; 3M Corporate Research Materials Laboratory; and others.
Keywords: SARS-CoV-2, receptor-binding domain subunit vaccine, neutralizing antibody, immune response, primates
Summary of Study: This study demonstrated the potential benefits of RBD trimer as an immunogen for COVID-19 vaccine using mice and macaque models. Future studies will investigate the durability of the vaccine-induced immune responses and what parameters lead to protection.
References: PMID: 34117252 / doi: 10.1038/s41467-021-23942-y
Contact Info: Rama Rao Amara: [email protected]
URL: https://www.nature.com/articles/s41467-021-23942-y
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Yerkes National Primate Research Center/Emory University; Emory School of Medicine; Ragon Institute of MGH, MIT and Harvard; The University of Texas Medical Branch; 3M Corporate Research Materials Laboratory; and others.
Keywords: SARS-CoV-2, receptor-binding domain subunit vaccine, neutralizing antibody, immune response, primates
Summary of Study: This study demonstrated the potential benefits of RBD trimer as an immunogen for COVID-19 vaccine using mice and macaque models. Future studies will investigate the durability of the vaccine-induced immune responses and what parameters lead to protection.
References: PMID: 34117252 / doi: 10.1038/s41467-021-23942-y
Contact Info: Rama Rao Amara: [email protected]
URL: https://www.nature.com/articles/s41467-021-23942-y
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Qassim University, Buraydah, Saudi Aribia; Imam Abdulrahman Bin Faisal University, MGM Dental College and Hospital, Baba Farid University of Health Sciences, Himachal Institute of Dental Sciences, Panineeya Mahavidyalaya
Keywords: SARS-CoV-2, immune response, animal models, meta analysis, mice, hamsters, ferrets, cats, dogs, primates
Summary of Study: This systematic review found that animal models only mimic limited signs and symptoms experienced in COVID infection as compared to infections in humans, yet are still essential to understand the pathogenesis, transmissibility or viral particles, and vaccine testing.
References: PMID: 34447038 / doi: 10.4103/jpbs.JPBS_749_20
Contact Info: Muhamood Moothedath: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375911/
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Qassim University, Buraydah, Saudi Aribia; Imam Abdulrahman Bin Faisal University, MGM Dental College and Hospital, Baba Farid University of Health Sciences, Himachal Institute of Dental Sciences, Panineeya Mahavidyalaya
Keywords: SARS-CoV-2, immune response, animal models, meta analysis, mice, hamsters, ferrets, cats, dogs, primates
Summary of Study: This systematic review found that animal models only mimic limited signs and symptoms experienced in COVID infection as compared to infections in humans, yet are still essential to understand the pathogenesis, transmissibility or viral particles, and vaccine testing.
References: PMID: 34447038 / doi: 10.4103/jpbs.JPBS_749_20
Contact Info: Muhamood Moothedath: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375911/
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: National Institutes of Biomedical Innovation, Health and Nutrition, Tsukuba, Japan; Osaka University; Gunma University; The University of Tokyo; University of Wisconsin-Madison; Mie University Graduate School of Medicine
Keywords: SARS-CoV-2, pathogenicity, old animals, pathology, immune response, primates
Summary of Study: The COVID-19 cynomolgus monkey model reflects the pathophysiology of humans and would be useful for elucidating the pathophysiology and developing therapeutic agents and vaccines.
References: PMID: 34625475 / doi: 10.1073/pnas.2104847118
Contact Info: Yasuhiro Yasutomi: [email protected]
URL: https://www.pnas.org/content/118/43/e2104847118.long
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: National Institutes of Biomedical Innovation, Health and Nutrition, Tsukuba, Japan; Osaka University; Gunma University; The University of Tokyo; University of Wisconsin-Madison; Mie University Graduate School of Medicine
Keywords: SARS-CoV-2, pathogenicity, old animals, pathology, immune response, primates
Summary of Study: The COVID-19 cynomolgus monkey model reflects the pathophysiology of humans and would be useful for elucidating the pathophysiology and developing therapeutic agents and vaccines.
References: PMID: 34625475 / doi: 10.1073/pnas.2104847118
Contact Info: Yasuhiro Yasutomi: [email protected]
URL: https://www.pnas.org/content/118/43/e2104847118.long
Coronavirus Investigated: SARS-CoV-2
NHP Species: macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Institute for Basic Science (IBS) (Republic of Kores), Eulji University School of Medicine, Seol National University Hospital, Jeonbuk National University Medical School, Sungkyunkwan University School of Medicine
Keywords: SARS-CoV-2, nasal ciliated cells, virus tropism, primates
Summary of Study: Nasal multiciliated epithelial cells are the main target for SARS-CoV-2 infection and replication in the upper airway during the early stages of COVID-19, implying that targeting nasal ciliated cells could be an ideal strategy to prevent SARS-CoV-2 propagation.
References: PMID: 34003804 / doi: 10.1172/JCI148517
Contact Info: Ji Hoon Ahn: [email protected]; JungMo Kim: [email protected]; Seon Pyo Hong: [email protected]; Young Tae Kim: [email protected], Chang-Seop Lee: [email protected]
URL: https://www.jci.org/articles/view/148517
NHP Species: macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Institute for Basic Science (IBS) (Republic of Kores), Eulji University School of Medicine, Seol National University Hospital, Jeonbuk National University Medical School, Sungkyunkwan University School of Medicine
Keywords: SARS-CoV-2, nasal ciliated cells, virus tropism, primates
Summary of Study: Nasal multiciliated epithelial cells are the main target for SARS-CoV-2 infection and replication in the upper airway during the early stages of COVID-19, implying that targeting nasal ciliated cells could be an ideal strategy to prevent SARS-CoV-2 propagation.
References: PMID: 34003804 / doi: 10.1172/JCI148517
Contact Info: Ji Hoon Ahn: [email protected]; JungMo Kim: [email protected]; Seon Pyo Hong: [email protected]; Young Tae Kim: [email protected], Chang-Seop Lee: [email protected]
URL: https://www.jci.org/articles/view/148517
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Universite Paris-Saclay, Inserm; Pereman School of Medicine; Novartis Gene Therapies; Boston University School of Medicine; Institute Pasteur; Mass General Brigham Innovation; Albamunity
Keywords: SARS-CoV-2, AAV-based vaccine, immunogenicity, thermostability, mice, primates
Summary of Study: AAVrh32.33 technology demonstrated its utility as a preventative vaccine for COVID19, and its unique attributes may be applicable to other pathogens or immunization targets.
References: PMID: 34428428 / doi: 10.1016/j.chom.2021.08.002
Contact Info: Luk Vandenberghe: [email protected]; Roger Le Grand: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1931312821003784?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Universite Paris-Saclay, Inserm; Pereman School of Medicine; Novartis Gene Therapies; Boston University School of Medicine; Institute Pasteur; Mass General Brigham Innovation; Albamunity
Keywords: SARS-CoV-2, AAV-based vaccine, immunogenicity, thermostability, mice, primates
Summary of Study: AAVrh32.33 technology demonstrated its utility as a preventative vaccine for COVID19, and its unique attributes may be applicable to other pathogens or immunization targets.
References: PMID: 34428428 / doi: 10.1016/j.chom.2021.08.002
Contact Info: Luk Vandenberghe: [email protected]; Roger Le Grand: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1931312821003784?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: National Health Commission of the People's Republic of China; Chinese Academy of Sciences; Nanjing Medical University; Beijing Institute of Microbiology and Epidemiology; Jiangsu Rec-biotechnology Col Ltd.
Keywords: SARS-CoV-2, neutralizing antibodies, immunization, spike protein, immunogenicity, rabbits, primates
Summary of Study: The immunogenic data derived from immunization with a combination of SARS-CoV-2 RBD and NTD demonstrate the feasibility of eliciting robust targeted immune profiles by using antibody-guided vaccine design.
References: PMID: 34676098 / doi: 10.1093/nsr/nwab053
Contact Info: Xiangxi Wang: [email protected]; Cheng-Feng Qin: [email protected]; Feng-Cai Zhu: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083607/
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: National Health Commission of the People's Republic of China; Chinese Academy of Sciences; Nanjing Medical University; Beijing Institute of Microbiology and Epidemiology; Jiangsu Rec-biotechnology Col Ltd.
Keywords: SARS-CoV-2, neutralizing antibodies, immunization, spike protein, immunogenicity, rabbits, primates
Summary of Study: The immunogenic data derived from immunization with a combination of SARS-CoV-2 RBD and NTD demonstrate the feasibility of eliciting robust targeted immune profiles by using antibody-guided vaccine design.
References: PMID: 34676098 / doi: 10.1093/nsr/nwab053
Contact Info: Xiangxi Wang: [email protected]; Cheng-Feng Qin: [email protected]; Feng-Cai Zhu: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083607/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Universite paris-Saclay/Inserm/Cea; Pereman School of Medicine; Novartis Gene Therapies; Boston University School of Medicine; Ragon Institute of MGH, MIT, and Harvard; and others
Keywords: SARS-CoV-2, AAV-vaccine candidates, immune response, mice, primates
Summary of Study: Studies of the AAV-based vaccine candidate AC1 support its potential to protect from COVID-19 disease and infection from a single-dose immunization; may lead to highly durable immunogenicity; and is stable at ambient temperature for storage for several weeks. The combination of these WHO-specific key attributes have not been met by any of the currently approved vaccines. Continued development of second-generation vaccine candidates such at AC1 is needed.
References: PMID: 34428428 / doi: 10.1016/j.chom.2021.08.002
Contact Info: Roger LeGrand: [email protected]; Luk Vandenberghe: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1931312821003784?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Universite paris-Saclay/Inserm/Cea; Pereman School of Medicine; Novartis Gene Therapies; Boston University School of Medicine; Ragon Institute of MGH, MIT, and Harvard; and others
Keywords: SARS-CoV-2, AAV-vaccine candidates, immune response, mice, primates
Summary of Study: Studies of the AAV-based vaccine candidate AC1 support its potential to protect from COVID-19 disease and infection from a single-dose immunization; may lead to highly durable immunogenicity; and is stable at ambient temperature for storage for several weeks. The combination of these WHO-specific key attributes have not been met by any of the currently approved vaccines. Continued development of second-generation vaccine candidates such at AC1 is needed.
References: PMID: 34428428 / doi: 10.1016/j.chom.2021.08.002
Contact Info: Roger LeGrand: [email protected]; Luk Vandenberghe: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1931312821003784?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences; Shenzhen Kangtai Biotechnology Co., Ltd.; Academy of Military Medical Sciences; Zhenzhou University; National Institutes for Food and Drug Control; Henan Normal University
Keywords: SARS-CoV-2, chimeric spike protein, humoral immune response, pathology, mice, primates
Summary of Study: The strategy of chimerica expression SARS-CoV-2 S RBD in SARS-CoV represents a new design for other vaccine platforms.
References: PMID: 34759261 / doi: 10.1038/s41392-021-00797-9
Contact Info: Shuguang Duo: [email protected]
URL: https://www.nature.com/articles/s41392-021-00797-9
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences; Shenzhen Kangtai Biotechnology Co., Ltd.; Academy of Military Medical Sciences; Zhenzhou University; National Institutes for Food and Drug Control; Henan Normal University
Keywords: SARS-CoV-2, chimeric spike protein, humoral immune response, pathology, mice, primates
Summary of Study: The strategy of chimerica expression SARS-CoV-2 S RBD in SARS-CoV represents a new design for other vaccine platforms.
References: PMID: 34759261 / doi: 10.1038/s41392-021-00797-9
Contact Info: Shuguang Duo: [email protected]
URL: https://www.nature.com/articles/s41392-021-00797-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Tehran, Tabriz University of Medical Sciences, Karolinska Institute, University of Rochester Medical Center, Tokyo University of Science, University of Veterinary Medicine (Vienna)
Keywords: SARS-CoV-2, immune response, reinfection, recovery, primates
Summary of Study: Review paper proposing a new strategy to predict the potential of reinfection in each identified category. This classification may help to distribute resources more meticulously to determine: Who needs to be serologically tested for SARS-CoV-2 neutralizing antibodies, what percentage of the population is immune to the virus, and who needs to be vaccinated.
References: PMID: 33520309 / doi: 10.1016/jare.2020.12.013
Contact Info: Younes Aftabi: [email protected]; Sasan Fereidouni: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2090123220302630?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Tehran, Tabriz University of Medical Sciences, Karolinska Institute, University of Rochester Medical Center, Tokyo University of Science, University of Veterinary Medicine (Vienna)
Keywords: SARS-CoV-2, immune response, reinfection, recovery, primates
Summary of Study: Review paper proposing a new strategy to predict the potential of reinfection in each identified category. This classification may help to distribute resources more meticulously to determine: Who needs to be serologically tested for SARS-CoV-2 neutralizing antibodies, what percentage of the population is immune to the virus, and who needs to be vaccinated.
References: PMID: 33520309 / doi: 10.1016/jare.2020.12.013
Contact Info: Younes Aftabi: [email protected]; Sasan Fereidouni: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2090123220302630?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: California National Primate Research Center, UC Davis School of Medicine, The Rockefeller University, UC Davis School of Veterinary Medicine, DMID/NIAID/NIH, Howard Hughes Medical Institute
Keywords: SARS-CoV-2, therapeutic interventions, neutralizing monoclonal antibodies, pathology, primates
Summary of Study: Study provides proof-of-concept in support of further clinical development of monoclonal antibodies C135-LS and C144-LS against COVID-19 during early infection.
References: PMID: 34228761 / doi: 10.1371/journal.ppat.1009688
Contact Info: Koen Van Rompay: [email protected]; Michel Nussenzweig: [email protected]; J. Rachel Reader: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009688
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: California National Primate Research Center, UC Davis School of Medicine, The Rockefeller University, UC Davis School of Veterinary Medicine, DMID/NIAID/NIH, Howard Hughes Medical Institute
Keywords: SARS-CoV-2, therapeutic interventions, neutralizing monoclonal antibodies, pathology, primates
Summary of Study: Study provides proof-of-concept in support of further clinical development of monoclonal antibodies C135-LS and C144-LS against COVID-19 during early infection.
References: PMID: 34228761 / doi: 10.1371/journal.ppat.1009688
Contact Info: Koen Van Rompay: [email protected]; Michel Nussenzweig: [email protected]; J. Rachel Reader: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009688
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: EcoHealth Alliance; Deakin University; Institute of Epidemiology, Disease Control and Research (Dhaka, Bangladesh); University of Dhaka; Chattogram Veterinary and Animal Sciences University
Keywords: SARS-CoV-2, meta analysis, virus transmission, public health, susceptible animal species, primates
Summary of Study: The continuing spillover and spillback of SARS-CoV-2 in a wide range of animals in farming, captive and free-ranging interfaces make inferences for human and animal health, welfare and conservation. Pets, farmed and captive wild animals should be vaccinated in accordance with vaccination in humans.
References: PMID: 34694705 / doi: 10.111/tbed.14356
Contact Info: Ariful Islam: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1111/tbed.14356
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: EcoHealth Alliance; Deakin University; Institute of Epidemiology, Disease Control and Research (Dhaka, Bangladesh); University of Dhaka; Chattogram Veterinary and Animal Sciences University
Keywords: SARS-CoV-2, meta analysis, virus transmission, public health, susceptible animal species, primates
Summary of Study: The continuing spillover and spillback of SARS-CoV-2 in a wide range of animals in farming, captive and free-ranging interfaces make inferences for human and animal health, welfare and conservation. Pets, farmed and captive wild animals should be vaccinated in accordance with vaccination in humans.
References: PMID: 34694705 / doi: 10.111/tbed.14356
Contact Info: Ariful Islam: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1111/tbed.14356
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Henry M. Jackson Foundation for the Advancement of Military Medicine; Washington University; National Cancer Institute/NIH; BIOQUAL; and others
Keywords: SARS-CoV-2, nanoparticle protein vaccine, humoral and cellular immune responses, primates
Summary of Study: Findings support the continued development of SARS-CoV-2 RBD ferritin nanoparticle vaccines (RFN) for managing COVID-19 and related SARS-CoV-like virus outbreaks.
References: PMID: 34470866 / doi: 10.1073/pnas.2106433118
Contact Info: Kayvon Modjarrad: [email protected]; Diane Bolton: [email protected]
URL: https://www.pnas.org/content/118/38/e2106433118.long
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Henry M. Jackson Foundation for the Advancement of Military Medicine; Washington University; National Cancer Institute/NIH; BIOQUAL; and others
Keywords: SARS-CoV-2, nanoparticle protein vaccine, humoral and cellular immune responses, primates
Summary of Study: Findings support the continued development of SARS-CoV-2 RBD ferritin nanoparticle vaccines (RFN) for managing COVID-19 and related SARS-CoV-like virus outbreaks.
References: PMID: 34470866 / doi: 10.1073/pnas.2106433118
Contact Info: Kayvon Modjarrad: [email protected]; Diane Bolton: [email protected]
URL: https://www.pnas.org/content/118/38/e2106433118.long
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Universite Paris-Saclay/Inserm/CEA; Vaccine Research INstitute, Creteil, France; Inserm; Baylor Scott and White Research Institute; Institut Pasteur; Karolinska Institutet; and others
Keywords: SARS-CoV-2, subunit vaccine, receptor-binding domain, immune response, humanized mice, primates
Summary of Study: A single dose of the alphaCD40.RBD (a vaccine that targets the receptor-binding domain of the SARS-CoV-2 spike antigen to the CD40 receptor) administered without adjuvant boosts the protective response in COVID-10 convalescent NHPs.
References: PMID: 34471122 / doi: 10.1038/s41467-021-25382-0
Contact Info: Yves Levy: [email protected]
URL: https://www.nature.com/articles/s41467-021-25382-0
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Universite Paris-Saclay/Inserm/CEA; Vaccine Research INstitute, Creteil, France; Inserm; Baylor Scott and White Research Institute; Institut Pasteur; Karolinska Institutet; and others
Keywords: SARS-CoV-2, subunit vaccine, receptor-binding domain, immune response, humanized mice, primates
Summary of Study: A single dose of the alphaCD40.RBD (a vaccine that targets the receptor-binding domain of the SARS-CoV-2 spike antigen to the CD40 receptor) administered without adjuvant boosts the protective response in COVID-10 convalescent NHPs.
References: PMID: 34471122 / doi: 10.1038/s41467-021-25382-0
Contact Info: Yves Levy: [email protected]
URL: https://www.nature.com/articles/s41467-021-25382-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Janssen Vaccines & Prevention B.V.; Harvard Medical School; Lucidity Biomedical Consulting; Ragon Institute of MGH, MIT and Harvard; Massachusetts Consortium on Pathogen Readiness
Keywords: SARS-CoV-2, adenovirus vector, immunogenicity, protective efficacy, immune response, primates
Summary of Study: Ad26.COV2.S vaccine confers durable protection against replication of SARS-CoV-2 in the lungs that is predicted by the levels of Spike-binding and neutralizing antibodies, indicating that Ad26.COV2.S could confer durable protection in humans and immunological correlates of protection may enable the prediction of durability of protection.
References: PMID: 34620860 / doi: 10.1038/s41467-021-26117-x
Contact Info: Roland Zahn: [email protected]
URL: https://www.nature.com/articles/s41467-021-26117-x
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Janssen Vaccines & Prevention B.V.; Harvard Medical School; Lucidity Biomedical Consulting; Ragon Institute of MGH, MIT and Harvard; Massachusetts Consortium on Pathogen Readiness
Keywords: SARS-CoV-2, adenovirus vector, immunogenicity, protective efficacy, immune response, primates
Summary of Study: Ad26.COV2.S vaccine confers durable protection against replication of SARS-CoV-2 in the lungs that is predicted by the levels of Spike-binding and neutralizing antibodies, indicating that Ad26.COV2.S could confer durable protection in humans and immunological correlates of protection may enable the prediction of durability of protection.
References: PMID: 34620860 / doi: 10.1038/s41467-021-26117-x
Contact Info: Roland Zahn: [email protected]
URL: https://www.nature.com/articles/s41467-021-26117-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Duke University; UNC Chapel Hill; 3M Corporate Research Materials Laboratory; Infectious Disease Research Institute; California National Primate Research Center; and others
Keywords: SARS-CoV-2, mRNA vaccine, infants, immune response, primates
Summary of Study: Infant rhesus macaques were vaccinated with an mRNA-based SARS-CoV-2 vaccine, similar to the Moderna vaccine, or an S protein plus TLR7/8 agonist-based vaccine. Both vaccines induced profound induction of neutralizing antibody titers, memory B cells responses, and SARS-CV-2 specific CD4+ T cell responses that were long-lasting, all while limiting vaccine related toxicity.
References: PMID: 34131024 / doi: 10.1126/sciimmunol.abj3684
Contact Info: Kristina De Paris: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.abj3684?url_ver=Z39.88-2003&rfr_…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Duke University; UNC Chapel Hill; 3M Corporate Research Materials Laboratory; Infectious Disease Research Institute; California National Primate Research Center; and others
Keywords: SARS-CoV-2, mRNA vaccine, infants, immune response, primates
Summary of Study: Infant rhesus macaques were vaccinated with an mRNA-based SARS-CoV-2 vaccine, similar to the Moderna vaccine, or an S protein plus TLR7/8 agonist-based vaccine. Both vaccines induced profound induction of neutralizing antibody titers, memory B cells responses, and SARS-CV-2 specific CD4+ T cell responses that were long-lasting, all while limiting vaccine related toxicity.
References: PMID: 34131024 / doi: 10.1126/sciimmunol.abj3684
Contact Info: Kristina De Paris: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.abj3684?url_ver=Z39.88-2003&rfr_…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID, Ragon Institute of MGH, MIT< and Harvard, University of Duisburg-Essen, Harvard University, Emory Vaccine Center, Yerkes National Primate Research Center, and others
Keywords: SARS-CoV-2, protein subunit vaccine, soluble prefusion-stabilized spike trimers, immune response, primates
Summary of Study: Soluble prefusion-stablized spike protein trimers (preS DTM) from SARS-CoV-2 were formulated with the adjuvant AS03 and administered twice to NHPs. Two days after challenge, vaccinated NHPs showed rapid control of viral replication in both the upper and lower airways. These data indicate that antibodies induced by the AS03-adjuvanted preS dTM vaccine were sufficient to mediate protection against SARS-CoV-2 in NHPs and that rapid anamnestic antibody responses in the lung may be a key mechanism for protection.
References: PMID: 34315825 / doi: 10.1126/scitranslmed.abi4547
Contact Info: Robert Seder: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abi4547?url_ver=Z39.88-2003&rf…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID, Ragon Institute of MGH, MIT< and Harvard, University of Duisburg-Essen, Harvard University, Emory Vaccine Center, Yerkes National Primate Research Center, and others
Keywords: SARS-CoV-2, protein subunit vaccine, soluble prefusion-stabilized spike trimers, immune response, primates
Summary of Study: Soluble prefusion-stablized spike protein trimers (preS DTM) from SARS-CoV-2 were formulated with the adjuvant AS03 and administered twice to NHPs. Two days after challenge, vaccinated NHPs showed rapid control of viral replication in both the upper and lower airways. These data indicate that antibodies induced by the AS03-adjuvanted preS dTM vaccine were sufficient to mediate protection against SARS-CoV-2 in NHPs and that rapid anamnestic antibody responses in the lung may be a key mechanism for protection.
References: PMID: 34315825 / doi: 10.1126/scitranslmed.abi4547
Contact Info: Robert Seder: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abi4547?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Celltech Pharmed Co.; Iran University of Medical Sciences; University of Iran; Tarbiat Modares University; Royan Institute for Stem Cell Biology and Technology; and others
Keywords: SARS-CoV-2, mRNA-vaccine, lipid nanoparticle, spike protein, immune response, primates
Summary of Study: A novel mRNA-LNP vaccine against SARS-CoV-2 was developed and preclinically evaluated, revealing that it was efficient enough to induce high level production of neutralizing antibodies against SARS-CoV-2 in mice and rhesus macaque monkeys.
References: PMID: 34579244 / doi: 10.3390/vaccines9091007
Contact Info: Alireza Sohi: [email protected]; Jafar Kiani: [email protected]; Ehsan Arefian: [email protected]; Arezou Khosrojerdi: [email protected]; Mohammad Zim: [email protected]
URL: https://www.mdpi.com/2076-393X/9/9/1007
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Celltech Pharmed Co.; Iran University of Medical Sciences; University of Iran; Tarbiat Modares University; Royan Institute for Stem Cell Biology and Technology; and others
Keywords: SARS-CoV-2, mRNA-vaccine, lipid nanoparticle, spike protein, immune response, primates
Summary of Study: A novel mRNA-LNP vaccine against SARS-CoV-2 was developed and preclinically evaluated, revealing that it was efficient enough to induce high level production of neutralizing antibodies against SARS-CoV-2 in mice and rhesus macaque monkeys.
References: PMID: 34579244 / doi: 10.3390/vaccines9091007
Contact Info: Alireza Sohi: [email protected]; Jafar Kiani: [email protected]; Ehsan Arefian: [email protected]; Arezou Khosrojerdi: [email protected]; Mohammad Zim: [email protected]
URL: https://www.mdpi.com/2076-393X/9/9/1007
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Brigham and Women's Hospital and Harvard Medical School, The Affiliated Hospital of Youjiang Medical Univ. for Nationalities (China), and the University of Alabama
Keywords: SARS-CoV-2, ACE2 protein expression, lung injury, mice and primates
Summary of Study: Data from this study unequivocally support the key role of ACE2 in the sinonasal mucosa as a functional reARS-CoV-2; however, the restricted baseline expression pattern of ACE1 in the lung presents a conundrum as it raises questions about alternative viral receptors or additional mechanisms of lung injury in COVID-19 pneumonia.
References: PMID: 33626084 / doi: 10.1371/journal.pone.0247510
Contact Info: Sule Cataltepe: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0247510
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Brigham and Women's Hospital and Harvard Medical School, The Affiliated Hospital of Youjiang Medical Univ. for Nationalities (China), and the University of Alabama
Keywords: SARS-CoV-2, ACE2 protein expression, lung injury, mice and primates
Summary of Study: Data from this study unequivocally support the key role of ACE2 in the sinonasal mucosa as a functional reARS-CoV-2; however, the restricted baseline expression pattern of ACE1 in the lung presents a conundrum as it raises questions about alternative viral receptors or additional mechanisms of lung injury in COVID-19 pneumonia.
References: PMID: 33626084 / doi: 10.1371/journal.pone.0247510
Contact Info: Sule Cataltepe: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0247510
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Karolinska Institute, University of Cape Town
Keywords: SARS-CoV-2, spike protein subunit vaccine, mice and primates, immune response
Summary of Study: Adjuvanted protein immunization with soluble SARS-CoV-2 Spike trimers, stabilized in prefusion conformation, results in potent antibody responses in mice and rhesus macaques, with neutralizing antibody titers exceeding those typically measured in SARS-CoV-2 seropositive humans by more than one order of magnitude.
References: PMID: 33842900 / doi: 10.1016/j.xcrm.2021.10052
Contact Info: Ben Murrell: [email protected]; Daniel Sheward: [email protected], Gunilla Karlsson Hedestam: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379121000689?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Karolinska Institute, University of Cape Town
Keywords: SARS-CoV-2, spike protein subunit vaccine, mice and primates, immune response
Summary of Study: Adjuvanted protein immunization with soluble SARS-CoV-2 Spike trimers, stabilized in prefusion conformation, results in potent antibody responses in mice and rhesus macaques, with neutralizing antibody titers exceeding those typically measured in SARS-CoV-2 seropositive humans by more than one order of magnitude.
References: PMID: 33842900 / doi: 10.1016/j.xcrm.2021.10052
Contact Info: Ben Murrell: [email protected]; Daniel Sheward: [email protected], Gunilla Karlsson Hedestam: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379121000689?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: The Wistar Institute; Inovio Pharmaceuticals; Bioqual
Keywords: SARS-CoV-2, DNA vaccine, immunogenicity, immune response, adaptive immune response, primates
Summary of Study: INO-4800, an intradermal-delivered SARS-CoV-2 spike DNA vaccine, induced both humoral and cellular arms of the adaptive immune system.
References: PMID: 34604818 / doi: 10.1016/j.xcrm.2021.100420
Contact Info: Kate Broderick: [email protected]; David Weiner: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379121002822?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: The Wistar Institute; Inovio Pharmaceuticals; Bioqual
Keywords: SARS-CoV-2, DNA vaccine, immunogenicity, immune response, adaptive immune response, primates
Summary of Study: INO-4800, an intradermal-delivered SARS-CoV-2 spike DNA vaccine, induced both humoral and cellular arms of the adaptive immune system.
References: PMID: 34604818 / doi: 10.1016/j.xcrm.2021.100420
Contact Info: Kate Broderick: [email protected]; David Weiner: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379121002822?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Beth Israel Deaconess Medical Center, MIT, Harvard
Keywords: SARS-CoV-2, DNA- and Ad26-based vaccines, serum profiles, primates
Summary of Study: Data highlight the similarities between infection and vaccine induced humoral immunity for SARS-Cov-2 and cross-reactivity of these responses to other CoVs.
References: PMID: 33692201 / doi: 10.1128/JVI.00117-21
Contact Info: Dan Barouch: [email protected]
URL: https://journals.asm.org/doi/10.1128/JVI.00117-21?url_ver=Z39.88-2003&rfr_id=or…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Beth Israel Deaconess Medical Center, MIT, Harvard
Keywords: SARS-CoV-2, DNA- and Ad26-based vaccines, serum profiles, primates
Summary of Study: Data highlight the similarities between infection and vaccine induced humoral immunity for SARS-Cov-2 and cross-reactivity of these responses to other CoVs.
References: PMID: 33692201 / doi: 10.1128/JVI.00117-21
Contact Info: Dan Barouch: [email protected]
URL: https://journals.asm.org/doi/10.1128/JVI.00117-21?url_ver=Z39.88-2003&rfr_id=or…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Univ. of Pennsylvania Perelman School of Medicine
Keywords: SARS-CoV-2, D614G Spike Mutation, Vaccinated and immune sera, neutralization, primates
Summary of Study: Vaccinated NHPs using the nucleoside-modified mRNA-LNP vaccine platform encoding four differentSARS-CoV-2 spike immunogens generate antibody responses that not only recognize the G614 mutation that has taken over the pandemic, but also have stronger titers of neutralization to this virus variant.
References: PMID: 33306985/doi: 10.1016/j.chom.2020.11.012
Contact Info: Drew Weissman (no contact information)
URL: https://www.sciencedirect.com/science/article/pii/S193131282030634X?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Univ. of Pennsylvania Perelman School of Medicine
Keywords: SARS-CoV-2, D614G Spike Mutation, Vaccinated and immune sera, neutralization, primates
Summary of Study: Vaccinated NHPs using the nucleoside-modified mRNA-LNP vaccine platform encoding four differentSARS-CoV-2 spike immunogens generate antibody responses that not only recognize the G614 mutation that has taken over the pandemic, but also have stronger titers of neutralization to this virus variant.
References: PMID: 33306985/doi: 10.1016/j.chom.2020.11.012
Contact Info: Drew Weissman (no contact information)
URL: https://www.sciencedirect.com/science/article/pii/S193131282030634X?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Shiga University of Medical Science, Otsu, Japan
Keywords: SARS-CoV-2, severe acute respiratory syndrome, immune response, primates
Summary of Study: Cynomolgus macaques infected with SARS-CoV-2 showed body temperature rises and X-ray radiographic pneumonia without life-threatening clinical signs of disease. Because of similar symptoms to approximately 80% of patients, cynomolgus macaques are appropriate to extrapolate the efficacy of vaccines and antiviral drugs for humans.
References: PMID: 33412411/doi: 10.1016/j.virol.2020.12.013
Contact Info: Yasushi Itoh (no contact information)
URL: https://www.sciencedirect.com/science/article/pii/S0042682220302609?via%3Dihub=
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Shiga University of Medical Science, Otsu, Japan
Keywords: SARS-CoV-2, severe acute respiratory syndrome, immune response, primates
Summary of Study: Cynomolgus macaques infected with SARS-CoV-2 showed body temperature rises and X-ray radiographic pneumonia without life-threatening clinical signs of disease. Because of similar symptoms to approximately 80% of patients, cynomolgus macaques are appropriate to extrapolate the efficacy of vaccines and antiviral drugs for humans.
References: PMID: 33412411/doi: 10.1016/j.virol.2020.12.013
Contact Info: Yasushi Itoh (no contact information)
URL: https://www.sciencedirect.com/science/article/pii/S0042682220302609?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Universite de Paris, Institut Pasteur and others
Keywords: SARS-CoV-2, mathematical model, viral dynamics, immune response, viral clearance, primates
Summary of Study: Results provide estimates of SARS-CoV-2 viral kinetic parameters in an experimental model of mild infection and they provide means to assess the efficacy of future antiviral treatments.
References: PMID: 33730053 / doi: 10.1371/journal.pcbi.1008785
Contact Info: Antonio Goncalves: [email protected]
URL: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008785
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Universite de Paris, Institut Pasteur and others
Keywords: SARS-CoV-2, mathematical model, viral dynamics, immune response, viral clearance, primates
Summary of Study: Results provide estimates of SARS-CoV-2 viral kinetic parameters in an experimental model of mild infection and they provide means to assess the efficacy of future antiviral treatments.
References: PMID: 33730053 / doi: 10.1371/journal.pcbi.1008785
Contact Info: Antonio Goncalves: [email protected]
URL: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008785
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIAID; University of Colorado School of Medicine
Keywords: SARS-CoV-2, role of T cells in recovery, immune response, primates
Summary of Study: Results suggest that T cells are not critical for recovery from acute SARS-CoV-2 infections in the rhesus macaque model (which develop only mild COVID-19, similar to most humans), pointing toward B cell responses and antibodies as the essential mediators of protection from re-exposure.
References: PMID: 34311582 / doi: 10.1128/mBio.01503-21
Contact Info: Kim Hasenkrug: [email protected]
URL: https://journals.asm.org/doi/10.1128/mBio.01503-21
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIAID; University of Colorado School of Medicine
Keywords: SARS-CoV-2, role of T cells in recovery, immune response, primates
Summary of Study: Results suggest that T cells are not critical for recovery from acute SARS-CoV-2 infections in the rhesus macaque model (which develop only mild COVID-19, similar to most humans), pointing toward B cell responses and antibodies as the essential mediators of protection from re-exposure.
References: PMID: 34311582 / doi: 10.1128/mBio.01503-21
Contact Info: Kim Hasenkrug: [email protected]
URL: https://journals.asm.org/doi/10.1128/mBio.01503-21
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Indian Veterinary Research Institute and others
Keywords: SARS-CoV-2, domestic and wild animal species, public health
Summary of Study: This review analyzes the current evidence of SARS-CoV-2 natural infection in domestic and wild animal species and their possible implications on public health.
References: PMID: 33892621 / doi: 10.1080/01652176/2021.1921311
Contact Info: Khan Sharun: [email protected]; Kuldeep Dhama: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128218/pdf/TVEQ_41_1921311.pdf
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Indian Veterinary Research Institute and others
Keywords: SARS-CoV-2, domestic and wild animal species, public health
Summary of Study: This review analyzes the current evidence of SARS-CoV-2 natural infection in domestic and wild animal species and their possible implications on public health.
References: PMID: 33892621 / doi: 10.1080/01652176/2021.1921311
Contact Info: Khan Sharun: [email protected]; Kuldeep Dhama: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128218/pdf/TVEQ_41_1921311.pdf
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences, Nanjing University
Keywords: SARS-CoV-2, pathology, primates
Summary of Study: SARS-CoV-2-infected northern pig-tailed macaques could be considered as a critically ill animal model in COVID-19 research.
References: PMID: 33998182 / doi: 10.24272/j.issn.2095-8137.2020.334
Contact Info: Yong-Tang Zheng: [email protected]
URL: http://www.zoores.ac.cn/article/doi/10.24272/j.issn.2095-8137.2020.334
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences, Nanjing University
Keywords: SARS-CoV-2, pathology, primates
Summary of Study: SARS-CoV-2-infected northern pig-tailed macaques could be considered as a critically ill animal model in COVID-19 research.
References: PMID: 33998182 / doi: 10.24272/j.issn.2095-8137.2020.334
Contact Info: Yong-Tang Zheng: [email protected]
URL: http://www.zoores.ac.cn/article/doi/10.24272/j.issn.2095-8137.2020.334
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Karolinska Institutet; University of Cape Town
Keywords: SARS-CoV-2, virus genomic variants, antigenic sin, boost, passive immunization, mice, primates
Summary of Study: A single dose of adjuvanted beta variant receptor binding domain (RBD) protein broadens neutralizing antibody responses to heterologous VOCs.
References: PMID: 34723224 / doi: 10.1016/j.xcrm.2021.100450
Contact Info: Daniel Sheward: [email protected]; Gunilla Karlsson Hedestam: [email protected]; Ben Murrell: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379121003189?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Karolinska Institutet; University of Cape Town
Keywords: SARS-CoV-2, virus genomic variants, antigenic sin, boost, passive immunization, mice, primates
Summary of Study: A single dose of adjuvanted beta variant receptor binding domain (RBD) protein broadens neutralizing antibody responses to heterologous VOCs.
References: PMID: 34723224 / doi: 10.1016/j.xcrm.2021.100450
Contact Info: Daniel Sheward: [email protected]; Gunilla Karlsson Hedestam: [email protected]; Ben Murrell: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379121003189?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Texas Medical Branch, Pfizer
Keywords: SARS-CoV-2, vaccine-elicited immunity, virus variant, primates
Summary of Study: The D614G mutation modestly reduced SARS-CoV-2 neutralization by BNT162b2 vaccine-elicited mouse, rhesus, and human sera, concurring with the 95% vaccine efficacy observed in clinical trial.
References: PMID: 33767200 / doi: 10.1038/s41541-021-00313-8
Contact Info: Philip Dormitzer: philip,[email protected]
URL: https://www.nature.com/articles/s41541-021-00313-8
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Texas Medical Branch, Pfizer
Keywords: SARS-CoV-2, vaccine-elicited immunity, virus variant, primates
Summary of Study: The D614G mutation modestly reduced SARS-CoV-2 neutralization by BNT162b2 vaccine-elicited mouse, rhesus, and human sera, concurring with the 95% vaccine efficacy observed in clinical trial.
References: PMID: 33767200 / doi: 10.1038/s41541-021-00313-8
Contact Info: Philip Dormitzer: philip,[email protected]
URL: https://www.nature.com/articles/s41541-021-00313-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Emory University School of Medicine
Keywords: SARS-CoV-2, several animal species, anti-viral therapeutic, vaccine development, primates
Summary of Study: Summarizing key features, strengths and weaknesses of animal models for SARS-CoV-2, focusing on their application in anti-viral therapeutic and vaccine development.
References: PMID: 33906125 / doi: 10.1016/j.coviro.2021.03.009
Contact Info: Anice Lowen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1879625721000316?via%3Dihub=
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Emory University School of Medicine
Keywords: SARS-CoV-2, several animal species, anti-viral therapeutic, vaccine development, primates
Summary of Study: Summarizing key features, strengths and weaknesses of animal models for SARS-CoV-2, focusing on their application in anti-viral therapeutic and vaccine development.
References: PMID: 33906125 / doi: 10.1016/j.coviro.2021.03.009
Contact Info: Anice Lowen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1879625721000316?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Copycat Sciences; Sporos Bioventures
Keywords: SARS-CoV-2, redelivery, analysis of the preclinical data and clinical efficacy, primates
Summary of Study: The gap between the strong preclinical data with remdesivir (RDV) across many virus models and its questionable clinical activity suggests that assumptions are being made at the preclinical level that do not reflect the conditions observed in patients.
References: PMID: 34252308 / doi: 10.1128/AAC.01117-21
Contact Info: Victoria Yan: [email protected]
URL: https://journals.asm.org/doi/10.1128/AAC.01117-21?url_ver=Z39.88-2003&rfr_id=or…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Copycat Sciences; Sporos Bioventures
Keywords: SARS-CoV-2, redelivery, analysis of the preclinical data and clinical efficacy, primates
Summary of Study: The gap between the strong preclinical data with remdesivir (RDV) across many virus models and its questionable clinical activity suggests that assumptions are being made at the preclinical level that do not reflect the conditions observed in patients.
References: PMID: 34252308 / doi: 10.1128/AAC.01117-21
Contact Info: Victoria Yan: [email protected]
URL: https://journals.asm.org/doi/10.1128/AAC.01117-21?url_ver=Z39.88-2003&rfr_id=or…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Perelman School of Medicine (UPenn)
Keywords: SARS-CoV-2, clinical and pathologic consequences, ACE2 decoy protein, primates
Summary of Study: The ACE2 decoy (soluble forms of angiotensin-converting enzyme 2) gene therapy approach could be effectively deployed to vulnerable populations in the COVID-19 pandemic and potentially to broader populations at the outset of future coronavirus pandemics.
References: PMID: 34265018 / doi: 10.1371/journal.ppat.1009544
Contact Info: James Wilson: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009544
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Perelman School of Medicine (UPenn)
Keywords: SARS-CoV-2, clinical and pathologic consequences, ACE2 decoy protein, primates
Summary of Study: The ACE2 decoy (soluble forms of angiotensin-converting enzyme 2) gene therapy approach could be effectively deployed to vulnerable populations in the COVID-19 pandemic and potentially to broader populations at the outset of future coronavirus pandemics.
References: PMID: 34265018 / doi: 10.1371/journal.ppat.1009544
Contact Info: James Wilson: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009544
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Iowa; University of Florida
Keywords: SARS-CoV-2, meta analysis, airway mucus, mucin glycoproteins, inflammation, primates
Summary of Study: Ferrets, nonhuman primates, and cats may have advantages over other models to investigate mucus in COVID-19.
References: PMID: 34794359 / doi: 10.1177/03009858211058837
Contact Info: not available
URL: https://journals.sagepub.com/doi/10.1177/03009858211058837?url_ver=Z39.88-2003&…
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Iowa; University of Florida
Keywords: SARS-CoV-2, meta analysis, airway mucus, mucin glycoproteins, inflammation, primates
Summary of Study: Ferrets, nonhuman primates, and cats may have advantages over other models to investigate mucus in COVID-19.
References: PMID: 34794359 / doi: 10.1177/03009858211058837
Contact Info: not available
URL: https://journals.sagepub.com/doi/10.1177/03009858211058837?url_ver=Z39.88-2003&…
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Dalhousie University; University of Calgary
Keywords: SARS-CoV-2, anthropozoonosis, virus transmission between the animal species, primates
Summary of Study: While the risk of transmission of SARS-CoV-2 via wastewater is low, tracing of viral RNA in wastewater does provide a unique testing approach to help protect NHPs at zoos and wildlife sanctuaries.
References: PMID: 34662463 / doi: 10.1002/ajp.23340
Contact Info: Graham Dellaire: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/ajp.23340
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Dalhousie University; University of Calgary
Keywords: SARS-CoV-2, anthropozoonosis, virus transmission between the animal species, primates
Summary of Study: While the risk of transmission of SARS-CoV-2 via wastewater is low, tracing of viral RNA in wastewater does provide a unique testing approach to help protect NHPs at zoos and wildlife sanctuaries.
References: PMID: 34662463 / doi: 10.1002/ajp.23340
Contact Info: Graham Dellaire: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/ajp.23340
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane NPRC, North Carolina State University
Keywords: SARS-CoV-2, portable, ultrasensitive saliva-based virus assay, primates
Summary of Study: CRISPR-FDS determined that mean SARS-Cov-2 RNA levels were 3.6 fold to 124-fold higher, and more stable, in oropharyngeal versus nasal swab samples from nonhuman primates at all time points after infection, suggesting that saliva may represent a more robust diagnostic sample than nasal swabs both early and later in infection.
References: PMID: 33310733 / doi: 10.1126/sciadv.abe3703
Contact Info: Tony Hu: [email protected]
URL: https://advances.sciencemag.org/content/7/2/eabe3703
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane NPRC, North Carolina State University
Keywords: SARS-CoV-2, portable, ultrasensitive saliva-based virus assay, primates
Summary of Study: CRISPR-FDS determined that mean SARS-Cov-2 RNA levels were 3.6 fold to 124-fold higher, and more stable, in oropharyngeal versus nasal swab samples from nonhuman primates at all time points after infection, suggesting that saliva may represent a more robust diagnostic sample than nasal swabs both early and later in infection.
References: PMID: 33310733 / doi: 10.1126/sciadv.abe3703
Contact Info: Tony Hu: [email protected]
URL: https://advances.sciencemag.org/content/7/2/eabe3703