Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences, Hynnan Key Laboratory of Vaccine Research, University of Massachusetts Medical School
Keywords: SARS-CoV-2, T cells, immune response, primates
Summary of Study: Six peptides were defined as the most frequently recognized T cell epitopes, and overlapped to produce three main long epitopes. This finding may provide a convenient pattern in the detection of T cell responses for the development of new vaccines and provides a novel target in the diagnosis of patients with COVID-19.
References: PMID: 33980582 / doi: 10.4049/jimmunol.2000922
Contact Info: Wei Cun: [email protected]
URL: https://www.jimmunol.org/content/206/11/2527.long
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences, Hynnan Key Laboratory of Vaccine Research, University of Massachusetts Medical School
Keywords: SARS-CoV-2, T cells, immune response, primates
Summary of Study: Six peptides were defined as the most frequently recognized T cell epitopes, and overlapped to produce three main long epitopes. This finding may provide a convenient pattern in the detection of T cell responses for the development of new vaccines and provides a novel target in the diagnosis of patients with COVID-19.
References: PMID: 33980582 / doi: 10.4049/jimmunol.2000922
Contact Info: Wei Cun: [email protected]
URL: https://www.jimmunol.org/content/206/11/2527.long
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Ottawa; Ottawa Hospital Research Institute; Institut du Cancer de Montreal; University of Calgary
Keywords: SARS-CoV-2, attenuated vaccinia virus vector, spike receptor binding domain, immune response, mice, primates
Summary of Study: Robust immune responses and protective immunity against SARS-CoV-2 variants were demonstrated after only a single dose of a temperature stable vaccine candidate (TOH-Vac1) that uses a replication-competent, attenuated vaccinia virus as a vector to express a membrane-tethered spike receptor binding domain antigen.
References: PMID: 34687845 / doi: 10.1016/j.ymthe.2021.10.008
Contact Info: John Bell: [email protected]; Carolina Ilkow: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1525001621005153?via%3Dihub=
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Ottawa; Ottawa Hospital Research Institute; Institut du Cancer de Montreal; University of Calgary
Keywords: SARS-CoV-2, attenuated vaccinia virus vector, spike receptor binding domain, immune response, mice, primates
Summary of Study: Robust immune responses and protective immunity against SARS-CoV-2 variants were demonstrated after only a single dose of a temperature stable vaccine candidate (TOH-Vac1) that uses a replication-competent, attenuated vaccinia virus as a vector to express a membrane-tethered spike receptor binding domain antigen.
References: PMID: 34687845 / doi: 10.1016/j.ymthe.2021.10.008
Contact Info: John Bell: [email protected]; Carolina Ilkow: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1525001621005153?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Shandong Boan Biotech Co., National Institutes for Food and Drug Control, Shuimu Biosciences, and others
Keywords: SARS-CoV-2, neutralizing antibodies, structural analysis, primates
Summary of Study: CA521^FALA is a promising antibody that reacts with SARS-CoV-2 Spike protein to strongly neutralize its activity.
References: PMID: 33893388 / doi: 10.1038/s42003-021-02029-w
Contact Info: Lan Wang: [email protected]; Yong-Qiang Deng: [email protected]; Changlin Dou: [email protected]
URL: https://www.nature.com/articles/s42003-021-02029-w
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Shandong Boan Biotech Co., National Institutes for Food and Drug Control, Shuimu Biosciences, and others
Keywords: SARS-CoV-2, neutralizing antibodies, structural analysis, primates
Summary of Study: CA521^FALA is a promising antibody that reacts with SARS-CoV-2 Spike protein to strongly neutralize its activity.
References: PMID: 33893388 / doi: 10.1038/s42003-021-02029-w
Contact Info: Lan Wang: [email protected]; Yong-Qiang Deng: [email protected]; Changlin Dou: [email protected]
URL: https://www.nature.com/articles/s42003-021-02029-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences; Tsinghua University; Advaccine Biopharmaceuticals (Suzhou)
Keywords: SARS-CoV-2, B cells, Toll-like receptor, preclinical study, virus-like particle, pathogen-like antigen, primates
Summary of Study: A PLA-based COVID-19 vaccine candidate could potentially serve as an alternative option for coping with the SARS-CoV-2 pandemic.
References: PMID: 34723223 / doi: 10.1016/j.xcrm.2021.100448
Contact Info: Zhaolin Hua: [email protected]; Hongyu Deng: [email protected]; Baidong Hou: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379121003165?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences; Tsinghua University; Advaccine Biopharmaceuticals (Suzhou)
Keywords: SARS-CoV-2, B cells, Toll-like receptor, preclinical study, virus-like particle, pathogen-like antigen, primates
Summary of Study: A PLA-based COVID-19 vaccine candidate could potentially serve as an alternative option for coping with the SARS-CoV-2 pandemic.
References: PMID: 34723223 / doi: 10.1016/j.xcrm.2021.100448
Contact Info: Zhaolin Hua: [email protected]; Hongyu Deng: [email protected]; Baidong Hou: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379121003165?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: ImmunityBio, Inc.; IosBio; Battelle Biomedical Research Center; NantKwest, Inc.
Keywords: SARS-CoV-2, dual-antigen vaccine, adenovirus vector, immune response, virus replication, primates
Summary of Study: In the rhesus macaque model, SC prime vaccination with two oral boosts with the dual-antigen hAd5 S-Fusion + N-ETSD vaccine provides protection from SARS-CoV-2 infection for both nasal and lung airways.
References: PMID: 34603305 / doi: 10.3389/fimmu.2021.729837
Contact Info: Patrick Soon-Shiong: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.729837/full
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: ImmunityBio, Inc.; IosBio; Battelle Biomedical Research Center; NantKwest, Inc.
Keywords: SARS-CoV-2, dual-antigen vaccine, adenovirus vector, immune response, virus replication, primates
Summary of Study: In the rhesus macaque model, SC prime vaccination with two oral boosts with the dual-antigen hAd5 S-Fusion + N-ETSD vaccine provides protection from SARS-CoV-2 infection for both nasal and lung airways.
References: PMID: 34603305 / doi: 10.3389/fimmu.2021.729837
Contact Info: Patrick Soon-Shiong: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.729837/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Oxford, Public Health England, The Pirbright Institute
Keywords: SARS-CoV-2, vaccine, immune response, pathology, primates
Summary of Study: Lung pathology caused by SARS-CoV-2 mediated pneumonia is reduced in rhesus macaques by prior vaccination with ChAdOx1 nCoV-19, which induced neutralising antibody responses after a single intramuscular administration.
References: PMID: 34312487 / doi: 10.1038/s42003-021-02443-0
Contact Info: Sarah Gilbert: [email protected]
URL: https://www.nature.com/articles/s42003-021-02443-0
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Oxford, Public Health England, The Pirbright Institute
Keywords: SARS-CoV-2, vaccine, immune response, pathology, primates
Summary of Study: Lung pathology caused by SARS-CoV-2 mediated pneumonia is reduced in rhesus macaques by prior vaccination with ChAdOx1 nCoV-19, which induced neutralising antibody responses after a single intramuscular administration.
References: PMID: 34312487 / doi: 10.1038/s42003-021-02443-0
Contact Info: Sarah Gilbert: [email protected]
URL: https://www.nature.com/articles/s42003-021-02443-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIAID; University of Colorado School of Medicine
Keywords: SARS-CoV-2, role of T cells in recovery, immune response, primates
Summary of Study: Results suggest that T cells are not critical for recovery from acute SARS-CoV-2 infections in the rhesus macaque model (which develop only mild COVID-19, similar to most humans), pointing toward B cell responses and antibodies as the essential mediators of protection from re-exposure.
References: PMID: 34311582 / doi: 10.1128/mBio.01503-21
Contact Info: Kim Hasenkrug: [email protected]
URL: https://journals.asm.org/doi/10.1128/mBio.01503-21
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIAID; University of Colorado School of Medicine
Keywords: SARS-CoV-2, role of T cells in recovery, immune response, primates
Summary of Study: Results suggest that T cells are not critical for recovery from acute SARS-CoV-2 infections in the rhesus macaque model (which develop only mild COVID-19, similar to most humans), pointing toward B cell responses and antibodies as the essential mediators of protection from re-exposure.
References: PMID: 34311582 / doi: 10.1128/mBio.01503-21
Contact Info: Kim Hasenkrug: [email protected]
URL: https://journals.asm.org/doi/10.1128/mBio.01503-21
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; CureVac AG
Keywords: SARS-CoV-2, mRNA vaccine candidate, humoral and cellular immune responses, primates
Summary of Study: Prime boost vaccination of rhesus macaques with 4 ug of CV07050101 elicited neither a uniform nor a robust immune response. However, vaccination using 8 ug of the same vaccine was protective in an NHP challenge study.
References: PMID: 34452509 / doi: 10.3390/v13081645
Contact Info: Vincent Munster: [email protected]
URL: https://www.mdpi.com/1999-4915/13/8/1645
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; CureVac AG
Keywords: SARS-CoV-2, mRNA vaccine candidate, humoral and cellular immune responses, primates
Summary of Study: Prime boost vaccination of rhesus macaques with 4 ug of CV07050101 elicited neither a uniform nor a robust immune response. However, vaccination using 8 ug of the same vaccine was protective in an NHP challenge study.
References: PMID: 34452509 / doi: 10.3390/v13081645
Contact Info: Vincent Munster: [email protected]
URL: https://www.mdpi.com/1999-4915/13/8/1645
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Sichuan University; Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, review of the current animal models, pathology, immune response, use for the testing therapeutics and vaccines, mice, hamsters, nonhuman primates, and ferrets
Summary of Study: A variety of animal models have been developed to demonstrate the transmission, pathogenesis, and immunology induced by SARS-CoV-2 and to evaluate the immunomodulatory and antiviral drugs and vaccines against COVID-19. None of these models can completely recapitulate the changes seen in COVID-19 patients. It may be beneficial for investigators to apply appropriate options of animal models depending on the scientific goals.
References: PMID: 34909757 / doi: 10.1002/mco2.98
Contact Info: Shuaiyao Lu: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662225/pdf/MCO2-2-548.pdf
NHP Species: african green monkeys, rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Sichuan University; Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, review of the current animal models, pathology, immune response, use for the testing therapeutics and vaccines, mice, hamsters, nonhuman primates, and ferrets
Summary of Study: A variety of animal models have been developed to demonstrate the transmission, pathogenesis, and immunology induced by SARS-CoV-2 and to evaluate the immunomodulatory and antiviral drugs and vaccines against COVID-19. None of these models can completely recapitulate the changes seen in COVID-19 patients. It may be beneficial for investigators to apply appropriate options of animal models depending on the scientific goals.
References: PMID: 34909757 / doi: 10.1002/mco2.98
Contact Info: Shuaiyao Lu: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662225/pdf/MCO2-2-548.pdf
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Shanghai Zerun Biotechnology Co., Ltd.; Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College; Shanghai Medical College, Fudan University; Wuhan University; National Institute for Food and Drug Control (NIFDC)
Keywords: SARS-CoV-2, recombinant vaccine, spike trimer, immunogenicity, mice, hamsters, primates
Summary of Study: A recombinant spike protein vaccine adjuvanted with aluminium hydroxide and CpG 7909 showed high immunogenicity and good protective efficacy in preclinical studies, supporting further clinical trials.
References: PMID: 34750014 / doi: 10.1016/j.vaccine.2021.10.066
Contact Info: Ge Liu: [email protected]; Jiangning Liu: [email protected]; Youhua Xie: [email protected]; Zhongyu Hu: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21013992?via%3Dihub=
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Shanghai Zerun Biotechnology Co., Ltd.; Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College; Shanghai Medical College, Fudan University; Wuhan University; National Institute for Food and Drug Control (NIFDC)
Keywords: SARS-CoV-2, recombinant vaccine, spike trimer, immunogenicity, mice, hamsters, primates
Summary of Study: A recombinant spike protein vaccine adjuvanted with aluminium hydroxide and CpG 7909 showed high immunogenicity and good protective efficacy in preclinical studies, supporting further clinical trials.
References: PMID: 34750014 / doi: 10.1016/j.vaccine.2021.10.066
Contact Info: Ge Liu: [email protected]; Jiangning Liu: [email protected]; Youhua Xie: [email protected]; Zhongyu Hu: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21013992?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Henry M. Jackson Foundation for the Advancement of Military Medicine; Washington University; National Cancer Institute/NIH; BIOQUAL; and others
Keywords: SARS-CoV-2, nanoparticle protein vaccine, humoral and cellular immune responses, primates
Summary of Study: Findings support the continued development of SARS-CoV-2 RBD ferritin nanoparticle vaccines (RFN) for managing COVID-19 and related SARS-CoV-like virus outbreaks.
References: PMID: 34470866 / doi: 10.1073/pnas.2106433118
Contact Info: Kayvon Modjarrad: [email protected]; Diane Bolton: [email protected]
URL: https://www.pnas.org/content/118/38/e2106433118.long
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Henry M. Jackson Foundation for the Advancement of Military Medicine; Washington University; National Cancer Institute/NIH; BIOQUAL; and others
Keywords: SARS-CoV-2, nanoparticle protein vaccine, humoral and cellular immune responses, primates
Summary of Study: Findings support the continued development of SARS-CoV-2 RBD ferritin nanoparticle vaccines (RFN) for managing COVID-19 and related SARS-CoV-like virus outbreaks.
References: PMID: 34470866 / doi: 10.1073/pnas.2106433118
Contact Info: Kayvon Modjarrad: [email protected]; Diane Bolton: [email protected]
URL: https://www.pnas.org/content/118/38/e2106433118.long
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences, Kunming Institute of Zoology; Institute of Infectious Diseases, Shenzhen Bay Laboratory; School of Medicine, Tsinghua University
Keywords: SARS-CoV-2, receptor-binding domain subunit vaccine, humoral and cellular immune responses, pathology, primates
Summary of Study: A trimeric SARS-CoV-2 receptor-binding domain (RBD) subunit vaccine that stimulates the natural structure of the spike (S) trimer glycoprotein is highly immunogenic and safe, providing long-lasting, broad, and significant immunity protection in NHPs. The vaccine-induced antibodies can effectively neutralize the SARS-CoV-2 501Y.V2 variant. A booster vaccination can quickly activate the memory immune response to avoid re-infection.
References: PMID: 34179862 / doi: 10.1016/j.xinn.2021.100140
Contact Info: Limin Yang: [email protected]; Yong-tang Zheng: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214323/
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences, Kunming Institute of Zoology; Institute of Infectious Diseases, Shenzhen Bay Laboratory; School of Medicine, Tsinghua University
Keywords: SARS-CoV-2, receptor-binding domain subunit vaccine, humoral and cellular immune responses, pathology, primates
Summary of Study: A trimeric SARS-CoV-2 receptor-binding domain (RBD) subunit vaccine that stimulates the natural structure of the spike (S) trimer glycoprotein is highly immunogenic and safe, providing long-lasting, broad, and significant immunity protection in NHPs. The vaccine-induced antibodies can effectively neutralize the SARS-CoV-2 501Y.V2 variant. A booster vaccination can quickly activate the memory immune response to avoid re-infection.
References: PMID: 34179862 / doi: 10.1016/j.xinn.2021.100140
Contact Info: Limin Yang: [email protected]; Yong-tang Zheng: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214323/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre (BPRC); Eurofins-INGENASA; Erasmus University Medical Center; Utrecht University
Keywords: SARS-CoV-2, post-acute phase, immune response, tomography, virus replication, primates
Summary of Study: NHPs infected with SARS-CoV-2 were followed for up to 6 weeks and monitored for COVID-19-like disease symptoms. Data indicate widespread tissue dissemination of SARS-CoV-2 in individual monkeys and provide evidence for continuing virus replication in lungs and surrounding lymph nodes after alleged convalescence of infection.
References: PMID: 34452537 / doi: 10.3390/v13081673
Contact Info: Ernst Verschoor: [email protected]
URL: https://www.mdpi.com/1999-4915/13/8/1673
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre (BPRC); Eurofins-INGENASA; Erasmus University Medical Center; Utrecht University
Keywords: SARS-CoV-2, post-acute phase, immune response, tomography, virus replication, primates
Summary of Study: NHPs infected with SARS-CoV-2 were followed for up to 6 weeks and monitored for COVID-19-like disease symptoms. Data indicate widespread tissue dissemination of SARS-CoV-2 in individual monkeys and provide evidence for continuing virus replication in lungs and surrounding lymph nodes after alleged convalescence of infection.
References: PMID: 34452537 / doi: 10.3390/v13081673
Contact Info: Ernst Verschoor: [email protected]
URL: https://www.mdpi.com/1999-4915/13/8/1673
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Battelle National Biodefense Institute; Gryphon Scientific LLC, Censeo Insight; Applied Research Associates
Keywords: SARS-CoV-2, inhalation, infection route, virus detection, dose response, primates
Summary of Study: SARS-CoV-2 infection and subsequent disease presentation are dependent on exposure dose in a nonhuman primate model of inhalational COVID-19.
References: PMID: 34424943 / doi: 10.1371/journal.ppat.1009865
Contact Info: Paul Dabisch: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009865
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Battelle National Biodefense Institute; Gryphon Scientific LLC, Censeo Insight; Applied Research Associates
Keywords: SARS-CoV-2, inhalation, infection route, virus detection, dose response, primates
Summary of Study: SARS-CoV-2 infection and subsequent disease presentation are dependent on exposure dose in a nonhuman primate model of inhalational COVID-19.
References: PMID: 34424943 / doi: 10.1371/journal.ppat.1009865
Contact Info: Paul Dabisch: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009865
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; Harvard T.H. Chan School of Public Health; Emory University; Moderna, Bioqual
Keywords: SARS-CoV-2, RNA-vaccine, immune response, virus replication, protection, primates
Summary of Study: Data establish that a two-dose regimen of mRNA-1273 (Moderna vaccine) will be critical for providing upper and lower airway protection against major variants of concern.
References: PMID: 34417590 / doi: 10.1038/s41590-021-02021-0
Contact Info: Barney Graham: [email protected]; Robert Seder: [email protected]
URL: https://www.nature.com/articles/s41590-021-01021-0
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; Harvard T.H. Chan School of Public Health; Emory University; Moderna, Bioqual
Keywords: SARS-CoV-2, RNA-vaccine, immune response, virus replication, protection, primates
Summary of Study: Data establish that a two-dose regimen of mRNA-1273 (Moderna vaccine) will be critical for providing upper and lower airway protection against major variants of concern.
References: PMID: 34417590 / doi: 10.1038/s41590-021-02021-0
Contact Info: Barney Graham: [email protected]; Robert Seder: [email protected]
URL: https://www.nature.com/articles/s41590-021-01021-0
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: The Wistar Institute, Perelman School of Medicine, NIAID, and others
Keywords: MERS-CoV, intradermal and intramuscular delivery, synthetic DNA vaccine, primates
Summary of Study: Results illustrate that a MERS spike antigen synthetic DNA vaccine administered in a 2-dose i.d. EP regimen can have positive impact in an important NHP challenge model protecting against symptoms and pathology.
References: PMID: 33886507 / doi: 10.1172/jci.insight.146082
Contact Info: David Weiner: [email protected]
URL: https://insight.jci.org/articles/view/146082
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: The Wistar Institute, Perelman School of Medicine, NIAID, and others
Keywords: MERS-CoV, intradermal and intramuscular delivery, synthetic DNA vaccine, primates
Summary of Study: Results illustrate that a MERS spike antigen synthetic DNA vaccine administered in a 2-dose i.d. EP regimen can have positive impact in an important NHP challenge model protecting against symptoms and pathology.
References: PMID: 33886507 / doi: 10.1172/jci.insight.146082
Contact Info: David Weiner: [email protected]
URL: https://insight.jci.org/articles/view/146082
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Public Health England & Welcome Trust Centre for Human Genetics
Keywords: SARS-CoV-2, pathogenicity, comparative studies, primates
Summary of Study: SARS-CoV-2 replicates in the upper and lower respiratory tract and causes pulmonary lesions in both rhesus and cynomolgus macaques. This provides convincing evidence that both macaque species authentically represent mild to moderate forms of COVID-19 observed in the majority of the human populations and both species can e used to evaluate the safety and efficacy of interventions proposed against SARS-CoV-2. Importantly, accessing cynomolgus macaques will greatly alleviate the pressures on current rhesus stocks.
References: PMID: 33627662 / doi: 10.1038/s41467-021-21389-9
Contact Info: Miles Carroll: [email protected]
URL: https://www.nature.com/articles/s41467-021-21389-9
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Public Health England & Welcome Trust Centre for Human Genetics
Keywords: SARS-CoV-2, pathogenicity, comparative studies, primates
Summary of Study: SARS-CoV-2 replicates in the upper and lower respiratory tract and causes pulmonary lesions in both rhesus and cynomolgus macaques. This provides convincing evidence that both macaque species authentically represent mild to moderate forms of COVID-19 observed in the majority of the human populations and both species can e used to evaluate the safety and efficacy of interventions proposed against SARS-CoV-2. Importantly, accessing cynomolgus macaques will greatly alleviate the pressures on current rhesus stocks.
References: PMID: 33627662 / doi: 10.1038/s41467-021-21389-9
Contact Info: Miles Carroll: [email protected]
URL: https://www.nature.com/articles/s41467-021-21389-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Wheaten College, Cornell University
Keywords: SARS-CoV-2, virus susceptibility, animal welfare, hamsters, ferrets, primates
Summary of Study: Paper reviews virus susceptibilities in species with frequent human contact, and factors that are best predictors of virus susceptibility.
References: PMID: 34359172 / doi: 10.3390/ani11072044
Contact Info: Kathleen Morgan: [email protected]
URL: https://www.mdpi.com/2076-2615/11/7/2044
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Wheaten College, Cornell University
Keywords: SARS-CoV-2, virus susceptibility, animal welfare, hamsters, ferrets, primates
Summary of Study: Paper reviews virus susceptibilities in species with frequent human contact, and factors that are best predictors of virus susceptibility.
References: PMID: 34359172 / doi: 10.3390/ani11072044
Contact Info: Kathleen Morgan: [email protected]
URL: https://www.mdpi.com/2076-2615/11/7/2044
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP, NIH
Keywords: SARS-CoV-2, the use of primates for COVID research, animal resources
Summary of Study: The SARS-CoV-2/COVID-19 pandemic has significantly increased the demand for specific-pathogen-free (SFP) NHPs for development of vaccines and therapeutics. Non-SPF animals, which are available in greater numbers and include well-characterized primate species, should be considered in lieu of limited SPF animals for appropriate research studies.
References: doi: 10.1038/s41684-021-00810-2
Contact Info: Miguel Contreras: miguel.contreras
URL: https://www.nature.com/articles/s41684-021-00810-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP, NIH
Keywords: SARS-CoV-2, the use of primates for COVID research, animal resources
Summary of Study: The SARS-CoV-2/COVID-19 pandemic has significantly increased the demand for specific-pathogen-free (SFP) NHPs for development of vaccines and therapeutics. Non-SPF animals, which are available in greater numbers and include well-characterized primate species, should be considered in lieu of limited SPF animals for appropriate research studies.
References: doi: 10.1038/s41684-021-00810-2
Contact Info: Miguel Contreras: miguel.contreras
URL: https://www.nature.com/articles/s41684-021-00810-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Statens Serum Institute; Robert Koch Institute; BIOQUAL; University of Southern Denmark
Keywords: SARS-CoV-2, DNA plasmid vaccine, immune response, primates
Summary of Study: The candidate plasmid DNA vaccine encoding the SARS-CoV-2 spike protein is immunogenic in different models and confers protection against lung infection in nonhuman primates. Further evaluation of this DNA vaccine candidate in clinical trials is warranted.
References: PMID: 34930909 / doi: 10.1038/s41541-021-00419-z
Contact Info: Anders Fomsgaard: [email protected]
URL: https://www.nature.com/articles/s41541-021-00419-z
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Statens Serum Institute; Robert Koch Institute; BIOQUAL; University of Southern Denmark
Keywords: SARS-CoV-2, DNA plasmid vaccine, immune response, primates
Summary of Study: The candidate plasmid DNA vaccine encoding the SARS-CoV-2 spike protein is immunogenic in different models and confers protection against lung infection in nonhuman primates. Further evaluation of this DNA vaccine candidate in clinical trials is warranted.
References: PMID: 34930909 / doi: 10.1038/s41541-021-00419-z
Contact Info: Anders Fomsgaard: [email protected]
URL: https://www.nature.com/articles/s41541-021-00419-z
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Universite Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases; University of Amsterdam; Universite de Paris, INSERM, IAME; University of Texas Medical Branch at Galveston; Galveston National Laboratory; Icahn School of Medicine at Mount Sinai; The Scripps Research Institute; Duke Human Vaccine Institute & Department of Surgery; Nexelis; The University of Maryland School of Medicine; Institut Pasteur; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, neutralizing antibody, prophylactic, pathology, mice, hamsters, primates
Summary of Study: COVA1-18, a neutralizing antibody highly potent against the B.1.1.7 isolate, has a strong antiviral activity in three preclinical models and could be a valuable candidate for further clinical evaluation.
References: PMID: 34671037 / doi: 10.1038/s41467-021-26354-0
Contact Info: Rogier Sanders: [email protected]; Marit van Gils: [email protected]; Roger Le Grand: [email protected]
URL: https://www.nature.com/articles/s41467-021-26354-0
NHP Species:
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Universite Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases; University of Amsterdam; Universite de Paris, INSERM, IAME; University of Texas Medical Branch at Galveston; Galveston National Laboratory; Icahn School of Medicine at Mount Sinai; The Scripps Research Institute; Duke Human Vaccine Institute & Department of Surgery; Nexelis; The University of Maryland School of Medicine; Institut Pasteur; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, neutralizing antibody, prophylactic, pathology, mice, hamsters, primates
Summary of Study: COVA1-18, a neutralizing antibody highly potent against the B.1.1.7 isolate, has a strong antiviral activity in three preclinical models and could be a valuable candidate for further clinical evaluation.
References: PMID: 34671037 / doi: 10.1038/s41467-021-26354-0
Contact Info: Rogier Sanders: [email protected]; Marit van Gils: [email protected]; Roger Le Grand: [email protected]
URL: https://www.nature.com/articles/s41467-021-26354-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Pasteur Institute of Iran; Amirabad Virology Laboratory; Tarbiat Modares University; University of Tehran; Islamic Azad University; Hamadan University of Medical Sciences; Darou Pakhsh Pharmaceutical; Arena Diagnostic; and others.
Keywords: SARS-CoV-2, inactivated whole-virus vaccine, safety, immune response, guinea pig, rabbit, mice, primates
Summary of Study: Rhesus macaques were immunised with the two-dose schedule of 5 or 3 ug of the B1V1-CovIran vaccine and showed highly efficient protection against 10^4 TCID50 of SARS-CoV-2 intratracheal challenge compared with the control group.
References: PMID: 34699647 / doi: 10.1002/rmv.2305
Contact Info: Reza Aalizadeh: [email protected]; Hasan Jalili: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/rmv.2305
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Pasteur Institute of Iran; Amirabad Virology Laboratory; Tarbiat Modares University; University of Tehran; Islamic Azad University; Hamadan University of Medical Sciences; Darou Pakhsh Pharmaceutical; Arena Diagnostic; and others.
Keywords: SARS-CoV-2, inactivated whole-virus vaccine, safety, immune response, guinea pig, rabbit, mice, primates
Summary of Study: Rhesus macaques were immunised with the two-dose schedule of 5 or 3 ug of the B1V1-CovIran vaccine and showed highly efficient protection against 10^4 TCID50 of SARS-CoV-2 intratracheal challenge compared with the control group.
References: PMID: 34699647 / doi: 10.1002/rmv.2305
Contact Info: Reza Aalizadeh: [email protected]; Hasan Jalili: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/rmv.2305
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Universite paris-Saclay/Inserm/Cea; Pereman School of Medicine; Novartis Gene Therapies; Boston University School of Medicine; Ragon Institute of MGH, MIT, and Harvard; and others
Keywords: SARS-CoV-2, AAV-vaccine candidates, immune response, mice, primates
Summary of Study: Studies of the AAV-based vaccine candidate AC1 support its potential to protect from COVID-19 disease and infection from a single-dose immunization; may lead to highly durable immunogenicity; and is stable at ambient temperature for storage for several weeks. The combination of these WHO-specific key attributes have not been met by any of the currently approved vaccines. Continued development of second-generation vaccine candidates such at AC1 is needed.
References: PMID: 34428428 / doi: 10.1016/j.chom.2021.08.002
Contact Info: Roger LeGrand: [email protected]; Luk Vandenberghe: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1931312821003784?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Universite paris-Saclay/Inserm/Cea; Pereman School of Medicine; Novartis Gene Therapies; Boston University School of Medicine; Ragon Institute of MGH, MIT, and Harvard; and others
Keywords: SARS-CoV-2, AAV-vaccine candidates, immune response, mice, primates
Summary of Study: Studies of the AAV-based vaccine candidate AC1 support its potential to protect from COVID-19 disease and infection from a single-dose immunization; may lead to highly durable immunogenicity; and is stable at ambient temperature for storage for several weeks. The combination of these WHO-specific key attributes have not been met by any of the currently approved vaccines. Continued development of second-generation vaccine candidates such at AC1 is needed.
References: PMID: 34428428 / doi: 10.1016/j.chom.2021.08.002
Contact Info: Roger LeGrand: [email protected]; Luk Vandenberghe: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1931312821003784?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID, Ragon Institute of MGH, MIT< and Harvard, University of Duisburg-Essen, Harvard University, Emory Vaccine Center, Yerkes National Primate Research Center, and others
Keywords: SARS-CoV-2, protein subunit vaccine, soluble prefusion-stabilized spike trimers, immune response, primates
Summary of Study: Soluble prefusion-stablized spike protein trimers (preS DTM) from SARS-CoV-2 were formulated with the adjuvant AS03 and administered twice to NHPs. Two days after challenge, vaccinated NHPs showed rapid control of viral replication in both the upper and lower airways. These data indicate that antibodies induced by the AS03-adjuvanted preS dTM vaccine were sufficient to mediate protection against SARS-CoV-2 in NHPs and that rapid anamnestic antibody responses in the lung may be a key mechanism for protection.
References: PMID: 34315825 / doi: 10.1126/scitranslmed.abi4547
Contact Info: Robert Seder: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abi4547?url_ver=Z39.88-2003&rf…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID, Ragon Institute of MGH, MIT< and Harvard, University of Duisburg-Essen, Harvard University, Emory Vaccine Center, Yerkes National Primate Research Center, and others
Keywords: SARS-CoV-2, protein subunit vaccine, soluble prefusion-stabilized spike trimers, immune response, primates
Summary of Study: Soluble prefusion-stablized spike protein trimers (preS DTM) from SARS-CoV-2 were formulated with the adjuvant AS03 and administered twice to NHPs. Two days after challenge, vaccinated NHPs showed rapid control of viral replication in both the upper and lower airways. These data indicate that antibodies induced by the AS03-adjuvanted preS dTM vaccine were sufficient to mediate protection against SARS-CoV-2 in NHPs and that rapid anamnestic antibody responses in the lung may be a key mechanism for protection.
References: PMID: 34315825 / doi: 10.1126/scitranslmed.abi4547
Contact Info: Robert Seder: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abi4547?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: The Catholic University of Korea, Korea Research Institute of Bioscience and Biotechnology, SK Science, Jeonbuk National University, and others
Keywords: SARS-CoV-2, receptor-binding domain of SARS-CoV-2, immune response, mice and primates
Summary of Study: RBD-P2 + alum immunization elicits a robust neutralizing antibody response and provides complete or near-complete elimination of live SARS-CoV-2 virus particles. Additionally, findings provide insight into the potential use of the N protein in the development of SARS-CoV-2 vaccines.
References: PMID: 34049881 / doi: 10.1126/sciadv.abg7156
Contact Info: Jae-Hwan Nam: [email protected]; Sang-Myeong Lee: [email protected]; Jung Joo Hong: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.abg7156?url_ver=Z39.88-2003&rfr_id=o…
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: The Catholic University of Korea, Korea Research Institute of Bioscience and Biotechnology, SK Science, Jeonbuk National University, and others
Keywords: SARS-CoV-2, receptor-binding domain of SARS-CoV-2, immune response, mice and primates
Summary of Study: RBD-P2 + alum immunization elicits a robust neutralizing antibody response and provides complete or near-complete elimination of live SARS-CoV-2 virus particles. Additionally, findings provide insight into the potential use of the N protein in the development of SARS-CoV-2 vaccines.
References: PMID: 34049881 / doi: 10.1126/sciadv.abg7156
Contact Info: Jae-Hwan Nam: [email protected]; Sang-Myeong Lee: [email protected]; Jung Joo Hong: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.abg7156?url_ver=Z39.88-2003&rfr_id=o…
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine; Tulane National Primate Research Center; SE LA Veterans Affairs Healthcare System, and others
Keywords: SARS-CoV-2, severe acute respiratory syndrome and diabetes, chronic pancreatic dysfunction, primates
Summary of Study: SARS-CoV-2 infects pancreatic islet, ductal, and endothelial cells in male and female NHPs and humans with COVID-19. The long-term consequences of a fibrotic/thrombotic pancreas, such as chronic pancreatic exocrine dysfunction and late-onset diabetes, should be investigated as postacute sequelae of COVID-19.
References: PMID: 34241597 / doi: 10.1172/jci.insight.151551
Contact Info: Mirza Muhammad Fahd Qadir: [email protected]; Rudolf Bohm: [email protected]
URL: https://insight.jci.org/articles/view/151551
NHP Species: african green monkeys, rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine; Tulane National Primate Research Center; SE LA Veterans Affairs Healthcare System, and others
Keywords: SARS-CoV-2, severe acute respiratory syndrome and diabetes, chronic pancreatic dysfunction, primates
Summary of Study: SARS-CoV-2 infects pancreatic islet, ductal, and endothelial cells in male and female NHPs and humans with COVID-19. The long-term consequences of a fibrotic/thrombotic pancreas, such as chronic pancreatic exocrine dysfunction and late-onset diabetes, should be investigated as postacute sequelae of COVID-19.
References: PMID: 34241597 / doi: 10.1172/jci.insight.151551
Contact Info: Mirza Muhammad Fahd Qadir: [email protected]; Rudolf Bohm: [email protected]
URL: https://insight.jci.org/articles/view/151551
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: YishengBio Co., Ltd.; Chinese Academy of Sciences; National Health Commission of the People's Republic of China
Keywords: SARS-CoV-2, S-trimer, PIKA, vaccine, virus genomic variants, primates
Summary of Study: In this study of non-human primates, PIKA adjuvanted S-trimer induced high SARS-CoV-2 neutralization titers and protected from virus replication in the lung following SARS-CoV-2 challenge.
References: PMID: 34766005 / doi: 10.1186/s43556-021-00054-z
Contact Info: Yi Zhang: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475395/
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: YishengBio Co., Ltd.; Chinese Academy of Sciences; National Health Commission of the People's Republic of China
Keywords: SARS-CoV-2, S-trimer, PIKA, vaccine, virus genomic variants, primates
Summary of Study: In this study of non-human primates, PIKA adjuvanted S-trimer induced high SARS-CoV-2 neutralization titers and protected from virus replication in the lung following SARS-CoV-2 challenge.
References: PMID: 34766005 / doi: 10.1186/s43556-021-00054-z
Contact Info: Yi Zhang: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475395/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Nagoya University; Kyushu University; Akita University Graduate School of Medicine; and others
Keywords: SARS-CoV-2, mathematical model, infection dynamics, kinetics of viral shedding, primates
Summary of Study: The authors used a simple mathematical model to quantify SARS-CoV-2 infection dynamics in rhesus macaques. When antiviral treatments are initiated early (i.e. 0.5 d after virus inoculation), viral shedding is (paradoxically) prolonged by about 6.0 days compared with no treatment.
References: PMID: 34344719 / doi: 10.26508/lsa.202101049
Contact Info: Keisuke Ejima: [email protected]; Shingo Iwami: [email protected]
URL: https://www.life-science-alliance.org/content/4/10/e202101049
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Nagoya University; Kyushu University; Akita University Graduate School of Medicine; and others
Keywords: SARS-CoV-2, mathematical model, infection dynamics, kinetics of viral shedding, primates
Summary of Study: The authors used a simple mathematical model to quantify SARS-CoV-2 infection dynamics in rhesus macaques. When antiviral treatments are initiated early (i.e. 0.5 d after virus inoculation), viral shedding is (paradoxically) prolonged by about 6.0 days compared with no treatment.
References: PMID: 34344719 / doi: 10.26508/lsa.202101049
Contact Info: Keisuke Ejima: [email protected]; Shingo Iwami: [email protected]
URL: https://www.life-science-alliance.org/content/4/10/e202101049
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Sanofi Pasteur, Yoh Services, Global Discovery Pathology, Translate Bio
Keywords: SARS-CoV-2, multiple animal species, mRNA vaccine, immune response, pathology, primates
Summary of Study: Several mRNA vaccine candidates were assessed; the lead 2P/GSAS vaccine formulation (designated MRT550) elicited potent nAbs as well as TH1-biased responses in NHPs, thus alleviating a hypothetical concern of potential vaccine-associated enhanced respiratory diseases known associated with TH2-biased responses. These data position MRT5500 as a viable vaccine candidate for entering clinical development.
References: PMID: 33875658 / doi: 10.1038/s41541-021-00324-5
Contact Info: Kirill Kalnin: [email protected]
URL: https://www.nature.com/articles/s41541-021-00324-5
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Sanofi Pasteur, Yoh Services, Global Discovery Pathology, Translate Bio
Keywords: SARS-CoV-2, multiple animal species, mRNA vaccine, immune response, pathology, primates
Summary of Study: Several mRNA vaccine candidates were assessed; the lead 2P/GSAS vaccine formulation (designated MRT550) elicited potent nAbs as well as TH1-biased responses in NHPs, thus alleviating a hypothetical concern of potential vaccine-associated enhanced respiratory diseases known associated with TH2-biased responses. These data position MRT5500 as a viable vaccine candidate for entering clinical development.
References: PMID: 33875658 / doi: 10.1038/s41541-021-00324-5
Contact Info: Kirill Kalnin: [email protected]
URL: https://www.nature.com/articles/s41541-021-00324-5
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Science, Trinomab Biotech Co.
Keywords: SARS-CoV-2, ferritin nanoparticles, receptor-binding domain of SARS-CoV-2, immune response, primates
Summary of Study: Self-assembling nanoparticle vaccines displaying the RBD of SARS-CoV-2 were prepared, and the vaccine candidate elicited robust humoral and T cell responses and protected the rhesus monkeys from infection with short-term shedding and only minor pathological damage.
References: PMID: 33951913 / doi: 10.1021/acs.bioconjchem.1c00208
Contact Info: Longding Liu: [email protected]; Qihan Li: [email protected]; Zhanlong He: [email protected]
URL: https://pubs.acs.org/doi/10.1021/acs.bioconjchem.1c00208
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Science, Trinomab Biotech Co.
Keywords: SARS-CoV-2, ferritin nanoparticles, receptor-binding domain of SARS-CoV-2, immune response, primates
Summary of Study: Self-assembling nanoparticle vaccines displaying the RBD of SARS-CoV-2 were prepared, and the vaccine candidate elicited robust humoral and T cell responses and protected the rhesus monkeys from infection with short-term shedding and only minor pathological damage.
References: PMID: 33951913 / doi: 10.1021/acs.bioconjchem.1c00208
Contact Info: Longding Liu: [email protected]; Qihan Li: [email protected]; Zhanlong He: [email protected]
URL: https://pubs.acs.org/doi/10.1021/acs.bioconjchem.1c00208
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Dalhousie University; University of Calgary
Keywords: SARS-CoV-2, anthropozoonosis, virus transmission between the animal species, primates
Summary of Study: While the risk of transmission of SARS-CoV-2 via wastewater is low, tracing of viral RNA in wastewater does provide a unique testing approach to help protect NHPs at zoos and wildlife sanctuaries.
References: PMID: 34662463 / doi: 10.1002/ajp.23340
Contact Info: Graham Dellaire: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/ajp.23340
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Dalhousie University; University of Calgary
Keywords: SARS-CoV-2, anthropozoonosis, virus transmission between the animal species, primates
Summary of Study: While the risk of transmission of SARS-CoV-2 via wastewater is low, tracing of viral RNA in wastewater does provide a unique testing approach to help protect NHPs at zoos and wildlife sanctuaries.
References: PMID: 34662463 / doi: 10.1002/ajp.23340
Contact Info: Graham Dellaire: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/ajp.23340
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Perelman School of Medicine (UPenn)
Keywords: SARS-CoV-2, clinical and pathologic consequences, ACE2 decoy protein, primates
Summary of Study: The ACE2 decoy (soluble forms of angiotensin-converting enzyme 2) gene therapy approach could be effectively deployed to vulnerable populations in the COVID-19 pandemic and potentially to broader populations at the outset of future coronavirus pandemics.
References: PMID: 34265018 / doi: 10.1371/journal.ppat.1009544
Contact Info: James Wilson: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009544
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Perelman School of Medicine (UPenn)
Keywords: SARS-CoV-2, clinical and pathologic consequences, ACE2 decoy protein, primates
Summary of Study: The ACE2 decoy (soluble forms of angiotensin-converting enzyme 2) gene therapy approach could be effectively deployed to vulnerable populations in the COVID-19 pandemic and potentially to broader populations at the outset of future coronavirus pandemics.
References: PMID: 34265018 / doi: 10.1371/journal.ppat.1009544
Contact Info: James Wilson: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009544
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Washington Univ SOM, NIAID
Keywords: SARS-CoV-2, adenovirus-vectored vaccine, immunogenicity and protective efficacy, primates
Summary of Study: A single intranasal dose of ChAd-SARS-CoV-2-S induces neutralizing antibodies and T cell responses and limits or prevents infection in the upper and lower respiratory tracts after SARS-CoV-2 challenge in rhesus macaques.
References: PMID: 33754147 / doi: 10.1016/j.xcrm.2021.100230
Contact Info: Heinz Feldmann: [email protected]; Michael Diamond: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S266637912100046X?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Washington Univ SOM, NIAID
Keywords: SARS-CoV-2, adenovirus-vectored vaccine, immunogenicity and protective efficacy, primates
Summary of Study: A single intranasal dose of ChAd-SARS-CoV-2-S induces neutralizing antibodies and T cell responses and limits or prevents infection in the upper and lower respiratory tracts after SARS-CoV-2 challenge in rhesus macaques.
References: PMID: 33754147 / doi: 10.1016/j.xcrm.2021.100230
Contact Info: Heinz Feldmann: [email protected]; Michael Diamond: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S266637912100046X?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; CureVac AG
Keywords: SARS-CoV-2, mRNA-vaccine, spike protein, humoral and cellular immune responses, primates
Summary of Study: Prime-boost vaccination with 4 ug of vaccine candidate CV07050101 resulted in limited immune responses in four out of six non-human primates.
References: PMID: 34452509 / doi: 10.3390/v13081645
Contact Info: Vincent Munster: [email protected]
URL: https://www.mdpi.com/1999-4915/13/8/1645
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; CureVac AG
Keywords: SARS-CoV-2, mRNA-vaccine, spike protein, humoral and cellular immune responses, primates
Summary of Study: Prime-boost vaccination with 4 ug of vaccine candidate CV07050101 resulted in limited immune responses in four out of six non-human primates.
References: PMID: 34452509 / doi: 10.3390/v13081645
Contact Info: Vincent Munster: [email protected]
URL: https://www.mdpi.com/1999-4915/13/8/1645
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIH
Keywords: SARS-CoV-2, single-cell RNA sequencing, lung cells, primates
Summary of Study: Monocyte-derived macrophages recruited to the lungs, rather than tissue-resident alveolar macrophages, were most likely to be responsible for phagocytosis of infected cells and cellular debris early in infection, with their roles switching during clearance of infection.
References: PMID: 33431511 / doi: 10.1126/scitranslmed.abe8146
Contact Info: Emmie DeWit: [email protected]
URL: https://stm.sciencemag.org/content/13/578/eabe8146.short
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIH
Keywords: SARS-CoV-2, single-cell RNA sequencing, lung cells, primates
Summary of Study: Monocyte-derived macrophages recruited to the lungs, rather than tissue-resident alveolar macrophages, were most likely to be responsible for phagocytosis of infected cells and cellular debris early in infection, with their roles switching during clearance of infection.
References: PMID: 33431511 / doi: 10.1126/scitranslmed.abe8146
Contact Info: Emmie DeWit: [email protected]
URL: https://stm.sciencemag.org/content/13/578/eabe8146.short
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: NCR Biotech Science Cluster; Indian Institute of Technology Kharagpur; Krishi Vigyan Kendra; Inter University Centre for Biomedical Research and Super Speciality Hospital
Keywords: SARS-CoV-2, zoonotic diseases, one health approach, multiple species, primates
Summary of Study: This review examines the different natural and experimentally induced cases of human to animal SARS-CoV-2 infection (reverse zoonosis).
References: PMID: 34903944 / doi: 10.14202/vetworld.2021.2817-2826
Contact Info: R. Kumar Pramod: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654767/pdf/Vetworld-14-2817.pdf
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: NCR Biotech Science Cluster; Indian Institute of Technology Kharagpur; Krishi Vigyan Kendra; Inter University Centre for Biomedical Research and Super Speciality Hospital
Keywords: SARS-CoV-2, zoonotic diseases, one health approach, multiple species, primates
Summary of Study: This review examines the different natural and experimentally induced cases of human to animal SARS-CoV-2 infection (reverse zoonosis).
References: PMID: 34903944 / doi: 10.14202/vetworld.2021.2817-2826
Contact Info: R. Kumar Pramod: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654767/pdf/Vetworld-14-2817.pdf
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Henry M. Jackson Foundation for the Advancement of Military Medicine; Washington University; NCI/NIH; BIOQUAL; Texas Biomedical Research Institute; Columbia University Vagelos College of Physicians and Surgeons.
Keywords: SARS-CoV-2, nanoparticle protein vaccine, humoral and cellular immune responses, virus variants, primates
Summary of Study: A ferritin nanoparticle vaccine displaying the receptor-binding domain of the SARS-CoV-2 spike protein adjuvanted with Army Liposomal Formulation QS-21 induces robust and broad antibody and T cell responses, as well as protection against viral replication and lung pathology following high-dose respiratory tract challenge with SARS-CoV-2.
References: PMID: 34470866 / doi: 10.1073/pnas.2106433118
Contact Info: Kayvon Modjarrad: [email protected]; Diane Bolton: [email protected]
URL: https://www.pnas.org/content/118/38/e2106433118.long
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Henry M. Jackson Foundation for the Advancement of Military Medicine; Washington University; NCI/NIH; BIOQUAL; Texas Biomedical Research Institute; Columbia University Vagelos College of Physicians and Surgeons.
Keywords: SARS-CoV-2, nanoparticle protein vaccine, humoral and cellular immune responses, virus variants, primates
Summary of Study: A ferritin nanoparticle vaccine displaying the receptor-binding domain of the SARS-CoV-2 spike protein adjuvanted with Army Liposomal Formulation QS-21 induces robust and broad antibody and T cell responses, as well as protection against viral replication and lung pathology following high-dose respiratory tract challenge with SARS-CoV-2.
References: PMID: 34470866 / doi: 10.1073/pnas.2106433118
Contact Info: Kayvon Modjarrad: [email protected]; Diane Bolton: [email protected]
URL: https://www.pnas.org/content/118/38/e2106433118.long
Coronavirus Investigated: SARS-CoV-2
NHP Species: macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Institute for Basic Science (IBS) (Republic of Kores), Eulji University School of Medicine, Seol National University Hospital, Jeonbuk National University Medical School, Sungkyunkwan University School of Medicine
Keywords: SARS-CoV-2, nasal ciliated cells, virus tropism, primates
Summary of Study: Nasal multiciliated epithelial cells are the main target for SARS-CoV-2 infection and replication in the upper airway during the early stages of COVID-19, implying that targeting nasal ciliated cells could be an ideal strategy to prevent SARS-CoV-2 propagation.
References: PMID: 34003804 / doi: 10.1172/JCI148517
Contact Info: Ji Hoon Ahn: [email protected]; JungMo Kim: [email protected]; Seon Pyo Hong: [email protected]; Young Tae Kim: [email protected], Chang-Seop Lee: [email protected]
URL: https://www.jci.org/articles/view/148517
NHP Species: macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Institute for Basic Science (IBS) (Republic of Kores), Eulji University School of Medicine, Seol National University Hospital, Jeonbuk National University Medical School, Sungkyunkwan University School of Medicine
Keywords: SARS-CoV-2, nasal ciliated cells, virus tropism, primates
Summary of Study: Nasal multiciliated epithelial cells are the main target for SARS-CoV-2 infection and replication in the upper airway during the early stages of COVID-19, implying that targeting nasal ciliated cells could be an ideal strategy to prevent SARS-CoV-2 propagation.
References: PMID: 34003804 / doi: 10.1172/JCI148517
Contact Info: Ji Hoon Ahn: [email protected]; JungMo Kim: [email protected]; Seon Pyo Hong: [email protected]; Young Tae Kim: [email protected], Chang-Seop Lee: [email protected]
URL: https://www.jci.org/articles/view/148517
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Universite Paris-Saclay/Inserm/CEA; Vaccine Research INstitute, Creteil, France; Inserm; Baylor Scott and White Research Institute; Institut Pasteur; Karolinska Institutet; and others
Keywords: SARS-CoV-2, subunit vaccine, receptor-binding domain, immune response, humanized mice, primates
Summary of Study: A single dose of the alphaCD40.RBD (a vaccine that targets the receptor-binding domain of the SARS-CoV-2 spike antigen to the CD40 receptor) administered without adjuvant boosts the protective response in COVID-10 convalescent NHPs.
References: PMID: 34471122 / doi: 10.1038/s41467-021-25382-0
Contact Info: Yves Levy: [email protected]
URL: https://www.nature.com/articles/s41467-021-25382-0
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Universite Paris-Saclay/Inserm/CEA; Vaccine Research INstitute, Creteil, France; Inserm; Baylor Scott and White Research Institute; Institut Pasteur; Karolinska Institutet; and others
Keywords: SARS-CoV-2, subunit vaccine, receptor-binding domain, immune response, humanized mice, primates
Summary of Study: A single dose of the alphaCD40.RBD (a vaccine that targets the receptor-binding domain of the SARS-CoV-2 spike antigen to the CD40 receptor) administered without adjuvant boosts the protective response in COVID-10 convalescent NHPs.
References: PMID: 34471122 / doi: 10.1038/s41467-021-25382-0
Contact Info: Yves Levy: [email protected]
URL: https://www.nature.com/articles/s41467-021-25382-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School, University of North Carolina at Chapel Hill, Ragon Institute of MGH, MIT, and Harvard, Massachusetts Consortium on Pathogen Readiness
Keywords: SARS-CoV-2, adenovirus vaccine, immunogenicity and protective efficacy, mice
Summary of Study: RhAd52 vaccines elicit robust SARS-CoV-2 specific antibody responses and protect against clinical disease and viral replication in the lungs. These data validate the MA10 mouse model as a useful tool to screen and study novel vaccine candidates, as well as the development of RhAd52 vaccines for COVID-19.
References: PMID: 34523968 / doi: 10.1128/JVI.00974-21
Contact Info: Dan Barouch: [email protected]
URL: https://journals.asm.org/doi/10.1128/JVI.00974-21?url_ver=Z39.88-2003&rfr_id=or…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School, University of North Carolina at Chapel Hill, Ragon Institute of MGH, MIT, and Harvard, Massachusetts Consortium on Pathogen Readiness
Keywords: SARS-CoV-2, adenovirus vaccine, immunogenicity and protective efficacy, mice
Summary of Study: RhAd52 vaccines elicit robust SARS-CoV-2 specific antibody responses and protect against clinical disease and viral replication in the lungs. These data validate the MA10 mouse model as a useful tool to screen and study novel vaccine candidates, as well as the development of RhAd52 vaccines for COVID-19.
References: PMID: 34523968 / doi: 10.1128/JVI.00974-21
Contact Info: Dan Barouch: [email protected]
URL: https://journals.asm.org/doi/10.1128/JVI.00974-21?url_ver=Z39.88-2003&rfr_id=or…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Wisconsin National Primate Research Center, Harvard Medical School, Tufts University, BIOQUAL, Ragon Institute of MGH, MIT and Harvard
Keywords: SARS-CoV-2, prior infection, vaccination, virus variants, protection, hamsters, primates
Summary of Study: Data suggest partial but reduced short-term protective efficacy of WA1/2020 natural immunity against SARS-CoV-2 variants of concern. More research is needed to define protective efficacy against other SARS-CoV-2 variants and the immunologic mechanisms of protection against these variants.
References: PMID: 34546094 / doi: 10.1126/scitranslmed.abj2641
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abj2641?url_ver=Z39.88-2003&rf…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Wisconsin National Primate Research Center, Harvard Medical School, Tufts University, BIOQUAL, Ragon Institute of MGH, MIT and Harvard
Keywords: SARS-CoV-2, prior infection, vaccination, virus variants, protection, hamsters, primates
Summary of Study: Data suggest partial but reduced short-term protective efficacy of WA1/2020 natural immunity against SARS-CoV-2 variants of concern. More research is needed to define protective efficacy against other SARS-CoV-2 variants and the immunologic mechanisms of protection against these variants.
References: PMID: 34546094 / doi: 10.1126/scitranslmed.abj2641
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abj2641?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Battelle National Biodefense Institute; Gryphon Scientific LLC; Censeo Insight; Applied Research Associates
Keywords: SARS-CoV-2, inhalation, seroconversion, fever, dose response, primates
Summary of Study: SARS-CoV-2 infection and subsequent disease presentation are dependent on exposure dose in a nonhuman primate model of inhalational COVID-19.
References: PMID: 34424943 / doi: 10.1371/journal.ppat.1009865
Contact Info: Paul Dabisch: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009865
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Battelle National Biodefense Institute; Gryphon Scientific LLC; Censeo Insight; Applied Research Associates
Keywords: SARS-CoV-2, inhalation, seroconversion, fever, dose response, primates
Summary of Study: SARS-CoV-2 infection and subsequent disease presentation are dependent on exposure dose in a nonhuman primate model of inhalational COVID-19.
References: PMID: 34424943 / doi: 10.1371/journal.ppat.1009865
Contact Info: Paul Dabisch: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009865
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: VaxiGen, Inc., Genexine, Inc., Korea National Primate Research Centre, and others
Keywords: SARS-CoV-2, DNA-based vaccine, mice and primates, immune response
Summary of Study: A synthetic soluble SARS-CoV-2 spike (S) DNA-based vaccine candidate, GX-19, provides a durable protective immune response in rhesus macaques, supporting further development of GX-19 as a vaccine candidate for SARS-CoV-2.
References: PMID: 33804981 / doi: 10.3390/vaccines9040307
Contact Info: Yong Bok Seo: [email protected]; You Suk Suh: [email protected]; Jung Joo Hong: [email protected]
URL: https://www.mdpi.com/2076-393X/9/4/307
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: VaxiGen, Inc., Genexine, Inc., Korea National Primate Research Centre, and others
Keywords: SARS-CoV-2, DNA-based vaccine, mice and primates, immune response
Summary of Study: A synthetic soluble SARS-CoV-2 spike (S) DNA-based vaccine candidate, GX-19, provides a durable protective immune response in rhesus macaques, supporting further development of GX-19 as a vaccine candidate for SARS-CoV-2.
References: PMID: 33804981 / doi: 10.3390/vaccines9040307
Contact Info: Yong Bok Seo: [email protected]; You Suk Suh: [email protected]; Jung Joo Hong: [email protected]
URL: https://www.mdpi.com/2076-393X/9/4/307
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Univ. of Pennsylvania Perelman School of Medicine
Keywords: SARS-CoV-2, D614G Spike Mutation, Vaccinated and immune sera, neutralization, primates
Summary of Study: Vaccinated NHPs using the nucleoside-modified mRNA-LNP vaccine platform encoding four differentSARS-CoV-2 spike immunogens generate antibody responses that not only recognize the G614 mutation that has taken over the pandemic, but also have stronger titers of neutralization to this virus variant.
References: PMID: 33306985/doi: 10.1016/j.chom.2020.11.012
Contact Info: Drew Weissman (no contact information)
URL: https://www.sciencedirect.com/science/article/pii/S193131282030634X?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Univ. of Pennsylvania Perelman School of Medicine
Keywords: SARS-CoV-2, D614G Spike Mutation, Vaccinated and immune sera, neutralization, primates
Summary of Study: Vaccinated NHPs using the nucleoside-modified mRNA-LNP vaccine platform encoding four differentSARS-CoV-2 spike immunogens generate antibody responses that not only recognize the G614 mutation that has taken over the pandemic, but also have stronger titers of neutralization to this virus variant.
References: PMID: 33306985/doi: 10.1016/j.chom.2020.11.012
Contact Info: Drew Weissman (no contact information)
URL: https://www.sciencedirect.com/science/article/pii/S193131282030634X?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, inactivated vaccines, antibody-dependent enhancement, immunopathology, primates
Summary of Study: Results show that in the absence of cellular immunity, passive infusion of subneutralizing or nonneutralizing anti-SARS-CoV-2 antibodies could still provide some level of protection against infection upon challenge, and no low-level antibody-enhanced infection was observed.
References: PMID: 34736354 / doi: 10.1080/22221751.2021.2002670
Contact Info: Qihan Li: [email protected]; Longding Liu: [email protected]; Cunbao Liu: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2002670
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, inactivated vaccines, antibody-dependent enhancement, immunopathology, primates
Summary of Study: Results show that in the absence of cellular immunity, passive infusion of subneutralizing or nonneutralizing anti-SARS-CoV-2 antibodies could still provide some level of protection against infection upon challenge, and no low-level antibody-enhanced infection was observed.
References: PMID: 34736354 / doi: 10.1080/22221751.2021.2002670
Contact Info: Qihan Li: [email protected]; Longding Liu: [email protected]; Cunbao Liu: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2002670
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Beijing DanXu Biopharmaceuticals
Keywords: SARS-CoV-2, monoclonal antibody, ELISA assay, pharmacokinetic, primates
Summary of Study: In cynomolgus monkeys, BD-604 (a fully human monoclonal antibody) possesses pharmacokinetic properties similar to natural IgGs.
References: PMID: 34215019 / doi: 10.1002/dta.3122
Contact Info: Xu Zhang: [email protected]
URL: https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/dta.3122
NHP Species:
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Beijing DanXu Biopharmaceuticals
Keywords: SARS-CoV-2, monoclonal antibody, ELISA assay, pharmacokinetic, primates
Summary of Study: In cynomolgus monkeys, BD-604 (a fully human monoclonal antibody) possesses pharmacokinetic properties similar to natural IgGs.
References: PMID: 34215019 / doi: 10.1002/dta.3122
Contact Info: Xu Zhang: [email protected]
URL: https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/dta.3122
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences
Keywords: SARS-CoV-2, combined intratracheal and intranasal inoculation, primates
Summary of Study: The severity of respiratory tract infection enhanced air transmission and induced wide and severe SARS-CoV-2 infection in the lungs, suggesting the occurrence of more severe infectiousness and lung injury in SARS-CoV-2 patients with nasal infection.
References: PMID: 33587263 / doi: 10.1007/s11427-020-1877-4
Contact Info: Yong-Tang Zheng: [email protected]
URL: https://link.springer.com/article/10.1007%2Fs11427-020-1877-4
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences
Keywords: SARS-CoV-2, combined intratracheal and intranasal inoculation, primates
Summary of Study: The severity of respiratory tract infection enhanced air transmission and induced wide and severe SARS-CoV-2 infection in the lungs, suggesting the occurrence of more severe infectiousness and lung injury in SARS-CoV-2 patients with nasal infection.
References: PMID: 33587263 / doi: 10.1007/s11427-020-1877-4
Contact Info: Yong-Tang Zheng: [email protected]
URL: https://link.springer.com/article/10.1007%2Fs11427-020-1877-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Florida State University; University of Texas Medical Branch; Perelman School of Medicine; Duke University Medical Center; Johns Hopkins School of Medicine
Keywords: SARS-CoV-2, respiratory viral challenge, immune response, pathology, primates
Summary of Study: Data demonstrate that SARS-CoV-2 infection of pigtail macaques recapitulates important features of COVID-19 and reveals new immune and viral dynamics and thus may serve as a useful animal model for studying pathogenesis and testing vaccines and therapeutics.
References: PMID: 34929014 / doi: 10.1371/journal.ppat.1010162
Contact Info: Nicholas Maness: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010162
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Florida State University; University of Texas Medical Branch; Perelman School of Medicine; Duke University Medical Center; Johns Hopkins School of Medicine
Keywords: SARS-CoV-2, respiratory viral challenge, immune response, pathology, primates
Summary of Study: Data demonstrate that SARS-CoV-2 infection of pigtail macaques recapitulates important features of COVID-19 and reveals new immune and viral dynamics and thus may serve as a useful animal model for studying pathogenesis and testing vaccines and therapeutics.
References: PMID: 34929014 / doi: 10.1371/journal.ppat.1010162
Contact Info: Nicholas Maness: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010162
Coronavirus Investigated: SARS-CoV-2
NHP Species: tamarins, marmosets, howler monkeys, titi monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Faculdade de Medicina de Sao Jose do Rio Preto, Brazil; Fundacao de Medicina Tropical Doutor Heitor Vieria Dourado, Brazil; Universidade do Estado do Amazonas, Brazil; Universidade Federal do Amazonas, Brazil; Universidade de Sao Paulo, Brazil; Hospital Israelita Albert Einstein; Instituto Butanta; Departamento de Vigilancia Epidemiologica de Sao Jose do Rio Preto; New Mexico State University; The University of Texas Medical Branch, Galveston; Instituto Leonidas e Maria Deane, Brazil
Keywords: SARS-CoV-2, wild animals, molecular and serological tests, primates
Summary of Study: Although no evidence of SARS-CoV-2 infection was detected, continued surveillance of NHPs in this region is warranted and may identify geographic areas or particular NHP species prone to spillover.
References: PMID: 34696363 / doi: 10.3390/v13101933
Contact Info: Marcus Vinicius Guimaraes de Lacerda: [email protected]; Mauricio Lacerda Nogueira: [email protected]
URL: https://www.mdpi.com/1999-4915/13/10/1933
NHP Species: tamarins, marmosets, howler monkeys, titi monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Faculdade de Medicina de Sao Jose do Rio Preto, Brazil; Fundacao de Medicina Tropical Doutor Heitor Vieria Dourado, Brazil; Universidade do Estado do Amazonas, Brazil; Universidade Federal do Amazonas, Brazil; Universidade de Sao Paulo, Brazil; Hospital Israelita Albert Einstein; Instituto Butanta; Departamento de Vigilancia Epidemiologica de Sao Jose do Rio Preto; New Mexico State University; The University of Texas Medical Branch, Galveston; Instituto Leonidas e Maria Deane, Brazil
Keywords: SARS-CoV-2, wild animals, molecular and serological tests, primates
Summary of Study: Although no evidence of SARS-CoV-2 infection was detected, continued surveillance of NHPs in this region is warranted and may identify geographic areas or particular NHP species prone to spillover.
References: PMID: 34696363 / doi: 10.3390/v13101933
Contact Info: Marcus Vinicius Guimaraes de Lacerda: [email protected]; Mauricio Lacerda Nogueira: [email protected]
URL: https://www.mdpi.com/1999-4915/13/10/1933
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center, Tulane University School of Medicine, Tulane University, Brigham and Women's Hospital/Harvard Medical School, LSU Health Science Center, Julius-Maximilians-Universitat Wurzburg, and more
Keywords: SARS-CoV-2, pulmonary vascular endotheliosis, perivascular inflammation, rodents and primates
Summary of Study: SARS-CoV-2 causes endotheliitis via both infection and infection-mediated immune activation, which may contribute to the pathogenesis of severe COVID-19 disease.
References: PMID: 34335981 / doi: 10.7150/thno.61810
Contact Info: Jay Kolls: [email protected]; Fengming Liu: [email protected]; Jay Rappaport: [email protected]
URL: https://www.thno.org/v11p8076.htm
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center, Tulane University School of Medicine, Tulane University, Brigham and Women's Hospital/Harvard Medical School, LSU Health Science Center, Julius-Maximilians-Universitat Wurzburg, and more
Keywords: SARS-CoV-2, pulmonary vascular endotheliosis, perivascular inflammation, rodents and primates
Summary of Study: SARS-CoV-2 causes endotheliitis via both infection and infection-mediated immune activation, which may contribute to the pathogenesis of severe COVID-19 disease.
References: PMID: 34335981 / doi: 10.7150/thno.61810
Contact Info: Jay Kolls: [email protected]; Fengming Liu: [email protected]; Jay Rappaport: [email protected]
URL: https://www.thno.org/v11p8076.htm