Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: National Institute of Infectious Diseases, Japan; University of Tokyo; Kumamoto University, and others
Keywords: SARS-CoV-2, virus-specific CD8+ T-cell responses, virus replication, immune response, primates
Summary of Study: The effect of CD8+ cell depletion on SARS-CoV-2 replication when monoclonal anti-CD8 antibody is administered in the subacute phase was studied in cynomolgus macaques. Analysis revealed no significant impact of CD8+ cell depletion on viral replication, indicating the subacute SARS-CoV-2 replication can be controlled in the absence of CD8+ T cells.
References: PMID: 34280241 / doi: 10.1371/journal.ppat.1009668
Contact Info: Tetsuro Matano: [email protected]; Takushi Nomura: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009668
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: National Institute of Infectious Diseases, Japan; University of Tokyo; Kumamoto University, and others
Keywords: SARS-CoV-2, virus-specific CD8+ T-cell responses, virus replication, immune response, primates
Summary of Study: The effect of CD8+ cell depletion on SARS-CoV-2 replication when monoclonal anti-CD8 antibody is administered in the subacute phase was studied in cynomolgus macaques. Analysis revealed no significant impact of CD8+ cell depletion on viral replication, indicating the subacute SARS-CoV-2 replication can be controlled in the absence of CD8+ T cells.
References: PMID: 34280241 / doi: 10.1371/journal.ppat.1009668
Contact Info: Tetsuro Matano: [email protected]; Takushi Nomura: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009668
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences; Peking Union Medical College; Capital Medical University
Keywords: SARS-CoV-2, pathology, myocardial injury, differential expression, primates
Summary of Study: SARS-CoV-2 infected rhesus macaques showed viral myocarditis, where inflammation and endothelial injury jointly resulted in cardiac damage.
References: PMID: 34489396 / doi: 10.1038/s413392-021-00747-5
Contact Info: Jiangning Liu: [email protected]; Jing Wang: [email protected]
URL: https://www.nature.com/articles/s41392-021-00747-5
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences; Peking Union Medical College; Capital Medical University
Keywords: SARS-CoV-2, pathology, myocardial injury, differential expression, primates
Summary of Study: SARS-CoV-2 infected rhesus macaques showed viral myocarditis, where inflammation and endothelial injury jointly resulted in cardiac damage.
References: PMID: 34489396 / doi: 10.1038/s413392-021-00747-5
Contact Info: Jiangning Liu: [email protected]; Jing Wang: [email protected]
URL: https://www.nature.com/articles/s41392-021-00747-5
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Harvard Univ., MIT, Tulane National Primate Research Center
Keywords: SARS-CoV-2, respiratory droplet generation and exhalation, primates
Summary of Study: The proportion of small respiratory droplets (the majority of particles exhaled in all subjects) increased at the peak of COVID-19 infection in NHPs. This confirms a previously published observation from the exhaled aerosol profile of a single COVID-19 positive human subject, and suggests that, at peak infection, there may be an elevated risk of the airborne transmission of SARS-CoV-2 by way of the very small droplets that transmit through conventional masks and travers distances far exceeding the conventional social distance of 2 m.
References: PMID: 33563754 / doi: 10.1073/pnas.2021830118
Contact Info: David Edwards: [email protected]; Chad Roy: [email protected]
URL: https://www.pnas.org/content/118/8/e2021830118.long
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Harvard Univ., MIT, Tulane National Primate Research Center
Keywords: SARS-CoV-2, respiratory droplet generation and exhalation, primates
Summary of Study: The proportion of small respiratory droplets (the majority of particles exhaled in all subjects) increased at the peak of COVID-19 infection in NHPs. This confirms a previously published observation from the exhaled aerosol profile of a single COVID-19 positive human subject, and suggests that, at peak infection, there may be an elevated risk of the airborne transmission of SARS-CoV-2 by way of the very small droplets that transmit through conventional masks and travers distances far exceeding the conventional social distance of 2 m.
References: PMID: 33563754 / doi: 10.1073/pnas.2021830118
Contact Info: David Edwards: [email protected]; Chad Roy: [email protected]
URL: https://www.pnas.org/content/118/8/e2021830118.long
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Melbourne, Monash University
Keywords: SARS-CoV-2, prime-boost protein subunit vaccine, mice and primates
Summary of Study: Both S and RBD vaccines are comparably immunogenic and produced strong serological neutralizing responses in pig-tailed macaques. Overall, immunization with recombinant S immunogens reliably elicits potentially protective humoral immunity at levels in excess of those observed in convalescent human, confirming recombinant S proteins as promising vaccine candidates.
References: PMID: 33658497 / doi: 10.1038/s41467-021-21665-8
Contact Info: Stephen Kent: [email protected]
URL: https://www.nature.com/articles/s41467-021-21665-8
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Melbourne, Monash University
Keywords: SARS-CoV-2, prime-boost protein subunit vaccine, mice and primates
Summary of Study: Both S and RBD vaccines are comparably immunogenic and produced strong serological neutralizing responses in pig-tailed macaques. Overall, immunization with recombinant S immunogens reliably elicits potentially protective humoral immunity at levels in excess of those observed in convalescent human, confirming recombinant S proteins as promising vaccine candidates.
References: PMID: 33658497 / doi: 10.1038/s41467-021-21665-8
Contact Info: Stephen Kent: [email protected]
URL: https://www.nature.com/articles/s41467-021-21665-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Chinese Academy of Sciences; State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing; Sinocelltech Ltd., National Institutes for Food and Drug Control, Beijing; Institute for Biological Product Control, Beijing
Keywords: SARS-CoV-2, monoclonal antibody, preclinical safety evaluation, cryo-EM structure, mice, primates
Summary of Study: Increasing access to panels of authentic neutralizing monoclonal antibodies will facilitate structure-function studies to unpick the underlying biological processes of virus-host interactions, and provide molecular basis for applying HB27 for potential COVID-19 treatment.
References: PMID: 34676096 / doi: 10.1093/nsr/nwaa297
Contact Info: Cheng-Feng Qin: [email protected]; Xiangxi Wang: [email protected]; Youchun Wang: [email protected]; Zihe Rao: [email protected]; Liangzhi Xie: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798916/
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Chinese Academy of Sciences; State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing; Sinocelltech Ltd., National Institutes for Food and Drug Control, Beijing; Institute for Biological Product Control, Beijing
Keywords: SARS-CoV-2, monoclonal antibody, preclinical safety evaluation, cryo-EM structure, mice, primates
Summary of Study: Increasing access to panels of authentic neutralizing monoclonal antibodies will facilitate structure-function studies to unpick the underlying biological processes of virus-host interactions, and provide molecular basis for applying HB27 for potential COVID-19 treatment.
References: PMID: 34676096 / doi: 10.1093/nsr/nwaa297
Contact Info: Cheng-Feng Qin: [email protected]; Xiangxi Wang: [email protected]; Youchun Wang: [email protected]; Zihe Rao: [email protected]; Liangzhi Xie: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798916/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: California National Primate Research Center; University of California, Davis; Louisiana State University Health Sciences Center; The Rockefeller University.
Keywords: SARS-CoV-2, neuroinflammation, effector CD4 T cells, inflammation, cerebrospinal fluid, pneumonia, primates
Summary of Study: Neutralizing mABs administered preventatively to high-risk populations may mitigate the adverse inflammatory consequences of SARS-CoV-2 exposure.
References: PMID: 34706272 / doi: 10.1016/j.celrep.2021.109942
Contact Info: Smita Iyer: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2211124721014157?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: California National Primate Research Center; University of California, Davis; Louisiana State University Health Sciences Center; The Rockefeller University.
Keywords: SARS-CoV-2, neuroinflammation, effector CD4 T cells, inflammation, cerebrospinal fluid, pneumonia, primates
Summary of Study: Neutralizing mABs administered preventatively to high-risk populations may mitigate the adverse inflammatory consequences of SARS-CoV-2 exposure.
References: PMID: 34706272 / doi: 10.1016/j.celrep.2021.109942
Contact Info: Smita Iyer: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2211124721014157?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Wuhan Institute of Virology, Chinese Academy of Sciences; University of the Chinese Academy of Sciences; Wuhan YZY Biopharma Co., Ltd.
Keywords: SARS-CoV-2, subunit vaccine, immunity, virus load, pathology, primates
Summary of Study: The RBD-homodimer vaccine candidate studied can induce both humoral and cellular response in vivo and prevent SARS-CoV-2 infection in both rodents and non-human primates. Production of this RBD vaccine candidate can be performed in large scale, which will enhance the vaccine supply and warrants future clinical trials.
References: PMID: 34493710 / doi: 10.1038/s41421-021-00320-y
Contact Info: Zhiming Yuan: [email protected]; Chao Shan: [email protected]; Genfu Xiao: [email protected]
URL: https://www.nature.com/articles/s41421-021-00320-y
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Wuhan Institute of Virology, Chinese Academy of Sciences; University of the Chinese Academy of Sciences; Wuhan YZY Biopharma Co., Ltd.
Keywords: SARS-CoV-2, subunit vaccine, immunity, virus load, pathology, primates
Summary of Study: The RBD-homodimer vaccine candidate studied can induce both humoral and cellular response in vivo and prevent SARS-CoV-2 infection in both rodents and non-human primates. Production of this RBD vaccine candidate can be performed in large scale, which will enhance the vaccine supply and warrants future clinical trials.
References: PMID: 34493710 / doi: 10.1038/s41421-021-00320-y
Contact Info: Zhiming Yuan: [email protected]; Chao Shan: [email protected]; Genfu Xiao: [email protected]
URL: https://www.nature.com/articles/s41421-021-00320-y
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Korea Research Institute of Bioscience & Biotechnology, Chonnam National University, Chungbuk National University
Keywords: SARS-CoV-2, virus variants, microevolution, species specific variations, primates
Summary of Study: The genomes of SARS-CoV-2 differ according to individuals and species despite infection of the identical virus in NHPs. These results are important for the interpretation of longitudinal studies evaluating the evolution of the SARS-CoV-2 in humans and development of new diagnostics, vaccine, and therapeutics targeting SARS-CoV-2.
References: PMID: 34305860 / doi: 10.3389/fmicb.2021.694897
Contact Info: Jungjoo Hong: [email protected]; Bon-Sang Koo: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2021.694897/full
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Korea Research Institute of Bioscience & Biotechnology, Chonnam National University, Chungbuk National University
Keywords: SARS-CoV-2, virus variants, microevolution, species specific variations, primates
Summary of Study: The genomes of SARS-CoV-2 differ according to individuals and species despite infection of the identical virus in NHPs. These results are important for the interpretation of longitudinal studies evaluating the evolution of the SARS-CoV-2 in humans and development of new diagnostics, vaccine, and therapeutics targeting SARS-CoV-2.
References: PMID: 34305860 / doi: 10.3389/fmicb.2021.694897
Contact Info: Jungjoo Hong: [email protected]; Bon-Sang Koo: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2021.694897/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Laboratory of Virology, Hamilton, MT; NIAID; University of Plymouth, Plymouth, UK; The Vaccine Group, Ltd.
Keywords: SARS-CoV-2, virus genomic variants, pathology, virus replication, shedding, primates
Summary of Study: Results from the intranasal AGM COVID-19 surrogate model support the most recent data from B.1.1.7 in humans, providing direct empirical data for increased replication in the respiratory tissue, but with no enhancement of disease.
References: PMID: 34724885 / doi: 10.1080/22221751.2021.1997074
Contact Info: Heinz Feldmann: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1997074
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Laboratory of Virology, Hamilton, MT; NIAID; University of Plymouth, Plymouth, UK; The Vaccine Group, Ltd.
Keywords: SARS-CoV-2, virus genomic variants, pathology, virus replication, shedding, primates
Summary of Study: Results from the intranasal AGM COVID-19 surrogate model support the most recent data from B.1.1.7 in humans, providing direct empirical data for increased replication in the respiratory tissue, but with no enhancement of disease.
References: PMID: 34724885 / doi: 10.1080/22221751.2021.1997074
Contact Info: Heinz Feldmann: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1997074
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Amsterdam, Universite Paris-Saclay, University of Southampton, and others
Keywords: SARS-CoV-2, two-component protein nanoparticle vaccine, primates
Summary of Study: A two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein induces potent neutralizing antibody responses in cynomolgus macaques. The vaccine-induced immunity protects macaques against a high-dose challenge, resulting in strongly reduced viral infection and replication in the upper and lower airways. These nanoparticles are a promising vaccine candidate.
References: PMID: 33577765 / doi: 10.1016/j.cell.2021.01.035
Contact Info: Roger Le Grand: [email protected]; Rogier Sanders: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0092867421000787?via%3Dihub=
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Amsterdam, Universite Paris-Saclay, University of Southampton, and others
Keywords: SARS-CoV-2, two-component protein nanoparticle vaccine, primates
Summary of Study: A two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein induces potent neutralizing antibody responses in cynomolgus macaques. The vaccine-induced immunity protects macaques against a high-dose challenge, resulting in strongly reduced viral infection and replication in the upper and lower airways. These nanoparticles are a promising vaccine candidate.
References: PMID: 33577765 / doi: 10.1016/j.cell.2021.01.035
Contact Info: Roger Le Grand: [email protected]; Rogier Sanders: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0092867421000787?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Institute of Human Virology, Zhongshan School of Medicine
Keywords: SARS-CoV-2, convalescent sera, receptor-binding domain based nanoparticles, virus variants, primates
Summary of Study: Results show that as mutations accumulate in the RBD, spike proteins may acquire an antigenic shift that enable SARS-CoV-2 variants to eventually resist the current vaccines. Intensive monitoring of virus mutations and timely adjustment of the designed vaccines are required to control the viral pandemic.
References: PMID: 33580167 / doi: 10.1038/s41423-021-00641-8
Contact Info: Xin He: [email protected]
URL: https://www.nature.com/articles/s41423-021-00641-8
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Institute of Human Virology, Zhongshan School of Medicine
Keywords: SARS-CoV-2, convalescent sera, receptor-binding domain based nanoparticles, virus variants, primates
Summary of Study: Results show that as mutations accumulate in the RBD, spike proteins may acquire an antigenic shift that enable SARS-CoV-2 variants to eventually resist the current vaccines. Intensive monitoring of virus mutations and timely adjustment of the designed vaccines are required to control the viral pandemic.
References: PMID: 33580167 / doi: 10.1038/s41423-021-00641-8
Contact Info: Xin He: [email protected]
URL: https://www.nature.com/articles/s41423-021-00641-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: California National Primate Research Center, UC Davis
Keywords: SARS-CoV-2, CD4 T follicular helper (Tfh) cells, primates
Summary of Study: SARC-CoV-2 infection in rhesus macaques, either infused with convalescent plasma, normal plasma, or receiving no infusion showed induction of germinal center (GC) responses.
References: PMID: 33483492 / doi: 10.1038/s41467-020-20642-x
Contact Info: Koen Van Rompay: [email protected]; Smita Iyer: [email protected]
URL: https://www.nature.com/articles/s41467-020-20642-x
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: California National Primate Research Center, UC Davis
Keywords: SARS-CoV-2, CD4 T follicular helper (Tfh) cells, primates
Summary of Study: SARC-CoV-2 infection in rhesus macaques, either infused with convalescent plasma, normal plasma, or receiving no infusion showed induction of germinal center (GC) responses.
References: PMID: 33483492 / doi: 10.1038/s41467-020-20642-x
Contact Info: Koen Van Rompay: [email protected]; Smita Iyer: [email protected]
URL: https://www.nature.com/articles/s41467-020-20642-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Karolinska Institute, University of Cape Town
Keywords: SARS-CoV-2, spike protein subunit vaccine, mice and primates, immune response
Summary of Study: Adjuvanted protein immunization with soluble SARS-CoV-2 Spike trimers, stabilized in prefusion conformation, results in potent antibody responses in mice and rhesus macaques, with neutralizing antibody titers exceeding those typically measured in SARS-CoV-2 seropositive humans by more than one order of magnitude.
References: PMID: 33842900 / doi: 10.1016/j.xcrm.2021.10052
Contact Info: Ben Murrell: [email protected]; Daniel Sheward: [email protected], Gunilla Karlsson Hedestam: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379121000689?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Karolinska Institute, University of Cape Town
Keywords: SARS-CoV-2, spike protein subunit vaccine, mice and primates, immune response
Summary of Study: Adjuvanted protein immunization with soluble SARS-CoV-2 Spike trimers, stabilized in prefusion conformation, results in potent antibody responses in mice and rhesus macaques, with neutralizing antibody titers exceeding those typically measured in SARS-CoV-2 seropositive humans by more than one order of magnitude.
References: PMID: 33842900 / doi: 10.1016/j.xcrm.2021.10052
Contact Info: Ben Murrell: [email protected]; Daniel Sheward: [email protected], Gunilla Karlsson Hedestam: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379121000689?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences
Keywords: SARS-CoV-2, combined intratracheal and intranasal inoculation, virus load, primates
Summary of Study: Nasal infection may be regarded as an important index to assess the severity of COVID-19. Furthermore, treatments focused on nasal infection, like hypertonic saline nasal irrigation and gargling, should be considered as a therapeutic option for COVID-19.
References: PMID: 33587263 / doi: 10.1007/s11427-020-1877-4
Contact Info: Yong-Tang Zheng: [email protected]
URL: https://link.springer.com/article/10.1007%2Fs11427-020-1877-4
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences
Keywords: SARS-CoV-2, combined intratracheal and intranasal inoculation, virus load, primates
Summary of Study: Nasal infection may be regarded as an important index to assess the severity of COVID-19. Furthermore, treatments focused on nasal infection, like hypertonic saline nasal irrigation and gargling, should be considered as a therapeutic option for COVID-19.
References: PMID: 33587263 / doi: 10.1007/s11427-020-1877-4
Contact Info: Yong-Tang Zheng: [email protected]
URL: https://link.springer.com/article/10.1007%2Fs11427-020-1877-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, primates, animal resources, biosafety
Summary of Study: Sustaining and increasing NHP research capacity will require careful preparation and collaborations to improve existing infrastructure and expand established facilities, expertise, and programs.
References: PMID: 33927412 / doi: 10.1038/s41684-021-00760-9
Contact Info: Sheri Ann Hild: [email protected]
URL: https://www.nature.com/articles/s41684-021-00760-9
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, primates, animal resources, biosafety
Summary of Study: Sustaining and increasing NHP research capacity will require careful preparation and collaborations to improve existing infrastructure and expand established facilities, expertise, and programs.
References: PMID: 33927412 / doi: 10.1038/s41684-021-00760-9
Contact Info: Sheri Ann Hild: [email protected]
URL: https://www.nature.com/articles/s41684-021-00760-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: therapeutics
NPRC/Institute: Chinese Academy of Medical Science and Peking Union Medical College; Genuine Biotech, Inc.; Wuhan Research Center for Infectious Diseases and Cancer; The First Affiliated Hospital of Henan University of Chinese Medicine; Henan Provincial Peoples Hospital; Henan Normal University; Zhengzhou University
Keywords: SARS-CoV-2, Azvudine, preclinical studies, Phase III trial, humans, primates
Summary of Study: Treating SARS-CoV-2 infected rhesus macaques with FNC reduced viral load, recuperated the thymus, improved lymphocyte profiles, alleviated inflammation and organ damage, and lessened ground-glass opacities in chest X-ray.
References: PMID: 34873151 / doi: 10.1038/s41392-021-00835-6
Contact Info: Zhenshun Cheng: [email protected]; Jun-Biao Chang: [email protected]; Jian-Dong Jiang: [email protected]
URL: https://www.nature.com/articles/s41392-021-00835-6
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: therapeutics
NPRC/Institute: Chinese Academy of Medical Science and Peking Union Medical College; Genuine Biotech, Inc.; Wuhan Research Center for Infectious Diseases and Cancer; The First Affiliated Hospital of Henan University of Chinese Medicine; Henan Provincial Peoples Hospital; Henan Normal University; Zhengzhou University
Keywords: SARS-CoV-2, Azvudine, preclinical studies, Phase III trial, humans, primates
Summary of Study: Treating SARS-CoV-2 infected rhesus macaques with FNC reduced viral load, recuperated the thymus, improved lymphocyte profiles, alleviated inflammation and organ damage, and lessened ground-glass opacities in chest X-ray.
References: PMID: 34873151 / doi: 10.1038/s41392-021-00835-6
Contact Info: Zhenshun Cheng: [email protected]; Jun-Biao Chang: [email protected]; Jian-Dong Jiang: [email protected]
URL: https://www.nature.com/articles/s41392-021-00835-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Yerkes National Primate Research Center, Emory University School of Medicine, Louisiana State University Health Science Center, Texas Children's Center for Vaccine Development, La Jolla Institute for Immunology, and others.
Keywords: SARS-CoV-2, vaccines and adjuvants, immune response, primates
Summary of Study: The adjuvant 3M-052-alum (previously shown to induce better immune responses against HIV) may be a way to improve the efficacy of SARS-CoV-2 vaccines.
References: PMID: 34266981 / doi: 10.1126/sciimmunol.abh3634
Contact Info: Sudhir Pai Kasturi: [email protected]; Maria Elena Bottazzi: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.abh3634?url_ver=Z39.88-2003&rfr_…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Yerkes National Primate Research Center, Emory University School of Medicine, Louisiana State University Health Science Center, Texas Children's Center for Vaccine Development, La Jolla Institute for Immunology, and others.
Keywords: SARS-CoV-2, vaccines and adjuvants, immune response, primates
Summary of Study: The adjuvant 3M-052-alum (previously shown to induce better immune responses against HIV) may be a way to improve the efficacy of SARS-CoV-2 vaccines.
References: PMID: 34266981 / doi: 10.1126/sciimmunol.abh3634
Contact Info: Sudhir Pai Kasturi: [email protected]; Maria Elena Bottazzi: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.abh3634?url_ver=Z39.88-2003&rfr_…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Wuhan Institute of Virology, Tongji Medical College, University of Chinese Academy of Sciences, Wuhan Institute of Biological Products Co.
Keywords: SARS-CoV-2, inactivated vaccine, mice and primates, immune response
Summary of Study: The authors tested the safety, immunogenicity and efficacy of an inactivated vaccine based on on the whole viral particles in human ACE2 transgenic mouse and in NHPs. This inactivated vaccine successfully induced SARS-CoV-2-specific neutralizing antibodies in both models.
References: PMID: 33835391 / doi: 10.1007/s12250-021-00376-w
Contact Info: Xing-Lou Yang: [email protected]; Shuo Shen: [email protected]; Zhi-Ming Yuan: [email protected]
URL: https://link.springer.com/article/10.1007%2Fs12250-021-00376-w
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Wuhan Institute of Virology, Tongji Medical College, University of Chinese Academy of Sciences, Wuhan Institute of Biological Products Co.
Keywords: SARS-CoV-2, inactivated vaccine, mice and primates, immune response
Summary of Study: The authors tested the safety, immunogenicity and efficacy of an inactivated vaccine based on on the whole viral particles in human ACE2 transgenic mouse and in NHPs. This inactivated vaccine successfully induced SARS-CoV-2-specific neutralizing antibodies in both models.
References: PMID: 33835391 / doi: 10.1007/s12250-021-00376-w
Contact Info: Xing-Lou Yang: [email protected]; Shuo Shen: [email protected]; Zhi-Ming Yuan: [email protected]
URL: https://link.springer.com/article/10.1007%2Fs12250-021-00376-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Xiamen University, The University of HongKong, Shantou University, Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, review of the primate models, clinical symptoms, pathogenesis, applications
Summary of Study: Review summarizes the benefits and caveats of NHP models currently available for SARS-CoV-2 and discusses key topics including model optimization, extended application, and clinical translation.
References: PMID: 34490832 / doi: 10.1080/22221751.2021.1976598
Contact Info: Tong Cheng: [email protected]; Ningshao Xia: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1976598
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Xiamen University, The University of HongKong, Shantou University, Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, review of the primate models, clinical symptoms, pathogenesis, applications
Summary of Study: Review summarizes the benefits and caveats of NHP models currently available for SARS-CoV-2 and discusses key topics including model optimization, extended application, and clinical translation.
References: PMID: 34490832 / doi: 10.1080/22221751.2021.1976598
Contact Info: Tong Cheng: [email protected]; Ningshao Xia: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1976598
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Kazan State Medical Academy; Kazan State Medical University; Kazan Federal University
Keywords: SARS-CoV-2, infection, pathogenicity, eye surface, literature meta analysis, primates
Summary of Study: There is a possibility of COVID-19 transmission through the eye surface. Eye protection measures should be undertaken when working with potentially infected patients.
References: PMID: 34410064 / doi: 10.17116/oftalma2021137041104
Contact Info: not provided
URL: https://pubmed.ncbi.nlm.nih.gov/34410064/
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Kazan State Medical Academy; Kazan State Medical University; Kazan Federal University
Keywords: SARS-CoV-2, infection, pathogenicity, eye surface, literature meta analysis, primates
Summary of Study: There is a possibility of COVID-19 transmission through the eye surface. Eye protection measures should be undertaken when working with potentially infected patients.
References: PMID: 34410064 / doi: 10.17116/oftalma2021137041104
Contact Info: not provided
URL: https://pubmed.ncbi.nlm.nih.gov/34410064/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Texas Medical Branch, Pfizer
Keywords: SARS-CoV-2, vaccine-elicited immunity, virus variant, primates
Summary of Study: The D614G mutation modestly reduced SARS-CoV-2 neutralization by BNT162b2 vaccine-elicited mouse, rhesus, and human sera, concurring with the 95% vaccine efficacy observed in clinical trial.
References: PMID: 33767200 / doi: 10.1038/s41541-021-00313-8
Contact Info: Philip Dormitzer: philip,[email protected]
URL: https://www.nature.com/articles/s41541-021-00313-8
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Texas Medical Branch, Pfizer
Keywords: SARS-CoV-2, vaccine-elicited immunity, virus variant, primates
Summary of Study: The D614G mutation modestly reduced SARS-CoV-2 neutralization by BNT162b2 vaccine-elicited mouse, rhesus, and human sera, concurring with the 95% vaccine efficacy observed in clinical trial.
References: PMID: 33767200 / doi: 10.1038/s41541-021-00313-8
Contact Info: Philip Dormitzer: philip,[email protected]
URL: https://www.nature.com/articles/s41541-021-00313-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, marmosets, rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Fudan University, Shanghai, China
Keywords: SARS-CoV-2, review, transmission, pathogenicity, therapeutics, ferrets, minks, tree shrews, primates
Summary of Study: Animal models of SARS-CoV-2 are reviewed and compared.
References: PMID: 34531831 / doi: 10.3389/fmicb.2021.626553
Contact Info: Youhua Xie: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2021.626553/full
NHP Species: african green monkeys, marmosets, rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Fudan University, Shanghai, China
Keywords: SARS-CoV-2, review, transmission, pathogenicity, therapeutics, ferrets, minks, tree shrews, primates
Summary of Study: Animal models of SARS-CoV-2 are reviewed and compared.
References: PMID: 34531831 / doi: 10.3389/fmicb.2021.626553
Contact Info: Youhua Xie: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2021.626553/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Universite Paris-Saclay, Inserm; Pereman School of Medicine; Novartis Gene Therapies; Boston University School of Medicine; Institute Pasteur; Mass General Brigham Innovation; Albamunity
Keywords: SARS-CoV-2, AAV-based vaccine, immunogenicity, thermostability, mice, primates
Summary of Study: AAVrh32.33 technology demonstrated its utility as a preventative vaccine for COVID19, and its unique attributes may be applicable to other pathogens or immunization targets.
References: PMID: 34428428 / doi: 10.1016/j.chom.2021.08.002
Contact Info: Luk Vandenberghe: [email protected]; Roger Le Grand: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1931312821003784?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Universite Paris-Saclay, Inserm; Pereman School of Medicine; Novartis Gene Therapies; Boston University School of Medicine; Institute Pasteur; Mass General Brigham Innovation; Albamunity
Keywords: SARS-CoV-2, AAV-based vaccine, immunogenicity, thermostability, mice, primates
Summary of Study: AAVrh32.33 technology demonstrated its utility as a preventative vaccine for COVID19, and its unique attributes may be applicable to other pathogens or immunization targets.
References: PMID: 34428428 / doi: 10.1016/j.chom.2021.08.002
Contact Info: Luk Vandenberghe: [email protected]; Roger Le Grand: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1931312821003784?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Stanford Univ. SOM, Univ. of Washington, Tulane National Primate Research Center, Yerkes National Primate Research Center, and others
Keywords: SARS-CoV-2, subunit vaccine, immune response, primates
Summary of Study: Data highlighted the efficacy of the adjuvanted RBD-NP vaccine in promoting protective immunity against SARS-Cov-2 and have led to phase I/II clinical trials of this vaccine.
References: PMID: 33873199 / doi: 10.1038/s41586-021-03530-2
Contact Info: Bali Pulendran: [email protected];
URL: https://www.nature.com/articles/s41586-021-03530-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Stanford Univ. SOM, Univ. of Washington, Tulane National Primate Research Center, Yerkes National Primate Research Center, and others
Keywords: SARS-CoV-2, subunit vaccine, immune response, primates
Summary of Study: Data highlighted the efficacy of the adjuvanted RBD-NP vaccine in promoting protective immunity against SARS-Cov-2 and have led to phase I/II clinical trials of this vaccine.
References: PMID: 33873199 / doi: 10.1038/s41586-021-03530-2
Contact Info: Bali Pulendran: [email protected];
URL: https://www.nature.com/articles/s41586-021-03530-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences, Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)
Keywords: SARS-CoV-2, immunopathology, young and old animals, primates
Summary of Study: Results showed that the age-related immune microenvironment in the lungs, spleens, PBMCs , and CD8+ cells significantly affected the immunopathology of SARS-CoV-2 infection, whereas the increase in inflammatory factor-secreting cells in the lungs and systemic accumulation of CXCR3+ cells are associated with necrosis and inflammatory activation of ACE2+ lung cells.
References: PMID: 34471088 / doi: 10.1038/s41392-021-00734-w
Contact Info: Yong-Tang Zheng: [email protected]
URL: https://www.nature.com/articles/s41392-021-00734-w
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences, Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)
Keywords: SARS-CoV-2, immunopathology, young and old animals, primates
Summary of Study: Results showed that the age-related immune microenvironment in the lungs, spleens, PBMCs , and CD8+ cells significantly affected the immunopathology of SARS-CoV-2 infection, whereas the increase in inflammatory factor-secreting cells in the lungs and systemic accumulation of CXCR3+ cells are associated with necrosis and inflammatory activation of ACE2+ lung cells.
References: PMID: 34471088 / doi: 10.1038/s41392-021-00734-w
Contact Info: Yong-Tang Zheng: [email protected]
URL: https://www.nature.com/articles/s41392-021-00734-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Institut Pasteur; Sorbonne Universite; Ecole normale superieure Paris-Saclay; Universite de Paris
Keywords: SARS-CoV-2, therapeutics, vaccine, pathogenesis, drug discovery, animal model, primates
Summary of Study: This review discusses the use of NHPs as models for COVID-19 research, with focus on the pathogenesis of SARS-CoV-2 infection, drug discovery and pre-clinical evaluation of vaccine candidates.
References: PMID: 34452011 / doi: 10.3390/vaccines9080886
Contact Info: Caroline Passaes: [email protected]
URL: https://www.mdpi.com/2076-393X/9/8/886
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Institut Pasteur; Sorbonne Universite; Ecole normale superieure Paris-Saclay; Universite de Paris
Keywords: SARS-CoV-2, therapeutics, vaccine, pathogenesis, drug discovery, animal model, primates
Summary of Study: This review discusses the use of NHPs as models for COVID-19 research, with focus on the pathogenesis of SARS-CoV-2 infection, drug discovery and pre-clinical evaluation of vaccine candidates.
References: PMID: 34452011 / doi: 10.3390/vaccines9080886
Contact Info: Caroline Passaes: [email protected]
URL: https://www.mdpi.com/2076-393X/9/8/886
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Janssen Vaccines, Leiden University Medical Center, Harvard Medical School
Keywords: SARS-CoV-2, adenovirus vectored COVID-19 vaccine, immune response, pathology, primates
Summary of Study: The immunogenicity, protective efficacy, and SARS-CoV-2 spike variant neutralizing data presented in this manuscript further support the decision to evaluate a single 5 x 10^10-vp dose of Ad26.COV2.S in Phase 3 trials.
References: PMID: 33909009 / doi: 10.1084/jem.20202756
Contact Info: Roland Zahn: [email protected]
URL: https://rupress.org/jem/article/218/7/e20202756/212032/Immunogenicity-and-effic…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Janssen Vaccines, Leiden University Medical Center, Harvard Medical School
Keywords: SARS-CoV-2, adenovirus vectored COVID-19 vaccine, immune response, pathology, primates
Summary of Study: The immunogenicity, protective efficacy, and SARS-CoV-2 spike variant neutralizing data presented in this manuscript further support the decision to evaluate a single 5 x 10^10-vp dose of Ad26.COV2.S in Phase 3 trials.
References: PMID: 33909009 / doi: 10.1084/jem.20202756
Contact Info: Roland Zahn: [email protected]
URL: https://rupress.org/jem/article/218/7/e20202756/212032/Immunogenicity-and-effic…
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: United States Army Medical Research Institute of Infectious Diseases
Keywords: SARS-CoV-2, comparative evaluation of disease progression in three primate species
Summary of Study: In addition to African green monkeys, macaques can be successfully infected by airborne SARS-CoV-2, providing viable macaque natural transmission models for medical countermeasure evaluation.
References: PMID: 33529233 / doi: 10.1371/journal.pone.0246366
Contact Info: Sara Johnston: [email protected]; Aysegul Nalca: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0246366
NHP Species: african green monkeys, rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: United States Army Medical Research Institute of Infectious Diseases
Keywords: SARS-CoV-2, comparative evaluation of disease progression in three primate species
Summary of Study: In addition to African green monkeys, macaques can be successfully infected by airborne SARS-CoV-2, providing viable macaque natural transmission models for medical countermeasure evaluation.
References: PMID: 33529233 / doi: 10.1371/journal.pone.0246366
Contact Info: Sara Johnston: [email protected]; Aysegul Nalca: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0246366
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre (BPRC); Utrecht University
Keywords: SARS-CoV-2, chest CT, ultrasound, pulmonary lesions, primates
Summary of Study: As has been observed in humans, the sensitivity of lung ultrasound (LUS) is high though the diagnostic efficacy or mild-to-moderate disease is relatively low. The low efficacy outweighs the advantages of LUS over CT (i.e. no need to transport the animals and the absence of ionizing radiation). For this reason, CT is still the imaging modality of choice for diagnosis, monitoring, and longitudinal assessment of a SARS-CoV-2 infection in NHPs.
References: PMID: 34778433 / doi: 10.3389/fvets.2021.748635
Contact Info: Marieke Stammes: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fvets.2021.748635/full
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre (BPRC); Utrecht University
Keywords: SARS-CoV-2, chest CT, ultrasound, pulmonary lesions, primates
Summary of Study: As has been observed in humans, the sensitivity of lung ultrasound (LUS) is high though the diagnostic efficacy or mild-to-moderate disease is relatively low. The low efficacy outweighs the advantages of LUS over CT (i.e. no need to transport the animals and the absence of ionizing radiation). For this reason, CT is still the imaging modality of choice for diagnosis, monitoring, and longitudinal assessment of a SARS-CoV-2 infection in NHPs.
References: PMID: 34778433 / doi: 10.3389/fvets.2021.748635
Contact Info: Marieke Stammes: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fvets.2021.748635/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Department of Virology, Aggeu Magalhaes Institute, Brazil
Keywords: SARS-CoV-2, in vitro and in vivo models, several animal species, including primates, review
Summary of Study: This review article summarizes the main models of SARS-CoV-2 infection developed so far and discusses their advantages, drawbacks and main uses.
References: PMID: 33673614 / doi: 10.3390/v13030379
Contact Info: Lindomar Pena: [email protected]
URL: https://www.mdpi.com/1999-4915/13/3/379/htm
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Department of Virology, Aggeu Magalhaes Institute, Brazil
Keywords: SARS-CoV-2, in vitro and in vivo models, several animal species, including primates, review
Summary of Study: This review article summarizes the main models of SARS-CoV-2 infection developed so far and discusses their advantages, drawbacks and main uses.
References: PMID: 33673614 / doi: 10.3390/v13030379
Contact Info: Lindomar Pena: [email protected]
URL: https://www.mdpi.com/1999-4915/13/3/379/htm
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Texas Christian University
Keywords: SARS-CoV-2, young and aged animals, viral dynamics, antiviral treatment, primates
Summary of Study: This study finds the viral dynamics of SARS-CoV-2 between young and aged animals and has shown that these differences should be considered when considering antiviral treatment.
References: PMID: 34804559 / doi: 10.1098/rsos.202345
Contact Info: Hana Dobrovolny: [email protected]
URL: https://royalsocietypublishing.org/doi/full/10.1098/rsos.202345?rfr_dat=cr_pub%…
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Texas Christian University
Keywords: SARS-CoV-2, young and aged animals, viral dynamics, antiviral treatment, primates
Summary of Study: This study finds the viral dynamics of SARS-CoV-2 between young and aged animals and has shown that these differences should be considered when considering antiviral treatment.
References: PMID: 34804559 / doi: 10.1098/rsos.202345
Contact Info: Hana Dobrovolny: [email protected]
URL: https://royalsocietypublishing.org/doi/full/10.1098/rsos.202345?rfr_dat=cr_pub%…
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, animal models, viruses, resources, primates
Summary of Study: The SARS-CoV-2/COVID-19 pandemic has significantly increased the demand for specific-pathogen-free (SPF) nonhuman primates (NHPs) for development of vaccines and therapeutics, thus straining the supply of these animals for biomedical research studies. Non-SPF animals, which are available in greater numbers and include well-characterized primate species, should be considered in lieu of limited SPF animals for appropriate research studies.
References: PMID: 34163043 / doi: 10.1038/s41684-021-008102
Contact Info: Miguel Contreras: [email protected]
URL: https://www.nature.com/articles/s41684-021-00810-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, animal models, viruses, resources, primates
Summary of Study: The SARS-CoV-2/COVID-19 pandemic has significantly increased the demand for specific-pathogen-free (SPF) nonhuman primates (NHPs) for development of vaccines and therapeutics, thus straining the supply of these animals for biomedical research studies. Non-SPF animals, which are available in greater numbers and include well-characterized primate species, should be considered in lieu of limited SPF animals for appropriate research studies.
References: PMID: 34163043 / doi: 10.1038/s41684-021-008102
Contact Info: Miguel Contreras: [email protected]
URL: https://www.nature.com/articles/s41684-021-00810-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIAID
Keywords: SARS-CoV-2, virus genomic variants, virus replication, immune response, pathology, primates
Summary of Study: A study of pathogenesis of B.1.1.7 and B.1.351 compared to a SARS-CoV-2 isolate containing the D614G spike substitution showed that B.1.351 was slightly less pathogenic than the other two variants, but there were no differences in virus shedding between the variants that could explain increased transmissibility.
References: PMID: 34678071 / doi: 10.1126/sciadv.abj3627
Contact Info: Emmie de Wit: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.abj3627?url_ver=Z39.88-2003&rfr_id=o…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIAID
Keywords: SARS-CoV-2, virus genomic variants, virus replication, immune response, pathology, primates
Summary of Study: A study of pathogenesis of B.1.1.7 and B.1.351 compared to a SARS-CoV-2 isolate containing the D614G spike substitution showed that B.1.351 was slightly less pathogenic than the other two variants, but there were no differences in virus shedding between the variants that could explain increased transmissibility.
References: PMID: 34678071 / doi: 10.1126/sciadv.abj3627
Contact Info: Emmie de Wit: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.abj3627?url_ver=Z39.88-2003&rfr_id=o…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, pigtail macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Fred Hutchinson Cancer Research Center; University of Washington; Washington National Primate Research Center; NIAID
Keywords: SARS-CoV-2, phage-based deep mutational scanning, epitope targets, spike protein, humans, primates
Summary of Study: Findings suggest that the antibody response to SARS-CoV-2 in macaques shares many features with humans, but with substantial differences in the recognition of certain epitopes and considerable individual variability in antibody escape profiles, suggesting a diverse repertoire of antibodies that can respond to major epitopes in both humans and macaques.
References: PMID: 34909774 / doi: 10.1101/2021.12.01.470697
Contact Info: Julie Overbaugh: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.12.01.470697v1
NHP Species: rhesus macaques, pigtail macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Fred Hutchinson Cancer Research Center; University of Washington; Washington National Primate Research Center; NIAID
Keywords: SARS-CoV-2, phage-based deep mutational scanning, epitope targets, spike protein, humans, primates
Summary of Study: Findings suggest that the antibody response to SARS-CoV-2 in macaques shares many features with humans, but with substantial differences in the recognition of certain epitopes and considerable individual variability in antibody escape profiles, suggesting a diverse repertoire of antibodies that can respond to major epitopes in both humans and macaques.
References: PMID: 34909774 / doi: 10.1101/2021.12.01.470697
Contact Info: Julie Overbaugh: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.12.01.470697v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets, howler monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Instituto Federal do Norte de Minas Gerais, Brazil; Universidade Federal dos Vales do Jequitinhonha e Mucuri, Brazil; Centro Estadual de Vigilancia em Saude; Universidade de Brasilia; Universidade Federal de Minas Gerais; State University of Santa Cruz; Universidade Federal de Tocantins
Keywords: SARS-CoV-2, wild animals, RT-qPCR, primates
Summary of Study: 51 NHPs were examined for signs of SARS-CoV-2; 89 samples of various tissues were analyzed, with no SARS-CoV-2 positive samples detected, regardless of NHP species, tissue, habitat, municipalities or state/biome tested.
References: PMID: 34843021 / doi: 10.1007/s10393-021-01569-1
Contact Info: Danilo Bretas de Oliveira: [email protected]
URL: https://link.springer.com/article/10.1007%2Fs10393-021-01569-1
NHP Species: marmosets, howler monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Instituto Federal do Norte de Minas Gerais, Brazil; Universidade Federal dos Vales do Jequitinhonha e Mucuri, Brazil; Centro Estadual de Vigilancia em Saude; Universidade de Brasilia; Universidade Federal de Minas Gerais; State University of Santa Cruz; Universidade Federal de Tocantins
Keywords: SARS-CoV-2, wild animals, RT-qPCR, primates
Summary of Study: 51 NHPs were examined for signs of SARS-CoV-2; 89 samples of various tissues were analyzed, with no SARS-CoV-2 positive samples detected, regardless of NHP species, tissue, habitat, municipalities or state/biome tested.
References: PMID: 34843021 / doi: 10.1007/s10393-021-01569-1
Contact Info: Danilo Bretas de Oliveira: [email protected]
URL: https://link.springer.com/article/10.1007%2Fs10393-021-01569-1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: California National Primate Research Center, UC Davis School of Medicine, The Rockefeller University, UC Davis School of Veterinary Medicine, DMID/NIAID/NIH, Howard Hughes Medical Institute
Keywords: SARS-CoV-2, therapeutic interventions, neutralizing monoclonal antibodies, pathology, primates
Summary of Study: Study provides proof-of-concept in support of further clinical development of monoclonal antibodies C135-LS and C144-LS against COVID-19 during early infection.
References: PMID: 34228761 / doi: 10.1371/journal.ppat.1009688
Contact Info: Koen Van Rompay: [email protected]; Michel Nussenzweig: [email protected]; J. Rachel Reader: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009688
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: California National Primate Research Center, UC Davis School of Medicine, The Rockefeller University, UC Davis School of Veterinary Medicine, DMID/NIAID/NIH, Howard Hughes Medical Institute
Keywords: SARS-CoV-2, therapeutic interventions, neutralizing monoclonal antibodies, pathology, primates
Summary of Study: Study provides proof-of-concept in support of further clinical development of monoclonal antibodies C135-LS and C144-LS against COVID-19 during early infection.
References: PMID: 34228761 / doi: 10.1371/journal.ppat.1009688
Contact Info: Koen Van Rompay: [email protected]; Michel Nussenzweig: [email protected]; J. Rachel Reader: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009688
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Agricultural Sciences; National Research Center for Exotic Animal Diseases, China Animal Health and Epidemiology Center
Keywords: SARS-CoV-2, meta analysis, review of the animal models, vaccination, mice, hamsters, ferrets, primates
Summary of Study: This review summarizes the landscape of animal models for COVID-19 vaccine evaluation and advanced vaccines with an efficacy range from about 50% to more than 95%.
References: PMID: 34696190 / doi: 10.3390/vaccines9101082
Contact Info: Yuwei Gao: [email protected]; Feihu Yan: [email protected]; Songtao Yang: [email protected]
URL: https://www.mdpi.com/2076-393X/9/10/1082
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Agricultural Sciences; National Research Center for Exotic Animal Diseases, China Animal Health and Epidemiology Center
Keywords: SARS-CoV-2, meta analysis, review of the animal models, vaccination, mice, hamsters, ferrets, primates
Summary of Study: This review summarizes the landscape of animal models for COVID-19 vaccine evaluation and advanced vaccines with an efficacy range from about 50% to more than 95%.
References: PMID: 34696190 / doi: 10.3390/vaccines9101082
Contact Info: Yuwei Gao: [email protected]; Feihu Yan: [email protected]; Songtao Yang: [email protected]
URL: https://www.mdpi.com/2076-393X/9/10/1082
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Institute of Advanced Study in Science and Technology (India), Biodiversity Research Center, Academic Sinica (Taipei) and others
Keywords: SARS-CoV-2, ACE2 variants, binding affinity of ACE2 to S-protein, multiple species, humans and primates
Summary of Study: Binding affinity of ACE2 to S-protein was studied in various NHP species. Based on findings, the authors propose that the common ancestor of primates was strongly resistant to and that of New World monkeys was completely resistant to SARS-CoV-2; whereas apes and Old World monkeys, like most humans, are susceptible. This study increases our understanding of the differences in susceptibility to SARS-CV-2 infection among primates.
References: PMID: 33674876 / doi: 10.1093/molbev/msab060
Contact Info: Yan Yuan Tseng: [email protected]; Lily Hui-Ching Wang: [email protected]
URL: https://academic.oup.com/mbe/advance-article/doi/10.1093/molbev/msab060/6154855
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Institute of Advanced Study in Science and Technology (India), Biodiversity Research Center, Academic Sinica (Taipei) and others
Keywords: SARS-CoV-2, ACE2 variants, binding affinity of ACE2 to S-protein, multiple species, humans and primates
Summary of Study: Binding affinity of ACE2 to S-protein was studied in various NHP species. Based on findings, the authors propose that the common ancestor of primates was strongly resistant to and that of New World monkeys was completely resistant to SARS-CoV-2; whereas apes and Old World monkeys, like most humans, are susceptible. This study increases our understanding of the differences in susceptibility to SARS-CV-2 infection among primates.
References: PMID: 33674876 / doi: 10.1093/molbev/msab060
Contact Info: Yan Yuan Tseng: [email protected]; Lily Hui-Ching Wang: [email protected]
URL: https://academic.oup.com/mbe/advance-article/doi/10.1093/molbev/msab060/6154855
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Beijing Institute of Microbiology & Immunology; Institute of Military Veterinary, Academic of Military Medical Sciences
Keywords: SARS-CoV-2, recombinant vaccine, efficacy of RBD-Fc Vacc, mice and primates
Summary of Study: A new recombinant vaccine made by fusing the SARS-CoV-2 RBD with the Fc fragment of human IgG1induced a potent immune response, protecting cynomolgus macaques against SARS-CoV-2 infection.
References: PMID: 33731916 / doi: 10.1038/s41423-021-00658-z
Contact Info: Yansong Sun: [email protected]; Yuwei Gao: [email protected]
URL: https://www.nature.com/articles/s41423-021-00658-z
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Beijing Institute of Microbiology & Immunology; Institute of Military Veterinary, Academic of Military Medical Sciences
Keywords: SARS-CoV-2, recombinant vaccine, efficacy of RBD-Fc Vacc, mice and primates
Summary of Study: A new recombinant vaccine made by fusing the SARS-CoV-2 RBD with the Fc fragment of human IgG1induced a potent immune response, protecting cynomolgus macaques against SARS-CoV-2 infection.
References: PMID: 33731916 / doi: 10.1038/s41423-021-00658-z
Contact Info: Yansong Sun: [email protected]; Yuwei Gao: [email protected]
URL: https://www.nature.com/articles/s41423-021-00658-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Yerkes National Primate Research Center, Duke University School of Medicine, Harvard
Keywords: SARS-CoV-2, modified vaccinia Ankara vector-based vaccine, immune response, pathology, primates
Summary of Study: MVA/S vaccination can provide protection from intranasal and intratracheal SARS-CoV-2 challenge and support further development of this vaccine to test immunogenicity and efficacy in humans.
References: PMID: 33631118 / doi: 10.1016/j.immuni.2021.02.001
Contact Info: Rama Rao Amara: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S107476132100042X?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Yerkes National Primate Research Center, Duke University School of Medicine, Harvard
Keywords: SARS-CoV-2, modified vaccinia Ankara vector-based vaccine, immune response, pathology, primates
Summary of Study: MVA/S vaccination can provide protection from intranasal and intratracheal SARS-CoV-2 challenge and support further development of this vaccine to test immunogenicity and efficacy in humans.
References: PMID: 33631118 / doi: 10.1016/j.immuni.2021.02.001
Contact Info: Rama Rao Amara: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S107476132100042X?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Institute of Medical Biology, Chinese Academy of Medical Sciences & U. Mass.
Keywords: SARS-CoV-2, DNA and protein vaccine combination, primates
Summary of Study: The novel combination of a DNA vaccine encoding the full-length Spike (S) protein of SARS-CoV-2 and a recombinant S1 protein vaccine elicited full protection against the challenge of SARS-CoV-2 in an NHP model.
References: PMID: 33555988 / doi: 10.1080/22221751.2021.1887767
Contact Info: Wei Cun: [email protected] / Shan Lu: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1887767
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Institute of Medical Biology, Chinese Academy of Medical Sciences & U. Mass.
Keywords: SARS-CoV-2, DNA and protein vaccine combination, primates
Summary of Study: The novel combination of a DNA vaccine encoding the full-length Spike (S) protein of SARS-CoV-2 and a recombinant S1 protein vaccine elicited full protection against the challenge of SARS-CoV-2 in an NHP model.
References: PMID: 33555988 / doi: 10.1080/22221751.2021.1887767
Contact Info: Wei Cun: [email protected] / Shan Lu: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1887767
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Indian Council of Medical Research-National Institute of Virology
Keywords: SARS-CoV-2, inactivated SARS-CoV-2 vaccine candidate, immunogenicity, efficacy, primates
Summary of Study: A two-dose regimen of vaccine candidate BBV152 with adjuvant B induces a significant immune response and provides effective protection in rhesus macaques challenged with SARS-CoV-2.
References: PMID: 33654090 / doi: 10.1038/s41467-021-21639-w
Contact Info: Balram Bhargava: [email protected]
URL: https://www.nature.com/articles/s41467-021-21639-w
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Indian Council of Medical Research-National Institute of Virology
Keywords: SARS-CoV-2, inactivated SARS-CoV-2 vaccine candidate, immunogenicity, efficacy, primates
Summary of Study: A two-dose regimen of vaccine candidate BBV152 with adjuvant B induces a significant immune response and provides effective protection in rhesus macaques challenged with SARS-CoV-2.
References: PMID: 33654090 / doi: 10.1038/s41467-021-21639-w
Contact Info: Balram Bhargava: [email protected]
URL: https://www.nature.com/articles/s41467-021-21639-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Beth Israel Deaconess Medical Center, MIT, Harvard
Keywords: SARS-CoV-2, DNA- and Ad26-based vaccines, serum profiles, primates
Summary of Study: Data highlight the similarities between infection and vaccine induced humoral immunity for SARS-Cov-2 and cross-reactivity of these responses to other CoVs.
References: PMID: 33692201 / doi: 10.1128/JVI.00117-21
Contact Info: Dan Barouch: [email protected]
URL: https://journals.asm.org/doi/10.1128/JVI.00117-21?url_ver=Z39.88-2003&rfr_id=or…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Beth Israel Deaconess Medical Center, MIT, Harvard
Keywords: SARS-CoV-2, DNA- and Ad26-based vaccines, serum profiles, primates
Summary of Study: Data highlight the similarities between infection and vaccine induced humoral immunity for SARS-Cov-2 and cross-reactivity of these responses to other CoVs.
References: PMID: 33692201 / doi: 10.1128/JVI.00117-21
Contact Info: Dan Barouch: [email protected]
URL: https://journals.asm.org/doi/10.1128/JVI.00117-21?url_ver=Z39.88-2003&rfr_id=or…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Ragon Institute of MGH, MIT, and Harvard; Novavax; University of Duisburg-Essen; MIT; Texas Biomedical Research Institute; University of Maryland School of Medicine; Duke University Medical Center; La Jolla Institute for Immunology; and others
Keywords: SARS-CoV-2, humoral immune response, vaccine-induced antibody fingerprint, protection, primates
Summary of Study: Data presented suggest that a single dose may prevent disease via combined Fc/Fab functions but that two doses may be essential to block further transmission of SARS-CoV-2 and emerging variants.
References: PMID: 34485950 / doi: 10.1016/j.xcrm.2021.100405
Contact Info: Gale Smith: [email protected]; Galit Alter: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009701
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Ragon Institute of MGH, MIT, and Harvard; Novavax; University of Duisburg-Essen; MIT; Texas Biomedical Research Institute; University of Maryland School of Medicine; Duke University Medical Center; La Jolla Institute for Immunology; and others
Keywords: SARS-CoV-2, humoral immune response, vaccine-induced antibody fingerprint, protection, primates
Summary of Study: Data presented suggest that a single dose may prevent disease via combined Fc/Fab functions but that two doses may be essential to block further transmission of SARS-CoV-2 and emerging variants.
References: PMID: 34485950 / doi: 10.1016/j.xcrm.2021.100405
Contact Info: Gale Smith: [email protected]; Galit Alter: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009701
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Janssen Vaccines & Prevention B.V.; Harvard Medical School; Lucidity Biomedical Consulting; Ragon Institute of MGH, MIT and Harvard; Massachusetts Consortium on Pathogen Readiness
Keywords: SARS-CoV-2, adenovirus vector, immunogenicity, protective efficacy, immune response, primates
Summary of Study: Ad26.COV2.S vaccine confers durable protection against replication of SARS-CoV-2 in the lungs that is predicted by the levels of Spike-binding and neutralizing antibodies, indicating that Ad26.COV2.S could confer durable protection in humans and immunological correlates of protection may enable the prediction of durability of protection.
References: PMID: 34620860 / doi: 10.1038/s41467-021-26117-x
Contact Info: Roland Zahn: [email protected]
URL: https://www.nature.com/articles/s41467-021-26117-x
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Janssen Vaccines & Prevention B.V.; Harvard Medical School; Lucidity Biomedical Consulting; Ragon Institute of MGH, MIT and Harvard; Massachusetts Consortium on Pathogen Readiness
Keywords: SARS-CoV-2, adenovirus vector, immunogenicity, protective efficacy, immune response, primates
Summary of Study: Ad26.COV2.S vaccine confers durable protection against replication of SARS-CoV-2 in the lungs that is predicted by the levels of Spike-binding and neutralizing antibodies, indicating that Ad26.COV2.S could confer durable protection in humans and immunological correlates of protection may enable the prediction of durability of protection.
References: PMID: 34620860 / doi: 10.1038/s41467-021-26117-x
Contact Info: Roland Zahn: [email protected]
URL: https://www.nature.com/articles/s41467-021-26117-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: SW National Primate Research Center, Washington University School of Medicine, Texas Biomedical Research Institute, Tulane University
Keywords: SARS-CoV-2, single-cell RNA sequencing. Immune response, primates
Summary of Study: The recruitment of a myeloid-cell-mediated Type I IFN response is associated with the rapid clearance of SARS-CoV-2 infection in macaques.
References: PMID: 34282414 / doi: 10.21203/rs.3.rs-664507/v1
Contact Info: Deepak Kaushal: [email protected]
URL: https://www.researchsquare.com/article/rs-664507/v1
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: SW National Primate Research Center, Washington University School of Medicine, Texas Biomedical Research Institute, Tulane University
Keywords: SARS-CoV-2, single-cell RNA sequencing. Immune response, primates
Summary of Study: The recruitment of a myeloid-cell-mediated Type I IFN response is associated with the rapid clearance of SARS-CoV-2 infection in macaques.
References: PMID: 34282414 / doi: 10.21203/rs.3.rs-664507/v1
Contact Info: Deepak Kaushal: [email protected]
URL: https://www.researchsquare.com/article/rs-664507/v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Public Health England; University of Oxford; Oxford University Hospitals NHS Foundation Trust; Quadram Institute Bioscience
Keywords: SARS-CoV-2, inactivated vaccine, vaccine-enhanced disease, pathology, ferrets, primates
Summary of Study: Studies assessed the potential for VED (vaccine-enhanced disease) in animals vaccinated with formaldehyde-inactivated SARS-CoV-2 formulated with Alhydrogel, compared to a negative control vaccine. No evidence of enhanced disease was shown in ferrets of rhesus macaques except for mild transient enhanced disease seen 7 days after infection in ferrets. This was resolved by day 15.
References: PMID: 34516768 / doi: 10.1126/sciadv.abg7996
Contact Info: Miles Carol: [email protected]; Andrew Gorringe: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.abg7996?url_ver=Z39.88-2003&rfr_id=o…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Public Health England; University of Oxford; Oxford University Hospitals NHS Foundation Trust; Quadram Institute Bioscience
Keywords: SARS-CoV-2, inactivated vaccine, vaccine-enhanced disease, pathology, ferrets, primates
Summary of Study: Studies assessed the potential for VED (vaccine-enhanced disease) in animals vaccinated with formaldehyde-inactivated SARS-CoV-2 formulated with Alhydrogel, compared to a negative control vaccine. No evidence of enhanced disease was shown in ferrets of rhesus macaques except for mild transient enhanced disease seen 7 days after infection in ferrets. This was resolved by day 15.
References: PMID: 34516768 / doi: 10.1126/sciadv.abg7996
Contact Info: Miles Carol: [email protected]; Andrew Gorringe: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.abg7996?url_ver=Z39.88-2003&rfr_id=o…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre (BPRC, Netherlands), Utrecht University
Keywords: SARS-CoV-2, computed tomography, bronchoalveolar lavage, test interference, primates
Summary of Study: Thorax CTs were evaluated for alterations in lung density in health and experimentally SARS-CoV-infected female rhesus macaques before and after bronchoalveolar lavage (BAL). An increase in the lung density was observed on the post-BAL CT but resolved within 24 hours in the healthy animals; a significant difference in both the lung density and CT score was still found 24 hours post BAL in the infected animals.
References: PMID: 34242213 / doi: 10.1371/journal.pone.0252941
Contact Info: Marieke Stammes: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0252941
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre (BPRC, Netherlands), Utrecht University
Keywords: SARS-CoV-2, computed tomography, bronchoalveolar lavage, test interference, primates
Summary of Study: Thorax CTs were evaluated for alterations in lung density in health and experimentally SARS-CoV-infected female rhesus macaques before and after bronchoalveolar lavage (BAL). An increase in the lung density was observed on the post-BAL CT but resolved within 24 hours in the healthy animals; a significant difference in both the lung density and CT score was still found 24 hours post BAL in the infected animals.
References: PMID: 34242213 / doi: 10.1371/journal.pone.0252941
Contact Info: Marieke Stammes: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0252941
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, ACE2 expression, transcription factor AhR, pathology, primates
Summary of Study: Data in this study show that the transcription factor AhR is able to bind the promoter of the ACE2 gene, thus promoting ACE2 expression and augmenting the subsequent pathology in SARS-CoV-2-infected lungs.
References: PMID: 33795851 / doi: 10.1038/s41423-021-00672-1
Contact Info: Chuan Qin: [email protected]; Bo Huang: [email protected]
URL: https://www.nature.com/articles/s41423-021-00672-1
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, ACE2 expression, transcription factor AhR, pathology, primates
Summary of Study: Data in this study show that the transcription factor AhR is able to bind the promoter of the ACE2 gene, thus promoting ACE2 expression and augmenting the subsequent pathology in SARS-CoV-2-infected lungs.
References: PMID: 33795851 / doi: 10.1038/s41423-021-00672-1
Contact Info: Chuan Qin: [email protected]; Bo Huang: [email protected]
URL: https://www.nature.com/articles/s41423-021-00672-1
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Yale School of Medicine, Johns Hopkins School of Medicine
Keywords: SARS-CoV-2, ACE2, several animal species, immune response, pathology, primates
Summary of Study: This review summarized key clinical, radiologic, and pathologic features of human COVID-19, followed by a comparison with spontaneous and genetically altered animal models of SARS-CoV-2 infection.
References: PMID: 33836527 / doi: 10.1093/ilar/ilab0071
Contact Info: Caroline Zeiss: [email protected]
URL: https://academic.oup.com/ilarjournal/advance-article/doi/10.1093/ilar/ilab007/6…
NHP Species: african green monkeys, rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Yale School of Medicine, Johns Hopkins School of Medicine
Keywords: SARS-CoV-2, ACE2, several animal species, immune response, pathology, primates
Summary of Study: This review summarized key clinical, radiologic, and pathologic features of human COVID-19, followed by a comparison with spontaneous and genetically altered animal models of SARS-CoV-2 infection.
References: PMID: 33836527 / doi: 10.1093/ilar/ilab0071
Contact Info: Caroline Zeiss: [email protected]
URL: https://academic.oup.com/ilarjournal/advance-article/doi/10.1093/ilar/ilab007/6…