Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Stanford University; University of Washington; Emory National Primate Research Center, and Emory University School of Medicine; Tulane National Primate Research Center; University of Louisiana at Lafayette; University of Maryland School of Medicine; University of California, San Diego; La Jolla Institute for Immunology; GSK; Bill and Melinda Gates Foundation; Tulane University School of Medicine;
Keywords: SARS-CoV-2, adjuvanted subunit vaccine, immune response, primates
Summary of Study: An adjuvanted subunit vaccine rsults in significant and durable memory T- and B-cell responses to Beta and Omicron variants and was found to suppress viral load and protect lungs after Omicron infection.
References: PMID: 35976993 / doi: 10.1126/scitranslmed.abq4130
Contact Info: Bali Pulendran: bpulend@stanford.edu
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abq4130?rfr_dat=cr_pub%20…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Stanford University; University of Washington; Emory National Primate Research Center, and Emory University School of Medicine; Tulane National Primate Research Center; University of Louisiana at Lafayette; University of Maryland School of Medicine; University of California, San Diego; La Jolla Institute for Immunology; GSK; Bill and Melinda Gates Foundation; Tulane University School of Medicine;
Keywords: SARS-CoV-2, adjuvanted subunit vaccine, immune response, primates
Summary of Study: An adjuvanted subunit vaccine rsults in significant and durable memory T- and B-cell responses to Beta and Omicron variants and was found to suppress viral load and protect lungs after Omicron infection.
References: PMID: 35976993 / doi: 10.1126/scitranslmed.abq4130
Contact Info: Bali Pulendran: bpulend@stanford.edu
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abq4130?rfr_dat=cr_pub%20…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: California National Primate Research Center; University of California, Davis
Keywords: SARS-CoV-2, surveillance, diagnostics, multi-antigen assays , RT-PCR, primates
Summary of Study: Colony management practices including restricted access, PPE, personnel vaccination and testing requirements have been adequate to prevent the spread of COVID-19 within the CNPRC NHP colony along with developing multi-antigen assays to survey the population.
References: PMID: 35794847 / doi: 10.1111/jmp.12604
Contact Info: JoAnn Yee: joyee@ucdavis.edu
URL: https://onlinelibrary.wiley.com/doi/10.1111/jmp.12604
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: California National Primate Research Center; University of California, Davis
Keywords: SARS-CoV-2, surveillance, diagnostics, multi-antigen assays , RT-PCR, primates
Summary of Study: Colony management practices including restricted access, PPE, personnel vaccination and testing requirements have been adequate to prevent the spread of COVID-19 within the CNPRC NHP colony along with developing multi-antigen assays to survey the population.
References: PMID: 35794847 / doi: 10.1111/jmp.12604
Contact Info: JoAnn Yee: joyee@ucdavis.edu
URL: https://onlinelibrary.wiley.com/doi/10.1111/jmp.12604
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; CureVac AG, Tübingen, Germany
Keywords: SARS-CoV-2, unmodified mRNA vaccine, CVnCoV, immune response, primates
Summary of Study: A third dose of the unmodified COVID-19 mRNA vaccine CVnCoV enhances quality and quantity of immune responses.
References: doi: 10.1016/j.omtm.2022.10.001
Contact Info: Karin Loré: karin.lore@ki.se
URL: https://www.sciencedirect.com/science/article/pii/S2329050122001437?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; CureVac AG, Tübingen, Germany
Keywords: SARS-CoV-2, unmodified mRNA vaccine, CVnCoV, immune response, primates
Summary of Study: A third dose of the unmodified COVID-19 mRNA vaccine CVnCoV enhances quality and quantity of immune responses.
References: doi: 10.1016/j.omtm.2022.10.001
Contact Info: Karin Loré: karin.lore@ki.se
URL: https://www.sciencedirect.com/science/article/pii/S2329050122001437?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chin Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, China
Keywords: SARS-CoV-2, review, traditional Chinese medicine, mice, hamsters, primates
Summary of Study: Model exploration for discovering COVID-19 targeted traditional Chinese medicine
References: doi: 10.1016/j.heliyon.2022.e12333
Contact Info: Fengmei Lian: lfm565@sohu.com
URL: https://www.sciencedirect.com/science/article/pii/S2405844022036210?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chin Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, China
Keywords: SARS-CoV-2, review, traditional Chinese medicine, mice, hamsters, primates
Summary of Study: Model exploration for discovering COVID-19 targeted traditional Chinese medicine
References: doi: 10.1016/j.heliyon.2022.e12333
Contact Info: Fengmei Lian: lfm565@sohu.com
URL: https://www.sciencedirect.com/science/article/pii/S2405844022036210?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Washington University; National Cancer Institute/NIH; Bioqual; Oak Ridge Institute of Science & Education; Columbia University Vagelos College of Physicians and Surgeons; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, spike protein ferritin nanoparticle (SpFN) vaccine, immune response, primates
Summary of Study: NHPs vaccinated with two doses of SpFN plus adjuvant separated by 28 days developed potent SARS-CoV-2-specific B and T cell responses, which conferred protection against SARS-CoV-2 challenge.
References: PMID: 34914540 / doi: 10.1126/scitranslmed.abi5735
Contact Info: Kayvon Modjarrad: kayvon.modjarrad.civ@mail.mil
URL: https://www.science.org/doi/10.1126/scitranslmed.abi5735?url_ver=Z39.88-2003&rf…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Washington University; National Cancer Institute/NIH; Bioqual; Oak Ridge Institute of Science & Education; Columbia University Vagelos College of Physicians and Surgeons; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, spike protein ferritin nanoparticle (SpFN) vaccine, immune response, primates
Summary of Study: NHPs vaccinated with two doses of SpFN plus adjuvant separated by 28 days developed potent SARS-CoV-2-specific B and T cell responses, which conferred protection against SARS-CoV-2 challenge.
References: PMID: 34914540 / doi: 10.1126/scitranslmed.abi5735
Contact Info: Kayvon Modjarrad: kayvon.modjarrad.civ@mail.mil
URL: https://www.science.org/doi/10.1126/scitranslmed.abi5735?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Zhongshan School of Medicine; Qianyang Biomedical Research Institute; Guangdong Provincial Center for Disease Control and Prevention
Keywords: SARS-CoV-2, bivalent vaccine, D614G/B.1.351, vaccine dosage, mice, primates
Summary of Study: With a prime-boost or single-dose strategy a bivalent D614G/B.1.351 RBD nanoparticle vaccine elicited robust nAbs and full protection against infection with the authentic D614 or B.1.351 strains in human ACE2 transgene mice. Furthermore, 8 months after inoculation with the D614G-specific vaccine, a new boost with this bivalent vaccine potently elicited cross-nAbs for SARS-CoV-2 variants in rhesus macaques.
References: PMID: 34990583 / doi: 10.1016/j.celrep.2021.110256
Contact Info: Yiwen Zhang: zhangyw57@mail.sysu.edu.cn; Hui Zhang: zhangh92@mail.sysu.edu.cn
URL: https://www.sciencedirect.com/science/article/pii/S221112472101768X?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Zhongshan School of Medicine; Qianyang Biomedical Research Institute; Guangdong Provincial Center for Disease Control and Prevention
Keywords: SARS-CoV-2, bivalent vaccine, D614G/B.1.351, vaccine dosage, mice, primates
Summary of Study: With a prime-boost or single-dose strategy a bivalent D614G/B.1.351 RBD nanoparticle vaccine elicited robust nAbs and full protection against infection with the authentic D614 or B.1.351 strains in human ACE2 transgene mice. Furthermore, 8 months after inoculation with the D614G-specific vaccine, a new boost with this bivalent vaccine potently elicited cross-nAbs for SARS-CoV-2 variants in rhesus macaques.
References: PMID: 34990583 / doi: 10.1016/j.celrep.2021.110256
Contact Info: Yiwen Zhang: zhangyw57@mail.sysu.edu.cn; Hui Zhang: zhangh92@mail.sysu.edu.cn
URL: https://www.sciencedirect.com/science/article/pii/S221112472101768X?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Institute de Biologie Structurale; Universite Paris-Saclay, Inserm, CEA; Amsterdam University Medical Centers; Institute Pasteur, Universite de Paris; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, vaccine candidate, synthetic spike (S) glycoprotein-coated lipid vesicles, immune response, primates
Summary of Study: Immunization of cynomolgus macaques with S coated onto lipid vesicles (S-LVs) induces high antibody titers with potent neutralizing activity against the vaccine strain, Alpha, Beta, and Gamma variants as well as T helper (Th)1 CD4+-biased T cell responses.
References: PMID: 35233549 / doi: 10.1016/j.xcrm.2022.100528
Contact Info: Winfried Weissenhorn: winfried.weissenhorn@ibs.fr; Roger Le Grand: roger.le-grand@cea.fr
URL: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00028-3?_retu…
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Institute de Biologie Structurale; Universite Paris-Saclay, Inserm, CEA; Amsterdam University Medical Centers; Institute Pasteur, Universite de Paris; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, vaccine candidate, synthetic spike (S) glycoprotein-coated lipid vesicles, immune response, primates
Summary of Study: Immunization of cynomolgus macaques with S coated onto lipid vesicles (S-LVs) induces high antibody titers with potent neutralizing activity against the vaccine strain, Alpha, Beta, and Gamma variants as well as T helper (Th)1 CD4+-biased T cell responses.
References: PMID: 35233549 / doi: 10.1016/j.xcrm.2022.100528
Contact Info: Winfried Weissenhorn: winfried.weissenhorn@ibs.fr; Roger Le Grand: roger.le-grand@cea.fr
URL: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00028-3?_retu…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; China National Center for Bioinformation; Capital Medical University; Chinese Academy of Medical Sciences and Peking Union Medical College; Huazhong University of Science & Technology
Keywords: SARS-CoV-2, transcriptomic profiling, virus replication, primates
Summary of Study: This study provides the transcriptome profiling of various tissues from the living primate host post SARS-CoV-2 infection. It illustrates that wide-spread transcriptomic changes involving diverse functions exist in multi-organs; an elevated immune response in cerebral cortex was the prominent feature atth early stage of SARS-CoV-2 infection.
References: PMID: 35377064 / doi: 10.1007/s13238-022-00915-5
Contact Info: Ying Yang: yingyang@big.ac.cn; Yun-Gui Yang: ygyang@big.ac.cn; Chuan Qin: qinchuan@pumc.edu.cn; Wei-Min Tong: wmtong@ibms.pumc.edu.cn
URL: https://link.springer.com/article/10.1007/s13238-022-00915-5
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; China National Center for Bioinformation; Capital Medical University; Chinese Academy of Medical Sciences and Peking Union Medical College; Huazhong University of Science & Technology
Keywords: SARS-CoV-2, transcriptomic profiling, virus replication, primates
Summary of Study: This study provides the transcriptome profiling of various tissues from the living primate host post SARS-CoV-2 infection. It illustrates that wide-spread transcriptomic changes involving diverse functions exist in multi-organs; an elevated immune response in cerebral cortex was the prominent feature atth early stage of SARS-CoV-2 infection.
References: PMID: 35377064 / doi: 10.1007/s13238-022-00915-5
Contact Info: Ying Yang: yingyang@big.ac.cn; Yun-Gui Yang: ygyang@big.ac.cn; Chuan Qin: qinchuan@pumc.edu.cn; Wei-Min Tong: wmtong@ibms.pumc.edu.cn
URL: https://link.springer.com/article/10.1007/s13238-022-00915-5
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Sanofi R&D; Universite de Strasbourg; Equipe 3Bio
Keywords: SARS-CoV-2, mRNA vaccine, lipid nanoparticles, stability, mice, primates
Summary of Study: The thermostability of mRNA/LNP is improved by a novel imidazole modified lipid, DOG-IM4, in combination with standard helper lipids.
References: PMID: 35576809 / doi: 10.1016/j.biomaterials.2022.121570
Contact Info: Jean Haensler: jean.haensler@sanofi.com;
URL: https://www.sciencedirect.com/science/article/pii/S0142961222002101?via%3Dihub=
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Sanofi R&D; Universite de Strasbourg; Equipe 3Bio
Keywords: SARS-CoV-2, mRNA vaccine, lipid nanoparticles, stability, mice, primates
Summary of Study: The thermostability of mRNA/LNP is improved by a novel imidazole modified lipid, DOG-IM4, in combination with standard helper lipids.
References: PMID: 35576809 / doi: 10.1016/j.biomaterials.2022.121570
Contact Info: Jean Haensler: jean.haensler@sanofi.com;
URL: https://www.sciencedirect.com/science/article/pii/S0142961222002101?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: Departments of Biochemistry and Pathology & Laboratory Medicine, Bhopal, India
Keywords: SARS-CoV-2, review, animal models, infection, pathology, primates
Summary of Study: Review of the immunological and clinical manifestations observed in various natural and genetically-modified animal models of numerous COVID-19 studies. The authors also summarize up-to-date laboratory findings on available and significant COVID-19 animal models, and put forth their perspective for the objective dependent usage of animal models.
References: PMID: 35757923 DOI: 10.1080/08830185.2022.2089666
Contact Info: Ashok Kumar: ashok.biochemistry@aiimsbhopal.edu.in
URL: https://www.tandfonline.com/doi/abs/10.1080/08830185.2022.2089666?journalCode=i…
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: Departments of Biochemistry and Pathology & Laboratory Medicine, Bhopal, India
Keywords: SARS-CoV-2, review, animal models, infection, pathology, primates
Summary of Study: Review of the immunological and clinical manifestations observed in various natural and genetically-modified animal models of numerous COVID-19 studies. The authors also summarize up-to-date laboratory findings on available and significant COVID-19 animal models, and put forth their perspective for the objective dependent usage of animal models.
References: PMID: 35757923 DOI: 10.1080/08830185.2022.2089666
Contact Info: Ashok Kumar: ashok.biochemistry@aiimsbhopal.edu.in
URL: https://www.tandfonline.com/doi/abs/10.1080/08830185.2022.2089666?journalCode=i…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Ragon Institute of MGH, MIT, and Harvard; University of Massachusetts; Bioqual
Keywords: SARS-CoV-2, adenovirus vector–based vaccine Ad26.COV2.S, immune response, primates
Summary of Study: Cytotoxic T-cells that are vaccine induced contribute to virus control, and when depleted, higher viral loads are seen in the respiratory tract.
References: PMID: 35943359 / doi: 10.1126/sciimmunol.abq7647
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.science.org/doi/full/10.1126/sciimmunol.abq7647?rfr_dat=cr_pub%20%2…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Ragon Institute of MGH, MIT, and Harvard; University of Massachusetts; Bioqual
Keywords: SARS-CoV-2, adenovirus vector–based vaccine Ad26.COV2.S, immune response, primates
Summary of Study: Cytotoxic T-cells that are vaccine induced contribute to virus control, and when depleted, higher viral loads are seen in the respiratory tract.
References: PMID: 35943359 / doi: 10.1126/sciimmunol.abq7647
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.science.org/doi/full/10.1126/sciimmunol.abq7647?rfr_dat=cr_pub%20%2…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID RNA Viruses Section, Laboratory of Infectious Diseases, numerous others
Keywords: SARS-CoV-2, pediatric vaccine, live-attenuated parainfluenza-virus-vectored vaccine, immunogenicity, primates
Summary of Study: Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine is protective in monkeys
References: doi: 10.1016/j.cell.2022.11.006
Contact Info: Ursula Buchholz: ubuchholz@niaid.nih.gov
URL: https://www.sciencedirect.com/science/article/pii/S0092867422014180?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID RNA Viruses Section, Laboratory of Infectious Diseases, numerous others
Keywords: SARS-CoV-2, pediatric vaccine, live-attenuated parainfluenza-virus-vectored vaccine, immunogenicity, primates
Summary of Study: Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine is protective in monkeys
References: doi: 10.1016/j.cell.2022.11.006
Contact Info: Ursula Buchholz: ubuchholz@niaid.nih.gov
URL: https://www.sciencedirect.com/science/article/pii/S0092867422014180?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center, Texas Biomedical Research Institute; Washington University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, longitudinal scRNAseq, bronchoalveolar lavage, immune response, primates
Summary of Study: Results unequivocally show that in protected, immunocompetent hosts, SARS-CoV-2 infection is characterized by an acute inflammatory response leading to a myeloid cell influx into the lung compartment. Induction of a robust IFN response in macrophages strongly correlates with viremia and subsequent clearance of SARS-CoV-2 from the airways of macaques.
References: PMID: 35115549 / doi: 10.1038/s41467-022-28315-7
Contact Info: Maxim Artyomov: martyomov@wustl.edu
URL: https://www.nature.com/articles/s41467-022-28315-7
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center, Texas Biomedical Research Institute; Washington University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, longitudinal scRNAseq, bronchoalveolar lavage, immune response, primates
Summary of Study: Results unequivocally show that in protected, immunocompetent hosts, SARS-CoV-2 infection is characterized by an acute inflammatory response leading to a myeloid cell influx into the lung compartment. Induction of a robust IFN response in macrophages strongly correlates with viremia and subsequent clearance of SARS-CoV-2 from the airways of macaques.
References: PMID: 35115549 / doi: 10.1038/s41467-022-28315-7
Contact Info: Maxim Artyomov: martyomov@wustl.edu
URL: https://www.nature.com/articles/s41467-022-28315-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Sun Yat-sen University; Guangdong Academy of Medical Sciences; Qianyang Biomedical Research Institute; Guangdong Provincial Center for Disease Control and Prevention
Keywords: SARS-CoV-2, Receptor Binding Domain (RBD)-Conjugated Nanoparticle Vaccine, virus variants, hACE2 mice, primates
Summary of Study: RBD-based monovalent or multivalent nanoparticle vaccines provide a promising second-generation vaccine strategy for SARS-CoV-2 variants.
References: PMID: 35142444 / doi: 10.1002/advs.202105378
Contact Info: Ting Pan: pant8@gmail.sysu.edu.cn; Hui Zhang: zhangh92@mail.sysu.edu.cn
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008796/
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Sun Yat-sen University; Guangdong Academy of Medical Sciences; Qianyang Biomedical Research Institute; Guangdong Provincial Center for Disease Control and Prevention
Keywords: SARS-CoV-2, Receptor Binding Domain (RBD)-Conjugated Nanoparticle Vaccine, virus variants, hACE2 mice, primates
Summary of Study: RBD-based monovalent or multivalent nanoparticle vaccines provide a promising second-generation vaccine strategy for SARS-CoV-2 variants.
References: PMID: 35142444 / doi: 10.1002/advs.202105378
Contact Info: Ting Pan: pant8@gmail.sysu.edu.cn; Hui Zhang: zhangh92@mail.sysu.edu.cn
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008796/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Universite Paris-Saclay, Inserm, CEA; University of Amsterdam; Grousbeck Gene Therapy Center; Harvard Medical School; The Broad Institute of Harvard and MIT; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, computed X-ray tomography and [18F]-FDG positron emission tomography, pathology, primates
Summary of Study: CT, combined with [18F]-FDG PET imaging, to study SARS-CoV-2 infected NHPs, can produce strong and transposable readouts to moitor COVID-19 disease as well as the efficacy of future treatments and vaccine candidates.
References: PMID: 35313622 / doi: 10.1016/j.isci.2022.104101
Contact Info: Thibaut Naninck: thibaut.naninck@cea.fr
URL: https://www.cell.com/iscience/fulltext/S2589-0042(22)00371-6?_returnURL=https%3…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Universite Paris-Saclay, Inserm, CEA; University of Amsterdam; Grousbeck Gene Therapy Center; Harvard Medical School; The Broad Institute of Harvard and MIT; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, computed X-ray tomography and [18F]-FDG positron emission tomography, pathology, primates
Summary of Study: CT, combined with [18F]-FDG PET imaging, to study SARS-CoV-2 infected NHPs, can produce strong and transposable readouts to moitor COVID-19 disease as well as the efficacy of future treatments and vaccine candidates.
References: PMID: 35313622 / doi: 10.1016/j.isci.2022.104101
Contact Info: Thibaut Naninck: thibaut.naninck@cea.fr
URL: https://www.cell.com/iscience/fulltext/S2589-0042(22)00371-6?_returnURL=https%3…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of California, Davis, School of Medicine
Keywords: SARS-CoV-2, pre-existing HIV infection, gene expression, metabolomics, primates
Summary of Study: SIV infection resulted in sustained or increased ACE2 expression in an inflamed and immune-impaired gut mucosal microenvironment.
References: PMID: 35495669 / doi: 10.3389/fmicb.2022.879152
Contact Info: Satya Dandekar: sdandekar@ucdavis.edu
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2022.879152/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of California, Davis, School of Medicine
Keywords: SARS-CoV-2, pre-existing HIV infection, gene expression, metabolomics, primates
Summary of Study: SIV infection resulted in sustained or increased ACE2 expression in an inflamed and immune-impaired gut mucosal microenvironment.
References: PMID: 35495669 / doi: 10.3389/fmicb.2022.879152
Contact Info: Satya Dandekar: sdandekar@ucdavis.edu
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2022.879152/full
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: The Broad Institute of Harvard and MIT; Harvard University; Universite Paris-Saclay, Inserm, CEA; Genethon INTEGRARE UMR; Rega Institute; University of Siena; University of Pennsylvania
Keywords: SARS-CoV-2, AAV-based vaccine, virus variants, immune response, mice, primates
Summary of Study: AAV-based vaccines for COVID-19 can be effective from a single, low dose and lead to durable humoral and strong T cell immunogenicity.
References: PMID: 35546782 / doi: 10.1016/j.ymthe.2022.05.007
Contact Info: Luk Vandenberghe: luk_vandenberghe@meei.harvard.edu
URL: https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-…
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: The Broad Institute of Harvard and MIT; Harvard University; Universite Paris-Saclay, Inserm, CEA; Genethon INTEGRARE UMR; Rega Institute; University of Siena; University of Pennsylvania
Keywords: SARS-CoV-2, AAV-based vaccine, virus variants, immune response, mice, primates
Summary of Study: AAV-based vaccines for COVID-19 can be effective from a single, low dose and lead to durable humoral and strong T cell immunogenicity.
References: PMID: 35546782 / doi: 10.1016/j.ymthe.2022.05.007
Contact Info: Luk Vandenberghe: luk_vandenberghe@meei.harvard.edu
URL: https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: GigaGen, Inc.; Alira Health, Inc.; Grifols S.A.; Vitalant Research Institute; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, drugs, GMP, clinical manufacturing, therapy, mice, primates
Summary of Study: A novel class of drugs, recombinant hyperimmune globulins are a safe and protective possible treatment to COVID-19 that could be made through large-scale production.
References: PMID: 35890050 / doi: 10.3390/pathogens11070806
Contact Info: Adam Adler: aadler@gigagen.com
URL: https://www.mdpi.com/2076-0817/11/7/806
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: GigaGen, Inc.; Alira Health, Inc.; Grifols S.A.; Vitalant Research Institute; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, drugs, GMP, clinical manufacturing, therapy, mice, primates
Summary of Study: A novel class of drugs, recombinant hyperimmune globulins are a safe and protective possible treatment to COVID-19 that could be made through large-scale production.
References: PMID: 35890050 / doi: 10.3390/pathogens11070806
Contact Info: Adam Adler: aadler@gigagen.com
URL: https://www.mdpi.com/2076-0817/11/7/806
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Research Institute for Biological Safety Problems, Kazakhstan
Keywords: SARS-CoV-2, inactivated vaccine, safety, immune response, several animal species, primates
Summary of Study: The first COVID-19 inactivated vaccine developed in Kazakhstan did not result in any adverse effect or change in condition of the animals' health, has high immunogenic potential, and is safe to move to clinical research.
References: PMID: 35960911 / doi: 10.1080/21645515.2022.2087412
Contact Info: Zhandos Abay: abai.zhandos15@gmail.com
URL: https://www.tandfonline.com/doi/full/10.1080/21645515.2022.2087412
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Research Institute for Biological Safety Problems, Kazakhstan
Keywords: SARS-CoV-2, inactivated vaccine, safety, immune response, several animal species, primates
Summary of Study: The first COVID-19 inactivated vaccine developed in Kazakhstan did not result in any adverse effect or change in condition of the animals' health, has high immunogenic potential, and is safe to move to clinical research.
References: PMID: 35960911 / doi: 10.1080/21645515.2022.2087412
Contact Info: Zhandos Abay: abai.zhandos15@gmail.com
URL: https://www.tandfonline.com/doi/full/10.1080/21645515.2022.2087412
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; AstraZeneca; Vanderbilt University Medical Center; Ragon Institute of MGH, MIT, and Harvard, Cambridge
Keywords: SARS-CoV-2, vaccine, bivalent monoclonal antibody, immune response, primates
Summary of Study: Using human monoclonal antibodies that target the spike glycoprotein can be administered along with viral vector-based SARS-CoV-2 vaccines without losing any effectiveness of either product.
References: PMID: 35857623 / doi: 10.1126/scitranslmed.abo6160
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abo6160?rfr_dat=cr_pub%20…
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; AstraZeneca; Vanderbilt University Medical Center; Ragon Institute of MGH, MIT, and Harvard, Cambridge
Keywords: SARS-CoV-2, vaccine, bivalent monoclonal antibody, immune response, primates
Summary of Study: Using human monoclonal antibodies that target the spike glycoprotein can be administered along with viral vector-based SARS-CoV-2 vaccines without losing any effectiveness of either product.
References: PMID: 35857623 / doi: 10.1126/scitranslmed.abo6160
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abo6160?rfr_dat=cr_pub%20…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: hhc Data Creation Center, Tsukuba Research Laboratories, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan; Drug Discovery Platform, KAN Research Institute, Inc., 6-8-2 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan; Medicine Development Center, Tsukuba Research Laboratories, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan; Department of Immunology and Parasitology, Graduate School of Medicine, Tokushima University, Tokushima 770-8503, Japan.
Keywords: SARS-CoV-2, lipid nanoparticles, encapsulated mRNA, immunogenicity, mice, primates
Summary of Study:
References: doi: 10.1016/j.omtn.2022.09.017
Contact Info: Yuta Suzuki: y14-suzuki@hhc.eisai.co.jp
URL: https://www.sciencedirect.com/science/article/pii/S2162253122002608?via%3Dihub=
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: hhc Data Creation Center, Tsukuba Research Laboratories, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan; Drug Discovery Platform, KAN Research Institute, Inc., 6-8-2 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan; Medicine Development Center, Tsukuba Research Laboratories, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan; Department of Immunology and Parasitology, Graduate School of Medicine, Tokushima University, Tokushima 770-8503, Japan.
Keywords: SARS-CoV-2, lipid nanoparticles, encapsulated mRNA, immunogenicity, mice, primates
Summary of Study:
References: doi: 10.1016/j.omtn.2022.09.017
Contact Info: Yuta Suzuki: y14-suzuki@hhc.eisai.co.jp
URL: https://www.sciencedirect.com/science/article/pii/S2162253122002608?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Duke University School of Medicine, Durham, NC; California National Primate Research Center; others.
Keywords: SARS-CoV-2, age-dependent responses, immune response, pathology, primates
Summary of Study: Age-dependent responses to SARS-CoV-2 in dam/infant pairs
References: doi: 10.4049/immunohorizons.2200075
Contact Info: Maria Blasi: maria.blasi@duke.edu
URL: https://journals.aai.org/immunohorizons/article/6/12/851/237621/Dam-Infant-Rhes…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Duke University School of Medicine, Durham, NC; California National Primate Research Center; others.
Keywords: SARS-CoV-2, age-dependent responses, immune response, pathology, primates
Summary of Study: Age-dependent responses to SARS-CoV-2 in dam/infant pairs
References: doi: 10.4049/immunohorizons.2200075
Contact Info: Maria Blasi: maria.blasi@duke.edu
URL: https://journals.aai.org/immunohorizons/article/6/12/851/237621/Dam-Infant-Rhes…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre/The Netherlands; NIAID; University Paris-Saclay, Inserm; Tulane National Primate Research Center; University of Pittsburgh School of Medicine; University of Pittsburgh Center for Vaccine Research; Texas Biomedical Research Institute; Frederick National Laboratory for Cancer Research
Keywords: SARS-CoV-2, advanced medical imaging, pathogenesis, primates
Summary of Study: The reviewers argue that advanced imaging tools add unique insight into poorly understood relationships of SARS-CV-2 exposure, infection, the host response, and disease presentation in the lungs.
References: PMID: 34955425 / doi: 10.1016/j.molmed.2021.12.001
Contact Info: Marieke Stammes: stammes@bprc.nl
URL: https://www.sciencedirect.com/science/article/pii/S1471491421003166?via%3Dihub=
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre/The Netherlands; NIAID; University Paris-Saclay, Inserm; Tulane National Primate Research Center; University of Pittsburgh School of Medicine; University of Pittsburgh Center for Vaccine Research; Texas Biomedical Research Institute; Frederick National Laboratory for Cancer Research
Keywords: SARS-CoV-2, advanced medical imaging, pathogenesis, primates
Summary of Study: The reviewers argue that advanced imaging tools add unique insight into poorly understood relationships of SARS-CV-2 exposure, infection, the host response, and disease presentation in the lungs.
References: PMID: 34955425 / doi: 10.1016/j.molmed.2021.12.001
Contact Info: Marieke Stammes: stammes@bprc.nl
URL: https://www.sciencedirect.com/science/article/pii/S1471491421003166?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine; Nanchang University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, CRISPR-RT–PCR assay, longitudinal analysis, mucosal, plasma, and breath samples, primates
Summary of Study: CRISPR-FDS may provide a means to evaluate systemic viral/viral RNA burden not detectable by RT-qPCR to improve diagnosis and better predict outcomes for SARS-CoV-2 infections.
References: PMID: 35108153 / doi: 10.1080/22221751.2038020
Contact Info: Tony Hu: tonyhu2tulane.edu
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2038020
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine; Nanchang University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, CRISPR-RT–PCR assay, longitudinal analysis, mucosal, plasma, and breath samples, primates
Summary of Study: CRISPR-FDS may provide a means to evaluate systemic viral/viral RNA burden not detectable by RT-qPCR to improve diagnosis and better predict outcomes for SARS-CoV-2 infections.
References: PMID: 35108153 / doi: 10.1080/22221751.2038020
Contact Info: Tony Hu: tonyhu2tulane.edu
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2038020
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; University of California, Irvine
Keywords: SARS-CoV-2, Vesicular Stomatitis Virus-Based Vaccine, route of administration, immune response, primates
Summary of Study: The VSV-SARS2-EBOV vaccine presents a vaccine with a high potential as a boosting option after the already-approved mRNA-based vaccine, because VSV-SARS2-EBOV elicits primarily a humoral response, in contrast to the predominantly T cell-driven immune response after mRNA vaccination.
References: PMID: 35012339 / doi: 10.1128/mbio.03379-21
Contact Info: Andrea Marzi: marzia@niaid.nih.gov
URL: https://journals.asm.org/doi/full/10.1128/mbio.03379-21?rfr_dat=cr_pub%20%200pu…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; University of California, Irvine
Keywords: SARS-CoV-2, Vesicular Stomatitis Virus-Based Vaccine, route of administration, immune response, primates
Summary of Study: The VSV-SARS2-EBOV vaccine presents a vaccine with a high potential as a boosting option after the already-approved mRNA-based vaccine, because VSV-SARS2-EBOV elicits primarily a humoral response, in contrast to the predominantly T cell-driven immune response after mRNA vaccination.
References: PMID: 35012339 / doi: 10.1128/mbio.03379-21
Contact Info: Andrea Marzi: marzia@niaid.nih.gov
URL: https://journals.asm.org/doi/full/10.1128/mbio.03379-21?rfr_dat=cr_pub%20%200pu…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Institute of Infectious Diseases, Tokyo; Kumamoto University; ID Pharma Co., Ltd.
Keywords: SARS-CoV-2, intranasal vaccine, non-S antigens, immune response, primates
Summary of Study: CD8+ T cell induction by intranasal vaccination with a vaccine expressing viral non-S antigens can result in NAb-independent control of SARS-CoV-2 infection.
References: PMID: 35233545 / doi: 10.1016/j.xcrm.2022.100520
Contact Info: Tetsuro Matano: tmatano@nih.go.jp
URL: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00020-9?_retu…
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Institute of Infectious Diseases, Tokyo; Kumamoto University; ID Pharma Co., Ltd.
Keywords: SARS-CoV-2, intranasal vaccine, non-S antigens, immune response, primates
Summary of Study: CD8+ T cell induction by intranasal vaccination with a vaccine expressing viral non-S antigens can result in NAb-independent control of SARS-CoV-2 infection.
References: PMID: 35233545 / doi: 10.1016/j.xcrm.2022.100520
Contact Info: Tetsuro Matano: tmatano@nih.go.jp
URL: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00020-9?_retu…
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Illinois College of Medicine
Keywords: SARS-CoV-2, transcriptomic profiling, lung endothelial cells, primates
Summary of Study: The specific genes that distinguished immuneEC and devEC populations in the NHP lungs after SARS-CoV-2 infection were different from the endotoxemic mouse lung. This may reflect either species differences or different injury-specific responses (bacterial endotoxin vs. SARS-CoV-2).
References: PMID: 35511435 / doi: 10.1172/jci.insight.158079
Contact Info: Lianghui Zhang: lhzhang@uic.edu; Jalees Rehman: jalees@uic.edu
URL: https://insight.jci.org/articles/view/158079
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Illinois College of Medicine
Keywords: SARS-CoV-2, transcriptomic profiling, lung endothelial cells, primates
Summary of Study: The specific genes that distinguished immuneEC and devEC populations in the NHP lungs after SARS-CoV-2 infection were different from the endotoxemic mouse lung. This may reflect either species differences or different injury-specific responses (bacterial endotoxin vs. SARS-CoV-2).
References: PMID: 35511435 / doi: 10.1172/jci.insight.158079
Contact Info: Lianghui Zhang: lhzhang@uic.edu; Jalees Rehman: jalees@uic.edu
URL: https://insight.jci.org/articles/view/158079
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Fred Hutchinson Cancer Research Center; Department of Medicine, University of Washington
Keywords: SARS-CoV-2, remdesivir, math modeling, antiviral potency, nasal passages, lungs, primates
Summary of Study: In rhesus macaques, the nonlinear forces governing SARS-CoV-2 viral load trajectories in the lung and nasal passages differ substantially in the presence of a partially effective antiviral therapy. To the extent that the rhesus macaque model approximates human infection, nasal viral load remains a promising surrogate endpoint marker but perhaps only in the context of a highly potent antiviral therapy.
References: PMID: 35634576 / doi: 10.1016/j.isci.2022.104448
Contact Info: Joshua Schiffer: jschiffe@fredhutch.org
URL: https://www.cell.com/iscience/fulltext/S2589-0042(22)00719-2?_returnURL=https%3…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Fred Hutchinson Cancer Research Center; Department of Medicine, University of Washington
Keywords: SARS-CoV-2, remdesivir, math modeling, antiviral potency, nasal passages, lungs, primates
Summary of Study: In rhesus macaques, the nonlinear forces governing SARS-CoV-2 viral load trajectories in the lung and nasal passages differ substantially in the presence of a partially effective antiviral therapy. To the extent that the rhesus macaque model approximates human infection, nasal viral load remains a promising surrogate endpoint marker but perhaps only in the context of a highly potent antiviral therapy.
References: PMID: 35634576 / doi: 10.1016/j.isci.2022.104448
Contact Info: Joshua Schiffer: jschiffe@fredhutch.org
URL: https://www.cell.com/iscience/fulltext/S2589-0042(22)00719-2?_returnURL=https%3…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shionogi & Co., Ltd.; Department of Pathology and Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan
Keywords: SARS-CoV-2, recombinant S-protein vaccine S-268019-b, immune response, primates
Summary of Study: Immunogenicity and protective efficacy of SARS-CoV-2 recombinant S-protein vaccine S-268019-b in cynomolgus monkeys
References: PMID: 35691872 PMCID: PMC9167832 DOI: 10.1016/j.vaccine.22.05.081
Contact Info: Hideki Hasegawa: hasegawa@niid.go.jp
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22007186?via%3Dihub=
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shionogi & Co., Ltd.; Department of Pathology and Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan
Keywords: SARS-CoV-2, recombinant S-protein vaccine S-268019-b, immune response, primates
Summary of Study: Immunogenicity and protective efficacy of SARS-CoV-2 recombinant S-protein vaccine S-268019-b in cynomolgus monkeys
References: PMID: 35691872 PMCID: PMC9167832 DOI: 10.1016/j.vaccine.22.05.081
Contact Info: Hideki Hasegawa: hasegawa@niid.go.jp
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22007186?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shanghai Zerun Biotech Co., Ltd.; numerous others
Keywords: SARS-CoV-2, recombinant vaccine, immunogenicity, virus variants, hamster, primates
Summary of Study: A potent, broadly protective vaccine against SARS-CoV-2 variants of concern.
References: doi: 10.1038/s41541-022-00571-0
Contact Info: Chenliang Zhou: zhouchenliang@wallvax.com
URL: https://www.nature.com/articles/s41541-022-00571-0
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shanghai Zerun Biotech Co., Ltd.; numerous others
Keywords: SARS-CoV-2, recombinant vaccine, immunogenicity, virus variants, hamster, primates
Summary of Study: A potent, broadly protective vaccine against SARS-CoV-2 variants of concern.
References: doi: 10.1038/s41541-022-00571-0
Contact Info: Chenliang Zhou: zhouchenliang@wallvax.com
URL: https://www.nature.com/articles/s41541-022-00571-0
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences; Fudan University; Shanghai King-Cell Biotechnology Co., Ltd.; Mabwell Bioscience Co., Ltd.; Shenzhen University; University of Chinese Academy of Sciences
Keywords: SARS-CoV-2, self-adjuvating peptide vaccine, CoVac501, immune response, virus variants, primates
Summary of Study: CoVac501, a novel SARS-CoV-2 vaccine that is fully chemically synthesized and self-adjuvanting, provided potent protecton for cynomolgus macaques against challenges from very high doses of SARS-CoV-2.
References: PMID: 35102138 / doi: 10.1038/s41421-021-00370-2
Contact Info: Qiuping Qin: pqqin@cdser.simm.ac.cn
URL: https://www.nature.com/articles/s41421-021-00370-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences; Fudan University; Shanghai King-Cell Biotechnology Co., Ltd.; Mabwell Bioscience Co., Ltd.; Shenzhen University; University of Chinese Academy of Sciences
Keywords: SARS-CoV-2, self-adjuvating peptide vaccine, CoVac501, immune response, virus variants, primates
Summary of Study: CoVac501, a novel SARS-CoV-2 vaccine that is fully chemically synthesized and self-adjuvanting, provided potent protecton for cynomolgus macaques against challenges from very high doses of SARS-CoV-2.
References: PMID: 35102138 / doi: 10.1038/s41421-021-00370-2
Contact Info: Qiuping Qin: pqqin@cdser.simm.ac.cn
URL: https://www.nature.com/articles/s41421-021-00370-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Pfizer; Icahn School of Medicine at Mount Sinai; Texas Biomedical Research Institute; New Iberia Research Center
Keywords: SARS-CoV-2, pathology, inflammation, Golden Syrian Hamster, primates
Summary of Study: Macaques may be appropriate for mechanistic studies of mild asymptomatic COVID-19 pneumonia and COVID-19-associated encephalitis, whereas Syrian hamsters may be more suited to study severe COVID-19 pneumonia.
References: PMID: 35128980 / doi: 10.1177/01926233211072767
Contact Info: Shambhunath Choudhary: shambhunath.choudhary@pfizer.com
URL: https://journals.sagepub.com/doi/full/10.1177/01926233211072767?rfr_dat=cr_pub%…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Pfizer; Icahn School of Medicine at Mount Sinai; Texas Biomedical Research Institute; New Iberia Research Center
Keywords: SARS-CoV-2, pathology, inflammation, Golden Syrian Hamster, primates
Summary of Study: Macaques may be appropriate for mechanistic studies of mild asymptomatic COVID-19 pneumonia and COVID-19-associated encephalitis, whereas Syrian hamsters may be more suited to study severe COVID-19 pneumonia.
References: PMID: 35128980 / doi: 10.1177/01926233211072767
Contact Info: Shambhunath Choudhary: shambhunath.choudhary@pfizer.com
URL: https://journals.sagepub.com/doi/full/10.1177/01926233211072767?rfr_dat=cr_pub%…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; Tongji Medical College of Huazhong University of Science & Technology
Keywords: SARS-CoV-2, infection, pathogenesis, virus variants, primates
Summary of Study: Delta variant of SARS-CoV-2 can effectively infect the Rhesus macaque.
References: PMID: 35279412 / doi: 10.1016/j.virs.2022.02.001
Contact Info: Zhiming Yuan: yzm@wh.iov.cn; Chao Shan: shanchao@wh.iov.cn
URL: https://www.sciencedirect.com/science/article/pii/S1995820X22000335?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; Tongji Medical College of Huazhong University of Science & Technology
Keywords: SARS-CoV-2, infection, pathogenesis, virus variants, primates
Summary of Study: Delta variant of SARS-CoV-2 can effectively infect the Rhesus macaque.
References: PMID: 35279412 / doi: 10.1016/j.virs.2022.02.001
Contact Info: Zhiming Yuan: yzm@wh.iov.cn; Chao Shan: shanchao@wh.iov.cn
URL: https://www.sciencedirect.com/science/article/pii/S1995820X22000335?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Fred Hutchinson Cancer Research Center; University of Washington; HDT Bio; NIAID; Washington National Primate Research Center
Keywords: SARS-CoV-2, phage-based deep mutational scanning, immune response, vaccination, primates
Summary of Study: Findings suggest that the antibody response to SARS-CoV-2 in macaques shares many features with humans, but with substantial differences in the recognition of certain epitopes and considerable individual variability in antibody escape profiles, suggesting a diverse repertoire of antibodies that can respond to major epitopes in both humans and macaques.
References: PMID: 35404959 / doi: 10.1371/journal.ppat.1010155
Contact Info: Julie Overbaugh: joverbau@fredhutch.org
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010155
NHP Species: pigtail macaques, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Fred Hutchinson Cancer Research Center; University of Washington; HDT Bio; NIAID; Washington National Primate Research Center
Keywords: SARS-CoV-2, phage-based deep mutational scanning, immune response, vaccination, primates
Summary of Study: Findings suggest that the antibody response to SARS-CoV-2 in macaques shares many features with humans, but with substantial differences in the recognition of certain epitopes and considerable individual variability in antibody escape profiles, suggesting a diverse repertoire of antibodies that can respond to major epitopes in both humans and macaques.
References: PMID: 35404959 / doi: 10.1371/journal.ppat.1010155
Contact Info: Julie Overbaugh: joverbau@fredhutch.org
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010155
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: USAMRIID; Henry M. Jackson Foundation for the Advancement of Military Medicine; Walter Reed Army Institute of Research
Keywords: SARS-CoV-2, spike ferritin nanoparticle vaccine, immune response, primates
Summary of Study: Two adjuvants were compared (ALFQ and AIOH3): Robust humoral and cellular immunological responses were observed for vaccinated animals, with the ALFQ-adjuvanted group generating a significantly higher response compared ot the AIOH3 group. Vaccination with either adjuvant resulted in fewer clinical signs of disease compared to controls, including a significant reduction in lesions and virus replication in the lungs.
References: PMID: 35632473 / doi: 10.3390/vaccines10050717
Contact Info: Jeffrey Smith: jeffrey.smith@fda.hhs.gov; Jay Hooper: jay.w.hooper.civ@mail.mil; Keersten Ricks: keersten.m.ricks.civ@mail.mil; Hannah King: hanna.king@nih.gov; Kristina Peachman: kpeachman@hivresearch.org; Alexandra Jay: alexandra.n.jay.civ@mail.mil
URL: https://www.mdpi.com/2076-393X/10/5/717
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: USAMRIID; Henry M. Jackson Foundation for the Advancement of Military Medicine; Walter Reed Army Institute of Research
Keywords: SARS-CoV-2, spike ferritin nanoparticle vaccine, immune response, primates
Summary of Study: Two adjuvants were compared (ALFQ and AIOH3): Robust humoral and cellular immunological responses were observed for vaccinated animals, with the ALFQ-adjuvanted group generating a significantly higher response compared ot the AIOH3 group. Vaccination with either adjuvant resulted in fewer clinical signs of disease compared to controls, including a significant reduction in lesions and virus replication in the lungs.
References: PMID: 35632473 / doi: 10.3390/vaccines10050717
Contact Info: Jeffrey Smith: jeffrey.smith@fda.hhs.gov; Jay Hooper: jay.w.hooper.civ@mail.mil; Keersten Ricks: keersten.m.ricks.civ@mail.mil; Hannah King: hanna.king@nih.gov; Kristina Peachman: kpeachman@hivresearch.org; Alexandra Jay: alexandra.n.jay.civ@mail.mil
URL: https://www.mdpi.com/2076-393X/10/5/717
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses; Jilin University First Hospital; Beijing Institute of Biotechnology; College of Basic Medical Sciences; Zhongshan Hospital Fudan University; Beijing Institute of Microbiology and Epidemiology; Shaanxi Normal University
Keywords: SARS-CoV-2, proteomics, metabolomics, pathology, immune response, primates
Summary of Study: An established COVID-19 model demonstrates that the innate immune response, neutrophil and platelet activation were dysregulated in infected NHPs, and these were greatly weakened in the most infected NHPs, which models moderately infected humans.
References: PMID: 35903092 / doi: 10.3389/fimmu.2022.954121
Contact Info: Yuwei Gao: yuwei0901@outlook.com; Yan Liu: liu820512@163.com; Xiaochang Xue: xuexch@snnu.edu.cn; Hui Wang: geno0109@vip.sina.com
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.954121/full
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses; Jilin University First Hospital; Beijing Institute of Biotechnology; College of Basic Medical Sciences; Zhongshan Hospital Fudan University; Beijing Institute of Microbiology and Epidemiology; Shaanxi Normal University
Keywords: SARS-CoV-2, proteomics, metabolomics, pathology, immune response, primates
Summary of Study: An established COVID-19 model demonstrates that the innate immune response, neutrophil and platelet activation were dysregulated in infected NHPs, and these were greatly weakened in the most infected NHPs, which models moderately infected humans.
References: PMID: 35903092 / doi: 10.3389/fimmu.2022.954121
Contact Info: Yuwei Gao: yuwei0901@outlook.com; Yan Liu: liu820512@163.com; Xiaochang Xue: xuexch@snnu.edu.cn; Hui Wang: geno0109@vip.sina.com
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.954121/full
Coronavirus Investigated: SARS-CoV-1, SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: The Scripps Research Institute; Massachusetts Institute of Technology; Alpha Genesis; University of California, San Diego; La Jolla Institute for Immunology; Howard Hughes Medical Institute; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University
Keywords: SARS-CoV-2, SARS-CoV-1, comparative studies, immune response, primates
Summary of Study: Using a two-shot protocol immunization with SARS-CoV-2 spike protein created strong serum receptor binding domain neutralizing antibody responses to both SARS-CoV-1 and SARS-CoV-2.
References: PMID: 35947674 / doi: 10.1126/scitranslmed.abl9605
Contact Info: Ian Wilson: wilson@scripps.edu; Dennis Burton: burton@scripps.edu; Raiees Andrabi: andrabi@scripps.edu
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abl9605?rfr_dat=cr_pub%20…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: The Scripps Research Institute; Massachusetts Institute of Technology; Alpha Genesis; University of California, San Diego; La Jolla Institute for Immunology; Howard Hughes Medical Institute; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University
Keywords: SARS-CoV-2, SARS-CoV-1, comparative studies, immune response, primates
Summary of Study: Using a two-shot protocol immunization with SARS-CoV-2 spike protein created strong serum receptor binding domain neutralizing antibody responses to both SARS-CoV-1 and SARS-CoV-2.
References: PMID: 35947674 / doi: 10.1126/scitranslmed.abl9605
Contact Info: Ian Wilson: wilson@scripps.edu; Dennis Burton: burton@scripps.edu; Raiees Andrabi: andrabi@scripps.edu
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abl9605?rfr_dat=cr_pub%20…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences & Peking Union Medical College; Beijing Engineering Research Center of Protein and Antibody, Sinocelltech Ltd
Keywords: SARS-CoV-2, nebulized neutralizing antibody, inhalation, mice, primates
Summary of Study: Feasibility of nebulized antibodies inhalation delivery
References: doi: 10.1007/s11095-022-03340-9
Contact Info: LX@sinocelltech.com
URL: https://link.springer.com/article/10.1007/s11095-022-03340-9
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences & Peking Union Medical College; Beijing Engineering Research Center of Protein and Antibody, Sinocelltech Ltd
Keywords: SARS-CoV-2, nebulized neutralizing antibody, inhalation, mice, primates
Summary of Study: Feasibility of nebulized antibodies inhalation delivery
References: doi: 10.1007/s11095-022-03340-9
Contact Info: LX@sinocelltech.com
URL: https://link.springer.com/article/10.1007/s11095-022-03340-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: Gujarat Biotechnology Research Centre (GBRC), India; Kamdhenu University, Gujarat, India; University of California Santa Barbara, Santa Barbara, CA.
Keywords: SARS-CoV-2, surveillance, RT-PCR, several animal species, primates
Summary of Study: Highlights transmission of SARS-CoV-2 infection from human to animals and suggests being watchful for zoonosis.
References: doi: 10.3390/ijerph192114391
Contact Info: Arunkumar Patel: viroarun@gmail.com
URL: https://www.mdpi.com/1660-4601/19/21/14391
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: Gujarat Biotechnology Research Centre (GBRC), India; Kamdhenu University, Gujarat, India; University of California Santa Barbara, Santa Barbara, CA.
Keywords: SARS-CoV-2, surveillance, RT-PCR, several animal species, primates
Summary of Study: Highlights transmission of SARS-CoV-2 infection from human to animals and suggests being watchful for zoonosis.
References: doi: 10.3390/ijerph192114391
Contact Info: Arunkumar Patel: viroarun@gmail.com
URL: https://www.mdpi.com/1660-4601/19/21/14391
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane School of Medicine
Keywords: SARS-CoV-2, aerosol or intra-tracheal/intra-nasal infection, viral load, inflammation, primates
Summary of Study: Cellular mechanisms underlying acute respiratory distress syndrome
References: doi: 10.1038/s42003-022-04310-y
Contact Info: Namita Rout: nrout@tulane.edu
URL: https://www.nature.com/articles/s42003-022-04310-y
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane School of Medicine
Keywords: SARS-CoV-2, aerosol or intra-tracheal/intra-nasal infection, viral load, inflammation, primates
Summary of Study: Cellular mechanisms underlying acute respiratory distress syndrome
References: doi: 10.1038/s42003-022-04310-y
Contact Info: Namita Rout: nrout@tulane.edu
URL: https://www.nature.com/articles/s42003-022-04310-y
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Emory University; University of Sao Paulo School of Medicine; Butantan Institute; La Jolla Institute for Immunology
Keywords: SARS-CoV-2, DNA vaccine HIVBr18, HLA class II vaccine epitopes, immunity, humans and primates
Summary of Study: Results provide preliminary proof of concept that immunization with a vaccine encoding epitopes with high and redundant coverage of the human population can elicit potent T cell responses to multiple epitopes, across species and MHC barriers.
References: PMID: 34961636 / doi: 10.1016/j.vaccine.2021.11.076
Contact Info: Edecio Cunha-Neto: edecunha@usp.br
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21015504?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Emory University; University of Sao Paulo School of Medicine; Butantan Institute; La Jolla Institute for Immunology
Keywords: SARS-CoV-2, DNA vaccine HIVBr18, HLA class II vaccine epitopes, immunity, humans and primates
Summary of Study: Results provide preliminary proof of concept that immunization with a vaccine encoding epitopes with high and redundant coverage of the human population can elicit potent T cell responses to multiple epitopes, across species and MHC barriers.
References: PMID: 34961636 / doi: 10.1016/j.vaccine.2021.11.076
Contact Info: Edecio Cunha-Neto: edecunha@usp.br
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21015504?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medicine Sciences & Peking Union Medical College; National Institute for Viral Disease Control and Prevention
Keywords: SARS-CoV-2, heterologous vaccines, intradermal administration, immune response, primates
Summary of Study: This study reports a new heeterologous prime-boost strategy of intradermal immunization with the inactivated vaccine and K-S antigen. This strategy can significantly increase the neutralizing antibody titers and promote specific T cell responses in mice and macaques.
References: PMID: 34931939 / doi: 10.1080/22221751.2021807https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
Contact Info: Wenbo Xu: wenbo_xu1@aliyun.com; Qihan Li: liqihan@imbcams.com.cn
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medicine Sciences & Peking Union Medical College; National Institute for Viral Disease Control and Prevention
Keywords: SARS-CoV-2, heterologous vaccines, intradermal administration, immune response, primates
Summary of Study: This study reports a new heeterologous prime-boost strategy of intradermal immunization with the inactivated vaccine and K-S antigen. This strategy can significantly increase the neutralizing antibody titers and promote specific T cell responses in mice and macaques.
References: PMID: 34931939 / doi: 10.1080/22221751.2021807https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
Contact Info: Wenbo Xu: wenbo_xu1@aliyun.com; Qihan Li: liqihan@imbcams.com.cn
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine
Keywords: SARS-CoV-2, virus genome, gut, virus evolution, primates
Summary of Study: Previous reports that an intact furin cleavage site is important for infection in vivo were confirmed in this study. Additionally, three mutations were identified that may represent an adaptation of SARS-CoV2 to African green monkeys or to NHP generally.
References: PMID: 35062281 / doi: 10.3390/v14010077
Contact Info: Nicholas Maness: nmaness@tulane.edu
URL: https://www.mdpi.com/1999-4915/14/1/77
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine
Keywords: SARS-CoV-2, virus genome, gut, virus evolution, primates
Summary of Study: Previous reports that an intact furin cleavage site is important for infection in vivo were confirmed in this study. Additionally, three mutations were identified that may represent an adaptation of SARS-CoV2 to African green monkeys or to NHP generally.
References: PMID: 35062281 / doi: 10.3390/v14010077
Contact Info: Nicholas Maness: nmaness@tulane.edu
URL: https://www.mdpi.com/1999-4915/14/1/77
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Shanghai Jiao Tong University; Westlake University, Hangzhou; University of Texas; Jecho Biopharmaceuticals; Jecho Laboratories; Zhengzhou University People's Hospital
Keywords: SARS-CoV-2, virus variants, neutralizing monoclonal antibodies, immune reponse, mice, primates
Summary of Study: An antibody designated as 2G1 efficiently neutralized all VOCs including widely spread Alpha, Beta, Gamma, Delta variants and Cluster 5, a variant with Y453F substitution that once caused public concern due to its zoonotic characteristics.
References: PMID: 35169121 / doi: 10.1038/s41421-022-00381-7
Contact Info: Lei Han: lei.han@jechobio.com
URL: https://www.nature.com/articles/s41421-022-00381-7
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Shanghai Jiao Tong University; Westlake University, Hangzhou; University of Texas; Jecho Biopharmaceuticals; Jecho Laboratories; Zhengzhou University People's Hospital
Keywords: SARS-CoV-2, virus variants, neutralizing monoclonal antibodies, immune reponse, mice, primates
Summary of Study: An antibody designated as 2G1 efficiently neutralized all VOCs including widely spread Alpha, Beta, Gamma, Delta variants and Cluster 5, a variant with Y453F substitution that once caused public concern due to its zoonotic characteristics.
References: PMID: 35169121 / doi: 10.1038/s41421-022-00381-7
Contact Info: Lei Han: lei.han@jechobio.com
URL: https://www.nature.com/articles/s41421-022-00381-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Peking University; Chinese Academy of Medical Sciences and Peking Union Medical College; WHO Collaborating Center for Standardization and Evaluation of Biologicals
Keywords: SARS-CoV-2, circRNA vaccine, neutralizing antibodies, virus variants, primates
Summary of Study: CircRNA/RBD-Omicron vaccine induced effective neutralizing antibodies against the Omicron but not the Delta variant. In contrast, the circRNA/RBD-Delta vaccine protected against both Delta and Omicron or functioned as a booster after two doses of either native- or Delta-specific vaccination, making it a favorable choice against the current variants of concern of SARS-CoV-2.
References: PMID: 35460644 / doi: 10.1016/j.cell.2022.03.044
Contact Info: Wensheng Wei: wswei@pku.edu.cn
URL: https://www.cell.com/cell/fulltext/S0092-8674(22)00394-4?_returnURL=https%3A//l…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Peking University; Chinese Academy of Medical Sciences and Peking Union Medical College; WHO Collaborating Center for Standardization and Evaluation of Biologicals
Keywords: SARS-CoV-2, circRNA vaccine, neutralizing antibodies, virus variants, primates
Summary of Study: CircRNA/RBD-Omicron vaccine induced effective neutralizing antibodies against the Omicron but not the Delta variant. In contrast, the circRNA/RBD-Delta vaccine protected against both Delta and Omicron or functioned as a booster after two doses of either native- or Delta-specific vaccination, making it a favorable choice against the current variants of concern of SARS-CoV-2.
References: PMID: 35460644 / doi: 10.1016/j.cell.2022.03.044
Contact Info: Wensheng Wei: wswei@pku.edu.cn
URL: https://www.cell.com/cell/fulltext/S0092-8674(22)00394-4?_returnURL=https%3A//l…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: SUNY Upstate Medical University; Walter Reed Army Institute of Research; NIAID
Keywords: SARS-CoV-2, mRNA-1273 vaccine, respiratory tract, inflammation, primates
Summary of Study: This study defines the lower respiratory tract cellular and transcriptional signature associated with SARS-CoV-2 in macaques using two distinct viral variants, and identifies conserved signatures of vaccine-elicited protection from infection-attendant inflammation. These date emphasize the contribution of inflammatory/migratory DCs and macrophages to lower respiratory tract inflammation following SARS-CoV-2 infection, and define a critical relationship between antibody titers, post-challenge viral burden, and broad infection-elicited inflammation.
References: PMID: 35653196 / doi: 10.1172/jci.insight.160039
Contact Info: Robert Seder: Robert Seder: rseder@mail.nih.gov
URL: https://insight.jci.org/articles/view/160039
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: SUNY Upstate Medical University; Walter Reed Army Institute of Research; NIAID
Keywords: SARS-CoV-2, mRNA-1273 vaccine, respiratory tract, inflammation, primates
Summary of Study: This study defines the lower respiratory tract cellular and transcriptional signature associated with SARS-CoV-2 in macaques using two distinct viral variants, and identifies conserved signatures of vaccine-elicited protection from infection-attendant inflammation. These date emphasize the contribution of inflammatory/migratory DCs and macrophages to lower respiratory tract inflammation following SARS-CoV-2 infection, and define a critical relationship between antibody titers, post-challenge viral burden, and broad infection-elicited inflammation.
References: PMID: 35653196 / doi: 10.1172/jci.insight.160039
Contact Info: Robert Seder: Robert Seder: rseder@mail.nih.gov
URL: https://insight.jci.org/articles/view/160039
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: CAS Key Laboratory of Computational Biology; Shanghai Institute of Nutrition and Health; University of Chinese Academy of Sciences; Chinese Academy of Sciences; Max Planck Institute of Psychiatry, Proteomics and Biomarkers
Keywords: SARS-CoV-2, circadian gene networks, transcriptome, primates
Summary of Study: Many mammalian genes are controlled by a central clock under circadian control, resulting in a rhythmic expression of genes involved in homeostasis. SARS-CoV-2 related genes are also rhythmically expressed, suggesting close interactions with circadian regulators.
References: PMID: 35906476 / doi: 10.1038/s42003-022-03722-0
Contact Info: Guang-Zhong Wang: guangzhong.wang@picb.ac.cn
URL: https://www.nature.com/articles/s42003-022-03722-0
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: CAS Key Laboratory of Computational Biology; Shanghai Institute of Nutrition and Health; University of Chinese Academy of Sciences; Chinese Academy of Sciences; Max Planck Institute of Psychiatry, Proteomics and Biomarkers
Keywords: SARS-CoV-2, circadian gene networks, transcriptome, primates
Summary of Study: Many mammalian genes are controlled by a central clock under circadian control, resulting in a rhythmic expression of genes involved in homeostasis. SARS-CoV-2 related genes are also rhythmically expressed, suggesting close interactions with circadian regulators.
References: PMID: 35906476 / doi: 10.1038/s42003-022-03722-0
Contact Info: Guang-Zhong Wang: guangzhong.wang@picb.ac.cn
URL: https://www.nature.com/articles/s42003-022-03722-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Institutes for Food and Drug Control, Beijing; Guangzhou Laboratory; Kunming National High-level Biosafety Primate Research Center
Keywords: SARS-CoV-2, vaccine, chimpanzee adenovirus vector, immune response, mice, primates
Summary of Study: Using a chimpanzee adenovirus vectored vaccine expressing SARS-CoV2 spike in combination with an inactivated vaccine reduced lung injury risk while maintaining flexibility of the antibody regulation system.
References: PMID: 36059554 / doi: 10.3389/fimmu.2022.949248
Contact Info: Junzhi Wang: wangjz@nifdc.org.cn; Zhenglun Liang: lzhenglun@126.com; Miao Xu: xumiao@nifdc.org.cn
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.949248/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Institutes for Food and Drug Control, Beijing; Guangzhou Laboratory; Kunming National High-level Biosafety Primate Research Center
Keywords: SARS-CoV-2, vaccine, chimpanzee adenovirus vector, immune response, mice, primates
Summary of Study: Using a chimpanzee adenovirus vectored vaccine expressing SARS-CoV2 spike in combination with an inactivated vaccine reduced lung injury risk while maintaining flexibility of the antibody regulation system.
References: PMID: 36059554 / doi: 10.3389/fimmu.2022.949248
Contact Info: Junzhi Wang: wangjz@nifdc.org.cn; Zhenglun Liang: lzhenglun@126.com; Miao Xu: xumiao@nifdc.org.cn
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.949248/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane University, Memorial Sloan Kettering Cancer Ctr, Weill Cornell Medical College, Instuto de Química Pontificia Universidad Católica de Valparaíso
Keywords: SARS-CoV-2, urokinase plasminogen activator receptor, renal dysfunction, pathology, primates
Summary of Study: Elevated soluble urokinase plasminogen activator receptor
References: doi: 10.1111/jmp.12626
Contact Info: Minolfa Prieto: mprieto@tulane.edu
URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/jmp.12626
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane University, Memorial Sloan Kettering Cancer Ctr, Weill Cornell Medical College, Instuto de Química Pontificia Universidad Católica de Valparaíso
Keywords: SARS-CoV-2, urokinase plasminogen activator receptor, renal dysfunction, pathology, primates
Summary of Study: Elevated soluble urokinase plasminogen activator receptor
References: doi: 10.1111/jmp.12626
Contact Info: Minolfa Prieto: mprieto@tulane.edu
URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/jmp.12626
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; Gilead Sciences
Keywords: SARS-CoV-2, Remdesivir, subcutaneous administration, pathology, virus load, primates
Summary of Study: Early subcutaneous administration of remdesivir can protect from lower respiratory tract disease caused by SARS-CoV-2.
References: PMID: 35032523 / doi: 10.1016/j.antiviral.2022.105246
Contact Info: Emmie de Wit: emmie.dewit@nih.gov
URL: https://www.sciencedirect.com/science/article/pii/S0166354222000146?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; Gilead Sciences
Keywords: SARS-CoV-2, Remdesivir, subcutaneous administration, pathology, virus load, primates
Summary of Study: Early subcutaneous administration of remdesivir can protect from lower respiratory tract disease caused by SARS-CoV-2.
References: PMID: 35032523 / doi: 10.1016/j.antiviral.2022.105246
Contact Info: Emmie de Wit: emmie.dewit@nih.gov
URL: https://www.sciencedirect.com/science/article/pii/S0166354222000146?via%3Dihub=