Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Clover Biopharmaceuticals, Kunming Institute of Zoology
Keywords: SARS-CoV-2, S-Trimer, subunit vaccine candidate, immunogenicity, efficacy, primates
Summary of Study: Rhesus macaques immunized with adjuvanted S-Trimer were protected from SARS-CoV-2 challenge. Trimer-Tag may be an important platform technology for scalable production and rapid development of safe and effective subunit vaccines against current and future emerging RNA viruses.
References: PMID: 33649323 / doi: 10.1038/s41467-021-21634-1
Contact Info: Peng Liang: [email protected]
URL: https://www.nature.com/articles/s41467-021-21634-1
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Clover Biopharmaceuticals, Kunming Institute of Zoology
Keywords: SARS-CoV-2, S-Trimer, subunit vaccine candidate, immunogenicity, efficacy, primates
Summary of Study: Rhesus macaques immunized with adjuvanted S-Trimer were protected from SARS-CoV-2 challenge. Trimer-Tag may be an important platform technology for scalable production and rapid development of safe and effective subunit vaccines against current and future emerging RNA viruses.
References: PMID: 33649323 / doi: 10.1038/s41467-021-21634-1
Contact Info: Peng Liang: [email protected]
URL: https://www.nature.com/articles/s41467-021-21634-1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Beth Israel Deaconess Medical Center, MIT, Harvard
Keywords: SARS-CoV-2, DNA- and Ad26-based vaccines, serum profiles, primates
Summary of Study: Data highlight the similarities between infection and vaccine induced humoral immunity for SARS-Cov-2 and cross-reactivity of these responses to other CoVs.
References: PMID: 33692201 / doi: 10.1128/JVI.00117-21
Contact Info: Dan Barouch: [email protected]
URL: https://journals.asm.org/doi/10.1128/JVI.00117-21?url_ver=Z39.88-2003&rfr_id=or…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Beth Israel Deaconess Medical Center, MIT, Harvard
Keywords: SARS-CoV-2, DNA- and Ad26-based vaccines, serum profiles, primates
Summary of Study: Data highlight the similarities between infection and vaccine induced humoral immunity for SARS-Cov-2 and cross-reactivity of these responses to other CoVs.
References: PMID: 33692201 / doi: 10.1128/JVI.00117-21
Contact Info: Dan Barouch: [email protected]
URL: https://journals.asm.org/doi/10.1128/JVI.00117-21?url_ver=Z39.88-2003&rfr_id=or…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Ragon Institute of MGH, MIT, and Harvard; Novavax; University of Duisburg-Essen; MIT; Texas Biomedical Research Institute; University of Maryland School of Medicine; Duke University Medical Center; La Jolla Institute for Immunology; and others
Keywords: SARS-CoV-2, humoral immune response, vaccine-induced antibody fingerprint, protection, primates
Summary of Study: Data presented suggest that a single dose may prevent disease via combined Fc/Fab functions but that two doses may be essential to block further transmission of SARS-CoV-2 and emerging variants.
References: PMID: 34485950 / doi: 10.1016/j.xcrm.2021.100405
Contact Info: Gale Smith: [email protected]; Galit Alter: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009701
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Ragon Institute of MGH, MIT, and Harvard; Novavax; University of Duisburg-Essen; MIT; Texas Biomedical Research Institute; University of Maryland School of Medicine; Duke University Medical Center; La Jolla Institute for Immunology; and others
Keywords: SARS-CoV-2, humoral immune response, vaccine-induced antibody fingerprint, protection, primates
Summary of Study: Data presented suggest that a single dose may prevent disease via combined Fc/Fab functions but that two doses may be essential to block further transmission of SARS-CoV-2 and emerging variants.
References: PMID: 34485950 / doi: 10.1016/j.xcrm.2021.100405
Contact Info: Gale Smith: [email protected]; Galit Alter: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009701
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Janssen Vaccines & Prevention B.V.; Harvard Medical School; Lucidity Biomedical Consulting; Ragon Institute of MGH, MIT and Harvard; Massachusetts Consortium on Pathogen Readiness
Keywords: SARS-CoV-2, adenovirus vector, immunogenicity, protective efficacy, immune response, primates
Summary of Study: Ad26.COV2.S vaccine confers durable protection against replication of SARS-CoV-2 in the lungs that is predicted by the levels of Spike-binding and neutralizing antibodies, indicating that Ad26.COV2.S could confer durable protection in humans and immunological correlates of protection may enable the prediction of durability of protection.
References: PMID: 34620860 / doi: 10.1038/s41467-021-26117-x
Contact Info: Roland Zahn: [email protected]
URL: https://www.nature.com/articles/s41467-021-26117-x
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Janssen Vaccines & Prevention B.V.; Harvard Medical School; Lucidity Biomedical Consulting; Ragon Institute of MGH, MIT and Harvard; Massachusetts Consortium on Pathogen Readiness
Keywords: SARS-CoV-2, adenovirus vector, immunogenicity, protective efficacy, immune response, primates
Summary of Study: Ad26.COV2.S vaccine confers durable protection against replication of SARS-CoV-2 in the lungs that is predicted by the levels of Spike-binding and neutralizing antibodies, indicating that Ad26.COV2.S could confer durable protection in humans and immunological correlates of protection may enable the prediction of durability of protection.
References: PMID: 34620860 / doi: 10.1038/s41467-021-26117-x
Contact Info: Roland Zahn: [email protected]
URL: https://www.nature.com/articles/s41467-021-26117-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: SW National Primate Research Center, Washington University School of Medicine, Texas Biomedical Research Institute, Tulane University
Keywords: SARS-CoV-2, single-cell RNA sequencing. Immune response, primates
Summary of Study: The recruitment of a myeloid-cell-mediated Type I IFN response is associated with the rapid clearance of SARS-CoV-2 infection in macaques.
References: PMID: 34282414 / doi: 10.21203/rs.3.rs-664507/v1
Contact Info: Deepak Kaushal: [email protected]
URL: https://www.researchsquare.com/article/rs-664507/v1
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: SW National Primate Research Center, Washington University School of Medicine, Texas Biomedical Research Institute, Tulane University
Keywords: SARS-CoV-2, single-cell RNA sequencing. Immune response, primates
Summary of Study: The recruitment of a myeloid-cell-mediated Type I IFN response is associated with the rapid clearance of SARS-CoV-2 infection in macaques.
References: PMID: 34282414 / doi: 10.21203/rs.3.rs-664507/v1
Contact Info: Deepak Kaushal: [email protected]
URL: https://www.researchsquare.com/article/rs-664507/v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Public Health England; University of Oxford; Oxford University Hospitals NHS Foundation Trust; Quadram Institute Bioscience
Keywords: SARS-CoV-2, inactivated vaccine, vaccine-enhanced disease, pathology, ferrets, primates
Summary of Study: Studies assessed the potential for VED (vaccine-enhanced disease) in animals vaccinated with formaldehyde-inactivated SARS-CoV-2 formulated with Alhydrogel, compared to a negative control vaccine. No evidence of enhanced disease was shown in ferrets of rhesus macaques except for mild transient enhanced disease seen 7 days after infection in ferrets. This was resolved by day 15.
References: PMID: 34516768 / doi: 10.1126/sciadv.abg7996
Contact Info: Miles Carol: [email protected]; Andrew Gorringe: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.abg7996?url_ver=Z39.88-2003&rfr_id=o…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Public Health England; University of Oxford; Oxford University Hospitals NHS Foundation Trust; Quadram Institute Bioscience
Keywords: SARS-CoV-2, inactivated vaccine, vaccine-enhanced disease, pathology, ferrets, primates
Summary of Study: Studies assessed the potential for VED (vaccine-enhanced disease) in animals vaccinated with formaldehyde-inactivated SARS-CoV-2 formulated with Alhydrogel, compared to a negative control vaccine. No evidence of enhanced disease was shown in ferrets of rhesus macaques except for mild transient enhanced disease seen 7 days after infection in ferrets. This was resolved by day 15.
References: PMID: 34516768 / doi: 10.1126/sciadv.abg7996
Contact Info: Miles Carol: [email protected]; Andrew Gorringe: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.abg7996?url_ver=Z39.88-2003&rfr_id=o…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre (BPRC, Netherlands), Utrecht University
Keywords: SARS-CoV-2, computed tomography, bronchoalveolar lavage, test interference, primates
Summary of Study: Thorax CTs were evaluated for alterations in lung density in health and experimentally SARS-CoV-infected female rhesus macaques before and after bronchoalveolar lavage (BAL). An increase in the lung density was observed on the post-BAL CT but resolved within 24 hours in the healthy animals; a significant difference in both the lung density and CT score was still found 24 hours post BAL in the infected animals.
References: PMID: 34242213 / doi: 10.1371/journal.pone.0252941
Contact Info: Marieke Stammes: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0252941
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre (BPRC, Netherlands), Utrecht University
Keywords: SARS-CoV-2, computed tomography, bronchoalveolar lavage, test interference, primates
Summary of Study: Thorax CTs were evaluated for alterations in lung density in health and experimentally SARS-CoV-infected female rhesus macaques before and after bronchoalveolar lavage (BAL). An increase in the lung density was observed on the post-BAL CT but resolved within 24 hours in the healthy animals; a significant difference in both the lung density and CT score was still found 24 hours post BAL in the infected animals.
References: PMID: 34242213 / doi: 10.1371/journal.pone.0252941
Contact Info: Marieke Stammes: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0252941
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, ACE2 expression, transcription factor AhR, pathology, primates
Summary of Study: Data in this study show that the transcription factor AhR is able to bind the promoter of the ACE2 gene, thus promoting ACE2 expression and augmenting the subsequent pathology in SARS-CoV-2-infected lungs.
References: PMID: 33795851 / doi: 10.1038/s41423-021-00672-1
Contact Info: Chuan Qin: [email protected]; Bo Huang: [email protected]
URL: https://www.nature.com/articles/s41423-021-00672-1
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, ACE2 expression, transcription factor AhR, pathology, primates
Summary of Study: Data in this study show that the transcription factor AhR is able to bind the promoter of the ACE2 gene, thus promoting ACE2 expression and augmenting the subsequent pathology in SARS-CoV-2-infected lungs.
References: PMID: 33795851 / doi: 10.1038/s41423-021-00672-1
Contact Info: Chuan Qin: [email protected]; Bo Huang: [email protected]
URL: https://www.nature.com/articles/s41423-021-00672-1
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Yale School of Medicine, Johns Hopkins School of Medicine
Keywords: SARS-CoV-2, ACE2, several animal species, immune response, pathology, primates
Summary of Study: This review summarized key clinical, radiologic, and pathologic features of human COVID-19, followed by a comparison with spontaneous and genetically altered animal models of SARS-CoV-2 infection.
References: PMID: 33836527 / doi: 10.1093/ilar/ilab0071
Contact Info: Caroline Zeiss: [email protected]
URL: https://academic.oup.com/ilarjournal/advance-article/doi/10.1093/ilar/ilab007/6…
NHP Species: african green monkeys, rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Yale School of Medicine, Johns Hopkins School of Medicine
Keywords: SARS-CoV-2, ACE2, several animal species, immune response, pathology, primates
Summary of Study: This review summarized key clinical, radiologic, and pathologic features of human COVID-19, followed by a comparison with spontaneous and genetically altered animal models of SARS-CoV-2 infection.
References: PMID: 33836527 / doi: 10.1093/ilar/ilab0071
Contact Info: Caroline Zeiss: [email protected]
URL: https://academic.oup.com/ilarjournal/advance-article/doi/10.1093/ilar/ilab007/6…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: The Wistar Institute; Inovio Pharmaceuticals; Bioqual
Keywords: SARS-CoV-2, DNA vaccine, immunogenicity, immune response, adaptive immune response, primates
Summary of Study: INO-4800, an intradermal-delivered SARS-CoV-2 spike DNA vaccine, induced both humoral and cellular arms of the adaptive immune system.
References: PMID: 34604818 / doi: 10.1016/j.xcrm.2021.100420
Contact Info: Kate Broderick: [email protected]; David Weiner: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379121002822?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: The Wistar Institute; Inovio Pharmaceuticals; Bioqual
Keywords: SARS-CoV-2, DNA vaccine, immunogenicity, immune response, adaptive immune response, primates
Summary of Study: INO-4800, an intradermal-delivered SARS-CoV-2 spike DNA vaccine, induced both humoral and cellular arms of the adaptive immune system.
References: PMID: 34604818 / doi: 10.1016/j.xcrm.2021.100420
Contact Info: Kate Broderick: [email protected]; David Weiner: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379121002822?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Shiga University of Medical Science, Otsu, Japan
Keywords: SARS-CoV-2, severe acute respiratory syndrome, immune response, primates
Summary of Study: Cynomolgus macaques infected with SARS-CoV-2 showed body temperature rises and X-ray radiographic pneumonia without life-threatening clinical signs of disease. Because of similar symptoms to approximately 80% of patients, cynomolgus macaques are appropriate to extrapolate the efficacy of vaccines and antiviral drugs for humans.
References: PMID: 33412411/doi: 10.1016/j.virol.2020.12.013
Contact Info: Yasushi Itoh (no contact information)
URL: https://www.sciencedirect.com/science/article/pii/S0042682220302609?via%3Dihub=
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Shiga University of Medical Science, Otsu, Japan
Keywords: SARS-CoV-2, severe acute respiratory syndrome, immune response, primates
Summary of Study: Cynomolgus macaques infected with SARS-CoV-2 showed body temperature rises and X-ray radiographic pneumonia without life-threatening clinical signs of disease. Because of similar symptoms to approximately 80% of patients, cynomolgus macaques are appropriate to extrapolate the efficacy of vaccines and antiviral drugs for humans.
References: PMID: 33412411/doi: 10.1016/j.virol.2020.12.013
Contact Info: Yasushi Itoh (no contact information)
URL: https://www.sciencedirect.com/science/article/pii/S0042682220302609?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane NPRC, North Carolina State University
Keywords: SARS-CoV-2, portable, ultrasensitive saliva-based virus assay, primates
Summary of Study: CRISPR-FDS determined that mean SARS-Cov-2 RNA levels were 3.6 fold to 124-fold higher, and more stable, in oropharyngeal versus nasal swab samples from nonhuman primates at all time points after infection, suggesting that saliva may represent a more robust diagnostic sample than nasal swabs both early and later in infection.
References: PMID: 33310733 / doi: 10.1126/sciadv.abe3703
Contact Info: Tony Hu: [email protected]
URL: https://advances.sciencemag.org/content/7/2/eabe3703
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane NPRC, North Carolina State University
Keywords: SARS-CoV-2, portable, ultrasensitive saliva-based virus assay, primates
Summary of Study: CRISPR-FDS determined that mean SARS-Cov-2 RNA levels were 3.6 fold to 124-fold higher, and more stable, in oropharyngeal versus nasal swab samples from nonhuman primates at all time points after infection, suggesting that saliva may represent a more robust diagnostic sample than nasal swabs both early and later in infection.
References: PMID: 33310733 / doi: 10.1126/sciadv.abe3703
Contact Info: Tony Hu: [email protected]
URL: https://advances.sciencemag.org/content/7/2/eabe3703
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: NCI/NIH
Keywords: SARS-CoV-2, ACE2, type I interferon, pathology, primates
Summary of Study: Type I interferon mediates an important innate immune response against viral infection by directly inhibiting viral replication. It also bridges innate to adaptive immunity for long-term protection against viral reinfections.
References: PMID: 34149696 / doi: 10.3389/fimmu.2021.658428
Contact Info: Yongjun Sui: [email protected]; Jay Berzofsky: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.658428/full
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: NCI/NIH
Keywords: SARS-CoV-2, ACE2, type I interferon, pathology, primates
Summary of Study: Type I interferon mediates an important innate immune response against viral infection by directly inhibiting viral replication. It also bridges innate to adaptive immunity for long-term protection against viral reinfections.
References: PMID: 34149696 / doi: 10.3389/fimmu.2021.658428
Contact Info: Yongjun Sui: [email protected]; Jay Berzofsky: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.658428/full
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Amsterdam; University Paris-Saclay, Inserm, CEA; AIMM Therapeutics BV; J&S Preclinical Solutions; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, variants of concern, third vaccination, mice, rabbits, primates
Summary of Study: A third immunization improves neutralizing antibody titers against the variants-of-concern (Alpha, Beta, Gamma, and Delta).
References: PMID: 34862406 / doi: 10.1038/s41541-021-00411-7
Contact Info: Rogier Sanders: [email protected]
URL: https://www.nature.com/articles/s41541-021-00411-7
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Amsterdam; University Paris-Saclay, Inserm, CEA; AIMM Therapeutics BV; J&S Preclinical Solutions; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, variants of concern, third vaccination, mice, rabbits, primates
Summary of Study: A third immunization improves neutralizing antibody titers against the variants-of-concern (Alpha, Beta, Gamma, and Delta).
References: PMID: 34862406 / doi: 10.1038/s41541-021-00411-7
Contact Info: Rogier Sanders: [email protected]
URL: https://www.nature.com/articles/s41541-021-00411-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of California-Davis; California National Primate Research Center, UC Davis; Chan Zuckerberg Biohub; Vitalant Research Institute; University of Wisconsin-Madison; Wisconsin National Primate Research Center/UW Madison; University of California-San Francisco
Keywords: SARS-CoV-2, convalescent plasma, viral shedding, treatment efficiency, primates
Summary of Study: Passive immunization with convalescent plasma (CP), even during early infection, provided no significant benefit in a nonhuman primate model of SARS-CoV-2 infection.
References: PMID: 34817208 / doi: 10.1128/Spectrum.01397-21
Contact Info: Jesse Deere: [email protected]
URL: https://journals.asm.org/doi/10.1128/Spectrum.01397-21
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of California-Davis; California National Primate Research Center, UC Davis; Chan Zuckerberg Biohub; Vitalant Research Institute; University of Wisconsin-Madison; Wisconsin National Primate Research Center/UW Madison; University of California-San Francisco
Keywords: SARS-CoV-2, convalescent plasma, viral shedding, treatment efficiency, primates
Summary of Study: Passive immunization with convalescent plasma (CP), even during early infection, provided no significant benefit in a nonhuman primate model of SARS-CoV-2 infection.
References: PMID: 34817208 / doi: 10.1128/Spectrum.01397-21
Contact Info: Jesse Deere: [email protected]
URL: https://journals.asm.org/doi/10.1128/Spectrum.01397-21
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Qassim University, Buraydah, Saudi Aribia; Imam Abdulrahman Bin Faisal University, MGM Dental College and Hospital, Baba Farid University of Health Sciences, Himachal Institute of Dental Sciences, Panineeya Mahavidyalaya
Keywords: SARS-CoV-2, immune response, animal models, meta analysis, mice, hamsters, ferrets, cats, dogs, primates
Summary of Study: This systematic review found that animal models only mimic limited signs and symptoms experienced in COVID infection as compared to infections in humans, yet are still essential to understand the pathogenesis, transmissibility or viral particles, and vaccine testing.
References: PMID: 34447038 / doi: 10.4103/jpbs.JPBS_749_20
Contact Info: Muhamood Moothedath: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375911/
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Qassim University, Buraydah, Saudi Aribia; Imam Abdulrahman Bin Faisal University, MGM Dental College and Hospital, Baba Farid University of Health Sciences, Himachal Institute of Dental Sciences, Panineeya Mahavidyalaya
Keywords: SARS-CoV-2, immune response, animal models, meta analysis, mice, hamsters, ferrets, cats, dogs, primates
Summary of Study: This systematic review found that animal models only mimic limited signs and symptoms experienced in COVID infection as compared to infections in humans, yet are still essential to understand the pathogenesis, transmissibility or viral particles, and vaccine testing.
References: PMID: 34447038 / doi: 10.4103/jpbs.JPBS_749_20
Contact Info: Muhamood Moothedath: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375911/
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Brigham and Women's Hospital and Harvard Medical School, The Affiliated Hospital of Youjiang Medical Univ. for Nationalities (China), and the University of Alabama
Keywords: SARS-CoV-2, ACE2 protein expression, lung injury, mice and primates
Summary of Study: Data from this study unequivocally support the key role of ACE2 in the sinonasal mucosa as a functional reARS-CoV-2; however, the restricted baseline expression pattern of ACE1 in the lung presents a conundrum as it raises questions about alternative viral receptors or additional mechanisms of lung injury in COVID-19 pneumonia.
References: PMID: 33626084 / doi: 10.1371/journal.pone.0247510
Contact Info: Sule Cataltepe: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0247510
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Brigham and Women's Hospital and Harvard Medical School, The Affiliated Hospital of Youjiang Medical Univ. for Nationalities (China), and the University of Alabama
Keywords: SARS-CoV-2, ACE2 protein expression, lung injury, mice and primates
Summary of Study: Data from this study unequivocally support the key role of ACE2 in the sinonasal mucosa as a functional reARS-CoV-2; however, the restricted baseline expression pattern of ACE1 in the lung presents a conundrum as it raises questions about alternative viral receptors or additional mechanisms of lung injury in COVID-19 pneumonia.
References: PMID: 33626084 / doi: 10.1371/journal.pone.0247510
Contact Info: Sule Cataltepe: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0247510
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Tsinghua University School of Medicine; Chinese Academy of Sciences; Peking Union Medical College, The University of Hong Kong, and more
Keywords: SARS-CoV-2, adenovirus vector, vaccine candidate, immune response, hamsters, mice, primates
Summary of Study: ADC68, a rare chimpanzee adenovirus serotype, was used as a vector for vaccine and induced potent and protective immune responses against SARS-CoV-2 in experimental animals, providing scientific rationale for further developing ADC68-19S as a clinical vaccine against SARS-CoV-2 infection in humans.
References: PMID: 34262569 / doi: 10.3389/fimmu.2021.697074
Contact Info: Zhiwei Chen: [email protected]; Xioxhong Peng: [email protected]; Dongming Zhou: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.697074/full
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Tsinghua University School of Medicine; Chinese Academy of Sciences; Peking Union Medical College, The University of Hong Kong, and more
Keywords: SARS-CoV-2, adenovirus vector, vaccine candidate, immune response, hamsters, mice, primates
Summary of Study: ADC68, a rare chimpanzee adenovirus serotype, was used as a vector for vaccine and induced potent and protective immune responses against SARS-CoV-2 in experimental animals, providing scientific rationale for further developing ADC68-19S as a clinical vaccine against SARS-CoV-2 infection in humans.
References: PMID: 34262569 / doi: 10.3389/fimmu.2021.697074
Contact Info: Zhiwei Chen: [email protected]; Xioxhong Peng: [email protected]; Dongming Zhou: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.697074/full
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chulalongkorn University, Mahidol University, Baiya Phytopharm Co., National Center for Genetic Engineering and Biotechnology
Keywords: SARS-CoV-2, plant-produced receptor-binding domain, immune response, primates
Summary of Study: The plant-based protein RBD-Fc was shown to be immunogenic and significantly boosted a humoral and cell-mediated immune response in both mice and cynomolgus macaques. This protein has the potential for use as a vaccine candidate against SARS-CoV-2.
References: PMID: 34054909 / doi: 10.3389/fpls.2021.682953
Contact Info: Waranyoo Phoolcharoen: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158422/
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chulalongkorn University, Mahidol University, Baiya Phytopharm Co., National Center for Genetic Engineering and Biotechnology
Keywords: SARS-CoV-2, plant-produced receptor-binding domain, immune response, primates
Summary of Study: The plant-based protein RBD-Fc was shown to be immunogenic and significantly boosted a humoral and cell-mediated immune response in both mice and cynomolgus macaques. This protein has the potential for use as a vaccine candidate against SARS-CoV-2.
References: PMID: 34054909 / doi: 10.3389/fpls.2021.682953
Contact Info: Waranyoo Phoolcharoen: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158422/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: DSO National Laboratories, Singapore; University of Texas Medical Branch; Hummingbird Bioscience; and others
Keywords: SARS-CoV-2, neutralizing antibodies, immune response, hamsters and primates
Summary of Study: SC31, a potent SARS-CoV-2 neutralizing antibody isolated from a convalescent patient, demonstrated therapeutic efficacy in three different models.
References: PMID: 34161386 / doi: 10.1371/journal.pone.0253487
Contact Info: Brendon John Hanson: [email protected]; Trevor Brasel: [email protected]; Piers J. Ingram: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0253487
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: DSO National Laboratories, Singapore; University of Texas Medical Branch; Hummingbird Bioscience; and others
Keywords: SARS-CoV-2, neutralizing antibodies, immune response, hamsters and primates
Summary of Study: SC31, a potent SARS-CoV-2 neutralizing antibody isolated from a convalescent patient, demonstrated therapeutic efficacy in three different models.
References: PMID: 34161386 / doi: 10.1371/journal.pone.0253487
Contact Info: Brendon John Hanson: [email protected]; Trevor Brasel: [email protected]; Piers J. Ingram: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0253487
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Public Health England, Inovio Pharmaceuticals, Oxford University
Keywords: SARS-CoV-2, synthetic DNA vaccine candidate, immune response, primates
Summary of Study: The results in a stringent preclinical SARS-CoV-2 animal model provide further support for the efficacy and safety of the synthetic DNA vaccine INO-4800 as a prophylactic countermeasure against COVID-19.
References: PMID: 34253420 / doi: 10.1016/j.vaccine.2021.06.057
Contact Info: Kate Broderick (Inovio Pharmaceuticals, Inc.; Miles Carroll (Public Health England)
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21008070?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Public Health England, Inovio Pharmaceuticals, Oxford University
Keywords: SARS-CoV-2, synthetic DNA vaccine candidate, immune response, primates
Summary of Study: The results in a stringent preclinical SARS-CoV-2 animal model provide further support for the efficacy and safety of the synthetic DNA vaccine INO-4800 as a prophylactic countermeasure against COVID-19.
References: PMID: 34253420 / doi: 10.1016/j.vaccine.2021.06.057
Contact Info: Kate Broderick (Inovio Pharmaceuticals, Inc.; Miles Carroll (Public Health England)
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21008070?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Iowa; University of Florida
Keywords: SARS-CoV-2, meta analysis, airway mucus, mucin glycoproteins, inflammation, primates
Summary of Study: Ferrets, nonhuman primates, and cats may have advantages over other models to investigate mucus in COVID-19.
References: PMID: 34794359 / doi: 10.1177/03009858211058837
Contact Info: not available
URL: https://journals.sagepub.com/doi/10.1177/03009858211058837?url_ver=Z39.88-2003&…
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Iowa; University of Florida
Keywords: SARS-CoV-2, meta analysis, airway mucus, mucin glycoproteins, inflammation, primates
Summary of Study: Ferrets, nonhuman primates, and cats may have advantages over other models to investigate mucus in COVID-19.
References: PMID: 34794359 / doi: 10.1177/03009858211058837
Contact Info: not available
URL: https://journals.sagepub.com/doi/10.1177/03009858211058837?url_ver=Z39.88-2003&…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Emory University School of Medicine
Keywords: SARS-CoV-2, several animal species, anti-viral therapeutic, vaccine development, primates
Summary of Study: Summarizing key features, strengths and weaknesses of animal models for SARS-CoV-2, focusing on their application in anti-viral therapeutic and vaccine development.
References: PMID: 33906125 / doi: 10.1016/j.coviro.2021.03.009
Contact Info: Anice Lowen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1879625721000316?via%3Dihub=
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Emory University School of Medicine
Keywords: SARS-CoV-2, several animal species, anti-viral therapeutic, vaccine development, primates
Summary of Study: Summarizing key features, strengths and weaknesses of animal models for SARS-CoV-2, focusing on their application in anti-viral therapeutic and vaccine development.
References: PMID: 33906125 / doi: 10.1016/j.coviro.2021.03.009
Contact Info: Anice Lowen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1879625721000316?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chungbuk National University
Keywords: SARS-CoV-2, several animal species, transduction, pathology, primates
Summary of Study: Review of various animal models employed for SARS-CoV-2 infection studies that outlines their individual strengths and limitations for use in studies aimed at increasing understanding of coronavirus pathogenesis.
References: PMID: 33996168 / doi: 10.4110/in.2021.21.e12
Contact Info: Young Ki Choi: [email protected]
URL: https://immunenetwork.org/DOIx.php?id=10.4110/in.2021.21.e12
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chungbuk National University
Keywords: SARS-CoV-2, several animal species, transduction, pathology, primates
Summary of Study: Review of various animal models employed for SARS-CoV-2 infection studies that outlines their individual strengths and limitations for use in studies aimed at increasing understanding of coronavirus pathogenesis.
References: PMID: 33996168 / doi: 10.4110/in.2021.21.e12
Contact Info: Young Ki Choi: [email protected]
URL: https://immunenetwork.org/DOIx.php?id=10.4110/in.2021.21.e12
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, cryopreservation, resources, genetic diversity, primates
Summary of Study: The importance of rhesus macaques as a preclinical model for human diseases and treatment outcomes supports the development of improved cryopreservation methods and routine storage of gametes and embryos.
References: PMID: 34031599 / doi: 10.1038/s41684-021-00792-1
Contact Info: Matthew Arnegard: [email protected]
URL: https://www.nature.com/articles/s41684-021-00792-1
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, cryopreservation, resources, genetic diversity, primates
Summary of Study: The importance of rhesus macaques as a preclinical model for human diseases and treatment outcomes supports the development of improved cryopreservation methods and routine storage of gametes and embryos.
References: PMID: 34031599 / doi: 10.1038/s41684-021-00792-1
Contact Info: Matthew Arnegard: [email protected]
URL: https://www.nature.com/articles/s41684-021-00792-1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Akston Biosciences Corp.; Biomere Biomedical Research Models; Feigin ABSL-3 Facility, Baylor College of Medicine; BIOQUAL; California National Primate Research Center; Sinclair Research Center; Pharmaceutical Research Associates Group B.V.
Keywords: SARS-CoV-2, viral spike protein, immunogenicity, prophylaxis, Fc-fusion, mice, primates
Summary of Study: Preclinical studies support the initiation of Phase I clinical studies with adjuvanted AKS-452 with the expectation that this room-temperature stable, Fc-fusion subunit vaccine can be rapidly and inexpensively manufactured to provide billions of doses per year especially in regions where the cold-chain is difficult to maintain.
References: PMID: 34642088 / doi: 10.1016/j.vaccine.2021.09.077
Contact Info: Todd Zion: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21012949?via%3Dihub=
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Akston Biosciences Corp.; Biomere Biomedical Research Models; Feigin ABSL-3 Facility, Baylor College of Medicine; BIOQUAL; California National Primate Research Center; Sinclair Research Center; Pharmaceutical Research Associates Group B.V.
Keywords: SARS-CoV-2, viral spike protein, immunogenicity, prophylaxis, Fc-fusion, mice, primates
Summary of Study: Preclinical studies support the initiation of Phase I clinical studies with adjuvanted AKS-452 with the expectation that this room-temperature stable, Fc-fusion subunit vaccine can be rapidly and inexpensively manufactured to provide billions of doses per year especially in regions where the cold-chain is difficult to maintain.
References: PMID: 34642088 / doi: 10.1016/j.vaccine.2021.09.077
Contact Info: Todd Zion: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21012949?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: ReiThera Srl, University of Nottingham, National Institute for Infectious Diseases "Lazzaro Spallanzani"
Keywords: SARS-CoV-2, replication-defective gorilla adenovirus-vectored vaccine, immune response, mice and primates
Summary of Study: Pre-fusion stabilized Spike antigen is superior to the wild type in inducing ACE2-interfering, SARS-CoV-2-neutralizing antibodies.
References: PMID: 33895322 / doi: 10.1016/j.ymthe.2021.04.022
Contact Info: Alessandra Vitelli: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1525001621002100?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: ReiThera Srl, University of Nottingham, National Institute for Infectious Diseases "Lazzaro Spallanzani"
Keywords: SARS-CoV-2, replication-defective gorilla adenovirus-vectored vaccine, immune response, mice and primates
Summary of Study: Pre-fusion stabilized Spike antigen is superior to the wild type in inducing ACE2-interfering, SARS-CoV-2-neutralizing antibodies.
References: PMID: 33895322 / doi: 10.1016/j.ymthe.2021.04.022
Contact Info: Alessandra Vitelli: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1525001621002100?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Duke University School of Medicine, University of North Carolina at Chapel Hill, FDA, and others
Keywords: SARS-CoV-2, nanoparticles, receptor-binding domain of SARS-CoV-2, immune response, primates
Summary of Study: The immunization of macaques with nanoparticles conjugated with the receptor-binding domain of SARS-CoV-2, and adjuvanted with 3M-052 and alum, elicits cross-neutralizing antibody responses against bat coronaviruses, SARS-CoV and SARS-CoV-2. Nucleoside-modified mRNAs that encode a stabilized transmembrane spike or monomeric receptor-binding domain also induced cross-neutralizing antibody responses against SARS-CoV and bat coronaviruses.
References: PMID: 33971664 / doi: 10.1038/s41586-021-03594-0
Contact Info: Kevin Saunders: [email protected]; Barton Haynes: [email protected]
URL: https://www.nature.com/articles/s41586-021-03594-0
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Duke University School of Medicine, University of North Carolina at Chapel Hill, FDA, and others
Keywords: SARS-CoV-2, nanoparticles, receptor-binding domain of SARS-CoV-2, immune response, primates
Summary of Study: The immunization of macaques with nanoparticles conjugated with the receptor-binding domain of SARS-CoV-2, and adjuvanted with 3M-052 and alum, elicits cross-neutralizing antibody responses against bat coronaviruses, SARS-CoV and SARS-CoV-2. Nucleoside-modified mRNAs that encode a stabilized transmembrane spike or monomeric receptor-binding domain also induced cross-neutralizing antibody responses against SARS-CoV and bat coronaviruses.
References: PMID: 33971664 / doi: 10.1038/s41586-021-03594-0
Contact Info: Kevin Saunders: [email protected]; Barton Haynes: [email protected]
URL: https://www.nature.com/articles/s41586-021-03594-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID; Emory University; BIOQUAL, Inc.; Moderna, Inc.; Johns Hopkins University
Keywords: SARS-CoV-2, virus genomic variants, boost, immune response, primates
Summary of Study: Homologous mRNA-1273 boost can significantly improve both the breadth and potency of neutralizing antibody responses and confer protection against upper and lower airway infection to a heterologous challenge virus, which is relatively resistant to in vitro neutralization.
References: PMID: 34672695 / doi: 10.1126/science.abl8912
Contact Info: Robert Seder: [email protected]; Barney Graham: [email protected]
URL: https://www.science.org/doi/10.1126/science.abl8912?url_ver=Z39.88-2003&rfr_id=…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID; Emory University; BIOQUAL, Inc.; Moderna, Inc.; Johns Hopkins University
Keywords: SARS-CoV-2, virus genomic variants, boost, immune response, primates
Summary of Study: Homologous mRNA-1273 boost can significantly improve both the breadth and potency of neutralizing antibody responses and confer protection against upper and lower airway infection to a heterologous challenge virus, which is relatively resistant to in vitro neutralization.
References: PMID: 34672695 / doi: 10.1126/science.abl8912
Contact Info: Robert Seder: [email protected]; Barney Graham: [email protected]
URL: https://www.science.org/doi/10.1126/science.abl8912?url_ver=Z39.88-2003&rfr_id=…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIH, University of Oxford, NIAID, Icahn School of Medicine at Mount Sinai
Keywords: SARS-CoV-2, adenovirus-based vaccine, intranasal administration, hamsters, primates
Summary of Study: Intranasal vaccination with ChAdOx1 nCoV-19/AZD1222 reduced virus concentrations in nasal swabs in two different SARS-CoV-2 animal models, warranting further investigation as a potential vaccination route for COVID-19 vaccines.
References: PMID: 34315826 / doi: 10.1126/scitranslmed.abh0755
Contact Info: Vincent Munster: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abh0755?url_ver=Z39.88-2003&rf…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIH, University of Oxford, NIAID, Icahn School of Medicine at Mount Sinai
Keywords: SARS-CoV-2, adenovirus-based vaccine, intranasal administration, hamsters, primates
Summary of Study: Intranasal vaccination with ChAdOx1 nCoV-19/AZD1222 reduced virus concentrations in nasal swabs in two different SARS-CoV-2 animal models, warranting further investigation as a potential vaccination route for COVID-19 vaccines.
References: PMID: 34315826 / doi: 10.1126/scitranslmed.abh0755
Contact Info: Vincent Munster: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abh0755?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Johns Hopkins School of Medicine; Yale University School of Medicine
Keywords: SARS-CoV-2, several animal species, immunological response, primates
Summary of Study: This review discusses small and large animal model studies previously used in SARS-CoV-2 research that may be useful in elucidating the immunological contributions to hallmark syndromes observed with COVID-19.
References: PMID: 33914873 / doi: 10.1093/ilar/ilab010
Contact Info: Rebecca Veenhuis: [email protected]
URL: https://academic.oup.com/ilarjournal/advance-article/doi/10.1093/ilar/ilab010/6…
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Johns Hopkins School of Medicine; Yale University School of Medicine
Keywords: SARS-CoV-2, several animal species, immunological response, primates
Summary of Study: This review discusses small and large animal model studies previously used in SARS-CoV-2 research that may be useful in elucidating the immunological contributions to hallmark syndromes observed with COVID-19.
References: PMID: 33914873 / doi: 10.1093/ilar/ilab010
Contact Info: Rebecca Veenhuis: [email protected]
URL: https://academic.oup.com/ilarjournal/advance-article/doi/10.1093/ilar/ilab010/6…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Universite de Paris, Institut Pasteur and others
Keywords: SARS-CoV-2, mathematical model, viral dynamics, immune response, viral clearance, primates
Summary of Study: Results provide estimates of SARS-CoV-2 viral kinetic parameters in an experimental model of mild infection and they provide means to assess the efficacy of future antiviral treatments.
References: PMID: 33730053 / doi: 10.1371/journal.pcbi.1008785
Contact Info: Antonio Goncalves: [email protected]
URL: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008785
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Universite de Paris, Institut Pasteur and others
Keywords: SARS-CoV-2, mathematical model, viral dynamics, immune response, viral clearance, primates
Summary of Study: Results provide estimates of SARS-CoV-2 viral kinetic parameters in an experimental model of mild infection and they provide means to assess the efficacy of future antiviral treatments.
References: PMID: 33730053 / doi: 10.1371/journal.pcbi.1008785
Contact Info: Antonio Goncalves: [email protected]
URL: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008785
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, marmosets
Year Published: 2021
Study Type/Review:
NPRC/Institute: Southwest NPRC
Keywords: SARS-CoV-2, young and old animals, Acute respiratory distress, primates
Summary of Study: Acute respiratory distress in macaques and baboons recapitulates the progression of COVID-19 in humans, making them suitable as models to test vaccines and therapies.
References: PMID: 33340034/doi: 10.1038/s41564-020-00841-4
Contact Info: Deepak Kaushal: [email protected]
URL: https://www.nature.com/articles/s41564-020-00841-4
NHP Species: rhesus macaques, marmosets
Year Published: 2021
Study Type/Review:
NPRC/Institute: Southwest NPRC
Keywords: SARS-CoV-2, young and old animals, Acute respiratory distress, primates
Summary of Study: Acute respiratory distress in macaques and baboons recapitulates the progression of COVID-19 in humans, making them suitable as models to test vaccines and therapies.
References: PMID: 33340034/doi: 10.1038/s41564-020-00841-4
Contact Info: Deepak Kaushal: [email protected]
URL: https://www.nature.com/articles/s41564-020-00841-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Tulane National primate Research Center; Tulane School of Medicine; Duke University Medical Center
Keywords: SARS-CoV-2, anti-SARS-CoV-2 monoclonal antibodies, pharmacokinetics, immune response, primates
Summary of Study: A combination of two high-affinity anti-SARS-CoV-2 monoclonal antibodies (mAbs; C144-LS and C135-LS) effectively blocks development of COVID-19 in the rhesus disease model and accelerates the prospect of clinical studies with this effective antibody combination.
References: PMID: 34869063 / doi: 10.3389/fcimb.2021.753444
Contact Info: Chad Roy: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637877/
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Tulane National primate Research Center; Tulane School of Medicine; Duke University Medical Center
Keywords: SARS-CoV-2, anti-SARS-CoV-2 monoclonal antibodies, pharmacokinetics, immune response, primates
Summary of Study: A combination of two high-affinity anti-SARS-CoV-2 monoclonal antibodies (mAbs; C144-LS and C135-LS) effectively blocks development of COVID-19 in the rhesus disease model and accelerates the prospect of clinical studies with this effective antibody combination.
References: PMID: 34869063 / doi: 10.3389/fcimb.2021.753444
Contact Info: Chad Roy: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637877/
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; CureVac AG; Tufts University Cummings School of Veterinary Medicine; University of North Carolina at Chapel Hill; Beth Israel Deaconess Medical Center; Bioqual; Washington University School of Medicine; Ragon Institute of MGH, MIT and Harvard
Keywords: SARS-CoV-2, mRNA vaccine, immunogenicity, protective efficacy, primates
Summary of Study: Optimization of non-coding regions can greatly improve the immunogenicity and protective efficacy of a non-modified mRNA SARS-CoV-2 vaccine in nonhuman primates.
References: PMID: 34794169 / doi: 10.1038/s41586-021-04231-6
Contact Info: Dan Barouch: [email protected]; Susanne Rauch: [email protected]
URL: https://www.nature.com/articles/s41586-021-04231-6
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; CureVac AG; Tufts University Cummings School of Veterinary Medicine; University of North Carolina at Chapel Hill; Beth Israel Deaconess Medical Center; Bioqual; Washington University School of Medicine; Ragon Institute of MGH, MIT and Harvard
Keywords: SARS-CoV-2, mRNA vaccine, immunogenicity, protective efficacy, primates
Summary of Study: Optimization of non-coding regions can greatly improve the immunogenicity and protective efficacy of a non-modified mRNA SARS-CoV-2 vaccine in nonhuman primates.
References: PMID: 34794169 / doi: 10.1038/s41586-021-04231-6
Contact Info: Dan Barouch: [email protected]; Susanne Rauch: [email protected]
URL: https://www.nature.com/articles/s41586-021-04231-6
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: National Institutes of Biomedical Innovation, Health and Nutrition, Tsukuba, Japan; Osaka University; Gunma University; The University of Tokyo; University of Wisconsin-Madison; Mie University Graduate School of Medicine
Keywords: SARS-CoV-2, pathogenicity, old animals, pathology, immune response, primates
Summary of Study: The COVID-19 cynomolgus monkey model reflects the pathophysiology of humans and would be useful for elucidating the pathophysiology and developing therapeutic agents and vaccines.
References: PMID: 34625475 / doi: 10.1073/pnas.2104847118
Contact Info: Yasuhiro Yasutomi: [email protected]
URL: https://www.pnas.org/content/118/43/e2104847118.long
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: National Institutes of Biomedical Innovation, Health and Nutrition, Tsukuba, Japan; Osaka University; Gunma University; The University of Tokyo; University of Wisconsin-Madison; Mie University Graduate School of Medicine
Keywords: SARS-CoV-2, pathogenicity, old animals, pathology, immune response, primates
Summary of Study: The COVID-19 cynomolgus monkey model reflects the pathophysiology of humans and would be useful for elucidating the pathophysiology and developing therapeutic agents and vaccines.
References: PMID: 34625475 / doi: 10.1073/pnas.2104847118
Contact Info: Yasuhiro Yasutomi: [email protected]
URL: https://www.pnas.org/content/118/43/e2104847118.long
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Janssen Vaccines & Prevention; Tufts University Cummings School of Veterinary Medicine; Bioqual; Ragon Institute of MGH, MIT, and Harvard.
Keywords: SARS-CoV-2, adenovirus vectored COVID-19 vaccine, virus transduction, primates
Summary of Study: A single immunization with relatively low dose of Ad26.COV2.S effectively protected against SARS-CV-2 challenge in rhesus macaques, although a higher vaccine dose may be required for protection in the upper respiratory tract.
References: PMID: 34133941 / doi: 10.1016/j.cell.2021.05.040
Contact Info: Dan Barouch: [email protected]
URL: https://www.cell.com/cell/fulltext/S0092-8674(21)00693-0?_returnURL=https%3A//l…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Janssen Vaccines & Prevention; Tufts University Cummings School of Veterinary Medicine; Bioqual; Ragon Institute of MGH, MIT, and Harvard.
Keywords: SARS-CoV-2, adenovirus vectored COVID-19 vaccine, virus transduction, primates
Summary of Study: A single immunization with relatively low dose of Ad26.COV2.S effectively protected against SARS-CV-2 challenge in rhesus macaques, although a higher vaccine dose may be required for protection in the upper respiratory tract.
References: PMID: 34133941 / doi: 10.1016/j.cell.2021.05.040
Contact Info: Dan Barouch: [email protected]
URL: https://www.cell.com/cell/fulltext/S0092-8674(21)00693-0?_returnURL=https%3A//l…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences; Shenzhen Third People's Hospital; Guangzhou Medical University; UT Southwestern Medical Center; and others
Keywords: SARS-CoV-2, fusion protein vaccine, immune response, rodents and primates
Summary of Study: the pan-epitope modified human I-R-F (I-P-R-F) vaccine provides rapid and complete protection throughout the upper and lower respiratory tracts against a high-dose SARS-C0V-2 challenge in rhesus macaques.
References: PMID: 34267349 / doi: 10.1038/s41422-021-00531-8
Contact Info: Yang-Xin Fu: [email protected]
URL: https://www.nature.com/articles/s41422-021-00531-8
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences; Shenzhen Third People's Hospital; Guangzhou Medical University; UT Southwestern Medical Center; and others
Keywords: SARS-CoV-2, fusion protein vaccine, immune response, rodents and primates
Summary of Study: the pan-epitope modified human I-R-F (I-P-R-F) vaccine provides rapid and complete protection throughout the upper and lower respiratory tracts against a high-dose SARS-C0V-2 challenge in rhesus macaques.
References: PMID: 34267349 / doi: 10.1038/s41422-021-00531-8
Contact Info: Yang-Xin Fu: [email protected]
URL: https://www.nature.com/articles/s41422-021-00531-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Milad Daro Noor Pharmaceutical (MDNP) Co., Iran; Stem Cell Technology Research Center (STRC); Imam Hussein University
Keywords: SARS-CoV-2, inactivated vaccine candidate, immunization, immune response, mice, guinea pigs, rabbits, primates
Summary of Study: FAKHRAVAC, a purified inactivated SARS-CoV-2 virus vaccine candidate induced neutralizing antibodies in Balb/c mice, guinea pigs, rabbits, and rhesus macaques.
References: PMID: 34835202 / doi: 10.3390/vaccines9111271
Contact Info: Ahmad Karimi Rahjerdi: [email protected] or [email protected]
URL: https://www.mdpi.com/2076-393X/9/11/1271
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Milad Daro Noor Pharmaceutical (MDNP) Co., Iran; Stem Cell Technology Research Center (STRC); Imam Hussein University
Keywords: SARS-CoV-2, inactivated vaccine candidate, immunization, immune response, mice, guinea pigs, rabbits, primates
Summary of Study: FAKHRAVAC, a purified inactivated SARS-CoV-2 virus vaccine candidate induced neutralizing antibodies in Balb/c mice, guinea pigs, rabbits, and rhesus macaques.
References: PMID: 34835202 / doi: 10.3390/vaccines9111271
Contact Info: Ahmad Karimi Rahjerdi: [email protected] or [email protected]
URL: https://www.mdpi.com/2076-393X/9/11/1271
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Eli Lilly and Co., AbCellera Biologics, UNC - Chapel Hill, University of Texas Medical Branch, and others.
Keywords: SARS-CoV-2, monoclonal antibodies, immune response, primates
Summary of Study: LY-CoV555 (aka bamlanivimab), a potent anti-spike neutralizing antibody from a hospitalized, convalescent patient with COVID-19 was followed in a pharmacokinetic study in cynomolgus monkeys and in a challenge model in rhesus macaques, where it showed impressive results. Currently in clinical testing.
References: PMID: 33820835 / doi: 10.1126/scitranslmed.abf1906
Contact Info: Bryan Jones: [email protected]; Ester Falconer: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abf1906?url_ver=Z39.88-2003&rf…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Eli Lilly and Co., AbCellera Biologics, UNC - Chapel Hill, University of Texas Medical Branch, and others.
Keywords: SARS-CoV-2, monoclonal antibodies, immune response, primates
Summary of Study: LY-CoV555 (aka bamlanivimab), a potent anti-spike neutralizing antibody from a hospitalized, convalescent patient with COVID-19 was followed in a pharmacokinetic study in cynomolgus monkeys and in a challenge model in rhesus macaques, where it showed impressive results. Currently in clinical testing.
References: PMID: 33820835 / doi: 10.1126/scitranslmed.abf1906
Contact Info: Bryan Jones: [email protected]; Ester Falconer: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abf1906?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Washington Univ, SW National Primate Research Center, Texas Biomedical Research Institute
Keywords: SARS-CoV-2, transcriptional signatures, juvenile and old animals, lungs, primates
Summary of Study: Transcriptional profiles of lungs from juvenile and old macaques infected with SARS-CoV-2 were interrogated, providing fundamentally new information on the host response in young and old macaques. This model provides relevant insights necessary for further vaccine and therapeutic development for COVID-19.
References: PMID: 33674719 / doi: 10.1038/s42003-021-01829-4
Contact Info: Makedonka Mitreva: [email protected]; Deepak Kaushal: [email protected]
URL: https://www.nature.com/articles/s42003-021-01829-4
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Washington Univ, SW National Primate Research Center, Texas Biomedical Research Institute
Keywords: SARS-CoV-2, transcriptional signatures, juvenile and old animals, lungs, primates
Summary of Study: Transcriptional profiles of lungs from juvenile and old macaques infected with SARS-CoV-2 were interrogated, providing fundamentally new information on the host response in young and old macaques. This model provides relevant insights necessary for further vaccine and therapeutic development for COVID-19.
References: PMID: 33674719 / doi: 10.1038/s42003-021-01829-4
Contact Info: Makedonka Mitreva: [email protected]; Deepak Kaushal: [email protected]
URL: https://www.nature.com/articles/s42003-021-01829-4
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Hebei Agricultural University; Military Veterinary Research Institute
Keywords: SARS-CoV-2, aerosol particles, virus transduction, primates
Summary of Study: Most SARS-CoV-2 aerosol particles exhaled by the cynomolgus monkeys in this study were smaller (<4.7 um), suggesting that aerosols might be a route for SARS-CoV-2 transmission.
References: PMID: 34152969 / doi: 10.3201/eid2707.203948
Contact Info: Yuwei Gao: [email protected]
URL: https://wwwnc.cdc.gov/eid/article/27/7/20-3948_article
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Hebei Agricultural University; Military Veterinary Research Institute
Keywords: SARS-CoV-2, aerosol particles, virus transduction, primates
Summary of Study: Most SARS-CoV-2 aerosol particles exhaled by the cynomolgus monkeys in this study were smaller (<4.7 um), suggesting that aerosols might be a route for SARS-CoV-2 transmission.
References: PMID: 34152969 / doi: 10.3201/eid2707.203948
Contact Info: Yuwei Gao: [email protected]
URL: https://wwwnc.cdc.gov/eid/article/27/7/20-3948_article
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Nankai University, Chinese Academy of Sciences, and others
Keywords: SARS-CoV-2, monoclonal antibodies, structure analysis, immune response, primates
Summary of Study: The engineered antibody P4A1 (originally identified from COVID-19 convalescent patients) exhibits an optimized pharmacokinetic and safety profile, and results in complete viral clearance in a rhesus monkey model of COVID-19 following a single injection.
References: PMID: 33976198 / doi: 10.1038/s41467-021-22926-2
Contact Info: Yu Guo: [email protected]; Hongkai Zhang: [email protected]
URL: https://www.nature.com/articles/s41467-021-22926-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Nankai University, Chinese Academy of Sciences, and others
Keywords: SARS-CoV-2, monoclonal antibodies, structure analysis, immune response, primates
Summary of Study: The engineered antibody P4A1 (originally identified from COVID-19 convalescent patients) exhibits an optimized pharmacokinetic and safety profile, and results in complete viral clearance in a rhesus monkey model of COVID-19 following a single injection.
References: PMID: 33976198 / doi: 10.1038/s41467-021-22926-2
Contact Info: Yu Guo: [email protected]; Hongkai Zhang: [email protected]
URL: https://www.nature.com/articles/s41467-021-22926-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, neurotropism, central neural system, virus transduction, primates
Summary of Study: The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys.
References: PMID: 33895780 / doi: 10.1038/s41392-021-00591-7
Contact Info: Xiaozhong Peng: [email protected]; Shuaiyao Lu: [email protected]; Hongqi Liu: [email protected]
URL: https://www.nature.com/articles/s41392-021-00591-7
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, neurotropism, central neural system, virus transduction, primates
Summary of Study: The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys.
References: PMID: 33895780 / doi: 10.1038/s41392-021-00591-7
Contact Info: Xiaozhong Peng: [email protected]; Shuaiyao Lu: [email protected]; Hongqi Liu: [email protected]
URL: https://www.nature.com/articles/s41392-021-00591-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, resources, pathology, primates
Summary of Study: Because the SARS-CoV-2 pandemic has significantly increased the demand for rhesus macaques biomedical researchers will need to consider alternative NHP models for COVID-19 research and for other biomedical research studies. The authors suggest alternatives.
References: PMID: 33785923 / doi: 10.1038/s41684-021-00755-6
Contact Info: Michael Chang: chang,[email protected]
URL: https://www.nature.com/articles/s41684-021-00755-6
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, resources, pathology, primates
Summary of Study: Because the SARS-CoV-2 pandemic has significantly increased the demand for rhesus macaques biomedical researchers will need to consider alternative NHP models for COVID-19 research and for other biomedical research studies. The authors suggest alternatives.
References: PMID: 33785923 / doi: 10.1038/s41684-021-00755-6
Contact Info: Michael Chang: chang,[email protected]
URL: https://www.nature.com/articles/s41684-021-00755-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, pigtail macaques, african green monkeys, squirrel monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIAID
Keywords: SARS-CoV-2, pulmonary histopathologic characteristics, immunohistochemistry, species comparison, primates
Summary of Study: Histopathology does not appear to be a superior readout for interpretation of vaccine and therapeutic evaluations in the NHPs studied. The recommendation of which NHP is a superior model should be based on virology data as well as further work on genetic factors that contribute to significant disease.
References: PMID: 34963391 / doi: 10.1177/03009858211067468
Contact Info: Chad Clancy: [email protected]
URL: https://journals.sagepub.com/doi/10.1177/03009858211067468?url_ver=Z39.88-2003&…
NHP Species: rhesus macaques, pigtail macaques, african green monkeys, squirrel monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIAID
Keywords: SARS-CoV-2, pulmonary histopathologic characteristics, immunohistochemistry, species comparison, primates
Summary of Study: Histopathology does not appear to be a superior readout for interpretation of vaccine and therapeutic evaluations in the NHPs studied. The recommendation of which NHP is a superior model should be based on virology data as well as further work on genetic factors that contribute to significant disease.
References: PMID: 34963391 / doi: 10.1177/03009858211067468
Contact Info: Chad Clancy: [email protected]
URL: https://journals.sagepub.com/doi/10.1177/03009858211067468?url_ver=Z39.88-2003&…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: National Health Commission of the People's Republic of China; Chinese Academy of Sciences; Nanjing Medical University; Beijing Institute of Microbiology and Epidemiology; Jiangsu Rec-biotechnology Col Ltd.
Keywords: SARS-CoV-2, neutralizing antibodies, immunization, spike protein, immunogenicity, rabbits, primates
Summary of Study: The immunogenic data derived from immunization with a combination of SARS-CoV-2 RBD and NTD demonstrate the feasibility of eliciting robust targeted immune profiles by using antibody-guided vaccine design.
References: PMID: 34676098 / doi: 10.1093/nsr/nwab053
Contact Info: Xiangxi Wang: [email protected]; Cheng-Feng Qin: [email protected]; Feng-Cai Zhu: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083607/
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: National Health Commission of the People's Republic of China; Chinese Academy of Sciences; Nanjing Medical University; Beijing Institute of Microbiology and Epidemiology; Jiangsu Rec-biotechnology Col Ltd.
Keywords: SARS-CoV-2, neutralizing antibodies, immunization, spike protein, immunogenicity, rabbits, primates
Summary of Study: The immunogenic data derived from immunization with a combination of SARS-CoV-2 RBD and NTD demonstrate the feasibility of eliciting robust targeted immune profiles by using antibody-guided vaccine design.
References: PMID: 34676098 / doi: 10.1093/nsr/nwab053
Contact Info: Xiangxi Wang: [email protected]; Cheng-Feng Qin: [email protected]; Feng-Cai Zhu: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083607/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Duke University; UNC Chapel Hill; 3M Corporate Research Materials Laboratory; Infectious Disease Research Institute; California National Primate Research Center; and others
Keywords: SARS-CoV-2, mRNA vaccine, infants, immune response, primates
Summary of Study: Infant rhesus macaques were vaccinated with an mRNA-based SARS-CoV-2 vaccine, similar to the Moderna vaccine, or an S protein plus TLR7/8 agonist-based vaccine. Both vaccines induced profound induction of neutralizing antibody titers, memory B cells responses, and SARS-CV-2 specific CD4+ T cell responses that were long-lasting, all while limiting vaccine related toxicity.
References: PMID: 34131024 / doi: 10.1126/sciimmunol.abj3684
Contact Info: Kristina De Paris: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.abj3684?url_ver=Z39.88-2003&rfr_…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Duke University; UNC Chapel Hill; 3M Corporate Research Materials Laboratory; Infectious Disease Research Institute; California National Primate Research Center; and others
Keywords: SARS-CoV-2, mRNA vaccine, infants, immune response, primates
Summary of Study: Infant rhesus macaques were vaccinated with an mRNA-based SARS-CoV-2 vaccine, similar to the Moderna vaccine, or an S protein plus TLR7/8 agonist-based vaccine. Both vaccines induced profound induction of neutralizing antibody titers, memory B cells responses, and SARS-CV-2 specific CD4+ T cell responses that were long-lasting, all while limiting vaccine related toxicity.
References: PMID: 34131024 / doi: 10.1126/sciimmunol.abj3684
Contact Info: Kristina De Paris: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.abj3684?url_ver=Z39.88-2003&rfr_…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Center for Disease Control and Prevention; Chinese Academy of Medical Sciences & Peking Union Medical College; Chinese Academy of Sciences
Keywords: SARS-CoV-2, mRNA vaccine, nanoparticles, immune response, pathology, mice and primates
Summary of Study: Using both mouse and rhesus macaque SARS-CoV-2 challenge models, this study demonstrates strong immunogenicity, protective ability and high safety profiles of SW0123 (an LPP-based mRA vaccine), and supports this promising candidate for future clinical evaluation.
References: PMID: 34059617 / doi: 10.1038/s41392-021-00634-z
Contact Info: Wenjie Tan: [email protected]; Xiaozhong Peng: [email protected]
URL: https://www.nature.com/articles/s41392-021-00634-z
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Center for Disease Control and Prevention; Chinese Academy of Medical Sciences & Peking Union Medical College; Chinese Academy of Sciences
Keywords: SARS-CoV-2, mRNA vaccine, nanoparticles, immune response, pathology, mice and primates
Summary of Study: Using both mouse and rhesus macaque SARS-CoV-2 challenge models, this study demonstrates strong immunogenicity, protective ability and high safety profiles of SW0123 (an LPP-based mRA vaccine), and supports this promising candidate for future clinical evaluation.
References: PMID: 34059617 / doi: 10.1038/s41392-021-00634-z
Contact Info: Wenjie Tan: [email protected]; Xiaozhong Peng: [email protected]
URL: https://www.nature.com/articles/s41392-021-00634-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: UC Davis, National Institutes of Health (Pakistan), California National Primate Research Center, New York State Department of Health
Keywords: SARS-CoV-2, multiplex test, immune response, primates
Summary of Study: The authors report the development and validation of a multiplex bead assay to simultaneously and specifically detect antibodies to the SARS-CoV-2, SARS-CoV, MERS-CoV and common human coronavirus strains (229E, NL63, OC43, HKU1). Multiplex serological assays enabled the investigation of the dynamics of immune responses in COVID-19 patients.
References: PMID: 34242356 / doi: 10.1371/journal.pone.0254367
Contact Info: Imran Khan: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0254367
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: UC Davis, National Institutes of Health (Pakistan), California National Primate Research Center, New York State Department of Health
Keywords: SARS-CoV-2, multiplex test, immune response, primates
Summary of Study: The authors report the development and validation of a multiplex bead assay to simultaneously and specifically detect antibodies to the SARS-CoV-2, SARS-CoV, MERS-CoV and common human coronavirus strains (229E, NL63, OC43, HKU1). Multiplex serological assays enabled the investigation of the dynamics of immune responses in COVID-19 patients.
References: PMID: 34242356 / doi: 10.1371/journal.pone.0254367
Contact Info: Imran Khan: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0254367