Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Univ. of Pennsylvania Perelman School of Medicine
Keywords: SARS-CoV-2, D614G Spike Mutation, Vaccinated and immune sera, neutralization, primates
Summary of Study: Vaccinated NHPs using the nucleoside-modified mRNA-LNP vaccine platform encoding four differentSARS-CoV-2 spike immunogens generate antibody responses that not only recognize the G614 mutation that has taken over the pandemic, but also have stronger titers of neutralization to this virus variant.
References: PMID: 33306985/doi: 10.1016/j.chom.2020.11.012
Contact Info: Drew Weissman (no contact information)
URL: https://www.sciencedirect.com/science/article/pii/S193131282030634X?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Univ. of Pennsylvania Perelman School of Medicine
Keywords: SARS-CoV-2, D614G Spike Mutation, Vaccinated and immune sera, neutralization, primates
Summary of Study: Vaccinated NHPs using the nucleoside-modified mRNA-LNP vaccine platform encoding four differentSARS-CoV-2 spike immunogens generate antibody responses that not only recognize the G614 mutation that has taken over the pandemic, but also have stronger titers of neutralization to this virus variant.
References: PMID: 33306985/doi: 10.1016/j.chom.2020.11.012
Contact Info: Drew Weissman (no contact information)
URL: https://www.sciencedirect.com/science/article/pii/S193131282030634X?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, inactivated vaccines, antibody-dependent enhancement, immunopathology, primates
Summary of Study: Results show that in the absence of cellular immunity, passive infusion of subneutralizing or nonneutralizing anti-SARS-CoV-2 antibodies could still provide some level of protection against infection upon challenge, and no low-level antibody-enhanced infection was observed.
References: PMID: 34736354 / doi: 10.1080/22221751.2021.2002670
Contact Info: Qihan Li: liqihan@imbcams.com.cn; Longding Liu: longdingliu@imbcams.com.cn; Cunbao Liu: cunbao_liu@163.com
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2002670
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, inactivated vaccines, antibody-dependent enhancement, immunopathology, primates
Summary of Study: Results show that in the absence of cellular immunity, passive infusion of subneutralizing or nonneutralizing anti-SARS-CoV-2 antibodies could still provide some level of protection against infection upon challenge, and no low-level antibody-enhanced infection was observed.
References: PMID: 34736354 / doi: 10.1080/22221751.2021.2002670
Contact Info: Qihan Li: liqihan@imbcams.com.cn; Longding Liu: longdingliu@imbcams.com.cn; Cunbao Liu: cunbao_liu@163.com
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2002670
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Beijing DanXu Biopharmaceuticals
Keywords: SARS-CoV-2, monoclonal antibody, ELISA assay, pharmacokinetic, primates
Summary of Study: In cynomolgus monkeys, BD-604 (a fully human monoclonal antibody) possesses pharmacokinetic properties similar to natural IgGs.
References: PMID: 34215019 / doi: 10.1002/dta.3122
Contact Info: Xu Zhang: janet_xu_zhang@singlomics.com
URL: https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/dta.3122
NHP Species:
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Beijing DanXu Biopharmaceuticals
Keywords: SARS-CoV-2, monoclonal antibody, ELISA assay, pharmacokinetic, primates
Summary of Study: In cynomolgus monkeys, BD-604 (a fully human monoclonal antibody) possesses pharmacokinetic properties similar to natural IgGs.
References: PMID: 34215019 / doi: 10.1002/dta.3122
Contact Info: Xu Zhang: janet_xu_zhang@singlomics.com
URL: https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/dta.3122
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences
Keywords: SARS-CoV-2, combined intratracheal and intranasal inoculation, primates
Summary of Study: The severity of respiratory tract infection enhanced air transmission and induced wide and severe SARS-CoV-2 infection in the lungs, suggesting the occurrence of more severe infectiousness and lung injury in SARS-CoV-2 patients with nasal infection.
References: PMID: 33587263 / doi: 10.1007/s11427-020-1877-4
Contact Info: Yong-Tang Zheng: zhengyt@mail.kiz.ac.cn
URL: https://link.springer.com/article/10.1007%2Fs11427-020-1877-4
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences
Keywords: SARS-CoV-2, combined intratracheal and intranasal inoculation, primates
Summary of Study: The severity of respiratory tract infection enhanced air transmission and induced wide and severe SARS-CoV-2 infection in the lungs, suggesting the occurrence of more severe infectiousness and lung injury in SARS-CoV-2 patients with nasal infection.
References: PMID: 33587263 / doi: 10.1007/s11427-020-1877-4
Contact Info: Yong-Tang Zheng: zhengyt@mail.kiz.ac.cn
URL: https://link.springer.com/article/10.1007%2Fs11427-020-1877-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Florida State University; University of Texas Medical Branch; Perelman School of Medicine; Duke University Medical Center; Johns Hopkins School of Medicine
Keywords: SARS-CoV-2, respiratory viral challenge, immune response, pathology, primates
Summary of Study: Data demonstrate that SARS-CoV-2 infection of pigtail macaques recapitulates important features of COVID-19 and reveals new immune and viral dynamics and thus may serve as a useful animal model for studying pathogenesis and testing vaccines and therapeutics.
References: PMID: 34929014 / doi: 10.1371/journal.ppat.1010162
Contact Info: Nicholas Maness: nmaness@tulane.edu
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010162
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Florida State University; University of Texas Medical Branch; Perelman School of Medicine; Duke University Medical Center; Johns Hopkins School of Medicine
Keywords: SARS-CoV-2, respiratory viral challenge, immune response, pathology, primates
Summary of Study: Data demonstrate that SARS-CoV-2 infection of pigtail macaques recapitulates important features of COVID-19 and reveals new immune and viral dynamics and thus may serve as a useful animal model for studying pathogenesis and testing vaccines and therapeutics.
References: PMID: 34929014 / doi: 10.1371/journal.ppat.1010162
Contact Info: Nicholas Maness: nmaness@tulane.edu
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010162
Coronavirus Investigated: SARS-CoV-2
NHP Species: tamarins, marmosets, howler monkeys, titi monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Faculdade de Medicina de Sao Jose do Rio Preto, Brazil; Fundacao de Medicina Tropical Doutor Heitor Vieria Dourado, Brazil; Universidade do Estado do Amazonas, Brazil; Universidade Federal do Amazonas, Brazil; Universidade de Sao Paulo, Brazil; Hospital Israelita Albert Einstein; Instituto Butanta; Departamento de Vigilancia Epidemiologica de Sao Jose do Rio Preto; New Mexico State University; The University of Texas Medical Branch, Galveston; Instituto Leonidas e Maria Deane, Brazil
Keywords: SARS-CoV-2, wild animals, molecular and serological tests, primates
Summary of Study: Although no evidence of SARS-CoV-2 infection was detected, continued surveillance of NHPs in this region is warranted and may identify geographic areas or particular NHP species prone to spillover.
References: PMID: 34696363 / doi: 10.3390/v13101933
Contact Info: Marcus Vinicius Guimaraes de Lacerda: marcuslacerda.br@gmail.com; Mauricio Lacerda Nogueira: mnogueira@famerp.br
URL: https://www.mdpi.com/1999-4915/13/10/1933
NHP Species: tamarins, marmosets, howler monkeys, titi monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Faculdade de Medicina de Sao Jose do Rio Preto, Brazil; Fundacao de Medicina Tropical Doutor Heitor Vieria Dourado, Brazil; Universidade do Estado do Amazonas, Brazil; Universidade Federal do Amazonas, Brazil; Universidade de Sao Paulo, Brazil; Hospital Israelita Albert Einstein; Instituto Butanta; Departamento de Vigilancia Epidemiologica de Sao Jose do Rio Preto; New Mexico State University; The University of Texas Medical Branch, Galveston; Instituto Leonidas e Maria Deane, Brazil
Keywords: SARS-CoV-2, wild animals, molecular and serological tests, primates
Summary of Study: Although no evidence of SARS-CoV-2 infection was detected, continued surveillance of NHPs in this region is warranted and may identify geographic areas or particular NHP species prone to spillover.
References: PMID: 34696363 / doi: 10.3390/v13101933
Contact Info: Marcus Vinicius Guimaraes de Lacerda: marcuslacerda.br@gmail.com; Mauricio Lacerda Nogueira: mnogueira@famerp.br
URL: https://www.mdpi.com/1999-4915/13/10/1933
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center, Tulane University School of Medicine, Tulane University, Brigham and Women's Hospital/Harvard Medical School, LSU Health Science Center, Julius-Maximilians-Universitat Wurzburg, and more
Keywords: SARS-CoV-2, pulmonary vascular endotheliosis, perivascular inflammation, rodents and primates
Summary of Study: SARS-CoV-2 causes endotheliitis via both infection and infection-mediated immune activation, which may contribute to the pathogenesis of severe COVID-19 disease.
References: PMID: 34335981 / doi: 10.7150/thno.61810
Contact Info: Jay Kolls: jkolls1@tulane.edu; Fengming Liu: fliu6@tulane.edu; Jay Rappaport: jrappaport@tulane.edu
URL: https://www.thno.org/v11p8076.htm
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center, Tulane University School of Medicine, Tulane University, Brigham and Women's Hospital/Harvard Medical School, LSU Health Science Center, Julius-Maximilians-Universitat Wurzburg, and more
Keywords: SARS-CoV-2, pulmonary vascular endotheliosis, perivascular inflammation, rodents and primates
Summary of Study: SARS-CoV-2 causes endotheliitis via both infection and infection-mediated immune activation, which may contribute to the pathogenesis of severe COVID-19 disease.
References: PMID: 34335981 / doi: 10.7150/thno.61810
Contact Info: Jay Kolls: jkolls1@tulane.edu; Fengming Liu: fliu6@tulane.edu; Jay Rappaport: jrappaport@tulane.edu
URL: https://www.thno.org/v11p8076.htm
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences; Shenzhen Kangtai Biotechnology Co., Ltd.; Academy of Military Medical Sciences; Zhenzhou University; National Institutes for Food and Drug Control; Henan Normal University
Keywords: SARS-CoV-2, chimeric spike protein, humoral immune response, pathology, mice, primates
Summary of Study: The strategy of chimerica expression SARS-CoV-2 S RBD in SARS-CoV represents a new design for other vaccine platforms.
References: PMID: 34759261 / doi: 10.1038/s41392-021-00797-9
Contact Info: Shuguang Duo: duoshuguang@ioz.ac.cn
URL: https://www.nature.com/articles/s41392-021-00797-9
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences; Shenzhen Kangtai Biotechnology Co., Ltd.; Academy of Military Medical Sciences; Zhenzhou University; National Institutes for Food and Drug Control; Henan Normal University
Keywords: SARS-CoV-2, chimeric spike protein, humoral immune response, pathology, mice, primates
Summary of Study: The strategy of chimerica expression SARS-CoV-2 S RBD in SARS-CoV represents a new design for other vaccine platforms.
References: PMID: 34759261 / doi: 10.1038/s41392-021-00797-9
Contact Info: Shuguang Duo: duoshuguang@ioz.ac.cn
URL: https://www.nature.com/articles/s41392-021-00797-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Celltech Pharmed Co.; Iran University of Medical Sciences; University of Iran; Tarbiat Modares University; Royan Institute for Stem Cell Biology and Technology; and others
Keywords: SARS-CoV-2, mRNA-vaccine, lipid nanoparticle, spike protein, immune response, primates
Summary of Study: A novel mRNA-LNP vaccine against SARS-CoV-2 was developed and preclinically evaluated, revealing that it was efficient enough to induce hgih level production of neutralizing antibodies against SARS-CoV-2 in mice and rhesus macaque monkeys.
References: PMID: 34579244 / doi: 10.3390/vaccines9091007
Contact Info: Alireza Sohi: nanosohi@strc.ac.ir; Jafar Kiani: kiani.ja@iums.ac.ir; Ehsan Arefian: arefian@ut.ac.ir; Arezou Khosrojerdi: arezou.khosrojerdi@modares.ac.ir; Mohammad Zim: mk.zim73@ut.ac.ir
URL: https://www.mdpi.com/2076-393X/9/9/1007
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Celltech Pharmed Co.; Iran University of Medical Sciences; University of Iran; Tarbiat Modares University; Royan Institute for Stem Cell Biology and Technology; and others
Keywords: SARS-CoV-2, mRNA-vaccine, lipid nanoparticle, spike protein, immune response, primates
Summary of Study: A novel mRNA-LNP vaccine against SARS-CoV-2 was developed and preclinically evaluated, revealing that it was efficient enough to induce hgih level production of neutralizing antibodies against SARS-CoV-2 in mice and rhesus macaque monkeys.
References: PMID: 34579244 / doi: 10.3390/vaccines9091007
Contact Info: Alireza Sohi: nanosohi@strc.ac.ir; Jafar Kiani: kiani.ja@iums.ac.ir; Ehsan Arefian: arefian@ut.ac.ir; Arezou Khosrojerdi: arezou.khosrojerdi@modares.ac.ir; Mohammad Zim: mk.zim73@ut.ac.ir
URL: https://www.mdpi.com/2076-393X/9/9/1007
Coronavirus Investigated: SARS-CoV-2
NHP Species: lemurs, lorises
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Calgary; Institut de Biologia Evolutiva, Universitat Pompeu Fabra; North Carolina Central University, Duke University and others
Keywords: SARS-CoV-2, ACE2 gene and protein sequences, several species, primates
Summary of Study: Study suggests that lemurs of the families Indriidae, Daubentonlidae, and Lemuridae are likely to be particularly vulnerable to SARS-CoV-2 infection.
References: PMID: 33792947 / doi: 10.1002/ajp.23255
Contact Info: James Higham: jhigham@nyu.edu
URL: https://onlinelibrary.wiley.com/doi/10.1002/ajp.23255
NHP Species: lemurs, lorises
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Calgary; Institut de Biologia Evolutiva, Universitat Pompeu Fabra; North Carolina Central University, Duke University and others
Keywords: SARS-CoV-2, ACE2 gene and protein sequences, several species, primates
Summary of Study: Study suggests that lemurs of the families Indriidae, Daubentonlidae, and Lemuridae are likely to be particularly vulnerable to SARS-CoV-2 infection.
References: PMID: 33792947 / doi: 10.1002/ajp.23255
Contact Info: James Higham: jhigham@nyu.edu
URL: https://onlinelibrary.wiley.com/doi/10.1002/ajp.23255
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: State Key Laboratory of Veterinary Biotechnologi, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences
Keywords: SARS-CoV-2, virus entry mediated by ACE2, several species
Summary of Study: A natural isoform of the rhesus macaque ACE2 protein with the Y217N mutation was resistant to SARS-CoV-2 infection, highlighting the possible impact of this ACE2 mutation on SARS-CoV-2 studies in rhesus macaques. The authors also demonstrated that the Y217 residue of ACE2 is a critical determinant for the ability of ACE2 to mediate SARS-CoV-2 entry. The results of this study clarify that SARS-CoV-2 can use the ACE2 receptors of multiple animal species and show that tracking the natural reservoirs and intermediate hosts of SARS-CoV-2 is complex.
References: PMID: 33610551 / doi: 10.1016/j.jbc.2021.100435
Contact Info: Yan-Dong Tang: tangyandong2008@163.com
URL: https://www.sciencedirect.com/science/article/pii/S0021925821002088?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: State Key Laboratory of Veterinary Biotechnologi, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences
Keywords: SARS-CoV-2, virus entry mediated by ACE2, several species
Summary of Study: A natural isoform of the rhesus macaque ACE2 protein with the Y217N mutation was resistant to SARS-CoV-2 infection, highlighting the possible impact of this ACE2 mutation on SARS-CoV-2 studies in rhesus macaques. The authors also demonstrated that the Y217 residue of ACE2 is a critical determinant for the ability of ACE2 to mediate SARS-CoV-2 entry. The results of this study clarify that SARS-CoV-2 can use the ACE2 receptors of multiple animal species and show that tracking the natural reservoirs and intermediate hosts of SARS-CoV-2 is complex.
References: PMID: 33610551 / doi: 10.1016/j.jbc.2021.100435
Contact Info: Yan-Dong Tang: tangyandong2008@163.com
URL: https://www.sciencedirect.com/science/article/pii/S0021925821002088?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Russian Academy of Sciences, Sechenov First Moscow State Medical University, Lomonosov Moscow State University
Keywords: SARS-CoV-2, serology, neutralizing antibodies, immunogenicity, inactivated vaccine, primates
Summary of Study: A B-propiolactone-inactivated whole virion vaccine CoviVac was developed and assessed. The vaccine produced stable and robust humoral immune response in mice, Syrian hamsters and common marmosets.
References: PMID: 34427172 / doi: 10.1080/22221751.2021.1971569
Contact Info: Liubov Kozlovskaya: lubov_i_k@mail.ru
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1971569
NHP Species: marmosets
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Russian Academy of Sciences, Sechenov First Moscow State Medical University, Lomonosov Moscow State University
Keywords: SARS-CoV-2, serology, neutralizing antibodies, immunogenicity, inactivated vaccine, primates
Summary of Study: A B-propiolactone-inactivated whole virion vaccine CoviVac was developed and assessed. The vaccine produced stable and robust humoral immune response in mice, Syrian hamsters and common marmosets.
References: PMID: 34427172 / doi: 10.1080/22221751.2021.1971569
Contact Info: Liubov Kozlovskaya: lubov_i_k@mail.ru
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1971569
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, hamadryas baboons, marmosets
Year Published: 2021
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center, Texas Biomedical Research Institute, Regeneron, and others
Keywords: SARS-CoV-2, severe acute respiratory syndrome, young and old animals, primates
Summary of Study: Acute respiratory distress in macaques and baboons recapitulates the progression of COVID-19 in humans, making them suitable as models to test vaccines and therapies.
References: PMID: 33340034 / doi: 10.1038/s41564-020-00841-4
Contact Info: Deepak Kaushal: dkaushal@txbiomed.org, Luis Giavedoni: lgiavedoni@txbiomed.org
URL: https://www.nature.com/articles/s41564-020-00841-4#Sec9
NHP Species: rhesus macaques, hamadryas baboons, marmosets
Year Published: 2021
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center, Texas Biomedical Research Institute, Regeneron, and others
Keywords: SARS-CoV-2, severe acute respiratory syndrome, young and old animals, primates
Summary of Study: Acute respiratory distress in macaques and baboons recapitulates the progression of COVID-19 in humans, making them suitable as models to test vaccines and therapies.
References: PMID: 33340034 / doi: 10.1038/s41564-020-00841-4
Contact Info: Deepak Kaushal: dkaushal@txbiomed.org, Luis Giavedoni: lgiavedoni@txbiomed.org
URL: https://www.nature.com/articles/s41564-020-00841-4#Sec9
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Duke University School of Medicine, UNC Chapel Hill, NIAID, Harvard Medical School, and others
Keywords: SARS-CoV-2, neutralizing antibodies, immune response, primates
Summary of Study: In vitro infection-enhancing RBC and NTD ABs controlled virus in vito and was rarely associated with enhanced lung pathology.
References: PMID: 34242577 / doi: 10.1016/j.cell.2021.06.021
Contact Info: Barton Haynes (Duke University School of Medicine); Kevin Saunders (Duke University School of Medicine)
URL: https://www.sciencedirect.com/science/article/pii/S009286742100756X?via%3Dihub=
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Duke University School of Medicine, UNC Chapel Hill, NIAID, Harvard Medical School, and others
Keywords: SARS-CoV-2, neutralizing antibodies, immune response, primates
Summary of Study: In vitro infection-enhancing RBC and NTD ABs controlled virus in vito and was rarely associated with enhanced lung pathology.
References: PMID: 34242577 / doi: 10.1016/j.cell.2021.06.021
Contact Info: Barton Haynes (Duke University School of Medicine); Kevin Saunders (Duke University School of Medicine)
URL: https://www.sciencedirect.com/science/article/pii/S009286742100756X?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Sabzevar University of Medical Sciences, University of Edinburgh, Nagasaki University
Keywords: SARS-CoV-2, infective dose, several animal species, pathogenesis, primates
Summary of Study: This review focused on comparative infective dose studies for SARS-CoV-2, SARS-CoV-1, and MERS. The review suggests that the infective dose in humans is small, perhaps about 100 particles. Further work is required to understand the relationship between routes of transmission, infective dose, co-infection and outcomes.
References: PMID: 33849679 / doi: 10.1017/S0950268821000790
Contact Info: Sedighe Karimzadeh: sedigekarimsadeh@gmail.com; Raj Bhopal: Raj.Bhopal@ed.ac.uk
URL: https://www.cambridge.org/core/journals/epidemiology-and-infection/article/revi…
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Sabzevar University of Medical Sciences, University of Edinburgh, Nagasaki University
Keywords: SARS-CoV-2, infective dose, several animal species, pathogenesis, primates
Summary of Study: This review focused on comparative infective dose studies for SARS-CoV-2, SARS-CoV-1, and MERS. The review suggests that the infective dose in humans is small, perhaps about 100 particles. Further work is required to understand the relationship between routes of transmission, infective dose, co-infection and outcomes.
References: PMID: 33849679 / doi: 10.1017/S0950268821000790
Contact Info: Sedighe Karimzadeh: sedigekarimsadeh@gmail.com; Raj Bhopal: Raj.Bhopal@ed.ac.uk
URL: https://www.cambridge.org/core/journals/epidemiology-and-infection/article/revi…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; Emory University; Duke University Medical Center; Moderna; BIOQUAL
Keywords: SARS-CoV-2, mRNA-vaccine, immune response, hamsters, primates
Summary of Study: mRNA-1273 vaccine-induced antibody responses are a mechanistic correlate of protection against SARS-CoV-2 infection in NHP.
References: PMID: 34529476 / doi: 10.1126/science.abj0299
Contact Info: Barney Graham: bgraham@nih.gov; Robert Seder: rseder@mail.nih.gov
URL: https://www.science.org/doi/10.1126/science.abj0299?url_ver=Z39.88-2003&rfr_id=…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; Emory University; Duke University Medical Center; Moderna; BIOQUAL
Keywords: SARS-CoV-2, mRNA-vaccine, immune response, hamsters, primates
Summary of Study: mRNA-1273 vaccine-induced antibody responses are a mechanistic correlate of protection against SARS-CoV-2 infection in NHP.
References: PMID: 34529476 / doi: 10.1126/science.abj0299
Contact Info: Barney Graham: bgraham@nih.gov; Robert Seder: rseder@mail.nih.gov
URL: https://www.science.org/doi/10.1126/science.abj0299?url_ver=Z39.88-2003&rfr_id=…
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences, Nanjing University
Keywords: SARS-CoV-2, pathology, primates
Summary of Study: SARS-CoV-2-infected northern pig-tailed macaques could be considered as a critically ill animal model in COVID-19 research.
References: PMID: 33998182 / doi: 10.24272/j.issn.2095-8137.2020.334
Contact Info: Yong-Tang Zheng: zhengyt@mail.kiz.ac.cn
URL: http://www.zoores.ac.cn/article/doi/10.24272/j.issn.2095-8137.2020.334
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences, Nanjing University
Keywords: SARS-CoV-2, pathology, primates
Summary of Study: SARS-CoV-2-infected northern pig-tailed macaques could be considered as a critically ill animal model in COVID-19 research.
References: PMID: 33998182 / doi: 10.24272/j.issn.2095-8137.2020.334
Contact Info: Yong-Tang Zheng: zhengyt@mail.kiz.ac.cn
URL: http://www.zoores.ac.cn/article/doi/10.24272/j.issn.2095-8137.2020.334
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Texas Medical Branch
Keywords: SARS-CoV-2, apoptosis, lung tissues, pathology, primates
Summary of Study: Significant increases in apoptotic signals in postmortem lung sections from COVID-19 patients and lungs of NHPs infected with SARS-CoV-2 on day 21 p.i.
References: PMID: 33922476 / doi: 10.3390/pathogens10050509
Contact Info: Paul Boor: pboor@utmb.edu; Jason Comer: jscomer@utmb.edu; Bin Gong: bigong@utmb.edu
URL: https://www.mdpi.com/2076-0817/10/5/509
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Texas Medical Branch
Keywords: SARS-CoV-2, apoptosis, lung tissues, pathology, primates
Summary of Study: Significant increases in apoptotic signals in postmortem lung sections from COVID-19 patients and lungs of NHPs infected with SARS-CoV-2 on day 21 p.i.
References: PMID: 33922476 / doi: 10.3390/pathogens10050509
Contact Info: Paul Boor: pboor@utmb.edu; Jason Comer: jscomer@utmb.edu; Bin Gong: bigong@utmb.edu
URL: https://www.mdpi.com/2076-0817/10/5/509
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Weill Cornell Medical College
Keywords: SARS-CoV-2, antibody and T cell immunogenicity, testing vaccines in humans and primates, review
Summary of Study: This review article summaries what is known of the antibody and T cell immunogenicity of multiple preventive vaccines in NHPs and humans.
References: PMID: 33608249 / doi: 10.1126/sciadv.abe8065
Contact Info: John Moore: jpm2003@med.cornell.edu
URL: https://advances.sciencemag.org/content/7/12/eabe8065
NHP Species: multiple species
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Weill Cornell Medical College
Keywords: SARS-CoV-2, antibody and T cell immunogenicity, testing vaccines in humans and primates, review
Summary of Study: This review article summaries what is known of the antibody and T cell immunogenicity of multiple preventive vaccines in NHPs and humans.
References: PMID: 33608249 / doi: 10.1126/sciadv.abe8065
Contact Info: John Moore: jpm2003@med.cornell.edu
URL: https://advances.sciencemag.org/content/7/12/eabe8065
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Chinese Academy of Sciences; State Key Laboratory of Pathogen an dBiosecutiry, Academy of Military Medical Sciences, Beijing; Sinocelltech Ltd., National Institutes for Food and Drug Control, Beijing; Institute for Biological Product Control, Beijing
Keywords: SARS-CoV-2, monoclonal antibody, preclinical safety evaluation, cryo-EM structure, mice, primates
Summary of Study: Increasing access to panels of authentic neutralizing monoclonal antibodies will facilitate structure-function studies to unpick the underlying biological processes of virus-host interactions, and provide molecular basis for applying HB27 for potential COVID-19 treatment.
References: PMID: 34676096 / doi: 10.1093/nsr/nwaa297
Contact Info: Cheng-Feng Qin: qincf@bmi.ac.cn; Xiangxi Wang: xiangxi@ibp.ac.cn; Youchun Wang: wangyc@nifdc.org.cn; Zihe Rao: raozh@tsinghua.edu.cn; Liangzhi Xie: liangzhi@yahoo.com
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798916/
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Chinese Academy of Sciences; State Key Laboratory of Pathogen an dBiosecutiry, Academy of Military Medical Sciences, Beijing; Sinocelltech Ltd., National Institutes for Food and Drug Control, Beijing; Institute for Biological Product Control, Beijing
Keywords: SARS-CoV-2, monoclonal antibody, preclinical safety evaluation, cryo-EM structure, mice, primates
Summary of Study: Increasing access to panels of authentic neutralizing monoclonal antibodies will facilitate structure-function studies to unpick the underlying biological processes of virus-host interactions, and provide molecular basis for applying HB27 for potential COVID-19 treatment.
References: PMID: 34676096 / doi: 10.1093/nsr/nwaa297
Contact Info: Cheng-Feng Qin: qincf@bmi.ac.cn; Xiangxi Wang: xiangxi@ibp.ac.cn; Youchun Wang: wangyc@nifdc.org.cn; Zihe Rao: raozh@tsinghua.edu.cn; Liangzhi Xie: liangzhi@yahoo.com
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798916/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: California National Primate Research Center; University of California, Davis; Louisiana State University Health Sciences Center; The Rockefeller University.
Keywords: SARS-CoV-2, neuroinflammation, effector CD4 T cells, inflammation, cerebrospinal fluid, pneumonia, primates
Summary of Study: Neutralizing mABs administered preventatively to high-risk populations may mitigate the adverse inflammatory consequences of SARS-CoV-2 exposure.
References: PMID: 34706272 / doi: 10.1016/j.celrep.2021.109942
Contact Info: Smita Iyer: smiyer@ucdavis.edu
URL: https://www.sciencedirect.com/science/article/pii/S2211124721014157?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: California National Primate Research Center; University of California, Davis; Louisiana State University Health Sciences Center; The Rockefeller University.
Keywords: SARS-CoV-2, neuroinflammation, effector CD4 T cells, inflammation, cerebrospinal fluid, pneumonia, primates
Summary of Study: Neutralizing mABs administered preventatively to high-risk populations may mitigate the adverse inflammatory consequences of SARS-CoV-2 exposure.
References: PMID: 34706272 / doi: 10.1016/j.celrep.2021.109942
Contact Info: Smita Iyer: smiyer@ucdavis.edu
URL: https://www.sciencedirect.com/science/article/pii/S2211124721014157?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Wuhan Institute of Virology, Chinese Academy of Sciences; University of the Chinese Academy of Sciences; Wuhan YZY Biopharma Co., Ltd.
Keywords: SARS-CoV-2, subunit vaccine, immunity, virus load, pathology, primates
Summary of Study: The RBD-homodimer vaccine candidate studied can induce both humoral and cellular response in vivo and prevent SARS-CoV-2 infection in both rodents and non-human primates. Production of this RBD vaccine candidate can be performed in large scale, which will enhance the vaccine supply and warrants future clinical trials.
References: PMID: 34493710 / doi: 10.1038/s41421-021-00320-y
Contact Info: Zhiming Yuan: yzm@wh.iov.cn; Chao Shan: shanchao@wh.iov.cn; Genfu Xiao: xiaogf@wh.iov.cn
URL: https://www.nature.com/articles/s41421-021-00320-y
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Wuhan Institute of Virology, Chinese Academy of Sciences; University of the Chinese Academy of Sciences; Wuhan YZY Biopharma Co., Ltd.
Keywords: SARS-CoV-2, subunit vaccine, immunity, virus load, pathology, primates
Summary of Study: The RBD-homodimer vaccine candidate studied can induce both humoral and cellular response in vivo and prevent SARS-CoV-2 infection in both rodents and non-human primates. Production of this RBD vaccine candidate can be performed in large scale, which will enhance the vaccine supply and warrants future clinical trials.
References: PMID: 34493710 / doi: 10.1038/s41421-021-00320-y
Contact Info: Zhiming Yuan: yzm@wh.iov.cn; Chao Shan: shanchao@wh.iov.cn; Genfu Xiao: xiaogf@wh.iov.cn
URL: https://www.nature.com/articles/s41421-021-00320-y
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Korea Research Institute of Bioscience & Biotechnology, Chonnam National University, Chungbuk National University
Keywords: SARS-CoV-2, virus variants, microevolution, species specific variations, primates
Summary of Study: The genomes of SARS-CoV-2 differ according to individuals and species despite infection of the identical virus in NHPs. These results are important for the interprretation of longitudinal studies evaluating the evolution of the SARS-CoV-2 in humans and development of new diagnostics, vaccine, and therapeutics targeting SARS-CoV-2.
References: PMID: 34305860 / doi: 10.3389/fmicb.2021.694897
Contact Info: Jungjoo Hong: hong75@kribb.re.kr; Bon-Sang Koo: porco9@kribb.re.kr
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2021.694897/full
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Korea Research Institute of Bioscience & Biotechnology, Chonnam National University, Chungbuk National University
Keywords: SARS-CoV-2, virus variants, microevolution, species specific variations, primates
Summary of Study: The genomes of SARS-CoV-2 differ according to individuals and species despite infection of the identical virus in NHPs. These results are important for the interprretation of longitudinal studies evaluating the evolution of the SARS-CoV-2 in humans and development of new diagnostics, vaccine, and therapeutics targeting SARS-CoV-2.
References: PMID: 34305860 / doi: 10.3389/fmicb.2021.694897
Contact Info: Jungjoo Hong: hong75@kribb.re.kr; Bon-Sang Koo: porco9@kribb.re.kr
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2021.694897/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Laboratory of Virology, Hamilton, MT; NIAID; University of Plymouth, Plymouth, UK; The Vaccine Group, Ltd.
Keywords: SARS-CoV-2, virus genomic variants, pathology, virus replication, shedding, primates
Summary of Study: Results from the intranasal AGM COVID-19 surrogate model support the most recent data from B.1.1.7 in humans, providing direct empirical data for increased replication in the respiratory tissue, but with no enhancement of disease.
References: PMID: 34724885 / doi: 10.1080/22221751.2021.1997074
Contact Info: Heinz Feldmann: feldmannh@niaid.nih.gov
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1997074
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Laboratory of Virology, Hamilton, MT; NIAID; University of Plymouth, Plymouth, UK; The Vaccine Group, Ltd.
Keywords: SARS-CoV-2, virus genomic variants, pathology, virus replication, shedding, primates
Summary of Study: Results from the intranasal AGM COVID-19 surrogate model support the most recent data from B.1.1.7 in humans, providing direct empirical data for increased replication in the respiratory tissue, but with no enhancement of disease.
References: PMID: 34724885 / doi: 10.1080/22221751.2021.1997074
Contact Info: Heinz Feldmann: feldmannh@niaid.nih.gov
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1997074
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Amsterdam, Universite Paris-Saclay, University of Southampton, and others
Keywords: SARS-CoV-2, two-component protein nanoparticle vaccine, primates
Summary of Study: A two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein induces potent neutralizing antibody responses in cynomolgus macaques. The vaccine-induced immunity protects macaques against a high-dose challenge, resulting in strongly reduced viral infection and replication in the upper and lower airways. These nanoparticles are a promising vaccine candidate.
References: PMID: 33577765 / doi: 10.1016/j.cell.2021.01.035
Contact Info: Roger Le Grand: roger.le-grand@cea.fr; Rogier Sanders: r.w.sanders@amsterdamumc.nl
URL: https://www.sciencedirect.com/science/article/pii/S0092867421000787?via%3Dihub=
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Amsterdam, Universite Paris-Saclay, University of Southampton, and others
Keywords: SARS-CoV-2, two-component protein nanoparticle vaccine, primates
Summary of Study: A two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein induces potent neutralizing antibody responses in cynomolgus macaques. The vaccine-induced immunity protects macaques against a high-dose challenge, resulting in strongly reduced viral infection and replication in the upper and lower airways. These nanoparticles are a promising vaccine candidate.
References: PMID: 33577765 / doi: 10.1016/j.cell.2021.01.035
Contact Info: Roger Le Grand: roger.le-grand@cea.fr; Rogier Sanders: r.w.sanders@amsterdamumc.nl
URL: https://www.sciencedirect.com/science/article/pii/S0092867421000787?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Institute of Human Virology, Zhongshan School of Medicine
Keywords: SARS-CoV-2, convalescent sera, receptor-binding domain based nanoparticles, virus variants, primates
Summary of Study: Results show that as mutations accumulate in the RBD, spike proteins may acquire an antigenic shift that enable SARS-CoV-2 variants to eventually resist the current vaccines. Intensive monitoring of virus mutations and timely adjustment of the designed vaccines are required to control the viral pandemic.
References: PMID: 33580167 / doi: 10.1038/s41423-021-00641-8
Contact Info: Xin He: hexin59@mail.sysu.edu.cn
URL: https://www.nature.com/articles/s41423-021-00641-8
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Institute of Human Virology, Zhongshan School of Medicine
Keywords: SARS-CoV-2, convalescent sera, receptor-binding domain based nanoparticles, virus variants, primates
Summary of Study: Results show that as mutations accumulate in the RBD, spike proteins may acquire an antigenic shift that enable SARS-CoV-2 variants to eventually resist the current vaccines. Intensive monitoring of virus mutations and timely adjustment of the designed vaccines are required to control the viral pandemic.
References: PMID: 33580167 / doi: 10.1038/s41423-021-00641-8
Contact Info: Xin He: hexin59@mail.sysu.edu.cn
URL: https://www.nature.com/articles/s41423-021-00641-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: California National Primate Research Center, UC Davis
Keywords: SARS-CoV-2, CD4 T follicular helper (Tfh) cells, primates
Summary of Study: SARC-CoV-2 infection in rhesus macaques, either infused with convalescent plasma, normal plasma, or receiving no infusion showed induction of germinal center (GC) responses.
References: PMID: 33483492 / doi: 10.1038/s41467-020-20642-x
Contact Info: Koen Van Rompay: kkvanrompay@ucdavis.edu; Smita Iyer: smiyer@ucdavis.edu
URL: https://www.nature.com/articles/s41467-020-20642-x
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: California National Primate Research Center, UC Davis
Keywords: SARS-CoV-2, CD4 T follicular helper (Tfh) cells, primates
Summary of Study: SARC-CoV-2 infection in rhesus macaques, either infused with convalescent plasma, normal plasma, or receiving no infusion showed induction of germinal center (GC) responses.
References: PMID: 33483492 / doi: 10.1038/s41467-020-20642-x
Contact Info: Koen Van Rompay: kkvanrompay@ucdavis.edu; Smita Iyer: smiyer@ucdavis.edu
URL: https://www.nature.com/articles/s41467-020-20642-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Karolinska Institute, University of Cape Town
Keywords: SARS-CoV-2, spike protein subunit vaccine, mice and primates, immune response
Summary of Study: Adjuvanted protein immunization with soluble SARS-CoV-2 Spike trimers, stabilized in prefusion conformation, results in potent antibody responses in mice and rhesus macaques, with neutralizing antibody titers exceeding those typically measured in SARS-CoV-2 seropositive humans by more than one order of magnitude.
References: PMID: 33842900 / doi: 10.1016/j.xcrm.2021.10052
Contact Info: Ben Murrell: benjamin.murrell@ki.se; Daniel Sheward: daniel.sheward@ki.se, Gunilla Karlsson Hedestam: gunilla.karlsson.hedestam@ki.se
URL: https://www.sciencedirect.com/science/article/pii/S2666379121000689?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Karolinska Institute, University of Cape Town
Keywords: SARS-CoV-2, spike protein subunit vaccine, mice and primates, immune response
Summary of Study: Adjuvanted protein immunization with soluble SARS-CoV-2 Spike trimers, stabilized in prefusion conformation, results in potent antibody responses in mice and rhesus macaques, with neutralizing antibody titers exceeding those typically measured in SARS-CoV-2 seropositive humans by more than one order of magnitude.
References: PMID: 33842900 / doi: 10.1016/j.xcrm.2021.10052
Contact Info: Ben Murrell: benjamin.murrell@ki.se; Daniel Sheward: daniel.sheward@ki.se, Gunilla Karlsson Hedestam: gunilla.karlsson.hedestam@ki.se
URL: https://www.sciencedirect.com/science/article/pii/S2666379121000689?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID; Emory University Vaccine Center; BIOQUAL; Moderna; Johns Hopkins University
Keywords: SARS-CoV-2, variants of concern, booster, immune response, primates
Summary of Study: An additional, delayed boost with mRNA vaccines matched to either the original vaccine strain or to the heterologous challenge strain can have a marked and sustained effect on increaseing the breadth of neutralization against all VOCs tested and protection in both the lower and upper airways against the beta variant.
References: PMID: 34672695 / doi: 10.1126/science.abl8912
Contact Info: Robert Seder: rseder@mail.nih.gov; Barney Graham: bgraham@nih.gov
URL: https://www.science.org/doi/10.1126/science.abl8912?url_ver=Z39.88-2003&rfr_id=…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID; Emory University Vaccine Center; BIOQUAL; Moderna; Johns Hopkins University
Keywords: SARS-CoV-2, variants of concern, booster, immune response, primates
Summary of Study: An additional, delayed boost with mRNA vaccines matched to either the original vaccine strain or to the heterologous challenge strain can have a marked and sustained effect on increaseing the breadth of neutralization against all VOCs tested and protection in both the lower and upper airways against the beta variant.
References: PMID: 34672695 / doi: 10.1126/science.abl8912
Contact Info: Robert Seder: rseder@mail.nih.gov; Barney Graham: bgraham@nih.gov
URL: https://www.science.org/doi/10.1126/science.abl8912?url_ver=Z39.88-2003&rfr_id=…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Washington; University of North Carolina at Chapel Hil; Fred Hutchinson Cancer Research Center; Stanford University School of Medicine; Institut Pasteur and CNRS UMR 3569; New Iberia Research Center and Department of Biology; Washington National Primate Research Center; University of Texas at Austin; GSK; Humabs Biomed SA; Bill & Melinda Gates Foundation\
Keywords: SARS-CoV-2, vaccine design, spike glycoprotein, receptor-binding domain, self-assembling nanoparticle, sarbecovirus, primates
Summary of Study: This study provides proof of the principle that multivalent sarbecovirus RBD-NPs induce heterotypic protection and motivates advancing such broadly protective sarbecovirus vaccines to the clinic.
References: PMID: 34619077 / doi: 10.1016/j.cell.2021.09.015
Contact Info: Neil King: neil@ipd.uw.edu; David Veesler: dveesler@uw.edu
URL: https://www.sciencedirect.com/science/article/pii/S009286742101062X?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Washington; University of North Carolina at Chapel Hil; Fred Hutchinson Cancer Research Center; Stanford University School of Medicine; Institut Pasteur and CNRS UMR 3569; New Iberia Research Center and Department of Biology; Washington National Primate Research Center; University of Texas at Austin; GSK; Humabs Biomed SA; Bill & Melinda Gates Foundation\
Keywords: SARS-CoV-2, vaccine design, spike glycoprotein, receptor-binding domain, self-assembling nanoparticle, sarbecovirus, primates
Summary of Study: This study provides proof of the principle that multivalent sarbecovirus RBD-NPs induce heterotypic protection and motivates advancing such broadly protective sarbecovirus vaccines to the clinic.
References: PMID: 34619077 / doi: 10.1016/j.cell.2021.09.015
Contact Info: Neil King: neil@ipd.uw.edu; David Veesler: dveesler@uw.edu
URL: https://www.sciencedirect.com/science/article/pii/S009286742101062X?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center, Tulane University School of Medicine, Tulane University, Brigham and Women's Hospital/Harvard Medical School, LSU Health Science Center, Julius-Maximilians-Universitat Wurzburg, and more
Keywords: SARS-CoV-2, endotheliopathy, inflammation, primates, mice
Summary of Study: In addition to pneumocytes, SARS-CoV-2 also directly infects mature vascular endothelial cells in vivo and ex vivo which may contribute to cardiovascular complications in SARS-CoV-2 infection, including multipleorgan failure.
References: PMID: 34307198 / doi: 10.3389/fcimb.2021.701278
Contact Info: Xuebin Qin: xqin2@tulane.edu; Suleyman Ergun: sueleyman.erguen@uni-wuerzburg.de
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292147/
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center, Tulane University School of Medicine, Tulane University, Brigham and Women's Hospital/Harvard Medical School, LSU Health Science Center, Julius-Maximilians-Universitat Wurzburg, and more
Keywords: SARS-CoV-2, endotheliopathy, inflammation, primates, mice
Summary of Study: In addition to pneumocytes, SARS-CoV-2 also directly infects mature vascular endothelial cells in vivo and ex vivo which may contribute to cardiovascular complications in SARS-CoV-2 infection, including multipleorgan failure.
References: PMID: 34307198 / doi: 10.3389/fcimb.2021.701278
Contact Info: Xuebin Qin: xqin2@tulane.edu; Suleyman Ergun: sueleyman.erguen@uni-wuerzburg.de
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292147/
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Huazhong University of Science & Technology; Chinese Academy of Sciences; Peking University; Shanghai Junshi Biosciences Co., Ltd.; and others
Keywords: SARS-CoV-2, ACE2-blocking monoclonal antibody, receptor-binding domain, pathology, primates
Summary of Study: The ACE2-blocking MAb represents a broadly promising therapeutic candidate against emergence, re-emergence, and future zoonotic transmission events from SARSr-CoVs and variants.
References: PMID: 34404805 / doi: 10.1038/s41467-021-25331-x
Contact Info: Wenjie Tan: tanwj@ivdc.chinacdc.cn
URL: https://www.nature.com/articles/s41467-021-25331-x
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Huazhong University of Science & Technology; Chinese Academy of Sciences; Peking University; Shanghai Junshi Biosciences Co., Ltd.; and others
Keywords: SARS-CoV-2, ACE2-blocking monoclonal antibody, receptor-binding domain, pathology, primates
Summary of Study: The ACE2-blocking MAb represents a broadly promising therapeutic candidate against emergence, re-emergence, and future zoonotic transmission events from SARSr-CoVs and variants.
References: PMID: 34404805 / doi: 10.1038/s41467-021-25331-x
Contact Info: Wenjie Tan: tanwj@ivdc.chinacdc.cn
URL: https://www.nature.com/articles/s41467-021-25331-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Ragon Institute of MGH, MIT and Harvard; UNC Chapel Hill; Tufts University; Janssen Vaccines & Prevention.
Keywords: SARS-CoV-2, adenovirus vectored COVID-19 vaccine, humoral and cellular immune responses, genome variants, primates
Summary of Study: The Ad26.COV2.S vaccine provided robust protection against both WA1/2020 and B.1.351 variants.
References: PMID: 34161961 / doi: 10.1038/s41586-021-03732-8
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.nature.com/articles/s41586-021-03732-8
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Ragon Institute of MGH, MIT and Harvard; UNC Chapel Hill; Tufts University; Janssen Vaccines & Prevention.
Keywords: SARS-CoV-2, adenovirus vectored COVID-19 vaccine, humoral and cellular immune responses, genome variants, primates
Summary of Study: The Ad26.COV2.S vaccine provided robust protection against both WA1/2020 and B.1.351 variants.
References: PMID: 34161961 / doi: 10.1038/s41586-021-03732-8
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.nature.com/articles/s41586-021-03732-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Erasmus Medical Center, Biomedical Primate Research Centre, Utrecht University, Friedrich-Loeffler-Institute, and others
Keywords: SARS-CoV-2, inactivated virus vaccine, immune response, pathology, mice, primates
Summary of Study: The surrogate virus-neutralization test (sVNT) detects high titers of RBD-binding antibodies and thus is potentially useful as an assay for large seroprevalence studies that aim at detecting high titers (vaccination trials or large-scale initial testing of potential animal reservoirs.)
References: PMID: 34458548 / doi: 10.1016/j.onehlt.2021.100313
Contact Info: Carmen Embregts: c.embregts@erasmusmc.nl; Corine GeurtsvanKessel: c. geurtsvankessel@erasmusmc.nl
URL: https://www.sciencedirect.com/science/article/pii/S2352771421001038?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Erasmus Medical Center, Biomedical Primate Research Centre, Utrecht University, Friedrich-Loeffler-Institute, and others
Keywords: SARS-CoV-2, inactivated virus vaccine, immune response, pathology, mice, primates
Summary of Study: The surrogate virus-neutralization test (sVNT) detects high titers of RBD-binding antibodies and thus is potentially useful as an assay for large seroprevalence studies that aim at detecting high titers (vaccination trials or large-scale initial testing of potential animal reservoirs.)
References: PMID: 34458548 / doi: 10.1016/j.onehlt.2021.100313
Contact Info: Carmen Embregts: c.embregts@erasmusmc.nl; Corine GeurtsvanKessel: c. geurtsvankessel@erasmusmc.nl
URL: https://www.sciencedirect.com/science/article/pii/S2352771421001038?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Russian Academy of Sciences; Sechenov First Moscow State Medical Univeristy; Lomonosov Moscow State University
Keywords: SARS-CoV-2, inactivated vaccine, long-term humoral immunogenicity, toxicity, mice, hamsters, primates
Summary of Study: A beta-propiolactone-inactivated whole virion vaccine (CoviVac) was asses and showed no signs of acute/chronic, reproductive, embryo- and fetotoxicity or teratogenic effects, as well as no allergenic properties in the animal species studied.
References: PMID: 34427172 / doi: 10.1080/22221751.2021.1971569
Contact Info: Liubov Kozlovskaya: lubov_i_k@mail.ru
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1971569
NHP Species: marmosets
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Russian Academy of Sciences; Sechenov First Moscow State Medical Univeristy; Lomonosov Moscow State University
Keywords: SARS-CoV-2, inactivated vaccine, long-term humoral immunogenicity, toxicity, mice, hamsters, primates
Summary of Study: A beta-propiolactone-inactivated whole virion vaccine (CoviVac) was asses and showed no signs of acute/chronic, reproductive, embryo- and fetotoxicity or teratogenic effects, as well as no allergenic properties in the animal species studied.
References: PMID: 34427172 / doi: 10.1080/22221751.2021.1971569
Contact Info: Liubov Kozlovskaya: lubov_i_k@mail.ru
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1971569
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: North Carolina State University; UNC-Chapel Hill; BreStem Therapeutics, Bioqual, Inc.
Keywords: SARS-CoV-2, ACE2 nanodecoys, inhalation therapy, mice and primates
Summary of Study: ACE2 nanodecoys derived from human lung spheroid cells (LSCs) can bind and neutralize SARS-CoV-2. In cynomolgus macaques challenged with live SARS-CoV-2, four doses of these nanodecoys delivered by inhalation promoted viral clearance and reduced lung injury. these results suggest that LSC-nanodecoys can serve as a potential therapeutic agent for treating COVID-19.
References: PMID: 34140674 / doi: 10.1038/s41565-021-00923-2
Contact Info: Ke Cheng: ke_cheng@ncsu.edu
URL: https://www.nature.com/articles/s41565-021-00923-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: North Carolina State University; UNC-Chapel Hill; BreStem Therapeutics, Bioqual, Inc.
Keywords: SARS-CoV-2, ACE2 nanodecoys, inhalation therapy, mice and primates
Summary of Study: ACE2 nanodecoys derived from human lung spheroid cells (LSCs) can bind and neutralize SARS-CoV-2. In cynomolgus macaques challenged with live SARS-CoV-2, four doses of these nanodecoys delivered by inhalation promoted viral clearance and reduced lung injury. these results suggest that LSC-nanodecoys can serve as a potential therapeutic agent for treating COVID-19.
References: PMID: 34140674 / doi: 10.1038/s41565-021-00923-2
Contact Info: Ke Cheng: ke_cheng@ncsu.edu
URL: https://www.nature.com/articles/s41565-021-00923-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Harvard Univ., MIT, Tulane National Primate Research Center
Keywords: SARS-CoV-2, respiratory droplet generation and exhalation, primates
Summary of Study: The proportion of small respiratory droplets (the majority of particles exhaled in all subjects) increased at the peak of COVID-19 infection in NHPs. This confirms a previously published observation from the exhaled aerosol profile of a single COVID-19 positive human subject, and suggests that, at peak infection, there may be an elevated risk of the airborne transmission of SARS-CoV-2 by way of the very small droplets that transmit through conventional masks and travers distances far exceeding the conventional social distance of 2 m.
References: PMID: 33563754 / doi: 10.1073/pnas.2021830118
Contact Info: David Edwards: dedwards@seas.harvard.edu; Chad Roy: croy@tulane.edu
URL: https://www.pnas.org/content/118/8/e2021830118.long
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Harvard Univ., MIT, Tulane National Primate Research Center
Keywords: SARS-CoV-2, respiratory droplet generation and exhalation, primates
Summary of Study: The proportion of small respiratory droplets (the majority of particles exhaled in all subjects) increased at the peak of COVID-19 infection in NHPs. This confirms a previously published observation from the exhaled aerosol profile of a single COVID-19 positive human subject, and suggests that, at peak infection, there may be an elevated risk of the airborne transmission of SARS-CoV-2 by way of the very small droplets that transmit through conventional masks and travers distances far exceeding the conventional social distance of 2 m.
References: PMID: 33563754 / doi: 10.1073/pnas.2021830118
Contact Info: David Edwards: dedwards@seas.harvard.edu; Chad Roy: croy@tulane.edu
URL: https://www.pnas.org/content/118/8/e2021830118.long
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Karolinska Institutet; University of Cape Town
Keywords: SARS-CoV-2, virus genomic variants, antigenic sin, boost, passive immunization, mice, primates
Summary of Study: A single dose of adjuvanted beta variant receptor binding domain (RBD) protein broadens neutralizing antibody responses to heterologous VOCs.
References: PMID: 34723224 / doi: 10.1016/j.xcrm.2021.100450
Contact Info: Daniel Sheward: daniel.sheward@ki.se; Gunilla Karlsson Hedestam: gunilla.karlsson.hedestam@ki.se; Ben Murrell: benjamin.murrell@ki.se
URL: https://www.sciencedirect.com/science/article/pii/S2666379121003189?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Karolinska Institutet; University of Cape Town
Keywords: SARS-CoV-2, virus genomic variants, antigenic sin, boost, passive immunization, mice, primates
Summary of Study: A single dose of adjuvanted beta variant receptor binding domain (RBD) protein broadens neutralizing antibody responses to heterologous VOCs.
References: PMID: 34723224 / doi: 10.1016/j.xcrm.2021.100450
Contact Info: Daniel Sheward: daniel.sheward@ki.se; Gunilla Karlsson Hedestam: gunilla.karlsson.hedestam@ki.se; Ben Murrell: benjamin.murrell@ki.se
URL: https://www.sciencedirect.com/science/article/pii/S2666379121003189?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Copycat Sciences; Sporos Bioventures
Keywords: SARS-CoV-2, redelivery, analysis of the preclinical data and clinical efficacy, primates
Summary of Study: The gap between the strong preclinical data with remdesivir (RDV) across many virus models and its questionable clinical activitiy suggests that assumptions are being made at the preclinical level that do not reflect the conditions observed in patients.
References: PMID: 34252308 / doi: 10.1128/AAC.01117-21
Contact Info: Victoria Yan: victoria.yan@copycatsciences.com
URL: https://journals.asm.org/doi/10.1128/AAC.01117-21?url_ver=Z39.88-2003&rfr_id=or…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Copycat Sciences; Sporos Bioventures
Keywords: SARS-CoV-2, redelivery, analysis of the preclinical data and clinical efficacy, primates
Summary of Study: The gap between the strong preclinical data with remdesivir (RDV) across many virus models and its questionable clinical activitiy suggests that assumptions are being made at the preclinical level that do not reflect the conditions observed in patients.
References: PMID: 34252308 / doi: 10.1128/AAC.01117-21
Contact Info: Victoria Yan: victoria.yan@copycatsciences.com
URL: https://journals.asm.org/doi/10.1128/AAC.01117-21?url_ver=Z39.88-2003&rfr_id=or…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: USC, , UCLA, City of Hope, Bioqual
Keywords: SARS-CoV-2, pancreatic beta cells, toxicity, metabolism, primates
Summary of Study: SARS-CoV-2 infection enhances beta cell stress that may compromise beta-cell function beyond the duration of the disease course, raising the possibility that the beta cell stress and injury may have clinical implications to the long-term future health of patients that have recovered from COVID19.
References: PMID: 34312617 / doi: 10.21203/rs.3.rs-592374/v1
Contact Info: Senta Georgia: sgeorgia@chla.usc.edu
URL: https://www.researchsquare.com/article/rs-592374/v1
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: USC, , UCLA, City of Hope, Bioqual
Keywords: SARS-CoV-2, pancreatic beta cells, toxicity, metabolism, primates
Summary of Study: SARS-CoV-2 infection enhances beta cell stress that may compromise beta-cell function beyond the duration of the disease course, raising the possibility that the beta cell stress and injury may have clinical implications to the long-term future health of patients that have recovered from COVID19.
References: PMID: 34312617 / doi: 10.21203/rs.3.rs-592374/v1
Contact Info: Senta Georgia: sgeorgia@chla.usc.edu
URL: https://www.researchsquare.com/article/rs-592374/v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Universite Paris-Saclay, Inserm; Pereman School of Medicine; Novartis Gene Therapies; Boston University School of Medicine; Institute Pasteur; Mass General Brigham Innovation; Albamunity
Keywords: SARS-CoV-2, AAV-based vaccine, immunogenicity, thermostability, mice, primates
Summary of Study: AAVrh32.33 technology demonstrated its utilitiy as a preventative vaccine for COVID19, and its unique attributes may be applicable to other pathogens or immunization targets.
References: PMID: 34428428 / doi: 10.1016/j.chom.2021.08.002
Contact Info: Luk Vandenberghe: luk_vandenberghe@meei.harvard.edu; Roger Le Grand: roger.le-grand@cea.fr
URL: https://www.sciencedirect.com/science/article/pii/S1931312821003784?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Universite Paris-Saclay, Inserm; Pereman School of Medicine; Novartis Gene Therapies; Boston University School of Medicine; Institute Pasteur; Mass General Brigham Innovation; Albamunity
Keywords: SARS-CoV-2, AAV-based vaccine, immunogenicity, thermostability, mice, primates
Summary of Study: AAVrh32.33 technology demonstrated its utilitiy as a preventative vaccine for COVID19, and its unique attributes may be applicable to other pathogens or immunization targets.
References: PMID: 34428428 / doi: 10.1016/j.chom.2021.08.002
Contact Info: Luk Vandenberghe: luk_vandenberghe@meei.harvard.edu; Roger Le Grand: roger.le-grand@cea.fr
URL: https://www.sciencedirect.com/science/article/pii/S1931312821003784?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Stanford Univ. SOM, Univ. of Washington, Tulane National Primate Research Center, Yerkes National Primate Research Center, and others
Keywords: SARS-CoV-2, subunit vaccine, immune response, primates
Summary of Study: Data highlighted the efficacy of the adjuvanted RBD-NP vaccine in promoting protective immunity against SARS-Cov-2 and have led to phase I/II clinical trials of this vaccine.
References: PMID: 33873199 / doi: 10.1038/s41586-021-03530-2
Contact Info: Bali Pulendran: bpulend@stanford.edu;
URL: https://www.nature.com/articles/s41586-021-03530-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Stanford Univ. SOM, Univ. of Washington, Tulane National Primate Research Center, Yerkes National Primate Research Center, and others
Keywords: SARS-CoV-2, subunit vaccine, immune response, primates
Summary of Study: Data highlighted the efficacy of the adjuvanted RBD-NP vaccine in promoting protective immunity against SARS-Cov-2 and have led to phase I/II clinical trials of this vaccine.
References: PMID: 33873199 / doi: 10.1038/s41586-021-03530-2
Contact Info: Bali Pulendran: bpulend@stanford.edu;
URL: https://www.nature.com/articles/s41586-021-03530-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences, Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)
Keywords: SARS-CoV-2, immunopathology, young and old animals, primates
Summary of Study: Results showed that the age-related immune microenvironment in the lungs, spleens, PBMCs , and CD8+ cells significantly affected the immunopathology of SARS-CoV-2 infection, whereas the increase in inflammatory factor-secreting cells in the lungs and systemic accumulation of CXCR3+ cells are associated with necrosis and inflammatory activation of ACE2+ lung cells.
References: PMID: 34471088 / doi: 10.1038/s41392-021-00734-w
Contact Info: Yong-Tang Zheng: zhengyt@mail.kiz.ac.cn
URL: https://www.nature.com/articles/s41392-021-00734-w
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences, Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)
Keywords: SARS-CoV-2, immunopathology, young and old animals, primates
Summary of Study: Results showed that the age-related immune microenvironment in the lungs, spleens, PBMCs , and CD8+ cells significantly affected the immunopathology of SARS-CoV-2 infection, whereas the increase in inflammatory factor-secreting cells in the lungs and systemic accumulation of CXCR3+ cells are associated with necrosis and inflammatory activation of ACE2+ lung cells.
References: PMID: 34471088 / doi: 10.1038/s41392-021-00734-w
Contact Info: Yong-Tang Zheng: zhengyt@mail.kiz.ac.cn
URL: https://www.nature.com/articles/s41392-021-00734-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Institut Pasteur; Sorbonne Universite; Ecole normale superieure Paris-Saclay; Universite de Paris
Keywords: SARS-CoV-2, therapeutics, vaccine, pathogenesis, drug discovery, animal model, primates
Summary of Study: This review discusses the use of NHPs as models for COVID-19 research, with focus on the pathogenesis of SARS-CoV-2 infection, drug discovery and pre-clinical evaluation of vaccine candidates.
References: PMID: 34452011 / doi: 10.3390/vaccines9080886
Contact Info: Caroline Passaes: caroline.pereira-bittencourt@pasteur.fr
URL: https://www.mdpi.com/2076-393X/9/8/886
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Institut Pasteur; Sorbonne Universite; Ecole normale superieure Paris-Saclay; Universite de Paris
Keywords: SARS-CoV-2, therapeutics, vaccine, pathogenesis, drug discovery, animal model, primates
Summary of Study: This review discusses the use of NHPs as models for COVID-19 research, with focus on the pathogenesis of SARS-CoV-2 infection, drug discovery and pre-clinical evaluation of vaccine candidates.
References: PMID: 34452011 / doi: 10.3390/vaccines9080886
Contact Info: Caroline Passaes: caroline.pereira-bittencourt@pasteur.fr
URL: https://www.mdpi.com/2076-393X/9/8/886
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Janssen Vaccines, Leiden University Medical Center, Harvard Medical School
Keywords: SARS-CoV-2, adenovirus vectored COVID-19 vaccine, immune response, pathology, primates
Summary of Study: The immunogenicity, protective efficacy, and SARS-CoV-2 spike variant neutralizing data presented in this manuscript further support the decision to evaluate a single 5 x 10^10-vp dose of Ad26.COV2.S in Phase 3 trials.
References: PMID: 33909009 / doi: 10.1084/jem.20202756
Contact Info: Roland Zahn: rzahn@its.jnj.com
URL: https://rupress.org/jem/article/218/7/e20202756/212032/Immunogenicity-and-effic…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Janssen Vaccines, Leiden University Medical Center, Harvard Medical School
Keywords: SARS-CoV-2, adenovirus vectored COVID-19 vaccine, immune response, pathology, primates
Summary of Study: The immunogenicity, protective efficacy, and SARS-CoV-2 spike variant neutralizing data presented in this manuscript further support the decision to evaluate a single 5 x 10^10-vp dose of Ad26.COV2.S in Phase 3 trials.
References: PMID: 33909009 / doi: 10.1084/jem.20202756
Contact Info: Roland Zahn: rzahn@its.jnj.com
URL: https://rupress.org/jem/article/218/7/e20202756/212032/Immunogenicity-and-effic…
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: United States Army Medical Research Institute of Infectious Diseases
Keywords: SARS-CoV-2, comparative evaluation of disease progression in three primate species
Summary of Study: In addition to African green monkeys, macaques can be successfully infected by airborne SARS-CoV-2, providing viable macaque natural transmission models for medical countermeasure evaluation.
References: PMID: 33529233 / doi: 10.1371/journal.pone.0246366
Contact Info: Sara Johnston: sara.c.johnston2.civ@mail.mil; Aysegul Nalca: aysegul.nalca.civ@mail.mil
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0246366
NHP Species: african green monkeys, rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: United States Army Medical Research Institute of Infectious Diseases
Keywords: SARS-CoV-2, comparative evaluation of disease progression in three primate species
Summary of Study: In addition to African green monkeys, macaques can be successfully infected by airborne SARS-CoV-2, providing viable macaque natural transmission models for medical countermeasure evaluation.
References: PMID: 33529233 / doi: 10.1371/journal.pone.0246366
Contact Info: Sara Johnston: sara.c.johnston2.civ@mail.mil; Aysegul Nalca: aysegul.nalca.civ@mail.mil
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0246366
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre (BPRC); Utrecht University
Keywords: SARS-CoV-2, chest CT, ultrasound, pulmonary lesions, primates
Summary of Study: As has been observed in humans, the sensitivity of lung ultrasound (LUS) is high though the diagnostic efficacy or mild-to-moderate disease is relatively low. The low efficacy outweighs the advantages of LUS over CT (i.e. no need to transport the animals and the absence of ionizing radiation). For this reason, CT is still the imaging modality of choice for diagnosis, monitoring, and longitudinal assessment of a SARS-CoV-2 infection in NHPs.
References: PMID: 34778433 / doi: 10.3389/fvets.2021.748635
Contact Info: Marieke Stammes: stammes@bprc.nl
URL: https://www.frontiersin.org/articles/10.3389/fvets.2021.748635/full
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre (BPRC); Utrecht University
Keywords: SARS-CoV-2, chest CT, ultrasound, pulmonary lesions, primates
Summary of Study: As has been observed in humans, the sensitivity of lung ultrasound (LUS) is high though the diagnostic efficacy or mild-to-moderate disease is relatively low. The low efficacy outweighs the advantages of LUS over CT (i.e. no need to transport the animals and the absence of ionizing radiation). For this reason, CT is still the imaging modality of choice for diagnosis, monitoring, and longitudinal assessment of a SARS-CoV-2 infection in NHPs.
References: PMID: 34778433 / doi: 10.3389/fvets.2021.748635
Contact Info: Marieke Stammes: stammes@bprc.nl
URL: https://www.frontiersin.org/articles/10.3389/fvets.2021.748635/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Department of Virology, Aggeu Magalhaes Institute, Brazil
Keywords: SARS-CoV-2, in vitro and in vivo models, several animal species, including primates, review
Summary of Study: This review article summarizes the main models of SARS-CoV-2 infection developed so far and discusses their advantages, drawbacks and main uses.
References: PMID: 33673614 / doi: 10.3390/v13030379
Contact Info: Lindomar Pena: lindomar.pena@cpqam.fiocruz.br
URL: https://www.mdpi.com/1999-4915/13/3/379/htm
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Department of Virology, Aggeu Magalhaes Institute, Brazil
Keywords: SARS-CoV-2, in vitro and in vivo models, several animal species, including primates, review
Summary of Study: This review article summarizes the main models of SARS-CoV-2 infection developed so far and discusses their advantages, drawbacks and main uses.
References: PMID: 33673614 / doi: 10.3390/v13030379
Contact Info: Lindomar Pena: lindomar.pena@cpqam.fiocruz.br
URL: https://www.mdpi.com/1999-4915/13/3/379/htm
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences
Keywords: SARS-CoV-2, combined intratracheal and intranasal inoculation, virus load, primates
Summary of Study: Nasal infection may be regarded as an important index to assess the severity of COVID-19. Furthermore, treatments focused on nasal infection, like hypertonic saline nasal irrigation and gargling, should be considered as a therapeutic option for COVID-19.
References: PMID: 33587263 / doi: 10.1007/s11427-020-1877-4
Contact Info: Yong-Tang Zheng: zhengyt@mail.kiz.ac.cn
URL: https://link.springer.com/article/10.1007%2Fs11427-020-1877-4
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences
Keywords: SARS-CoV-2, combined intratracheal and intranasal inoculation, virus load, primates
Summary of Study: Nasal infection may be regarded as an important index to assess the severity of COVID-19. Furthermore, treatments focused on nasal infection, like hypertonic saline nasal irrigation and gargling, should be considered as a therapeutic option for COVID-19.
References: PMID: 33587263 / doi: 10.1007/s11427-020-1877-4
Contact Info: Yong-Tang Zheng: zhengyt@mail.kiz.ac.cn
URL: https://link.springer.com/article/10.1007%2Fs11427-020-1877-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, primates, animal resources, biosafety
Summary of Study: Sustaining and increasing NHP research capacity will require careful preparation and collaborations to improve existing infrastructure and expand established facilities, expertise, and programs.
References: PMID: 33927412 / doi: 10.1038/s41684-021-00760-9
Contact Info: Sheri Ann Hild: sheri.hild@nih.gov
URL: https://www.nature.com/articles/s41684-021-00760-9
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, primates, animal resources, biosafety
Summary of Study: Sustaining and increasing NHP research capacity will require careful preparation and collaborations to improve existing infrastructure and expand established facilities, expertise, and programs.
References: PMID: 33927412 / doi: 10.1038/s41684-021-00760-9
Contact Info: Sheri Ann Hild: sheri.hild@nih.gov
URL: https://www.nature.com/articles/s41684-021-00760-9