Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: China Biotechnology Co.LTD; Beijing Chaoyang Hospital, Capital Medical University; Laboratory Animal Center, Academy of Military Medical Sciences
Keywords: SARS-CoV-2, angiotensin-converting enzyme 2, gene sequences, primates
Summary of Study: Angiotensin-converting enzyme (ACE2) binds to the SARS-CoV2 virus as a receptor, and variation of the ACE2 sequence and binding affinity may account for differences in susceptibility and responses to infection
References: PMID: 36105891 / doi: 10.1016/j.bsheal.2022.09.001
Contact Info: Xiaojun Zhou, Jingjing Zhao, Yefeng Qiu, Rui Jia
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461283/
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: China Biotechnology Co.LTD; Beijing Chaoyang Hospital, Capital Medical University; Laboratory Animal Center, Academy of Military Medical Sciences
Keywords: SARS-CoV-2, angiotensin-converting enzyme 2, gene sequences, primates
Summary of Study: Angiotensin-converting enzyme (ACE2) binds to the SARS-CoV2 virus as a receptor, and variation of the ACE2 sequence and binding affinity may account for differences in susceptibility and responses to infection
References: PMID: 36105891 / doi: 10.1016/j.bsheal.2022.09.001
Contact Info: Xiaojun Zhou, Jingjing Zhao, Yefeng Qiu, Rui Jia
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461283/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Respiratory Disease, China; Guanzhou Laboratory, China; University of Science and Technology Hong Kong, numerous others
Keywords: SARS-CoV-2, spike protein vaccine, immune response, virus variants, mice, primates
Summary of Study: RBMRNA-176 is a vaccine candidate for prevention of COVID-19
References: doi: 10.3390/vaccines10101698
Contact Info: Wei Yang: [email protected]
URL: https://www.mdpi.com/2076-393X/10/10/1698
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Respiratory Disease, China; Guanzhou Laboratory, China; University of Science and Technology Hong Kong, numerous others
Keywords: SARS-CoV-2, spike protein vaccine, immune response, virus variants, mice, primates
Summary of Study: RBMRNA-176 is a vaccine candidate for prevention of COVID-19
References: doi: 10.3390/vaccines10101698
Contact Info: Wei Yang: [email protected]
URL: https://www.mdpi.com/2076-393X/10/10/1698
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID Laboratory of Virology and NIAID Rocky Mountain Veterinary Branch, Hamilton, MT
Keywords: SARS-CoV-2, pathology, virus variants, primates
Summary of Study: Omicron BA.1 and BA.2 are attenuated in rhesus macaques as compared to Delta
References: doi: 10.1126/sciadv.ade1860
Contact Info: Kyle Rosenke: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.ade1860
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID Laboratory of Virology and NIAID Rocky Mountain Veterinary Branch, Hamilton, MT
Keywords: SARS-CoV-2, pathology, virus variants, primates
Summary of Study: Omicron BA.1 and BA.2 are attenuated in rhesus macaques as compared to Delta
References: doi: 10.1126/sciadv.ade1860
Contact Info: Kyle Rosenke: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.ade1860
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center, Texas Biomedical Research Institute; Washington University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, longitudinal scRNAseq, bronchoalveolar lavage, immune response, primates
Summary of Study: Results unequivocally show that in protected, immunocompetent hosts, SARS-CoV-2 infection is characterized by an acute inflammatory response leading to a myeloid cell influx into the lung compartment. Induction of a robust IFN response in macrophages strongly correlates with viremia and subsequent clearance of SARS-CoV-2 from the airways of macaques.
References: PMID: 35115549 / doi: 10.1038/s41467-022-28315-7
Contact Info: Maxim Artyomov: [email protected]
URL: https://www.nature.com/articles/s41467-022-28315-7
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center, Texas Biomedical Research Institute; Washington University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, longitudinal scRNAseq, bronchoalveolar lavage, immune response, primates
Summary of Study: Results unequivocally show that in protected, immunocompetent hosts, SARS-CoV-2 infection is characterized by an acute inflammatory response leading to a myeloid cell influx into the lung compartment. Induction of a robust IFN response in macrophages strongly correlates with viremia and subsequent clearance of SARS-CoV-2 from the airways of macaques.
References: PMID: 35115549 / doi: 10.1038/s41467-022-28315-7
Contact Info: Maxim Artyomov: [email protected]
URL: https://www.nature.com/articles/s41467-022-28315-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Sun Yat-sen University; Guangdong Academy of Medical Sciences; Qianyang Biomedical Research Institute; Guangdong Provincial Center for Disease Control and Prevention
Keywords: SARS-CoV-2, Receptor Binding Domain (RBD)-Conjugated Nanoparticle Vaccine, virus variants, hACE2 mice, primates
Summary of Study: RBD-based monovalent or multivalent nanoparticle vaccines provide a promising second-generation vaccine strategy for SARS-CoV-2 variants.
References: PMID: 35142444 / doi: 10.1002/advs.202105378
Contact Info: Ting Pan: [email protected]; Hui Zhang: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008796/
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Sun Yat-sen University; Guangdong Academy of Medical Sciences; Qianyang Biomedical Research Institute; Guangdong Provincial Center for Disease Control and Prevention
Keywords: SARS-CoV-2, Receptor Binding Domain (RBD)-Conjugated Nanoparticle Vaccine, virus variants, hACE2 mice, primates
Summary of Study: RBD-based monovalent or multivalent nanoparticle vaccines provide a promising second-generation vaccine strategy for SARS-CoV-2 variants.
References: PMID: 35142444 / doi: 10.1002/advs.202105378
Contact Info: Ting Pan: [email protected]; Hui Zhang: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008796/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Universite Paris-Saclay, Inserm, CEA; University of Amsterdam; Grousbeck Gene Therapy Center; Harvard Medical School; The Broad Institute of Harvard and MIT; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, computed X-ray tomography and [18F]-FDG positron emission tomography, pathology, primates
Summary of Study: CT, combined with [18F]-FDG PET imaging, to study SARS-CoV-2 infected NHPs, can produce strong and transposable readouts to monitor COVID-19 disease as well as the efficacy of future treatments and vaccine candidates.
References: PMID: 35313622 / doi: 10.1016/j.isci.2022.104101
Contact Info: Thibaut Naninck: [email protected]
URL: https://www.cell.com/iscience/fulltext/S2589-0042(22)00371-6?_returnURL=https%3…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Universite Paris-Saclay, Inserm, CEA; University of Amsterdam; Grousbeck Gene Therapy Center; Harvard Medical School; The Broad Institute of Harvard and MIT; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, computed X-ray tomography and [18F]-FDG positron emission tomography, pathology, primates
Summary of Study: CT, combined with [18F]-FDG PET imaging, to study SARS-CoV-2 infected NHPs, can produce strong and transposable readouts to monitor COVID-19 disease as well as the efficacy of future treatments and vaccine candidates.
References: PMID: 35313622 / doi: 10.1016/j.isci.2022.104101
Contact Info: Thibaut Naninck: [email protected]
URL: https://www.cell.com/iscience/fulltext/S2589-0042(22)00371-6?_returnURL=https%3…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of California, Davis, School of Medicine
Keywords: SARS-CoV-2, pre-existing HIV infection, gene expression, metabolomics, primates
Summary of Study: SIV infection resulted in sustained or increased ACE2 expression in an inflamed and immune-impaired gut mucosal microenvironment.
References: PMID: 35495669 / doi: 10.3389/fmicb.2022.879152
Contact Info: Satya Dandekar: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2022.879152/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of California, Davis, School of Medicine
Keywords: SARS-CoV-2, pre-existing HIV infection, gene expression, metabolomics, primates
Summary of Study: SIV infection resulted in sustained or increased ACE2 expression in an inflamed and immune-impaired gut mucosal microenvironment.
References: PMID: 35495669 / doi: 10.3389/fmicb.2022.879152
Contact Info: Satya Dandekar: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2022.879152/full
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Cellid Co., Ltd; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology; International Vaccine Institute; Seoul National University
Keywords: SARS-CoV-2, adenovirus, AdCLD-CoV19 vaccine, immune response, virus variants, primates
Summary of Study: AdCLD-CoV19 can prevent SARS-CoV-2 with a single vaccination, and the new vaccine administration strategy that responds to various variants can maintain the efficacy of the vaccine.
References: PMID: 35632468 / doi: 10.3390/vaccines10050712
Contact Info: Chang-Yuil Kang: [email protected]
URL: https://www.mdpi.com/2076-393X/10/5/712
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Cellid Co., Ltd; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology; International Vaccine Institute; Seoul National University
Keywords: SARS-CoV-2, adenovirus, AdCLD-CoV19 vaccine, immune response, virus variants, primates
Summary of Study: AdCLD-CoV19 can prevent SARS-CoV-2 with a single vaccination, and the new vaccine administration strategy that responds to various variants can maintain the efficacy of the vaccine.
References: PMID: 35632468 / doi: 10.3390/vaccines10050712
Contact Info: Chang-Yuil Kang: [email protected]
URL: https://www.mdpi.com/2076-393X/10/5/712
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Bordeaux; Université Paris-Saclay; Vaccine Research Institute Créteil; Inserm U955 Créteil; Baylor Scott and White Research Institute; Institut Pasteur Paris; CNRS UMR 3569; University of Amsterdam Amsterdam Infection & Immunity Institute Amsterdam; Hôpital Henri-Mondor Albert-Chenevier; CHU Bordeaux
Keywords: SARS-CoV-2, mathematical modelling, vaccine, viral dynamics, primates
Summary of Study: A model-based approach can identify mechanistic correlates of protection that vaccines provide against infection, such that inhibition of the receptor-binding domain to ACE2 represents a strong mechanism of protection.
References: PMID: 35801637 / doi: 10.7554/eLife.75427
Contact Info: Rodolphe Thiébaut: [email protected]
URL: https://elifesciences.org/articles/75427
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Bordeaux; Université Paris-Saclay; Vaccine Research Institute Créteil; Inserm U955 Créteil; Baylor Scott and White Research Institute; Institut Pasteur Paris; CNRS UMR 3569; University of Amsterdam Amsterdam Infection & Immunity Institute Amsterdam; Hôpital Henri-Mondor Albert-Chenevier; CHU Bordeaux
Keywords: SARS-CoV-2, mathematical modelling, vaccine, viral dynamics, primates
Summary of Study: A model-based approach can identify mechanistic correlates of protection that vaccines provide against infection, such that inhibition of the receptor-binding domain to ACE2 represents a strong mechanism of protection.
References: PMID: 35801637 / doi: 10.7554/eLife.75427
Contact Info: Rodolphe Thiébaut: [email protected]
URL: https://elifesciences.org/articles/75427
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: National Institutes for Food and Drug Control, Beijing; Chinese Academy of Medicine Sciences & Peking Union Medical College; Guangzhou Laboratory; Kunming National High-level Biosafety Primate Research Center
Keywords: SARS-CoV-2, virus variants, virulence, pathogenesis, immune response, primates
Summary of Study: Pathogenic differences of ancestral SARS-CoV-2 strain and a beta variant found the variant resulted in more severe lung injury and an elevated level of inflammatory cytokines, but a lower transmission ability.
References: PMID: 36069561 / doi: 10.1128/spectrum.02263-22
Contact Info: Junzhi Wang: [email protected]; Miao Xu: [email protected]
URL: https://journals.asm.org/doi/full/10.1128/spectrum.02263-22?rfr_dat=cr_pub++0pu…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: National Institutes for Food and Drug Control, Beijing; Chinese Academy of Medicine Sciences & Peking Union Medical College; Guangzhou Laboratory; Kunming National High-level Biosafety Primate Research Center
Keywords: SARS-CoV-2, virus variants, virulence, pathogenesis, immune response, primates
Summary of Study: Pathogenic differences of ancestral SARS-CoV-2 strain and a beta variant found the variant resulted in more severe lung injury and an elevated level of inflammatory cytokines, but a lower transmission ability.
References: PMID: 36069561 / doi: 10.1128/spectrum.02263-22
Contact Info: Junzhi Wang: [email protected]; Miao Xu: [email protected]
URL: https://journals.asm.org/doi/full/10.1128/spectrum.02263-22?rfr_dat=cr_pub++0pu…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Keio University School of Medicine, Tokyo, Japan; RIKEN Center for Integrative Medical Sciences, Infectious Diseases Research unit, Kanagawa, Japan, numerous others.
Keywords: SARS-CoV-2, therapeutic neutralizing antibodies, virus variants, immune response, hamsters, primates
Summary of Study: Potent SARS-CoV-2 neutralizing antibodies with therapeutic effects
References: doi: 10.1016/j.isci.2022.105596
Contact Info: Masaru Takeshita: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2589004222018685?via%3Dihub
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Keio University School of Medicine, Tokyo, Japan; RIKEN Center for Integrative Medical Sciences, Infectious Diseases Research unit, Kanagawa, Japan, numerous others.
Keywords: SARS-CoV-2, therapeutic neutralizing antibodies, virus variants, immune response, hamsters, primates
Summary of Study: Potent SARS-CoV-2 neutralizing antibodies with therapeutic effects
References: doi: 10.1016/j.isci.2022.105596
Contact Info: Masaru Takeshita: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2589004222018685?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre/The Netherlands; NIAID; University Paris-Saclay, Inserm; Tulane National Primate Research Center; University of Pittsburgh School of Medicine; University of Pittsburgh Center for Vaccine Research; Texas Biomedical Research Institute; Frederick National Laboratory for Cancer Research
Keywords: SARS-CoV-2, advanced medical imaging, pathogenesis, primates
Summary of Study: The reviewers argue that advanced imaging tools add unique insight into poorly understood relationships of SARS-CV-2 exposure, infection, the host response, and disease presentation in the lungs.
References: PMID: 34955425 / doi: 10.1016/j.molmed.2021.12.001
Contact Info: Marieke Stammes: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1471491421003166?via%3Dihub
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre/The Netherlands; NIAID; University Paris-Saclay, Inserm; Tulane National Primate Research Center; University of Pittsburgh School of Medicine; University of Pittsburgh Center for Vaccine Research; Texas Biomedical Research Institute; Frederick National Laboratory for Cancer Research
Keywords: SARS-CoV-2, advanced medical imaging, pathogenesis, primates
Summary of Study: The reviewers argue that advanced imaging tools add unique insight into poorly understood relationships of SARS-CV-2 exposure, infection, the host response, and disease presentation in the lungs.
References: PMID: 34955425 / doi: 10.1016/j.molmed.2021.12.001
Contact Info: Marieke Stammes: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1471491421003166?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Zhongshan School of Medicine; Qianyang Biomedical Research Institute; Guangdong Provincial Center for Disease Control and Prevention
Keywords: SARS-CoV-2, bivalent vaccine, D614G/B.1.351, vaccine dosage, mice, primates
Summary of Study: With a prime-boost or single-dose strategy a bivalent D614G/B.1.351 RBD nanoparticle vaccine elicited robust nAbs and full protection against infection with the authentic D614 or B.1.351 strains in human ACE2 transgene mice. Furthermore, 8 months after inoculation with the D614G-specific vaccine, a new boost with this bivalent vaccine potently elicited cross-nAbs for SARS-CoV-2 variants in rhesus macaques.
References: PMID: 34990583 / doi: 10.1016/j.celrep.2021.110256
Contact Info: Yiwen Zhang: [email protected]; Hui Zhang: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S221112472101768X?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Zhongshan School of Medicine; Qianyang Biomedical Research Institute; Guangdong Provincial Center for Disease Control and Prevention
Keywords: SARS-CoV-2, bivalent vaccine, D614G/B.1.351, vaccine dosage, mice, primates
Summary of Study: With a prime-boost or single-dose strategy a bivalent D614G/B.1.351 RBD nanoparticle vaccine elicited robust nAbs and full protection against infection with the authentic D614 or B.1.351 strains in human ACE2 transgene mice. Furthermore, 8 months after inoculation with the D614G-specific vaccine, a new boost with this bivalent vaccine potently elicited cross-nAbs for SARS-CoV-2 variants in rhesus macaques.
References: PMID: 34990583 / doi: 10.1016/j.celrep.2021.110256
Contact Info: Yiwen Zhang: [email protected]; Hui Zhang: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S221112472101768X?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Institute de Biologie Structurale; Universite Paris-Saclay, Inserm, CEA; Amsterdam University Medical Centers; Institute Pasteur, Universite de Paris; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, vaccine candidate, synthetic spike (S) glycoprotein-coated lipid vesicles, immune response, primates
Summary of Study: Immunization of cynomolgus macaques with S coated onto lipid vesicles (S-LVs) induces high antibody titers with potent neutralizing activity against the vaccine strain, Alpha, Beta, and Gamma variants as well as T helper (Th)1 CD4+-biased T cell responses.
References: PMID: 35233549 / doi: 10.1016/j.xcrm.2022.100528
Contact Info: Winfried Weissenhorn: [email protected]; Roger Le Grand: [email protected]
URL: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00028-3?_retu…
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Institute de Biologie Structurale; Universite Paris-Saclay, Inserm, CEA; Amsterdam University Medical Centers; Institute Pasteur, Universite de Paris; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, vaccine candidate, synthetic spike (S) glycoprotein-coated lipid vesicles, immune response, primates
Summary of Study: Immunization of cynomolgus macaques with S coated onto lipid vesicles (S-LVs) induces high antibody titers with potent neutralizing activity against the vaccine strain, Alpha, Beta, and Gamma variants as well as T helper (Th)1 CD4+-biased T cell responses.
References: PMID: 35233549 / doi: 10.1016/j.xcrm.2022.100528
Contact Info: Winfried Weissenhorn: [email protected]; Roger Le Grand: [email protected]
URL: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00028-3?_retu…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; China National Center for Bioinformation; Capital Medical University; Chinese Academy of Medical Sciences and Peking Union Medical College; Huazhong University of Science & Technology
Keywords: SARS-CoV-2, transcriptomic profiling, virus replication, primates
Summary of Study: This study provides the transcriptome profiling of various tissues from the living primate host post SARS-CoV-2 infection. It illustrates that wide-spread transcriptomic changes involving diverse functions exist in multi-organs; an elevated immune response in cerebral cortex was the prominent feature at the early stage of SARS-CoV-2 infection.
References: PMID: 35377064 / doi: 10.1007/s13238-022-00915-5
Contact Info: Ying Yang: [email protected]; Yun-Gui Yang: [email protected]; Chuan Qin: [email protected]; Wei-Min Tong: [email protected]
URL: https://link.springer.com/article/10.1007/s13238-022-00915-5
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; China National Center for Bioinformation; Capital Medical University; Chinese Academy of Medical Sciences and Peking Union Medical College; Huazhong University of Science & Technology
Keywords: SARS-CoV-2, transcriptomic profiling, virus replication, primates
Summary of Study: This study provides the transcriptome profiling of various tissues from the living primate host post SARS-CoV-2 infection. It illustrates that wide-spread transcriptomic changes involving diverse functions exist in multi-organs; an elevated immune response in cerebral cortex was the prominent feature at the early stage of SARS-CoV-2 infection.
References: PMID: 35377064 / doi: 10.1007/s13238-022-00915-5
Contact Info: Ying Yang: [email protected]; Yun-Gui Yang: [email protected]; Chuan Qin: [email protected]; Wei-Min Tong: [email protected]
URL: https://link.springer.com/article/10.1007/s13238-022-00915-5
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Sanofi R&D; Universite de Strasbourg; Equipe 3Bio
Keywords: SARS-CoV-2, mRNA vaccine, lipid nanoparticles, stability, mice, primates
Summary of Study: The thermostability of mRNA/LNP is improved by a novel imidazole modified lipid, DOG-IM4, in combination with standard helper lipids.
References: PMID: 35576809 / doi: 10.1016/j.biomaterials.2022.121570
Contact Info: Jean Haensler: [email protected];
URL: https://www.sciencedirect.com/science/article/pii/S0142961222002101?via%3Dihub
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Sanofi R&D; Universite de Strasbourg; Equipe 3Bio
Keywords: SARS-CoV-2, mRNA vaccine, lipid nanoparticles, stability, mice, primates
Summary of Study: The thermostability of mRNA/LNP is improved by a novel imidazole modified lipid, DOG-IM4, in combination with standard helper lipids.
References: PMID: 35576809 / doi: 10.1016/j.biomaterials.2022.121570
Contact Info: Jean Haensler: [email protected];
URL: https://www.sciencedirect.com/science/article/pii/S0142961222002101?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Center for Genetic Engineering and Biotechnology, CIGB, Ave. 31 E/158 y 190, Havana 10600, Cuba
Keywords: SARS-CoV-2, chimeric antigen vaccine, immune response, mice, primates
Summary of Study: Fusion of SARS-CoV-2 receptor binding domain with the extracellular domain of human CD154 is a promising vaccine candidate
References: PMID: 35746505 PMCID: PMC9228316 DOI: 10.3390/vaccines10060897
Contact Info: Yamila Carpio and Mario Pablo Estrada: [email protected]; [email protected]
URL: https://www.mdpi.com/2076-393X/10/6/897
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Center for Genetic Engineering and Biotechnology, CIGB, Ave. 31 E/158 y 190, Havana 10600, Cuba
Keywords: SARS-CoV-2, chimeric antigen vaccine, immune response, mice, primates
Summary of Study: Fusion of SARS-CoV-2 receptor binding domain with the extracellular domain of human CD154 is a promising vaccine candidate
References: PMID: 35746505 PMCID: PMC9228316 DOI: 10.3390/vaccines10060897
Contact Info: Yamila Carpio and Mario Pablo Estrada: [email protected]; [email protected]
URL: https://www.mdpi.com/2076-393X/10/6/897
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Meissa Vaccines Inc; Bill & Melinda Gates Foundation; BIOQUAL Inc; Butler University; Vanderbilt University School of Medicine; University of Texas Medical Branch
Keywords: SARS-CoV-2, attenuated recombinant vaccine, immune response, primates
Summary of Study: A live, attenuated, recombinant human respiratory virus that expresses a chimeric SARS-CoV-2 spike protected against challenge and induced immunoglobulin and neutralizing antibodies.
References: PMID: 35906244 / doi: 10.1038/s41541-022-00509-6
Contact Info: Mariana F. Tioni: [email protected]
URL: https://www.nature.com/articles/s41541-022-00509-6
NHP Species: marmosets
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Meissa Vaccines Inc; Bill & Melinda Gates Foundation; BIOQUAL Inc; Butler University; Vanderbilt University School of Medicine; University of Texas Medical Branch
Keywords: SARS-CoV-2, attenuated recombinant vaccine, immune response, primates
Summary of Study: A live, attenuated, recombinant human respiratory virus that expresses a chimeric SARS-CoV-2 spike protected against challenge and induced immunoglobulin and neutralizing antibodies.
References: PMID: 35906244 / doi: 10.1038/s41541-022-00509-6
Contact Info: Mariana F. Tioni: [email protected]
URL: https://www.nature.com/articles/s41541-022-00509-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Veterinary and Animal Sciences, Pakistan
Keywords: SARS-CoV-2, iodine complexes, treatment, primates
Summary of Study: Iodine complexes have antiviral activity and help to clear coronavirus from monkeys, and Renessans with iodine complexes and ascorbic acid may provide an additive option for treatment.
References: PMID: 36143459; doi: 10.3390/life12091424
Contact Info: Tahir Yaqub: [email protected]
URL: https://www.mdpi.com/2075-1729/12/9/1424
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Veterinary and Animal Sciences, Pakistan
Keywords: SARS-CoV-2, iodine complexes, treatment, primates
Summary of Study: Iodine complexes have antiviral activity and help to clear coronavirus from monkeys, and Renessans with iodine complexes and ascorbic acid may provide an additive option for treatment.
References: PMID: 36143459; doi: 10.3390/life12091424
Contact Info: Tahir Yaqub: [email protected]
URL: https://www.mdpi.com/2075-1729/12/9/1424
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Chinese Academy of Sciences; State Key Laboratory of Respiratory Disease; Guangzhou Laboratory & Bioland Laboratory; Gangzhou nBiomed
Keywords: SARS-CoV-2, Ad5-vectored vaccine, SIV, immune response, primates
Summary of Study: Booster vaccination is required to elicit and maintain COVID-19 vaccine-induced immunity in SIV-infected macaques
References: doi: 10.1080/22221751.2022.2136538
Contact Info: Ling Chen: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2136538
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Chinese Academy of Sciences; State Key Laboratory of Respiratory Disease; Guangzhou Laboratory & Bioland Laboratory; Gangzhou nBiomed
Keywords: SARS-CoV-2, Ad5-vectored vaccine, SIV, immune response, primates
Summary of Study: Booster vaccination is required to elicit and maintain COVID-19 vaccine-induced immunity in SIV-infected macaques
References: doi: 10.1080/22221751.2022.2136538
Contact Info: Ling Chen: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2136538
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Beijing Institute for Brain Disorders, Capital Medical University, China; State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing , numerous others.
Keywords: SARS-CoV-2, single-nucleus transcriptomics, pathology, immune response, primates
Summary of Study: Single-nucleus transcriptomic profiling of multiple organs
References: doi: 10.24272/j.issn.2095-8137.2022.443
Contact Info: Xiaoqun Wang: nc.ude.unb@gnawnuqoaix
URL: https://www.zoores.ac.cn/en/article/doi/10.24272/j.issn.2095-8137.2022.443
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Beijing Institute for Brain Disorders, Capital Medical University, China; State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing , numerous others.
Keywords: SARS-CoV-2, single-nucleus transcriptomics, pathology, immune response, primates
Summary of Study: Single-nucleus transcriptomic profiling of multiple organs
References: doi: 10.24272/j.issn.2095-8137.2022.443
Contact Info: Xiaoqun Wang: nc.ude.unb@gnawnuqoaix
URL: https://www.zoores.ac.cn/en/article/doi/10.24272/j.issn.2095-8137.2022.443
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences; Fudan University; Shanghai King-Cell Biotechnology Co., Ltd.; Mabwell Bioscience Co., Ltd.; Shenzhen University; University of Chinese Academy of Sciences
Keywords: SARS-CoV-2, self-adjuvanting peptide vaccine, CoVac501, immune response, virus variants, primates
Summary of Study: CoVac501, a novel SARS-CoV-2 vaccine that is fully chemically synthesized and self-adjuvanting, provided potent protection for cynomolgus macaques against challenges from very high doses of SARS-CoV-2.
References: PMID: 35102138 / doi: 10.1038/s41421-021-00370-2
Contact Info: Qiuping Qin: [email protected]
URL: https://www.nature.com/articles/s41421-021-00370-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences; Fudan University; Shanghai King-Cell Biotechnology Co., Ltd.; Mabwell Bioscience Co., Ltd.; Shenzhen University; University of Chinese Academy of Sciences
Keywords: SARS-CoV-2, self-adjuvanting peptide vaccine, CoVac501, immune response, virus variants, primates
Summary of Study: CoVac501, a novel SARS-CoV-2 vaccine that is fully chemically synthesized and self-adjuvanting, provided potent protection for cynomolgus macaques against challenges from very high doses of SARS-CoV-2.
References: PMID: 35102138 / doi: 10.1038/s41421-021-00370-2
Contact Info: Qiuping Qin: [email protected]
URL: https://www.nature.com/articles/s41421-021-00370-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Pfizer; Icahn School of Medicine at Mount Sinai; Texas Biomedical Research Institute; New Iberia Research Center
Keywords: SARS-CoV-2, pathology, inflammation, Golden Syrian Hamster, primates
Summary of Study: Macaques may be appropriate for mechanistic studies of mild asymptomatic COVID-19 pneumonia and COVID-19-associated encephalitis, whereas Syrian hamsters may be more suited to study severe COVID-19 pneumonia.
References: PMID: 35128980 / doi: 10.1177/01926233211072767
Contact Info: Shambhunath Choudhary: [email protected]
URL: https://journals.sagepub.com/doi/full/10.1177/01926233211072767?rfr_dat=cr_pub+…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Pfizer; Icahn School of Medicine at Mount Sinai; Texas Biomedical Research Institute; New Iberia Research Center
Keywords: SARS-CoV-2, pathology, inflammation, Golden Syrian Hamster, primates
Summary of Study: Macaques may be appropriate for mechanistic studies of mild asymptomatic COVID-19 pneumonia and COVID-19-associated encephalitis, whereas Syrian hamsters may be more suited to study severe COVID-19 pneumonia.
References: PMID: 35128980 / doi: 10.1177/01926233211072767
Contact Info: Shambhunath Choudhary: [email protected]
URL: https://journals.sagepub.com/doi/full/10.1177/01926233211072767?rfr_dat=cr_pub+…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; Tongji Medical College of Huazhong University of Science & Technology
Keywords: SARS-CoV-2, infection, pathogenesis, virus variants, primates
Summary of Study: Delta variant of SARS-CoV-2 can effectively infect the Rhesus macaque.
References: PMID: 35279412 / doi: 10.1016/j.virs.2022.02.001
Contact Info: Zhiming Yuan: [email protected]; Chao Shan: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1995820X22000335?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; Tongji Medical College of Huazhong University of Science & Technology
Keywords: SARS-CoV-2, infection, pathogenesis, virus variants, primates
Summary of Study: Delta variant of SARS-CoV-2 can effectively infect the Rhesus macaque.
References: PMID: 35279412 / doi: 10.1016/j.virs.2022.02.001
Contact Info: Zhiming Yuan: [email protected]; Chao Shan: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1995820X22000335?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Fred Hutchinson Cancer Research Center; University of Washington; HDT Bio; NIAID; Washington National Primate Research Center
Keywords: SARS-CoV-2, phage-based deep mutational scanning, immune response, vaccination, primates
Summary of Study: Findings suggest that the antibody response to SARS-CoV-2 in macaques shares many features with humans, but with substantial differences in the recognition of certain epitopes and considerable individual variability in antibody escape profiles, suggesting a diverse repertoire of antibodies that can respond to major epitopes in both humans and macaques.
References: PMID: 35404959 / doi: 10.1371/journal.ppat.1010155
Contact Info: Julie Overbaugh: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010155
NHP Species: pigtail macaques, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Fred Hutchinson Cancer Research Center; University of Washington; HDT Bio; NIAID; Washington National Primate Research Center
Keywords: SARS-CoV-2, phage-based deep mutational scanning, immune response, vaccination, primates
Summary of Study: Findings suggest that the antibody response to SARS-CoV-2 in macaques shares many features with humans, but with substantial differences in the recognition of certain epitopes and considerable individual variability in antibody escape profiles, suggesting a diverse repertoire of antibodies that can respond to major epitopes in both humans and macaques.
References: PMID: 35404959 / doi: 10.1371/journal.ppat.1010155
Contact Info: Julie Overbaugh: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010155
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Institute Pasteur; Universite Paris Saclay-INSERM; Beth Israel Deaconess Medical Center
Keywords: SARS-CoV-2, NK cells, macrophages, blood and bronchoalveolar lavage, immune response, primates
Summary of Study: Viral antigen is found in alveolar macrophages up to at least 18 months after SARS-CoV-2 infection in macaques. Additionally, an association was revealed between lower level of persisting viral antigen in alveolar macrophages and the activity of Spike-specific adaptive NH cells in the lung.
References: PMID: 35547853 / doi: 12.21203/rs.3.rs-1561222/v1
Contact Info: Nicolas Huot: [email protected]
URL: https://www.researchsquare.com/article/rs-1561222/v1
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Institute Pasteur; Universite Paris Saclay-INSERM; Beth Israel Deaconess Medical Center
Keywords: SARS-CoV-2, NK cells, macrophages, blood and bronchoalveolar lavage, immune response, primates
Summary of Study: Viral antigen is found in alveolar macrophages up to at least 18 months after SARS-CoV-2 infection in macaques. Additionally, an association was revealed between lower level of persisting viral antigen in alveolar macrophages and the activity of Spike-specific adaptive NH cells in the lung.
References: PMID: 35547853 / doi: 12.21203/rs.3.rs-1561222/v1
Contact Info: Nicolas Huot: [email protected]
URL: https://www.researchsquare.com/article/rs-1561222/v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: National Rodent Laboratory Animal Resources Center; School of Basic Medical Sciences, Peking University Health Science Center; Northwest University; National Institutes for Food and Drug Control
Keywords: SARS-CoV-2, review, preclinical models, several animal species, primates
Summary of Study: Current animal models for COVID-19 have limitations, and novel models must be developed to truly evaluate the virulence of variants and comorbidities. Proposed model improvements include the use of transgenes or knock-ins to create multiple gene combinations, or reselecting receptor genes.
References: PMID: 35798699 / doi: 10.1038/s41392-022-01087-8
Contact Info: Youchun Wang: [email protected]
URL: https://www.nature.com/articles/s41392-022-01087-8
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: National Rodent Laboratory Animal Resources Center; School of Basic Medical Sciences, Peking University Health Science Center; Northwest University; National Institutes for Food and Drug Control
Keywords: SARS-CoV-2, review, preclinical models, several animal species, primates
Summary of Study: Current animal models for COVID-19 have limitations, and novel models must be developed to truly evaluate the virulence of variants and comorbidities. Proposed model improvements include the use of transgenes or knock-ins to create multiple gene combinations, or reselecting receptor genes.
References: PMID: 35798699 / doi: 10.1038/s41392-022-01087-8
Contact Info: Youchun Wang: [email protected]
URL: https://www.nature.com/articles/s41392-022-01087-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Saskatchewan; Dalhousie University; University of Pittsburgh
Keywords: SARS-CoV-2, review, post-acute sequelae, pathology, immune response, several animal species, primates
Summary of Study: Analysis of work done in different animal models in order to understand the mechanisms of Long COVID that could help identify treatments.
References: PMID: 36070309 / doi: 10.1371/journal.ppat.1010741
Contact Info: Alyson A. Kelvin: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010741
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Saskatchewan; Dalhousie University; University of Pittsburgh
Keywords: SARS-CoV-2, review, post-acute sequelae, pathology, immune response, several animal species, primates
Summary of Study: Analysis of work done in different animal models in order to understand the mechanisms of Long COVID that could help identify treatments.
References: PMID: 36070309 / doi: 10.1371/journal.ppat.1010741
Contact Info: Alyson A. Kelvin: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010741
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Oxford, UK; Ifakara Health Institute, Bagamoyo, Tanzania
Keywords: SARS-CoV-2, review, long-lived plasma cells, lymph node germinal centers, humans, primates
Summary of Study: Human lymphoid tissue sampling for vaccinology
References: doi: 10.3389/fimmu.2022.1045529
Contact Info: Carolyn M. Nielsen: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1045529/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Oxford, UK; Ifakara Health Institute, Bagamoyo, Tanzania
Keywords: SARS-CoV-2, review, long-lived plasma cells, lymph node germinal centers, humans, primates
Summary of Study: Human lymphoid tissue sampling for vaccinology
References: doi: 10.3389/fimmu.2022.1045529
Contact Info: Carolyn M. Nielsen: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1045529/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Emory University; University of Sao Paulo School of Medicine; Butantan Institute; La Jolla Institute for Immunology
Keywords: SARS-CoV-2, DNA vaccine HIVBr18, HLA class II vaccine epitopes, immunity, humans and primates
Summary of Study: Results provide preliminary proof of concept that immunization with a vaccine encoding epitopes with high and redundant coverage of the human population can elicit potent T cell responses to multiple epitopes, across species and MHC barriers.
References: PMID: 34961636 / doi: 10.1016/j.vaccine.2021.11.076
Contact Info: Edecio Cunha-Neto: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21015504?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Emory University; University of Sao Paulo School of Medicine; Butantan Institute; La Jolla Institute for Immunology
Keywords: SARS-CoV-2, DNA vaccine HIVBr18, HLA class II vaccine epitopes, immunity, humans and primates
Summary of Study: Results provide preliminary proof of concept that immunization with a vaccine encoding epitopes with high and redundant coverage of the human population can elicit potent T cell responses to multiple epitopes, across species and MHC barriers.
References: PMID: 34961636 / doi: 10.1016/j.vaccine.2021.11.076
Contact Info: Edecio Cunha-Neto: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21015504?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine; Nanchang University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, CRISPR-RT–PCR assay, longitudinal analysis, mucosal, plasma, and breath samples, primates
Summary of Study: CRISPR-FDS may provide a means to evaluate systemic viral/viral RNA burden not detectable by RT-qPCR to improve diagnosis and better predict outcomes for SARS-CoV-2 infections.
References: PMID: 35108153 / doi: 10.1080/22221751.2038020
Contact Info: Tony Hu: tonyhu2tulane.edu
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2038020
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine; Nanchang University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, CRISPR-RT–PCR assay, longitudinal analysis, mucosal, plasma, and breath samples, primates
Summary of Study: CRISPR-FDS may provide a means to evaluate systemic viral/viral RNA burden not detectable by RT-qPCR to improve diagnosis and better predict outcomes for SARS-CoV-2 infections.
References: PMID: 35108153 / doi: 10.1080/22221751.2038020
Contact Info: Tony Hu: tonyhu2tulane.edu
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2038020
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; University of California, Irvine
Keywords: SARS-CoV-2, Vesicular Stomatitis Virus-Based Vaccine, route of administration, immune response, primates
Summary of Study: The VSV-SARS2-EBOV vaccine presents a vaccine with a high potential as a boosting option after the already-approved mRNA-based vaccine, because VSV-SARS2-EBOV elicits primarily a humoral response, in contrast to the predominantly T cell-driven immune response after mRNA vaccination.
References: PMID: 35012339 / doi: 10.1128/mbio.03379-21
Contact Info: Andrea Marzi: [email protected]
URL: https://journals.asm.org/doi/full/10.1128/mbio.03379-21?rfr_dat=cr_pub++0pubmed…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; University of California, Irvine
Keywords: SARS-CoV-2, Vesicular Stomatitis Virus-Based Vaccine, route of administration, immune response, primates
Summary of Study: The VSV-SARS2-EBOV vaccine presents a vaccine with a high potential as a boosting option after the already-approved mRNA-based vaccine, because VSV-SARS2-EBOV elicits primarily a humoral response, in contrast to the predominantly T cell-driven immune response after mRNA vaccination.
References: PMID: 35012339 / doi: 10.1128/mbio.03379-21
Contact Info: Andrea Marzi: [email protected]
URL: https://journals.asm.org/doi/full/10.1128/mbio.03379-21?rfr_dat=cr_pub++0pubmed…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Institute of Infectious Diseases, Tokyo; Kumamoto University; ID Pharma Co., Ltd.
Keywords: SARS-CoV-2, intranasal vaccine, non-S antigens, immune response, primates
Summary of Study: CD8+ T cell induction by intranasal vaccination with a vaccine expressing viral non-S antigens can result in NAb-independent control of SARS-CoV-2 infection.
References: PMID: 35233545 / doi: 10.1016/j.xcrm.2022.100520
Contact Info: Tetsuro Matano: [email protected]
URL: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00020-9?_retu…
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Institute of Infectious Diseases, Tokyo; Kumamoto University; ID Pharma Co., Ltd.
Keywords: SARS-CoV-2, intranasal vaccine, non-S antigens, immune response, primates
Summary of Study: CD8+ T cell induction by intranasal vaccination with a vaccine expressing viral non-S antigens can result in NAb-independent control of SARS-CoV-2 infection.
References: PMID: 35233545 / doi: 10.1016/j.xcrm.2022.100520
Contact Info: Tetsuro Matano: [email protected]
URL: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00020-9?_retu…
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Illinois College of Medicine
Keywords: SARS-CoV-2, transcriptomic profiling, lung endothelial cells, primates
Summary of Study: The specific genes that distinguished immuneEC and devEC populations in the NHP lungs after SARS-CoV-2 infection were different from the endotoxemic mouse lung. This may reflect either species differences or different injury-specific responses (bacterial endotoxin vs. SARS-CoV-2).
References: PMID: 35511435 / doi: 10.1172/jci.insight.158079
Contact Info: Lianghui Zhang: [email protected]; Jalees Rehman: [email protected]
URL: https://insight.jci.org/articles/view/158079
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Illinois College of Medicine
Keywords: SARS-CoV-2, transcriptomic profiling, lung endothelial cells, primates
Summary of Study: The specific genes that distinguished immuneEC and devEC populations in the NHP lungs after SARS-CoV-2 infection were different from the endotoxemic mouse lung. This may reflect either species differences or different injury-specific responses (bacterial endotoxin vs. SARS-CoV-2).
References: PMID: 35511435 / doi: 10.1172/jci.insight.158079
Contact Info: Lianghui Zhang: [email protected]; Jalees Rehman: [email protected]
URL: https://insight.jci.org/articles/view/158079
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Fred Hutchinson Cancer Research Center; Department of Medicine, University of Washington
Keywords: SARS-CoV-2, remdesivir, math modeling, antiviral potency, nasal passages, lungs, primates
Summary of Study: In rhesus macaques, the nonlinear forces governing SARS-CoV-2 viral load trajectories in the lung and nasal passages differ substantially in the presence of a partially effective antiviral therapy. To the extent that the rhesus macaque model approximates human infection, nasal viral load remains a promising surrogate endpoint marker but perhaps only in the context of a highly potent antiviral therapy.
References: PMID: 35634576 / doi: 10.1016/j.isci.2022.104448
Contact Info: Joshua Schiffer: [email protected]
URL: https://www.cell.com/iscience/fulltext/S2589-0042(22)00719-2?_returnURL=https%3…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Fred Hutchinson Cancer Research Center; Department of Medicine, University of Washington
Keywords: SARS-CoV-2, remdesivir, math modeling, antiviral potency, nasal passages, lungs, primates
Summary of Study: In rhesus macaques, the nonlinear forces governing SARS-CoV-2 viral load trajectories in the lung and nasal passages differ substantially in the presence of a partially effective antiviral therapy. To the extent that the rhesus macaque model approximates human infection, nasal viral load remains a promising surrogate endpoint marker but perhaps only in the context of a highly potent antiviral therapy.
References: PMID: 35634576 / doi: 10.1016/j.isci.2022.104448
Contact Info: Joshua Schiffer: [email protected]
URL: https://www.cell.com/iscience/fulltext/S2589-0042(22)00719-2?_returnURL=https%3…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Université Paris-Saclay; Assistance Publique-Hôpitaux de Paris; Obesity Center, Department of Digestive, Oncologic and Metabolic Surgery, Institut Mutualiste Montsouris, Paris
Keywords: SARS-CoV-2, fat tissue, diagnostics, immunity, primates
Summary of Study: Subcutaneous adipose tissue (SCAT) is selectively infected by SARS-CoV-2 although changes in the immune properties of adispose tissue are observed in both SCAT and visceral adipose tissue
References: PMID: 35661814 PMCID: PMC9166782 DOI: 10.1038/s42003-022-03503-9
Contact Info: Christine Bourgeois: [email protected]
URL: https://www.nature.com/articles/s42003-022-03503-9
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Université Paris-Saclay; Assistance Publique-Hôpitaux de Paris; Obesity Center, Department of Digestive, Oncologic and Metabolic Surgery, Institut Mutualiste Montsouris, Paris
Keywords: SARS-CoV-2, fat tissue, diagnostics, immunity, primates
Summary of Study: Subcutaneous adipose tissue (SCAT) is selectively infected by SARS-CoV-2 although changes in the immune properties of adispose tissue are observed in both SCAT and visceral adipose tissue
References: PMID: 35661814 PMCID: PMC9166782 DOI: 10.1038/s42003-022-03503-9
Contact Info: Christine Bourgeois: [email protected]
URL: https://www.nature.com/articles/s42003-022-03503-9
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA; numerous others
Keywords: SARS-CoV-2, vaccine, Ad26.COV2.S, spike ferritin nanoparticles, immune response, primates
Summary of Study: Protection against SARS-CoV-2 Omicron BA.1 variant challenge
References: doi: 10.1126/sciadv.ade4433
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.ade4433
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA; numerous others
Keywords: SARS-CoV-2, vaccine, Ad26.COV2.S, spike ferritin nanoparticles, immune response, primates
Summary of Study: Protection against SARS-CoV-2 Omicron BA.1 variant challenge
References: doi: 10.1126/sciadv.ade4433
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.ade4433
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; Gilead Sciences
Keywords: SARS-CoV-2, Remdesivir, subcutaneous administration, pathology, virus load, primates
Summary of Study: Early subcutaneous administration of remdesivir can protect from lower respiratory tract disease caused by SARS-CoV-2.
References: PMID: 35032523 / doi: 10.1016/j.antiviral.2022.105246
Contact Info: Emmie de Wit: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0166354222000146?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; Gilead Sciences
Keywords: SARS-CoV-2, Remdesivir, subcutaneous administration, pathology, virus load, primates
Summary of Study: Early subcutaneous administration of remdesivir can protect from lower respiratory tract disease caused by SARS-CoV-2.
References: PMID: 35032523 / doi: 10.1016/j.antiviral.2022.105246
Contact Info: Emmie de Wit: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0166354222000146?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Janssen Vaccines and Prevention; Ragon Institute of MGH, MIT and Harvard; BIOQUAL; Amsterdam University Medical Center
Keywords: SARS-CoV-2, homologous or variant booster vaccine, humoral and cellular immune responses, primates
Summary of Study: A late boost with Ad26.COV2.S or Ad26.COV2.S.351 resulted in a marked increase in humoral and cellular immune responses that were highly cross-reactive across multiple SARS-CoV-2 variants in rhesus macaques.
References: PMID: 35191769 / doi: 10.1126/scitranslmed.bm4996
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abm4996?rfr_dat=cr_pub++0…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Janssen Vaccines and Prevention; Ragon Institute of MGH, MIT and Harvard; BIOQUAL; Amsterdam University Medical Center
Keywords: SARS-CoV-2, homologous or variant booster vaccine, humoral and cellular immune responses, primates
Summary of Study: A late boost with Ad26.COV2.S or Ad26.COV2.S.351 resulted in a marked increase in humoral and cellular immune responses that were highly cross-reactive across multiple SARS-CoV-2 variants in rhesus macaques.
References: PMID: 35191769 / doi: 10.1126/scitranslmed.bm4996
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abm4996?rfr_dat=cr_pub++0…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre; Department of Pathology, Amsterdam UMC; Utrecht University; Leiden University Medical Center; University of Twente
Keywords: SARS-CoV-2, neuropathology, immune response, primates
Summary of Study: Data highlight the potential of SARS-CoV-2 to cause pathology in the brain of macaques. A range of neurological abnormalities were observed, including hypermetabolic pituitary gland, alpha-synuclein inclusions, activated microglia in the brain parenchyma, and infiltrating T-cells.
References: PMID: 35458506 / doi: 10.3390/v14040776
Contact Info: Ernst Verschoor: [email protected]
URL: https://www.mdpi.com/1999-4915/14/4/776
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre; Department of Pathology, Amsterdam UMC; Utrecht University; Leiden University Medical Center; University of Twente
Keywords: SARS-CoV-2, neuropathology, immune response, primates
Summary of Study: Data highlight the potential of SARS-CoV-2 to cause pathology in the brain of macaques. A range of neurological abnormalities were observed, including hypermetabolic pituitary gland, alpha-synuclein inclusions, activated microglia in the brain parenchyma, and infiltrating T-cells.
References: PMID: 35458506 / doi: 10.3390/v14040776
Contact Info: Ernst Verschoor: [email protected]
URL: https://www.mdpi.com/1999-4915/14/4/776
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, protocols, animal models, immunology, primates
Summary of Study: This book describes the different aspects of modelling the SARS-CoV-2 infection in NHPs along with the associated methods used in immunology.
References: PMID: 35554911 / doi. 10.1007/978-1-2111-0_15
Contact Info: Deepak Kaushal: [email protected]
URL: https://link.springer.com/protocol/10.1007/978-1-0716-2111-0_15
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, protocols, animal models, immunology, primates
Summary of Study: This book describes the different aspects of modelling the SARS-CoV-2 infection in NHPs along with the associated methods used in immunology.
References: PMID: 35554911 / doi. 10.1007/978-1-2111-0_15
Contact Info: Deepak Kaushal: [email protected]
URL: https://link.springer.com/protocol/10.1007/978-1-0716-2111-0_15
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Institute of Zoonosis, and College of Veterinary Medicine, Jilin University; Chinese Academy of Medicine Sciences & Peking Union Medical College; Walvax Biotechnology Co., Ltd; Inner Mongolia University for Nationalities; Chinese Academy of Agricultural Sciences; Yuxi JOZO Biotechnology co., LTD; Tongji Medical College, Huazhong University of Science and Technology
Keywords: SARS-CoV-2, equine immunoglobulin, anti virus efficacy, histopathology, immune response, primates
Summary of Study: Therapeutic-grade equine immunoglobins are effective at improving the clinical symptoms of those hospitalized with SARS-CoV-2 and can be rapidly developed.
References: PMID: 35798694 / doi: 10.1038/s41392-022-01095-8
Contact Info: Zhongping Xie: [email protected]; Ningyi Jin: [email protected]; Mingyuan Liu: [email protected]
URL: https://www.nature.com/articles/s41392-022-01095-8
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Institute of Zoonosis, and College of Veterinary Medicine, Jilin University; Chinese Academy of Medicine Sciences & Peking Union Medical College; Walvax Biotechnology Co., Ltd; Inner Mongolia University for Nationalities; Chinese Academy of Agricultural Sciences; Yuxi JOZO Biotechnology co., LTD; Tongji Medical College, Huazhong University of Science and Technology
Keywords: SARS-CoV-2, equine immunoglobulin, anti virus efficacy, histopathology, immune response, primates
Summary of Study: Therapeutic-grade equine immunoglobins are effective at improving the clinical symptoms of those hospitalized with SARS-CoV-2 and can be rapidly developed.
References: PMID: 35798694 / doi: 10.1038/s41392-022-01095-8
Contact Info: Zhongping Xie: [email protected]; Ningyi Jin: [email protected]; Mingyuan Liu: [email protected]
URL: https://www.nature.com/articles/s41392-022-01095-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences & Peking Union Medical College; Kunming No.1 High School; Kunming National High-level Biosafety Primate Research Center
Keywords: SARS-CoV-2, vaccines, repertoire diversities of B cells and T cells, whole-virus inactivated and S1 protein subunit vaccine, primates
Summary of Study: Comparison of B-cell and T-cell responses between a whole-virus inactivated vaccine and an S1 protein subunit vaccine.
References: PMID: 36070519 / doi: 10.1080/21645515.2022.2118477
Contact Info: Huiwen Zheng: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/21645515.2022.2118477
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences & Peking Union Medical College; Kunming No.1 High School; Kunming National High-level Biosafety Primate Research Center
Keywords: SARS-CoV-2, vaccines, repertoire diversities of B cells and T cells, whole-virus inactivated and S1 protein subunit vaccine, primates
Summary of Study: Comparison of B-cell and T-cell responses between a whole-virus inactivated vaccine and an S1 protein subunit vaccine.
References: PMID: 36070519 / doi: 10.1080/21645515.2022.2118477
Contact Info: Huiwen Zheng: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/21645515.2022.2118477
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Shiga University of Medical Science, Otsu, Japan; others
Keywords: SARS-CoV-2, vaccine development, attenuated vaccinia virus, immune response, proteomics, virus variants, mice, primates
Summary of Study: Vaccine protects monkeys and transgenic mice from SARS-CoV-2 and variants
References: doi: 10.3389/fmicb.2022.967019
Contact Info: Michinori Kohara: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2022.967019/full
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Shiga University of Medical Science, Otsu, Japan; others
Keywords: SARS-CoV-2, vaccine development, attenuated vaccinia virus, immune response, proteomics, virus variants, mice, primates
Summary of Study: Vaccine protects monkeys and transgenic mice from SARS-CoV-2 and variants
References: doi: 10.3389/fmicb.2022.967019
Contact Info: Michinori Kohara: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2022.967019/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; Yerkes National Primate Research Center; Emory University School of Medicine; Bioqual; Moderna, Inc.
Keywords: SARS-CoV-2, mRNA-1273 vaccination, longitudinal study, immune response, primates
Summary of Study: While mRNA-1273 provided durable protection against B.1.617.2 challenge, control of the virus was briefly delayed in the lungs and limited in the nose, which may provide the virus with a greater opportunity for transmission.
References: PMID: 34921774 / doi: 10.1016/j.cell.2021.12.002
Contact Info: Robert Seder: [email protected]; Daniel Douek: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0092867421014057?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; Yerkes National Primate Research Center; Emory University School of Medicine; Bioqual; Moderna, Inc.
Keywords: SARS-CoV-2, mRNA-1273 vaccination, longitudinal study, immune response, primates
Summary of Study: While mRNA-1273 provided durable protection against B.1.617.2 challenge, control of the virus was briefly delayed in the lungs and limited in the nose, which may provide the virus with a greater opportunity for transmission.
References: PMID: 34921774 / doi: 10.1016/j.cell.2021.12.002
Contact Info: Robert Seder: [email protected]; Daniel Douek: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0092867421014057?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medicine Sciences & Peking Union Medical College; National Institute for Viral Disease Control and Prevention
Keywords: SARS-CoV-2, heterologous vaccines, intradermal administration, immune response, primates
Summary of Study: This study reports a new heterologous prime-boost strategy of intradermal immunization with the inactivated vaccine and K-S antigen. This strategy can significantly increase the neutralizing antibody titers and promote specific T cell responses in mice and macaques.
References: PMID: 34931939 / doi: 10.1080/22221751.2021807https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
Contact Info: Wenbo Xu: [email protected]; Qihan Li: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medicine Sciences & Peking Union Medical College; National Institute for Viral Disease Control and Prevention
Keywords: SARS-CoV-2, heterologous vaccines, intradermal administration, immune response, primates
Summary of Study: This study reports a new heterologous prime-boost strategy of intradermal immunization with the inactivated vaccine and K-S antigen. This strategy can significantly increase the neutralizing antibody titers and promote specific T cell responses in mice and macaques.
References: PMID: 34931939 / doi: 10.1080/22221751.2021807https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
Contact Info: Wenbo Xu: [email protected]; Qihan Li: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine
Keywords: SARS-CoV-2, virus genome, gut, virus evolution, primates
Summary of Study: Previous reports that an intact furin cleavage site is important for infection in vivo were confirmed in this study. Additionally, three mutations were identified that may represent an adaptation of SARS-CoV2 to African green monkeys or to NHP generally.
References: PMID: 35062281 / doi: 10.3390/v14010077
Contact Info: Nicholas Maness: [email protected]
URL: https://www.mdpi.com/1999-4915/14/1/77
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine
Keywords: SARS-CoV-2, virus genome, gut, virus evolution, primates
Summary of Study: Previous reports that an intact furin cleavage site is important for infection in vivo were confirmed in this study. Additionally, three mutations were identified that may represent an adaptation of SARS-CoV2 to African green monkeys or to NHP generally.
References: PMID: 35062281 / doi: 10.3390/v14010077
Contact Info: Nicholas Maness: [email protected]
URL: https://www.mdpi.com/1999-4915/14/1/77
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Shanghai Jiao Tong University; Westlake University, Hangzhou; University of Texas; Jecho Biopharmaceuticals; Jecho Laboratories; Zhengzhou University People's Hospital
Keywords: SARS-CoV-2, virus variants, neutralizing monoclonal antibodies, immune response, mice, primates
Summary of Study: An antibody designated as 2G1 efficiently neutralized all VOCs including widely spread Alpha, Beta, Gamma, Delta variants and Cluster 5, a variant with Y453F substitution that once caused public concern due to its zoonotic characteristics.
References: PMID: 35169121 / doi: 10.1038/s41421-022-00381-7
Contact Info: Lei Han: [email protected]
URL: https://www.nature.com/articles/s41421-022-00381-7
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Shanghai Jiao Tong University; Westlake University, Hangzhou; University of Texas; Jecho Biopharmaceuticals; Jecho Laboratories; Zhengzhou University People's Hospital
Keywords: SARS-CoV-2, virus variants, neutralizing monoclonal antibodies, immune response, mice, primates
Summary of Study: An antibody designated as 2G1 efficiently neutralized all VOCs including widely spread Alpha, Beta, Gamma, Delta variants and Cluster 5, a variant with Y453F substitution that once caused public concern due to its zoonotic characteristics.
References: PMID: 35169121 / doi: 10.1038/s41421-022-00381-7
Contact Info: Lei Han: [email protected]
URL: https://www.nature.com/articles/s41421-022-00381-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Peking University; Chinese Academy of Medical Sciences and Peking Union Medical College; WHO Collaborating Center for Standardization and Evaluation of Biologicals
Keywords: SARS-CoV-2, circRNA vaccine, neutralizing antibodies, virus variants, primates
Summary of Study: CircRNA/RBD-Omicron vaccine induced effective neutralizing antibodies against the Omicron but not the Delta variant. In contrast, the circRNA/RBD-Delta vaccine protected against both Delta and Omicron or functioned as a booster after two doses of either native- or Delta-specific vaccination, making it a favorable choice against the current variants of concern of SARS-CoV-2.
References: PMID: 35460644 / doi: 10.1016/j.cell.2022.03.044
Contact Info: Wensheng Wei: [email protected]
URL: https://www.cell.com/cell/fulltext/S0092-8674(22)00394-4?_returnURL=https%3A%2F…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Peking University; Chinese Academy of Medical Sciences and Peking Union Medical College; WHO Collaborating Center for Standardization and Evaluation of Biologicals
Keywords: SARS-CoV-2, circRNA vaccine, neutralizing antibodies, virus variants, primates
Summary of Study: CircRNA/RBD-Omicron vaccine induced effective neutralizing antibodies against the Omicron but not the Delta variant. In contrast, the circRNA/RBD-Delta vaccine protected against both Delta and Omicron or functioned as a booster after two doses of either native- or Delta-specific vaccination, making it a favorable choice against the current variants of concern of SARS-CoV-2.
References: PMID: 35460644 / doi: 10.1016/j.cell.2022.03.044
Contact Info: Wensheng Wei: [email protected]
URL: https://www.cell.com/cell/fulltext/S0092-8674(22)00394-4?_returnURL=https%3A%2F…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: SUNY Upstate Medical University; Walter Reed Army Institute of Research; NIAID
Keywords: SARS-CoV-2, mRNA-1273 vaccine, respiratory tract, inflammation, primates
Summary of Study: This study defines the lower respiratory tract cellular and transcriptional signature associated with SARS-CoV-2 in macaques using two distinct viral variants, and identifies conserved signatures of vaccine-elicited protection from infection-attendant inflammation. These date emphasize the contribution of inflammatory/migratory DCs and macrophages to lower respiratory tract inflammation following SARS-CoV-2 infection, and define a critical relationship between antibody titers, post-challenge viral burden, and broad infection-elicited inflammation.
References: PMID: 35653196 / doi: 10.1172/jci.insight.160039
Contact Info: Robert Seder: Robert Seder: [email protected]
URL: https://insight.jci.org/articles/view/160039
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: SUNY Upstate Medical University; Walter Reed Army Institute of Research; NIAID
Keywords: SARS-CoV-2, mRNA-1273 vaccine, respiratory tract, inflammation, primates
Summary of Study: This study defines the lower respiratory tract cellular and transcriptional signature associated with SARS-CoV-2 in macaques using two distinct viral variants, and identifies conserved signatures of vaccine-elicited protection from infection-attendant inflammation. These date emphasize the contribution of inflammatory/migratory DCs and macrophages to lower respiratory tract inflammation following SARS-CoV-2 infection, and define a critical relationship between antibody titers, post-challenge viral burden, and broad infection-elicited inflammation.
References: PMID: 35653196 / doi: 10.1172/jci.insight.160039
Contact Info: Robert Seder: Robert Seder: [email protected]
URL: https://insight.jci.org/articles/view/160039