Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: The First Affiliated Hospital of Jinan University, Guangzhou 510630, China; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA USA
Keywords: SARS-CoV-2, favipiravir, biodistribution and pharmacokinetics, positron emission tomography, mice, primates
Summary of Study: Evaluating Favipiravir in rodents and nonhuman primates (NHP) with positron emission tomography
References: PMID: 37111280 / doi: 10.3390/ph16040524
Contact Info: Steven Liang: steven.liang@emory.edu
URL: https://www.mdpi.com/1424-8247/16/4/524
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: The First Affiliated Hospital of Jinan University, Guangzhou 510630, China; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA USA
Keywords: SARS-CoV-2, favipiravir, biodistribution and pharmacokinetics, positron emission tomography, mice, primates
Summary of Study: Evaluating Favipiravir in rodents and nonhuman primates (NHP) with positron emission tomography
References: PMID: 37111280 / doi: 10.3390/ph16040524
Contact Info: Steven Liang: steven.liang@emory.edu
URL: https://www.mdpi.com/1424-8247/16/4/524
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Virology and Immunology, Graduate School of Medicine, Osaka University, Osaka, 565-0871 Japan, others
Keywords: SARS-CoV-2, vaccine, Spike (S) receptor binding domain, immune response, primates
Summary of Study: saRNA vaccine expressing membrane-anchored RBD elicits broad and durable immunity
References: doi: 10.1038/s41467-023-38457-x
Contact Info: Takuya Yamamoto: yamamotot2@nibiohn.go.jp
URL: https://www.nature.com/articles/s41467-023-38457-x
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Virology and Immunology, Graduate School of Medicine, Osaka University, Osaka, 565-0871 Japan, others
Keywords: SARS-CoV-2, vaccine, Spike (S) receptor binding domain, immune response, primates
Summary of Study: saRNA vaccine expressing membrane-anchored RBD elicits broad and durable immunity
References: doi: 10.1038/s41467-023-38457-x
Contact Info: Takuya Yamamoto: yamamotot2@nibiohn.go.jp
URL: https://www.nature.com/articles/s41467-023-38457-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review: animal models
NPRC/Institute: Department de Sanitat i Anatomia Animals, Facultat de Veterinària, Campus de la UAB, Bellaterra, Spain; Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.; others
Keywords: SARS-CoV-2, review, animal models, neurological and neuropsychiatric symptoms, several species, primates
Summary of Study: Animal models to study neurological manifestations
References: DOI: 10.1038/s41684-023-01231-z
Contact Info: Joaquim Segalés: joaquim.segales@irta.cat
URL: https://www.nature.com/articles/s41684-023-01231-z
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review: animal models
NPRC/Institute: Department de Sanitat i Anatomia Animals, Facultat de Veterinària, Campus de la UAB, Bellaterra, Spain; Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.; others
Keywords: SARS-CoV-2, review, animal models, neurological and neuropsychiatric symptoms, several species, primates
Summary of Study: Animal models to study neurological manifestations
References: DOI: 10.1038/s41684-023-01231-z
Contact Info: Joaquim Segalés: joaquim.segales@irta.cat
URL: https://www.nature.com/articles/s41684-023-01231-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microbes and Infection, Fudan University, Shanghai, China
Keywords: SARS-CoV-2, fusion inhibitor, IgG-binding peptide, immune response, primates
Summary of Study: IgG Fc-Binding Peptide-Conjugated Pan-CoV Fusion Inhibitor Combined with Neutralizing Antibodies
References: DOI: 10.3390/biom13091283
Contact Info: Shibo Jiang:shibojiang@fudan.edu.cn; Shuai Xia: sxia15@fudan.edu.cn
URL: https://www.mdpi.com/2218-273X/13/9/1283
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microbes and Infection, Fudan University, Shanghai, China
Keywords: SARS-CoV-2, fusion inhibitor, IgG-binding peptide, immune response, primates
Summary of Study: IgG Fc-Binding Peptide-Conjugated Pan-CoV Fusion Inhibitor Combined with Neutralizing Antibodies
References: DOI: 10.3390/biom13091283
Contact Info: Shibo Jiang:shibojiang@fudan.edu.cn; Shuai Xia: sxia15@fudan.edu.cn
URL: https://www.mdpi.com/2218-273X/13/9/1283
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Wayne State University, Detroit, Michigan, Center for Comparative Medicine, Massachusetts General Hospital, Boston, Massachusetts, Division of Animal Resources, University of Illinois at Urbana-Champaign, Champaign, Illinois
Keywords: SARS-CoV-2, review, neurological symptoms, humans, mice, hamsters, ferrets, primates
Summary of Study: Animal Models for the Study of Neurologic Manifestations Of COVID-19
References: doi: 10.30802/AALAS-CM-22-000073
Contact Info: Kelsey Carpenter: kelsey.carpenter2@wayne.edu
URL: https://www.ingentaconnect.com/content/aalas/cm/2023/00000073/00000001/art00006
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Wayne State University, Detroit, Michigan, Center for Comparative Medicine, Massachusetts General Hospital, Boston, Massachusetts, Division of Animal Resources, University of Illinois at Urbana-Champaign, Champaign, Illinois
Keywords: SARS-CoV-2, review, neurological symptoms, humans, mice, hamsters, ferrets, primates
Summary of Study: Animal Models for the Study of Neurologic Manifestations Of COVID-19
References: doi: 10.30802/AALAS-CM-22-000073
Contact Info: Kelsey Carpenter: kelsey.carpenter2@wayne.edu
URL: https://www.ingentaconnect.com/content/aalas/cm/2023/00000073/00000001/art00006
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Massachusetts General Hospital, Charlestown, Massachusetts USA; Brigham and Women's Hospital, Boston, Massachusetts, and others
Keywords: SARS-CoV-2, review, brain autopsies, neuropathological findings, humans, animal models, primates
Summary of Study: Review: What Can We Still Learn from Brain Autopsies in COVID-19?
References: PMID: 37023787 / doi: 10.1055/s-0043-1767716
Contact Info: Shibani Mukerji: smukerji@partners.org
URL: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-17677…
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Massachusetts General Hospital, Charlestown, Massachusetts USA; Brigham and Women's Hospital, Boston, Massachusetts, and others
Keywords: SARS-CoV-2, review, brain autopsies, neuropathological findings, humans, animal models, primates
Summary of Study: Review: What Can We Still Learn from Brain Autopsies in COVID-19?
References: PMID: 37023787 / doi: 10.1055/s-0043-1767716
Contact Info: Shibani Mukerji: smukerji@partners.org
URL: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-17677…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, 200438, China., many others
Keywords: SARS-CoV-2, vaccine, mRNA-based T-cell-inducing antigen, immune response, primates
Summary of Study: mRNA-based T-cell-inducing antigen strengthens COVID-19 vaccine
References: doi: 10.1038/s41467-023-38751-8
Contact Info: Jinzhong Lin: linjinzhong@fudan.edu.cn
URL: https://www.nature.com/articles/s41467-023-38751-8
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, 200438, China., many others
Keywords: SARS-CoV-2, vaccine, mRNA-based T-cell-inducing antigen, immune response, primates
Summary of Study: mRNA-based T-cell-inducing antigen strengthens COVID-19 vaccine
References: doi: 10.1038/s41467-023-38751-8
Contact Info: Jinzhong Lin: linjinzhong@fudan.edu.cn
URL: https://www.nature.com/articles/s41467-023-38751-8
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: inhaled protectant
NPRC/Institute: Graduate School of Medicine and Veterinary Medicine, University of Miyazaki, Miyazaki, 889-2155, Japan; Laboratory of Immunoregulation and Vaccine Research, Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Tsukuba, 305-0843, Japan.; others
Keywords: SARS-CoV-2, ACE2 decoy, immune response, pathology, mice, hamsters, primates
Summary of Study: Inhaled ACE2 decoy confers protection
References: DOI: 10.1126/scitranslmed.adi2623
Contact Info: Atsushi Hoshino: a-hoshi@koto.kpu-m.ac.jp
URL: https://www.science.org/doi/10.1126/scitranslmed.adi2623
NHP Species:
Year Published: 2023
Study Type/Review: inhaled protectant
NPRC/Institute: Graduate School of Medicine and Veterinary Medicine, University of Miyazaki, Miyazaki, 889-2155, Japan; Laboratory of Immunoregulation and Vaccine Research, Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Tsukuba, 305-0843, Japan.; others
Keywords: SARS-CoV-2, ACE2 decoy, immune response, pathology, mice, hamsters, primates
Summary of Study: Inhaled ACE2 decoy confers protection
References: DOI: 10.1126/scitranslmed.adi2623
Contact Info: Atsushi Hoshino: a-hoshi@koto.kpu-m.ac.jp
URL: https://www.science.org/doi/10.1126/scitranslmed.adi2623
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Executive Office, Shanghai BravoBio Co., Ltd., Shanghai, China; BravoVax Co., Ltd., Wuhan, China
Keywords: SARS-CoV-2, adenovirus vaccine, aerosol inhalation, immune response, primates
Summary of Study: Aerosol Inhalation of Chimpanzee Adenovirus Vectors (ChAd68) Expressing Ancestral or Omicron BA.1 Stabilized Pre-Fusion Spike Glycoproteins
References: DOI: 10.3390/vaccines11091427
Contact Info: Ke Wu: ke.wu@bravovax.com
URL: https://www.mdpi.com/2076-393X/11/9/1427
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Executive Office, Shanghai BravoBio Co., Ltd., Shanghai, China; BravoVax Co., Ltd., Wuhan, China
Keywords: SARS-CoV-2, adenovirus vaccine, aerosol inhalation, immune response, primates
Summary of Study: Aerosol Inhalation of Chimpanzee Adenovirus Vectors (ChAd68) Expressing Ancestral or Omicron BA.1 Stabilized Pre-Fusion Spike Glycoproteins
References: DOI: 10.3390/vaccines11091427
Contact Info: Ke Wu: ke.wu@bravovax.com
URL: https://www.mdpi.com/2076-393X/11/9/1427
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Tulane NPRC; Duke University Medical Center
Keywords: SARS-CoV-2, prophylactic administration, convalescent plasma, disease progression and severity, primates
Summary of Study: Convalescent plasma administration results in suboptimal prophylaxis against SARS-CoV-2 infection
References: doi: 10.3389/fimmu.2023.1085883
Contact Info: Chad Roy: croy@tulane.edu
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1085883/full
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Tulane NPRC; Duke University Medical Center
Keywords: SARS-CoV-2, prophylactic administration, convalescent plasma, disease progression and severity, primates
Summary of Study: Convalescent plasma administration results in suboptimal prophylaxis against SARS-CoV-2 infection
References: doi: 10.3389/fimmu.2023.1085883
Contact Info: Chad Roy: croy@tulane.edu
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1085883/full