Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: California Institute of Technology; NIAID, Fred Hutchinson Cancer Research Center; Bioqual; University of Oxford; Howard Hughes Medical Institute
Keywords: SARS-CoV-2, spike receptor-binding domains, mosaic nanoparticles, immunogenicity, mice, primates
Summary of Study: A mosaic RBD nanoparticle presenting 8 different sarbecovirus RBDs protected against challenges from both matched and mismatched sarbecoviruses, as compared with homotypic SARS-2 RBD nanoparticles that protected fully only against a matched challenge.
References: PMID: 35378752 / doi: 10.1101/2022.03.25.485875
Contact Info: Pamela Bjorkman: bjorkman@caltech.edu
URL: https://www.biorxiv.org/content/10.1101/2022.03.25.485875v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: California Institute of Technology; NIAID, Fred Hutchinson Cancer Research Center; Bioqual; University of Oxford; Howard Hughes Medical Institute
Keywords: SARS-CoV-2, spike receptor-binding domains, mosaic nanoparticles, immunogenicity, mice, primates
Summary of Study: A mosaic RBD nanoparticle presenting 8 different sarbecovirus RBDs protected against challenges from both matched and mismatched sarbecoviruses, as compared with homotypic SARS-2 RBD nanoparticles that protected fully only against a matched challenge.
References: PMID: 35378752 / doi: 10.1101/2022.03.25.485875
Contact Info: Pamela Bjorkman: bjorkman@caltech.edu
URL: https://www.biorxiv.org/content/10.1101/2022.03.25.485875v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: National Institute of Allergy and Infectious Diseases, National Institutes of Health
Keywords: SARS-CoV-2, virus variants, pathology, immune response, primates
Summary of Study: Disease severity among variants is unequal, with a lower viral load and thus reduced clinical disease in Omicron versus Delta variants.
References: PMID: 35971544 / doi: 10.1101/2022.08.01.502390
Contact Info: Neeltje van Doremalen: neeltje.vandoremalen@nih.gov; Kyle Rosenke: kyle.rosenke@nih.gov
URL: https://www.biorxiv.org/content/10.1101/2022.08.01.502390v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: National Institute of Allergy and Infectious Diseases, National Institutes of Health
Keywords: SARS-CoV-2, virus variants, pathology, immune response, primates
Summary of Study: Disease severity among variants is unequal, with a lower viral load and thus reduced clinical disease in Omicron versus Delta variants.
References: PMID: 35971544 / doi: 10.1101/2022.08.01.502390
Contact Info: Neeltje van Doremalen: neeltje.vandoremalen@nih.gov; Kyle Rosenke: kyle.rosenke@nih.gov
URL: https://www.biorxiv.org/content/10.1101/2022.08.01.502390v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Sarafan ChEM-H, Stanford University, Stanford, CA; Department of Chemistry, Stanford University, Stanford, CA; Department of Biochemistry, School of Medicine, Stanford University, Stanford, CA; others
Keywords: SARS-CoV-2, ferritin-based, protein-nanoparticle vaccine, immune response, booster, primates
Summary of Study: A ferritin-based COVID-19 nanoparticle vaccine
References: doi: 10.1101/2022.12.25.521784
Contact Info: Peter S Kim: kimpeter@stanford.edu
URL: https://www.biorxiv.org/content/10.1101/2022.12.25.521784v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Sarafan ChEM-H, Stanford University, Stanford, CA; Department of Chemistry, Stanford University, Stanford, CA; Department of Biochemistry, School of Medicine, Stanford University, Stanford, CA; others
Keywords: SARS-CoV-2, ferritin-based, protein-nanoparticle vaccine, immune response, booster, primates
Summary of Study: A ferritin-based COVID-19 nanoparticle vaccine
References: doi: 10.1101/2022.12.25.521784
Contact Info: Peter S Kim: kimpeter@stanford.edu
URL: https://www.biorxiv.org/content/10.1101/2022.12.25.521784v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: California National Primate Research Center; University of California, Davis; Vitalant Research Institute; University of California, Irvine School of Medicine; DMID/NIAID/NIH; University of California, San Francisco
Keywords: SARS-CoV-2, convalescent plasma, immune response, pathology, primates
Summary of Study: While administration of CCP did not result in a detectable reduction in virus replication in the respiratory tract, it significantly reduced lung inflammation. in macaques infected with SARS-CoV-2.
References: PMID: 34494025 / doi: 10.1101/2021.09.01.458520
Contact Info: Koen Van Rompay: kkvanrompay@ucdavis.edu; Rachel Reader: rreader@ucdavis.edu; Michael Busch: mbusch@vitalant.org
URL: https://www.biorxiv.org/content/10.1101/2021.09.01.458520v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: California National Primate Research Center; University of California, Davis; Vitalant Research Institute; University of California, Irvine School of Medicine; DMID/NIAID/NIH; University of California, San Francisco
Keywords: SARS-CoV-2, convalescent plasma, immune response, pathology, primates
Summary of Study: While administration of CCP did not result in a detectable reduction in virus replication in the respiratory tract, it significantly reduced lung inflammation. in macaques infected with SARS-CoV-2.
References: PMID: 34494025 / doi: 10.1101/2021.09.01.458520
Contact Info: Koen Van Rompay: kkvanrompay@ucdavis.edu; Rachel Reader: rreader@ucdavis.edu; Michael Busch: mbusch@vitalant.org
URL: https://www.biorxiv.org/content/10.1101/2021.09.01.458520v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Washington National Primate Research Center; North Carolina State University College of Veterinary Medicine; University of Washington.
Keywords: SARS-CoV-2, single cell immune repertoire profiling, gene expression, primates
Summary of Study: Results establish the ability to perform high throughput scIRS analyusis in rhesus macaques with comparable performances to commercially available platforms.
References: doi: 10.1101/2021.08.17.456682
Contact Info: Xinxia Peng: xpeng5@ncsu.edu
URL: https://www.biorxiv.org/content/10.1101/2021.08.17.456682v1.supplementary-mater…
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Washington National Primate Research Center; North Carolina State University College of Veterinary Medicine; University of Washington.
Keywords: SARS-CoV-2, single cell immune repertoire profiling, gene expression, primates
Summary of Study: Results establish the ability to perform high throughput scIRS analyusis in rhesus macaques with comparable performances to commercially available platforms.
References: doi: 10.1101/2021.08.17.456682
Contact Info: Xinxia Peng: xpeng5@ncsu.edu
URL: https://www.biorxiv.org/content/10.1101/2021.08.17.456682v1.supplementary-mater…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; Henan Normal University; Guangzhou Medical University; Fudan University
Keywords: SARS-CoV-2, inflammation, lung pathology, immune response, primates
Summary of Study: SARS-CoV-2 triggers an immediate mast cell (MC) degranulation, which initiates the alveolar epithelial inflammation and disrupts the tight junction. MC stabilizers that block degranulation reduce virus-induced lung inflammation and injury.
References: doi: 10.1101/2021.06.24.449680
Contact Info: Jian-Hua Wang: wang_jianhua@gibh.ac.cn
URL: https://www.biorxiv.org/content/10.1101/2021.06.24.449680v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; Henan Normal University; Guangzhou Medical University; Fudan University
Keywords: SARS-CoV-2, inflammation, lung pathology, immune response, primates
Summary of Study: SARS-CoV-2 triggers an immediate mast cell (MC) degranulation, which initiates the alveolar epithelial inflammation and disrupts the tight junction. MC stabilizers that block degranulation reduce virus-induced lung inflammation and injury.
References: doi: 10.1101/2021.06.24.449680
Contact Info: Jian-Hua Wang: wang_jianhua@gibh.ac.cn
URL: https://www.biorxiv.org/content/10.1101/2021.06.24.449680v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: University of Liverpool, Public Health England, University of Bristol, and others
Keywords: SARS-CoV-2, the leader-transcriptional regulatory sequence gene junction, high resolution sequencing, primates
Summary of Study: LeTRS, a bioinformatics tool, identified known leader-TRS-junctions and identified novel species that were common across different species. The data indicated multi-phasic abundance of sgmRNAs in two different NHP models, with spikes in sgmRNA abundance reflected in human samples, and therefore has implications for transmission models and nucleic acid-based diagnostics.
References: doi: 10.1101/2021.03.03.433753
Contact Info: Julian Hiscox: julian.hiscox@liverpool.ac.uk
URL: https://www.biorxiv.org/content/10.1101/2021.03.03.433753v2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: University of Liverpool, Public Health England, University of Bristol, and others
Keywords: SARS-CoV-2, the leader-transcriptional regulatory sequence gene junction, high resolution sequencing, primates
Summary of Study: LeTRS, a bioinformatics tool, identified known leader-TRS-junctions and identified novel species that were common across different species. The data indicated multi-phasic abundance of sgmRNAs in two different NHP models, with spikes in sgmRNA abundance reflected in human samples, and therefore has implications for transmission models and nucleic acid-based diagnostics.
References: doi: 10.1101/2021.03.03.433753
Contact Info: Julian Hiscox: julian.hiscox@liverpool.ac.uk
URL: https://www.biorxiv.org/content/10.1101/2021.03.03.433753v2
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: SL VaxiGen Inc., Genexine Inc., Sorea Bio Park, Scongnam, Republic of Korea
Keywords: SARS-CoV-2, DNA-based vaccine candidate, GX-19, immunization, primates
Summary of Study: Vaccination with vaccine candidate GX-19 elicits a concurrent humoral response and Th1-biased immune responses in both mice and non-human primate models. In NHPs this response includes neutralizing antibodies that provide potent protective efficacy against SARS-CoV-2 infection.
References: doi: https://doi.org/10.1101/2020.10.09.334136
Contact Info: Young Chul Sung: ycsung@genexine.com
URL: https://www.biorxiv.org/content/10.1101/2020.10.09.334136v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: SL VaxiGen Inc., Genexine Inc., Sorea Bio Park, Scongnam, Republic of Korea
Keywords: SARS-CoV-2, DNA-based vaccine candidate, GX-19, immunization, primates
Summary of Study: Vaccination with vaccine candidate GX-19 elicits a concurrent humoral response and Th1-biased immune responses in both mice and non-human primate models. In NHPs this response includes neutralizing antibodies that provide potent protective efficacy against SARS-CoV-2 infection.
References: doi: https://doi.org/10.1101/2020.10.09.334136
Contact Info: Young Chul Sung: ycsung@genexine.com
URL: https://www.biorxiv.org/content/10.1101/2020.10.09.334136v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Eli Lilly & Co.; NIAID
Keywords: SARS-CoV-2, anti-spike neutralizing antibodies, primate challenge model
Summary of Study: Prophylactic treatment with LY-CoV555 (a neutralizing antibody) resulted in significant decreases in viral load (gRNA) and viral replication (sgRNA) in the lower respiratory tract of rhesus macaques following SARS-CoV2 inoculation, based on determination in BAL and lung tissue.
References: doi:Â https://doi.org/10.1101/2020.09.30.318972
Contact Info: Bryan Jones: jones_bryan_edward@lilly.com; Ester Falconer: ester.falconer@abcellera.com
URL: https://www.biorxiv.org/content/10.1101/2020.09.30.318972v3
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Eli Lilly & Co.; NIAID
Keywords: SARS-CoV-2, anti-spike neutralizing antibodies, primate challenge model
Summary of Study: Prophylactic treatment with LY-CoV555 (a neutralizing antibody) resulted in significant decreases in viral load (gRNA) and viral replication (sgRNA) in the lower respiratory tract of rhesus macaques following SARS-CoV2 inoculation, based on determination in BAL and lung tissue.
References: doi:Â https://doi.org/10.1101/2020.09.30.318972
Contact Info: Bryan Jones: jones_bryan_edward@lilly.com; Ester Falconer: ester.falconer@abcellera.com
URL: https://www.biorxiv.org/content/10.1101/2020.09.30.318972v3
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: NIAID/NIH
Keywords: SARS-CoV-2, virus variants, pathogenicity, immune response, primates
Summary of Study: A side-by-side comparison of three SARS-CoV-2 varients sugests that ongoing circulation under diverse evolutionary pressures favors transmissibility and immune evasion rather than an increase in intrinsic pathogenicity.
References: PMID: 34382034 / doi: 10.1101/2021.05.07.443115
Contact Info: Emmie de Wit: emmie.dewit@nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.05.07.443115v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: NIAID/NIH
Keywords: SARS-CoV-2, virus variants, pathogenicity, immune response, primates
Summary of Study: A side-by-side comparison of three SARS-CoV-2 varients sugests that ongoing circulation under diverse evolutionary pressures favors transmissibility and immune evasion rather than an increase in intrinsic pathogenicity.
References: PMID: 34382034 / doi: 10.1101/2021.05.07.443115
Contact Info: Emmie de Wit: emmie.dewit@nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.05.07.443115v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: MIT, Harvard Medical School, Vaccine Analytics and Formulation Center (Univ. of Kansas), Cummings School of Veterinary Medicine (Tufts Univ.), SpyBiotech Ltd., Bioqual, Bill & Melinda Gates Fdtn.
Keywords: SARS-CoV-2, protein subunit vaccine, manufacturing, preclinical testing, primates
Summary of Study: A modular protein subunit vaccine candidate elicits a strong immune response in cynomolgus macaques and protects against SARS-CoV-2 challenge. This vaccine candidate is currently being tested in clinical trials (ANZCTR Registration number ACTRN12620000817943).
References: PMID: 34282417 / doi: 10.1101/2021.07.13.452251
Contact Info: Dan Barouch: abarouch@bidmc.harvard.edu; J. Christopher Love: clove@mit.edu
URL: https://www.biorxiv.org/content/10.1101/2021.07.13.452251v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: MIT, Harvard Medical School, Vaccine Analytics and Formulation Center (Univ. of Kansas), Cummings School of Veterinary Medicine (Tufts Univ.), SpyBiotech Ltd., Bioqual, Bill & Melinda Gates Fdtn.
Keywords: SARS-CoV-2, protein subunit vaccine, manufacturing, preclinical testing, primates
Summary of Study: A modular protein subunit vaccine candidate elicits a strong immune response in cynomolgus macaques and protects against SARS-CoV-2 challenge. This vaccine candidate is currently being tested in clinical trials (ANZCTR Registration number ACTRN12620000817943).
References: PMID: 34282417 / doi: 10.1101/2021.07.13.452251
Contact Info: Dan Barouch: abarouch@bidmc.harvard.edu; J. Christopher Love: clove@mit.edu
URL: https://www.biorxiv.org/content/10.1101/2021.07.13.452251v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Harvard Medical School; Walter Reed National Military Medical Center; Ragon Institute of MGH, MIT and Harvard; Bioqual; University of Pittsburgh; Henry Jackson Foundation
Keywords: SARS-CoV-2, live oral vaccine, immune response, pathology, primates
Summary of Study: Post-pyloric inoculation of live SARS-CoV-2 is weakly immunogenic and confers partial protection against respiratory SARS-CoV-2 challenge in rhesus macaques.
References: doi: 10.1101/2021.09.13.460191
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.biorxiv.org/content/10.1101/2021.09.13.460191v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Harvard Medical School; Walter Reed National Military Medical Center; Ragon Institute of MGH, MIT and Harvard; Bioqual; University of Pittsburgh; Henry Jackson Foundation
Keywords: SARS-CoV-2, live oral vaccine, immune response, pathology, primates
Summary of Study: Post-pyloric inoculation of live SARS-CoV-2 is weakly immunogenic and confers partial protection against respiratory SARS-CoV-2 challenge in rhesus macaques.
References: doi: 10.1101/2021.09.13.460191
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.biorxiv.org/content/10.1101/2021.09.13.460191v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Yerkes National Primate Research Center, Emory University; Emory University School of Medicine; University of Pittsburgh
Keywords: SARS-CoV-2, multi-omic analyses, inflammation, immune response, primates
Summary of Study: Multi-omic analyses of hyperacute SARS-CoV-2 infection in rhesus macaques identified two populations of infiltrating macrophages as the primary orchestrators of inflammation in th elowre airway that can be successfully treated with baricitinib.
References: PMID: 34642693 / doi: 10.1101/2021.10.05.463212
Contact Info: Steven Bosinger: steven.bosinger@emory.edu; Mirko Paiardini: mirko.paiardini@emory.edu
URL: https://www.biorxiv.org/content/10.1101/2021.10.05.463212v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Yerkes National Primate Research Center, Emory University; Emory University School of Medicine; University of Pittsburgh
Keywords: SARS-CoV-2, multi-omic analyses, inflammation, immune response, primates
Summary of Study: Multi-omic analyses of hyperacute SARS-CoV-2 infection in rhesus macaques identified two populations of infiltrating macrophages as the primary orchestrators of inflammation in th elowre airway that can be successfully treated with baricitinib.
References: PMID: 34642693 / doi: 10.1101/2021.10.05.463212
Contact Info: Steven Bosinger: steven.bosinger@emory.edu; Mirko Paiardini: mirko.paiardini@emory.edu
URL: https://www.biorxiv.org/content/10.1101/2021.10.05.463212v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Pasteur Institute of Iran; University of Tehran; Biosunpharmed Co, Tehran; and others
Keywords: SARS-CoV-2, inactivated whole-virus vaccine, immune response, mice, guinea pig, rabbit and primates
Summary of Study: COVIran Barekat, an inactivated whole-virus SARS-CoV-2 candidate vaccine, elicited a high level of SARS-CoV-2 specific neutralizing antibodies in mice, rabbits, and rhesus macaques.
References: doi: 10.1101/2021.06.10.44.447951
Contact Info: Reza Aalizadeh: allizadehreza19@gmail.com; Hasan Jalili: hjalili@ut.ac.ir
URL: https://www.biorxiv.org/content/10.1101/2021.06.10.447951v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Pasteur Institute of Iran; University of Tehran; Biosunpharmed Co, Tehran; and others
Keywords: SARS-CoV-2, inactivated whole-virus vaccine, immune response, mice, guinea pig, rabbit and primates
Summary of Study: COVIran Barekat, an inactivated whole-virus SARS-CoV-2 candidate vaccine, elicited a high level of SARS-CoV-2 specific neutralizing antibodies in mice, rabbits, and rhesus macaques.
References: doi: 10.1101/2021.06.10.44.447951
Contact Info: Reza Aalizadeh: allizadehreza19@gmail.com; Hasan Jalili: hjalili@ut.ac.ir
URL: https://www.biorxiv.org/content/10.1101/2021.06.10.447951v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: ReiThera Sri, Rome, Italy; The University of Nottingham
Keywords: SARS-CoV-2, gorilla adenovirus-vectored vaccine, primates
Summary of Study: Vaccine candidate, GRAd-COV2, is highly immunogenic in both mice and cynomolgus macaques, eliciting both functional antibodies which neutralize SARS-CoV-2 infection and block Spike protein binding to the ACE2 receptor, and a robust, Th1-dominated cellular response in the periphery and in the lung.
References: doi: https://doi.org/10.1101/2020.10.22.349951
Contact Info: Alessandra Vitelli: alessandra.vitelli@reithera.com
URL: https://www.biorxiv.org/content/10.1101/2020.10.22.349951v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: ReiThera Sri, Rome, Italy; The University of Nottingham
Keywords: SARS-CoV-2, gorilla adenovirus-vectored vaccine, primates
Summary of Study: Vaccine candidate, GRAd-COV2, is highly immunogenic in both mice and cynomolgus macaques, eliciting both functional antibodies which neutralize SARS-CoV-2 infection and block Spike protein binding to the ACE2 receptor, and a robust, Th1-dominated cellular response in the periphery and in the lung.
References: doi: https://doi.org/10.1101/2020.10.22.349951
Contact Info: Alessandra Vitelli: alessandra.vitelli@reithera.com
URL: https://www.biorxiv.org/content/10.1101/2020.10.22.349951v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: BioNTech, Mainz, Germany
Keywords: SARS-CoV-2, BNT162b vaccine, primates
Summary of Study: Prime/boost vaccination of rhesus macaques with BNT162b candidates protect macaques from SARS-CoV-2 challenge. Both candidates are being evaluated in phase 1 trials in Germany and the US.
References: doi: https://doi.org/10.1101/2020.12.11.421008
Contact Info: Ugur Sahin: ugur.sahin@biontech.de
URL: https://www.biorxiv.org/content/10.1101/2020.12.11.421008v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: BioNTech, Mainz, Germany
Keywords: SARS-CoV-2, BNT162b vaccine, primates
Summary of Study: Prime/boost vaccination of rhesus macaques with BNT162b candidates protect macaques from SARS-CoV-2 challenge. Both candidates are being evaluated in phase 1 trials in Germany and the US.
References: doi: https://doi.org/10.1101/2020.12.11.421008
Contact Info: Ugur Sahin: ugur.sahin@biontech.de
URL: https://www.biorxiv.org/content/10.1101/2020.12.11.421008v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: University of Oxford
Keywords: SARS-CoV-2, protein nanoparticle vaccine, primates
Summary of Study: Ferrets and rhesus macaques were challenged with SARCS-CoV-2 to assess the potential for vaccine-enhanced disease (VED) in animals vaccinated with formaldehyde-inactivated SARS-CoV-2 formulated with Alhydrogel. This study revealed no evidence of enhanced disease in rhesus macaques.
References: doi: https://doi.org/10.1101/2020.12.21.423746
Contact Info: Andrew Gorringe: andrew.gorringe@phe.gov.uk
URL: https://www.biorxiv.org/content/10.1101/2020.12.21.423746v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: University of Oxford
Keywords: SARS-CoV-2, protein nanoparticle vaccine, primates
Summary of Study: Ferrets and rhesus macaques were challenged with SARCS-CoV-2 to assess the potential for vaccine-enhanced disease (VED) in animals vaccinated with formaldehyde-inactivated SARS-CoV-2 formulated with Alhydrogel. This study revealed no evidence of enhanced disease in rhesus macaques.
References: doi: https://doi.org/10.1101/2020.12.21.423746
Contact Info: Andrew Gorringe: andrew.gorringe@phe.gov.uk
URL: https://www.biorxiv.org/content/10.1101/2020.12.21.423746v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: NIAID; La Jolla Institute for Immunology; University of California; University of Capetown
Keywords: SARS-CoV-2, viral replication, pathogenesis. Immune response, primates
Summary of Study: SARS-CoV-2 infection leads to mild, focal lung inflammation, and type 1 IFN activated myeloid cells that mostly resolve prior to the influx of virus-specific effector T cells or antibody responses in rhesus macaques.
References: doi: 10.1101/2022.01.06.475282
Contact Info: Daniel Barber: barberd@niaid.nih.gov
URL: https://www.biorxiv.org/content/10.1101/2022.01.06.475282v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: NIAID; La Jolla Institute for Immunology; University of California; University of Capetown
Keywords: SARS-CoV-2, viral replication, pathogenesis. Immune response, primates
Summary of Study: SARS-CoV-2 infection leads to mild, focal lung inflammation, and type 1 IFN activated myeloid cells that mostly resolve prior to the influx of virus-specific effector T cells or antibody responses in rhesus macaques.
References: doi: 10.1101/2022.01.06.475282
Contact Info: Daniel Barber: barberd@niaid.nih.gov
URL: https://www.biorxiv.org/content/10.1101/2022.01.06.475282v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Shanghai Jemincare Pharmaceuticles, Wuhan Institute of Virology, and others
Keywords: SARS-CoV-2, antivirus antibodies, prophylactic and potent therapeutic efficacy, primates
Summary of Study: Antibody JMB2002 demonstrated complete prophylactic and potent therapeutic efficacy in a rhesus macaque disease model.
References: doi: 10.1101/2021.02.07.429299
Contact Info: Wuxiang Guan: dengsujun@jemincare.com
URL: https://www.biorxiv.org/content/10.1101/2021.02.07.429299v2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Shanghai Jemincare Pharmaceuticles, Wuhan Institute of Virology, and others
Keywords: SARS-CoV-2, antivirus antibodies, prophylactic and potent therapeutic efficacy, primates
Summary of Study: Antibody JMB2002 demonstrated complete prophylactic and potent therapeutic efficacy in a rhesus macaque disease model.
References: doi: 10.1101/2021.02.07.429299
Contact Info: Wuxiang Guan: dengsujun@jemincare.com
URL: https://www.biorxiv.org/content/10.1101/2021.02.07.429299v2
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: Inserm, CEA, Paris, France; University of Amsterdam; and others
Keywords: SARS-CoV-2, prophylactic and therapeutic effect of COVA1-18 in vivo, several species, primates
Summary of Study: COVA1-18, a neutralizing antibody isolated from a convalescent patient and highly potent against the B.1.1.7 isolate, had very strong antiviral activity in the upper respiratory compartments of cynomolgus macaques, with an estimated reduction in viral infectivity of more than 95%, and prevented lymphopenia and extensive lung lesions.
References: PMID: 33619476 / doi: 10.21203/rs.3.rs-235272/v1
Contact Info: Roger LeGrand: roger.le-grand@cea.fr; MJ Van Gils: m.j.vangils@amsterdamumc.nl
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899470/pdf/nihpp-rs235272v1.pdf
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: Inserm, CEA, Paris, France; University of Amsterdam; and others
Keywords: SARS-CoV-2, prophylactic and therapeutic effect of COVA1-18 in vivo, several species, primates
Summary of Study: COVA1-18, a neutralizing antibody isolated from a convalescent patient and highly potent against the B.1.1.7 isolate, had very strong antiviral activity in the upper respiratory compartments of cynomolgus macaques, with an estimated reduction in viral infectivity of more than 95%, and prevented lymphopenia and extensive lung lesions.
References: PMID: 33619476 / doi: 10.21203/rs.3.rs-235272/v1
Contact Info: Roger LeGrand: roger.le-grand@cea.fr; MJ Van Gils: m.j.vangils@amsterdamumc.nl
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899470/pdf/nihpp-rs235272v1.pdf
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Novavax, Inc. 21 Firstfield Road, Gaithersburg, MD, 20878
Keywords: SARS-CoV-2, subunit vaccine, pulmonary disease, primates
Summary of Study: Cynomolgus macaques immunized with NVX-CoV2373 and the saponin-based Matrix-M adjuvant induced antibody that was neutralizing and blocked binding to the human angiotensin-converting enzyme 2 (hACE2) receptor. Following intranasal and intratracheal challenge with SARS-CoV-2, immunized macaques were protected against upper and lower infection and pulmonary disease.
References: doi: https://doi.org/10.1101/2020.08.18.256578
Contact Info: Gale Smith at gsmith@Novavax.com
URL: https://www.biorxiv.org/content/10.1101/2020.08.18.256578v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Novavax, Inc. 21 Firstfield Road, Gaithersburg, MD, 20878
Keywords: SARS-CoV-2, subunit vaccine, pulmonary disease, primates
Summary of Study: Cynomolgus macaques immunized with NVX-CoV2373 and the saponin-based Matrix-M adjuvant induced antibody that was neutralizing and blocked binding to the human angiotensin-converting enzyme 2 (hACE2) receptor. Following intranasal and intratracheal challenge with SARS-CoV-2, immunized macaques were protected against upper and lower infection and pulmonary disease.
References: doi: https://doi.org/10.1101/2020.08.18.256578
Contact Info: Gale Smith at gsmith@Novavax.com
URL: https://www.biorxiv.org/content/10.1101/2020.08.18.256578v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Yerkes NPRC, NIH, Ragon Institute, and others
Keywords: SARS-CoV-2, adjuvanted soluble protein vaccines, binding and functional neutralization assays and systems serology, primates
Summary of Study: Potent serum antibody responses are induced by soluble S trimers formulated with the oil-in-water emulsion adjuvant AS03, which conferred protection in the upper and lower airways of rhesus macaques following SARS-CoV-2 challenge.
References: PMID: 33688652 / doi: 10.1101/2021.03.02.433390
Contact Info: Robert Seder: rseder@mail.nih.gov
URL: https://pubmed.ncbi.nlm.nih.gov/33688652/
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Yerkes NPRC, NIH, Ragon Institute, and others
Keywords: SARS-CoV-2, adjuvanted soluble protein vaccines, binding and functional neutralization assays and systems serology, primates
Summary of Study: Potent serum antibody responses are induced by soluble S trimers formulated with the oil-in-water emulsion adjuvant AS03, which conferred protection in the upper and lower airways of rhesus macaques following SARS-CoV-2 challenge.
References: PMID: 33688652 / doi: 10.1101/2021.03.02.433390
Contact Info: Robert Seder: rseder@mail.nih.gov
URL: https://pubmed.ncbi.nlm.nih.gov/33688652/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences
Keywords: SARS-CoV-2, interferon (IFN)-armed receptor-binding domain, immune response, primates
Summary of Study: The pan-epitope modified human I-R-F (I-P-R-F) vaccine provides rapid and complete protection throughout the upper and lower respiratory tracts against a high-dose SARS-CoV-2 challenge in rhesus macaques.
References: doi: 10.1038/s41422-021-00531-8
Contact Info: Hua Peng: https://www.nature.com/articles/s41422-021-00531-8/email/correspondent/c3/new
URL: https://www.nature.com/articles/s41422-021-00531-8
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences
Keywords: SARS-CoV-2, interferon (IFN)-armed receptor-binding domain, immune response, primates
Summary of Study: The pan-epitope modified human I-R-F (I-P-R-F) vaccine provides rapid and complete protection throughout the upper and lower respiratory tracts against a high-dose SARS-CoV-2 challenge in rhesus macaques.
References: doi: 10.1038/s41422-021-00531-8
Contact Info: Hua Peng: https://www.nature.com/articles/s41422-021-00531-8/email/correspondent/c3/new
URL: https://www.nature.com/articles/s41422-021-00531-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Harvard Medical School
Keywords: SARS-CoV-2, Multiplexed proteomics and imaging, acute respiratory distress, primates
Summary of Study: The data in this paper highlight the ability of proteomics, imaging, and spatial transcriptomics of the same specimens to trace successive steps in diverse regulatory cascades. This approach is applicable to any fixed tissue. No other approach involving readily available histological specimens provides a similarly integrated picture of a disease process.
References: doi: https://doi.org/10.1101/2020.10.14.339952
Contact Info: Marian Kalocsay: marian_kalocsay@hms.harvard.edu; Peter Sorger: peter_sorger@hms.harvard.edu
URL: https://www.biorxiv.org/content/10.1101/2020.10.14.339952v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Harvard Medical School
Keywords: SARS-CoV-2, Multiplexed proteomics and imaging, acute respiratory distress, primates
Summary of Study: The data in this paper highlight the ability of proteomics, imaging, and spatial transcriptomics of the same specimens to trace successive steps in diverse regulatory cascades. This approach is applicable to any fixed tissue. No other approach involving readily available histological specimens provides a similarly integrated picture of a disease process.
References: doi: https://doi.org/10.1101/2020.10.14.339952
Contact Info: Marian Kalocsay: marian_kalocsay@hms.harvard.edu; Peter Sorger: peter_sorger@hms.harvard.edu
URL: https://www.biorxiv.org/content/10.1101/2020.10.14.339952v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: SWNPRC/BioNtech
Keywords: SARS-CoV-2, RNA vaccine, immune response, mice, primates
Summary of Study: This study challenged immunization with the BNT162b2 vaccine candidate containing mRNA encoding for the spike glycoprotein in mice and monkeys. Immunization in mice induced a strong immune response and immunization in monkeys fully protected the animal's lungs from SARS-CoV-2 infection.
References: doi: 10.1101/2020.09.08.280818
Contact Info: Ugur Sahin; Email: Ugur.Sahin@biontech.de
URL: https://www.biorxiv.org/content/10.1101/2020.09.08.280818v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: SWNPRC/BioNtech
Keywords: SARS-CoV-2, RNA vaccine, immune response, mice, primates
Summary of Study: This study challenged immunization with the BNT162b2 vaccine candidate containing mRNA encoding for the spike glycoprotein in mice and monkeys. Immunization in mice induced a strong immune response and immunization in monkeys fully protected the animal's lungs from SARS-CoV-2 infection.
References: doi: 10.1101/2020.09.08.280818
Contact Info: Ugur Sahin; Email: Ugur.Sahin@biontech.de
URL: https://www.biorxiv.org/content/10.1101/2020.09.08.280818v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Duke University School of Medicine; University of North Carolina at Chapel Hill; NIAID; Division of Viral Products, FDA; Beth Israel Deaconess Medical Center; Univerity of Pennsylvania; Corporate Research Materials Lab, 3M Company; Infectious Disease Research Institute; BIOQUAL
Keywords: SARS-CoV-2, ferritin nanoparticle (RBD-scNP) vaccine, virus variants, immune response, primates
Summary of Study: Study demonstrates that scNP vaccines wth SARS-CoV-2 spike or spike subunits confer potent protection in NHPs against WA-1, Beta and Delta variants, and that they induce neutralizing antibodies to all SARS-CoV-2 variants tested in vitro.
References: doi: 10.1101/2022.01.26.477915
Contact Info: Kevin Saunders: kevin.saunders@duke.edu; Barton Haynes: barton.haynes@duke.edu
URL: https://www.biorxiv.org/content/10.1101/2022.01.26.477915v2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Duke University School of Medicine; University of North Carolina at Chapel Hill; NIAID; Division of Viral Products, FDA; Beth Israel Deaconess Medical Center; Univerity of Pennsylvania; Corporate Research Materials Lab, 3M Company; Infectious Disease Research Institute; BIOQUAL
Keywords: SARS-CoV-2, ferritin nanoparticle (RBD-scNP) vaccine, virus variants, immune response, primates
Summary of Study: Study demonstrates that scNP vaccines wth SARS-CoV-2 spike or spike subunits confer potent protection in NHPs against WA-1, Beta and Delta variants, and that they induce neutralizing antibodies to all SARS-CoV-2 variants tested in vitro.
References: doi: 10.1101/2022.01.26.477915
Contact Info: Kevin Saunders: kevin.saunders@duke.edu; Barton Haynes: barton.haynes@duke.edu
URL: https://www.biorxiv.org/content/10.1101/2022.01.26.477915v2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute, Henry M. Jackson Foundation for the Advancement of Military Medicine, NCI, BIOQUAL, Texas Biomedical Research Institute, Columbia University
Keywords: SARS-CoV-2, ferritin nanoparticle vaccine, immune response, primates
Summary of Study: Evaluation of a SARS-CoV-2 Spike receptor-binding doman ferritin nanoparticle protein vaccine (RFN), adjuvanted with a liposomal-QS21 formulation (ALFQ) elicits humoral and cellular immune responses exceeding those of current vaccines.
References: PMID: 33851155 / doi: 10.1101/2021.04.09.439166
Contact Info: Diane Bolton: dbolton@hivresearch.org; Kayvon Modjarrad: kayvon.modjarrad.cov@mail.mil
URL: https://www.biorxiv.org/content/10.1101/2021.04.09.439166v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute, Henry M. Jackson Foundation for the Advancement of Military Medicine, NCI, BIOQUAL, Texas Biomedical Research Institute, Columbia University
Keywords: SARS-CoV-2, ferritin nanoparticle vaccine, immune response, primates
Summary of Study: Evaluation of a SARS-CoV-2 Spike receptor-binding doman ferritin nanoparticle protein vaccine (RFN), adjuvanted with a liposomal-QS21 formulation (ALFQ) elicits humoral and cellular immune responses exceeding those of current vaccines.
References: PMID: 33851155 / doi: 10.1101/2021.04.09.439166
Contact Info: Diane Bolton: dbolton@hivresearch.org; Kayvon Modjarrad: kayvon.modjarrad.cov@mail.mil
URL: https://www.biorxiv.org/content/10.1101/2021.04.09.439166v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: COVAXX, United Biomedical< Inc., United BioPharma, Academic Sinica, University of Texas Medical Branch, Galveston National Library
Keywords: SARS-CoV-2, multitope protein-peptide vaccine, immune response, toxicity, protection, guinea pigs, rats, primates
Summary of Study: The authors have developed and demonstrated proof of concept for UB-612, a novel multitope protein-peptide vaccine being rapidly advanced in clinical trials for prevention of SARS-CoV-2 infection and COVID-19. Extremely high levels of neutralizing antibodies were shown and Th1 prone immune response was induced by the vaccine that protected animals, challenged by a high dose of SARS-CoV-2, without induction of immunopathology in the lungs.
References: doi: 10.1101/2020.11.30.399154
Contact Info: Chang Yi Wang: cywang@unitedbiomedical.com
URL: https://www.biorxiv.org/content/10.1101/2020.11.30.399154v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: COVAXX, United Biomedical< Inc., United BioPharma, Academic Sinica, University of Texas Medical Branch, Galveston National Library
Keywords: SARS-CoV-2, multitope protein-peptide vaccine, immune response, toxicity, protection, guinea pigs, rats, primates
Summary of Study: The authors have developed and demonstrated proof of concept for UB-612, a novel multitope protein-peptide vaccine being rapidly advanced in clinical trials for prevention of SARS-CoV-2 infection and COVID-19. Extremely high levels of neutralizing antibodies were shown and Th1 prone immune response was induced by the vaccine that protected animals, challenged by a high dose of SARS-CoV-2, without induction of immunopathology in the lungs.
References: doi: 10.1101/2020.11.30.399154
Contact Info: Chang Yi Wang: cywang@unitedbiomedical.com
URL: https://www.biorxiv.org/content/10.1101/2020.11.30.399154v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: The 4th R&D Institute, Agency for Defense Development, Yuseong, P.O. Box 35, Daejeon 34186, Republic of Korea
Keywords: SARS-CoV-2, siRNA inhibitors, hamster and primates
Summary of Study: An siRNA targeting RNA-dependent RNA polymerase (RdRp) showed a reduction in SARS-CoV-2 infection-induced fever and virus titer in the Golden Syrian hamster and rhesus macaque. These results suggest the potential for RdRp targeting siRNA as a new treatment for the coronavirus disease 2019 (COVID-19).
References: doi: https://doi.org/10.1101/2020.07.07.190967
Contact Info: Seong Tae Jeong at birdyjeong@add.re.kr
URL: https://www.biorxiv.org/content/10.1101/2020.07.07.190967v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: The 4th R&D Institute, Agency for Defense Development, Yuseong, P.O. Box 35, Daejeon 34186, Republic of Korea
Keywords: SARS-CoV-2, siRNA inhibitors, hamster and primates
Summary of Study: An siRNA targeting RNA-dependent RNA polymerase (RdRp) showed a reduction in SARS-CoV-2 infection-induced fever and virus titer in the Golden Syrian hamster and rhesus macaque. These results suggest the potential for RdRp targeting siRNA as a new treatment for the coronavirus disease 2019 (COVID-19).
References: doi: https://doi.org/10.1101/2020.07.07.190967
Contact Info: Seong Tae Jeong at birdyjeong@add.re.kr
URL: https://www.biorxiv.org/content/10.1101/2020.07.07.190967v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Medicago, Inc.; Stanford University; Tulane University School of Medicine; McGill University
Keywords: SARS-CoV-2, plant-derived virus-like particle vaccine, immune response, pathology, primates
Summary of Study: Although a single dose of an unadjuvanted virus-like particle (VLP) bearing SARS-CoV-2 spike protein vaccine candidate stimulated humoral and cell-mediated immune responses, booster immunization (at 28 days after prime) and adjuvants significantly improved both responses with a higher immunogenicity and protection provided by AS03 adjuvanted CoVLP.
References: doi: 10.1101.2021.05.15.444262
Contact Info: Nathalie Landry: landryn@medicago.com
URL: https://www.biorxiv.org/content/10.1101/2021.05.15.444262v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Medicago, Inc.; Stanford University; Tulane University School of Medicine; McGill University
Keywords: SARS-CoV-2, plant-derived virus-like particle vaccine, immune response, pathology, primates
Summary of Study: Although a single dose of an unadjuvanted virus-like particle (VLP) bearing SARS-CoV-2 spike protein vaccine candidate stimulated humoral and cell-mediated immune responses, booster immunization (at 28 days after prime) and adjuvants significantly improved both responses with a higher immunogenicity and protection provided by AS03 adjuvanted CoVLP.
References: doi: 10.1101.2021.05.15.444262
Contact Info: Nathalie Landry: landryn@medicago.com
URL: https://www.biorxiv.org/content/10.1101/2021.05.15.444262v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: Duke NUS Medical School, Singapore; Duke University Medical School
Keywords: SARS-CoV-2, lung inflammation, pathology, mice and primates
Summary of Study: Widespread degranulation of mast cells (MCs) during acute and unresolved airway inflammation in SARS-CoV-2-infected mice and non-human primates supports the association of MC activation with severe COVID-19 and suggests potential strategies for intervention.
References: PMID: 34100020 / doi: 10.1101.2021.05.31.21255594
Contact Info: Ashley St. John: ashley.st.john@duke.nus.edu.sg
URL: https://www.medrxiv.org/content/10.1101/2021.05.31.21255594v1
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: Duke NUS Medical School, Singapore; Duke University Medical School
Keywords: SARS-CoV-2, lung inflammation, pathology, mice and primates
Summary of Study: Widespread degranulation of mast cells (MCs) during acute and unresolved airway inflammation in SARS-CoV-2-infected mice and non-human primates supports the association of MC activation with severe COVID-19 and suggests potential strategies for intervention.
References: PMID: 34100020 / doi: 10.1101.2021.05.31.21255594
Contact Info: Ashley St. John: ashley.st.john@duke.nus.edu.sg
URL: https://www.medrxiv.org/content/10.1101/2021.05.31.21255594v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: NIAID/NIH; The Jenner Institute at the University of Oxford
Keywords: SARS-CoV-2, multiomics profiling, young and old animals, immune response, primates
Summary of Study: Despite similar disease outcomes, multi-omics profiling in SARS-CoV-2-infected rhesus macaques suggests that age may delay or impair the induction of anti-viral cellular immune responses and delay efficient return to immune homeostasis following acute infection.
References: doi: 10.1101/2021.09.08.459430
Contact Info: Emmie de Wit: emmie.dewit@nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.09.08.459430v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: NIAID/NIH; The Jenner Institute at the University of Oxford
Keywords: SARS-CoV-2, multiomics profiling, young and old animals, immune response, primates
Summary of Study: Despite similar disease outcomes, multi-omics profiling in SARS-CoV-2-infected rhesus macaques suggests that age may delay or impair the induction of anti-viral cellular immune responses and delay efficient return to immune homeostasis following acute infection.
References: doi: 10.1101/2021.09.08.459430
Contact Info: Emmie de Wit: emmie.dewit@nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.09.08.459430v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: National Institute of Infectious Diseases, Tokyo, Japan
Keywords: SARS-CoV-2, T-cell populations, primates
Summary of Study: Results suggest that the peripheral T lymphocyte population is associated with pneumonia severity in cynomolgus monkeys experimentally infected with SARS-CoV-2.
References: doi: https://doi.org/10.1101/2021.01.07.425698
Contact Info: Noriyo Nagata: nnagata@nih.go.jp
URL: https://www.biorxiv.org/content/10.1101/2021.01.07.425698v1
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: National Institute of Infectious Diseases, Tokyo, Japan
Keywords: SARS-CoV-2, T-cell populations, primates
Summary of Study: Results suggest that the peripheral T lymphocyte population is associated with pneumonia severity in cynomolgus monkeys experimentally infected with SARS-CoV-2.
References: doi: https://doi.org/10.1101/2021.01.07.425698
Contact Info: Noriyo Nagata: nnagata@nih.go.jp
URL: https://www.biorxiv.org/content/10.1101/2021.01.07.425698v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Sanofi Pasteur, GSK
Keywords: SARS-CoV-2, virus genomic variants, vaccine boosters, immune response, primates
Summary of Study: One booster dose of AS03-adjuvanted CoV2 preS dTM, D614 (parental) or B.1.351 (Beta), in monovalent of bivalent formulations, significantly booster pre-existing neutralizing antibodies and elicited high and stable cross-neutralizing antibodies covering the four known SARS-CV-2 variants of concern.
References: doi: 10.1101/2021.09.20.461023
Contact Info: Valerie Lecouturier: valerie.lecouturier@sanofi.com
URL: https://www.biorxiv.org/content/10.1101/2021.09.20.461023v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Sanofi Pasteur, GSK
Keywords: SARS-CoV-2, virus genomic variants, vaccine boosters, immune response, primates
Summary of Study: One booster dose of AS03-adjuvanted CoV2 preS dTM, D614 (parental) or B.1.351 (Beta), in monovalent of bivalent formulations, significantly booster pre-existing neutralizing antibodies and elicited high and stable cross-neutralizing antibodies covering the four known SARS-CV-2 variants of concern.
References: doi: 10.1101/2021.09.20.461023
Contact Info: Valerie Lecouturier: valerie.lecouturier@sanofi.com
URL: https://www.biorxiv.org/content/10.1101/2021.09.20.461023v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: SUNY Upstate Medical University; Walter Reed Army Institute of Research; NIAID; Henry M. Jackson Foundation for the Advancement of Military Medicine
Keywords: SARS-CoV-2, mRNA-1273 vaccine, single-cell transcriptomic profiling, virus variants, inflammation, primates
Summary of Study: Single cell RNA sequencing analysis demonstrates that mRNA-1273 vaccination limits the development of lower respiratory tract inflammation in SARS-CoV-2 challenged rhesus macaques.
References: doi: 10.1101/2021.12.24.474132
Contact Info: Robert Seder: rseder@mail.nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.12.24.474132v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: SUNY Upstate Medical University; Walter Reed Army Institute of Research; NIAID; Henry M. Jackson Foundation for the Advancement of Military Medicine
Keywords: SARS-CoV-2, mRNA-1273 vaccine, single-cell transcriptomic profiling, virus variants, inflammation, primates
Summary of Study: Single cell RNA sequencing analysis demonstrates that mRNA-1273 vaccination limits the development of lower respiratory tract inflammation in SARS-CoV-2 challenged rhesus macaques.
References: doi: 10.1101/2021.12.24.474132
Contact Info: Robert Seder: rseder@mail.nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.12.24.474132v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Shanghai Jiao Tong University; Westlake University, China; University of Texas, medical Branch; Jecho Biopharmaceuticals Co.; China CDC; Zhengzhou University People's Hospital; Jecho Laboratories (Frederick, MD)
Keywords: SARS-CoV-2, monoclonal antibody, virus genomic variants, spike protein, mice, primates
Summary of Study: This report characterizes the therapeutic antibodies specific to the tip of spike against SARS-CoV-2 and suggests the potential of antibody treatment with 2G1 to bring clinical benefit to COVID-19 patients.
References: doi: 10.1101/2021.09.24.461616
Contact Info: Lei Han: lei.han@jechobio.com; Hua Jiang: hua.jiang@jecholabs.com; Yueqing Xie: jecholabs.com; Qiang Zhou: zhouqiang@westlake.edu.cn; Jianwei Zhu: jianweiz@sjtu.edu.cn
URL: https://www.biorxiv.org/content/10.1101/2021.09.24.461616v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Shanghai Jiao Tong University; Westlake University, China; University of Texas, medical Branch; Jecho Biopharmaceuticals Co.; China CDC; Zhengzhou University People's Hospital; Jecho Laboratories (Frederick, MD)
Keywords: SARS-CoV-2, monoclonal antibody, virus genomic variants, spike protein, mice, primates
Summary of Study: This report characterizes the therapeutic antibodies specific to the tip of spike against SARS-CoV-2 and suggests the potential of antibody treatment with 2G1 to bring clinical benefit to COVID-19 patients.
References: doi: 10.1101/2021.09.24.461616
Contact Info: Lei Han: lei.han@jechobio.com; Hua Jiang: hua.jiang@jecholabs.com; Yueqing Xie: jecholabs.com; Qiang Zhou: zhouqiang@westlake.edu.cn; Jianwei Zhu: jianweiz@sjtu.edu.cn
URL: https://www.biorxiv.org/content/10.1101/2021.09.24.461616v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published:
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Florida State University; University of Texas Medical Branch, Perelman School of Medicine; and others.
Keywords: SARS-CoV-2, respiratory viral challenge, immune response, pathology, primates
Summary of Study: SARS-CoV-2 infection of pigtail macaques recapitulates important features of COVID-19 and reveals new immune and viral dynamics and thus may serve as a useful animal model for studying pathogenesis and testing vaccines and therapeutics.
References: doi: 10.1101/2021.08.28.458047
Contact Info: Nicholas Maness: nmaness@tulane.edu
URL: https://www.biorxiv.org/content/10.1101/2021.08.28.458047v1
NHP Species: pigtail macaques
Year Published:
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Florida State University; University of Texas Medical Branch, Perelman School of Medicine; and others.
Keywords: SARS-CoV-2, respiratory viral challenge, immune response, pathology, primates
Summary of Study: SARS-CoV-2 infection of pigtail macaques recapitulates important features of COVID-19 and reveals new immune and viral dynamics and thus may serve as a useful animal model for studying pathogenesis and testing vaccines and therapeutics.
References: doi: 10.1101/2021.08.28.458047
Contact Info: Nicholas Maness: nmaness@tulane.edu
URL: https://www.biorxiv.org/content/10.1101/2021.08.28.458047v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre, The Netherlands; Amsterdam UMC; Utrecht University, and others
Keywords: SARS-CoV-2, brain inflammation, longitudinal positron emission tomography, neuropathology,primates
Summary of Study: SARS-CoV-2 causes brain inflammation and Lewy bodies, a hallmark for Parkinson, after an asymptomatic infection in macaques.
References: doi: 10.1101/2021.02.23.432474
Contact Info: Ingrid Philippens: philippens@bprc.nl
URL: https://www.biorxiv.org/content/10.1101/2021.02.23.432474v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre, The Netherlands; Amsterdam UMC; Utrecht University, and others
Keywords: SARS-CoV-2, brain inflammation, longitudinal positron emission tomography, neuropathology,primates
Summary of Study: SARS-CoV-2 causes brain inflammation and Lewy bodies, a hallmark for Parkinson, after an asymptomatic infection in macaques.
References: doi: 10.1101/2021.02.23.432474
Contact Info: Ingrid Philippens: philippens@bprc.nl
URL: https://www.biorxiv.org/content/10.1101/2021.02.23.432474v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: CureVac AG; Ragon Institute of MGH, MIT and Harvard; Harvard Medical School
Keywords: SARS-CoV-2, mRNA vaccine, immunogenicity and protective efficacy, immune response, primates
Summary of Study: Optimization of non-coding regions can greatly improve the immunogenicity and protective efficacy of a non-modified mRNA SARS-CoV-2 vaccine in macaques. Improved characteristics of CV2CoV, compared with CVnCoV, may translate into increased efficacy in humans, and clinical trials of CV2C0V are planned.
References: doi: 10.1038/s41586-021-04231-6
Contact Info: Susanne Rauch: susanne.rauch@curevac.com; Daniel Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.nature.com/articles/s41586-021-04231-6
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: CureVac AG; Ragon Institute of MGH, MIT and Harvard; Harvard Medical School
Keywords: SARS-CoV-2, mRNA vaccine, immunogenicity and protective efficacy, immune response, primates
Summary of Study: Optimization of non-coding regions can greatly improve the immunogenicity and protective efficacy of a non-modified mRNA SARS-CoV-2 vaccine in macaques. Improved characteristics of CV2CoV, compared with CVnCoV, may translate into increased efficacy in humans, and clinical trials of CV2C0V are planned.
References: doi: 10.1038/s41586-021-04231-6
Contact Info: Susanne Rauch: susanne.rauch@curevac.com; Daniel Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.nature.com/articles/s41586-021-04231-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre (BPRC), Rijswijk, The Netherlands
Keywords: SARS-CoV-2, post-acute phase, pulmonary disease, primates
Summary of Study: Study provides a detailed description of the pathogenesis of a low-passage SARS-CoV-2 isolate in two macaque species (rhesus and cynomolgus) and suggests both species represent an equally good model for COVID-19 prophylactic and therapeutic treatments.
References: doi: https://doi.org/10.1101/2020.11.05.369413
Contact Info: Ernst. J. Verschoor: verschoor@bprc.nl
URL: https://www.biorxiv.org/content/10.1101/2020.11.05.369413v2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre (BPRC), Rijswijk, The Netherlands
Keywords: SARS-CoV-2, post-acute phase, pulmonary disease, primates
Summary of Study: Study provides a detailed description of the pathogenesis of a low-passage SARS-CoV-2 isolate in two macaque species (rhesus and cynomolgus) and suggests both species represent an equally good model for COVID-19 prophylactic and therapeutic treatments.
References: doi: https://doi.org/10.1101/2020.11.05.369413
Contact Info: Ernst. J. Verschoor: verschoor@bprc.nl
URL: https://www.biorxiv.org/content/10.1101/2020.11.05.369413v2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Tulane NPRC, Yerkes NPRC, New Iberia Research Center, Stanford
Keywords: SARS-CoV-2, subunit nanoparticle vaccine, primates
Summary of Study: These data reveal the promising performance of several adjuvants including AS03 and CpG 1018 (with Alum), which have been used in licensed vaccines, when used in conjunction with the SARS-CoV-2 RBD-NP immunogen.
References: PMID: 33594366 / doi: 10.1101/2021.02.10.430696
Contact Info: Bali Pulendran: bpulend@stanford.edu
URL: https://www.biorxiv.org/content/10.1101/2021.02.10.430696v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Tulane NPRC, Yerkes NPRC, New Iberia Research Center, Stanford
Keywords: SARS-CoV-2, subunit nanoparticle vaccine, primates
Summary of Study: These data reveal the promising performance of several adjuvants including AS03 and CpG 1018 (with Alum), which have been used in licensed vaccines, when used in conjunction with the SARS-CoV-2 RBD-NP immunogen.
References: PMID: 33594366 / doi: 10.1101/2021.02.10.430696
Contact Info: Bali Pulendran: bpulend@stanford.edu
URL: https://www.biorxiv.org/content/10.1101/2021.02.10.430696v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: California National Primate Research Center; School of Medicine, UC Davis; Vitalant Research Institute; University of Colorado School of Medicine; University of California, Irvine; and others.
Keywords: SARS-CoV-2, convalescent plasma, intratracheal and intranasal routes, pathology, primates
Summary of Study: While administration of convalescent plasma (CCP) did not result in a detectable reduction in virus replication in the respiratory tract, it significantly reduced lung inflammation.
References: doi: 10.1101/2021.09.01.458520
Contact Info: Koen Van Rompay: kkvanrompay@ucdavis.edu; Michael Busch: mbusch@vitalant.org; J. Rachel Reader: rreader@ucdavis.edu
URL: https://www.biorxiv.org/content/10.1101/2021.09.01.458520v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: California National Primate Research Center; School of Medicine, UC Davis; Vitalant Research Institute; University of Colorado School of Medicine; University of California, Irvine; and others.
Keywords: SARS-CoV-2, convalescent plasma, intratracheal and intranasal routes, pathology, primates
Summary of Study: While administration of convalescent plasma (CCP) did not result in a detectable reduction in virus replication in the respiratory tract, it significantly reduced lung inflammation.
References: doi: 10.1101/2021.09.01.458520
Contact Info: Koen Van Rompay: kkvanrompay@ucdavis.edu; Michael Busch: mbusch@vitalant.org; J. Rachel Reader: rreader@ucdavis.edu
URL: https://www.biorxiv.org/content/10.1101/2021.09.01.458520v1