Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: ImmunityBio, NantK west, Inc., IosBio
Keywords: SARS-CoV-2, hAd5 S-Fusion + N-ETSD vaccine, efficacy, primates
Summary of Study: NHP immunized with the hAd5 S-Fusion + N-ETSD vaccine generated anti-S IgG and showed inhibition in cPass and thus the presence of anti-S RBD neutralizing antibodies (nAbs).
References: doi: 10.1101/2020.12.08.416297
Contact Info: Patrick Soon-Shiong: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.12.08.416297v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: ImmunityBio, NantK west, Inc., IosBio
Keywords: SARS-CoV-2, hAd5 S-Fusion + N-ETSD vaccine, efficacy, primates
Summary of Study: NHP immunized with the hAd5 S-Fusion + N-ETSD vaccine generated anti-S IgG and showed inhibition in cPass and thus the presence of anti-S RBD neutralizing antibodies (nAbs).
References: doi: 10.1101/2020.12.08.416297
Contact Info: Patrick Soon-Shiong: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.12.08.416297v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Duke University, NIAID, 3 M Company
Keywords: SARS-CoV-2, receptor binding domain nanoparticle, vaccination, immune response, primates
Summary of Study: An RBD-scNP vaccine induced robust protective immunity for SARS-CoV-2 replication in the upper and lower respiratory tract. This vaccine represents a platform for producing a pancoronavirus vaccine that could prevent, rapidly temper, or extinguish the next spillover of a coronavirus into humans.
References: doi: 10.1101/2021.02.17.431492
Contact Info: Kevin Saunders: [email protected]; Barton Haynes: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.02.17.431492v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Duke University, NIAID, 3 M Company
Keywords: SARS-CoV-2, receptor binding domain nanoparticle, vaccination, immune response, primates
Summary of Study: An RBD-scNP vaccine induced robust protective immunity for SARS-CoV-2 replication in the upper and lower respiratory tract. This vaccine represents a platform for producing a pancoronavirus vaccine that could prevent, rapidly temper, or extinguish the next spillover of a coronavirus into humans.
References: doi: 10.1101/2021.02.17.431492
Contact Info: Kevin Saunders: [email protected]; Barton Haynes: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.02.17.431492v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: Duke University School of Medicine
Keywords: SARS-CoV-2, neutralizing and infection-enhancing antibodies, mice and primates
Summary of Study: SARS-CoV-2 antibodies can mediate infection enhancement in vitro. However, this in vitro phenotype does not translate to enhanced infection in a non-human primate model of SARS-CoV-2 infection. These preclinical results indicate that SARS-CoV-2 antibody treatments or the induction of SARS-CoV-2 antibodies by vaccination have a low likelihood of exacerbating COVID-19 disease in humans.
References: doi: https://doi.org/10.1101/2020.12.31.424729
Contact Info: Barton Haynes: [email protected]/Kevin Saunders: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.12.31.424729v2
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: Duke University School of Medicine
Keywords: SARS-CoV-2, neutralizing and infection-enhancing antibodies, mice and primates
Summary of Study: SARS-CoV-2 antibodies can mediate infection enhancement in vitro. However, this in vitro phenotype does not translate to enhanced infection in a non-human primate model of SARS-CoV-2 infection. These preclinical results indicate that SARS-CoV-2 antibody treatments or the induction of SARS-CoV-2 antibodies by vaccination have a low likelihood of exacerbating COVID-19 disease in humans.
References: doi: https://doi.org/10.1101/2020.12.31.424729
Contact Info: Barton Haynes: [email protected]/Kevin Saunders: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.12.31.424729v2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID, Emory University, Moderna
Keywords: SARS-CoV-2, mRNA vaccine, immune response, pathology, primates
Summary of Study: Immunization with two doses of mRNA-1273 achieves effective immunity that rapidly controls lower and upper airway viral replication against the B.1.351 variant in NHP.
References: doi: 10.1101/2021.05.21.445189
Contact Info: Barney Graham: [email protected]; Robert Seder: [email protected];
URL: https://www.biorxiv.org/content/10.1101/2021.05.21.445189v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID, Emory University, Moderna
Keywords: SARS-CoV-2, mRNA vaccine, immune response, pathology, primates
Summary of Study: Immunization with two doses of mRNA-1273 achieves effective immunity that rapidly controls lower and upper airway viral replication against the B.1.351 variant in NHP.
References: doi: 10.1101/2021.05.21.445189
Contact Info: Barney Graham: [email protected]; Robert Seder: [email protected];
URL: https://www.biorxiv.org/content/10.1101/2021.05.21.445189v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published:
Study Type/Review:
NPRC/Institute: University of TX Medical Branch
Keywords: SARS-CoV-2, convalescent sera, primates, viral load and disease pathology
Summary of Study: Groups of SARS-CoV-2 infected AGMs were treated with pooled convalescent sera containing either high or low to moderate anti-SARS-CoV-2 neutralizing antibody titers. Lower levels of SARS-CoV-2 in respiratory compartments, reduced gross and histopathological lesion severity in the lungs, and reductions in several parameters associated with coagulation and inflammatory processes were observed in monkeys that received convalescent sera versus untreated controls.
References: doi: https://doi.org/10.1101/2020.10.14.340091
Contact Info: Thomas Geisbert: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.10.14.340091v1
NHP Species: african green monkeys
Year Published:
Study Type/Review:
NPRC/Institute: University of TX Medical Branch
Keywords: SARS-CoV-2, convalescent sera, primates, viral load and disease pathology
Summary of Study: Groups of SARS-CoV-2 infected AGMs were treated with pooled convalescent sera containing either high or low to moderate anti-SARS-CoV-2 neutralizing antibody titers. Lower levels of SARS-CoV-2 in respiratory compartments, reduced gross and histopathological lesion severity in the lungs, and reductions in several parameters associated with coagulation and inflammatory processes were observed in monkeys that received convalescent sera versus untreated controls.
References: doi: https://doi.org/10.1101/2020.10.14.340091
Contact Info: Thomas Geisbert: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.10.14.340091v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: CureVac AG Tuebingen, Germany
Keywords: SARS-CoV-2, mRNA vaccine CVnCoV, safety, immunogenicity, and protective efficacy, primates
Summary of Study: The efficacy of CVnCoV, a lipid-nanoparticle encapsulated, sequence optimized mRNA-based SARS-CoV-2 vaccine was evaluated. The study demonstrates that CVnCoV induces robust humoral and cellular responses in non-human primates. These results demonstrate safety, immunogenicity, and protective efficacy of this vaccine that extend beyond previously published preclinical data and provide strong support for further clinical testing in ongoing phase 2b/3 efficacy studies.
References: doi: https://doi.org/10.1101/2020.12.23.424138
Contact Info: no contact information provided
URL: https://www.biorxiv.org/content/10.1101/2020.12.23.424138v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: CureVac AG Tuebingen, Germany
Keywords: SARS-CoV-2, mRNA vaccine CVnCoV, safety, immunogenicity, and protective efficacy, primates
Summary of Study: The efficacy of CVnCoV, a lipid-nanoparticle encapsulated, sequence optimized mRNA-based SARS-CoV-2 vaccine was evaluated. The study demonstrates that CVnCoV induces robust humoral and cellular responses in non-human primates. These results demonstrate safety, immunogenicity, and protective efficacy of this vaccine that extend beyond previously published preclinical data and provide strong support for further clinical testing in ongoing phase 2b/3 efficacy studies.
References: doi: https://doi.org/10.1101/2020.12.23.424138
Contact Info: no contact information provided
URL: https://www.biorxiv.org/content/10.1101/2020.12.23.424138v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: ImmunityBio, Culver City, CA
Keywords: SARS-CoV-2, prime and oral boost bivalent hAd5 vaccination, T-cell response, primates
Summary of Study: Treatment with bivalent hAd5S-Fusion + N-ETSD subcutaneous and oral vaccine provided complete protection of nasal and lung airways against SARS-CoV-2 challenge in rhesus macaques. Data demonstrate that all NHPs immunized with the hAD5 S-Fusion + N-ETSD vaccine generated anti-S IgG and that 9 of 10 animals showed inhibition in cPass (TM) and thus the presence of anti-S RBD neutralizing antibodies.
References: doi: https://doi.org/10.1101/2020.12.08.416297
Contact Info: Patrick Soon-Shiong: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.12.08.416297v3
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: ImmunityBio, Culver City, CA
Keywords: SARS-CoV-2, prime and oral boost bivalent hAd5 vaccination, T-cell response, primates
Summary of Study: Treatment with bivalent hAd5S-Fusion + N-ETSD subcutaneous and oral vaccine provided complete protection of nasal and lung airways against SARS-CoV-2 challenge in rhesus macaques. Data demonstrate that all NHPs immunized with the hAD5 S-Fusion + N-ETSD vaccine generated anti-S IgG and that 9 of 10 animals showed inhibition in cPass (TM) and thus the presence of anti-S RBD neutralizing antibodies.
References: doi: https://doi.org/10.1101/2020.12.08.416297
Contact Info: Patrick Soon-Shiong: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.12.08.416297v3
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Duke Human Vaccine Institute
Keywords: SARS-CoV-2, multimeric receptor binding domain nanoparticle, cross-neutralizing antibody, virus variants, primates
Summary of Study: This study demonstrates the ability of a SARS-CoV-2 RBD 24-mer subunit nanoparticle vaccine to elicit potent cross-neutralizing antibodies against SARS-CoV-1, SARS-CoV-2, SARS-CoV-2 variant B.1.1.7. as well as SARS-related bat betaCoVs.
References: PMID: 33619494 / doi: 10.1101/2021.02.17.431492
Contact Info: Kevin Saunders: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.02.17.431492v1
NHP Species: multiple species
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Duke Human Vaccine Institute
Keywords: SARS-CoV-2, multimeric receptor binding domain nanoparticle, cross-neutralizing antibody, virus variants, primates
Summary of Study: This study demonstrates the ability of a SARS-CoV-2 RBD 24-mer subunit nanoparticle vaccine to elicit potent cross-neutralizing antibodies against SARS-CoV-1, SARS-CoV-2, SARS-CoV-2 variant B.1.1.7. as well as SARS-related bat betaCoVs.
References: PMID: 33619494 / doi: 10.1101/2021.02.17.431492
Contact Info: Kevin Saunders: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.02.17.431492v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences
Keywords: SARS-CoV-2, interferon (IFN)-armed receptor-binding domain, immune response, primates
Summary of Study: The pan-epitope modified human I-R-F (I-P-R-F) vaccine provides rapid and complete protection throughout the upper and lower respiratory tracts against a high-dose SARS-CoV-2 challenge in rhesus macaques.
References: doi: 10.1038/s41422-021-00531-8
Contact Info: Hua Peng: https://www.nature.com/articles/s41422-021-00531-8/email/correspondent/c3/new
URL: https://www.nature.com/articles/s41422-021-00531-8
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences
Keywords: SARS-CoV-2, interferon (IFN)-armed receptor-binding domain, immune response, primates
Summary of Study: The pan-epitope modified human I-R-F (I-P-R-F) vaccine provides rapid and complete protection throughout the upper and lower respiratory tracts against a high-dose SARS-CoV-2 challenge in rhesus macaques.
References: doi: 10.1038/s41422-021-00531-8
Contact Info: Hua Peng: https://www.nature.com/articles/s41422-021-00531-8/email/correspondent/c3/new
URL: https://www.nature.com/articles/s41422-021-00531-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: University of Pennsylvania
Keywords: SARS-CoV-2, vaccine, pseudovirus, neutralizing antibodies, mice, primates, humans
Summary of Study: SARs-CoV-2 recently mutated near the region targeted by many vaccines. The current study tested whether the mutation would hinder the ability of current vaccines to induce neutralizing antibodies in mice/NHPs/human serum. Their results indicate the viral mutation will not interfere with the effects of vaccines developed based on the original protein structure.
References: doi: 10.1101/2020.07.22.20159905
Contact Info: Drew Weissman, Email: [email protected] OR Davis Montefiori, email: [email protected]
URL: https://www.medrxiv.org/content/10.1101/2020.07.22.20159905v2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: University of Pennsylvania
Keywords: SARS-CoV-2, vaccine, pseudovirus, neutralizing antibodies, mice, primates, humans
Summary of Study: SARs-CoV-2 recently mutated near the region targeted by many vaccines. The current study tested whether the mutation would hinder the ability of current vaccines to induce neutralizing antibodies in mice/NHPs/human serum. Their results indicate the viral mutation will not interfere with the effects of vaccines developed based on the original protein structure.
References: doi: 10.1101/2020.07.22.20159905
Contact Info: Drew Weissman, Email: [email protected] OR Davis Montefiori, email: [email protected]
URL: https://www.medrxiv.org/content/10.1101/2020.07.22.20159905v2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: BioNTech, Mainz, Germany
Keywords: SARS-CoV-2, BNT162b vaccine, primates
Summary of Study: Prime/boost vaccination of rhesus macaques with BNT162b candidates protect macaques from SARS-CoV-2 challenge. Both candidates are being evaluated in phase 1 trials in Germany and the US.
References: doi: https://doi.org/10.1101/2020.12.11.421008
Contact Info: Ugur Sahin: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.12.11.421008v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: BioNTech, Mainz, Germany
Keywords: SARS-CoV-2, BNT162b vaccine, primates
Summary of Study: Prime/boost vaccination of rhesus macaques with BNT162b candidates protect macaques from SARS-CoV-2 challenge. Both candidates are being evaluated in phase 1 trials in Germany and the US.
References: doi: https://doi.org/10.1101/2020.12.11.421008
Contact Info: Ugur Sahin: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.12.11.421008v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID, Emory University
Keywords: SARS-CoV-2, mRNA vaccine, virus genome variants, immune response, pathology, primates
Summary of Study: Immunization with two doses of mRNA-1273 achieves effective immunity that rapidly controls lower and upper airway viral replication against the B-1.351 variant in NHP.
References: PMID: 34075375 / doi: 10.1101/2021.05.21.445189
Contact Info: Barney Graham: [email protected]; Robert Seder: [email protected];
URL: https://www.biorxiv.org/content/10.1101/2021.05.21.445189v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID, Emory University
Keywords: SARS-CoV-2, mRNA vaccine, virus genome variants, immune response, pathology, primates
Summary of Study: Immunization with two doses of mRNA-1273 achieves effective immunity that rapidly controls lower and upper airway viral replication against the B-1.351 variant in NHP.
References: PMID: 34075375 / doi: 10.1101/2021.05.21.445189
Contact Info: Barney Graham: [email protected]; Robert Seder: [email protected];
URL: https://www.biorxiv.org/content/10.1101/2021.05.21.445189v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Eli Lilly & Co.; NIAID
Keywords: SARS-CoV-2, anti-spike neutralizing antibodies, primate challenge model
Summary of Study: Prophylactic treatment with LY-CoV555 (a neutralizing antibody) resulted in significant decreases in viral load (gRNA) and viral replication (sgRNA) in the lower respiratory tract of rhesus macaques following SARS-CoV2 inoculation, based on determination in BAL and lung tissue.
References: doi:Â https://doi.org/10.1101/2020.09.30.318972
Contact Info: Bryan Jones: [email protected]; Ester Falconer: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.09.30.318972v3
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Eli Lilly & Co.; NIAID
Keywords: SARS-CoV-2, anti-spike neutralizing antibodies, primate challenge model
Summary of Study: Prophylactic treatment with LY-CoV555 (a neutralizing antibody) resulted in significant decreases in viral load (gRNA) and viral replication (sgRNA) in the lower respiratory tract of rhesus macaques following SARS-CoV2 inoculation, based on determination in BAL and lung tissue.
References: doi:Â https://doi.org/10.1101/2020.09.30.318972
Contact Info: Bryan Jones: [email protected]; Ester Falconer: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.09.30.318972v3
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Harvard Medical School
Keywords: SARS-CoV-2, Multiplexed proteomics and imaging, acute respiratory distress, primates
Summary of Study: The data in this paper highlight the ability of proteomics, imaging, and spatial transcriptomics of the same specimens to trace successive steps in diverse regulatory cascades. This approach is applicable to any fixed tissue. No other approach involving readily available histological specimens provides a similarly integrated picture of a disease process.
References: doi: https://doi.org/10.1101/2020.10.14.339952
Contact Info: Marian Kalocsay: [email protected]; Peter Sorger: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.10.14.339952v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Harvard Medical School
Keywords: SARS-CoV-2, Multiplexed proteomics and imaging, acute respiratory distress, primates
Summary of Study: The data in this paper highlight the ability of proteomics, imaging, and spatial transcriptomics of the same specimens to trace successive steps in diverse regulatory cascades. This approach is applicable to any fixed tissue. No other approach involving readily available histological specimens provides a similarly integrated picture of a disease process.
References: doi: https://doi.org/10.1101/2020.10.14.339952
Contact Info: Marian Kalocsay: [email protected]; Peter Sorger: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.10.14.339952v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School
Keywords: SARS-CoV-2, AAV-based, single dose vaccine, primates
Summary of Study: Two adeno-associated viral (AAV)-based vaccine candidates demonstrate potent immunogenicity in mouse and NHP models following a single injection. Moreover, the vaccine is stable at room temperature for a least one month and is produced at high yields using established commercial manufacturing processes in the gene therapy industry.
References: doi: https://doi.org/10.1101/2021.01.05.422952
Contact Info: Luk Vandenberghe: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.01.05.422952v3
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School
Keywords: SARS-CoV-2, AAV-based, single dose vaccine, primates
Summary of Study: Two adeno-associated viral (AAV)-based vaccine candidates demonstrate potent immunogenicity in mouse and NHP models following a single injection. Moreover, the vaccine is stable at room temperature for a least one month and is produced at high yields using established commercial manufacturing processes in the gene therapy industry.
References: doi: https://doi.org/10.1101/2021.01.05.422952
Contact Info: Luk Vandenberghe: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.01.05.422952v3
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Intuitive Biosciences
Keywords: SARS-CoV-2, spike binding antibodies with neutralizing activity, immunization, primates
Summary of Study: Efficacy of vaccine candidates based on the SARS-CoV-2 spike was assessed in cynomolgus macaques by examining their ability to generate spike binding antibodies with neutralizing activity. Neutralizing activity persisted for more than 20 weeks. These data support the utility of spike subunit-based antigens as a vaccine for use in humans.
References: PMID: 33398285/doi: 10.1101/2020.12.20.422693
Contact Info: Kimberly Luke (no contact information)
URL: https://www.biorxiv.org/content/10.1101/2020.12.20.422693v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Intuitive Biosciences
Keywords: SARS-CoV-2, spike binding antibodies with neutralizing activity, immunization, primates
Summary of Study: Efficacy of vaccine candidates based on the SARS-CoV-2 spike was assessed in cynomolgus macaques by examining their ability to generate spike binding antibodies with neutralizing activity. Neutralizing activity persisted for more than 20 weeks. These data support the utility of spike subunit-based antigens as a vaccine for use in humans.
References: PMID: 33398285/doi: 10.1101/2020.12.20.422693
Contact Info: Kimberly Luke (no contact information)
URL: https://www.biorxiv.org/content/10.1101/2020.12.20.422693v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: University of Oxford
Keywords: SARS-CoV-2, protein nanoparticle vaccine, primates
Summary of Study: Ferrets and rhesus macaques were challenged with SARCS-CoV-2 to assess the potential for vaccine-enhanced disease (VED) in animals vaccinated with formaldehyde-inactivated SARS-CoV-2 formulated with Alhydrogel. This study revealed no evidence of enhanced disease in rhesus macaques.
References: doi: https://doi.org/10.1101/2020.12.21.423746
Contact Info: Andrew Gorringe: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.12.21.423746v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: University of Oxford
Keywords: SARS-CoV-2, protein nanoparticle vaccine, primates
Summary of Study: Ferrets and rhesus macaques were challenged with SARCS-CoV-2 to assess the potential for vaccine-enhanced disease (VED) in animals vaccinated with formaldehyde-inactivated SARS-CoV-2 formulated with Alhydrogel. This study revealed no evidence of enhanced disease in rhesus macaques.
References: doi: https://doi.org/10.1101/2020.12.21.423746
Contact Info: Andrew Gorringe: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.12.21.423746v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Sanofi Pasteur, GSK
Keywords: SARS-CoV-2, virus genomic variants, vaccine boosters, immune response, primates
Summary of Study: One booster dose of AS03-adjuvanted CoV2 preS dTM, D614 (parental) or B.1.351 (Beta), in monovalent of bivalent formulations, significantly booster pre-existing neutralizing antibodies and elicited high and stable cross-neutralizing antibodies covering the four known SARS-CV-2 variants of concern.
References: doi: 10.1101/2021.09.20.461023
Contact Info: Valerie Lecouturier: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.09.20.461023v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Sanofi Pasteur, GSK
Keywords: SARS-CoV-2, virus genomic variants, vaccine boosters, immune response, primates
Summary of Study: One booster dose of AS03-adjuvanted CoV2 preS dTM, D614 (parental) or B.1.351 (Beta), in monovalent of bivalent formulations, significantly booster pre-existing neutralizing antibodies and elicited high and stable cross-neutralizing antibodies covering the four known SARS-CV-2 variants of concern.
References: doi: 10.1101/2021.09.20.461023
Contact Info: Valerie Lecouturier: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.09.20.461023v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: University of Bern
Keywords: SARS-CoV-2, airway epithelial cell (AEC) culture repository, multiple animal species
Summary of Study: Well-differentiated primary airway epithelial cell cultures were established from various domestic and wildlife animal species (including rhesus macaques) to assess the potential intermediate and spillback host reservoir spectrum of SARS-CoV-2. rhesus macaque post-mortem tracheobronchial airway tissue material. These were inoculated with SARS-CoV-2/Munchen-1.1/2020/929 isolate and monitored for viral titer for 96 hours. Infectious progeny virus were absent in most species, except rhesus macaques and cats, indicating that some species are not ideally suited as animal models in studies of SARS-CoV-2.
References: doi: https://doi.org/10.1101/2020.11.10.374587
Contact Info: Ronald Dijkman: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.11.10.374587v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: University of Bern
Keywords: SARS-CoV-2, airway epithelial cell (AEC) culture repository, multiple animal species
Summary of Study: Well-differentiated primary airway epithelial cell cultures were established from various domestic and wildlife animal species (including rhesus macaques) to assess the potential intermediate and spillback host reservoir spectrum of SARS-CoV-2. rhesus macaque post-mortem tracheobronchial airway tissue material. These were inoculated with SARS-CoV-2/Munchen-1.1/2020/929 isolate and monitored for viral titer for 96 hours. Infectious progeny virus were absent in most species, except rhesus macaques and cats, indicating that some species are not ideally suited as animal models in studies of SARS-CoV-2.
References: doi: https://doi.org/10.1101/2020.11.10.374587
Contact Info: Ronald Dijkman: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.11.10.374587v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID; CureVac AG
Keywords: SARS-CoV-2, mRNA vaccine, immune response, primates
Summary of Study: Prime-boost vaccination with 4 ug of vaccine candidate CV07050101 resulted in limited immune responses in 4 out of 6 non-human primates.
References: doi: 10.1101/2021.07.07.451505
Contact Info: Vincent Munster: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.07.07.451505v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID; CureVac AG
Keywords: SARS-CoV-2, mRNA vaccine, immune response, primates
Summary of Study: Prime-boost vaccination with 4 ug of vaccine candidate CV07050101 resulted in limited immune responses in 4 out of 6 non-human primates.
References: doi: 10.1101/2021.07.07.451505
Contact Info: Vincent Munster: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.07.07.451505v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: SWNPRC/BioNtech
Keywords: SARS-CoV-2, RNA vaccine, immune response, mice, primates
Summary of Study: This study challenged immunization with the BNT162b2 vaccine candidate containing mRNA encoding for the spike glycoprotein in mice and monkeys. Immunization in mice induced a strong immune response and immunization in monkeys fully protected the animal's lungs from SARS-CoV-2 infection.
References: doi: 10.1101/2020.09.08.280818
Contact Info: Ugur Sahin; Email: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.09.08.280818v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: SWNPRC/BioNtech
Keywords: SARS-CoV-2, RNA vaccine, immune response, mice, primates
Summary of Study: This study challenged immunization with the BNT162b2 vaccine candidate containing mRNA encoding for the spike glycoprotein in mice and monkeys. Immunization in mice induced a strong immune response and immunization in monkeys fully protected the animal's lungs from SARS-CoV-2 infection.
References: doi: 10.1101/2020.09.08.280818
Contact Info: Ugur Sahin; Email: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.09.08.280818v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: CNPRC/Vitalant
Keywords: SARS-CoV-2, protective immunity, CD4 helper cells, primates
Summary of Study: vaccine promoting Th1-type Tfh responses that target the S protein may lead to protective immunity
References: doi: 10.1101/2020.07.07.191007
Contact Info: Sonny Elizaldi, UC Davis CIID
URL: https://www.biorxiv.org/content/10.1101/2020.07.07.191007v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: CNPRC/Vitalant
Keywords: SARS-CoV-2, protective immunity, CD4 helper cells, primates
Summary of Study: vaccine promoting Th1-type Tfh responses that target the S protein may lead to protective immunity
References: doi: 10.1101/2020.07.07.191007
Contact Info: Sonny Elizaldi, UC Davis CIID
URL: https://www.biorxiv.org/content/10.1101/2020.07.07.191007v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Sanofi Pasteur
Keywords: SARS-CoV-2, mRNA vaccine candidates, primates
Summary of Study: Several mRNA constructs expressing various structural conformations of S-protein were tested in cynomolgus macaques for their capacity to elicit neutralizing antibodies. The candidate MRT5500 was shown to be immunogenic by eliciting potent neutralizing antibodies in both mice and cynomolgus macaques and is position for further development in clinical studies as a vaccine for the prevention of COVID-19.
References: doi: https://doi.org/10.1101/2020.10.14.337535
Contact Info: none listed
URL: https://www.biorxiv.org/content/10.1101/2020.10.14.337535v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Sanofi Pasteur
Keywords: SARS-CoV-2, mRNA vaccine candidates, primates
Summary of Study: Several mRNA constructs expressing various structural conformations of S-protein were tested in cynomolgus macaques for their capacity to elicit neutralizing antibodies. The candidate MRT5500 was shown to be immunogenic by eliciting potent neutralizing antibodies in both mice and cynomolgus macaques and is position for further development in clinical studies as a vaccine for the prevention of COVID-19.
References: doi: https://doi.org/10.1101/2020.10.14.337535
Contact Info: none listed
URL: https://www.biorxiv.org/content/10.1101/2020.10.14.337535v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Tulane NPRC
Keywords: SARS-CoV-2, immune response, primates
Summary of Study: Increased levels of monocytes and chemokines after infection is associated with viral load and disease severity
References: doi: https://doi.org/10.1101/2020.07.21.213777
Contact Info: Monica Vaccari, [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.07.21.213777v1%20
NHP Species: african green monkeys, rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Tulane NPRC
Keywords: SARS-CoV-2, immune response, primates
Summary of Study: Increased levels of monocytes and chemokines after infection is associated with viral load and disease severity
References: doi: https://doi.org/10.1101/2020.07.21.213777
Contact Info: Monica Vaccari, [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.07.21.213777v1%20
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: ONPRC/YNPRC
Keywords: SARS-CoV-2, kinase inhibitor, primates
Summary of Study: Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques
References: doi: https://doi.org/10.1101/2020.09.16.300277
Contact Info: Dr. Mirko Paiardini; E-mail address: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.09.16.300277v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: ONPRC/YNPRC
Keywords: SARS-CoV-2, kinase inhibitor, primates
Summary of Study: Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques
References: doi: https://doi.org/10.1101/2020.09.16.300277
Contact Info: Dr. Mirko Paiardini; E-mail address: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.09.16.300277v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: NIAID/NIH
Keywords: SARS-CoV-2, virus variants, pathogenicity, immune response, primates
Summary of Study: A side-by-side comparison of three SARS-CoV-2 variants suggests that ongoing circulation under diverse evolutionary pressures favors transmissibility and immune evasion rather than an increase in intrinsic pathogenicity.
References: PMID: 34382034 / doi: 10.1101/2021.05.07.443115
Contact Info: Emmie de Wit: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.05.07.443115v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: NIAID/NIH
Keywords: SARS-CoV-2, virus variants, pathogenicity, immune response, primates
Summary of Study: A side-by-side comparison of three SARS-CoV-2 variants suggests that ongoing circulation under diverse evolutionary pressures favors transmissibility and immune evasion rather than an increase in intrinsic pathogenicity.
References: PMID: 34382034 / doi: 10.1101/2021.05.07.443115
Contact Info: Emmie de Wit: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.05.07.443115v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: University of Liverpool; NIHR Health Protection Unit in Emerging and Zoonotic Infections; University of Bristol; IK Health Security Agency; Mahidol University; Alder Hey Children's Hospital; Imperial College London; The Roslin Institute, University of Edinburgh; Royal United Hospitals Bath NHS Foundation Trust; University of Oxford; A*STAR, Singapore.
Keywords: SARS-CoV-2, viral genomic variants, variant prediction, primates
Summary of Study: The selection pressure at two positions (the P323L and the D614G substitutions in the in NSP12 and the spike protein, respectively) was evaluated in two non-human primate models. The data in this study indicates that in some cases it may be possible to predict the emergence of a new dominant viral genome sequence and hence a new variant.
References: doi: 10.1101/2021.12.23.474030
Contact Info: Julian Hiscox: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.12.23.474030v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: University of Liverpool; NIHR Health Protection Unit in Emerging and Zoonotic Infections; University of Bristol; IK Health Security Agency; Mahidol University; Alder Hey Children's Hospital; Imperial College London; The Roslin Institute, University of Edinburgh; Royal United Hospitals Bath NHS Foundation Trust; University of Oxford; A*STAR, Singapore.
Keywords: SARS-CoV-2, viral genomic variants, variant prediction, primates
Summary of Study: The selection pressure at two positions (the P323L and the D614G substitutions in the in NSP12 and the spike protein, respectively) was evaluated in two non-human primate models. The data in this study indicates that in some cases it may be possible to predict the emergence of a new dominant viral genome sequence and hence a new variant.
References: doi: 10.1101/2021.12.23.474030
Contact Info: Julian Hiscox: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.12.23.474030v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: NIAID; La Jolla Institute for Immunology; University of California; University of Capetown
Keywords: SARS-CoV-2, viral replication, pathogenesis. Immune response, primates
Summary of Study: SARS-CoV-2 infection leads to mild, focal lung inflammation, and type 1 IFN activated myeloid cells that mostly resolve prior to the influx of virus-specific effector T cells or antibody responses in rhesus macaques.
References: doi: 10.1101/2022.01.06.475282
Contact Info: Daniel Barber: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.01.06.475282v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: NIAID; La Jolla Institute for Immunology; University of California; University of Capetown
Keywords: SARS-CoV-2, viral replication, pathogenesis. Immune response, primates
Summary of Study: SARS-CoV-2 infection leads to mild, focal lung inflammation, and type 1 IFN activated myeloid cells that mostly resolve prior to the influx of virus-specific effector T cells or antibody responses in rhesus macaques.
References: doi: 10.1101/2022.01.06.475282
Contact Info: Daniel Barber: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.01.06.475282v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: SUNY Upstate Medical University; Walter Reed Army Institute of Research; NIAID; Henry M. Jackson Foundation for the Advancement of Military Medicine
Keywords: SARS-CoV-2, mRNA-1273 vaccine, single-cell transcriptomic profiling, virus variants, inflammation, primates
Summary of Study: Single cell RNA sequencing analysis demonstrates that mRNA-1273 vaccination limits the development of lower respiratory tract inflammation in SARS-CoV-2 challenged rhesus macaques.
References: doi: 10.1101/2021.12.24.474132
Contact Info: Robert Seder: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.12.24.474132v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: SUNY Upstate Medical University; Walter Reed Army Institute of Research; NIAID; Henry M. Jackson Foundation for the Advancement of Military Medicine
Keywords: SARS-CoV-2, mRNA-1273 vaccine, single-cell transcriptomic profiling, virus variants, inflammation, primates
Summary of Study: Single cell RNA sequencing analysis demonstrates that mRNA-1273 vaccination limits the development of lower respiratory tract inflammation in SARS-CoV-2 challenged rhesus macaques.
References: doi: 10.1101/2021.12.24.474132
Contact Info: Robert Seder: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.12.24.474132v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Duke University School of Medicine; University of North Carolina at Chapel Hill; NIAID; Division of Viral Products, FDA; Beth Israel Deaconess Medical Center; University of Pennsylvania; Corporate Research Materials Lab, 3M Company; Infectious Disease Research Institute; BIOQUAL
Keywords: SARS-CoV-2, ferritin nanoparticle (RBD-scNP) vaccine, virus variants, immune response, primates
Summary of Study: Study demonstrates that scNP vaccines with SARS-CoV-2 spike or spike subunits confer potent protection in NHPs against WA-1, Beta and Delta variants, and that they induce neutralizing antibodies to all SARS-CoV-2 variants tested in vitro.
References: doi: 10.1101/2022.01.26.477915
Contact Info: Kevin Saunders: [email protected]; Barton Haynes: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.01.26.477915v2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Duke University School of Medicine; University of North Carolina at Chapel Hill; NIAID; Division of Viral Products, FDA; Beth Israel Deaconess Medical Center; University of Pennsylvania; Corporate Research Materials Lab, 3M Company; Infectious Disease Research Institute; BIOQUAL
Keywords: SARS-CoV-2, ferritin nanoparticle (RBD-scNP) vaccine, virus variants, immune response, primates
Summary of Study: Study demonstrates that scNP vaccines with SARS-CoV-2 spike or spike subunits confer potent protection in NHPs against WA-1, Beta and Delta variants, and that they induce neutralizing antibodies to all SARS-CoV-2 variants tested in vitro.
References: doi: 10.1101/2022.01.26.477915
Contact Info: Kevin Saunders: [email protected]; Barton Haynes: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.01.26.477915v2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Northwestern University Feinberg School of Medicine; Tulane National Primate Research Center; New Iberia Research Center
Keywords: SARS-CoV-2, male genital tract, positron emission tomography, pathogenesis, primates
Summary of Study: Results suggest that SARS-CoV-2 rapidly and efficiently infects multiple tissues of the male genital tract (MGT) early during infection in rhesus macaques.
References: PMID: 35262081 / doi: 10.1101/2022.02.25.481974
Contact Info: Thomas J. Hope: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.02.25.481974v2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Northwestern University Feinberg School of Medicine; Tulane National Primate Research Center; New Iberia Research Center
Keywords: SARS-CoV-2, male genital tract, positron emission tomography, pathogenesis, primates
Summary of Study: Results suggest that SARS-CoV-2 rapidly and efficiently infects multiple tissues of the male genital tract (MGT) early during infection in rhesus macaques.
References: PMID: 35262081 / doi: 10.1101/2022.02.25.481974
Contact Info: Thomas J. Hope: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.02.25.481974v2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: California Institute of Technology; NIAID, Fred Hutchinson Cancer Research Center; Bioqual; University of Oxford; Howard Hughes Medical Institute
Keywords: SARS-CoV-2, spike receptor-binding domains, mosaic nanoparticles, immunogenicity, mice, primates
Summary of Study: A mosaic RBD nanoparticle presenting 8 different sarbecovirus RBDs protected against challenges from both matched and mismatched sarbecoviruses, as compared with homotypic SARS-2 RBD nanoparticles that protected fully only against a matched challenge.
References: PMID: 35378752 / doi: 10.1101/2022.03.25.485875
Contact Info: Pamela Bjorkman: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.03.25.485875v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: California Institute of Technology; NIAID, Fred Hutchinson Cancer Research Center; Bioqual; University of Oxford; Howard Hughes Medical Institute
Keywords: SARS-CoV-2, spike receptor-binding domains, mosaic nanoparticles, immunogenicity, mice, primates
Summary of Study: A mosaic RBD nanoparticle presenting 8 different sarbecovirus RBDs protected against challenges from both matched and mismatched sarbecoviruses, as compared with homotypic SARS-2 RBD nanoparticles that protected fully only against a matched challenge.
References: PMID: 35378752 / doi: 10.1101/2022.03.25.485875
Contact Info: Pamela Bjorkman: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.03.25.485875v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID, Emory, OLAW,
Keywords: SARS-CoV-2, parainfluenza virus-vectored vaccine, pediatric, immune response, primates
Summary of Study: Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine candidate is protective in macaques
References: PMID: 35665011 PMCID: PMC9164439 DOI: 10.1101/2022.05.21.492923
Contact Info: Ursula J. Buchholz: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.05.21.492923v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID, Emory, OLAW,
Keywords: SARS-CoV-2, parainfluenza virus-vectored vaccine, pediatric, immune response, primates
Summary of Study: Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine candidate is protective in macaques
References: PMID: 35665011 PMCID: PMC9164439 DOI: 10.1101/2022.05.21.492923
Contact Info: Ursula J. Buchholz: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.05.21.492923v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: National Institute of Allergy and Infectious Diseases, National Institutes of Health
Keywords: SARS-CoV-2, virus variants, pathology, immune response, primates
Summary of Study: Disease severity among variants is unequal, with a lower viral load and thus reduced clinical disease in Omicron versus Delta variants.
References: PMID: 35971544 / doi: 10.1101/2022.08.01.502390
Contact Info: Neeltje van Doremalen: [email protected]; Kyle Rosenke: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.08.01.502390v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: National Institute of Allergy and Infectious Diseases, National Institutes of Health
Keywords: SARS-CoV-2, virus variants, pathology, immune response, primates
Summary of Study: Disease severity among variants is unequal, with a lower viral load and thus reduced clinical disease in Omicron versus Delta variants.
References: PMID: 35971544 / doi: 10.1101/2022.08.01.502390
Contact Info: Neeltje van Doremalen: [email protected]; Kyle Rosenke: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.08.01.502390v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: National Institute of Allergy and
Infectious Diseases, National Institutes of Health; Washington National Primate Research Center, University of Washington; HDT Bio; Fred Hutchinson Cancer Research Center
Keywords: SARS-CoV-2, replicon RNA vaccine, neutralizing antibody response, pathology, primates
Summary of Study: A self-amplifying replicon RNA vaccine elicits protective immunity to COVID-19 and a strong protective response even after antibody levels decreased to undetectable levels.
References: PMID: 35982677 / doi: 10.1101/2022.08.08.503239
Contact Info: Deborah Heydenburg Fuller; Jesse H. Erasmus
URL: https://www.biorxiv.org/content/10.1101/2022.08.08.503239v1
NHP Species: pigtail macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: National Institute of Allergy and
Infectious Diseases, National Institutes of Health; Washington National Primate Research Center, University of Washington; HDT Bio; Fred Hutchinson Cancer Research Center
Keywords: SARS-CoV-2, replicon RNA vaccine, neutralizing antibody response, pathology, primates
Summary of Study: A self-amplifying replicon RNA vaccine elicits protective immunity to COVID-19 and a strong protective response even after antibody levels decreased to undetectable levels.
References: PMID: 35982677 / doi: 10.1101/2022.08.08.503239
Contact Info: Deborah Heydenburg Fuller; Jesse H. Erasmus
URL: https://www.biorxiv.org/content/10.1101/2022.08.08.503239v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: National Institute of Allergy and Infectious Disease, NIH; University of California- Berkely; La Jolla Institute for Immunology; University of California - San Diego; University of Cape Town - Observatory
Keywords: SARS-CoV-2, IFN? and IL-10, immune response, viral replication, primates
Summary of Study: There are no major effects of the pro- and anti-inflammatory pathways in COVID-19 infection, but IL-10, an anti-inflammatory cytokine, has a role in suppressing the accumulation of T-cells specific to infection in the lower airways.
References: PMID: 36172119 / doi: 10.1101/2022.09.13.507852
Contact Info: Daniel Barber: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.09.13.507852v2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: National Institute of Allergy and Infectious Disease, NIH; University of California- Berkely; La Jolla Institute for Immunology; University of California - San Diego; University of Cape Town - Observatory
Keywords: SARS-CoV-2, IFN? and IL-10, immune response, viral replication, primates
Summary of Study: There are no major effects of the pro- and anti-inflammatory pathways in COVID-19 infection, but IL-10, an anti-inflammatory cytokine, has a role in suppressing the accumulation of T-cells specific to infection in the lower airways.
References: PMID: 36172119 / doi: 10.1101/2022.09.13.507852
Contact Info: Daniel Barber: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.09.13.507852v2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: NIAID; University of Plymoth, UK; The Vaccine Group Ltd, Plymouth, UK
Keywords: SARS-CoV-2, Molnupiravir and Nirmatrelvir, virus replication, pathology, primates
Summary of Study: Combination of molnupiravir and nirmatrelvir inhibits SARS-CoV-2 replication and shedding more effectively than individual treatments in the rhesus macaque model.
References: doi: 10.1101/2022.09.03.506479
Contact Info: Heinz Feldman: vog.hin.diain@hnnamdlef
URL: https://www.biorxiv.org/content/10.1101/2022.09.03.506479v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: NIAID; University of Plymoth, UK; The Vaccine Group Ltd, Plymouth, UK
Keywords: SARS-CoV-2, Molnupiravir and Nirmatrelvir, virus replication, pathology, primates
Summary of Study: Combination of molnupiravir and nirmatrelvir inhibits SARS-CoV-2 replication and shedding more effectively than individual treatments in the rhesus macaque model.
References: doi: 10.1101/2022.09.03.506479
Contact Info: Heinz Feldman: vog.hin.diain@hnnamdlef
URL: https://www.biorxiv.org/content/10.1101/2022.09.03.506479v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Emory, Tulane, Washington and Oregon National Primate Research Centers; Emory University School of Medicine; Weissman Institute of Science, Israel; Ulm University Medical Center, Germany, and others.
Keywords: SARS-CoV-2, IFN-I signaling, inflammasome activation, primates
Summary of Study: Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques
References: doi: 10.1101/2022.10.21.512606
Contact Info: Mirko Paiardini: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.10.21.512606v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Emory, Tulane, Washington and Oregon National Primate Research Centers; Emory University School of Medicine; Weissman Institute of Science, Israel; Ulm University Medical Center, Germany, and others.
Keywords: SARS-CoV-2, IFN-I signaling, inflammasome activation, primates
Summary of Study: Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques
References: doi: 10.1101/2022.10.21.512606
Contact Info: Mirko Paiardini: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.10.21.512606v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Sarafan ChEM-H, Stanford University, Stanford, CA; Department of Chemistry, Stanford University, Stanford, CA; Department of Biochemistry, School of Medicine, Stanford University, Stanford, CA; others
Keywords: SARS-CoV-2, ferritin-based, protein-nanoparticle vaccine, immune response, booster, primates
Summary of Study: A ferritin-based COVID-19 nanoparticle vaccine
References: doi: 10.1101/2022.12.25.521784
Contact Info: Peter S Kim: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.12.25.521784v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Sarafan ChEM-H, Stanford University, Stanford, CA; Department of Chemistry, Stanford University, Stanford, CA; Department of Biochemistry, School of Medicine, Stanford University, Stanford, CA; others
Keywords: SARS-CoV-2, ferritin-based, protein-nanoparticle vaccine, immune response, booster, primates
Summary of Study: A ferritin-based COVID-19 nanoparticle vaccine
References: doi: 10.1101/2022.12.25.521784
Contact Info: Peter S Kim: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.12.25.521784v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: NIAID, NHLBI, Emory NPRC, Bioqual, Inc.
Keywords: SARS-CoV-2, inflammation, clonal hematopoiesis, respiratory tract, primates
Summary of Study: Findings suggest potential pathophysiological differences with or without clonal hematopoiesis upon SARS-CoV-2 infection
References: doi: 10.1101/2023.01.01.522064
Contact Info: Tae-Hoon Shin: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.01.01.522064v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: NIAID, NHLBI, Emory NPRC, Bioqual, Inc.
Keywords: SARS-CoV-2, inflammation, clonal hematopoiesis, respiratory tract, primates
Summary of Study: Findings suggest potential pathophysiological differences with or without clonal hematopoiesis upon SARS-CoV-2 infection
References: doi: 10.1101/2023.01.01.522064
Contact Info: Tae-Hoon Shin: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.01.01.522064v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA; others
Keywords: SARS-CoV-2, receptor-binding domain, mosaic nanoparticles, immune response, rodents, primates
Summary of Study: Mosaic sarbecovirus vaccination elicits cross-reactive responses
References: PMID: 38370696 PMCID: PMC10871317 DOI: 10.1101/2024.02.08.576722
Contact Info: Pamela Bjorkman: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2024.02.08.576722v1
NHP Species: cynomolgus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA; others
Keywords: SARS-CoV-2, receptor-binding domain, mosaic nanoparticles, immune response, rodents, primates
Summary of Study: Mosaic sarbecovirus vaccination elicits cross-reactive responses
References: PMID: 38370696 PMCID: PMC10871317 DOI: 10.1101/2024.02.08.576722
Contact Info: Pamela Bjorkman: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2024.02.08.576722v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: pathogenesis
NPRC/Institute: Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, United States; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Keywords: SARS-CoV-2, neutralizing antibodies, immune response, anatomic compartments, primates
Summary of Study: Compartment-Specific Antibody Correlates of Protection to SARS-CoV-2 Omicron
References: PMID: 38464001 PMCID: PMC10925337 DOI: 10.1101/2024.03.01.582951
Contact Info: Dan H. Barouch: [email protected]; Ryan McNamara: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2024.03.01.582951v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: pathogenesis
NPRC/Institute: Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, United States; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Keywords: SARS-CoV-2, neutralizing antibodies, immune response, anatomic compartments, primates
Summary of Study: Compartment-Specific Antibody Correlates of Protection to SARS-CoV-2 Omicron
References: PMID: 38464001 PMCID: PMC10925337 DOI: 10.1101/2024.03.01.582951
Contact Info: Dan H. Barouch: [email protected]; Ryan McNamara: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2024.03.01.582951v1