Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: GigaGen, Inc.; Alira Health, Inc.; Grifols S.A.; Vitalant Research Institute; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, drugs, GMP, clinical manufacturing, therapy, mice, primates
Summary of Study: A novel class of drugs, recombinant hyperimmune globulins are a safe and protective possible treatment to COVID-19 that could be made through large-scale production.
References: PMID: 35890050 / doi: 10.3390/pathogens11070806
Contact Info: Adam Adler: aadler@gigagen.com
URL: https://www.mdpi.com/2076-0817/11/7/806
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: GigaGen, Inc.; Alira Health, Inc.; Grifols S.A.; Vitalant Research Institute; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, drugs, GMP, clinical manufacturing, therapy, mice, primates
Summary of Study: A novel class of drugs, recombinant hyperimmune globulins are a safe and protective possible treatment to COVID-19 that could be made through large-scale production.
References: PMID: 35890050 / doi: 10.3390/pathogens11070806
Contact Info: Adam Adler: aadler@gigagen.com
URL: https://www.mdpi.com/2076-0817/11/7/806
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Research Institute for Biological Safety Problems, Kazakhstan
Keywords: SARS-CoV-2, inactivated vaccine, safety, immune response, several animal species, primates
Summary of Study: The first COVID-19 inactivated vaccine developed in Kazakhstan did not result in any adverse effect or change in condition of the animals' health, has high immunogenic potential, and is safe to move to clinical research.
References: PMID: 35960911 / doi: 10.1080/21645515.2022.2087412
Contact Info: Zhandos Abay: abai.zhandos15@gmail.com
URL: https://www.tandfonline.com/doi/full/10.1080/21645515.2022.2087412
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Research Institute for Biological Safety Problems, Kazakhstan
Keywords: SARS-CoV-2, inactivated vaccine, safety, immune response, several animal species, primates
Summary of Study: The first COVID-19 inactivated vaccine developed in Kazakhstan did not result in any adverse effect or change in condition of the animals' health, has high immunogenic potential, and is safe to move to clinical research.
References: PMID: 35960911 / doi: 10.1080/21645515.2022.2087412
Contact Info: Zhandos Abay: abai.zhandos15@gmail.com
URL: https://www.tandfonline.com/doi/full/10.1080/21645515.2022.2087412
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA; numerous others
Keywords: SARS-CoV-2, vaccine, Ad26.COV2.S, spike ferritin nanoparticles, immune response, primates
Summary of Study: Protection against SARS-CoV-2 Omicron BA.1 variant challenge
References: doi: 10.1126/sciadv.ade4433
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.science.org/doi/10.1126/sciadv.ade4433
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA; numerous others
Keywords: SARS-CoV-2, vaccine, Ad26.COV2.S, spike ferritin nanoparticles, immune response, primates
Summary of Study: Protection against SARS-CoV-2 Omicron BA.1 variant challenge
References: doi: 10.1126/sciadv.ade4433
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.science.org/doi/10.1126/sciadv.ade4433
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: City of Hope National Medical Center
Keywords: SARS-CoV-2, synthetic multiantigen modified vaccine, COH04S1, immune response, hamsters, primates
Summary of Study: Vaccine candidate C0H04S1 stimulates protective immunity against SARS-CoV-2 in Syrian hamsters by intramuscular and intranasal vaccination and in non-human primates through two-dose and single-dose regimens.
References: PMID: 35064109 / doi: 10.1038/s41541-022-00436-6
Contact Info: Felix Wussow: fwussow@coh.org
URL: https://www.nature.com/articles/s41541-022-00436-6
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: City of Hope National Medical Center
Keywords: SARS-CoV-2, synthetic multiantigen modified vaccine, COH04S1, immune response, hamsters, primates
Summary of Study: Vaccine candidate C0H04S1 stimulates protective immunity against SARS-CoV-2 in Syrian hamsters by intramuscular and intranasal vaccination and in non-human primates through two-dose and single-dose regimens.
References: PMID: 35064109 / doi: 10.1038/s41541-022-00436-6
Contact Info: Felix Wussow: fwussow@coh.org
URL: https://www.nature.com/articles/s41541-022-00436-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences & Peking Union Medical College; National Institute for Viral Disease Control and Prevention
Keywords: SARS-CoV-2, inactivated vaccine, pathology, virus variants, primates
Summary of Study: Three doses of a prototypic SARS-CoV-2 inactivated vaccine reduced viral loads in nasal, throat and anal swabs and pulmonary tissues and improved the pathological changes lungs of animals infected by variants of Alpha, Beta and Delta.
References: PMID: 35217639 / doi: 10.1038/s41392-022-00920-4
Contact Info: Zhongping Xie: szp@imbcams.com.cn; Wenjie Tan: tanwj@ivdc.chinacdc.cn
URL: https://www.nature.com/articles/s41392-022-00920-4
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences & Peking Union Medical College; National Institute for Viral Disease Control and Prevention
Keywords: SARS-CoV-2, inactivated vaccine, pathology, virus variants, primates
Summary of Study: Three doses of a prototypic SARS-CoV-2 inactivated vaccine reduced viral loads in nasal, throat and anal swabs and pulmonary tissues and improved the pathological changes lungs of animals infected by variants of Alpha, Beta and Delta.
References: PMID: 35217639 / doi: 10.1038/s41392-022-00920-4
Contact Info: Zhongping Xie: szp@imbcams.com.cn; Wenjie Tan: tanwj@ivdc.chinacdc.cn
URL: https://www.nature.com/articles/s41392-022-00920-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Michigan Technological University; Tulane University
Keywords: SARS-CoV-2, renin-angiotensin system, HIV co-infection, gene expression, primates
Summary of Study: Findings suggest a possible impact of SIV/HIV infection on expression of ACE2 and RAS-associated proteins resulting in the loss of gut homeostasis.
References: PMID: 35281029 / doi: 10.3389/fimmu.2022.835686
Contact Info: Bapi Pahar: bpahar@trudeauinstitute.org
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.835686/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Michigan Technological University; Tulane University
Keywords: SARS-CoV-2, renin-angiotensin system, HIV co-infection, gene expression, primates
Summary of Study: Findings suggest a possible impact of SIV/HIV infection on expression of ACE2 and RAS-associated proteins resulting in the loss of gut homeostasis.
References: PMID: 35281029 / doi: 10.3389/fimmu.2022.835686
Contact Info: Bapi Pahar: bpahar@trudeauinstitute.org
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.835686/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Massachusetts Institute of Technology; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University; Scripps Research Institute; University of Louisiana at Lafayette; Beth Israel Deaconess Medical Center, Harvard Medical School; Howard Hughes Medical Institute
Keywords: SARS-CoV-2, lipid-conjugated immunogen, intranasal vaccination, mice, primates
Summary of Study: To combat the problem of poor vaccine uptake across mucus and epithelial linings, intranasal immunization with amphilic albumin binding components was created with the ability to be delivered across the mucosal epithelium and generate an antigen-specific response.
References: PMID: 35857825 / doi: 10.1126/scitranslmed.abn1413
Contact Info: Darrell Irvine: djirvine@mit.edu
URL: https://www.science.org/doi/10.1126/scitranslmed.abn1413?url_ver=Z39.88-2003&rf…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Massachusetts Institute of Technology; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University; Scripps Research Institute; University of Louisiana at Lafayette; Beth Israel Deaconess Medical Center, Harvard Medical School; Howard Hughes Medical Institute
Keywords: SARS-CoV-2, lipid-conjugated immunogen, intranasal vaccination, mice, primates
Summary of Study: To combat the problem of poor vaccine uptake across mucus and epithelial linings, intranasal immunization with amphilic albumin binding components was created with the ability to be delivered across the mucosal epithelium and generate an antigen-specific response.
References: PMID: 35857825 / doi: 10.1126/scitranslmed.abn1413
Contact Info: Darrell Irvine: djirvine@mit.edu
URL: https://www.science.org/doi/10.1126/scitranslmed.abn1413?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences & Peking Union Medical College; Kunming No.1 High School; Kunming National High-level Biosafety Primate Research Center
Keywords: SARS-CoV-2, vaccines, repertoire diversities of B cells and T cells, whole-virus inactivated and S1 protein subunit vaccine, primates
Summary of Study: Comparison of B-cell and T-cell responses between a whole-virus inactivated vaccine and an S1 protein subunit vaccine.
References: PMID: 36070519 / doi: 10.1080/21645515.2022.2118477
Contact Info: Huiwen Zheng: sunming@imbcams.com.cn
URL: https://www.tandfonline.com/doi/full/10.1080/21645515.2022.2118477
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences & Peking Union Medical College; Kunming No.1 High School; Kunming National High-level Biosafety Primate Research Center
Keywords: SARS-CoV-2, vaccines, repertoire diversities of B cells and T cells, whole-virus inactivated and S1 protein subunit vaccine, primates
Summary of Study: Comparison of B-cell and T-cell responses between a whole-virus inactivated vaccine and an S1 protein subunit vaccine.
References: PMID: 36070519 / doi: 10.1080/21645515.2022.2118477
Contact Info: Huiwen Zheng: sunming@imbcams.com.cn
URL: https://www.tandfonline.com/doi/full/10.1080/21645515.2022.2118477
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Milan, Milan, Italy
Keywords: SARS-CoV-2, review, natural and experimental infection, several animal species, primates
Summary of Study: Review updating information on natural and experimental SARS-CoV-2 infections in animals.
References: doi: 10.1007/s00705-022-05609-1
Contact Info: Lauretta Turin: ti.iminu@nirut.atterual
URL: https://link.springer.com/article/10.1007/s00705-022-05609-1
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Milan, Milan, Italy
Keywords: SARS-CoV-2, review, natural and experimental infection, several animal species, primates
Summary of Study: Review updating information on natural and experimental SARS-CoV-2 infections in animals.
References: doi: 10.1007/s00705-022-05609-1
Contact Info: Lauretta Turin: ti.iminu@nirut.atterual
URL: https://link.springer.com/article/10.1007/s00705-022-05609-1
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane University, Memorial Sloan Kettering Cancer Ctr, Weill Cornell Medical College, Instuto de Química Pontificia Universidad Católica de Valparaíso
Keywords: SARS-CoV-2, urokinase plasminogen activator receptor, renal dysfunction, pathology, primates
Summary of Study: Elevated soluble urokinase plasminogen activator receptor
References: doi: 10.1111/jmp.12626
Contact Info: Minolfa Prieto: mprieto@tulane.edu
URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/jmp.12626
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane University, Memorial Sloan Kettering Cancer Ctr, Weill Cornell Medical College, Instuto de Química Pontificia Universidad Católica de Valparaíso
Keywords: SARS-CoV-2, urokinase plasminogen activator receptor, renal dysfunction, pathology, primates
Summary of Study: Elevated soluble urokinase plasminogen activator receptor
References: doi: 10.1111/jmp.12626
Contact Info: Minolfa Prieto: mprieto@tulane.edu
URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/jmp.12626
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Emergent BioSolutions; Yoh Services LLC; Sanofi Pasteur; Translate Bio; UT Health Science Center at Houston
Keywords: SARS-CoV-2, virus variants, vaccine, boost, neutralizing effects, primates
Summary of Study: This study showed that a third vaccination administered as a booster, regardless of composition, to the currently approved two dose regimens could effectively promote broadly neutralizing antibodies against all variants of concern.
References: PMID: 35101265 / doi: 10.1016/j.vaccine.2022.01.021
Contact Info: Natalie Anosova: natalie.anosova@sanofi.com
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22000457?via%3Dihub=
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Emergent BioSolutions; Yoh Services LLC; Sanofi Pasteur; Translate Bio; UT Health Science Center at Houston
Keywords: SARS-CoV-2, virus variants, vaccine, boost, neutralizing effects, primates
Summary of Study: This study showed that a third vaccination administered as a booster, regardless of composition, to the currently approved two dose regimens could effectively promote broadly neutralizing antibodies against all variants of concern.
References: PMID: 35101265 / doi: 10.1016/j.vaccine.2022.01.021
Contact Info: Natalie Anosova: natalie.anosova@sanofi.com
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22000457?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: China Pharmaceutical University; Yunnan Walvax Biotech
Keywords: SARS-CoV-2, chimpanzee adenovirus-based vaccine, immunogenicity, toxicology, rats, primates
Summary of Study: AdC68-19S, a recombinant chimpanzee adenovirus serotype 68 vector-based vaccine encoding the full-length spike protein of SARS-CoV-2, induced an effective immune response with a good safety profile in rhesus macaques.
References: PMID: 35226134 / doi: 10.1007/s00204-021-03221-x
Contact Info: Zhen Huang: hz@walvax.com
URL: https://link.springer.com/article/10.1007/s00204-021-03221-x
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: China Pharmaceutical University; Yunnan Walvax Biotech
Keywords: SARS-CoV-2, chimpanzee adenovirus-based vaccine, immunogenicity, toxicology, rats, primates
Summary of Study: AdC68-19S, a recombinant chimpanzee adenovirus serotype 68 vector-based vaccine encoding the full-length spike protein of SARS-CoV-2, induced an effective immune response with a good safety profile in rhesus macaques.
References: PMID: 35226134 / doi: 10.1007/s00204-021-03221-x
Contact Info: Zhen Huang: hz@walvax.com
URL: https://link.springer.com/article/10.1007/s00204-021-03221-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beijing Institute of Microbiology and Epidemiology; Sinocelltech, Ltd.; Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, polysaccharide–protein-conjugated nanoparticle vaccine, virus variants, mice, rats, primates
Summary of Study: A novel nanoparticle vaccine was designed and prepared by chemically conjugating recombinant SARD-CoV-2 RBD and PPS14. Studies have demonstrated that SCTV01B vaccination induced potent and broad neutralizing antibodies and cellular immune responses against SARS-CoV-2 in mice, rats, and nonhuman primates, as well as high OPA against S. pneumoniae serotype 14.
References: PMID: 35332581 / doi: 10.1002/adma.202200443
Contact Info: Liangzhi Xie: liangzhi@yahoo.com
URL: https://onlinelibrary.wiley.com/doi/10.1002/adma.202200443
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beijing Institute of Microbiology and Epidemiology; Sinocelltech, Ltd.; Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, polysaccharide–protein-conjugated nanoparticle vaccine, virus variants, mice, rats, primates
Summary of Study: A novel nanoparticle vaccine was designed and prepared by chemically conjugating recombinant SARD-CoV-2 RBD and PPS14. Studies have demonstrated that SCTV01B vaccination induced potent and broad neutralizing antibodies and cellular immune responses against SARS-CoV-2 in mice, rats, and nonhuman primates, as well as high OPA against S. pneumoniae serotype 14.
References: PMID: 35332581 / doi: 10.1002/adma.202200443
Contact Info: Liangzhi Xie: liangzhi@yahoo.com
URL: https://onlinelibrary.wiley.com/doi/10.1002/adma.202200443
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Peking Union Medical College; National Center of Technology Innovation for Animal Model; Chinese Academy of Sciences; Capital Medical University
Keywords: SARS-CoV-2, inactivated vaccine, booster, immune response, virus variants, primates
Summary of Study: Animals administered with an indicated booster dose and subsequently challenged with Delta or Omicron variants showed markedly reduced viral loads and improved histopathological profiles compared to control animals, indicating that sequential immunization could protect primates against Omicron.
References: PMID: 35436986 / doi: 10.1038/s41392-022-00979-z
Contact Info: Chuan Qin: qinchuan@pumc.edu.cn;
URL: https://www.nature.com/articles/s41392-022-00979-z
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Peking Union Medical College; National Center of Technology Innovation for Animal Model; Chinese Academy of Sciences; Capital Medical University
Keywords: SARS-CoV-2, inactivated vaccine, booster, immune response, virus variants, primates
Summary of Study: Animals administered with an indicated booster dose and subsequently challenged with Delta or Omicron variants showed markedly reduced viral loads and improved histopathological profiles compared to control animals, indicating that sequential immunization could protect primates against Omicron.
References: PMID: 35436986 / doi: 10.1038/s41392-022-00979-z
Contact Info: Chuan Qin: qinchuan@pumc.edu.cn;
URL: https://www.nature.com/articles/s41392-022-00979-z
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: The Broad Institute of Harvard and MIT; Harvard University; Universite Paris-Saclay, Inserm, CEA; Genethon INTEGRARE UMR; Rega Institute; University of Siena; University of Pennsylvania
Keywords: SARS-CoV-2, AAV-based vaccine, virus variants, immune response, mice, primates
Summary of Study: AAV-based vaccines for COVID-19 can be effective from a single, low dose and lead to durable humoral and strong T cell immunogenicity.
References: PMID: 35546782 / doi: 10.1016/j.ymthe.2022.05.007
Contact Info: Luk Vandenberghe: luk_vandenberghe@meei.harvard.edu
URL: https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-…
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: The Broad Institute of Harvard and MIT; Harvard University; Universite Paris-Saclay, Inserm, CEA; Genethon INTEGRARE UMR; Rega Institute; University of Siena; University of Pennsylvania
Keywords: SARS-CoV-2, AAV-based vaccine, virus variants, immune response, mice, primates
Summary of Study: AAV-based vaccines for COVID-19 can be effective from a single, low dose and lead to durable humoral and strong T cell immunogenicity.
References: PMID: 35546782 / doi: 10.1016/j.ymthe.2022.05.007
Contact Info: Luk Vandenberghe: luk_vandenberghe@meei.harvard.edu
URL: https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses; Jilin University First Hospital; Beijing Institute of Biotechnology; College of Basic Medical Sciences; Zhongshan Hospital Fudan University; Beijing Institute of Microbiology and Epidemiology; Shaanxi Normal University
Keywords: SARS-CoV-2, proteomics, metabolomics, pathology, immune response, primates
Summary of Study: An established COVID-19 model demonstrates that the innate immune response, neutrophil and platelet activation were dysregulated in infected NHPs, and these were greatly weakened in the most infected NHPs, which models moderately infected humans.
References: PMID: 35903092 / doi: 10.3389/fimmu.2022.954121
Contact Info: Yuwei Gao: yuwei0901@outlook.com; Yan Liu: liu820512@163.com; Xiaochang Xue: xuexch@snnu.edu.cn; Hui Wang: geno0109@vip.sina.com
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.954121/full
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses; Jilin University First Hospital; Beijing Institute of Biotechnology; College of Basic Medical Sciences; Zhongshan Hospital Fudan University; Beijing Institute of Microbiology and Epidemiology; Shaanxi Normal University
Keywords: SARS-CoV-2, proteomics, metabolomics, pathology, immune response, primates
Summary of Study: An established COVID-19 model demonstrates that the innate immune response, neutrophil and platelet activation were dysregulated in infected NHPs, and these were greatly weakened in the most infected NHPs, which models moderately infected humans.
References: PMID: 35903092 / doi: 10.3389/fimmu.2022.954121
Contact Info: Yuwei Gao: yuwei0901@outlook.com; Yan Liu: liu820512@163.com; Xiaochang Xue: xuexch@snnu.edu.cn; Hui Wang: geno0109@vip.sina.com
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.954121/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Betuvax LLC; Lomonosov Moscow State University; Clinical Excellence Group LLC; I.I. Mechnikov North-Western State Medical University; PJSC Human Stem Cells Institute; Center of Genetics and Reproductive Medicine; Sechenov First Moscow State Medical University; Biotechnology Developments LLC; Ministry of Health of the Russian Federation
Keywords: SARS-CoV-2, subunit vaccine, “Betuvax-CoV-2”, preclinical studies, several animal species, primates
Summary of Study: A vaccine developed as a subunit that contains a recombinant receptor-binding domain fusion protein and virus-like nanoparticles demonstrates effective protection through COVID-19 neutralizing antibody production and conferring infection and lung damage protection.
References: PMID: 36016181 / doi: 10.3390/vaccines10081290
Contact Info: Anna Vakrusheva: vakhrusheva@betuvax.ru
URL: https://www.mdpi.com/2076-393X/10/8/1290
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Betuvax LLC; Lomonosov Moscow State University; Clinical Excellence Group LLC; I.I. Mechnikov North-Western State Medical University; PJSC Human Stem Cells Institute; Center of Genetics and Reproductive Medicine; Sechenov First Moscow State Medical University; Biotechnology Developments LLC; Ministry of Health of the Russian Federation
Keywords: SARS-CoV-2, subunit vaccine, “Betuvax-CoV-2”, preclinical studies, several animal species, primates
Summary of Study: A vaccine developed as a subunit that contains a recombinant receptor-binding domain fusion protein and virus-like nanoparticles demonstrates effective protection through COVID-19 neutralizing antibody production and conferring infection and lung damage protection.
References: PMID: 36016181 / doi: 10.3390/vaccines10081290
Contact Info: Anna Vakrusheva: vakhrusheva@betuvax.ru
URL: https://www.mdpi.com/2076-393X/10/8/1290
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, numerous others
Keywords: SARS-CoV-2, vaccine, BNT162b2, mRNA-1273, infants, immune response, primates
Summary of Study: Protection in immunized infant macaques
References: doi: 10.1126/scitranslmed.add6383
Contact Info: Kristina de Paris: abelk@med.unc.edu
URL: https://www.science.org/doi/10.1126/scitranslmed.add6383
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, numerous others
Keywords: SARS-CoV-2, vaccine, BNT162b2, mRNA-1273, infants, immune response, primates
Summary of Study: Protection in immunized infant macaques
References: doi: 10.1126/scitranslmed.add6383
Contact Info: Kristina de Paris: abelk@med.unc.edu
URL: https://www.science.org/doi/10.1126/scitranslmed.add6383
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Washington University; National Cancer Institute/NIH; Bioqual; Oak Ridge Institute of Science & Education; Columbia University Vagelos College of Physicians and Surgeons; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, spike protein ferritin nanoparticle (SpFN) vaccine, immune response, primates
Summary of Study: NHPs vaccinated with two doses of SpFN plus adjuvant separated by 28 days developed potent SARS-CoV-2-specific B and T cell responses, which conferred protection against SARS-CoV-2 challenge.
References: PMID: 34914540 / doi: 10.1126/scitranslmed.abi5735
Contact Info: Kayvon Modjarrad: kayvon.modjarrad.civ@mail.mil
URL: https://www.science.org/doi/10.1126/scitranslmed.abi5735?url_ver=Z39.88-2003&rf…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Washington University; National Cancer Institute/NIH; Bioqual; Oak Ridge Institute of Science & Education; Columbia University Vagelos College of Physicians and Surgeons; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, spike protein ferritin nanoparticle (SpFN) vaccine, immune response, primates
Summary of Study: NHPs vaccinated with two doses of SpFN plus adjuvant separated by 28 days developed potent SARS-CoV-2-specific B and T cell responses, which conferred protection against SARS-CoV-2 challenge.
References: PMID: 34914540 / doi: 10.1126/scitranslmed.abi5735
Contact Info: Kayvon Modjarrad: kayvon.modjarrad.civ@mail.mil
URL: https://www.science.org/doi/10.1126/scitranslmed.abi5735?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: prevention
NPRC/Institute: University of Washington; Washington National Primate Research Center; Institute of Biomedical Sciences, Taipei; Fred Hutchinson Cancer Research Center
Keywords: SARS-CoV-2, helper-dependent adenovirus (HDAd5/35++), HSC gene therapy, safety, virus protection, mice, primates
Summary of Study: Pilot studies of a simple and portable in vivo hematopoietic HSC transduction approach that involves HSC mobilization from the bone marrow into the peripheral blood stream and the intravenous injection of an integrating, helper-dependent adenovirus vector system demonstrated safety and efficacy in mice and a rhesus macaque.
References: PMID: 35057635 / doi: 10.1089/hum.2021.295
Contact Info: Andre Lieber: lieber00@uw.edu; Steve Roffler: sroff@ibms.sinica.edu.tw; Hans-Peter Kiem: hkiem@fredhutch.org; Deborah Fuller: fullerdh@uw.edu
URL: https://www.liebertpub.com/doi/10.1089/hum.2021.295?url_ver=Z39.88-2003&rfr_id=…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: prevention
NPRC/Institute: University of Washington; Washington National Primate Research Center; Institute of Biomedical Sciences, Taipei; Fred Hutchinson Cancer Research Center
Keywords: SARS-CoV-2, helper-dependent adenovirus (HDAd5/35++), HSC gene therapy, safety, virus protection, mice, primates
Summary of Study: Pilot studies of a simple and portable in vivo hematopoietic HSC transduction approach that involves HSC mobilization from the bone marrow into the peripheral blood stream and the intravenous injection of an integrating, helper-dependent adenovirus vector system demonstrated safety and efficacy in mice and a rhesus macaque.
References: PMID: 35057635 / doi: 10.1089/hum.2021.295
Contact Info: Andre Lieber: lieber00@uw.edu; Steve Roffler: sroff@ibms.sinica.edu.tw; Hans-Peter Kiem: hkiem@fredhutch.org; Deborah Fuller: fullerdh@uw.edu
URL: https://www.liebertpub.com/doi/10.1089/hum.2021.295?url_ver=Z39.88-2003&rfr_id=…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Henry M. Jackson Foundation for the Advancement of Military Medicine; Washington University; NCI/NIH; Bioqual; Oak Ridge Institute of Science and Education; Columbia University Vagelos College of Physicians and Surgeons; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, nanoparticle vaccine, cellular and humoral immune responses, primates
Summary of Study: Nonhuman primates vaccinated with two doses of SpFN (a SARS-CoV-2 spike protein ferritin nanoparticle vaccine) were protected against SARS-CoV-2 challenge. SErum isolated from vaccinated animals neutralized several variants of concern, including the delta variant.
References: PMID: 39414540 / doi: 10.1126/scitranslmed.abi5735
Contact Info: M. Gordon Joyce: gjoyce@eidresearch.org; Kayvon Modjarrad: kayvon.modjarrad.civ@mail.mil
URL: https://www.science.org/doi/10.1126/scitranslmed.abi5735
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Henry M. Jackson Foundation for the Advancement of Military Medicine; Washington University; NCI/NIH; Bioqual; Oak Ridge Institute of Science and Education; Columbia University Vagelos College of Physicians and Surgeons; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, nanoparticle vaccine, cellular and humoral immune responses, primates
Summary of Study: Nonhuman primates vaccinated with two doses of SpFN (a SARS-CoV-2 spike protein ferritin nanoparticle vaccine) were protected against SARS-CoV-2 challenge. SErum isolated from vaccinated animals neutralized several variants of concern, including the delta variant.
References: PMID: 39414540 / doi: 10.1126/scitranslmed.abi5735
Contact Info: M. Gordon Joyce: gjoyce@eidresearch.org; Kayvon Modjarrad: kayvon.modjarrad.civ@mail.mil
URL: https://www.science.org/doi/10.1126/scitranslmed.abi5735
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: MIT; Scripps Research Institute; La Jolla Institute for Immunology; Ragon Institute of Massachusetts General Hospital, MIT, and Harvard University; University of California, San Diego; Yerkes National Primate Research Center; Emory University School of Medicine; MIT
Keywords: SARS-CoV-2, saponin/TLR agonist, vaccine adjuvant, immune response, primates
Summary of Study: Compared with a panel of tested adjuvants including other saponin-based formulations, saponin/MPLA nanoparticles (SMNP) induced superior antibody and germinal center responses after immunization with a poorly immunogenic HIV antigen in both mice and rhesus macaques, suggesting that SMNP may be a promising adjuvant in the setting of HIV, SARS-CoV-2, and other pathogens.
References: PMID: 34860581 / doi: 10.1126/sciimmunol.abf1152
Contact Info: Darrell J. Irvine: djirvine@mit.edu; Shane Crotty: shane@lji.org
URL: https://www.science.org/doi/10.1126/sciimmunol.abf1152?url_ver=Z39.88-2003&rfr_…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: MIT; Scripps Research Institute; La Jolla Institute for Immunology; Ragon Institute of Massachusetts General Hospital, MIT, and Harvard University; University of California, San Diego; Yerkes National Primate Research Center; Emory University School of Medicine; MIT
Keywords: SARS-CoV-2, saponin/TLR agonist, vaccine adjuvant, immune response, primates
Summary of Study: Compared with a panel of tested adjuvants including other saponin-based formulations, saponin/MPLA nanoparticles (SMNP) induced superior antibody and germinal center responses after immunization with a poorly immunogenic HIV antigen in both mice and rhesus macaques, suggesting that SMNP may be a promising adjuvant in the setting of HIV, SARS-CoV-2, and other pathogens.
References: PMID: 34860581 / doi: 10.1126/sciimmunol.abf1152
Contact Info: Darrell J. Irvine: djirvine@mit.edu; Shane Crotty: shane@lji.org
URL: https://www.science.org/doi/10.1126/sciimmunol.abf1152?url_ver=Z39.88-2003&rfr_…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Biomedical Primate Research Centre; Consejo Superior de Investigaciones Cientificas (CSIC); Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas (CIBERINFEC); Erasmus Medical Center; Instituto de Investigacion Hospital Universitario 12 de Octubre (imas12); Universidad Complutense School of Medicine, Biofabri
Keywords: SARS-CoV-2, vaccine, modified vaccinia virus Ankara vector, immune response, primates
Summary of Study: The MVA-S vaccine is safe and well tolerated in rhesus macaques, being highly immunogenic with the induction of potent levels of binding and neutralizing antibodies against several SARS-CoV-2 VOC, as well as Th1-skewed cell responses.
References: PMID: 35371043 / doi: 10.3389/fimmu.2022.845887
Contact Info: Petra Mooij: mooij@bprc.nl; Juan Garcia-Arriaza: jfgarcia@cnb.csic.ed; Gerrit Koopman: koopman@bprc.nl; Mariano Esteban: mesteban@cnb.csic.es
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.845887/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Biomedical Primate Research Centre; Consejo Superior de Investigaciones Cientificas (CSIC); Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas (CIBERINFEC); Erasmus Medical Center; Instituto de Investigacion Hospital Universitario 12 de Octubre (imas12); Universidad Complutense School of Medicine, Biofabri
Keywords: SARS-CoV-2, vaccine, modified vaccinia virus Ankara vector, immune response, primates
Summary of Study: The MVA-S vaccine is safe and well tolerated in rhesus macaques, being highly immunogenic with the induction of potent levels of binding and neutralizing antibodies against several SARS-CoV-2 VOC, as well as Th1-skewed cell responses.
References: PMID: 35371043 / doi: 10.3389/fimmu.2022.845887
Contact Info: Petra Mooij: mooij@bprc.nl; Juan Garcia-Arriaza: jfgarcia@cnb.csic.ed; Gerrit Koopman: koopman@bprc.nl; Mariano Esteban: mesteban@cnb.csic.es
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.845887/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre (BPRC), Rijswijk, Netherlands; Department of Radiology and Nuclear Medicine, Tracer Center Amsterdam (TCA), Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands
Keywords: SARS-CoV-2, PET-CT imaging, lungs, inflammation, primates
Summary of Study: Vaccine candiate involving a valuable radiotracer to visualize SARS-CoV-2-associated pulmonary inflammation
References: PMID: 35660200 PMCID: PMC9148436 DOI: 10.1016/j.nucmedbio.2022.05.002
Contact Info: Marieke A Stammes: stammes@bprc.nl
URL: https://www.sciencedirect.com/science/article/pii/S0969805122020509?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre (BPRC), Rijswijk, Netherlands; Department of Radiology and Nuclear Medicine, Tracer Center Amsterdam (TCA), Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands
Keywords: SARS-CoV-2, PET-CT imaging, lungs, inflammation, primates
Summary of Study: Vaccine candiate involving a valuable radiotracer to visualize SARS-CoV-2-associated pulmonary inflammation
References: PMID: 35660200 PMCID: PMC9148436 DOI: 10.1016/j.nucmedbio.2022.05.002
Contact Info: Marieke A Stammes: stammes@bprc.nl
URL: https://www.sciencedirect.com/science/article/pii/S0969805122020509?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2022
Study Type/Review:
NPRC/Institute: Defence Science and Technology Laboratory; United Kingdom Health and Security Agency
Keywords: SARS-CoV-2, aerosolized virus, pathology, immune response, primates
Summary of Study: Following COVID-19 exposure, marmosets did not develop clinical signs other than a disruption to the diurnal temperature rhythm. This may be due to an innate immunological response, which included an increase in neutrophils and monocytes and a reduction in T-cells.
References: PMID: 35891560 / doi: 10.3390/v14071580
Contact Info: Rachel Ireland: reireland@dstl.gov.uk
URL: https://www.mdpi.com/1999-4915/14/7/1580
NHP Species: marmosets
Year Published: 2022
Study Type/Review:
NPRC/Institute: Defence Science and Technology Laboratory; United Kingdom Health and Security Agency
Keywords: SARS-CoV-2, aerosolized virus, pathology, immune response, primates
Summary of Study: Following COVID-19 exposure, marmosets did not develop clinical signs other than a disruption to the diurnal temperature rhythm. This may be due to an innate immunological response, which included an increase in neutrophils and monocytes and a reduction in T-cells.
References: PMID: 35891560 / doi: 10.3390/v14071580
Contact Info: Rachel Ireland: reireland@dstl.gov.uk
URL: https://www.mdpi.com/1999-4915/14/7/1580
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: China Biotechnology Co.LTD; Beijing Chaoyang Hospital, Capital Medical University; Laboratory Animal Center, Academy of Military Medical Sciences
Keywords: SARS-CoV-2, angiotensin-converting enzyme 2, gene sequences, primates
Summary of Study: Angiotensin-converting enzyme (ACE2) binds to the SARS-CoV2 virus as a receptor, and variation of the ACE2 sequence and binding affinity may account for differences in susceptibility and responses to infection
References: PMID: 36105891 / doi: 10.1016/j.bsheal.2022.09.001
Contact Info: Xiaojun Zhou, Jingjing Zhao, Yefeng Qiu, Rui Jia
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461283/
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: China Biotechnology Co.LTD; Beijing Chaoyang Hospital, Capital Medical University; Laboratory Animal Center, Academy of Military Medical Sciences
Keywords: SARS-CoV-2, angiotensin-converting enzyme 2, gene sequences, primates
Summary of Study: Angiotensin-converting enzyme (ACE2) binds to the SARS-CoV2 virus as a receptor, and variation of the ACE2 sequence and binding affinity may account for differences in susceptibility and responses to infection
References: PMID: 36105891 / doi: 10.1016/j.bsheal.2022.09.001
Contact Info: Xiaojun Zhou, Jingjing Zhao, Yefeng Qiu, Rui Jia
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461283/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Respiratory Disease, China; Guanzhou Laboratory, China; University of Science and Technology Hong Kong, numerous others
Keywords: SARS-CoV-2, spike protein vaccine, immune response, virus variants, mice, primates
Summary of Study: RBMRNA-176 is a vaccine candidate for prevention of COVID-19
References: doi: 10.3390/vaccines10101698
Contact Info: Wei Yang: yangwei@lewwin.com.cn
URL: https://www.mdpi.com/2076-393X/10/10/1698
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Respiratory Disease, China; Guanzhou Laboratory, China; University of Science and Technology Hong Kong, numerous others
Keywords: SARS-CoV-2, spike protein vaccine, immune response, virus variants, mice, primates
Summary of Study: RBMRNA-176 is a vaccine candidate for prevention of COVID-19
References: doi: 10.3390/vaccines10101698
Contact Info: Wei Yang: yangwei@lewwin.com.cn
URL: https://www.mdpi.com/2076-393X/10/10/1698
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID Laboratory of Virology and NIAID Rocky Mountain Veterinary Branch, Hamilton, MT
Keywords: SARS-CoV-2, pathology, virus variants, primates
Summary of Study: Omicron BA.1 and BA.2 are attenuated in rhesus macaques as compared to Delta
References: doi: 10.1126/sciadv.ade1860
Contact Info: Kyle Rosenke: kyle.rosenke@nih.gov
URL: https://www.science.org/doi/10.1126/sciadv.ade1860
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID Laboratory of Virology and NIAID Rocky Mountain Veterinary Branch, Hamilton, MT
Keywords: SARS-CoV-2, pathology, virus variants, primates
Summary of Study: Omicron BA.1 and BA.2 are attenuated in rhesus macaques as compared to Delta
References: doi: 10.1126/sciadv.ade1860
Contact Info: Kyle Rosenke: kyle.rosenke@nih.gov
URL: https://www.science.org/doi/10.1126/sciadv.ade1860
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Fudan University; The University of Hong Kong; Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park; Graduate School of Peking Union Medical College; Natinal Institute for Food and Drug Control, Beijing, China; Fulgent Pharma LLC
Keywords: SARS-CoV-2, pan-sarbecovirus vaccine, immune response, virus variants, primates
Summary of Study: A pan-sarbecovirus vaccine consisting of human IgG Fc fragment-conjugated RBC of the original SARS-CoV-2 WA1 strain as the immunogen and a novel small-molecule non-nucleotide STING agonist as the adjuvant could be used to prevent infection by the current SARS-CoV-2 variants, including Omicron, and future emerging sarbecoviruses.
References: PMID: 35210607 / doi: 10. 1038/s41422-022-00631-z
Contact Info: Youchun Wang: wangyc@nifdc.org.cn
URL: https://www.nature.com/articles/s41422-022-00631-z
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Fudan University; The University of Hong Kong; Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park; Graduate School of Peking Union Medical College; Natinal Institute for Food and Drug Control, Beijing, China; Fulgent Pharma LLC
Keywords: SARS-CoV-2, pan-sarbecovirus vaccine, immune response, virus variants, primates
Summary of Study: A pan-sarbecovirus vaccine consisting of human IgG Fc fragment-conjugated RBC of the original SARS-CoV-2 WA1 strain as the immunogen and a novel small-molecule non-nucleotide STING agonist as the adjuvant could be used to prevent infection by the current SARS-CoV-2 variants, including Omicron, and future emerging sarbecoviruses.
References: PMID: 35210607 / doi: 10. 1038/s41422-022-00631-z
Contact Info: Youchun Wang: wangyc@nifdc.org.cn
URL: https://www.nature.com/articles/s41422-022-00631-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tsinghua University; Chongqing Medical University; Boston University School of Medicine; Chinese Academy of Sciences; Shenzhen Bay Laboratory; Peking University Shenshen Graduate School; Fudan University
Keywords: SARS-CoV-2, pathogenesis, neutralization antibodies, primates
Summary of Study: Kappa, Delta, or B.1.618 spike uses human angiotensin-converting enzyme 2 (ACE2) with no or slightly increased efficiency, while it gains a significantly increased binding affinity with mouse, marmoset, and koala ACE2 orthologs, which exhibit limited binding with wild-type (WT) spike. Collectively, this study revealed that enhanced human and mouse ASE receptor engagement, increased spike cleavage, and reduced sensitivity to neutralization antibodies of Kapa, Delta and B.1.618 may contribute to the rapid spread of these variants.
References: PMID: 35266815 / doi: 10.1128/mbio.00099-22
Contact Info: Qiang Ding: qding@tsinghua.edu.cn
URL: https://journals.asm.org/doi/full/10.1128/mbio.00099-22?rfr_dat=cr_pub%20%200pu…
NHP Species: marmosets
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tsinghua University; Chongqing Medical University; Boston University School of Medicine; Chinese Academy of Sciences; Shenzhen Bay Laboratory; Peking University Shenshen Graduate School; Fudan University
Keywords: SARS-CoV-2, pathogenesis, neutralization antibodies, primates
Summary of Study: Kappa, Delta, or B.1.618 spike uses human angiotensin-converting enzyme 2 (ACE2) with no or slightly increased efficiency, while it gains a significantly increased binding affinity with mouse, marmoset, and koala ACE2 orthologs, which exhibit limited binding with wild-type (WT) spike. Collectively, this study revealed that enhanced human and mouse ASE receptor engagement, increased spike cleavage, and reduced sensitivity to neutralization antibodies of Kapa, Delta and B.1.618 may contribute to the rapid spread of these variants.
References: PMID: 35266815 / doi: 10.1128/mbio.00099-22
Contact Info: Qiang Ding: qding@tsinghua.edu.cn
URL: https://journals.asm.org/doi/full/10.1128/mbio.00099-22?rfr_dat=cr_pub%20%200pu…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane School of Medicine
Keywords: SARS-CoV-2, monoclonal antibody prophylaxis, virus reproduction, primates
Summary of Study: High viral loads were observed in the intestinal mucosa of a rhesus macaque post challenge with SARS-CoV-2 after prophylactic administration of combination anti-spike antibody therapy. Intrahost evolution of virus was seen, with sequences changing in accordance with enhanced replication capacity, as well as site-specific differences potentially indicating preferential replication.
References: PMID: 35429402 / doi: 10.1093/infdis/jiac134
Contact Info: Chad Roy: croy@tulane.edu
URL: https://academic.oup.com/jid/article/226/9/1588/6569365?login=false
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane School of Medicine
Keywords: SARS-CoV-2, monoclonal antibody prophylaxis, virus reproduction, primates
Summary of Study: High viral loads were observed in the intestinal mucosa of a rhesus macaque post challenge with SARS-CoV-2 after prophylactic administration of combination anti-spike antibody therapy. Intrahost evolution of virus was seen, with sequences changing in accordance with enhanced replication capacity, as well as site-specific differences potentially indicating preferential replication.
References: PMID: 35429402 / doi: 10.1093/infdis/jiac134
Contact Info: Chad Roy: croy@tulane.edu
URL: https://academic.oup.com/jid/article/226/9/1588/6569365?login=false
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Universite Paris-Saclay, INSERM, CEA; Life and Soft; IRCCS Ospedale San Raffaele; Institut Pasteur
Keywords: SARS-CoV-2, neonate animals, immune response, pathology, primates
Summary of Study: This pilot study demonstrates that neonatal NHPs are a relevant model for pediatric SARS-CoV-2 infection.
References: PMID: 35603150 / doi: 10.3389/fimmu.2022.855230
Contact Info: Nabila Seddiki: nabila.seddiki@cea.fr
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.855230/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Universite Paris-Saclay, INSERM, CEA; Life and Soft; IRCCS Ospedale San Raffaele; Institut Pasteur
Keywords: SARS-CoV-2, neonate animals, immune response, pathology, primates
Summary of Study: This pilot study demonstrates that neonatal NHPs are a relevant model for pediatric SARS-CoV-2 infection.
References: PMID: 35603150 / doi: 10.3389/fimmu.2022.855230
Contact Info: Nabila Seddiki: nabila.seddiki@cea.fr
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.855230/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Tulane University School of Medicine; Beijing Forestry University; Beijing Institute of Lifeomics; Ochsner Clinic Foundation; University of Texas Southwestern Medical Center; Tulane National Primate Research Center
Keywords: SARS-CoV-2, peptide microarrays, neutralizing antibodies, vaccine, primates
Summary of Study: Linear peptide epitopes detected by immunoglobulins after infection have been localized to functionally important virus regions, which can be used to inform vaccine evaluation and targets for site-specific therapy.
References: PMID: 35928300 / doi: 10.34133/2022/9769803
Contact Info: Xiaobo Yu: yuxiaobo@mail.ncpsb.org; Tony Hu: tonyhu@tulane.edu
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297724/
NHP Species: african green monkeys, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Tulane University School of Medicine; Beijing Forestry University; Beijing Institute of Lifeomics; Ochsner Clinic Foundation; University of Texas Southwestern Medical Center; Tulane National Primate Research Center
Keywords: SARS-CoV-2, peptide microarrays, neutralizing antibodies, vaccine, primates
Summary of Study: Linear peptide epitopes detected by immunoglobulins after infection have been localized to functionally important virus regions, which can be used to inform vaccine evaluation and targets for site-specific therapy.
References: PMID: 35928300 / doi: 10.34133/2022/9769803
Contact Info: Xiaobo Yu: yuxiaobo@mail.ncpsb.org; Tony Hu: tonyhu@tulane.edu
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297724/
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Université Paris-Saclay; Université de Paris; Laboratoire de Pharmacocinétique et Toxicologie; Institut Pasteur; Centre International de Recherche en Infectiologie; Unité des Virus Emergents, Aix Marseille Univ; VirNext, Université Claude Bernard Lyon 1; University hopsital, Bordeaux & Inserm
Keywords: SARS-CoV-2, Zika, favipiravir, antiviral activity, primates
Summary of Study: A nucleoside analogue with activity against RNA viruses shows antiviral acitivty that reduces viral load and kinetics in Zika, but not COVID-19.
References: PMID: 36042198 / doi: 10.1038/s41467-022-32565-w
Contact Info: Roger Le Grand: roger.le-grand@cea.fr; Jeremie Guedj: jeremie.guedj@inserm.fr
URL: https://www.nature.com/articles/s41467-022-32565-w
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Université Paris-Saclay; Université de Paris; Laboratoire de Pharmacocinétique et Toxicologie; Institut Pasteur; Centre International de Recherche en Infectiologie; Unité des Virus Emergents, Aix Marseille Univ; VirNext, Université Claude Bernard Lyon 1; University hopsital, Bordeaux & Inserm
Keywords: SARS-CoV-2, Zika, favipiravir, antiviral activity, primates
Summary of Study: A nucleoside analogue with activity against RNA viruses shows antiviral acitivty that reduces viral load and kinetics in Zika, but not COVID-19.
References: PMID: 36042198 / doi: 10.1038/s41467-022-32565-w
Contact Info: Roger Le Grand: roger.le-grand@cea.fr; Jeremie Guedj: jeremie.guedj@inserm.fr
URL: https://www.nature.com/articles/s41467-022-32565-w
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shionogi & Co., Ltd., Biopharmaceutical Research Division, Osaka, Japan
Keywords: SARS-CoV-2, recombinant spike protein vaccine, virus variants, immune response
Summary of Study: Homologous and heterologous booster vaccinations of S-268019-b, a recombinant S protein-based vaccine
References: doi: 10.1016/j.vaccine.2022.10.092
Contact Info: Shinya Omoto: shinya.oomoto@shionogi.co.jp
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22013792?via%3Dihub=
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shionogi & Co., Ltd., Biopharmaceutical Research Division, Osaka, Japan
Keywords: SARS-CoV-2, recombinant spike protein vaccine, virus variants, immune response
Summary of Study: Homologous and heterologous booster vaccinations of S-268019-b, a recombinant S protein-based vaccine
References: doi: 10.1016/j.vaccine.2022.10.092
Contact Info: Shinya Omoto: shinya.oomoto@shionogi.co.jp
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22013792?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre/The Netherlands; NIAID; University Paris-Saclay, Inserm; Tulane National Primate Research Center; University of Pittsburgh School of Medicine; University of Pittsburgh Center for Vaccine Research; Texas Biomedical Research Institute; Frederick National Laboratory for Cancer Research
Keywords: SARS-CoV-2, advanced medical imaging, pathogenesis, primates
Summary of Study: The reviewers argue that advanced imaging tools add unique insight into poorly understood relationships of SARS-CV-2 exposure, infection, the host response, and disease presentation in the lungs.
References: PMID: 34955425 / doi: 10.1016/j.molmed.2021.12.001
Contact Info: Marieke Stammes: stammes@bprc.nl
URL: https://www.sciencedirect.com/science/article/pii/S1471491421003166?via%3Dihub=
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre/The Netherlands; NIAID; University Paris-Saclay, Inserm; Tulane National Primate Research Center; University of Pittsburgh School of Medicine; University of Pittsburgh Center for Vaccine Research; Texas Biomedical Research Institute; Frederick National Laboratory for Cancer Research
Keywords: SARS-CoV-2, advanced medical imaging, pathogenesis, primates
Summary of Study: The reviewers argue that advanced imaging tools add unique insight into poorly understood relationships of SARS-CV-2 exposure, infection, the host response, and disease presentation in the lungs.
References: PMID: 34955425 / doi: 10.1016/j.molmed.2021.12.001
Contact Info: Marieke Stammes: stammes@bprc.nl
URL: https://www.sciencedirect.com/science/article/pii/S1471491421003166?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Zhongshan School of Medicine; Qianyang Biomedical Research Institute; Guangdong Provincial Center for Disease Control and Prevention
Keywords: SARS-CoV-2, bivalent vaccine, D614G/B.1.351, vaccine dosage, mice, primates
Summary of Study: With a prime-boost or single-dose strategy a bivalent D614G/B.1.351 RBD nanoparticle vaccine elicited robust nAbs and full protection against infection with the authentic D614 or B.1.351 strains in human ACE2 transgene mice. Furthermore, 8 months after inoculation with the D614G-specific vaccine, a new boost with this bivalent vaccine potently elicited cross-nAbs for SARS-CoV-2 variants in rhesus macaques.
References: PMID: 34990583 / doi: 10.1016/j.celrep.2021.110256
Contact Info: Yiwen Zhang: zhangyw57@mail.sysu.edu.cn; Hui Zhang: zhangh92@mail.sysu.edu.cn
URL: https://www.sciencedirect.com/science/article/pii/S221112472101768X?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Zhongshan School of Medicine; Qianyang Biomedical Research Institute; Guangdong Provincial Center for Disease Control and Prevention
Keywords: SARS-CoV-2, bivalent vaccine, D614G/B.1.351, vaccine dosage, mice, primates
Summary of Study: With a prime-boost or single-dose strategy a bivalent D614G/B.1.351 RBD nanoparticle vaccine elicited robust nAbs and full protection against infection with the authentic D614 or B.1.351 strains in human ACE2 transgene mice. Furthermore, 8 months after inoculation with the D614G-specific vaccine, a new boost with this bivalent vaccine potently elicited cross-nAbs for SARS-CoV-2 variants in rhesus macaques.
References: PMID: 34990583 / doi: 10.1016/j.celrep.2021.110256
Contact Info: Yiwen Zhang: zhangyw57@mail.sysu.edu.cn; Hui Zhang: zhangh92@mail.sysu.edu.cn
URL: https://www.sciencedirect.com/science/article/pii/S221112472101768X?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Institute de Biologie Structurale; Universite Paris-Saclay, Inserm, CEA; Amsterdam University Medical Centers; Institute Pasteur, Universite de Paris; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, vaccine candidate, synthetic spike (S) glycoprotein-coated lipid vesicles, immune response, primates
Summary of Study: Immunization of cynomolgus macaques with S coated onto lipid vesicles (S-LVs) induces high antibody titers with potent neutralizing activity against the vaccine strain, Alpha, Beta, and Gamma variants as well as T helper (Th)1 CD4+-biased T cell responses.
References: PMID: 35233549 / doi: 10.1016/j.xcrm.2022.100528
Contact Info: Winfried Weissenhorn: winfried.weissenhorn@ibs.fr; Roger Le Grand: roger.le-grand@cea.fr
URL: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00028-3?_retu…
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Institute de Biologie Structurale; Universite Paris-Saclay, Inserm, CEA; Amsterdam University Medical Centers; Institute Pasteur, Universite de Paris; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, vaccine candidate, synthetic spike (S) glycoprotein-coated lipid vesicles, immune response, primates
Summary of Study: Immunization of cynomolgus macaques with S coated onto lipid vesicles (S-LVs) induces high antibody titers with potent neutralizing activity against the vaccine strain, Alpha, Beta, and Gamma variants as well as T helper (Th)1 CD4+-biased T cell responses.
References: PMID: 35233549 / doi: 10.1016/j.xcrm.2022.100528
Contact Info: Winfried Weissenhorn: winfried.weissenhorn@ibs.fr; Roger Le Grand: roger.le-grand@cea.fr
URL: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00028-3?_retu…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; China National Center for Bioinformation; Capital Medical University; Chinese Academy of Medical Sciences and Peking Union Medical College; Huazhong University of Science & Technology
Keywords: SARS-CoV-2, transcriptomic profiling, virus replication, primates
Summary of Study: This study provides the transcriptome profiling of various tissues from the living primate host post SARS-CoV-2 infection. It illustrates that wide-spread transcriptomic changes involving diverse functions exist in multi-organs; an elevated immune response in cerebral cortex was the prominent feature atth early stage of SARS-CoV-2 infection.
References: PMID: 35377064 / doi: 10.1007/s13238-022-00915-5
Contact Info: Ying Yang: yingyang@big.ac.cn; Yun-Gui Yang: ygyang@big.ac.cn; Chuan Qin: qinchuan@pumc.edu.cn; Wei-Min Tong: wmtong@ibms.pumc.edu.cn
URL: https://link.springer.com/article/10.1007/s13238-022-00915-5
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; China National Center for Bioinformation; Capital Medical University; Chinese Academy of Medical Sciences and Peking Union Medical College; Huazhong University of Science & Technology
Keywords: SARS-CoV-2, transcriptomic profiling, virus replication, primates
Summary of Study: This study provides the transcriptome profiling of various tissues from the living primate host post SARS-CoV-2 infection. It illustrates that wide-spread transcriptomic changes involving diverse functions exist in multi-organs; an elevated immune response in cerebral cortex was the prominent feature atth early stage of SARS-CoV-2 infection.
References: PMID: 35377064 / doi: 10.1007/s13238-022-00915-5
Contact Info: Ying Yang: yingyang@big.ac.cn; Yun-Gui Yang: ygyang@big.ac.cn; Chuan Qin: qinchuan@pumc.edu.cn; Wei-Min Tong: wmtong@ibms.pumc.edu.cn
URL: https://link.springer.com/article/10.1007/s13238-022-00915-5
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Sanofi R&D; Universite de Strasbourg; Equipe 3Bio
Keywords: SARS-CoV-2, mRNA vaccine, lipid nanoparticles, stability, mice, primates
Summary of Study: The thermostability of mRNA/LNP is improved by a novel imidazole modified lipid, DOG-IM4, in combination with standard helper lipids.
References: PMID: 35576809 / doi: 10.1016/j.biomaterials.2022.121570
Contact Info: Jean Haensler: jean.haensler@sanofi.com;
URL: https://www.sciencedirect.com/science/article/pii/S0142961222002101?via%3Dihub=
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Sanofi R&D; Universite de Strasbourg; Equipe 3Bio
Keywords: SARS-CoV-2, mRNA vaccine, lipid nanoparticles, stability, mice, primates
Summary of Study: The thermostability of mRNA/LNP is improved by a novel imidazole modified lipid, DOG-IM4, in combination with standard helper lipids.
References: PMID: 35576809 / doi: 10.1016/j.biomaterials.2022.121570
Contact Info: Jean Haensler: jean.haensler@sanofi.com;
URL: https://www.sciencedirect.com/science/article/pii/S0142961222002101?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Center for Genetic Engineering and Biotechnology, CIGB, Ave. 31 E/158 y 190, Havana 10600, Cuba
Keywords: SARS-CoV-2, chimeric antigen vaccine, immune response, mice, primates
Summary of Study: Fusion of SARS-CoV-2 receptor binding domain with the extracellular domain of human CD154 is a promising vaccine candidate
References: PMID: 35746505 PMCID: PMC9228316 DOI: 10.3390/vaccines10060897
Contact Info: Yamila Carpio and Mario Pablo Estrada: yamila.carpio@cigb.edu.cu; mario.pablo@cigb.edu.cu
URL: https://www.mdpi.com/2076-393X/10/6/897
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Center for Genetic Engineering and Biotechnology, CIGB, Ave. 31 E/158 y 190, Havana 10600, Cuba
Keywords: SARS-CoV-2, chimeric antigen vaccine, immune response, mice, primates
Summary of Study: Fusion of SARS-CoV-2 receptor binding domain with the extracellular domain of human CD154 is a promising vaccine candidate
References: PMID: 35746505 PMCID: PMC9228316 DOI: 10.3390/vaccines10060897
Contact Info: Yamila Carpio and Mario Pablo Estrada: yamila.carpio@cigb.edu.cu; mario.pablo@cigb.edu.cu
URL: https://www.mdpi.com/2076-393X/10/6/897
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Meissa Vaccines Inc; Bill & Melinda Gates Foundation; BIOQUAL Inc; Butler University; Vanderbilt University School of Medicine; University of Texas Medical Branch
Keywords: SARS-CoV-2, attenuated recombinant vaccine, immune response, primates
Summary of Study: A live, attenuated, recombinant human respiratory virus that expresses a chimeric SARS-CoV-2 spike protected against challenge and induced immunoglobulin and neutralizing antibodies.
References: PMID: 35906244 / doi: 10.1038/s41541-022-00509-6
Contact Info: Mariana F. Tioni: mariana.tioni@meissavaccines.com
URL: https://www.nature.com/articles/s41541-022-00509-6
NHP Species: marmosets
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Meissa Vaccines Inc; Bill & Melinda Gates Foundation; BIOQUAL Inc; Butler University; Vanderbilt University School of Medicine; University of Texas Medical Branch
Keywords: SARS-CoV-2, attenuated recombinant vaccine, immune response, primates
Summary of Study: A live, attenuated, recombinant human respiratory virus that expresses a chimeric SARS-CoV-2 spike protected against challenge and induced immunoglobulin and neutralizing antibodies.
References: PMID: 35906244 / doi: 10.1038/s41541-022-00509-6
Contact Info: Mariana F. Tioni: mariana.tioni@meissavaccines.com
URL: https://www.nature.com/articles/s41541-022-00509-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Veterinary and Animal Sciences, Pakistan
Keywords: SARS-CoV-2, iodine complexes, treatment, primates
Summary of Study: Iodine complexes have antiviral activity and help to clear coronavirus from monkeys, and Renessans with iodine complexes and ascorbic acid may provide an additive option for treatment.
References: PMID: 36143459; doi: 10.3390/life12091424
Contact Info: Tahir Yaqub: tahiryaqub@uvas.edu.pk
URL: https://www.mdpi.com/2075-1729/12/9/1424
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Veterinary and Animal Sciences, Pakistan
Keywords: SARS-CoV-2, iodine complexes, treatment, primates
Summary of Study: Iodine complexes have antiviral activity and help to clear coronavirus from monkeys, and Renessans with iodine complexes and ascorbic acid may provide an additive option for treatment.
References: PMID: 36143459; doi: 10.3390/life12091424
Contact Info: Tahir Yaqub: tahiryaqub@uvas.edu.pk
URL: https://www.mdpi.com/2075-1729/12/9/1424
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Chinese Academy of Sciences; State Key Laboratory of Respiratory Disease; Guangzhou Laboratory & Bioland Laboratory; Gangzhou nBiomed
Keywords: SARS-CoV-2, Ad5-vectored vaccine, SIV, immune response, primates
Summary of Study: Booster vaccination is required to elicit and maintain COVID-19 vaccine-induced immunity in SIV-infected macaques
References: doi: 10.1080/22221751.2022.2136538
Contact Info: Ling Chen: chen_ling@gibh.ac.cn
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2136538
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Chinese Academy of Sciences; State Key Laboratory of Respiratory Disease; Guangzhou Laboratory & Bioland Laboratory; Gangzhou nBiomed
Keywords: SARS-CoV-2, Ad5-vectored vaccine, SIV, immune response, primates
Summary of Study: Booster vaccination is required to elicit and maintain COVID-19 vaccine-induced immunity in SIV-infected macaques
References: doi: 10.1080/22221751.2022.2136538
Contact Info: Ling Chen: chen_ling@gibh.ac.cn
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2136538
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Beijing Institute for Brain Disorders, Capital Medical University, China; State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing , numerous others.
Keywords: SARS-CoV-2, single-nucleus transcriptomics, pathology, immune response, primates
Summary of Study: Single-nucleus transcriptomic profiling of multiple organs
References: doi: 10.24272/j.issn.2095-8137.2022.443
Contact Info: Xiaoqun Wang: nc.ude.unb@gnawnuqoaix
URL: https://www.zoores.ac.cn/en/article/doi/10.24272/j.issn.2095-8137.2022.443
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Beijing Institute for Brain Disorders, Capital Medical University, China; State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing , numerous others.
Keywords: SARS-CoV-2, single-nucleus transcriptomics, pathology, immune response, primates
Summary of Study: Single-nucleus transcriptomic profiling of multiple organs
References: doi: 10.24272/j.issn.2095-8137.2022.443
Contact Info: Xiaoqun Wang: nc.ude.unb@gnawnuqoaix
URL: https://www.zoores.ac.cn/en/article/doi/10.24272/j.issn.2095-8137.2022.443
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center, Texas Biomedical Research Institute; Washington University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, longitudinal scRNAseq, bronchoalveolar lavage, immune response, primates
Summary of Study: Results unequivocally show that in protected, immunocompetent hosts, SARS-CoV-2 infection is characterized by an acute inflammatory response leading to a myeloid cell influx into the lung compartment. Induction of a robust IFN response in macrophages strongly correlates with viremia and subsequent clearance of SARS-CoV-2 from the airways of macaques.
References: PMID: 35115549 / doi: 10.1038/s41467-022-28315-7
Contact Info: Maxim Artyomov: martyomov@wustl.edu
URL: https://www.nature.com/articles/s41467-022-28315-7
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center, Texas Biomedical Research Institute; Washington University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, longitudinal scRNAseq, bronchoalveolar lavage, immune response, primates
Summary of Study: Results unequivocally show that in protected, immunocompetent hosts, SARS-CoV-2 infection is characterized by an acute inflammatory response leading to a myeloid cell influx into the lung compartment. Induction of a robust IFN response in macrophages strongly correlates with viremia and subsequent clearance of SARS-CoV-2 from the airways of macaques.
References: PMID: 35115549 / doi: 10.1038/s41467-022-28315-7
Contact Info: Maxim Artyomov: martyomov@wustl.edu
URL: https://www.nature.com/articles/s41467-022-28315-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Sun Yat-sen University; Guangdong Academy of Medical Sciences; Qianyang Biomedical Research Institute; Guangdong Provincial Center for Disease Control and Prevention
Keywords: SARS-CoV-2, Receptor Binding Domain (RBD)-Conjugated Nanoparticle Vaccine, virus variants, hACE2 mice, primates
Summary of Study: RBD-based monovalent or multivalent nanoparticle vaccines provide a promising second-generation vaccine strategy for SARS-CoV-2 variants.
References: PMID: 35142444 / doi: 10.1002/advs.202105378
Contact Info: Ting Pan: pant8@gmail.sysu.edu.cn; Hui Zhang: zhangh92@mail.sysu.edu.cn
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008796/
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Sun Yat-sen University; Guangdong Academy of Medical Sciences; Qianyang Biomedical Research Institute; Guangdong Provincial Center for Disease Control and Prevention
Keywords: SARS-CoV-2, Receptor Binding Domain (RBD)-Conjugated Nanoparticle Vaccine, virus variants, hACE2 mice, primates
Summary of Study: RBD-based monovalent or multivalent nanoparticle vaccines provide a promising second-generation vaccine strategy for SARS-CoV-2 variants.
References: PMID: 35142444 / doi: 10.1002/advs.202105378
Contact Info: Ting Pan: pant8@gmail.sysu.edu.cn; Hui Zhang: zhangh92@mail.sysu.edu.cn
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008796/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Universite Paris-Saclay, Inserm, CEA; University of Amsterdam; Grousbeck Gene Therapy Center; Harvard Medical School; The Broad Institute of Harvard and MIT; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, computed X-ray tomography and [18F]-FDG positron emission tomography, pathology, primates
Summary of Study: CT, combined with [18F]-FDG PET imaging, to study SARS-CoV-2 infected NHPs, can produce strong and transposable readouts to moitor COVID-19 disease as well as the efficacy of future treatments and vaccine candidates.
References: PMID: 35313622 / doi: 10.1016/j.isci.2022.104101
Contact Info: Thibaut Naninck: thibaut.naninck@cea.fr
URL: https://www.cell.com/iscience/fulltext/S2589-0042(22)00371-6?_returnURL=https%3…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Universite Paris-Saclay, Inserm, CEA; University of Amsterdam; Grousbeck Gene Therapy Center; Harvard Medical School; The Broad Institute of Harvard and MIT; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, computed X-ray tomography and [18F]-FDG positron emission tomography, pathology, primates
Summary of Study: CT, combined with [18F]-FDG PET imaging, to study SARS-CoV-2 infected NHPs, can produce strong and transposable readouts to moitor COVID-19 disease as well as the efficacy of future treatments and vaccine candidates.
References: PMID: 35313622 / doi: 10.1016/j.isci.2022.104101
Contact Info: Thibaut Naninck: thibaut.naninck@cea.fr
URL: https://www.cell.com/iscience/fulltext/S2589-0042(22)00371-6?_returnURL=https%3…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of California, Davis, School of Medicine
Keywords: SARS-CoV-2, pre-existing HIV infection, gene expression, metabolomics, primates
Summary of Study: SIV infection resulted in sustained or increased ACE2 expression in an inflamed and immune-impaired gut mucosal microenvironment.
References: PMID: 35495669 / doi: 10.3389/fmicb.2022.879152
Contact Info: Satya Dandekar: sdandekar@ucdavis.edu
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2022.879152/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of California, Davis, School of Medicine
Keywords: SARS-CoV-2, pre-existing HIV infection, gene expression, metabolomics, primates
Summary of Study: SIV infection resulted in sustained or increased ACE2 expression in an inflamed and immune-impaired gut mucosal microenvironment.
References: PMID: 35495669 / doi: 10.3389/fmicb.2022.879152
Contact Info: Satya Dandekar: sdandekar@ucdavis.edu
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2022.879152/full
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Cellid Co., Ltd; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology; International Vaccine Institute; Seoul National University
Keywords: SARS-CoV-2, adenovirus, AdCLD-CoV19 vaccine, immune response, virus variants, primates
Summary of Study: AdCLD-CoV19 can prevent SARS-CoV-2 with a single vaccination, and the new vaccine administration strategy that responds to various variants can maintain the efficacy of the vaccine.
References: PMID: 35632468 / doi: 10.3390/vaccines10050712
Contact Info: Chang-Yuil Kang: cykang@snu.ac.kr
URL: https://www.mdpi.com/2076-393X/10/5/712
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Cellid Co., Ltd; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology; International Vaccine Institute; Seoul National University
Keywords: SARS-CoV-2, adenovirus, AdCLD-CoV19 vaccine, immune response, virus variants, primates
Summary of Study: AdCLD-CoV19 can prevent SARS-CoV-2 with a single vaccination, and the new vaccine administration strategy that responds to various variants can maintain the efficacy of the vaccine.
References: PMID: 35632468 / doi: 10.3390/vaccines10050712
Contact Info: Chang-Yuil Kang: cykang@snu.ac.kr
URL: https://www.mdpi.com/2076-393X/10/5/712