ORIP Fiscal Year 2025 State-of-the-Science Report

The National Institutes of Health (NIH) Office of Research Infrastructure Programs (ORIP) supports the national biomedical research community and NIH’s mission by providing a variety of research infrastructure and training programs that benefit human health both directly and indirectly. In recent years, ORIP has prioritized investment in critically needed cutting-edge biomedical infrastructure and resources to meet current and emerging challenges. ORIP’s two divisions, the Division of Comparative Medicine and the Division of Construction and Instruments, work closely together to ensure that their activities align with the office’s mission to provide infrastructure across the country to support research in all scientific disciplines. To that end, ORIP fosters collaborations, works to ensure rigor and reproducibility, enables gold-standard science, supports the development of and access to models and related biomedical resources, assists the research community in acquiring advanced scientific instrumentation, modernizes research facilities through physical infrastructure programs, provides specialized research training for biomedical scientists, and assists small businesses in developing new technologies.

ORIP leveraged resources to the fullest in fiscal year 2025 (FY25) to meet its mission and optimize infrastructure support to enhance the nation’s competitiveness in biomedical research. By establishing cofunding partnerships with 18 NIH institutes, centers, and offices, as well as with an NIH-wide initiative, ORIP was able to maximize its impact on research, further increase its broad array of resources, organize a series of focused sessions on cryopreservation, and finalize the research framework of the ORIP Strategic Plan 2026–2030. These efforts were in alignment with NIH’s key priority areas—such as chronic diseases research and new approach methodologies—among other crosscutting activities that support basic, translational, clinical, and behavioral research to advance knowledge on human health and diseases and ultimately enhance the health of all people. This state-of-the-science report highlights the many accomplishments and successes that ORIP achieved in FY25 in providing infrastructure for innovation for the nation’s biomedical research community.