Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Texas Medical Branch
Keywords: SARS-CoV-2, apoptosis, lung tissues, pathology, primates
Summary of Study: Significant increases in apoptotic signals in postmortem lung sections from COVID-19 patients and lungs of NHPs infected with SARS-CoV-2 on day 21 p.i.
References: PMID: 33922476 / doi: 10.3390/pathogens10050509
Contact Info: Paul Boor: pboor@utmb.edu; Jason Comer: jscomer@utmb.edu; Bin Gong: bigong@utmb.edu
URL: https://www.mdpi.com/2076-0817/10/5/509
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Texas Medical Branch
Keywords: SARS-CoV-2, apoptosis, lung tissues, pathology, primates
Summary of Study: Significant increases in apoptotic signals in postmortem lung sections from COVID-19 patients and lungs of NHPs infected with SARS-CoV-2 on day 21 p.i.
References: PMID: 33922476 / doi: 10.3390/pathogens10050509
Contact Info: Paul Boor: pboor@utmb.edu; Jason Comer: jscomer@utmb.edu; Bin Gong: bigong@utmb.edu
URL: https://www.mdpi.com/2076-0817/10/5/509
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Weill Cornell Medical College
Keywords: SARS-CoV-2, vaccines, antibody and T cell immunogenicity, review, primates
Summary of Study: This review article looks at what is known of the antibody and T cell immunogenicity of vaccines that have advanced to human clinical trials. Includes summary of press releases on the outcomes of vaccine efficacy trials.
References: PMID: 33608249 / doi: 10.1126/sciadv.abe8065
Contact Info: John P. Moore: jpm2003@med.cornell.edu
URL: https://advances.sciencemag.org/content/7/12/eabe8065
NHP Species: multiple species
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Weill Cornell Medical College
Keywords: SARS-CoV-2, vaccines, antibody and T cell immunogenicity, review, primates
Summary of Study: This review article looks at what is known of the antibody and T cell immunogenicity of vaccines that have advanced to human clinical trials. Includes summary of press releases on the outcomes of vaccine efficacy trials.
References: PMID: 33608249 / doi: 10.1126/sciadv.abe8065
Contact Info: John P. Moore: jpm2003@med.cornell.edu
URL: https://advances.sciencemag.org/content/7/12/eabe8065
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIH
Keywords: SARS-CoV-2, review, different primate species
Summary of Study: The authors advocate for baboons as a viable alternative to rhesus macaques in SARS-CoV-2 research.
References: PMID: 33785923 / doi:10.1038/s41684-021-00755-6
Contact Info: Michael Chang: changmic@mail.nih.gov
URL: https://www.nature.com/articles/s41684-021-00755-6
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIH
Keywords: SARS-CoV-2, review, different primate species
Summary of Study: The authors advocate for baboons as a viable alternative to rhesus macaques in SARS-CoV-2 research.
References: PMID: 33785923 / doi:10.1038/s41684-021-00755-6
Contact Info: Michael Chang: changmic@mail.nih.gov
URL: https://www.nature.com/articles/s41684-021-00755-6
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Shanghai Zerun Biotechnology Co., Ltd.; Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College; Shanghai Medical College, Fudan University; Wuhan University; National Institute for Food and Drug Control (NIFDC)
Keywords: SARS-CoV-2, recombinant vaccine, spike trimer, immunogenicity, mice, hamsters, primates
Summary of Study: A recombinant spike protein vaccine adjuvanted with aluminium hydroxide and CpG 7909 showed high immunogenicity and good protective efficacy in preclinical studies, supporting further clinical trials.
References: PMID: 34750014 / doi: 10.1016/j.vaccine.2021.10.066
Contact Info: Ge Liu: liuge@walvax.com; Jiangning Liu: liujn@cnilas.org.cn; Youhua Xie: yhxie@fudan.edu.cn; Zhongyu Hu: huzy67@163.com
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21013992?via%3Dihub=
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Shanghai Zerun Biotechnology Co., Ltd.; Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College; Shanghai Medical College, Fudan University; Wuhan University; National Institute for Food and Drug Control (NIFDC)
Keywords: SARS-CoV-2, recombinant vaccine, spike trimer, immunogenicity, mice, hamsters, primates
Summary of Study: A recombinant spike protein vaccine adjuvanted with aluminium hydroxide and CpG 7909 showed high immunogenicity and good protective efficacy in preclinical studies, supporting further clinical trials.
References: PMID: 34750014 / doi: 10.1016/j.vaccine.2021.10.066
Contact Info: Ge Liu: liuge@walvax.com; Jiangning Liu: liujn@cnilas.org.cn; Youhua Xie: yhxie@fudan.edu.cn; Zhongyu Hu: huzy67@163.com
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21013992?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Henry M. Jackson Foundation for the Advancement of Military Medicine; Washington University; National Cancer Institute/NIH; BIOQUAL; and others
Keywords: SARS-CoV-2, nanoparticle protein vaccine, humoral and cellular immune responses, primates
Summary of Study: Findings support the continued development of SARS-CoV-2 RBD ferritin nanoparticle vaccines (RFN) for managing COVID-19 and related SARS-CoV-like virus outbreaks.
References: PMID: 34470866 / doi: 10.1073/pnas.2106433118
Contact Info: Kayvon Modjarrad: kmodjarrad@eidresearch.org; Diane Bolton: dbolton@hivresearch.org
URL: https://www.pnas.org/content/118/38/e2106433118.long
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Henry M. Jackson Foundation for the Advancement of Military Medicine; Washington University; National Cancer Institute/NIH; BIOQUAL; and others
Keywords: SARS-CoV-2, nanoparticle protein vaccine, humoral and cellular immune responses, primates
Summary of Study: Findings support the continued development of SARS-CoV-2 RBD ferritin nanoparticle vaccines (RFN) for managing COVID-19 and related SARS-CoV-like virus outbreaks.
References: PMID: 34470866 / doi: 10.1073/pnas.2106433118
Contact Info: Kayvon Modjarrad: kmodjarrad@eidresearch.org; Diane Bolton: dbolton@hivresearch.org
URL: https://www.pnas.org/content/118/38/e2106433118.long
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences, Kunming Institute of Zoology; Institute of Infectious Diseases, Shenzhen Bay Laboratory; School of Medicine, Tsinghua University
Keywords: SARS-CoV-2, receptor-binding domain subunit vaccine, humoral and cellular immune responses, pathology, primates
Summary of Study: A trimeric SARS-CoV-2 receptor-binding domain (RBD) subunit vaccine that stimulates the natural structure of the spike (S) trimer glycoprotein is highly immunogenic and safe, providing long-lasting, broad, and significant immunity protection in NHPs. The vaccine-induced antibodies can effectively neutralize the SARS-CoV-2 501Y.V2 variant. A booster vaccination can quickly activate the memory immune response to avoid re-infection.
References: PMID: 34179862 / doi: 10.1016/j.xinn.2021.100140
Contact Info: Limin Yang: lmyang@im.ac.cn; Yong-tang Zheng: zhengyt@mail.kiz.ac.cn
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214323/
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences, Kunming Institute of Zoology; Institute of Infectious Diseases, Shenzhen Bay Laboratory; School of Medicine, Tsinghua University
Keywords: SARS-CoV-2, receptor-binding domain subunit vaccine, humoral and cellular immune responses, pathology, primates
Summary of Study: A trimeric SARS-CoV-2 receptor-binding domain (RBD) subunit vaccine that stimulates the natural structure of the spike (S) trimer glycoprotein is highly immunogenic and safe, providing long-lasting, broad, and significant immunity protection in NHPs. The vaccine-induced antibodies can effectively neutralize the SARS-CoV-2 501Y.V2 variant. A booster vaccination can quickly activate the memory immune response to avoid re-infection.
References: PMID: 34179862 / doi: 10.1016/j.xinn.2021.100140
Contact Info: Limin Yang: lmyang@im.ac.cn; Yong-tang Zheng: zhengyt@mail.kiz.ac.cn
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214323/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre (BPRC); Eurofins-INGENASA; Erasmus University Medical Center; Utrecht University
Keywords: SARS-CoV-2, post-acute phase, immune response, tomography, virus replication, primates
Summary of Study: NHPs infected with SARS-CoV-2 were followed for up to 6 weeks and monitored for COVID-19-like disease symptoms. Data indicate widespread tissue dissemination of SARS-CoV-2 in individual monkeys and provide evidence for continuing virus replication in lungs and surrounding lymph nodes after alleged convalescence of infection.
References: PMID: 34452537 / doi: 10.3390/v13081673
Contact Info: Ernst Verschoor: verschoor@bprc.nl
URL: https://www.mdpi.com/1999-4915/13/8/1673
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre (BPRC); Eurofins-INGENASA; Erasmus University Medical Center; Utrecht University
Keywords: SARS-CoV-2, post-acute phase, immune response, tomography, virus replication, primates
Summary of Study: NHPs infected with SARS-CoV-2 were followed for up to 6 weeks and monitored for COVID-19-like disease symptoms. Data indicate widespread tissue dissemination of SARS-CoV-2 in individual monkeys and provide evidence for continuing virus replication in lungs and surrounding lymph nodes after alleged convalescence of infection.
References: PMID: 34452537 / doi: 10.3390/v13081673
Contact Info: Ernst Verschoor: verschoor@bprc.nl
URL: https://www.mdpi.com/1999-4915/13/8/1673
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Battelle National Biodefense Institute; Gryphon Scientific LLC, Censeo Insight; Applied Research Associates
Keywords: SARS-CoV-2, inhalation, infection route, virus detection, dose response, primates
Summary of Study: SARS-CoV-2 infection and subsequent disease presentation are dependent on exposure dose in a nonhuman primate model of inhalational COVID-19.
References: PMID: 34424943 / doi: 10.1371/journal.ppat.1009865
Contact Info: Paul Dabisch: paul.dabisch@nbacc.dhs.gov
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009865
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Battelle National Biodefense Institute; Gryphon Scientific LLC, Censeo Insight; Applied Research Associates
Keywords: SARS-CoV-2, inhalation, infection route, virus detection, dose response, primates
Summary of Study: SARS-CoV-2 infection and subsequent disease presentation are dependent on exposure dose in a nonhuman primate model of inhalational COVID-19.
References: PMID: 34424943 / doi: 10.1371/journal.ppat.1009865
Contact Info: Paul Dabisch: paul.dabisch@nbacc.dhs.gov
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009865
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; Harvard T.H. Chan School of Public Health; Emory University; Moderna, Bioqual
Keywords: SARS-CoV-2, RNA-vaccine, immune response, virus replication, protection, primates
Summary of Study: Data establish that a two-dose regimen of mRNA-1273 (Moderna vaccine) will be critical for providing upper and lower airway protection against major varriants of concern.
References: PMID: 34417590 / doi: 10.1038/s41590-021-02021-0
Contact Info: Barney Graham: bgraham@nih.gov; Robert Seder: rseder@mail.nih.gov
URL: https://www.nature.com/articles/s41590-021-01021-0
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; Harvard T.H. Chan School of Public Health; Emory University; Moderna, Bioqual
Keywords: SARS-CoV-2, RNA-vaccine, immune response, virus replication, protection, primates
Summary of Study: Data establish that a two-dose regimen of mRNA-1273 (Moderna vaccine) will be critical for providing upper and lower airway protection against major varriants of concern.
References: PMID: 34417590 / doi: 10.1038/s41590-021-02021-0
Contact Info: Barney Graham: bgraham@nih.gov; Robert Seder: rseder@mail.nih.gov
URL: https://www.nature.com/articles/s41590-021-01021-0
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: The Wistar Institute, Perelman School of Medicine, NIAID, and others
Keywords: MERS-CoV, intradermal and intramuscular delivery, synthetic DNA vaccine, primates
Summary of Study: Results illustrate that a MERS spike antigen synthetic DNA vaccine administered in a 2-dose i.d. EP regimen can have positive impact in an important NHP challenge model protecting against symptoms and pathology.
References: PMID: 33886507 / doi: 10.1172/jci.insight.146082
Contact Info: David Weiner: dweiner@wistar.org
URL: https://insight.jci.org/articles/view/146082
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: The Wistar Institute, Perelman School of Medicine, NIAID, and others
Keywords: MERS-CoV, intradermal and intramuscular delivery, synthetic DNA vaccine, primates
Summary of Study: Results illustrate that a MERS spike antigen synthetic DNA vaccine administered in a 2-dose i.d. EP regimen can have positive impact in an important NHP challenge model protecting against symptoms and pathology.
References: PMID: 33886507 / doi: 10.1172/jci.insight.146082
Contact Info: David Weiner: dweiner@wistar.org
URL: https://insight.jci.org/articles/view/146082
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Public Health England & Welcome Trust Centre for Human Genetics
Keywords: SARS-CoV-2, pathogenicity, comparative studies, primates
Summary of Study: SARS-CoV-2 replicates in the upper and lower respiratory tract and causes pulmonary lesions in both rhesus and cynomolgus macaques. This provides convincing evidence that both macaque species authentically represent mild to moderate forms of COVID-19 observed in the majority of the human populations and both species can e used to evaluate the safety and efficacy of interventions proposed against SARS-CoV-2. Importantly, accessing cynomolgus macaques will greatly alleviate the pressures on current rhesus stocks.
References: PMID: 33627662 / doi: 10.1038/s41467-021-21389-9
Contact Info: Miles Carroll: miles.carroll@phe.gov.uk
URL: https://www.nature.com/articles/s41467-021-21389-9
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Public Health England & Welcome Trust Centre for Human Genetics
Keywords: SARS-CoV-2, pathogenicity, comparative studies, primates
Summary of Study: SARS-CoV-2 replicates in the upper and lower respiratory tract and causes pulmonary lesions in both rhesus and cynomolgus macaques. This provides convincing evidence that both macaque species authentically represent mild to moderate forms of COVID-19 observed in the majority of the human populations and both species can e used to evaluate the safety and efficacy of interventions proposed against SARS-CoV-2. Importantly, accessing cynomolgus macaques will greatly alleviate the pressures on current rhesus stocks.
References: PMID: 33627662 / doi: 10.1038/s41467-021-21389-9
Contact Info: Miles Carroll: miles.carroll@phe.gov.uk
URL: https://www.nature.com/articles/s41467-021-21389-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Wheaten College, Cornell University
Keywords: SARS-CoV-2, virus susceptibility, animal welfare, hamsters, ferrets, primates
Summary of Study: Paper reviews virus susceptibilities in species with frequent human contact, and factors that are best predictors of virus susceptibility.
References: PMID: 34359172 / doi: 10.3390/ani11072044
Contact Info: Kathleen Morgan: kmorgan@wheatoncollege.edu
URL: https://www.mdpi.com/2076-2615/11/7/2044
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Wheaten College, Cornell University
Keywords: SARS-CoV-2, virus susceptibility, animal welfare, hamsters, ferrets, primates
Summary of Study: Paper reviews virus susceptibilities in species with frequent human contact, and factors that are best predictors of virus susceptibility.
References: PMID: 34359172 / doi: 10.3390/ani11072044
Contact Info: Kathleen Morgan: kmorgan@wheatoncollege.edu
URL: https://www.mdpi.com/2076-2615/11/7/2044
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Beijing DanXu Biopharmaceuticals
Keywords: SARS-CoV-2, monoclonal antibody, ELISA assay, pharmacokinetic, primates
Summary of Study: In cynomolgus monkeys, BD-604 (a fully human monoclonal antibody) possesses pharmacokinetic properties similar to natural IgGs.
References: PMID: 34215019 / doi: 10.1002/dta.3122
Contact Info: Xu Zhang: janet_xu_zhang@singlomics.com
URL: https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/dta.3122
NHP Species:
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Beijing DanXu Biopharmaceuticals
Keywords: SARS-CoV-2, monoclonal antibody, ELISA assay, pharmacokinetic, primates
Summary of Study: In cynomolgus monkeys, BD-604 (a fully human monoclonal antibody) possesses pharmacokinetic properties similar to natural IgGs.
References: PMID: 34215019 / doi: 10.1002/dta.3122
Contact Info: Xu Zhang: janet_xu_zhang@singlomics.com
URL: https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/dta.3122
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences
Keywords: SARS-CoV-2, combined intratracheal and intranasal inoculation, primates
Summary of Study: The severity of respiratory tract infection enhanced air transmission and induced wide and severe SARS-CoV-2 infection in the lungs, suggesting the occurrence of more severe infectiousness and lung injury in SARS-CoV-2 patients with nasal infection.
References: PMID: 33587263 / doi: 10.1007/s11427-020-1877-4
Contact Info: Yong-Tang Zheng: zhengyt@mail.kiz.ac.cn
URL: https://link.springer.com/article/10.1007%2Fs11427-020-1877-4
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences
Keywords: SARS-CoV-2, combined intratracheal and intranasal inoculation, primates
Summary of Study: The severity of respiratory tract infection enhanced air transmission and induced wide and severe SARS-CoV-2 infection in the lungs, suggesting the occurrence of more severe infectiousness and lung injury in SARS-CoV-2 patients with nasal infection.
References: PMID: 33587263 / doi: 10.1007/s11427-020-1877-4
Contact Info: Yong-Tang Zheng: zhengyt@mail.kiz.ac.cn
URL: https://link.springer.com/article/10.1007%2Fs11427-020-1877-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID; Emory University Vaccine Center; BIOQUAL; Moderna; Johns Hopkins University
Keywords: SARS-CoV-2, variants of concern, booster, immune response, primates
Summary of Study: An additional, delayed boost with mRNA vaccines matched to either the original vaccine strain or to the heterologous challenge strain can have a marked and sustained effect on increaseing the breadth of neutralization against all VOCs tested and protection in both the lower and upper airways against the beta variant.
References: PMID: 34672695 / doi: 10.1126/science.abl8912
Contact Info: Robert Seder: rseder@mail.nih.gov; Barney Graham: bgraham@nih.gov
URL: https://www.science.org/doi/10.1126/science.abl8912?url_ver=Z39.88-2003&rfr_id=…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID; Emory University Vaccine Center; BIOQUAL; Moderna; Johns Hopkins University
Keywords: SARS-CoV-2, variants of concern, booster, immune response, primates
Summary of Study: An additional, delayed boost with mRNA vaccines matched to either the original vaccine strain or to the heterologous challenge strain can have a marked and sustained effect on increaseing the breadth of neutralization against all VOCs tested and protection in both the lower and upper airways against the beta variant.
References: PMID: 34672695 / doi: 10.1126/science.abl8912
Contact Info: Robert Seder: rseder@mail.nih.gov; Barney Graham: bgraham@nih.gov
URL: https://www.science.org/doi/10.1126/science.abl8912?url_ver=Z39.88-2003&rfr_id=…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Amsterdam; INSERM, CEA; National Institute for Public Health and the Environment, RIVM; Public Health Service of Amsterdam; Tergooi Hospital; Amsterdam Neuroscience, AMC; Amsterdam Infectoin & Immunity, AMC; Amsterdam Infection & Immunity, VUmc; The University of Melbourne; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, cross-reactive antibodies, human coronaviruses, primates
Summary of Study: The results from this study on the presence and specificity of cross-reactive antibodies to other hCoVs after SARS-CoV-2 infection and vaccination emphasize the feasibility of broad coronavirus vaccines and may guide future vaccine designs.
References: PMID: 34812143 / doi: 10.7554/eLife.70330
Contact Info: Marit J van Gils: m.j.vangils@amsterdamumc.nl
URL: https://elifesciences.org/articles/70330
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Amsterdam; INSERM, CEA; National Institute for Public Health and the Environment, RIVM; Public Health Service of Amsterdam; Tergooi Hospital; Amsterdam Neuroscience, AMC; Amsterdam Infectoin & Immunity, AMC; Amsterdam Infection & Immunity, VUmc; The University of Melbourne; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, cross-reactive antibodies, human coronaviruses, primates
Summary of Study: The results from this study on the presence and specificity of cross-reactive antibodies to other hCoVs after SARS-CoV-2 infection and vaccination emphasize the feasibility of broad coronavirus vaccines and may guide future vaccine designs.
References: PMID: 34812143 / doi: 10.7554/eLife.70330
Contact Info: Marit J van Gils: m.j.vangils@amsterdamumc.nl
URL: https://elifesciences.org/articles/70330
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences, National Institute of Food and Drug Control (Beijing, China), Yunnan Provincial Infectious Disease Hospital, Yunnan Center for Disease Control and Prevention, Kunming Third People's Hospital
Keywords: SARS-CoV-2, inactivated virus vaccine, immune response, pathology, mice, primates
Summary of Study: Inactivated SARS-CoV-2 vaccine, produced by sequential inactivation with formaldehyde followed by propiolactone, was shown to be effective against SARS-Co-V 2 challenge in rhesus macaques.
References: PMID: 34462721 / doi: 10.1016/j.omtm.2021.08.005
Contact Info: Changgui Li: changguili@aliyun.com; Qihan Li: liqihan@imbcams.com.cn; Longding Liu: liuld@imbcams.com.cn
URL: https://www.sciencedirect.com/science/article/pii/S2329050121001315?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences, National Institute of Food and Drug Control (Beijing, China), Yunnan Provincial Infectious Disease Hospital, Yunnan Center for Disease Control and Prevention, Kunming Third People's Hospital
Keywords: SARS-CoV-2, inactivated virus vaccine, immune response, pathology, mice, primates
Summary of Study: Inactivated SARS-CoV-2 vaccine, produced by sequential inactivation with formaldehyde followed by propiolactone, was shown to be effective against SARS-Co-V 2 challenge in rhesus macaques.
References: PMID: 34462721 / doi: 10.1016/j.omtm.2021.08.005
Contact Info: Changgui Li: changguili@aliyun.com; Qihan Li: liqihan@imbcams.com.cn; Longding Liu: liuld@imbcams.com.cn
URL: https://www.sciencedirect.com/science/article/pii/S2329050121001315?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Tehran, Tabriz University of Medical Sciences, Karolinska Institute, University of Rochester Medical Center, Toyko University of Science, University of Veterinary Medicine (Vienna)
Keywords: SARS-CoV-2, immune response, reinfection, recovery, primates
Summary of Study: Review paper proposing a new strategy to predict the potential of reinfection in each identified category. This classification may help to distribute resources more meticulously to determine: Who needs to be serologically tested for SARS-CoV-2 neutralizing antibodies, what percentage of the population is immune to the virus, and who needs to be vaccinated.
References: PMID: 33520309 / doi: 10.1016/jare.2020.12.013
Contact Info: Younes Aftabi: aftably@tbzmed.ac.ir; Sasan Fereidouni: sasan.fereidouni@vetmeduni.ac.at
URL: https://www.sciencedirect.com/science/article/pii/S2090123220302630?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Tehran, Tabriz University of Medical Sciences, Karolinska Institute, University of Rochester Medical Center, Toyko University of Science, University of Veterinary Medicine (Vienna)
Keywords: SARS-CoV-2, immune response, reinfection, recovery, primates
Summary of Study: Review paper proposing a new strategy to predict the potential of reinfection in each identified category. This classification may help to distribute resources more meticulously to determine: Who needs to be serologically tested for SARS-CoV-2 neutralizing antibodies, what percentage of the population is immune to the virus, and who needs to be vaccinated.
References: PMID: 33520309 / doi: 10.1016/jare.2020.12.013
Contact Info: Younes Aftabi: aftably@tbzmed.ac.ir; Sasan Fereidouni: sasan.fereidouni@vetmeduni.ac.at
URL: https://www.sciencedirect.com/science/article/pii/S2090123220302630?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Shanghai Jemincare Pharmaceuticals Co.; Chinese Academy of Sciences; tongji Medical College of Huazhong University of Science & Technology
Keywords: SARS-CoV-2, neutralizing antibodies, immune response, primates
Summary of Study: Two potent nABs against SARS-CoV-2 from naive phage-displayed human B cell single-chain variable fragment libraries were identified. One, JMB2002) not only showed potent in vitro blocking activity against a broad-spectrum of SARS-CoV-2 variants including the B.1.351 lineage, but also potent therapeutic efficacy and complete prophylactic protection against SARS-CoV-2 in a rhesus macaque infection model. Prophylactic and therapeutic countermeasure intervention of SARS-CoV-2 using antibody JMB2002 would likely slow down the transmission of currently emerged SARS-CoV-2 variants and result in more efficient control of the COVID-19 pandemic.
References: PMID: 34097570 / doi: 10.1080/19420862.2021.1930636
Contact Info: Su-Jun Deng: dengsujun@jemincare.com; Wuxiang Guan: guanwx@wh.iov.cn; Zhiming Yuan: yzm@wh.iov.cn
URL: https://www.tandfonline.com/doi/full/10.1080/19420862.2021.1930636
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Shanghai Jemincare Pharmaceuticals Co.; Chinese Academy of Sciences; tongji Medical College of Huazhong University of Science & Technology
Keywords: SARS-CoV-2, neutralizing antibodies, immune response, primates
Summary of Study: Two potent nABs against SARS-CoV-2 from naive phage-displayed human B cell single-chain variable fragment libraries were identified. One, JMB2002) not only showed potent in vitro blocking activity against a broad-spectrum of SARS-CoV-2 variants including the B.1.351 lineage, but also potent therapeutic efficacy and complete prophylactic protection against SARS-CoV-2 in a rhesus macaque infection model. Prophylactic and therapeutic countermeasure intervention of SARS-CoV-2 using antibody JMB2002 would likely slow down the transmission of currently emerged SARS-CoV-2 variants and result in more efficient control of the COVID-19 pandemic.
References: PMID: 34097570 / doi: 10.1080/19420862.2021.1930636
Contact Info: Su-Jun Deng: dengsujun@jemincare.com; Wuxiang Guan: guanwx@wh.iov.cn; Zhiming Yuan: yzm@wh.iov.cn
URL: https://www.tandfonline.com/doi/full/10.1080/19420862.2021.1930636
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NCI, Frederick National Laboratory for Cancer Research, BIOQUAL, University of Athens School of Medicine, University of Washington
Keywords: SARS-CoV-2, DNA-based vaccine, immune response, primates
Summary of Study: A vaccine regimen comprising simultaneous co-immunization of DNA and Protein at the same anatomical site showed best neutralizing abilities and was more effective than DNA alone in inducing protective immune responses and controlling SARS-CoV-2 infection. An expansion of the DNA vaccine regimen to include co-immunization with Spike protein may be of advantage for SARS-CoV-2.
References: PMID: 34551020 / doi: 10.1371/journal.ppat.1009701
Contact Info: Barbara Felber: barbara.felber@nih.gov
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009701
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NCI, Frederick National Laboratory for Cancer Research, BIOQUAL, University of Athens School of Medicine, University of Washington
Keywords: SARS-CoV-2, DNA-based vaccine, immune response, primates
Summary of Study: A vaccine regimen comprising simultaneous co-immunization of DNA and Protein at the same anatomical site showed best neutralizing abilities and was more effective than DNA alone in inducing protective immune responses and controlling SARS-CoV-2 infection. An expansion of the DNA vaccine regimen to include co-immunization with Spike protein may be of advantage for SARS-CoV-2.
References: PMID: 34551020 / doi: 10.1371/journal.ppat.1009701
Contact Info: Barbara Felber: barbara.felber@nih.gov
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009701
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: King Mongkut's University of Technology; Chulalongkorn University; Mahidol University; B.F. Feed Company, Ltd.
Keywords: SARS-CoV-2, spike receptor-binding domain, immunization, convalescent sera, B-cell epitopes, primates
Summary of Study: The immunoinformatics method described could be a useful tool for identification of antibody epitopes in new virus variants and also other target proteins.
References: PMID: 34650130 / doi: 10.1038/s41598-021-99642-w
Contact Info: Yaowaluck Mapring Roshorm: yaowaluck.ros@kmutt.ac.th
URL: https://www.nature.com/articles/s41598-021-99642-w
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: King Mongkut's University of Technology; Chulalongkorn University; Mahidol University; B.F. Feed Company, Ltd.
Keywords: SARS-CoV-2, spike receptor-binding domain, immunization, convalescent sera, B-cell epitopes, primates
Summary of Study: The immunoinformatics method described could be a useful tool for identification of antibody epitopes in new virus variants and also other target proteins.
References: PMID: 34650130 / doi: 10.1038/s41598-021-99642-w
Contact Info: Yaowaluck Mapring Roshorm: yaowaluck.ros@kmutt.ac.th
URL: https://www.nature.com/articles/s41598-021-99642-w
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: National Institute of Infectious Diseases, Japan; University of Tokyo; Kumamoto University, and others
Keywords: SARS-CoV-2, virus-specific CD8+ T-cell responses, virus replication, immune response, primates
Summary of Study: The effect of CD8+ cell depletion on SARS-CoV-2 replication when monoclonal anti-CD8 antibody is administered in the subacute phase was studied in cynomolgus macaques. Analysis revealed no significant impact of CD8+ cell depletion on viral replication, indicating the subacute SARS-CoV-2 replication can be controlled in the absence of CD8+ T cells.
References: PMID: 34280241 / doi: 10.1371/journal.ppat.1009668
Contact Info: Tetsuro Matano: tmatano@nih.go.jp; Takushi Nomura: nomutaku@nih.go.jp
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009668
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: National Institute of Infectious Diseases, Japan; University of Tokyo; Kumamoto University, and others
Keywords: SARS-CoV-2, virus-specific CD8+ T-cell responses, virus replication, immune response, primates
Summary of Study: The effect of CD8+ cell depletion on SARS-CoV-2 replication when monoclonal anti-CD8 antibody is administered in the subacute phase was studied in cynomolgus macaques. Analysis revealed no significant impact of CD8+ cell depletion on viral replication, indicating the subacute SARS-CoV-2 replication can be controlled in the absence of CD8+ T cells.
References: PMID: 34280241 / doi: 10.1371/journal.ppat.1009668
Contact Info: Tetsuro Matano: tmatano@nih.go.jp; Takushi Nomura: nomutaku@nih.go.jp
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009668
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences; Peking Union Medical College; Capital Medical University
Keywords: SARS-CoV-2, pathology, myocardial injury, differential expression, primates
Summary of Study: SARS-CoV-2 infected rhesus macaques showed viral myocarditis, where inflammation and endothelial injury jointly resulted in cardiac damage.
References: PMID: 34489396 / doi: 10.1038/s413392-021-00747-5
Contact Info: Jiangning Liu: liujn@cnilas.org; Jing Wang: wangjing@ibms.pumc.edu.cn
URL: https://www.nature.com/articles/s41392-021-00747-5
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences; Peking Union Medical College; Capital Medical University
Keywords: SARS-CoV-2, pathology, myocardial injury, differential expression, primates
Summary of Study: SARS-CoV-2 infected rhesus macaques showed viral myocarditis, where inflammation and endothelial injury jointly resulted in cardiac damage.
References: PMID: 34489396 / doi: 10.1038/s413392-021-00747-5
Contact Info: Jiangning Liu: liujn@cnilas.org; Jing Wang: wangjing@ibms.pumc.edu.cn
URL: https://www.nature.com/articles/s41392-021-00747-5
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Harvard Univ., MIT, Tulane National Primate Research Center
Keywords: SARS-CoV-2, respiratory droplet generation and exhalation, primates
Summary of Study: The proportion of small respiratory droplets (the majority of particles exhaled in all subjects) increased at the peak of COVID-19 infection in NHPs. This confirms a previously published observation from the exhaled aerosol profile of a single COVID-19 positive human subject, and suggests that, at peak infection, there may be an elevated risk of the airborne transmission of SARS-CoV-2 by way of the very small droplets that transmit through conventional masks and travers distances far exceeding the conventional social distance of 2 m.
References: PMID: 33563754 / doi: 10.1073/pnas.2021830118
Contact Info: David Edwards: dedwards@seas.harvard.edu; Chad Roy: croy@tulane.edu
URL: https://www.pnas.org/content/118/8/e2021830118.long
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Harvard Univ., MIT, Tulane National Primate Research Center
Keywords: SARS-CoV-2, respiratory droplet generation and exhalation, primates
Summary of Study: The proportion of small respiratory droplets (the majority of particles exhaled in all subjects) increased at the peak of COVID-19 infection in NHPs. This confirms a previously published observation from the exhaled aerosol profile of a single COVID-19 positive human subject, and suggests that, at peak infection, there may be an elevated risk of the airborne transmission of SARS-CoV-2 by way of the very small droplets that transmit through conventional masks and travers distances far exceeding the conventional social distance of 2 m.
References: PMID: 33563754 / doi: 10.1073/pnas.2021830118
Contact Info: David Edwards: dedwards@seas.harvard.edu; Chad Roy: croy@tulane.edu
URL: https://www.pnas.org/content/118/8/e2021830118.long
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Karolinska Institutet; University of Cape Town
Keywords: SARS-CoV-2, virus genomic variants, antigenic sin, boost, passive immunization, mice, primates
Summary of Study: A single dose of adjuvanted beta variant receptor binding domain (RBD) protein broadens neutralizing antibody responses to heterologous VOCs.
References: PMID: 34723224 / doi: 10.1016/j.xcrm.2021.100450
Contact Info: Daniel Sheward: daniel.sheward@ki.se; Gunilla Karlsson Hedestam: gunilla.karlsson.hedestam@ki.se; Ben Murrell: benjamin.murrell@ki.se
URL: https://www.sciencedirect.com/science/article/pii/S2666379121003189?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Karolinska Institutet; University of Cape Town
Keywords: SARS-CoV-2, virus genomic variants, antigenic sin, boost, passive immunization, mice, primates
Summary of Study: A single dose of adjuvanted beta variant receptor binding domain (RBD) protein broadens neutralizing antibody responses to heterologous VOCs.
References: PMID: 34723224 / doi: 10.1016/j.xcrm.2021.100450
Contact Info: Daniel Sheward: daniel.sheward@ki.se; Gunilla Karlsson Hedestam: gunilla.karlsson.hedestam@ki.se; Ben Murrell: benjamin.murrell@ki.se
URL: https://www.sciencedirect.com/science/article/pii/S2666379121003189?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Copycat Sciences; Sporos Bioventures
Keywords: SARS-CoV-2, redelivery, analysis of the preclinical data and clinical efficacy, primates
Summary of Study: The gap between the strong preclinical data with remdesivir (RDV) across many virus models and its questionable clinical activitiy suggests that assumptions are being made at the preclinical level that do not reflect the conditions observed in patients.
References: PMID: 34252308 / doi: 10.1128/AAC.01117-21
Contact Info: Victoria Yan: victoria.yan@copycatsciences.com
URL: https://journals.asm.org/doi/10.1128/AAC.01117-21?url_ver=Z39.88-2003&rfr_id=or…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Copycat Sciences; Sporos Bioventures
Keywords: SARS-CoV-2, redelivery, analysis of the preclinical data and clinical efficacy, primates
Summary of Study: The gap between the strong preclinical data with remdesivir (RDV) across many virus models and its questionable clinical activitiy suggests that assumptions are being made at the preclinical level that do not reflect the conditions observed in patients.
References: PMID: 34252308 / doi: 10.1128/AAC.01117-21
Contact Info: Victoria Yan: victoria.yan@copycatsciences.com
URL: https://journals.asm.org/doi/10.1128/AAC.01117-21?url_ver=Z39.88-2003&rfr_id=or…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: USC, , UCLA, City of Hope, Bioqual
Keywords: SARS-CoV-2, pancreatic beta cells, toxicity, metabolism, primates
Summary of Study: SARS-CoV-2 infection enhances beta cell stress that may compromise beta-cell function beyond the duration of the disease course, raising the possibility that the beta cell stress and injury may have clinical implications to the long-term future health of patients that have recovered from COVID19.
References: PMID: 34312617 / doi: 10.21203/rs.3.rs-592374/v1
Contact Info: Senta Georgia: sgeorgia@chla.usc.edu
URL: https://www.researchsquare.com/article/rs-592374/v1
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: USC, , UCLA, City of Hope, Bioqual
Keywords: SARS-CoV-2, pancreatic beta cells, toxicity, metabolism, primates
Summary of Study: SARS-CoV-2 infection enhances beta cell stress that may compromise beta-cell function beyond the duration of the disease course, raising the possibility that the beta cell stress and injury may have clinical implications to the long-term future health of patients that have recovered from COVID19.
References: PMID: 34312617 / doi: 10.21203/rs.3.rs-592374/v1
Contact Info: Senta Georgia: sgeorgia@chla.usc.edu
URL: https://www.researchsquare.com/article/rs-592374/v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Weill Cornell Medical College
Keywords: SARS-CoV-2, antibody and T cell immunogenicity, testing vaccines in humans and primates, review
Summary of Study: This review article summaries what is known of the antibody and T cell immunogenicity of multiple preventive vaccines in NHPs and humans.
References: PMID: 33608249 / doi: 10.1126/sciadv.abe8065
Contact Info: John Moore: jpm2003@med.cornell.edu
URL: https://advances.sciencemag.org/content/7/12/eabe8065
NHP Species: multiple species
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Weill Cornell Medical College
Keywords: SARS-CoV-2, antibody and T cell immunogenicity, testing vaccines in humans and primates, review
Summary of Study: This review article summaries what is known of the antibody and T cell immunogenicity of multiple preventive vaccines in NHPs and humans.
References: PMID: 33608249 / doi: 10.1126/sciadv.abe8065
Contact Info: John Moore: jpm2003@med.cornell.edu
URL: https://advances.sciencemag.org/content/7/12/eabe8065
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Henry M. Jackson Foundation for the Advancement of Military Medicine; Washington University; NCI/NIH; BIOQUAL; Texas Biomedical Research Institute; Columbia University Vagelos College of Physicians and Surgeons.
Keywords: SARS-CoV-2, nanoparticle protein vaccine, humoral and cellular immune responses, virus variants, primates
Summary of Study: A ferritin nanoparticle vaccine displaying the receptor-binding domain of the SARS-CoV-2 spike protein adjuvanted with Army Liposomal Formulation QS-21 induces robust and broad antibody and T cell responses, as well as protection against viral replication and lung pathology following high-dose respiratory tract challenge with SARS-CoV-2.
References: PMID: 34470866 / doi: 10.1073/pnas.2106433118
Contact Info: Kayvon Modjarrad: kmodjarrad@eidresearch.org; Diane Bolton: dbolton@hivresearch.org
URL: https://www.pnas.org/content/118/38/e2106433118.long
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Henry M. Jackson Foundation for the Advancement of Military Medicine; Washington University; NCI/NIH; BIOQUAL; Texas Biomedical Research Institute; Columbia University Vagelos College of Physicians and Surgeons.
Keywords: SARS-CoV-2, nanoparticle protein vaccine, humoral and cellular immune responses, virus variants, primates
Summary of Study: A ferritin nanoparticle vaccine displaying the receptor-binding domain of the SARS-CoV-2 spike protein adjuvanted with Army Liposomal Formulation QS-21 induces robust and broad antibody and T cell responses, as well as protection against viral replication and lung pathology following high-dose respiratory tract challenge with SARS-CoV-2.
References: PMID: 34470866 / doi: 10.1073/pnas.2106433118
Contact Info: Kayvon Modjarrad: kmodjarrad@eidresearch.org; Diane Bolton: dbolton@hivresearch.org
URL: https://www.pnas.org/content/118/38/e2106433118.long
Coronavirus Investigated: SARS-CoV-2
NHP Species: macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Institute for Basic Science (IBS) (Repblic of Kores), Eulji University School of Medicine, Seol National University Hospital, Jeonbuk National University Medical School, Sungkyunkwan University School of Medicine
Keywords: SARS-CoV-2, nasal ciliated cells, virus tropism, primates
Summary of Study: Nasal multiciliated epithelial cells are th emain target for SARS-CoV-2 infection and replication in the upper airway during the early stages of COVID-19, implying that targeting nasal ciliated cells could be an ideal strategy to prevent SARS-CoV-2 propagation.
References: PMID: 34003804 / doi: 10.1172/JCI148517
Contact Info: Ji Hoon Ahn: ahnadun@kaist.ac.kr; JungMo Kim: jmkim@ibs.re.kr; Seon Pyo Hong: sp_hong@kaist.ac.kr; Young Tae Kim: ytkim@snu.ac.kr, Chang-Seop Lee: lcsmd@jbnu.ac.kr
URL: https://www.jci.org/articles/view/148517
NHP Species: macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Institute for Basic Science (IBS) (Repblic of Kores), Eulji University School of Medicine, Seol National University Hospital, Jeonbuk National University Medical School, Sungkyunkwan University School of Medicine
Keywords: SARS-CoV-2, nasal ciliated cells, virus tropism, primates
Summary of Study: Nasal multiciliated epithelial cells are th emain target for SARS-CoV-2 infection and replication in the upper airway during the early stages of COVID-19, implying that targeting nasal ciliated cells could be an ideal strategy to prevent SARS-CoV-2 propagation.
References: PMID: 34003804 / doi: 10.1172/JCI148517
Contact Info: Ji Hoon Ahn: ahnadun@kaist.ac.kr; JungMo Kim: jmkim@ibs.re.kr; Seon Pyo Hong: sp_hong@kaist.ac.kr; Young Tae Kim: ytkim@snu.ac.kr, Chang-Seop Lee: lcsmd@jbnu.ac.kr
URL: https://www.jci.org/articles/view/148517
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Universite Paris-Saclay/Inserm/CEA; Vaccine Research INstitute, Creteil, France; Inserm; Baylor Scott and White Research Institute; Institut Pasteur; Karolinska Institutet; and others
Keywords: SARS-CoV-2, subunit vaccine, receptor-binding domain, immune response, humanized mice, primates
Summary of Study: A single dose of the alphaCD40.RBD (a vaccine that targets the receptor-binding domain of the SARS-CoV-2 spike antigen to the CD40 receptor) administered without adjuvant boosts the protective response in COVID-10 convalescent NHPs.
References: PMID: 34471122 / doi: 10.1038/s41467-021-25382-0
Contact Info: Yves Levy: yves.levy@inserm.fr
URL: https://www.nature.com/articles/s41467-021-25382-0
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Universite Paris-Saclay/Inserm/CEA; Vaccine Research INstitute, Creteil, France; Inserm; Baylor Scott and White Research Institute; Institut Pasteur; Karolinska Institutet; and others
Keywords: SARS-CoV-2, subunit vaccine, receptor-binding domain, immune response, humanized mice, primates
Summary of Study: A single dose of the alphaCD40.RBD (a vaccine that targets the receptor-binding domain of the SARS-CoV-2 spike antigen to the CD40 receptor) administered without adjuvant boosts the protective response in COVID-10 convalescent NHPs.
References: PMID: 34471122 / doi: 10.1038/s41467-021-25382-0
Contact Info: Yves Levy: yves.levy@inserm.fr
URL: https://www.nature.com/articles/s41467-021-25382-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School, University of North Carolina at Chapel Hill, Ragon Institute of MGH, MIT, and Harvard, Massachusetts Consortium on Pathogen Readiness
Keywords: SARS-CoV-2, adenovirus vaccine, immunogenicity and protective efficacy, mice
Summary of Study: RhAd52 vaccines elicit robust SARS-CoV-2 specific antibody responses and protect against clinical disease and viral replication in the lungs. These data validate the MA10 mouse model as a useful tool to screen and study novel vaccine candidates, as well as the development of RhAd52 vaccines for COVID-19.
References: PMID: 34523968 / doi: 10.1128/JVI.00974-21
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://journals.asm.org/doi/10.1128/JVI.00974-21?url_ver=Z39.88-2003&rfr_id=or…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School, University of North Carolina at Chapel Hill, Ragon Institute of MGH, MIT, and Harvard, Massachusetts Consortium on Pathogen Readiness
Keywords: SARS-CoV-2, adenovirus vaccine, immunogenicity and protective efficacy, mice
Summary of Study: RhAd52 vaccines elicit robust SARS-CoV-2 specific antibody responses and protect against clinical disease and viral replication in the lungs. These data validate the MA10 mouse model as a useful tool to screen and study novel vaccine candidates, as well as the development of RhAd52 vaccines for COVID-19.
References: PMID: 34523968 / doi: 10.1128/JVI.00974-21
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://journals.asm.org/doi/10.1128/JVI.00974-21?url_ver=Z39.88-2003&rfr_id=or…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Wisconsin National Primate Research Center, Harvard Medical School, Tufts University, BIOQUAL, Ragon Institute of MGH, MIT and Harvard
Keywords: SARS-CoV-2, prior infection, vaccination, virus variants, protection, hamsters, primates
Summary of Study: Data suggest partial but reduced short-term protective efficacy of WA1/2020 natural immunity against SARS-CoV-2 variants of concern. More research is needed to define protective efficacy against other SARS-CoV-2 variants and the immunologic mechanisms of protection against these variants.
References: PMID: 34546094 / doi: 10.1126/scitranslmed.abj2641
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.science.org/doi/10.1126/scitranslmed.abj2641?url_ver=Z39.88-2003&rf…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Wisconsin National Primate Research Center, Harvard Medical School, Tufts University, BIOQUAL, Ragon Institute of MGH, MIT and Harvard
Keywords: SARS-CoV-2, prior infection, vaccination, virus variants, protection, hamsters, primates
Summary of Study: Data suggest partial but reduced short-term protective efficacy of WA1/2020 natural immunity against SARS-CoV-2 variants of concern. More research is needed to define protective efficacy against other SARS-CoV-2 variants and the immunologic mechanisms of protection against these variants.
References: PMID: 34546094 / doi: 10.1126/scitranslmed.abj2641
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.science.org/doi/10.1126/scitranslmed.abj2641?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Battelle National Biodefense Institute; Gryphon Scientific LLC; Censeo Insight; Applied Research Associates
Keywords: SARS-CoV-2, inhalation, seroconversion, fever, dose response, primates
Summary of Study: SARS-CoV-2 infection and subsequent disease presentation are dependent on exposure dose in a nonhuman primate model of inhalational COVID-19.
References: PMID: 34424943 / doi: 10.1371/journal.ppat.1009865
Contact Info: Paul Dabisch: paul.dabisch@nbacc.dhs.gov
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009865
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Battelle National Biodefense Institute; Gryphon Scientific LLC; Censeo Insight; Applied Research Associates
Keywords: SARS-CoV-2, inhalation, seroconversion, fever, dose response, primates
Summary of Study: SARS-CoV-2 infection and subsequent disease presentation are dependent on exposure dose in a nonhuman primate model of inhalational COVID-19.
References: PMID: 34424943 / doi: 10.1371/journal.ppat.1009865
Contact Info: Paul Dabisch: paul.dabisch@nbacc.dhs.gov
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009865
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: VaxiGen, Inc., Genexine, Inc., Korea National Primate Research Centre, and others
Keywords: SARS-CoV-2, DNA-based vaccine, mice and primates, immune response
Summary of Study: A synthetic soluble SARS-CoV-2 spike (S) DNA-based vaccine candidate, GX-19, provides a durable protective immune response in rhesus macaques, supporting further development of GX-19 as a vaccine candidate for SARS-CoV-2.
References: PMID: 33804981 / doi: 10.3390/vaccines9040307
Contact Info: Yong Bok Seo: ybseo@slvaxigen.com; You Suk Suh: yssuh@genexine.com; Jung Joo Hong: hong75@kribb.re.kr
URL: https://www.mdpi.com/2076-393X/9/4/307
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: VaxiGen, Inc., Genexine, Inc., Korea National Primate Research Centre, and others
Keywords: SARS-CoV-2, DNA-based vaccine, mice and primates, immune response
Summary of Study: A synthetic soluble SARS-CoV-2 spike (S) DNA-based vaccine candidate, GX-19, provides a durable protective immune response in rhesus macaques, supporting further development of GX-19 as a vaccine candidate for SARS-CoV-2.
References: PMID: 33804981 / doi: 10.3390/vaccines9040307
Contact Info: Yong Bok Seo: ybseo@slvaxigen.com; You Suk Suh: yssuh@genexine.com; Jung Joo Hong: hong75@kribb.re.kr
URL: https://www.mdpi.com/2076-393X/9/4/307
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Univ. of Pennsylvania Perelman School of Medicine
Keywords: SARS-CoV-2, D614G Spike Mutation, Vaccinated and immune sera, neutralization, primates
Summary of Study: Vaccinated NHPs using the nucleoside-modified mRNA-LNP vaccine platform encoding four differentSARS-CoV-2 spike immunogens generate antibody responses that not only recognize the G614 mutation that has taken over the pandemic, but also have stronger titers of neutralization to this virus variant.
References: PMID: 33306985/doi: 10.1016/j.chom.2020.11.012
Contact Info: Drew Weissman (no contact information)
URL: https://www.sciencedirect.com/science/article/pii/S193131282030634X?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Univ. of Pennsylvania Perelman School of Medicine
Keywords: SARS-CoV-2, D614G Spike Mutation, Vaccinated and immune sera, neutralization, primates
Summary of Study: Vaccinated NHPs using the nucleoside-modified mRNA-LNP vaccine platform encoding four differentSARS-CoV-2 spike immunogens generate antibody responses that not only recognize the G614 mutation that has taken over the pandemic, but also have stronger titers of neutralization to this virus variant.
References: PMID: 33306985/doi: 10.1016/j.chom.2020.11.012
Contact Info: Drew Weissman (no contact information)
URL: https://www.sciencedirect.com/science/article/pii/S193131282030634X?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, inactivated vaccines, antibody-dependent enhancement, immunopathology, primates
Summary of Study: Results show that in the absence of cellular immunity, passive infusion of subneutralizing or nonneutralizing anti-SARS-CoV-2 antibodies could still provide some level of protection against infection upon challenge, and no low-level antibody-enhanced infection was observed.
References: PMID: 34736354 / doi: 10.1080/22221751.2021.2002670
Contact Info: Qihan Li: liqihan@imbcams.com.cn; Longding Liu: longdingliu@imbcams.com.cn; Cunbao Liu: cunbao_liu@163.com
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2002670
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, inactivated vaccines, antibody-dependent enhancement, immunopathology, primates
Summary of Study: Results show that in the absence of cellular immunity, passive infusion of subneutralizing or nonneutralizing anti-SARS-CoV-2 antibodies could still provide some level of protection against infection upon challenge, and no low-level antibody-enhanced infection was observed.
References: PMID: 34736354 / doi: 10.1080/22221751.2021.2002670
Contact Info: Qihan Li: liqihan@imbcams.com.cn; Longding Liu: longdingliu@imbcams.com.cn; Cunbao Liu: cunbao_liu@163.com
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2002670
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Nanogen Pharmaceutical Biotechnology Joint Stock Company; National Institute of Hygiene and Epidemiology (Hanoi, Vietnam)
Keywords: SARS-CoV-2, protein subunit vaccine, Nanocovax, pathogenesis, mice, hamsters, primates
Summary of Study: Nanocovax, a SARS-CoV-2 vaccine candidates based on recombinant protein production of the extracellular portion of the spike protein, was shown to be safe and effective in three animal models.
References: PMID: 34938290 / doi: 10.3389/fimmu.2021.766112
Contact Info: Min Si Do: minhsi@nanogenpharma.com
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.766112/full
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Nanogen Pharmaceutical Biotechnology Joint Stock Company; National Institute of Hygiene and Epidemiology (Hanoi, Vietnam)
Keywords: SARS-CoV-2, protein subunit vaccine, Nanocovax, pathogenesis, mice, hamsters, primates
Summary of Study: Nanocovax, a SARS-CoV-2 vaccine candidates based on recombinant protein production of the extracellular portion of the spike protein, was shown to be safe and effective in three animal models.
References: PMID: 34938290 / doi: 10.3389/fimmu.2021.766112
Contact Info: Min Si Do: minhsi@nanogenpharma.com
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.766112/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Yerkes National Primate Research Center, Emory University School of Medicine, Louisiana State University Health Science Center, Texas Children's Center for Vaccine Development, La Jolla Institute for Immunology, and others.
Keywords: SARS-CoV-2, vaccines and adjuvants, immune response, primates
Summary of Study: The adjuvant 3M-052-alum (previously shown to induce better immune responses against HIV) may be a way to improve the efficacy of SARS-CoV-2 vaccines.
References: PMID: 34266981 / doi: 10.1126/sciimmunol.abh3634
Contact Info: Sudhir Pai Kasturi: skastur@emory.edu; Maria Elena Bottazzi: bottazzi@bcm.edu
URL: https://www.science.org/doi/10.1126/sciimmunol.abh3634?url_ver=Z39.88-2003&rfr_…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Yerkes National Primate Research Center, Emory University School of Medicine, Louisiana State University Health Science Center, Texas Children's Center for Vaccine Development, La Jolla Institute for Immunology, and others.
Keywords: SARS-CoV-2, vaccines and adjuvants, immune response, primates
Summary of Study: The adjuvant 3M-052-alum (previously shown to induce better immune responses against HIV) may be a way to improve the efficacy of SARS-CoV-2 vaccines.
References: PMID: 34266981 / doi: 10.1126/sciimmunol.abh3634
Contact Info: Sudhir Pai Kasturi: skastur@emory.edu; Maria Elena Bottazzi: bottazzi@bcm.edu
URL: https://www.science.org/doi/10.1126/sciimmunol.abh3634?url_ver=Z39.88-2003&rfr_…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Wuhan Institute of Virology, Tongji Medical College, University of Chinese Academy of Sciences, Wuhan Institute of Biological Products Co.
Keywords: SARS-CoV-2, inactivated vaccine, mice and primates, immune response
Summary of Study: The authors tested the safety, immunogenicity and efficacy of an inactivated vaccine based on on the whole viral particles in human ACE2 transgenic mouse and in NHPs. This inactivated vaccine successfully induced SARS-CoV-2-specific neutralizing antibodies in both models.
References: PMID: 33835391 / doi: 10.1007/s12250-021-00376-w
Contact Info: Xing-Lou Yang: yangsx@wh.iov.cn; Shuo Shen: shenshuo1@sinopharm.com; Zhi-Ming Yuan: yzm@wh.iov.cn
URL: https://link.springer.com/article/10.1007%2Fs12250-021-00376-w
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Wuhan Institute of Virology, Tongji Medical College, University of Chinese Academy of Sciences, Wuhan Institute of Biological Products Co.
Keywords: SARS-CoV-2, inactivated vaccine, mice and primates, immune response
Summary of Study: The authors tested the safety, immunogenicity and efficacy of an inactivated vaccine based on on the whole viral particles in human ACE2 transgenic mouse and in NHPs. This inactivated vaccine successfully induced SARS-CoV-2-specific neutralizing antibodies in both models.
References: PMID: 33835391 / doi: 10.1007/s12250-021-00376-w
Contact Info: Xing-Lou Yang: yangsx@wh.iov.cn; Shuo Shen: shenshuo1@sinopharm.com; Zhi-Ming Yuan: yzm@wh.iov.cn
URL: https://link.springer.com/article/10.1007%2Fs12250-021-00376-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Xiamen University, The University of HongKong, Shantou University, Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, review of the primate models, clinical symptoms, pathogenesis, applications
Summary of Study: Review summarizes the benefits and caveats of NHP models currently available for SARS-CoV-2 and discusses key topics including model optimization, extended application, and clinical translation.
References: PMID: 34490832 / doi: 10.1080/22221751.2021.1976598
Contact Info: Tong Cheng: tcheng@xmu.edu.cn; Ningshao Xia: nsxia@xmu.edu.cn
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1976598
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Xiamen University, The University of HongKong, Shantou University, Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, review of the primate models, clinical symptoms, pathogenesis, applications
Summary of Study: Review summarizes the benefits and caveats of NHP models currently available for SARS-CoV-2 and discusses key topics including model optimization, extended application, and clinical translation.
References: PMID: 34490832 / doi: 10.1080/22221751.2021.1976598
Contact Info: Tong Cheng: tcheng@xmu.edu.cn; Ningshao Xia: nsxia@xmu.edu.cn
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1976598
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Kazan State Medical Academy; Kazan State Medical University; Kazan Federal University
Keywords: SARS-CoV-2, infection, pathogenicity, eye surface, literature meta analysis, primates
Summary of Study: There is a possibility of COVID-19 transmission through the eye surface. Eye protection measures should be undertaken when working with potentially infected patients.
References: PMID: 34410064 / doi: 10.17116/oftalma2021137041104
Contact Info: not provided
URL: https://pubmed.ncbi.nlm.nih.gov/34410064/
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Kazan State Medical Academy; Kazan State Medical University; Kazan Federal University
Keywords: SARS-CoV-2, infection, pathogenicity, eye surface, literature meta analysis, primates
Summary of Study: There is a possibility of COVID-19 transmission through the eye surface. Eye protection measures should be undertaken when working with potentially infected patients.
References: PMID: 34410064 / doi: 10.17116/oftalma2021137041104
Contact Info: not provided
URL: https://pubmed.ncbi.nlm.nih.gov/34410064/
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Melbourne, Monash University
Keywords: SARS-CoV-2, prime-boost protein subunit vaccine, mice and primates
Summary of Study: Both S and RBD vaccines are comparably immunogenic and produced strong serological neutralizing responses in pig-tailed macaques. Overall, immunization with recombinant S immunogens reliably elicits potentially protective humoral immunity at levels in excess of those observed in convalescent human, confirming recombinant S proteins as promising vaccine candidates.
References: PMID: 33658497 / doi: 10.1038/s41467-021-21665-8
Contact Info: Stephen Kent: skent@unimelb.edu.au
URL: https://www.nature.com/articles/s41467-021-21665-8
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Melbourne, Monash University
Keywords: SARS-CoV-2, prime-boost protein subunit vaccine, mice and primates
Summary of Study: Both S and RBD vaccines are comparably immunogenic and produced strong serological neutralizing responses in pig-tailed macaques. Overall, immunization with recombinant S immunogens reliably elicits potentially protective humoral immunity at levels in excess of those observed in convalescent human, confirming recombinant S proteins as promising vaccine candidates.
References: PMID: 33658497 / doi: 10.1038/s41467-021-21665-8
Contact Info: Stephen Kent: skent@unimelb.edu.au
URL: https://www.nature.com/articles/s41467-021-21665-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Chinese Academy of Sciences; State Key Laboratory of Pathogen an dBiosecutiry, Academy of Military Medical Sciences, Beijing; Sinocelltech Ltd., National Institutes for Food and Drug Control, Beijing; Institute for Biological Product Control, Beijing
Keywords: SARS-CoV-2, monoclonal antibody, preclinical safety evaluation, cryo-EM structure, mice, primates
Summary of Study: Increasing access to panels of authentic neutralizing monoclonal antibodies will facilitate structure-function studies to unpick the underlying biological processes of virus-host interactions, and provide molecular basis for applying HB27 for potential COVID-19 treatment.
References: PMID: 34676096 / doi: 10.1093/nsr/nwaa297
Contact Info: Cheng-Feng Qin: qincf@bmi.ac.cn; Xiangxi Wang: xiangxi@ibp.ac.cn; Youchun Wang: wangyc@nifdc.org.cn; Zihe Rao: raozh@tsinghua.edu.cn; Liangzhi Xie: liangzhi@yahoo.com
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798916/
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Chinese Academy of Sciences; State Key Laboratory of Pathogen an dBiosecutiry, Academy of Military Medical Sciences, Beijing; Sinocelltech Ltd., National Institutes for Food and Drug Control, Beijing; Institute for Biological Product Control, Beijing
Keywords: SARS-CoV-2, monoclonal antibody, preclinical safety evaluation, cryo-EM structure, mice, primates
Summary of Study: Increasing access to panels of authentic neutralizing monoclonal antibodies will facilitate structure-function studies to unpick the underlying biological processes of virus-host interactions, and provide molecular basis for applying HB27 for potential COVID-19 treatment.
References: PMID: 34676096 / doi: 10.1093/nsr/nwaa297
Contact Info: Cheng-Feng Qin: qincf@bmi.ac.cn; Xiangxi Wang: xiangxi@ibp.ac.cn; Youchun Wang: wangyc@nifdc.org.cn; Zihe Rao: raozh@tsinghua.edu.cn; Liangzhi Xie: liangzhi@yahoo.com
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798916/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: California National Primate Research Center; University of California, Davis; Louisiana State University Health Sciences Center; The Rockefeller University.
Keywords: SARS-CoV-2, neuroinflammation, effector CD4 T cells, inflammation, cerebrospinal fluid, pneumonia, primates
Summary of Study: Neutralizing mABs administered preventatively to high-risk populations may mitigate the adverse inflammatory consequences of SARS-CoV-2 exposure.
References: PMID: 34706272 / doi: 10.1016/j.celrep.2021.109942
Contact Info: Smita Iyer: smiyer@ucdavis.edu
URL: https://www.sciencedirect.com/science/article/pii/S2211124721014157?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: California National Primate Research Center; University of California, Davis; Louisiana State University Health Sciences Center; The Rockefeller University.
Keywords: SARS-CoV-2, neuroinflammation, effector CD4 T cells, inflammation, cerebrospinal fluid, pneumonia, primates
Summary of Study: Neutralizing mABs administered preventatively to high-risk populations may mitigate the adverse inflammatory consequences of SARS-CoV-2 exposure.
References: PMID: 34706272 / doi: 10.1016/j.celrep.2021.109942
Contact Info: Smita Iyer: smiyer@ucdavis.edu
URL: https://www.sciencedirect.com/science/article/pii/S2211124721014157?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Wuhan Institute of Virology, Chinese Academy of Sciences; University of the Chinese Academy of Sciences; Wuhan YZY Biopharma Co., Ltd.
Keywords: SARS-CoV-2, subunit vaccine, immunity, virus load, pathology, primates
Summary of Study: The RBD-homodimer vaccine candidate studied can induce both humoral and cellular response in vivo and prevent SARS-CoV-2 infection in both rodents and non-human primates. Production of this RBD vaccine candidate can be performed in large scale, which will enhance the vaccine supply and warrants future clinical trials.
References: PMID: 34493710 / doi: 10.1038/s41421-021-00320-y
Contact Info: Zhiming Yuan: yzm@wh.iov.cn; Chao Shan: shanchao@wh.iov.cn; Genfu Xiao: xiaogf@wh.iov.cn
URL: https://www.nature.com/articles/s41421-021-00320-y
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Wuhan Institute of Virology, Chinese Academy of Sciences; University of the Chinese Academy of Sciences; Wuhan YZY Biopharma Co., Ltd.
Keywords: SARS-CoV-2, subunit vaccine, immunity, virus load, pathology, primates
Summary of Study: The RBD-homodimer vaccine candidate studied can induce both humoral and cellular response in vivo and prevent SARS-CoV-2 infection in both rodents and non-human primates. Production of this RBD vaccine candidate can be performed in large scale, which will enhance the vaccine supply and warrants future clinical trials.
References: PMID: 34493710 / doi: 10.1038/s41421-021-00320-y
Contact Info: Zhiming Yuan: yzm@wh.iov.cn; Chao Shan: shanchao@wh.iov.cn; Genfu Xiao: xiaogf@wh.iov.cn
URL: https://www.nature.com/articles/s41421-021-00320-y
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Korea Research Institute of Bioscience & Biotechnology, Chonnam National University, Chungbuk National University
Keywords: SARS-CoV-2, virus variants, microevolution, species specific variations, primates
Summary of Study: The genomes of SARS-CoV-2 differ according to individuals and species despite infection of the identical virus in NHPs. These results are important for the interprretation of longitudinal studies evaluating the evolution of the SARS-CoV-2 in humans and development of new diagnostics, vaccine, and therapeutics targeting SARS-CoV-2.
References: PMID: 34305860 / doi: 10.3389/fmicb.2021.694897
Contact Info: Jungjoo Hong: hong75@kribb.re.kr; Bon-Sang Koo: porco9@kribb.re.kr
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2021.694897/full
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Korea Research Institute of Bioscience & Biotechnology, Chonnam National University, Chungbuk National University
Keywords: SARS-CoV-2, virus variants, microevolution, species specific variations, primates
Summary of Study: The genomes of SARS-CoV-2 differ according to individuals and species despite infection of the identical virus in NHPs. These results are important for the interprretation of longitudinal studies evaluating the evolution of the SARS-CoV-2 in humans and development of new diagnostics, vaccine, and therapeutics targeting SARS-CoV-2.
References: PMID: 34305860 / doi: 10.3389/fmicb.2021.694897
Contact Info: Jungjoo Hong: hong75@kribb.re.kr; Bon-Sang Koo: porco9@kribb.re.kr
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2021.694897/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Laboratory of Virology, Hamilton, MT; NIAID; University of Plymouth, Plymouth, UK; The Vaccine Group, Ltd.
Keywords: SARS-CoV-2, virus genomic variants, pathology, virus replication, shedding, primates
Summary of Study: Results from the intranasal AGM COVID-19 surrogate model support the most recent data from B.1.1.7 in humans, providing direct empirical data for increased replication in the respiratory tissue, but with no enhancement of disease.
References: PMID: 34724885 / doi: 10.1080/22221751.2021.1997074
Contact Info: Heinz Feldmann: feldmannh@niaid.nih.gov
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1997074
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Laboratory of Virology, Hamilton, MT; NIAID; University of Plymouth, Plymouth, UK; The Vaccine Group, Ltd.
Keywords: SARS-CoV-2, virus genomic variants, pathology, virus replication, shedding, primates
Summary of Study: Results from the intranasal AGM COVID-19 surrogate model support the most recent data from B.1.1.7 in humans, providing direct empirical data for increased replication in the respiratory tissue, but with no enhancement of disease.
References: PMID: 34724885 / doi: 10.1080/22221751.2021.1997074
Contact Info: Heinz Feldmann: feldmannh@niaid.nih.gov
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1997074
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Amsterdam, Universite Paris-Saclay, University of Southampton, and others
Keywords: SARS-CoV-2, two-component protein nanoparticle vaccine, primates
Summary of Study: A two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein induces potent neutralizing antibody responses in cynomolgus macaques. The vaccine-induced immunity protects macaques against a high-dose challenge, resulting in strongly reduced viral infection and replication in the upper and lower airways. These nanoparticles are a promising vaccine candidate.
References: PMID: 33577765 / doi: 10.1016/j.cell.2021.01.035
Contact Info: Roger Le Grand: roger.le-grand@cea.fr; Rogier Sanders: r.w.sanders@amsterdamumc.nl
URL: https://www.sciencedirect.com/science/article/pii/S0092867421000787?via%3Dihub=
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Amsterdam, Universite Paris-Saclay, University of Southampton, and others
Keywords: SARS-CoV-2, two-component protein nanoparticle vaccine, primates
Summary of Study: A two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein induces potent neutralizing antibody responses in cynomolgus macaques. The vaccine-induced immunity protects macaques against a high-dose challenge, resulting in strongly reduced viral infection and replication in the upper and lower airways. These nanoparticles are a promising vaccine candidate.
References: PMID: 33577765 / doi: 10.1016/j.cell.2021.01.035
Contact Info: Roger Le Grand: roger.le-grand@cea.fr; Rogier Sanders: r.w.sanders@amsterdamumc.nl
URL: https://www.sciencedirect.com/science/article/pii/S0092867421000787?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Institute of Human Virology, Zhongshan School of Medicine
Keywords: SARS-CoV-2, convalescent sera, receptor-binding domain based nanoparticles, virus variants, primates
Summary of Study: Results show that as mutations accumulate in the RBD, spike proteins may acquire an antigenic shift that enable SARS-CoV-2 variants to eventually resist the current vaccines. Intensive monitoring of virus mutations and timely adjustment of the designed vaccines are required to control the viral pandemic.
References: PMID: 33580167 / doi: 10.1038/s41423-021-00641-8
Contact Info: Xin He: hexin59@mail.sysu.edu.cn
URL: https://www.nature.com/articles/s41423-021-00641-8
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Institute of Human Virology, Zhongshan School of Medicine
Keywords: SARS-CoV-2, convalescent sera, receptor-binding domain based nanoparticles, virus variants, primates
Summary of Study: Results show that as mutations accumulate in the RBD, spike proteins may acquire an antigenic shift that enable SARS-CoV-2 variants to eventually resist the current vaccines. Intensive monitoring of virus mutations and timely adjustment of the designed vaccines are required to control the viral pandemic.
References: PMID: 33580167 / doi: 10.1038/s41423-021-00641-8
Contact Info: Xin He: hexin59@mail.sysu.edu.cn
URL: https://www.nature.com/articles/s41423-021-00641-8