Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Nanogen Pharmaceutical Biotechnology Joint Stock Company; National Institute of Hygiene and Epidemiology (Hanoi, Vietnam)
Keywords: SARS-CoV-2, protein subunit vaccine, Nanocovax, pathogenesis, mice, hamsters, primates
Summary of Study: Nanocovax, a SARS-CoV-2 vaccine candidates based on recombinant protein production of the extracellular portion of the spike protein, was shown to be safe and effective in three animal models.
References: PMID: 34938290 / doi: 10.3389/fimmu.2021.766112
Contact Info: Min Si Do: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.766112/full
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Nanogen Pharmaceutical Biotechnology Joint Stock Company; National Institute of Hygiene and Epidemiology (Hanoi, Vietnam)
Keywords: SARS-CoV-2, protein subunit vaccine, Nanocovax, pathogenesis, mice, hamsters, primates
Summary of Study: Nanocovax, a SARS-CoV-2 vaccine candidates based on recombinant protein production of the extracellular portion of the spike protein, was shown to be safe and effective in three animal models.
References: PMID: 34938290 / doi: 10.3389/fimmu.2021.766112
Contact Info: Min Si Do: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.766112/full
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Amsterdam; INSERM, CEA; National Institute for Public Health and the Environment, RIVM; Public Health Service of Amsterdam; Tergooi Hospital; Amsterdam Neuroscience, AMC; Amsterdam Infection & Immunity, AMC; Amsterdam Infection & Immunity, VUmc; The University of Melbourne; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, cross-reactive antibodies, human coronaviruses, primates
Summary of Study: The results from this study on the presence and specificity of cross-reactive antibodies to other hCoVs after SARS-CoV-2 infection and vaccination emphasize the feasibility of broad coronavirus vaccines and may guide future vaccine designs.
References: PMID: 34812143 / doi: 10.7554/eLife.70330
Contact Info: Marit J van Gils: [email protected]
URL: https://elifesciences.org/articles/70330
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Amsterdam; INSERM, CEA; National Institute for Public Health and the Environment, RIVM; Public Health Service of Amsterdam; Tergooi Hospital; Amsterdam Neuroscience, AMC; Amsterdam Infection & Immunity, AMC; Amsterdam Infection & Immunity, VUmc; The University of Melbourne; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, cross-reactive antibodies, human coronaviruses, primates
Summary of Study: The results from this study on the presence and specificity of cross-reactive antibodies to other hCoVs after SARS-CoV-2 infection and vaccination emphasize the feasibility of broad coronavirus vaccines and may guide future vaccine designs.
References: PMID: 34812143 / doi: 10.7554/eLife.70330
Contact Info: Marit J van Gils: [email protected]
URL: https://elifesciences.org/articles/70330
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences, National Institute of Food and Drug Control (Beijing, China), Yunnan Provincial Infectious Disease Hospital, Yunnan Center for Disease Control and Prevention, Kunming Third People's Hospital
Keywords: SARS-CoV-2, inactivated virus vaccine, immune response, pathology, mice, primates
Summary of Study: Inactivated SARS-CoV-2 vaccine, produced by sequential inactivation with formaldehyde followed by propiolactone, was shown to be effective against SARS-Co-V 2 challenge in rhesus macaques.
References: PMID: 34462721 / doi: 10.1016/j.omtm.2021.08.005
Contact Info: Changgui Li: [email protected]; Qihan Li: [email protected]; Longding Liu: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2329050121001315?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences, National Institute of Food and Drug Control (Beijing, China), Yunnan Provincial Infectious Disease Hospital, Yunnan Center for Disease Control and Prevention, Kunming Third People's Hospital
Keywords: SARS-CoV-2, inactivated virus vaccine, immune response, pathology, mice, primates
Summary of Study: Inactivated SARS-CoV-2 vaccine, produced by sequential inactivation with formaldehyde followed by propiolactone, was shown to be effective against SARS-Co-V 2 challenge in rhesus macaques.
References: PMID: 34462721 / doi: 10.1016/j.omtm.2021.08.005
Contact Info: Changgui Li: [email protected]; Qihan Li: [email protected]; Longding Liu: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2329050121001315?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Tehran, Tabriz University of Medical Sciences, Karolinska Institute, University of Rochester Medical Center, Tokyo University of Science, University of Veterinary Medicine (Vienna)
Keywords: SARS-CoV-2, immune response, reinfection, recovery, primates
Summary of Study: Review paper proposing a new strategy to predict the potential of reinfection in each identified category. This classification may help to distribute resources more meticulously to determine: Who needs to be serologically tested for SARS-CoV-2 neutralizing antibodies, what percentage of the population is immune to the virus, and who needs to be vaccinated.
References: PMID: 33520309 / doi: 10.1016/jare.2020.12.013
Contact Info: Younes Aftabi: [email protected]; Sasan Fereidouni: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2090123220302630?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Tehran, Tabriz University of Medical Sciences, Karolinska Institute, University of Rochester Medical Center, Tokyo University of Science, University of Veterinary Medicine (Vienna)
Keywords: SARS-CoV-2, immune response, reinfection, recovery, primates
Summary of Study: Review paper proposing a new strategy to predict the potential of reinfection in each identified category. This classification may help to distribute resources more meticulously to determine: Who needs to be serologically tested for SARS-CoV-2 neutralizing antibodies, what percentage of the population is immune to the virus, and who needs to be vaccinated.
References: PMID: 33520309 / doi: 10.1016/jare.2020.12.013
Contact Info: Younes Aftabi: [email protected]; Sasan Fereidouni: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2090123220302630?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Shanghai Jemincare Pharmaceuticals Co.; Chinese Academy of Sciences; Tongji Medical College of Huazhong University of Science & Technology
Keywords: SARS-CoV-2, neutralizing antibodies, immune response, primates
Summary of Study: Two potent nABs against SARS-CoV-2 from naive phage-displayed human B cell single-chain variable fragment libraries were identified. One, JMB2002) not only showed potent in vitro blocking activity against a broad-spectrum of SARS-CoV-2 variants including the B.1.351 lineage, but also potent therapeutic efficacy and complete prophylactic protection against SARS-CoV-2 in a rhesus macaque infection model. Prophylactic and therapeutic countermeasure intervention of SARS-CoV-2 using antibody JMB2002 would likely slow down the transmission of currently emerged SARS-CoV-2 variants and result in more efficient control of the COVID-19 pandemic.
References: PMID: 34097570 / doi: 10.1080/19420862.2021.1930636
Contact Info: Su-Jun Deng: [email protected]; Wuxiang Guan: [email protected]; Zhiming Yuan: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/19420862.2021.1930636
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Shanghai Jemincare Pharmaceuticals Co.; Chinese Academy of Sciences; Tongji Medical College of Huazhong University of Science & Technology
Keywords: SARS-CoV-2, neutralizing antibodies, immune response, primates
Summary of Study: Two potent nABs against SARS-CoV-2 from naive phage-displayed human B cell single-chain variable fragment libraries were identified. One, JMB2002) not only showed potent in vitro blocking activity against a broad-spectrum of SARS-CoV-2 variants including the B.1.351 lineage, but also potent therapeutic efficacy and complete prophylactic protection against SARS-CoV-2 in a rhesus macaque infection model. Prophylactic and therapeutic countermeasure intervention of SARS-CoV-2 using antibody JMB2002 would likely slow down the transmission of currently emerged SARS-CoV-2 variants and result in more efficient control of the COVID-19 pandemic.
References: PMID: 34097570 / doi: 10.1080/19420862.2021.1930636
Contact Info: Su-Jun Deng: [email protected]; Wuxiang Guan: [email protected]; Zhiming Yuan: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/19420862.2021.1930636
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NCI, Frederick National Laboratory for Cancer Research, BIOQUAL, University of Athens School of Medicine, University of Washington
Keywords: SARS-CoV-2, DNA-based vaccine, immune response, primates
Summary of Study: A vaccine regimen comprising simultaneous co-immunization of DNA and Protein at the same anatomical site showed best neutralizing abilities and was more effective than DNA alone in inducing protective immune responses and controlling SARS-CoV-2 infection. An expansion of the DNA vaccine regimen to include co-immunization with Spike protein may be of advantage for SARS-CoV-2.
References: PMID: 34551020 / doi: 10.1371/journal.ppat.1009701
Contact Info: Barbara Felber: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009701
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NCI, Frederick National Laboratory for Cancer Research, BIOQUAL, University of Athens School of Medicine, University of Washington
Keywords: SARS-CoV-2, DNA-based vaccine, immune response, primates
Summary of Study: A vaccine regimen comprising simultaneous co-immunization of DNA and Protein at the same anatomical site showed best neutralizing abilities and was more effective than DNA alone in inducing protective immune responses and controlling SARS-CoV-2 infection. An expansion of the DNA vaccine regimen to include co-immunization with Spike protein may be of advantage for SARS-CoV-2.
References: PMID: 34551020 / doi: 10.1371/journal.ppat.1009701
Contact Info: Barbara Felber: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009701
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: King Mongkut's University of Technology; Chulalongkorn University; Mahidol University; B.F. Feed Company, Ltd.
Keywords: SARS-CoV-2, spike receptor-binding domain, immunization, convalescent sera, B-cell epitopes, primates
Summary of Study: The immunoinformatics method described could be a useful tool for identification of antibody epitopes in new virus variants and also other target proteins.
References: PMID: 34650130 / doi: 10.1038/s41598-021-99642-w
Contact Info: Yaowaluck Mapring Roshorm: [email protected]
URL: https://www.nature.com/articles/s41598-021-99642-w
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: King Mongkut's University of Technology; Chulalongkorn University; Mahidol University; B.F. Feed Company, Ltd.
Keywords: SARS-CoV-2, spike receptor-binding domain, immunization, convalescent sera, B-cell epitopes, primates
Summary of Study: The immunoinformatics method described could be a useful tool for identification of antibody epitopes in new virus variants and also other target proteins.
References: PMID: 34650130 / doi: 10.1038/s41598-021-99642-w
Contact Info: Yaowaluck Mapring Roshorm: [email protected]
URL: https://www.nature.com/articles/s41598-021-99642-w
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: National Institute of Infectious Diseases, Japan; University of Tokyo; Kumamoto University, and others
Keywords: SARS-CoV-2, virus-specific CD8+ T-cell responses, virus replication, immune response, primates
Summary of Study: The effect of CD8+ cell depletion on SARS-CoV-2 replication when monoclonal anti-CD8 antibody is administered in the subacute phase was studied in cynomolgus macaques. Analysis revealed no significant impact of CD8+ cell depletion on viral replication, indicating the subacute SARS-CoV-2 replication can be controlled in the absence of CD8+ T cells.
References: PMID: 34280241 / doi: 10.1371/journal.ppat.1009668
Contact Info: Tetsuro Matano: [email protected]; Takushi Nomura: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009668
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: National Institute of Infectious Diseases, Japan; University of Tokyo; Kumamoto University, and others
Keywords: SARS-CoV-2, virus-specific CD8+ T-cell responses, virus replication, immune response, primates
Summary of Study: The effect of CD8+ cell depletion on SARS-CoV-2 replication when monoclonal anti-CD8 antibody is administered in the subacute phase was studied in cynomolgus macaques. Analysis revealed no significant impact of CD8+ cell depletion on viral replication, indicating the subacute SARS-CoV-2 replication can be controlled in the absence of CD8+ T cells.
References: PMID: 34280241 / doi: 10.1371/journal.ppat.1009668
Contact Info: Tetsuro Matano: [email protected]; Takushi Nomura: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009668
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences; Peking Union Medical College; Capital Medical University
Keywords: SARS-CoV-2, pathology, myocardial injury, differential expression, primates
Summary of Study: SARS-CoV-2 infected rhesus macaques showed viral myocarditis, where inflammation and endothelial injury jointly resulted in cardiac damage.
References: PMID: 34489396 / doi: 10.1038/s413392-021-00747-5
Contact Info: Jiangning Liu: [email protected]; Jing Wang: [email protected]
URL: https://www.nature.com/articles/s41392-021-00747-5
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences; Peking Union Medical College; Capital Medical University
Keywords: SARS-CoV-2, pathology, myocardial injury, differential expression, primates
Summary of Study: SARS-CoV-2 infected rhesus macaques showed viral myocarditis, where inflammation and endothelial injury jointly resulted in cardiac damage.
References: PMID: 34489396 / doi: 10.1038/s413392-021-00747-5
Contact Info: Jiangning Liu: [email protected]; Jing Wang: [email protected]
URL: https://www.nature.com/articles/s41392-021-00747-5
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Harvard Univ., MIT, Tulane National Primate Research Center
Keywords: SARS-CoV-2, respiratory droplet generation and exhalation, primates
Summary of Study: The proportion of small respiratory droplets (the majority of particles exhaled in all subjects) increased at the peak of COVID-19 infection in NHPs. This confirms a previously published observation from the exhaled aerosol profile of a single COVID-19 positive human subject, and suggests that, at peak infection, there may be an elevated risk of the airborne transmission of SARS-CoV-2 by way of the very small droplets that transmit through conventional masks and travers distances far exceeding the conventional social distance of 2 m.
References: PMID: 33563754 / doi: 10.1073/pnas.2021830118
Contact Info: David Edwards: [email protected]; Chad Roy: [email protected]
URL: https://www.pnas.org/content/118/8/e2021830118.long
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Harvard Univ., MIT, Tulane National Primate Research Center
Keywords: SARS-CoV-2, respiratory droplet generation and exhalation, primates
Summary of Study: The proportion of small respiratory droplets (the majority of particles exhaled in all subjects) increased at the peak of COVID-19 infection in NHPs. This confirms a previously published observation from the exhaled aerosol profile of a single COVID-19 positive human subject, and suggests that, at peak infection, there may be an elevated risk of the airborne transmission of SARS-CoV-2 by way of the very small droplets that transmit through conventional masks and travers distances far exceeding the conventional social distance of 2 m.
References: PMID: 33563754 / doi: 10.1073/pnas.2021830118
Contact Info: David Edwards: [email protected]; Chad Roy: [email protected]
URL: https://www.pnas.org/content/118/8/e2021830118.long
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Karolinska Institutet; University of Cape Town
Keywords: SARS-CoV-2, virus genomic variants, antigenic sin, boost, passive immunization, mice, primates
Summary of Study: A single dose of adjuvanted beta variant receptor binding domain (RBD) protein broadens neutralizing antibody responses to heterologous VOCs.
References: PMID: 34723224 / doi: 10.1016/j.xcrm.2021.100450
Contact Info: Daniel Sheward: [email protected]; Gunilla Karlsson Hedestam: [email protected]; Ben Murrell: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379121003189?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Karolinska Institutet; University of Cape Town
Keywords: SARS-CoV-2, virus genomic variants, antigenic sin, boost, passive immunization, mice, primates
Summary of Study: A single dose of adjuvanted beta variant receptor binding domain (RBD) protein broadens neutralizing antibody responses to heterologous VOCs.
References: PMID: 34723224 / doi: 10.1016/j.xcrm.2021.100450
Contact Info: Daniel Sheward: [email protected]; Gunilla Karlsson Hedestam: [email protected]; Ben Murrell: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379121003189?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Copycat Sciences; Sporos Bioventures
Keywords: SARS-CoV-2, redelivery, analysis of the preclinical data and clinical efficacy, primates
Summary of Study: The gap between the strong preclinical data with remdesivir (RDV) across many virus models and its questionable clinical activity suggests that assumptions are being made at the preclinical level that do not reflect the conditions observed in patients.
References: PMID: 34252308 / doi: 10.1128/AAC.01117-21
Contact Info: Victoria Yan: [email protected]
URL: https://journals.asm.org/doi/10.1128/AAC.01117-21?url_ver=Z39.88-2003&rfr_id=or…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Copycat Sciences; Sporos Bioventures
Keywords: SARS-CoV-2, redelivery, analysis of the preclinical data and clinical efficacy, primates
Summary of Study: The gap between the strong preclinical data with remdesivir (RDV) across many virus models and its questionable clinical activity suggests that assumptions are being made at the preclinical level that do not reflect the conditions observed in patients.
References: PMID: 34252308 / doi: 10.1128/AAC.01117-21
Contact Info: Victoria Yan: [email protected]
URL: https://journals.asm.org/doi/10.1128/AAC.01117-21?url_ver=Z39.88-2003&rfr_id=or…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: USC, , UCLA, City of Hope, Bioqual
Keywords: SARS-CoV-2, pancreatic beta cells, toxicity, metabolism, primates
Summary of Study: SARS-CoV-2 infection enhances beta cell stress that may compromise beta-cell function beyond the duration of the disease course, raising the possibility that the beta cell stress and injury may have clinical implications to the long-term future health of patients that have recovered from COVID19.
References: PMID: 34312617 / doi: 10.21203/rs.3.rs-592374/v1
Contact Info: Senta Georgia: [email protected]
URL: https://www.researchsquare.com/article/rs-592374/v1
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: USC, , UCLA, City of Hope, Bioqual
Keywords: SARS-CoV-2, pancreatic beta cells, toxicity, metabolism, primates
Summary of Study: SARS-CoV-2 infection enhances beta cell stress that may compromise beta-cell function beyond the duration of the disease course, raising the possibility that the beta cell stress and injury may have clinical implications to the long-term future health of patients that have recovered from COVID19.
References: PMID: 34312617 / doi: 10.21203/rs.3.rs-592374/v1
Contact Info: Senta Georgia: [email protected]
URL: https://www.researchsquare.com/article/rs-592374/v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Universite Paris-Saclay, Inserm; Pereman School of Medicine; Novartis Gene Therapies; Boston University School of Medicine; Institute Pasteur; Mass General Brigham Innovation; Albamunity
Keywords: SARS-CoV-2, AAV-based vaccine, immunogenicity, thermostability, mice, primates
Summary of Study: AAVrh32.33 technology demonstrated its utility as a preventative vaccine for COVID19, and its unique attributes may be applicable to other pathogens or immunization targets.
References: PMID: 34428428 / doi: 10.1016/j.chom.2021.08.002
Contact Info: Luk Vandenberghe: [email protected]; Roger Le Grand: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1931312821003784?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Universite Paris-Saclay, Inserm; Pereman School of Medicine; Novartis Gene Therapies; Boston University School of Medicine; Institute Pasteur; Mass General Brigham Innovation; Albamunity
Keywords: SARS-CoV-2, AAV-based vaccine, immunogenicity, thermostability, mice, primates
Summary of Study: AAVrh32.33 technology demonstrated its utility as a preventative vaccine for COVID19, and its unique attributes may be applicable to other pathogens or immunization targets.
References: PMID: 34428428 / doi: 10.1016/j.chom.2021.08.002
Contact Info: Luk Vandenberghe: [email protected]; Roger Le Grand: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1931312821003784?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: SW National Primate Research Center, Washington University School of Medicine, Texas Biomedical Research Institute, Tulane University
Keywords: SARS-CoV-2, single-cell RNA sequencing. Immune response, primates
Summary of Study: The recruitment of a myeloid-cell-mediated Type I IFN response is associated with the rapid clearance of SARS-CoV-2 infection in macaques.
References: PMID: 34282414 / doi: 10.21203/rs.3.rs-664507/v1
Contact Info: Deepak Kaushal: [email protected]
URL: https://www.researchsquare.com/article/rs-664507/v1
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: SW National Primate Research Center, Washington University School of Medicine, Texas Biomedical Research Institute, Tulane University
Keywords: SARS-CoV-2, single-cell RNA sequencing. Immune response, primates
Summary of Study: The recruitment of a myeloid-cell-mediated Type I IFN response is associated with the rapid clearance of SARS-CoV-2 infection in macaques.
References: PMID: 34282414 / doi: 10.21203/rs.3.rs-664507/v1
Contact Info: Deepak Kaushal: [email protected]
URL: https://www.researchsquare.com/article/rs-664507/v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Public Health England; University of Oxford; Oxford University Hospitals NHS Foundation Trust; Quadram Institute Bioscience
Keywords: SARS-CoV-2, inactivated vaccine, vaccine-enhanced disease, pathology, ferrets, primates
Summary of Study: Studies assessed the potential for VED (vaccine-enhanced disease) in animals vaccinated with formaldehyde-inactivated SARS-CoV-2 formulated with Alhydrogel, compared to a negative control vaccine. No evidence of enhanced disease was shown in ferrets of rhesus macaques except for mild transient enhanced disease seen 7 days after infection in ferrets. This was resolved by day 15.
References: PMID: 34516768 / doi: 10.1126/sciadv.abg7996
Contact Info: Miles Carol: [email protected]; Andrew Gorringe: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.abg7996?url_ver=Z39.88-2003&rfr_id=o…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Public Health England; University of Oxford; Oxford University Hospitals NHS Foundation Trust; Quadram Institute Bioscience
Keywords: SARS-CoV-2, inactivated vaccine, vaccine-enhanced disease, pathology, ferrets, primates
Summary of Study: Studies assessed the potential for VED (vaccine-enhanced disease) in animals vaccinated with formaldehyde-inactivated SARS-CoV-2 formulated with Alhydrogel, compared to a negative control vaccine. No evidence of enhanced disease was shown in ferrets of rhesus macaques except for mild transient enhanced disease seen 7 days after infection in ferrets. This was resolved by day 15.
References: PMID: 34516768 / doi: 10.1126/sciadv.abg7996
Contact Info: Miles Carol: [email protected]; Andrew Gorringe: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.abg7996?url_ver=Z39.88-2003&rfr_id=o…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre (BPRC, Netherlands), Utrecht University
Keywords: SARS-CoV-2, computed tomography, bronchoalveolar lavage, test interference, primates
Summary of Study: Thorax CTs were evaluated for alterations in lung density in health and experimentally SARS-CoV-infected female rhesus macaques before and after bronchoalveolar lavage (BAL). An increase in the lung density was observed on the post-BAL CT but resolved within 24 hours in the healthy animals; a significant difference in both the lung density and CT score was still found 24 hours post BAL in the infected animals.
References: PMID: 34242213 / doi: 10.1371/journal.pone.0252941
Contact Info: Marieke Stammes: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0252941
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre (BPRC, Netherlands), Utrecht University
Keywords: SARS-CoV-2, computed tomography, bronchoalveolar lavage, test interference, primates
Summary of Study: Thorax CTs were evaluated for alterations in lung density in health and experimentally SARS-CoV-infected female rhesus macaques before and after bronchoalveolar lavage (BAL). An increase in the lung density was observed on the post-BAL CT but resolved within 24 hours in the healthy animals; a significant difference in both the lung density and CT score was still found 24 hours post BAL in the infected animals.
References: PMID: 34242213 / doi: 10.1371/journal.pone.0252941
Contact Info: Marieke Stammes: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0252941
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, ACE2 expression, transcription factor AhR, pathology, primates
Summary of Study: Data in this study show that the transcription factor AhR is able to bind the promoter of the ACE2 gene, thus promoting ACE2 expression and augmenting the subsequent pathology in SARS-CoV-2-infected lungs.
References: PMID: 33795851 / doi: 10.1038/s41423-021-00672-1
Contact Info: Chuan Qin: [email protected]; Bo Huang: [email protected]
URL: https://www.nature.com/articles/s41423-021-00672-1
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, ACE2 expression, transcription factor AhR, pathology, primates
Summary of Study: Data in this study show that the transcription factor AhR is able to bind the promoter of the ACE2 gene, thus promoting ACE2 expression and augmenting the subsequent pathology in SARS-CoV-2-infected lungs.
References: PMID: 33795851 / doi: 10.1038/s41423-021-00672-1
Contact Info: Chuan Qin: [email protected]; Bo Huang: [email protected]
URL: https://www.nature.com/articles/s41423-021-00672-1
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Yale School of Medicine, Johns Hopkins School of Medicine
Keywords: SARS-CoV-2, ACE2, several animal species, immune response, pathology, primates
Summary of Study: This review summarized key clinical, radiologic, and pathologic features of human COVID-19, followed by a comparison with spontaneous and genetically altered animal models of SARS-CoV-2 infection.
References: PMID: 33836527 / doi: 10.1093/ilar/ilab0071
Contact Info: Caroline Zeiss: [email protected]
URL: https://academic.oup.com/ilarjournal/advance-article/doi/10.1093/ilar/ilab007/6…
NHP Species: african green monkeys, rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Yale School of Medicine, Johns Hopkins School of Medicine
Keywords: SARS-CoV-2, ACE2, several animal species, immune response, pathology, primates
Summary of Study: This review summarized key clinical, radiologic, and pathologic features of human COVID-19, followed by a comparison with spontaneous and genetically altered animal models of SARS-CoV-2 infection.
References: PMID: 33836527 / doi: 10.1093/ilar/ilab0071
Contact Info: Caroline Zeiss: [email protected]
URL: https://academic.oup.com/ilarjournal/advance-article/doi/10.1093/ilar/ilab007/6…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: The Wistar Institute; Inovio Pharmaceuticals; Bioqual
Keywords: SARS-CoV-2, DNA vaccine, immunogenicity, immune response, adaptive immune response, primates
Summary of Study: INO-4800, an intradermal-delivered SARS-CoV-2 spike DNA vaccine, induced both humoral and cellular arms of the adaptive immune system.
References: PMID: 34604818 / doi: 10.1016/j.xcrm.2021.100420
Contact Info: Kate Broderick: [email protected]; David Weiner: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379121002822?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: The Wistar Institute; Inovio Pharmaceuticals; Bioqual
Keywords: SARS-CoV-2, DNA vaccine, immunogenicity, immune response, adaptive immune response, primates
Summary of Study: INO-4800, an intradermal-delivered SARS-CoV-2 spike DNA vaccine, induced both humoral and cellular arms of the adaptive immune system.
References: PMID: 34604818 / doi: 10.1016/j.xcrm.2021.100420
Contact Info: Kate Broderick: [email protected]; David Weiner: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379121002822?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Shiga University of Medical Science, Otsu, Japan
Keywords: SARS-CoV-2, severe acute respiratory syndrome, immune response, primates
Summary of Study: Cynomolgus macaques infected with SARS-CoV-2 showed body temperature rises and X-ray radiographic pneumonia without life-threatening clinical signs of disease. Because of similar symptoms to approximately 80% of patients, cynomolgus macaques are appropriate to extrapolate the efficacy of vaccines and antiviral drugs for humans.
References: PMID: 33412411/doi: 10.1016/j.virol.2020.12.013
Contact Info: Yasushi Itoh (no contact information)
URL: https://www.sciencedirect.com/science/article/pii/S0042682220302609?via%3Dihub
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Shiga University of Medical Science, Otsu, Japan
Keywords: SARS-CoV-2, severe acute respiratory syndrome, immune response, primates
Summary of Study: Cynomolgus macaques infected with SARS-CoV-2 showed body temperature rises and X-ray radiographic pneumonia without life-threatening clinical signs of disease. Because of similar symptoms to approximately 80% of patients, cynomolgus macaques are appropriate to extrapolate the efficacy of vaccines and antiviral drugs for humans.
References: PMID: 33412411/doi: 10.1016/j.virol.2020.12.013
Contact Info: Yasushi Itoh (no contact information)
URL: https://www.sciencedirect.com/science/article/pii/S0042682220302609?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane NPRC, North Carolina State University
Keywords: SARS-CoV-2, portable, ultrasensitive saliva-based virus assay, primates
Summary of Study: CRISPR-FDS determined that mean SARS-Cov-2 RNA levels were 3.6 fold to 124-fold higher, and more stable, in oropharyngeal versus nasal swab samples from nonhuman primates at all time points after infection, suggesting that saliva may represent a more robust diagnostic sample than nasal swabs both early and later in infection.
References: PMID: 33310733 / doi: 10.1126/sciadv.abe3703
Contact Info: Tony Hu: [email protected]
URL: https://advances.sciencemag.org/content/7/2/eabe3703
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane NPRC, North Carolina State University
Keywords: SARS-CoV-2, portable, ultrasensitive saliva-based virus assay, primates
Summary of Study: CRISPR-FDS determined that mean SARS-Cov-2 RNA levels were 3.6 fold to 124-fold higher, and more stable, in oropharyngeal versus nasal swab samples from nonhuman primates at all time points after infection, suggesting that saliva may represent a more robust diagnostic sample than nasal swabs both early and later in infection.
References: PMID: 33310733 / doi: 10.1126/sciadv.abe3703
Contact Info: Tony Hu: [email protected]
URL: https://advances.sciencemag.org/content/7/2/eabe3703
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Texas Christian University
Keywords: SARS-CoV-2, young and aged animals, viral dynamics, antiviral treatment, primates
Summary of Study: This study finds the viral dynamics of SARS-CoV-2 between young and aged animals and has shown that these differences should be considered when considering antiviral treatment.
References: PMID: 34804559 / doi: 10.1098/rsos.202345
Contact Info: Hana Dobrovolny: [email protected]
URL: https://royalsocietypublishing.org/doi/full/10.1098/rsos.202345?rfr_dat=cr_pub+…
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Texas Christian University
Keywords: SARS-CoV-2, young and aged animals, viral dynamics, antiviral treatment, primates
Summary of Study: This study finds the viral dynamics of SARS-CoV-2 between young and aged animals and has shown that these differences should be considered when considering antiviral treatment.
References: PMID: 34804559 / doi: 10.1098/rsos.202345
Contact Info: Hana Dobrovolny: [email protected]
URL: https://royalsocietypublishing.org/doi/full/10.1098/rsos.202345?rfr_dat=cr_pub+…
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, animal models, viruses, resources, primates
Summary of Study: The SARS-CoV-2/COVID-19 pandemic has significantly increased the demand for specific-pathogen-free (SPF) nonhuman primates (NHPs) for development of vaccines and therapeutics, thus straining the supply of these animals for biomedical research studies. Non-SPF animals, which are available in greater numbers and include well-characterized primate species, should be considered in lieu of limited SPF animals for appropriate research studies.
References: PMID: 34163043 / doi: 10.1038/s41684-021-008102
Contact Info: Miguel Contreras: [email protected]
URL: https://www.nature.com/articles/s41684-021-00810-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, animal models, viruses, resources, primates
Summary of Study: The SARS-CoV-2/COVID-19 pandemic has significantly increased the demand for specific-pathogen-free (SPF) nonhuman primates (NHPs) for development of vaccines and therapeutics, thus straining the supply of these animals for biomedical research studies. Non-SPF animals, which are available in greater numbers and include well-characterized primate species, should be considered in lieu of limited SPF animals for appropriate research studies.
References: PMID: 34163043 / doi: 10.1038/s41684-021-008102
Contact Info: Miguel Contreras: [email protected]
URL: https://www.nature.com/articles/s41684-021-00810-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIAID
Keywords: SARS-CoV-2, virus genomic variants, virus replication, immune response, pathology, primates
Summary of Study: A study of pathogenesis of B.1.1.7 and B.1.351 compared to a SARS-CoV-2 isolate containing the D614G spike substitution showed that B.1.351 was slightly less pathogenic than the other two variants, but there were no differences in virus shedding between the variants that could explain increased transmissibility.
References: PMID: 34678071 / doi: 10.1126/sciadv.abj3627
Contact Info: Emmie de Wit: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.abj3627?url_ver=Z39.88-2003&rfr_id=o…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIAID
Keywords: SARS-CoV-2, virus genomic variants, virus replication, immune response, pathology, primates
Summary of Study: A study of pathogenesis of B.1.1.7 and B.1.351 compared to a SARS-CoV-2 isolate containing the D614G spike substitution showed that B.1.351 was slightly less pathogenic than the other two variants, but there were no differences in virus shedding between the variants that could explain increased transmissibility.
References: PMID: 34678071 / doi: 10.1126/sciadv.abj3627
Contact Info: Emmie de Wit: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.abj3627?url_ver=Z39.88-2003&rfr_id=o…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, pigtail macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Fred Hutchinson Cancer Research Center; University of Washington; Washington National Primate Research Center; NIAID
Keywords: SARS-CoV-2, phage-based deep mutational scanning, epitope targets, spike protein, humans, primates
Summary of Study: Findings suggest that the antibody response to SARS-CoV-2 in macaques shares many features with humans, but with substantial differences in the recognition of certain epitopes and considerable individual variability in antibody escape profiles, suggesting a diverse repertoire of antibodies that can respond to major epitopes in both humans and macaques.
References: PMID: 34909774 / doi: 10.1101/2021.12.01.470697
Contact Info: Julie Overbaugh: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.12.01.470697v1
NHP Species: rhesus macaques, pigtail macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Fred Hutchinson Cancer Research Center; University of Washington; Washington National Primate Research Center; NIAID
Keywords: SARS-CoV-2, phage-based deep mutational scanning, epitope targets, spike protein, humans, primates
Summary of Study: Findings suggest that the antibody response to SARS-CoV-2 in macaques shares many features with humans, but with substantial differences in the recognition of certain epitopes and considerable individual variability in antibody escape profiles, suggesting a diverse repertoire of antibodies that can respond to major epitopes in both humans and macaques.
References: PMID: 34909774 / doi: 10.1101/2021.12.01.470697
Contact Info: Julie Overbaugh: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.12.01.470697v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Yerkes National Primate Research Center, Emory University School of Medicine, Louisiana State University Health Science Center, Texas Children's Center for Vaccine Development, La Jolla Institute for Immunology, and others.
Keywords: SARS-CoV-2, vaccines and adjuvants, immune response, primates
Summary of Study: The adjuvant 3M-052-alum (previously shown to induce better immune responses against HIV) may be a way to improve the efficacy of SARS-CoV-2 vaccines.
References: PMID: 34266981 / doi: 10.1126/sciimmunol.abh3634
Contact Info: Sudhir Pai Kasturi: [email protected]; Maria Elena Bottazzi: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.abh3634?url_ver=Z39.88-2003&rfr_…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Yerkes National Primate Research Center, Emory University School of Medicine, Louisiana State University Health Science Center, Texas Children's Center for Vaccine Development, La Jolla Institute for Immunology, and others.
Keywords: SARS-CoV-2, vaccines and adjuvants, immune response, primates
Summary of Study: The adjuvant 3M-052-alum (previously shown to induce better immune responses against HIV) may be a way to improve the efficacy of SARS-CoV-2 vaccines.
References: PMID: 34266981 / doi: 10.1126/sciimmunol.abh3634
Contact Info: Sudhir Pai Kasturi: [email protected]; Maria Elena Bottazzi: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.abh3634?url_ver=Z39.88-2003&rfr_…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Wuhan Institute of Virology, Tongji Medical College, University of Chinese Academy of Sciences, Wuhan Institute of Biological Products Co.
Keywords: SARS-CoV-2, inactivated vaccine, mice and primates, immune response
Summary of Study: The authors tested the safety, immunogenicity and efficacy of an inactivated vaccine based on on the whole viral particles in human ACE2 transgenic mouse and in NHPs. This inactivated vaccine successfully induced SARS-CoV-2-specific neutralizing antibodies in both models.
References: PMID: 33835391 / doi: 10.1007/s12250-021-00376-w
Contact Info: Xing-Lou Yang: [email protected]; Shuo Shen: [email protected]; Zhi-Ming Yuan: [email protected]
URL: https://link.springer.com/article/10.1007%2Fs12250-021-00376-w
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Wuhan Institute of Virology, Tongji Medical College, University of Chinese Academy of Sciences, Wuhan Institute of Biological Products Co.
Keywords: SARS-CoV-2, inactivated vaccine, mice and primates, immune response
Summary of Study: The authors tested the safety, immunogenicity and efficacy of an inactivated vaccine based on on the whole viral particles in human ACE2 transgenic mouse and in NHPs. This inactivated vaccine successfully induced SARS-CoV-2-specific neutralizing antibodies in both models.
References: PMID: 33835391 / doi: 10.1007/s12250-021-00376-w
Contact Info: Xing-Lou Yang: [email protected]; Shuo Shen: [email protected]; Zhi-Ming Yuan: [email protected]
URL: https://link.springer.com/article/10.1007%2Fs12250-021-00376-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Xiamen University, The University of HongKong, Shantou University, Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, review of the primate models, clinical symptoms, pathogenesis, applications
Summary of Study: Review summarizes the benefits and caveats of NHP models currently available for SARS-CoV-2 and discusses key topics including model optimization, extended application, and clinical translation.
References: PMID: 34490832 / doi: 10.1080/22221751.2021.1976598
Contact Info: Tong Cheng: [email protected]; Ningshao Xia: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1976598
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Xiamen University, The University of HongKong, Shantou University, Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, review of the primate models, clinical symptoms, pathogenesis, applications
Summary of Study: Review summarizes the benefits and caveats of NHP models currently available for SARS-CoV-2 and discusses key topics including model optimization, extended application, and clinical translation.
References: PMID: 34490832 / doi: 10.1080/22221751.2021.1976598
Contact Info: Tong Cheng: [email protected]; Ningshao Xia: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1976598
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Kazan State Medical Academy; Kazan State Medical University; Kazan Federal University
Keywords: SARS-CoV-2, infection, pathogenicity, eye surface, literature meta analysis, primates
Summary of Study: There is a possibility of COVID-19 transmission through the eye surface. Eye protection measures should be undertaken when working with potentially infected patients.
References: PMID: 34410064 / doi: 10.17116/oftalma2021137041104
Contact Info: not provided
URL: https://pubmed.ncbi.nlm.nih.gov/34410064/
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Kazan State Medical Academy; Kazan State Medical University; Kazan Federal University
Keywords: SARS-CoV-2, infection, pathogenicity, eye surface, literature meta analysis, primates
Summary of Study: There is a possibility of COVID-19 transmission through the eye surface. Eye protection measures should be undertaken when working with potentially infected patients.
References: PMID: 34410064 / doi: 10.17116/oftalma2021137041104
Contact Info: not provided
URL: https://pubmed.ncbi.nlm.nih.gov/34410064/
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Melbourne, Monash University
Keywords: SARS-CoV-2, prime-boost protein subunit vaccine, mice and primates
Summary of Study: Both S and RBD vaccines are comparably immunogenic and produced strong serological neutralizing responses in pig-tailed macaques. Overall, immunization with recombinant S immunogens reliably elicits potentially protective humoral immunity at levels in excess of those observed in convalescent human, confirming recombinant S proteins as promising vaccine candidates.
References: PMID: 33658497 / doi: 10.1038/s41467-021-21665-8
Contact Info: Stephen Kent: [email protected]
URL: https://www.nature.com/articles/s41467-021-21665-8
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Melbourne, Monash University
Keywords: SARS-CoV-2, prime-boost protein subunit vaccine, mice and primates
Summary of Study: Both S and RBD vaccines are comparably immunogenic and produced strong serological neutralizing responses in pig-tailed macaques. Overall, immunization with recombinant S immunogens reliably elicits potentially protective humoral immunity at levels in excess of those observed in convalescent human, confirming recombinant S proteins as promising vaccine candidates.
References: PMID: 33658497 / doi: 10.1038/s41467-021-21665-8
Contact Info: Stephen Kent: [email protected]
URL: https://www.nature.com/articles/s41467-021-21665-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Ragon Institute of MGH, MIT, and Harvard; Novavax; University of Duisburg-Essen; MIT; Texas Biomedical Research Institute; University of Maryland School of Medicine; Duke University Medical Center; La Jolla Institute for Immunology; and others
Keywords: SARS-CoV-2, humoral immune response, vaccine-induced antibody fingerprint, protection, primates
Summary of Study: Data presented suggest that a single dose may prevent disease via combined Fc/Fab functions but that two doses may be essential to block further transmission of SARS-CoV-2 and emerging variants.
References: PMID: 34485950 / doi: 10.1016/j.xcrm.2021.100405
Contact Info: Gale Smith: [email protected]; Galit Alter: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009701
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Ragon Institute of MGH, MIT, and Harvard; Novavax; University of Duisburg-Essen; MIT; Texas Biomedical Research Institute; University of Maryland School of Medicine; Duke University Medical Center; La Jolla Institute for Immunology; and others
Keywords: SARS-CoV-2, humoral immune response, vaccine-induced antibody fingerprint, protection, primates
Summary of Study: Data presented suggest that a single dose may prevent disease via combined Fc/Fab functions but that two doses may be essential to block further transmission of SARS-CoV-2 and emerging variants.
References: PMID: 34485950 / doi: 10.1016/j.xcrm.2021.100405
Contact Info: Gale Smith: [email protected]; Galit Alter: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009701
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Janssen Vaccines & Prevention B.V.; Harvard Medical School; Lucidity Biomedical Consulting; Ragon Institute of MGH, MIT and Harvard; Massachusetts Consortium on Pathogen Readiness
Keywords: SARS-CoV-2, adenovirus vector, immunogenicity, protective efficacy, immune response, primates
Summary of Study: Ad26.COV2.S vaccine confers durable protection against replication of SARS-CoV-2 in the lungs that is predicted by the levels of Spike-binding and neutralizing antibodies, indicating that Ad26.COV2.S could confer durable protection in humans and immunological correlates of protection may enable the prediction of durability of protection.
References: PMID: 34620860 / doi: 10.1038/s41467-021-26117-x
Contact Info: Roland Zahn: [email protected]
URL: https://www.nature.com/articles/s41467-021-26117-x
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Janssen Vaccines & Prevention B.V.; Harvard Medical School; Lucidity Biomedical Consulting; Ragon Institute of MGH, MIT and Harvard; Massachusetts Consortium on Pathogen Readiness
Keywords: SARS-CoV-2, adenovirus vector, immunogenicity, protective efficacy, immune response, primates
Summary of Study: Ad26.COV2.S vaccine confers durable protection against replication of SARS-CoV-2 in the lungs that is predicted by the levels of Spike-binding and neutralizing antibodies, indicating that Ad26.COV2.S could confer durable protection in humans and immunological correlates of protection may enable the prediction of durability of protection.
References: PMID: 34620860 / doi: 10.1038/s41467-021-26117-x
Contact Info: Roland Zahn: [email protected]
URL: https://www.nature.com/articles/s41467-021-26117-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: ReiThera Srl, University of Nottingham, National Institute for Infectious Diseases "Lazzaro Spallanzani"
Keywords: SARS-CoV-2, replication-defective gorilla adenovirus-vectored vaccine, immune response, mice and primates
Summary of Study: Pre-fusion stabilized Spike antigen is superior to the wild type in inducing ACE2-interfering, SARS-CoV-2-neutralizing antibodies.
References: PMID: 33895322 / doi: 10.1016/j.ymthe.2021.04.022
Contact Info: Alessandra Vitelli: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1525001621002100?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: ReiThera Srl, University of Nottingham, National Institute for Infectious Diseases "Lazzaro Spallanzani"
Keywords: SARS-CoV-2, replication-defective gorilla adenovirus-vectored vaccine, immune response, mice and primates
Summary of Study: Pre-fusion stabilized Spike antigen is superior to the wild type in inducing ACE2-interfering, SARS-CoV-2-neutralizing antibodies.
References: PMID: 33895322 / doi: 10.1016/j.ymthe.2021.04.022
Contact Info: Alessandra Vitelli: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1525001621002100?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Duke University School of Medicine, University of North Carolina at Chapel Hill, FDA, and others
Keywords: SARS-CoV-2, nanoparticles, receptor-binding domain of SARS-CoV-2, immune response, primates
Summary of Study: The immunization of macaques with nanoparticles conjugated with the receptor-binding domain of SARS-CoV-2, and adjuvanted with 3M-052 and alum, elicits cross-neutralizing antibody responses against bat coronaviruses, SARS-CoV and SARS-CoV-2. Nucleoside-modified mRNAs that encode a stabilized transmembrane spike or monomeric receptor-binding domain also induced cross-neutralizing antibody responses against SARS-CoV and bat coronaviruses.
References: PMID: 33971664 / doi: 10.1038/s41586-021-03594-0
Contact Info: Kevin Saunders: [email protected]; Barton Haynes: [email protected]
URL: https://www.nature.com/articles/s41586-021-03594-0
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Duke University School of Medicine, University of North Carolina at Chapel Hill, FDA, and others
Keywords: SARS-CoV-2, nanoparticles, receptor-binding domain of SARS-CoV-2, immune response, primates
Summary of Study: The immunization of macaques with nanoparticles conjugated with the receptor-binding domain of SARS-CoV-2, and adjuvanted with 3M-052 and alum, elicits cross-neutralizing antibody responses against bat coronaviruses, SARS-CoV and SARS-CoV-2. Nucleoside-modified mRNAs that encode a stabilized transmembrane spike or monomeric receptor-binding domain also induced cross-neutralizing antibody responses against SARS-CoV and bat coronaviruses.
References: PMID: 33971664 / doi: 10.1038/s41586-021-03594-0
Contact Info: Kevin Saunders: [email protected]; Barton Haynes: [email protected]
URL: https://www.nature.com/articles/s41586-021-03594-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID; Emory University; BIOQUAL, Inc.; Moderna, Inc.; Johns Hopkins University
Keywords: SARS-CoV-2, virus genomic variants, boost, immune response, primates
Summary of Study: Homologous mRNA-1273 boost can significantly improve both the breadth and potency of neutralizing antibody responses and confer protection against upper and lower airway infection to a heterologous challenge virus, which is relatively resistant to in vitro neutralization.
References: PMID: 34672695 / doi: 10.1126/science.abl8912
Contact Info: Robert Seder: [email protected]; Barney Graham: [email protected]
URL: https://www.science.org/doi/10.1126/science.abl8912?url_ver=Z39.88-2003&rfr_id=…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID; Emory University; BIOQUAL, Inc.; Moderna, Inc.; Johns Hopkins University
Keywords: SARS-CoV-2, virus genomic variants, boost, immune response, primates
Summary of Study: Homologous mRNA-1273 boost can significantly improve both the breadth and potency of neutralizing antibody responses and confer protection against upper and lower airway infection to a heterologous challenge virus, which is relatively resistant to in vitro neutralization.
References: PMID: 34672695 / doi: 10.1126/science.abl8912
Contact Info: Robert Seder: [email protected]; Barney Graham: [email protected]
URL: https://www.science.org/doi/10.1126/science.abl8912?url_ver=Z39.88-2003&rfr_id=…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIH, University of Oxford, NIAID, Icahn School of Medicine at Mount Sinai
Keywords: SARS-CoV-2, adenovirus-based vaccine, intranasal administration, hamsters, primates
Summary of Study: Intranasal vaccination with ChAdOx1 nCoV-19/AZD1222 reduced virus concentrations in nasal swabs in two different SARS-CoV-2 animal models, warranting further investigation as a potential vaccination route for COVID-19 vaccines.
References: PMID: 34315826 / doi: 10.1126/scitranslmed.abh0755
Contact Info: Vincent Munster: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abh0755?url_ver=Z39.88-2003&rf…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIH, University of Oxford, NIAID, Icahn School of Medicine at Mount Sinai
Keywords: SARS-CoV-2, adenovirus-based vaccine, intranasal administration, hamsters, primates
Summary of Study: Intranasal vaccination with ChAdOx1 nCoV-19/AZD1222 reduced virus concentrations in nasal swabs in two different SARS-CoV-2 animal models, warranting further investigation as a potential vaccination route for COVID-19 vaccines.
References: PMID: 34315826 / doi: 10.1126/scitranslmed.abh0755
Contact Info: Vincent Munster: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abh0755?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Johns Hopkins School of Medicine; Yale University School of Medicine
Keywords: SARS-CoV-2, several animal species, immunological response, primates
Summary of Study: This review discusses small and large animal model studies previously used in SARS-CoV-2 research that may be useful in elucidating the immunological contributions to hallmark syndromes observed with COVID-19.
References: PMID: 33914873 / doi: 10.1093/ilar/ilab010
Contact Info: Rebecca Veenhuis: [email protected]
URL: https://academic.oup.com/ilarjournal/advance-article/doi/10.1093/ilar/ilab010/6…
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Johns Hopkins School of Medicine; Yale University School of Medicine
Keywords: SARS-CoV-2, several animal species, immunological response, primates
Summary of Study: This review discusses small and large animal model studies previously used in SARS-CoV-2 research that may be useful in elucidating the immunological contributions to hallmark syndromes observed with COVID-19.
References: PMID: 33914873 / doi: 10.1093/ilar/ilab010
Contact Info: Rebecca Veenhuis: [email protected]
URL: https://academic.oup.com/ilarjournal/advance-article/doi/10.1093/ilar/ilab010/6…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Universite de Paris, Institut Pasteur and others
Keywords: SARS-CoV-2, mathematical model, viral dynamics, immune response, viral clearance, primates
Summary of Study: Results provide estimates of SARS-CoV-2 viral kinetic parameters in an experimental model of mild infection and they provide means to assess the efficacy of future antiviral treatments.
References: PMID: 33730053 / doi: 10.1371/journal.pcbi.1008785
Contact Info: Antonio Goncalves: [email protected]
URL: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008785
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Universite de Paris, Institut Pasteur and others
Keywords: SARS-CoV-2, mathematical model, viral dynamics, immune response, viral clearance, primates
Summary of Study: Results provide estimates of SARS-CoV-2 viral kinetic parameters in an experimental model of mild infection and they provide means to assess the efficacy of future antiviral treatments.
References: PMID: 33730053 / doi: 10.1371/journal.pcbi.1008785
Contact Info: Antonio Goncalves: [email protected]
URL: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008785
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: NCI/NIH
Keywords: SARS-CoV-2, ACE2, type I interferon, pathology, primates
Summary of Study: Type I interferon mediates an important innate immune response against viral infection by directly inhibiting viral replication. It also bridges innate to adaptive immunity for long-term protection against viral reinfections.
References: PMID: 34149696 / doi: 10.3389/fimmu.2021.658428
Contact Info: Yongjun Sui: [email protected]; Jay Berzofsky: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.658428/full
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: NCI/NIH
Keywords: SARS-CoV-2, ACE2, type I interferon, pathology, primates
Summary of Study: Type I interferon mediates an important innate immune response against viral infection by directly inhibiting viral replication. It also bridges innate to adaptive immunity for long-term protection against viral reinfections.
References: PMID: 34149696 / doi: 10.3389/fimmu.2021.658428
Contact Info: Yongjun Sui: [email protected]; Jay Berzofsky: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.658428/full
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Amsterdam; University Paris-Saclay, Inserm, CEA; AIMM Therapeutics BV; J&S Preclinical Solutions; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, variants of concern, third vaccination, mice, rabbits, primates
Summary of Study: A third immunization improves neutralizing antibody titers against the variants-of-concern (Alpha, Beta, Gamma, and Delta).
References: PMID: 34862406 / doi: 10.1038/s41541-021-00411-7
Contact Info: Rogier Sanders: [email protected]
URL: https://www.nature.com/articles/s41541-021-00411-7
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Amsterdam; University Paris-Saclay, Inserm, CEA; AIMM Therapeutics BV; J&S Preclinical Solutions; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, variants of concern, third vaccination, mice, rabbits, primates
Summary of Study: A third immunization improves neutralizing antibody titers against the variants-of-concern (Alpha, Beta, Gamma, and Delta).
References: PMID: 34862406 / doi: 10.1038/s41541-021-00411-7
Contact Info: Rogier Sanders: [email protected]
URL: https://www.nature.com/articles/s41541-021-00411-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets, howler monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Instituto Federal do Norte de Minas Gerais, Brazil; Universidade Federal dos Vales do Jequitinhonha e Mucuri, Brazil; Centro Estadual de Vigilancia em Saude; Universidade de Brasilia; Universidade Federal de Minas Gerais; State University of Santa Cruz; Universidade Federal de Tocantins
Keywords: SARS-CoV-2, wild animals, RT-qPCR, primates
Summary of Study: 51 NHPs were examined for signs of SARS-CoV-2; 89 samples of various tissues were analyzed, with no SARS-CoV-2 positive samples detected, regardless of NHP species, tissue, habitat, municipalities or state/biome tested.
References: PMID: 34843021 / doi: 10.1007/s10393-021-01569-1
Contact Info: Danilo Bretas de Oliveira: [email protected]
URL: https://link.springer.com/article/10.1007%2Fs10393-021-01569-1
NHP Species: marmosets, howler monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Instituto Federal do Norte de Minas Gerais, Brazil; Universidade Federal dos Vales do Jequitinhonha e Mucuri, Brazil; Centro Estadual de Vigilancia em Saude; Universidade de Brasilia; Universidade Federal de Minas Gerais; State University of Santa Cruz; Universidade Federal de Tocantins
Keywords: SARS-CoV-2, wild animals, RT-qPCR, primates
Summary of Study: 51 NHPs were examined for signs of SARS-CoV-2; 89 samples of various tissues were analyzed, with no SARS-CoV-2 positive samples detected, regardless of NHP species, tissue, habitat, municipalities or state/biome tested.
References: PMID: 34843021 / doi: 10.1007/s10393-021-01569-1
Contact Info: Danilo Bretas de Oliveira: [email protected]
URL: https://link.springer.com/article/10.1007%2Fs10393-021-01569-1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: California National Primate Research Center, UC Davis School of Medicine, The Rockefeller University, UC Davis School of Veterinary Medicine, DMID/NIAID/NIH, Howard Hughes Medical Institute
Keywords: SARS-CoV-2, therapeutic interventions, neutralizing monoclonal antibodies, pathology, primates
Summary of Study: Study provides proof-of-concept in support of further clinical development of monoclonal antibodies C135-LS and C144-LS against COVID-19 during early infection.
References: PMID: 34228761 / doi: 10.1371/journal.ppat.1009688
Contact Info: Koen Van Rompay: [email protected]; Michel Nussenzweig: [email protected]; J. Rachel Reader: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009688
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: California National Primate Research Center, UC Davis School of Medicine, The Rockefeller University, UC Davis School of Veterinary Medicine, DMID/NIAID/NIH, Howard Hughes Medical Institute
Keywords: SARS-CoV-2, therapeutic interventions, neutralizing monoclonal antibodies, pathology, primates
Summary of Study: Study provides proof-of-concept in support of further clinical development of monoclonal antibodies C135-LS and C144-LS against COVID-19 during early infection.
References: PMID: 34228761 / doi: 10.1371/journal.ppat.1009688
Contact Info: Koen Van Rompay: [email protected]; Michel Nussenzweig: [email protected]; J. Rachel Reader: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009688
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Agricultural Sciences; National Research Center for Exotic Animal Diseases, China Animal Health and Epidemiology Center
Keywords: SARS-CoV-2, meta analysis, review of the animal models, vaccination, mice, hamsters, ferrets, primates
Summary of Study: This review summarizes the landscape of animal models for COVID-19 vaccine evaluation and advanced vaccines with an efficacy range from about 50% to more than 95%.
References: PMID: 34696190 / doi: 10.3390/vaccines9101082
Contact Info: Yuwei Gao: [email protected]; Feihu Yan: [email protected]; Songtao Yang: [email protected]
URL: https://www.mdpi.com/2076-393X/9/10/1082
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Agricultural Sciences; National Research Center for Exotic Animal Diseases, China Animal Health and Epidemiology Center
Keywords: SARS-CoV-2, meta analysis, review of the animal models, vaccination, mice, hamsters, ferrets, primates
Summary of Study: This review summarizes the landscape of animal models for COVID-19 vaccine evaluation and advanced vaccines with an efficacy range from about 50% to more than 95%.
References: PMID: 34696190 / doi: 10.3390/vaccines9101082
Contact Info: Yuwei Gao: [email protected]; Feihu Yan: [email protected]; Songtao Yang: [email protected]
URL: https://www.mdpi.com/2076-393X/9/10/1082
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Institute of Advanced Study in Science and Technology (India), Biodiversity Research Center, Academic Sinica (Taipei) and others
Keywords: SARS-CoV-2, ACE2 variants, binding affinity of ACE2 to S-protein, multiple species, humans and primates
Summary of Study: Binding affinity of ACE2 to S-protein was studied in various NHP species. Based on findings, the authors propose that the common ancestor of primates was strongly resistant to and that of New World monkeys was completely resistant to SARS-CoV-2; whereas apes and Old World monkeys, like most humans, are susceptible. This study increases our understanding of the differences in susceptibility to SARS-CV-2 infection among primates.
References: PMID: 33674876 / doi: 10.1093/molbev/msab060
Contact Info: Yan Yuan Tseng: [email protected]; Lily Hui-Ching Wang: [email protected]
URL: https://academic.oup.com/mbe/advance-article/doi/10.1093/molbev/msab060/6154855
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Institute of Advanced Study in Science and Technology (India), Biodiversity Research Center, Academic Sinica (Taipei) and others
Keywords: SARS-CoV-2, ACE2 variants, binding affinity of ACE2 to S-protein, multiple species, humans and primates
Summary of Study: Binding affinity of ACE2 to S-protein was studied in various NHP species. Based on findings, the authors propose that the common ancestor of primates was strongly resistant to and that of New World monkeys was completely resistant to SARS-CoV-2; whereas apes and Old World monkeys, like most humans, are susceptible. This study increases our understanding of the differences in susceptibility to SARS-CV-2 infection among primates.
References: PMID: 33674876 / doi: 10.1093/molbev/msab060
Contact Info: Yan Yuan Tseng: [email protected]; Lily Hui-Ching Wang: [email protected]
URL: https://academic.oup.com/mbe/advance-article/doi/10.1093/molbev/msab060/6154855
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Beijing Institute of Microbiology & Immunology; Institute of Military Veterinary, Academic of Military Medical Sciences
Keywords: SARS-CoV-2, recombinant vaccine, efficacy of RBD-Fc Vacc, mice and primates
Summary of Study: A new recombinant vaccine made by fusing the SARS-CoV-2 RBD with the Fc fragment of human IgG1induced a potent immune response, protecting cynomolgus macaques against SARS-CoV-2 infection.
References: PMID: 33731916 / doi: 10.1038/s41423-021-00658-z
Contact Info: Yansong Sun: [email protected]; Yuwei Gao: [email protected]
URL: https://www.nature.com/articles/s41423-021-00658-z
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Beijing Institute of Microbiology & Immunology; Institute of Military Veterinary, Academic of Military Medical Sciences
Keywords: SARS-CoV-2, recombinant vaccine, efficacy of RBD-Fc Vacc, mice and primates
Summary of Study: A new recombinant vaccine made by fusing the SARS-CoV-2 RBD with the Fc fragment of human IgG1induced a potent immune response, protecting cynomolgus macaques against SARS-CoV-2 infection.
References: PMID: 33731916 / doi: 10.1038/s41423-021-00658-z
Contact Info: Yansong Sun: [email protected]; Yuwei Gao: [email protected]
URL: https://www.nature.com/articles/s41423-021-00658-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Yerkes National Primate Research Center, Duke University School of Medicine, Harvard
Keywords: SARS-CoV-2, modified vaccinia Ankara vector-based vaccine, immune response, pathology, primates
Summary of Study: MVA/S vaccination can provide protection from intranasal and intratracheal SARS-CoV-2 challenge and support further development of this vaccine to test immunogenicity and efficacy in humans.
References: PMID: 33631118 / doi: 10.1016/j.immuni.2021.02.001
Contact Info: Rama Rao Amara: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S107476132100042X?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Yerkes National Primate Research Center, Duke University School of Medicine, Harvard
Keywords: SARS-CoV-2, modified vaccinia Ankara vector-based vaccine, immune response, pathology, primates
Summary of Study: MVA/S vaccination can provide protection from intranasal and intratracheal SARS-CoV-2 challenge and support further development of this vaccine to test immunogenicity and efficacy in humans.
References: PMID: 33631118 / doi: 10.1016/j.immuni.2021.02.001
Contact Info: Rama Rao Amara: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S107476132100042X?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Institute of Medical Biology, Chinese Academy of Medical Sciences & U. Mass.
Keywords: SARS-CoV-2, DNA and protein vaccine combination, primates
Summary of Study: The novel combination of a DNA vaccine encoding the full-length Spike (S) protein of SARS-CoV-2 and a recombinant S1 protein vaccine elicited full protection against the challenge of SARS-CoV-2 in an NHP model.
References: PMID: 33555988 / doi: 10.1080/22221751.2021.1887767
Contact Info: Wei Cun: [email protected] / Shan Lu: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1887767
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Institute of Medical Biology, Chinese Academy of Medical Sciences & U. Mass.
Keywords: SARS-CoV-2, DNA and protein vaccine combination, primates
Summary of Study: The novel combination of a DNA vaccine encoding the full-length Spike (S) protein of SARS-CoV-2 and a recombinant S1 protein vaccine elicited full protection against the challenge of SARS-CoV-2 in an NHP model.
References: PMID: 33555988 / doi: 10.1080/22221751.2021.1887767
Contact Info: Wei Cun: [email protected] / Shan Lu: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1887767
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Indian Council of Medical Research-National Institute of Virology
Keywords: SARS-CoV-2, inactivated SARS-CoV-2 vaccine candidate, immunogenicity, efficacy, primates
Summary of Study: A two-dose regimen of vaccine candidate BBV152 with adjuvant B induces a significant immune response and provides effective protection in rhesus macaques challenged with SARS-CoV-2.
References: PMID: 33654090 / doi: 10.1038/s41467-021-21639-w
Contact Info: Balram Bhargava: [email protected]
URL: https://www.nature.com/articles/s41467-021-21639-w
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Indian Council of Medical Research-National Institute of Virology
Keywords: SARS-CoV-2, inactivated SARS-CoV-2 vaccine candidate, immunogenicity, efficacy, primates
Summary of Study: A two-dose regimen of vaccine candidate BBV152 with adjuvant B induces a significant immune response and provides effective protection in rhesus macaques challenged with SARS-CoV-2.
References: PMID: 33654090 / doi: 10.1038/s41467-021-21639-w
Contact Info: Balram Bhargava: [email protected]
URL: https://www.nature.com/articles/s41467-021-21639-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Texas Medical Branch, Pfizer
Keywords: SARS-CoV-2, vaccine-elicited immunity, virus variant, primates
Summary of Study: The D614G mutation modestly reduced SARS-CoV-2 neutralization by BNT162b2 vaccine-elicited mouse, rhesus, and human sera, concurring with the 95% vaccine efficacy observed in clinical trial.
References: PMID: 33767200 / doi: 10.1038/s41541-021-00313-8
Contact Info: Philip Dormitzer: philip,[email protected]
URL: https://www.nature.com/articles/s41541-021-00313-8
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Texas Medical Branch, Pfizer
Keywords: SARS-CoV-2, vaccine-elicited immunity, virus variant, primates
Summary of Study: The D614G mutation modestly reduced SARS-CoV-2 neutralization by BNT162b2 vaccine-elicited mouse, rhesus, and human sera, concurring with the 95% vaccine efficacy observed in clinical trial.
References: PMID: 33767200 / doi: 10.1038/s41541-021-00313-8
Contact Info: Philip Dormitzer: philip,[email protected]
URL: https://www.nature.com/articles/s41541-021-00313-8