Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Texas Christian University
Keywords: SARS-CoV-2, young and aged animals, viral dynamics, antiviral treatment, primates
Summary of Study: This study finds the viral dynamics of SARS-CoV-2 between young and aged animals and has shown that these differences should be considered when considering antiviral treatment.
References: PMID: 34804559 / doi: 10.1098/rsos.202345
Contact Info: Hana Dobrovolny: [email protected]
URL: https://royalsocietypublishing.org/doi/full/10.1098/rsos.202345?rfr_dat=cr_pub+…
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Texas Christian University
Keywords: SARS-CoV-2, young and aged animals, viral dynamics, antiviral treatment, primates
Summary of Study: This study finds the viral dynamics of SARS-CoV-2 between young and aged animals and has shown that these differences should be considered when considering antiviral treatment.
References: PMID: 34804559 / doi: 10.1098/rsos.202345
Contact Info: Hana Dobrovolny: [email protected]
URL: https://royalsocietypublishing.org/doi/full/10.1098/rsos.202345?rfr_dat=cr_pub+…
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, animal models, viruses, resources, primates
Summary of Study: The SARS-CoV-2/COVID-19 pandemic has significantly increased the demand for specific-pathogen-free (SPF) nonhuman primates (NHPs) for development of vaccines and therapeutics, thus straining the supply of these animals for biomedical research studies. Non-SPF animals, which are available in greater numbers and include well-characterized primate species, should be considered in lieu of limited SPF animals for appropriate research studies.
References: PMID: 34163043 / doi: 10.1038/s41684-021-008102
Contact Info: Miguel Contreras: [email protected]
URL: https://www.nature.com/articles/s41684-021-00810-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, animal models, viruses, resources, primates
Summary of Study: The SARS-CoV-2/COVID-19 pandemic has significantly increased the demand for specific-pathogen-free (SPF) nonhuman primates (NHPs) for development of vaccines and therapeutics, thus straining the supply of these animals for biomedical research studies. Non-SPF animals, which are available in greater numbers and include well-characterized primate species, should be considered in lieu of limited SPF animals for appropriate research studies.
References: PMID: 34163043 / doi: 10.1038/s41684-021-008102
Contact Info: Miguel Contreras: [email protected]
URL: https://www.nature.com/articles/s41684-021-00810-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIAID
Keywords: SARS-CoV-2, virus genomic variants, virus replication, immune response, pathology, primates
Summary of Study: A study of pathogenesis of B.1.1.7 and B.1.351 compared to a SARS-CoV-2 isolate containing the D614G spike substitution showed that B.1.351 was slightly less pathogenic than the other two variants, but there were no differences in virus shedding between the variants that could explain increased transmissibility.
References: PMID: 34678071 / doi: 10.1126/sciadv.abj3627
Contact Info: Emmie de Wit: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.abj3627?url_ver=Z39.88-2003&rfr_id=o…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIAID
Keywords: SARS-CoV-2, virus genomic variants, virus replication, immune response, pathology, primates
Summary of Study: A study of pathogenesis of B.1.1.7 and B.1.351 compared to a SARS-CoV-2 isolate containing the D614G spike substitution showed that B.1.351 was slightly less pathogenic than the other two variants, but there were no differences in virus shedding between the variants that could explain increased transmissibility.
References: PMID: 34678071 / doi: 10.1126/sciadv.abj3627
Contact Info: Emmie de Wit: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.abj3627?url_ver=Z39.88-2003&rfr_id=o…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, pigtail macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Fred Hutchinson Cancer Research Center; University of Washington; Washington National Primate Research Center; NIAID
Keywords: SARS-CoV-2, phage-based deep mutational scanning, epitope targets, spike protein, humans, primates
Summary of Study: Findings suggest that the antibody response to SARS-CoV-2 in macaques shares many features with humans, but with substantial differences in the recognition of certain epitopes and considerable individual variability in antibody escape profiles, suggesting a diverse repertoire of antibodies that can respond to major epitopes in both humans and macaques.
References: PMID: 34909774 / doi: 10.1101/2021.12.01.470697
Contact Info: Julie Overbaugh: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.12.01.470697v1
NHP Species: rhesus macaques, pigtail macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Fred Hutchinson Cancer Research Center; University of Washington; Washington National Primate Research Center; NIAID
Keywords: SARS-CoV-2, phage-based deep mutational scanning, epitope targets, spike protein, humans, primates
Summary of Study: Findings suggest that the antibody response to SARS-CoV-2 in macaques shares many features with humans, but with substantial differences in the recognition of certain epitopes and considerable individual variability in antibody escape profiles, suggesting a diverse repertoire of antibodies that can respond to major epitopes in both humans and macaques.
References: PMID: 34909774 / doi: 10.1101/2021.12.01.470697
Contact Info: Julie Overbaugh: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.12.01.470697v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Yerkes National Primate Research Center, Emory University School of Medicine, Louisiana State University Health Science Center, Texas Children's Center for Vaccine Development, La Jolla Institute for Immunology, and others.
Keywords: SARS-CoV-2, vaccines and adjuvants, immune response, primates
Summary of Study: The adjuvant 3M-052-alum (previously shown to induce better immune responses against HIV) may be a way to improve the efficacy of SARS-CoV-2 vaccines.
References: PMID: 34266981 / doi: 10.1126/sciimmunol.abh3634
Contact Info: Sudhir Pai Kasturi: [email protected]; Maria Elena Bottazzi: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.abh3634?url_ver=Z39.88-2003&rfr_…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Yerkes National Primate Research Center, Emory University School of Medicine, Louisiana State University Health Science Center, Texas Children's Center for Vaccine Development, La Jolla Institute for Immunology, and others.
Keywords: SARS-CoV-2, vaccines and adjuvants, immune response, primates
Summary of Study: The adjuvant 3M-052-alum (previously shown to induce better immune responses against HIV) may be a way to improve the efficacy of SARS-CoV-2 vaccines.
References: PMID: 34266981 / doi: 10.1126/sciimmunol.abh3634
Contact Info: Sudhir Pai Kasturi: [email protected]; Maria Elena Bottazzi: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.abh3634?url_ver=Z39.88-2003&rfr_…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Wuhan Institute of Virology, Tongji Medical College, University of Chinese Academy of Sciences, Wuhan Institute of Biological Products Co.
Keywords: SARS-CoV-2, inactivated vaccine, mice and primates, immune response
Summary of Study: The authors tested the safety, immunogenicity and efficacy of an inactivated vaccine based on on the whole viral particles in human ACE2 transgenic mouse and in NHPs. This inactivated vaccine successfully induced SARS-CoV-2-specific neutralizing antibodies in both models.
References: PMID: 33835391 / doi: 10.1007/s12250-021-00376-w
Contact Info: Xing-Lou Yang: [email protected]; Shuo Shen: [email protected]; Zhi-Ming Yuan: [email protected]
URL: https://link.springer.com/article/10.1007%2Fs12250-021-00376-w
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Wuhan Institute of Virology, Tongji Medical College, University of Chinese Academy of Sciences, Wuhan Institute of Biological Products Co.
Keywords: SARS-CoV-2, inactivated vaccine, mice and primates, immune response
Summary of Study: The authors tested the safety, immunogenicity and efficacy of an inactivated vaccine based on on the whole viral particles in human ACE2 transgenic mouse and in NHPs. This inactivated vaccine successfully induced SARS-CoV-2-specific neutralizing antibodies in both models.
References: PMID: 33835391 / doi: 10.1007/s12250-021-00376-w
Contact Info: Xing-Lou Yang: [email protected]; Shuo Shen: [email protected]; Zhi-Ming Yuan: [email protected]
URL: https://link.springer.com/article/10.1007%2Fs12250-021-00376-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Xiamen University, The University of HongKong, Shantou University, Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, review of the primate models, clinical symptoms, pathogenesis, applications
Summary of Study: Review summarizes the benefits and caveats of NHP models currently available for SARS-CoV-2 and discusses key topics including model optimization, extended application, and clinical translation.
References: PMID: 34490832 / doi: 10.1080/22221751.2021.1976598
Contact Info: Tong Cheng: [email protected]; Ningshao Xia: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1976598
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Xiamen University, The University of HongKong, Shantou University, Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, review of the primate models, clinical symptoms, pathogenesis, applications
Summary of Study: Review summarizes the benefits and caveats of NHP models currently available for SARS-CoV-2 and discusses key topics including model optimization, extended application, and clinical translation.
References: PMID: 34490832 / doi: 10.1080/22221751.2021.1976598
Contact Info: Tong Cheng: [email protected]; Ningshao Xia: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1976598
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Kazan State Medical Academy; Kazan State Medical University; Kazan Federal University
Keywords: SARS-CoV-2, infection, pathogenicity, eye surface, literature meta analysis, primates
Summary of Study: There is a possibility of COVID-19 transmission through the eye surface. Eye protection measures should be undertaken when working with potentially infected patients.
References: PMID: 34410064 / doi: 10.17116/oftalma2021137041104
Contact Info: not provided
URL: https://pubmed.ncbi.nlm.nih.gov/34410064/
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Kazan State Medical Academy; Kazan State Medical University; Kazan Federal University
Keywords: SARS-CoV-2, infection, pathogenicity, eye surface, literature meta analysis, primates
Summary of Study: There is a possibility of COVID-19 transmission through the eye surface. Eye protection measures should be undertaken when working with potentially infected patients.
References: PMID: 34410064 / doi: 10.17116/oftalma2021137041104
Contact Info: not provided
URL: https://pubmed.ncbi.nlm.nih.gov/34410064/
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Melbourne, Monash University
Keywords: SARS-CoV-2, prime-boost protein subunit vaccine, mice and primates
Summary of Study: Both S and RBD vaccines are comparably immunogenic and produced strong serological neutralizing responses in pig-tailed macaques. Overall, immunization with recombinant S immunogens reliably elicits potentially protective humoral immunity at levels in excess of those observed in convalescent human, confirming recombinant S proteins as promising vaccine candidates.
References: PMID: 33658497 / doi: 10.1038/s41467-021-21665-8
Contact Info: Stephen Kent: [email protected]
URL: https://www.nature.com/articles/s41467-021-21665-8
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Melbourne, Monash University
Keywords: SARS-CoV-2, prime-boost protein subunit vaccine, mice and primates
Summary of Study: Both S and RBD vaccines are comparably immunogenic and produced strong serological neutralizing responses in pig-tailed macaques. Overall, immunization with recombinant S immunogens reliably elicits potentially protective humoral immunity at levels in excess of those observed in convalescent human, confirming recombinant S proteins as promising vaccine candidates.
References: PMID: 33658497 / doi: 10.1038/s41467-021-21665-8
Contact Info: Stephen Kent: [email protected]
URL: https://www.nature.com/articles/s41467-021-21665-8
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Akston Biosciences Corp.; Biomere Biomedical Research Models; Feigin ABSL-3 Facility, Baylor College of Medicine; BIOQUAL; California National Primate Research Center; Sinclair Research Center; Pharmaceutical Research Associates Group B.V.
Keywords: SARS-CoV-2, viral spike protein, immunogenicity, prophylaxis, Fc-fusion, mice, primates
Summary of Study: Preclinical studies support the initiation of Phase I clinical studies with adjuvanted AKS-452 with the expectation that this room-temperature stable, Fc-fusion subunit vaccine can be rapidly and inexpensively manufactured to provide billions of doses per year especially in regions where the cold-chain is difficult to maintain.
References: PMID: 34642088 / doi: 10.1016/j.vaccine.2021.09.077
Contact Info: Todd Zion: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21012949?via%3Dihub
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Akston Biosciences Corp.; Biomere Biomedical Research Models; Feigin ABSL-3 Facility, Baylor College of Medicine; BIOQUAL; California National Primate Research Center; Sinclair Research Center; Pharmaceutical Research Associates Group B.V.
Keywords: SARS-CoV-2, viral spike protein, immunogenicity, prophylaxis, Fc-fusion, mice, primates
Summary of Study: Preclinical studies support the initiation of Phase I clinical studies with adjuvanted AKS-452 with the expectation that this room-temperature stable, Fc-fusion subunit vaccine can be rapidly and inexpensively manufactured to provide billions of doses per year especially in regions where the cold-chain is difficult to maintain.
References: PMID: 34642088 / doi: 10.1016/j.vaccine.2021.09.077
Contact Info: Todd Zion: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21012949?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: ReiThera Srl, University of Nottingham, National Institute for Infectious Diseases "Lazzaro Spallanzani"
Keywords: SARS-CoV-2, replication-defective gorilla adenovirus-vectored vaccine, immune response, mice and primates
Summary of Study: Pre-fusion stabilized Spike antigen is superior to the wild type in inducing ACE2-interfering, SARS-CoV-2-neutralizing antibodies.
References: PMID: 33895322 / doi: 10.1016/j.ymthe.2021.04.022
Contact Info: Alessandra Vitelli: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1525001621002100?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: ReiThera Srl, University of Nottingham, National Institute for Infectious Diseases "Lazzaro Spallanzani"
Keywords: SARS-CoV-2, replication-defective gorilla adenovirus-vectored vaccine, immune response, mice and primates
Summary of Study: Pre-fusion stabilized Spike antigen is superior to the wild type in inducing ACE2-interfering, SARS-CoV-2-neutralizing antibodies.
References: PMID: 33895322 / doi: 10.1016/j.ymthe.2021.04.022
Contact Info: Alessandra Vitelli: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1525001621002100?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Duke University School of Medicine, University of North Carolina at Chapel Hill, FDA, and others
Keywords: SARS-CoV-2, nanoparticles, receptor-binding domain of SARS-CoV-2, immune response, primates
Summary of Study: The immunization of macaques with nanoparticles conjugated with the receptor-binding domain of SARS-CoV-2, and adjuvanted with 3M-052 and alum, elicits cross-neutralizing antibody responses against bat coronaviruses, SARS-CoV and SARS-CoV-2. Nucleoside-modified mRNAs that encode a stabilized transmembrane spike or monomeric receptor-binding domain also induced cross-neutralizing antibody responses against SARS-CoV and bat coronaviruses.
References: PMID: 33971664 / doi: 10.1038/s41586-021-03594-0
Contact Info: Kevin Saunders: [email protected]; Barton Haynes: [email protected]
URL: https://www.nature.com/articles/s41586-021-03594-0
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Duke University School of Medicine, University of North Carolina at Chapel Hill, FDA, and others
Keywords: SARS-CoV-2, nanoparticles, receptor-binding domain of SARS-CoV-2, immune response, primates
Summary of Study: The immunization of macaques with nanoparticles conjugated with the receptor-binding domain of SARS-CoV-2, and adjuvanted with 3M-052 and alum, elicits cross-neutralizing antibody responses against bat coronaviruses, SARS-CoV and SARS-CoV-2. Nucleoside-modified mRNAs that encode a stabilized transmembrane spike or monomeric receptor-binding domain also induced cross-neutralizing antibody responses against SARS-CoV and bat coronaviruses.
References: PMID: 33971664 / doi: 10.1038/s41586-021-03594-0
Contact Info: Kevin Saunders: [email protected]; Barton Haynes: [email protected]
URL: https://www.nature.com/articles/s41586-021-03594-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID; Emory University; BIOQUAL, Inc.; Moderna, Inc.; Johns Hopkins University
Keywords: SARS-CoV-2, virus genomic variants, boost, immune response, primates
Summary of Study: Homologous mRNA-1273 boost can significantly improve both the breadth and potency of neutralizing antibody responses and confer protection against upper and lower airway infection to a heterologous challenge virus, which is relatively resistant to in vitro neutralization.
References: PMID: 34672695 / doi: 10.1126/science.abl8912
Contact Info: Robert Seder: [email protected]; Barney Graham: [email protected]
URL: https://www.science.org/doi/10.1126/science.abl8912?url_ver=Z39.88-2003&rfr_id=…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID; Emory University; BIOQUAL, Inc.; Moderna, Inc.; Johns Hopkins University
Keywords: SARS-CoV-2, virus genomic variants, boost, immune response, primates
Summary of Study: Homologous mRNA-1273 boost can significantly improve both the breadth and potency of neutralizing antibody responses and confer protection against upper and lower airway infection to a heterologous challenge virus, which is relatively resistant to in vitro neutralization.
References: PMID: 34672695 / doi: 10.1126/science.abl8912
Contact Info: Robert Seder: [email protected]; Barney Graham: [email protected]
URL: https://www.science.org/doi/10.1126/science.abl8912?url_ver=Z39.88-2003&rfr_id=…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIH, University of Oxford, NIAID, Icahn School of Medicine at Mount Sinai
Keywords: SARS-CoV-2, adenovirus-based vaccine, intranasal administration, hamsters, primates
Summary of Study: Intranasal vaccination with ChAdOx1 nCoV-19/AZD1222 reduced virus concentrations in nasal swabs in two different SARS-CoV-2 animal models, warranting further investigation as a potential vaccination route for COVID-19 vaccines.
References: PMID: 34315826 / doi: 10.1126/scitranslmed.abh0755
Contact Info: Vincent Munster: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abh0755?url_ver=Z39.88-2003&rf…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIH, University of Oxford, NIAID, Icahn School of Medicine at Mount Sinai
Keywords: SARS-CoV-2, adenovirus-based vaccine, intranasal administration, hamsters, primates
Summary of Study: Intranasal vaccination with ChAdOx1 nCoV-19/AZD1222 reduced virus concentrations in nasal swabs in two different SARS-CoV-2 animal models, warranting further investigation as a potential vaccination route for COVID-19 vaccines.
References: PMID: 34315826 / doi: 10.1126/scitranslmed.abh0755
Contact Info: Vincent Munster: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abh0755?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Johns Hopkins School of Medicine; Yale University School of Medicine
Keywords: SARS-CoV-2, several animal species, immunological response, primates
Summary of Study: This review discusses small and large animal model studies previously used in SARS-CoV-2 research that may be useful in elucidating the immunological contributions to hallmark syndromes observed with COVID-19.
References: PMID: 33914873 / doi: 10.1093/ilar/ilab010
Contact Info: Rebecca Veenhuis: [email protected]
URL: https://academic.oup.com/ilarjournal/advance-article/doi/10.1093/ilar/ilab010/6…
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Johns Hopkins School of Medicine; Yale University School of Medicine
Keywords: SARS-CoV-2, several animal species, immunological response, primates
Summary of Study: This review discusses small and large animal model studies previously used in SARS-CoV-2 research that may be useful in elucidating the immunological contributions to hallmark syndromes observed with COVID-19.
References: PMID: 33914873 / doi: 10.1093/ilar/ilab010
Contact Info: Rebecca Veenhuis: [email protected]
URL: https://academic.oup.com/ilarjournal/advance-article/doi/10.1093/ilar/ilab010/6…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Universite de Paris, Institut Pasteur and others
Keywords: SARS-CoV-2, mathematical model, viral dynamics, immune response, viral clearance, primates
Summary of Study: Results provide estimates of SARS-CoV-2 viral kinetic parameters in an experimental model of mild infection and they provide means to assess the efficacy of future antiviral treatments.
References: PMID: 33730053 / doi: 10.1371/journal.pcbi.1008785
Contact Info: Antonio Goncalves: [email protected]
URL: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008785
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Universite de Paris, Institut Pasteur and others
Keywords: SARS-CoV-2, mathematical model, viral dynamics, immune response, viral clearance, primates
Summary of Study: Results provide estimates of SARS-CoV-2 viral kinetic parameters in an experimental model of mild infection and they provide means to assess the efficacy of future antiviral treatments.
References: PMID: 33730053 / doi: 10.1371/journal.pcbi.1008785
Contact Info: Antonio Goncalves: [email protected]
URL: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008785
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: NCI/NIH
Keywords: SARS-CoV-2, ACE2, type I interferon, pathology, primates
Summary of Study: Type I interferon mediates an important innate immune response against viral infection by directly inhibiting viral replication. It also bridges innate to adaptive immunity for long-term protection against viral reinfections.
References: PMID: 34149696 / doi: 10.3389/fimmu.2021.658428
Contact Info: Yongjun Sui: [email protected]; Jay Berzofsky: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.658428/full
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: NCI/NIH
Keywords: SARS-CoV-2, ACE2, type I interferon, pathology, primates
Summary of Study: Type I interferon mediates an important innate immune response against viral infection by directly inhibiting viral replication. It also bridges innate to adaptive immunity for long-term protection against viral reinfections.
References: PMID: 34149696 / doi: 10.3389/fimmu.2021.658428
Contact Info: Yongjun Sui: [email protected]; Jay Berzofsky: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.658428/full
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Amsterdam; University Paris-Saclay, Inserm, CEA; AIMM Therapeutics BV; J&S Preclinical Solutions; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, variants of concern, third vaccination, mice, rabbits, primates
Summary of Study: A third immunization improves neutralizing antibody titers against the variants-of-concern (Alpha, Beta, Gamma, and Delta).
References: PMID: 34862406 / doi: 10.1038/s41541-021-00411-7
Contact Info: Rogier Sanders: [email protected]
URL: https://www.nature.com/articles/s41541-021-00411-7
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Amsterdam; University Paris-Saclay, Inserm, CEA; AIMM Therapeutics BV; J&S Preclinical Solutions; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, variants of concern, third vaccination, mice, rabbits, primates
Summary of Study: A third immunization improves neutralizing antibody titers against the variants-of-concern (Alpha, Beta, Gamma, and Delta).
References: PMID: 34862406 / doi: 10.1038/s41541-021-00411-7
Contact Info: Rogier Sanders: [email protected]
URL: https://www.nature.com/articles/s41541-021-00411-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets, howler monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Instituto Federal do Norte de Minas Gerais, Brazil; Universidade Federal dos Vales do Jequitinhonha e Mucuri, Brazil; Centro Estadual de Vigilancia em Saude; Universidade de Brasilia; Universidade Federal de Minas Gerais; State University of Santa Cruz; Universidade Federal de Tocantins
Keywords: SARS-CoV-2, wild animals, RT-qPCR, primates
Summary of Study: 51 NHPs were examined for signs of SARS-CoV-2; 89 samples of various tissues were analyzed, with no SARS-CoV-2 positive samples detected, regardless of NHP species, tissue, habitat, municipalities or state/biome tested.
References: PMID: 34843021 / doi: 10.1007/s10393-021-01569-1
Contact Info: Danilo Bretas de Oliveira: [email protected]
URL: https://link.springer.com/article/10.1007%2Fs10393-021-01569-1
NHP Species: marmosets, howler monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Instituto Federal do Norte de Minas Gerais, Brazil; Universidade Federal dos Vales do Jequitinhonha e Mucuri, Brazil; Centro Estadual de Vigilancia em Saude; Universidade de Brasilia; Universidade Federal de Minas Gerais; State University of Santa Cruz; Universidade Federal de Tocantins
Keywords: SARS-CoV-2, wild animals, RT-qPCR, primates
Summary of Study: 51 NHPs were examined for signs of SARS-CoV-2; 89 samples of various tissues were analyzed, with no SARS-CoV-2 positive samples detected, regardless of NHP species, tissue, habitat, municipalities or state/biome tested.
References: PMID: 34843021 / doi: 10.1007/s10393-021-01569-1
Contact Info: Danilo Bretas de Oliveira: [email protected]
URL: https://link.springer.com/article/10.1007%2Fs10393-021-01569-1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: California National Primate Research Center, UC Davis School of Medicine, The Rockefeller University, UC Davis School of Veterinary Medicine, DMID/NIAID/NIH, Howard Hughes Medical Institute
Keywords: SARS-CoV-2, therapeutic interventions, neutralizing monoclonal antibodies, pathology, primates
Summary of Study: Study provides proof-of-concept in support of further clinical development of monoclonal antibodies C135-LS and C144-LS against COVID-19 during early infection.
References: PMID: 34228761 / doi: 10.1371/journal.ppat.1009688
Contact Info: Koen Van Rompay: [email protected]; Michel Nussenzweig: [email protected]; J. Rachel Reader: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009688
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: California National Primate Research Center, UC Davis School of Medicine, The Rockefeller University, UC Davis School of Veterinary Medicine, DMID/NIAID/NIH, Howard Hughes Medical Institute
Keywords: SARS-CoV-2, therapeutic interventions, neutralizing monoclonal antibodies, pathology, primates
Summary of Study: Study provides proof-of-concept in support of further clinical development of monoclonal antibodies C135-LS and C144-LS against COVID-19 during early infection.
References: PMID: 34228761 / doi: 10.1371/journal.ppat.1009688
Contact Info: Koen Van Rompay: [email protected]; Michel Nussenzweig: [email protected]; J. Rachel Reader: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009688
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Agricultural Sciences; National Research Center for Exotic Animal Diseases, China Animal Health and Epidemiology Center
Keywords: SARS-CoV-2, meta analysis, review of the animal models, vaccination, mice, hamsters, ferrets, primates
Summary of Study: This review summarizes the landscape of animal models for COVID-19 vaccine evaluation and advanced vaccines with an efficacy range from about 50% to more than 95%.
References: PMID: 34696190 / doi: 10.3390/vaccines9101082
Contact Info: Yuwei Gao: [email protected]; Feihu Yan: [email protected]; Songtao Yang: [email protected]
URL: https://www.mdpi.com/2076-393X/9/10/1082
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Agricultural Sciences; National Research Center for Exotic Animal Diseases, China Animal Health and Epidemiology Center
Keywords: SARS-CoV-2, meta analysis, review of the animal models, vaccination, mice, hamsters, ferrets, primates
Summary of Study: This review summarizes the landscape of animal models for COVID-19 vaccine evaluation and advanced vaccines with an efficacy range from about 50% to more than 95%.
References: PMID: 34696190 / doi: 10.3390/vaccines9101082
Contact Info: Yuwei Gao: [email protected]; Feihu Yan: [email protected]; Songtao Yang: [email protected]
URL: https://www.mdpi.com/2076-393X/9/10/1082
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Institute of Advanced Study in Science and Technology (India), Biodiversity Research Center, Academic Sinica (Taipei) and others
Keywords: SARS-CoV-2, ACE2 variants, binding affinity of ACE2 to S-protein, multiple species, humans and primates
Summary of Study: Binding affinity of ACE2 to S-protein was studied in various NHP species. Based on findings, the authors propose that the common ancestor of primates was strongly resistant to and that of New World monkeys was completely resistant to SARS-CoV-2; whereas apes and Old World monkeys, like most humans, are susceptible. This study increases our understanding of the differences in susceptibility to SARS-CV-2 infection among primates.
References: PMID: 33674876 / doi: 10.1093/molbev/msab060
Contact Info: Yan Yuan Tseng: [email protected]; Lily Hui-Ching Wang: [email protected]
URL: https://academic.oup.com/mbe/advance-article/doi/10.1093/molbev/msab060/6154855
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Institute of Advanced Study in Science and Technology (India), Biodiversity Research Center, Academic Sinica (Taipei) and others
Keywords: SARS-CoV-2, ACE2 variants, binding affinity of ACE2 to S-protein, multiple species, humans and primates
Summary of Study: Binding affinity of ACE2 to S-protein was studied in various NHP species. Based on findings, the authors propose that the common ancestor of primates was strongly resistant to and that of New World monkeys was completely resistant to SARS-CoV-2; whereas apes and Old World monkeys, like most humans, are susceptible. This study increases our understanding of the differences in susceptibility to SARS-CV-2 infection among primates.
References: PMID: 33674876 / doi: 10.1093/molbev/msab060
Contact Info: Yan Yuan Tseng: [email protected]; Lily Hui-Ching Wang: [email protected]
URL: https://academic.oup.com/mbe/advance-article/doi/10.1093/molbev/msab060/6154855
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Beijing Institute of Microbiology & Immunology; Institute of Military Veterinary, Academic of Military Medical Sciences
Keywords: SARS-CoV-2, recombinant vaccine, efficacy of RBD-Fc Vacc, mice and primates
Summary of Study: A new recombinant vaccine made by fusing the SARS-CoV-2 RBD with the Fc fragment of human IgG1induced a potent immune response, protecting cynomolgus macaques against SARS-CoV-2 infection.
References: PMID: 33731916 / doi: 10.1038/s41423-021-00658-z
Contact Info: Yansong Sun: [email protected]; Yuwei Gao: [email protected]
URL: https://www.nature.com/articles/s41423-021-00658-z
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Beijing Institute of Microbiology & Immunology; Institute of Military Veterinary, Academic of Military Medical Sciences
Keywords: SARS-CoV-2, recombinant vaccine, efficacy of RBD-Fc Vacc, mice and primates
Summary of Study: A new recombinant vaccine made by fusing the SARS-CoV-2 RBD with the Fc fragment of human IgG1induced a potent immune response, protecting cynomolgus macaques against SARS-CoV-2 infection.
References: PMID: 33731916 / doi: 10.1038/s41423-021-00658-z
Contact Info: Yansong Sun: [email protected]; Yuwei Gao: [email protected]
URL: https://www.nature.com/articles/s41423-021-00658-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Yerkes National Primate Research Center, Duke University School of Medicine, Harvard
Keywords: SARS-CoV-2, modified vaccinia Ankara vector-based vaccine, immune response, pathology, primates
Summary of Study: MVA/S vaccination can provide protection from intranasal and intratracheal SARS-CoV-2 challenge and support further development of this vaccine to test immunogenicity and efficacy in humans.
References: PMID: 33631118 / doi: 10.1016/j.immuni.2021.02.001
Contact Info: Rama Rao Amara: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S107476132100042X?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Yerkes National Primate Research Center, Duke University School of Medicine, Harvard
Keywords: SARS-CoV-2, modified vaccinia Ankara vector-based vaccine, immune response, pathology, primates
Summary of Study: MVA/S vaccination can provide protection from intranasal and intratracheal SARS-CoV-2 challenge and support further development of this vaccine to test immunogenicity and efficacy in humans.
References: PMID: 33631118 / doi: 10.1016/j.immuni.2021.02.001
Contact Info: Rama Rao Amara: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S107476132100042X?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Institute of Medical Biology, Chinese Academy of Medical Sciences & U. Mass.
Keywords: SARS-CoV-2, DNA and protein vaccine combination, primates
Summary of Study: The novel combination of a DNA vaccine encoding the full-length Spike (S) protein of SARS-CoV-2 and a recombinant S1 protein vaccine elicited full protection against the challenge of SARS-CoV-2 in an NHP model.
References: PMID: 33555988 / doi: 10.1080/22221751.2021.1887767
Contact Info: Wei Cun: [email protected] / Shan Lu: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1887767
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Institute of Medical Biology, Chinese Academy of Medical Sciences & U. Mass.
Keywords: SARS-CoV-2, DNA and protein vaccine combination, primates
Summary of Study: The novel combination of a DNA vaccine encoding the full-length Spike (S) protein of SARS-CoV-2 and a recombinant S1 protein vaccine elicited full protection against the challenge of SARS-CoV-2 in an NHP model.
References: PMID: 33555988 / doi: 10.1080/22221751.2021.1887767
Contact Info: Wei Cun: [email protected] / Shan Lu: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1887767
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Indian Council of Medical Research-National Institute of Virology
Keywords: SARS-CoV-2, inactivated SARS-CoV-2 vaccine candidate, immunogenicity, efficacy, primates
Summary of Study: A two-dose regimen of vaccine candidate BBV152 with adjuvant B induces a significant immune response and provides effective protection in rhesus macaques challenged with SARS-CoV-2.
References: PMID: 33654090 / doi: 10.1038/s41467-021-21639-w
Contact Info: Balram Bhargava: [email protected]
URL: https://www.nature.com/articles/s41467-021-21639-w
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Indian Council of Medical Research-National Institute of Virology
Keywords: SARS-CoV-2, inactivated SARS-CoV-2 vaccine candidate, immunogenicity, efficacy, primates
Summary of Study: A two-dose regimen of vaccine candidate BBV152 with adjuvant B induces a significant immune response and provides effective protection in rhesus macaques challenged with SARS-CoV-2.
References: PMID: 33654090 / doi: 10.1038/s41467-021-21639-w
Contact Info: Balram Bhargava: [email protected]
URL: https://www.nature.com/articles/s41467-021-21639-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Texas Medical Branch, Pfizer
Keywords: SARS-CoV-2, vaccine-elicited immunity, virus variant, primates
Summary of Study: The D614G mutation modestly reduced SARS-CoV-2 neutralization by BNT162b2 vaccine-elicited mouse, rhesus, and human sera, concurring with the 95% vaccine efficacy observed in clinical trial.
References: PMID: 33767200 / doi: 10.1038/s41541-021-00313-8
Contact Info: Philip Dormitzer: philip,[email protected]
URL: https://www.nature.com/articles/s41541-021-00313-8
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Texas Medical Branch, Pfizer
Keywords: SARS-CoV-2, vaccine-elicited immunity, virus variant, primates
Summary of Study: The D614G mutation modestly reduced SARS-CoV-2 neutralization by BNT162b2 vaccine-elicited mouse, rhesus, and human sera, concurring with the 95% vaccine efficacy observed in clinical trial.
References: PMID: 33767200 / doi: 10.1038/s41541-021-00313-8
Contact Info: Philip Dormitzer: philip,[email protected]
URL: https://www.nature.com/articles/s41541-021-00313-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Capital Medical University, Beijing, China; Baruch S. Blumberg Institute
Keywords: SARS-CoV-2, animal ACE2, receptor, entry, furin cleavage, animal hosts
Summary of Study: Receptor activity of ACE2 was examined in 14 mammal species, including the rhesus macaque. Rhesus exhibited the highest ACE2 receptor activity.
References: doi: 10.1101/2020.04.19.048710; Preprint
Contact Info: Zhao X, et al.; correspondence to Xuesen Zhao ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32661139/
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Capital Medical University, Beijing, China; Baruch S. Blumberg Institute
Keywords: SARS-CoV-2, animal ACE2, receptor, entry, furin cleavage, animal hosts
Summary of Study: Receptor activity of ACE2 was examined in 14 mammal species, including the rhesus macaque. Rhesus exhibited the highest ACE2 receptor activity.
References: doi: 10.1101/2020.04.19.048710; Preprint
Contact Info: Zhao X, et al.; correspondence to Xuesen Zhao ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32661139/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Harvard, Massachusetts Institute of Technology, and more
Keywords: scRNA-seq, interferon, ISG, ACE2, SARS-CoV-2, COVID-19, influenza, non-human primate, human, mouse
Summary of Study: The authors analyzed human, macaque, and mouse scRNA-seq data sets across health and disease to uncover putative targets of SARS-CoV-2 among tissue-resident cell subsets. Data suggest that SARS-CoV-2 could exploit species-specific interferon-driven upregulation of ACE2, a tissue-protective mediator during lung injury, to enhance infection.
References: doi: 10.1016/j.cell.2020.04.035; PMID: 32413319
Contact Info: Ziegler CGK, et al.; correspondence to Jose Ordovas-Montanes ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32413319/
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Harvard, Massachusetts Institute of Technology, and more
Keywords: scRNA-seq, interferon, ISG, ACE2, SARS-CoV-2, COVID-19, influenza, non-human primate, human, mouse
Summary of Study: The authors analyzed human, macaque, and mouse scRNA-seq data sets across health and disease to uncover putative targets of SARS-CoV-2 among tissue-resident cell subsets. Data suggest that SARS-CoV-2 could exploit species-specific interferon-driven upregulation of ACE2, a tissue-protective mediator during lung injury, to enhance infection.
References: doi: 10.1016/j.cell.2020.04.035; PMID: 32413319
Contact Info: Ziegler CGK, et al.; correspondence to Jose Ordovas-Montanes ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32413319/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Peking Union Medical College, Yunnan, China
Keywords: SARS-CoV-2, Gastrointestinal Tract, primates
Summary of Study: Both intranasal and intragastric inoculation with SARS-CoV-2 caused pneumonia and GI dysfunction in the rhesus macaque model. Inflammatory cytokines are possible connections for the pathogenesis of SARS-CoV-2 between the respiratory and digestive systems.
References: PMID: 33307034/doi: 10.1053/j.gastro.2020.12.001
Contact Info: Xiaozhong Peng: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S001650852035527X?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Peking Union Medical College, Yunnan, China
Keywords: SARS-CoV-2, Gastrointestinal Tract, primates
Summary of Study: Both intranasal and intragastric inoculation with SARS-CoV-2 caused pneumonia and GI dysfunction in the rhesus macaque model. Inflammatory cytokines are possible connections for the pathogenesis of SARS-CoV-2 between the respiratory and digestive systems.
References: PMID: 33307034/doi: 10.1053/j.gastro.2020.12.001
Contact Info: Xiaozhong Peng: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S001650852035527X?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: SoLongevity Research, Milan, Italy
Keywords: SARS-CoV-1 and SARS-CoV-2, cross-reactive immunity, pathogenesis, primates
Summary of Study: Review Article discussing the potential of cross-reactive immunity to drive the immunopathogenesis of COVID-19 and its implications for current efforts to develop immune-based therapies and vaccines.
References: PMID: 33178193/doi: 10.3389/fimmu.2020.567710
Contact Info: Alberto Beretta: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2020.567710/full
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: SoLongevity Research, Milan, Italy
Keywords: SARS-CoV-1 and SARS-CoV-2, cross-reactive immunity, pathogenesis, primates
Summary of Study: Review Article discussing the potential of cross-reactive immunity to drive the immunopathogenesis of COVID-19 and its implications for current efforts to develop immune-based therapies and vaccines.
References: PMID: 33178193/doi: 10.3389/fimmu.2020.567710
Contact Info: Alberto Beretta: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2020.567710/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Chinese Ministry of Health
Keywords: coronavirus, SARS-CoV-2, viral transmission, nonhuman primate
Summary of Study: Rhesus macaques were inoculated with SARS-CoV-2/WH-09/human/2020/CHN via conjunctival, intratracheal, and intragastric routes. Results suggest that conjunctiva is a potential portal for viral transmission; virus was also detected after IT inoculation. No virus was detected after IG inoculation.
References: doi: 10.1101/2020.03.13.990036; Preprint
Contact Info: Deng W, et al.; correspondence to Chuan Qin ([email protected])
URL: https://www.biorxiv.org/content/10.1101/2020.03.13.990036v2.full
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Chinese Ministry of Health
Keywords: coronavirus, SARS-CoV-2, viral transmission, nonhuman primate
Summary of Study: Rhesus macaques were inoculated with SARS-CoV-2/WH-09/human/2020/CHN via conjunctival, intratracheal, and intragastric routes. Results suggest that conjunctiva is a potential portal for viral transmission; virus was also detected after IT inoculation. No virus was detected after IG inoculation.
References: doi: 10.1101/2020.03.13.990036; Preprint
Contact Info: Deng W, et al.; correspondence to Chuan Qin ([email protected])
URL: https://www.biorxiv.org/content/10.1101/2020.03.13.990036v2.full
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: NIAID
Keywords: MERS-CoV, animal model, antiviral, remdesivir, therapy.
Summary of Study: The efficacy of prophylactic and therapeutic remdesivir treatment was tested in a rhesus macaque model of MERS-CoV infection. Prophylactic remdesivir treatment completely prevented MERS-CoV-induced clinical disease; therapeutic remdesivir treatment also provided a clear clinical benefit. The data support testing the efficacy of remdesivir treatment in the context of a MERS clinical trial.
References: doi: 10.1073/pnas.1922083117; PMID: 32054787
Contact Info: de Wit E, et al.; Correspondence to Emmie de Wit ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32054787/
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: NIAID
Keywords: MERS-CoV, animal model, antiviral, remdesivir, therapy.
Summary of Study: The efficacy of prophylactic and therapeutic remdesivir treatment was tested in a rhesus macaque model of MERS-CoV infection. Prophylactic remdesivir treatment completely prevented MERS-CoV-induced clinical disease; therapeutic remdesivir treatment also provided a clear clinical benefit. The data support testing the efficacy of remdesivir treatment in the context of a MERS clinical trial.
References: doi: 10.1073/pnas.1922083117; PMID: 32054787
Contact Info: de Wit E, et al.; Correspondence to Emmie de Wit ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32054787/
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2020
Study Type/Review:
NPRC/Institute: University of Minnesota
Keywords: 2019-nCoV, SARS coronavirus, ACE2, animal reservoir, cross-species transmission, human-to-human transmission
Summary of Study: The authors' decade-long structural studies on the receptor recognition by SARS-CoV have identified key interactions between SARS-CoV spike protein and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of SARS-CoV.
References: doi: 10.1128/JVI.00127-20
Contact Info: Wan Y, et al.; correspondence to Fang Li ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/31996437/
NHP Species: multiple species
Year Published: 2020
Study Type/Review:
NPRC/Institute: University of Minnesota
Keywords: 2019-nCoV, SARS coronavirus, ACE2, animal reservoir, cross-species transmission, human-to-human transmission
Summary of Study: The authors' decade-long structural studies on the receptor recognition by SARS-CoV have identified key interactions between SARS-CoV spike protein and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of SARS-CoV.
References: doi: 10.1128/JVI.00127-20
Contact Info: Wan Y, et al.; correspondence to Fang Li ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/31996437/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: NIAID
Keywords: coronavirus, SARS-CoV-2, animal models, viral load, nonhuman primate
Summary of Study: Rhesus macaques were inoculated with SARS-CoV-2 (isolate nCoV WA1-2020). Data established that the rhesus macaque recapitulates human disease with respect to virus replication and shedding, the presence of pulmonary infiltrates, histological lesions and seroconversion.
References: doi: 10.1038/s41586-020-2324-7; PMID: 32396922
Contact Info: Munster VJ, et al.; correspondence to Emmie de Wit ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32396922/
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: NIAID
Keywords: coronavirus, SARS-CoV-2, animal models, viral load, nonhuman primate
Summary of Study: Rhesus macaques were inoculated with SARS-CoV-2 (isolate nCoV WA1-2020). Data established that the rhesus macaque recapitulates human disease with respect to virus replication and shedding, the presence of pulmonary infiltrates, histological lesions and seroconversion.
References: doi: 10.1038/s41586-020-2324-7; PMID: 32396922
Contact Info: Munster VJ, et al.; correspondence to Emmie de Wit ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32396922/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences and Comparative Medicine Center
Keywords: pathogenicity, pneumonia, rhesus macaque model, SARS-CoV-2
Summary of Study: SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys. Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection.
References: doi: 10.1002/ame2.12108
Contact Info: Yu P, et al.; correspondence to Chuan Qin ([email protected]) and Wenjie Tan ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32318665/
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences and Comparative Medicine Center
Keywords: pathogenicity, pneumonia, rhesus macaque model, SARS-CoV-2
Summary of Study: SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys. Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection.
References: doi: 10.1002/ame2.12108
Contact Info: Yu P, et al.; correspondence to Chuan Qin ([email protected]) and Wenjie Tan ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32318665/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: National Institute of Biologicals, Noida, India
Keywords: SARS-CoV-2, many species, review
Summary of Study: This review article finds the rhesus macaque most closely resembles the SARS-CoV-2 infection observed in humans.
References: PMID: 33283030/doi: 10.1007/s13337-020-00637-4
Contact Info: Suresh Kumar: [email protected]
URL: https://link.springer.com/article/10.1007/s13337-020-00637-4
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: National Institute of Biologicals, Noida, India
Keywords: SARS-CoV-2, many species, review
Summary of Study: This review article finds the rhesus macaque most closely resembles the SARS-CoV-2 infection observed in humans.
References: PMID: 33283030/doi: 10.1007/s13337-020-00637-4
Contact Info: Suresh Kumar: [email protected]
URL: https://link.springer.com/article/10.1007/s13337-020-00637-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: University of Washington, Washington National Primate Research Center
Keywords: coronavirus, SARS-CoV-2, vaccine, RNA, replicon, nanoparticle, nonhuman primate
Summary of Study: Single-dose intramuscular vaccination with LION/repRNA-CoV2S elicited antibody responses that potently neutralized SARS-CoV-2 in pigtail macaques.
References: doi: 10.1101/2020.05.28.121640; Preprint
Contact Info: Erasmus JH, et al.; correspondence to Deborah Fuller ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32511417/
NHP Species: pigtail macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: University of Washington, Washington National Primate Research Center
Keywords: coronavirus, SARS-CoV-2, vaccine, RNA, replicon, nanoparticle, nonhuman primate
Summary of Study: Single-dose intramuscular vaccination with LION/repRNA-CoV2S elicited antibody responses that potently neutralized SARS-CoV-2 in pigtail macaques.
References: doi: 10.1101/2020.05.28.121640; Preprint
Contact Info: Erasmus JH, et al.; correspondence to Deborah Fuller ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32511417/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Institute of Human Virology, Guangdong, China
Keywords: SARS-CoV-2, nanoparticle vaccine, primates
Summary of Study: Nanoparticle vaccines (developed by covalently conjugating the self-assembled 24-mer ferritin to the receptor binding domain (RBD) and/or heptad repeat (HR) subunits of the SARS-CoV-2 spike protein) induced neutralizing antibodies, and T and B cell responses prior to boost immunization in rhesus macaques.
References: PMID: 33275896/doi: 10.1016/j.immuni.2020.11.015
Contact Info: Hui Zhang: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1074761320305021?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Institute of Human Virology, Guangdong, China
Keywords: SARS-CoV-2, nanoparticle vaccine, primates
Summary of Study: Nanoparticle vaccines (developed by covalently conjugating the self-assembled 24-mer ferritin to the receptor binding domain (RBD) and/or heptad repeat (HR) subunits of the SARS-CoV-2 spike protein) induced neutralizing antibodies, and T and B cell responses prior to boost immunization in rhesus macaques.
References: PMID: 33275896/doi: 10.1016/j.immuni.2020.11.015
Contact Info: Hui Zhang: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1074761320305021?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Karolinska Institutet, Stockholm
Keywords: SARS-CoV-2, spike trimers, neutralizing antibodies, mice, primates
Summary of Study: Adjuvanted protein intramuscular immunization with SARS-CoV-2 spike trimers, stabilized in prefusion conformation, results in potent antibody responses in mice and rhesus macaque.
References: doi:10.1101/2020.07.31.228486
Contact Info: Mandolesi, Marco; [email protected], [email protected], [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.07.31.228486v1
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Karolinska Institutet, Stockholm
Keywords: SARS-CoV-2, spike trimers, neutralizing antibodies, mice, primates
Summary of Study: Adjuvanted protein intramuscular immunization with SARS-CoV-2 spike trimers, stabilized in prefusion conformation, results in potent antibody responses in mice and rhesus macaque.
References: doi:10.1101/2020.07.31.228486
Contact Info: Mandolesi, Marco; [email protected], [email protected], [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.07.31.228486v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: NIAID
Keywords: coronavirus, SARS-CoV-2, MERS-CoV, vaccine
Summary of Study: Rhesus macaques vaccinated intramuscularly with ChAdOx1 nCoV-19 showed humoral and cellular immune response. The authors observed a significantly reduced viral load in bronchoalveolar lavage fluid and respiratory tract tissues of vaccinated animals challenged with SARS-CoV-2 compared with control animals, and no pneumonia was observed in the vaccinated animals.
References: doi: 10.1101/2020.05.13.093195; Preprint; PMID: 32511340
Contact Info: van Doremalen N, et al.; correspondence to Vincent Munster ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32511340/
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: NIAID
Keywords: coronavirus, SARS-CoV-2, MERS-CoV, vaccine
Summary of Study: Rhesus macaques vaccinated intramuscularly with ChAdOx1 nCoV-19 showed humoral and cellular immune response. The authors observed a significantly reduced viral load in bronchoalveolar lavage fluid and respiratory tract tissues of vaccinated animals challenged with SARS-CoV-2 compared with control animals, and no pneumonia was observed in the vaccinated animals.
References: doi: 10.1101/2020.05.13.093195; Preprint; PMID: 32511340
Contact Info: van Doremalen N, et al.; correspondence to Vincent Munster ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32511340/
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2020
Study Type/Review:
NPRC/Institute: Tongji Medical College, Wuhan, China
Keywords: SARS, ACE2, receptor-binding domain, pneumonia
Summary of Study: The authors analyzed 82 representative ACE2 sequences from the 1000 sequences with the closest homology to the human ACE2 protein to identify potential SARS-CoV-2 natural and intermediate hosts, as well as susceptible animals. Results suggest that several NHPs may be intermediate hosts and most are susceptible to SARS-CoV-2.
References: doi: 10.26434/chemrxiv.12057996.v1; Preprint
Contact Info: Wu C, et al.; correspondence to Hui Li ([email protected])
URL: https://europepmc.org/article/ppr/ppr138914
NHP Species: multiple species
Year Published: 2020
Study Type/Review:
NPRC/Institute: Tongji Medical College, Wuhan, China
Keywords: SARS, ACE2, receptor-binding domain, pneumonia
Summary of Study: The authors analyzed 82 representative ACE2 sequences from the 1000 sequences with the closest homology to the human ACE2 protein to identify potential SARS-CoV-2 natural and intermediate hosts, as well as susceptible animals. Results suggest that several NHPs may be intermediate hosts and most are susceptible to SARS-CoV-2.
References: doi: 10.26434/chemrxiv.12057996.v1; Preprint
Contact Info: Wu C, et al.; correspondence to Hui Li ([email protected])
URL: https://europepmc.org/article/ppr/ppr138914
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2020
Study Type/Review:
NPRC/Institute: Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China
Keywords: coronavirus, SARS-CoV-2, ACE2
Summary of Study: Authors conducted sequence and structural analyses of angiotensin-converting enzyme 2 (ACE2) from different species, which sheds some light on cross-species receptor usage of 2019-nCoV.
References: doi: 10.1016/j.jinf.2020.02.013
Contact Info: Li R, et al.; correspondence to Gaiping Zhang ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32092392/
NHP Species: multiple species
Year Published: 2020
Study Type/Review:
NPRC/Institute: Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China
Keywords: coronavirus, SARS-CoV-2, ACE2
Summary of Study: Authors conducted sequence and structural analyses of angiotensin-converting enzyme 2 (ACE2) from different species, which sheds some light on cross-species receptor usage of 2019-nCoV.
References: doi: 10.1016/j.jinf.2020.02.013
Contact Info: Li R, et al.; correspondence to Gaiping Zhang ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32092392/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Department of Molecular Microbiology and Immunology, Saint Louis University
Keywords: SARS-CoV-2, focus forming assay, viral growth kinetics
Summary of Study: Characterization of cells susceptible to SARS-COV-2 and methods for detection of neutralizing antibody by focus forming assay
References: doi: 10.1101/2020.08.20.259838
Contact Info: E. Taylor Stone et al; Amelia K. Pinto, [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.08.20.259838v1
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Department of Molecular Microbiology and Immunology, Saint Louis University
Keywords: SARS-CoV-2, focus forming assay, viral growth kinetics
Summary of Study: Characterization of cells susceptible to SARS-COV-2 and methods for detection of neutralizing antibody by focus forming assay
References: doi: 10.1101/2020.08.20.259838
Contact Info: E. Taylor Stone et al; Amelia K. Pinto, [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.08.20.259838v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2020
Study Type/Review:
NPRC/Institute: BGi (China) and others
Keywords: single-cell transcriptomics, nonhuman primate, COVID-19, SARS-CoV-2, ACE2, TMPRSS2, kidney, interleukin 6, STAT transcription factors, immune cell exhaustion
Summary of Study: A single-cell transcriptome atlas of nine monkey tissues was used to study COVID-19. ACE2+TMPRSS2+ epithelial cells of lung, kidney and liver were shown to be targets for SARS-CoV-2. ACE2 correlation analysis identifies IDO2 and ANPEP as potential therapeutic opportunities.
References: doi: 10.1101/2020.04.10.022103; Preprint
Contact Info: Han L, et al.; correspondence to Xun Xu ([email protected])
URL: https://www.biorxiv.org/content/10.1101/2020.04.10.022103v2.abstract
NHP Species:
Year Published: 2020
Study Type/Review:
NPRC/Institute: BGi (China) and others
Keywords: single-cell transcriptomics, nonhuman primate, COVID-19, SARS-CoV-2, ACE2, TMPRSS2, kidney, interleukin 6, STAT transcription factors, immune cell exhaustion
Summary of Study: A single-cell transcriptome atlas of nine monkey tissues was used to study COVID-19. ACE2+TMPRSS2+ epithelial cells of lung, kidney and liver were shown to be targets for SARS-CoV-2. ACE2 correlation analysis identifies IDO2 and ANPEP as potential therapeutic opportunities.
References: doi: 10.1101/2020.04.10.022103; Preprint
Contact Info: Han L, et al.; correspondence to Xun Xu ([email protected])
URL: https://www.biorxiv.org/content/10.1101/2020.04.10.022103v2.abstract
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: SWNPRC/Regeneron
Keywords: SARS-CoV-2, neutralizing antibody therapy, primates
Summary of Study: REGN-COV2, a cocktail of two potent neutralizing antibodies (REGN10987+REGN10922) can greatly reduce virus load in lower and upper airway and decrease virus induced pathological sequelae when administered prophylactically or therapeutically.
References: doi: 10.1101/2020.08.02.233320
Contact Info: Baum, A., et al; correspondence to C.A. Kyratsous, [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.08.02.233320v1
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: SWNPRC/Regeneron
Keywords: SARS-CoV-2, neutralizing antibody therapy, primates
Summary of Study: REGN-COV2, a cocktail of two potent neutralizing antibodies (REGN10987+REGN10922) can greatly reduce virus load in lower and upper airway and decrease virus induced pathological sequelae when administered prophylactically or therapeutically.
References: doi: 10.1101/2020.08.02.233320
Contact Info: Baum, A., et al; correspondence to C.A. Kyratsous, [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.08.02.233320v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: crab-eating macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: NIAID
Keywords: SARS-CoV-2, serial computed tomography, positron emission tomography, FDG
Summary of Study: Crab-eating macaques were exposed to SARS-CoV-2 via direct bilateral primary intrabronchial instillation, which resulted in mild-moderate COVID-19 symptoms.
References: doi: 10.1101/2020.05.14.096727; PMID: 32511338
Contact Info: Finch CL, et al.; correspondence to Thomas Friedrich ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32511338/
NHP Species: crab-eating macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: NIAID
Keywords: SARS-CoV-2, serial computed tomography, positron emission tomography, FDG
Summary of Study: Crab-eating macaques were exposed to SARS-CoV-2 via direct bilateral primary intrabronchial instillation, which resulted in mild-moderate COVID-19 symptoms.
References: doi: 10.1101/2020.05.14.096727; PMID: 32511338
Contact Info: Finch CL, et al.; correspondence to Thomas Friedrich ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32511338/
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2020
Study Type/Review:
NPRC/Institute: Jiaotong Univ. Health Science Center, Xi'an, Shaanxi, China
Keywords: SARS-CoV-2, phylogeny and expression pattern of ACE2; variety of animals, including primates
Summary of Study: Using bioinformatics tools to screen for the presence of angiotensin converting enzyme 2 (ACE2) in a variety of tissues in various animals, the authors found that the tissue presence of this enzyme marks the tissues vulnerable to SARS-CoV-2 infection. The pattern of infection in cynomolgus macaques was similar to that in humans.
References: PMID: 33364494/doi: 10.1016/j.heliyon.2020.e05725
Contact Info: Enqi Liu: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2405844020325688?via%3Dihub
NHP Species:
Year Published: 2020
Study Type/Review:
NPRC/Institute: Jiaotong Univ. Health Science Center, Xi'an, Shaanxi, China
Keywords: SARS-CoV-2, phylogeny and expression pattern of ACE2; variety of animals, including primates
Summary of Study: Using bioinformatics tools to screen for the presence of angiotensin converting enzyme 2 (ACE2) in a variety of tissues in various animals, the authors found that the tissue presence of this enzyme marks the tissues vulnerable to SARS-CoV-2 infection. The pattern of infection in cynomolgus macaques was similar to that in humans.
References: PMID: 33364494/doi: 10.1016/j.heliyon.2020.e05725
Contact Info: Enqi Liu: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2405844020325688?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: National Infection Service, Public Health England (PHE)
Keywords: SARS-CoV-2, virus replication, lung histopathology, primates
Summary of Study: SARS-CoV-2 replicates in the upper and lower respiratory tract and causes pulmonary lesions in both rhesus and cynomolgus macaques, resembling the mild clinical cases of COVID-19 in humans.
References: doi:10.1101/2020.09.17.301093
Contact Info: Francisco J. Salguero et al; Miles W. Carroll, [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.09.17.301093v1
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: National Infection Service, Public Health England (PHE)
Keywords: SARS-CoV-2, virus replication, lung histopathology, primates
Summary of Study: SARS-CoV-2 replicates in the upper and lower respiratory tract and causes pulmonary lesions in both rhesus and cynomolgus macaques, resembling the mild clinical cases of COVID-19 in humans.
References: doi:10.1101/2020.09.17.301093
Contact Info: Francisco J. Salguero et al; Miles W. Carroll, [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.09.17.301093v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Institute of Basic Medical Sciences, Beijing, China
Keywords: SARS-CoV-2, pathogenesis, aryl hydrocarbon receptor (AhR) signaling, mucus, primates
Summary of Study: Findings potentially explain the silent hypoxia formation in COVID-19 patients, and suggest a possible intervention strategy by targeting the aryl hydrocarbon receptor pathway.
References: PMID: 33159154/doi: 10.1038/s41422-020-00435-z
Contact Info: Bo Huang: [email protected]
URL: https://www.nature.com/articles/s41422-020-00435-z
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Institute of Basic Medical Sciences, Beijing, China
Keywords: SARS-CoV-2, pathogenesis, aryl hydrocarbon receptor (AhR) signaling, mucus, primates
Summary of Study: Findings potentially explain the silent hypoxia formation in COVID-19 patients, and suggest a possible intervention strategy by targeting the aryl hydrocarbon receptor pathway.
References: PMID: 33159154/doi: 10.1038/s41422-020-00435-z
Contact Info: Bo Huang: [email protected]
URL: https://www.nature.com/articles/s41422-020-00435-z