Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Texas Medical Branch, Pfizer
Keywords: SARS-CoV-2, vaccine-elicited immunity, virus variant, primates
Summary of Study: The D614G mutation modestly reduced SARS-CoV-2 neutralization by BNT162b2 vaccine-elicited mouse, rhesus, and human sera, concurring with the 95% vaccine efficacy observed in clinical trial.
References: PMID: 33767200 / doi: 10.1038/s41541-021-00313-8
Contact Info: Philip Dormitzer: philip,[email protected]
URL: https://www.nature.com/articles/s41541-021-00313-8
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Texas Medical Branch, Pfizer
Keywords: SARS-CoV-2, vaccine-elicited immunity, virus variant, primates
Summary of Study: The D614G mutation modestly reduced SARS-CoV-2 neutralization by BNT162b2 vaccine-elicited mouse, rhesus, and human sera, concurring with the 95% vaccine efficacy observed in clinical trial.
References: PMID: 33767200 / doi: 10.1038/s41541-021-00313-8
Contact Info: Philip Dormitzer: philip,[email protected]
URL: https://www.nature.com/articles/s41541-021-00313-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: National Health Commission of the People's Republic of China; Chinese Academy of Sciences; Nanjing Medical University; Beijing Institute of Microbiology and Epidemiology; Jiangsu Rec-biotechnology Col Ltd.
Keywords: SARS-CoV-2, neutralizing antibodies, immunization, spike protein, immunogenicity, rabbits, primates
Summary of Study: The immunogenic data derived from immunization with a combination of SARS-CoV-2 RBD and NTD demonstrate the feasibility of eliciting robust targeted immune profiles by using antibody-guided vaccine design.
References: PMID: 34676098 / doi: 10.1093/nsr/nwab053
Contact Info: Xiangxi Wang: [email protected]; Cheng-Feng Qin: [email protected]; Feng-Cai Zhu: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083607/
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: National Health Commission of the People's Republic of China; Chinese Academy of Sciences; Nanjing Medical University; Beijing Institute of Microbiology and Epidemiology; Jiangsu Rec-biotechnology Col Ltd.
Keywords: SARS-CoV-2, neutralizing antibodies, immunization, spike protein, immunogenicity, rabbits, primates
Summary of Study: The immunogenic data derived from immunization with a combination of SARS-CoV-2 RBD and NTD demonstrate the feasibility of eliciting robust targeted immune profiles by using antibody-guided vaccine design.
References: PMID: 34676098 / doi: 10.1093/nsr/nwab053
Contact Info: Xiangxi Wang: [email protected]; Cheng-Feng Qin: [email protected]; Feng-Cai Zhu: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083607/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Duke University; UNC Chapel Hill; 3M Corporate Research Materials Laboratory; Infectious Disease Research Institute; California National Primate Research Center; and others
Keywords: SARS-CoV-2, mRNA vaccine, infants, immune response, primates
Summary of Study: Infant rhesus macaques were vaccinated with an mRNA-based SARS-CoV-2 vaccine, similar to the Moderna vaccine, or an S protein plus TLR7/8 agonist-based vaccine. Both vaccines induced profound induction of neutralizing antibody titers, memory B cells responses, and SARS-CV-2 specific CD4+ T cell responses that were long-lasting, all while limiting vaccine related toxicity.
References: PMID: 34131024 / doi: 10.1126/sciimmunol.abj3684
Contact Info: Kristina De Paris: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.abj3684?url_ver=Z39.88-2003&rfr_…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Duke University; UNC Chapel Hill; 3M Corporate Research Materials Laboratory; Infectious Disease Research Institute; California National Primate Research Center; and others
Keywords: SARS-CoV-2, mRNA vaccine, infants, immune response, primates
Summary of Study: Infant rhesus macaques were vaccinated with an mRNA-based SARS-CoV-2 vaccine, similar to the Moderna vaccine, or an S protein plus TLR7/8 agonist-based vaccine. Both vaccines induced profound induction of neutralizing antibody titers, memory B cells responses, and SARS-CV-2 specific CD4+ T cell responses that were long-lasting, all while limiting vaccine related toxicity.
References: PMID: 34131024 / doi: 10.1126/sciimmunol.abj3684
Contact Info: Kristina De Paris: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.abj3684?url_ver=Z39.88-2003&rfr_…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Center for Disease Control and Prevention; Chinese Academy of Medical Sciences & Peking Union Medical College; Chinese Academy of Sciences
Keywords: SARS-CoV-2, mRNA vaccine, nanoparticles, immune response, pathology, mice and primates
Summary of Study: Using both mouse and rhesus macaque SARS-CoV-2 challenge models, this study demonstrates strong immunogenicity, protective ability and high safety profiles of SW0123 (an LPP-based mRA vaccine), and supports this promising candidate for future clinical evaluation.
References: PMID: 34059617 / doi: 10.1038/s41392-021-00634-z
Contact Info: Wenjie Tan: [email protected]; Xiaozhong Peng: [email protected]
URL: https://www.nature.com/articles/s41392-021-00634-z
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Center for Disease Control and Prevention; Chinese Academy of Medical Sciences & Peking Union Medical College; Chinese Academy of Sciences
Keywords: SARS-CoV-2, mRNA vaccine, nanoparticles, immune response, pathology, mice and primates
Summary of Study: Using both mouse and rhesus macaque SARS-CoV-2 challenge models, this study demonstrates strong immunogenicity, protective ability and high safety profiles of SW0123 (an LPP-based mRA vaccine), and supports this promising candidate for future clinical evaluation.
References: PMID: 34059617 / doi: 10.1038/s41392-021-00634-z
Contact Info: Wenjie Tan: [email protected]; Xiaozhong Peng: [email protected]
URL: https://www.nature.com/articles/s41392-021-00634-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: UC Davis, National Institutes of Health (Pakistan), California National Primate Research Center, New York State Department of Health
Keywords: SARS-CoV-2, multiplex test, immune response, primates
Summary of Study: The authors report the development and validation of a multiplex bead assay to simultaneously and specifically detect antibodies to the SARS-CoV-2, SARS-CoV, MERS-CoV and common human coronavirus strains (229E, NL63, OC43, HKU1). Multiplex serological assays enabled the investigation of the dynamics of immune responses in COVID-19 patients.
References: PMID: 34242356 / doi: 10.1371/journal.pone.0254367
Contact Info: Imran Khan: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0254367
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: UC Davis, National Institutes of Health (Pakistan), California National Primate Research Center, New York State Department of Health
Keywords: SARS-CoV-2, multiplex test, immune response, primates
Summary of Study: The authors report the development and validation of a multiplex bead assay to simultaneously and specifically detect antibodies to the SARS-CoV-2, SARS-CoV, MERS-CoV and common human coronavirus strains (229E, NL63, OC43, HKU1). Multiplex serological assays enabled the investigation of the dynamics of immune responses in COVID-19 patients.
References: PMID: 34242356 / doi: 10.1371/journal.pone.0254367
Contact Info: Imran Khan: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0254367
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences, Hynnan Key Laboratory of Vaccine Research, University of Massachusetts Medical School
Keywords: SARS-CoV-2, T cells, immune response, primates
Summary of Study: Six peptides were defined as the most frequently recognized T cell epitopes, and overlapped to produce three main long epitopes. This finding may provide a convenient pattern in the detection of T cell responses for the development of new vaccines and provides a novel target in the diagnosis of patients with COVID-19.
References: PMID: 33980582 / doi: 10.4049/jimmunol.2000922
Contact Info: Wei Cun: [email protected]
URL: https://www.jimmunol.org/content/206/11/2527.long
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences, Hynnan Key Laboratory of Vaccine Research, University of Massachusetts Medical School
Keywords: SARS-CoV-2, T cells, immune response, primates
Summary of Study: Six peptides were defined as the most frequently recognized T cell epitopes, and overlapped to produce three main long epitopes. This finding may provide a convenient pattern in the detection of T cell responses for the development of new vaccines and provides a novel target in the diagnosis of patients with COVID-19.
References: PMID: 33980582 / doi: 10.4049/jimmunol.2000922
Contact Info: Wei Cun: [email protected]
URL: https://www.jimmunol.org/content/206/11/2527.long
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Ottawa; Ottawa Hospital Research Institute; Institut du Cancer de Montreal; University of Calgary
Keywords: SARS-CoV-2, attenuated vaccinia virus vector, spike receptor binding domain, immune response, mice, primates
Summary of Study: Robust immune responses and protective immunity against SARS-CoV-2 variants were demonstrated after only a single dose of a temperature stable vaccine candidate (TOH-Vac1) that uses a replication-competent, attenuated vaccinia virus as a vector to express a membrane-tethered spike receptor binding domain antigen.
References: PMID: 34687845 / doi: 10.1016/j.ymthe.2021.10.008
Contact Info: John Bell: [email protected]; Carolina Ilkow: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1525001621005153?via%3Dihub
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Ottawa; Ottawa Hospital Research Institute; Institut du Cancer de Montreal; University of Calgary
Keywords: SARS-CoV-2, attenuated vaccinia virus vector, spike receptor binding domain, immune response, mice, primates
Summary of Study: Robust immune responses and protective immunity against SARS-CoV-2 variants were demonstrated after only a single dose of a temperature stable vaccine candidate (TOH-Vac1) that uses a replication-competent, attenuated vaccinia virus as a vector to express a membrane-tethered spike receptor binding domain antigen.
References: PMID: 34687845 / doi: 10.1016/j.ymthe.2021.10.008
Contact Info: John Bell: [email protected]; Carolina Ilkow: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1525001621005153?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Shandong Boan Biotech Co., National Institutes for Food and Drug Control, Shuimu Biosciences, and others
Keywords: SARS-CoV-2, neutralizing antibodies, structural analysis, primates
Summary of Study: CA521^FALA is a promising antibody that reacts with SARS-CoV-2 Spike protein to strongly neutralize its activity.
References: PMID: 33893388 / doi: 10.1038/s42003-021-02029-w
Contact Info: Lan Wang: [email protected]; Yong-Qiang Deng: [email protected]; Changlin Dou: [email protected]
URL: https://www.nature.com/articles/s42003-021-02029-w
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Shandong Boan Biotech Co., National Institutes for Food and Drug Control, Shuimu Biosciences, and others
Keywords: SARS-CoV-2, neutralizing antibodies, structural analysis, primates
Summary of Study: CA521^FALA is a promising antibody that reacts with SARS-CoV-2 Spike protein to strongly neutralize its activity.
References: PMID: 33893388 / doi: 10.1038/s42003-021-02029-w
Contact Info: Lan Wang: [email protected]; Yong-Qiang Deng: [email protected]; Changlin Dou: [email protected]
URL: https://www.nature.com/articles/s42003-021-02029-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences; Tsinghua University; Advaccine Biopharmaceuticals (Suzhou)
Keywords: SARS-CoV-2, B cells, Toll-like receptor, preclinical study, virus-like particle, pathogen-like antigen, primates
Summary of Study: A PLA-based COVID-19 vaccine candidate could potentially serve as an alternative option for coping with the SARS-CoV-2 pandemic.
References: PMID: 34723223 / doi: 10.1016/j.xcrm.2021.100448
Contact Info: Zhaolin Hua: [email protected]; Hongyu Deng: [email protected]; Baidong Hou: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379121003165?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences; Tsinghua University; Advaccine Biopharmaceuticals (Suzhou)
Keywords: SARS-CoV-2, B cells, Toll-like receptor, preclinical study, virus-like particle, pathogen-like antigen, primates
Summary of Study: A PLA-based COVID-19 vaccine candidate could potentially serve as an alternative option for coping with the SARS-CoV-2 pandemic.
References: PMID: 34723223 / doi: 10.1016/j.xcrm.2021.100448
Contact Info: Zhaolin Hua: [email protected]; Hongyu Deng: [email protected]; Baidong Hou: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379121003165?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: ImmunityBio, Inc.; IosBio; Battelle Biomedical Research Center; NantKwest, Inc.
Keywords: SARS-CoV-2, dual-antigen vaccine, adenovirus vector, immune response, virus replication, primates
Summary of Study: In the rhesus macaque model, SC prime vaccination with two oral boosts with the dual-antigen hAd5 S-Fusion + N-ETSD vaccine provides protection from SARS-CoV-2 infection for both nasal and lung airways.
References: PMID: 34603305 / doi: 10.3389/fimmu.2021.729837
Contact Info: Patrick Soon-Shiong: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.729837/full
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: ImmunityBio, Inc.; IosBio; Battelle Biomedical Research Center; NantKwest, Inc.
Keywords: SARS-CoV-2, dual-antigen vaccine, adenovirus vector, immune response, virus replication, primates
Summary of Study: In the rhesus macaque model, SC prime vaccination with two oral boosts with the dual-antigen hAd5 S-Fusion + N-ETSD vaccine provides protection from SARS-CoV-2 infection for both nasal and lung airways.
References: PMID: 34603305 / doi: 10.3389/fimmu.2021.729837
Contact Info: Patrick Soon-Shiong: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.729837/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Oxford, Public Health England, The Pirbright Institute
Keywords: SARS-CoV-2, vaccine, immune response, pathology, primates
Summary of Study: Lung pathology caused by SARS-CoV-2 mediated pneumonia is reduced in rhesus macaques by prior vaccination with ChAdOx1 nCoV-19, which induced neutralising antibody responses after a single intramuscular administration.
References: PMID: 34312487 / doi: 10.1038/s42003-021-02443-0
Contact Info: Sarah Gilbert: [email protected]
URL: https://www.nature.com/articles/s42003-021-02443-0
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Oxford, Public Health England, The Pirbright Institute
Keywords: SARS-CoV-2, vaccine, immune response, pathology, primates
Summary of Study: Lung pathology caused by SARS-CoV-2 mediated pneumonia is reduced in rhesus macaques by prior vaccination with ChAdOx1 nCoV-19, which induced neutralising antibody responses after a single intramuscular administration.
References: PMID: 34312487 / doi: 10.1038/s42003-021-02443-0
Contact Info: Sarah Gilbert: [email protected]
URL: https://www.nature.com/articles/s42003-021-02443-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIAID; University of Colorado School of Medicine
Keywords: SARS-CoV-2, role of T cells in recovery, immune response, primates
Summary of Study: Results suggest that T cells are not critical for recovery from acute SARS-CoV-2 infections in the rhesus macaque model (which develop only mild COVID-19, similar to most humans), pointing toward B cell responses and antibodies as the essential mediators of protection from re-exposure.
References: PMID: 34311582 / doi: 10.1128/mBio.01503-21
Contact Info: Kim Hasenkrug: [email protected]
URL: https://journals.asm.org/doi/10.1128/mBio.01503-21
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIAID; University of Colorado School of Medicine
Keywords: SARS-CoV-2, role of T cells in recovery, immune response, primates
Summary of Study: Results suggest that T cells are not critical for recovery from acute SARS-CoV-2 infections in the rhesus macaque model (which develop only mild COVID-19, similar to most humans), pointing toward B cell responses and antibodies as the essential mediators of protection from re-exposure.
References: PMID: 34311582 / doi: 10.1128/mBio.01503-21
Contact Info: Kim Hasenkrug: [email protected]
URL: https://journals.asm.org/doi/10.1128/mBio.01503-21
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, marmosets
Year Published: 2021
Study Type/Review:
NPRC/Institute: Southwest NPRC
Keywords: SARS-CoV-2, young and old animals, Acute respiratory distress, primates
Summary of Study: Acute respiratory distress in macaques and baboons recapitulates the progression of COVID-19 in humans, making them suitable as models to test vaccines and therapies.
References: PMID: 33340034/doi: 10.1038/s41564-020-00841-4
Contact Info: Deepak Kaushal: [email protected]
URL: https://www.nature.com/articles/s41564-020-00841-4
NHP Species: rhesus macaques, marmosets
Year Published: 2021
Study Type/Review:
NPRC/Institute: Southwest NPRC
Keywords: SARS-CoV-2, young and old animals, Acute respiratory distress, primates
Summary of Study: Acute respiratory distress in macaques and baboons recapitulates the progression of COVID-19 in humans, making them suitable as models to test vaccines and therapies.
References: PMID: 33340034/doi: 10.1038/s41564-020-00841-4
Contact Info: Deepak Kaushal: [email protected]
URL: https://www.nature.com/articles/s41564-020-00841-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Tulane National primate Research Center; Tulane School of Medicine; Duke University Medical Center
Keywords: SARS-CoV-2, anti-SARS-CoV-2 monoclonal antibodies, pharmacokinetics, immune response, primates
Summary of Study: A combination of two high-affinity anti-SARS-CoV-2 monoclonal antibodies (mAbs; C144-LS and C135-LS) effectively blocks development of COVID-19 in the rhesus disease model and accelerates the prospect of clinical studies with this effective antibody combination.
References: PMID: 34869063 / doi: 10.3389/fcimb.2021.753444
Contact Info: Chad Roy: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637877/
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Tulane National primate Research Center; Tulane School of Medicine; Duke University Medical Center
Keywords: SARS-CoV-2, anti-SARS-CoV-2 monoclonal antibodies, pharmacokinetics, immune response, primates
Summary of Study: A combination of two high-affinity anti-SARS-CoV-2 monoclonal antibodies (mAbs; C144-LS and C135-LS) effectively blocks development of COVID-19 in the rhesus disease model and accelerates the prospect of clinical studies with this effective antibody combination.
References: PMID: 34869063 / doi: 10.3389/fcimb.2021.753444
Contact Info: Chad Roy: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637877/
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: National Primate Research Centre, Republic of Korea; Chonnam National University; Korea Cancer Center Hospital; University of Ulsan College of Medicine; Futuristic Animal Resource Centre; Seoul National University; Korea University of Science & Technology; and others.
Keywords: SARS-CoV-2, germinal centers, viral reinfection, lung damage, primates
Summary of Study: The seroconversion observed in macaques, which recapitulates the course of COVID-19 disease in human survivors with mild or moderate symptoms, was consistent with the response of GCs in lymphoid tissues and blood of the human subjects tested.
References: PMID: 34718664 / doi: 10.1093/infdis/jiab535
Contact Info: Jung Joo Hong: [email protected]
URL: https://academic.oup.com/jid/article/224/11/1861/6413652
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: National Primate Research Centre, Republic of Korea; Chonnam National University; Korea Cancer Center Hospital; University of Ulsan College of Medicine; Futuristic Animal Resource Centre; Seoul National University; Korea University of Science & Technology; and others.
Keywords: SARS-CoV-2, germinal centers, viral reinfection, lung damage, primates
Summary of Study: The seroconversion observed in macaques, which recapitulates the course of COVID-19 disease in human survivors with mild or moderate symptoms, was consistent with the response of GCs in lymphoid tissues and blood of the human subjects tested.
References: PMID: 34718664 / doi: 10.1093/infdis/jiab535
Contact Info: Jung Joo Hong: [email protected]
URL: https://academic.oup.com/jid/article/224/11/1861/6413652
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Yerkes National Primate Research Center/Emory University; Emory School of Medicine; Ragon Institute of MGH, MIT and Harvard; The University of Texas Medical Branch; 3M Corporate Research Materials Laboratory; and others.
Keywords: SARS-CoV-2, receptor-binding domain subunit vaccine, neutralizing antibody, immune response, primates
Summary of Study: This study demonstrated the potential benefits of RBD trimer as an immunogen for COVID-19 vaccine using mice and macaque models. Future studies will investigate the durability of the vaccine-induced immune responses and what parameters lead to protection.
References: PMID: 34117252 / doi: 10.1038/s41467-021-23942-y
Contact Info: Rama Rao Amara: [email protected]
URL: https://www.nature.com/articles/s41467-021-23942-y
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Yerkes National Primate Research Center/Emory University; Emory School of Medicine; Ragon Institute of MGH, MIT and Harvard; The University of Texas Medical Branch; 3M Corporate Research Materials Laboratory; and others.
Keywords: SARS-CoV-2, receptor-binding domain subunit vaccine, neutralizing antibody, immune response, primates
Summary of Study: This study demonstrated the potential benefits of RBD trimer as an immunogen for COVID-19 vaccine using mice and macaque models. Future studies will investigate the durability of the vaccine-induced immune responses and what parameters lead to protection.
References: PMID: 34117252 / doi: 10.1038/s41467-021-23942-y
Contact Info: Rama Rao Amara: [email protected]
URL: https://www.nature.com/articles/s41467-021-23942-y
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: EcoHealth Alliance; Deakin University; Institute of Epidemiology, Disease Control and Research (Dhaka, Bangladesh); University of Dhaka; Chattogram Veterinary and Animal Sciences University
Keywords: SARS-CoV-2, meta analysis, virus transmission, public health, susceptible animal species, primates
Summary of Study: The continuing spillover and spillback of SARS-CoV-2 in a wide range of animals in farming, captive and free-ranging interfaces make inferences for human and animal health, welfare and conservation. Pets, farmed and captive wild animals should be vaccinated in accordance with vaccination in humans.
References: PMID: 34694705 / doi: 10.111/tbed.14356
Contact Info: Ariful Islam: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1111/tbed.14356
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: EcoHealth Alliance; Deakin University; Institute of Epidemiology, Disease Control and Research (Dhaka, Bangladesh); University of Dhaka; Chattogram Veterinary and Animal Sciences University
Keywords: SARS-CoV-2, meta analysis, virus transmission, public health, susceptible animal species, primates
Summary of Study: The continuing spillover and spillback of SARS-CoV-2 in a wide range of animals in farming, captive and free-ranging interfaces make inferences for human and animal health, welfare and conservation. Pets, farmed and captive wild animals should be vaccinated in accordance with vaccination in humans.
References: PMID: 34694705 / doi: 10.111/tbed.14356
Contact Info: Ariful Islam: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1111/tbed.14356
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Tulane University Information Technology
Keywords: SARS-CoV-2, whole-blood transcriptome profiling, primates
Summary of Study: Hallmark similarities and differences in the RM and AGM acute response to SARS-CoV-2 infection were discovered and may help guide the selection of particular NHP species in modeling aspects of COVID-19 disease outcome.
References: PMID: 34691074 / doi: 10.3389/fimmu.2021.754642
Contact Info: Joseph Mudd: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.754642/full
NHP Species: african green monkeys, rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Tulane University Information Technology
Keywords: SARS-CoV-2, whole-blood transcriptome profiling, primates
Summary of Study: Hallmark similarities and differences in the RM and AGM acute response to SARS-CoV-2 infection were discovered and may help guide the selection of particular NHP species in modeling aspects of COVID-19 disease outcome.
References: PMID: 34691074 / doi: 10.3389/fimmu.2021.754642
Contact Info: Joseph Mudd: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.754642/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Columbia University, University of Texas Medical Branch, Case Western Reserve School of Medicine, and others
Keywords: SARS-CoV-2, peptide-based vaccine targeting MHC class I epitopes, immune response, pathology, primates
Summary of Study: A room temperature stable peptide vaccine based on known immunogenic HLA class I bound CTL epitopes from the nucleocapsid protein can provide protection against SARS-CoV-2 infection in nonhuman primates.
References: PMID: 34070152 / doi: 10.3390/vaccines9050520
Contact Info: Jason Comer: [email protected]; Reid Rubsamen: [email protected]
URL: https://www.mdpi.com/2076-393X/9/5/520
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Columbia University, University of Texas Medical Branch, Case Western Reserve School of Medicine, and others
Keywords: SARS-CoV-2, peptide-based vaccine targeting MHC class I epitopes, immune response, pathology, primates
Summary of Study: A room temperature stable peptide vaccine based on known immunogenic HLA class I bound CTL epitopes from the nucleocapsid protein can provide protection against SARS-CoV-2 infection in nonhuman primates.
References: PMID: 34070152 / doi: 10.3390/vaccines9050520
Contact Info: Jason Comer: [email protected]; Reid Rubsamen: [email protected]
URL: https://www.mdpi.com/2076-393X/9/5/520
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Southern Medical University, Shenzhen; Guangzhou Center for Disease Control and Prevention
Keywords: SARS-CoV-2, adenovirus vectored COVID-19 vaccine, immune response, pathology, primates
Summary of Study: Prime-boost immunization with Sad23L-nCoV-S and Ad49L-nCoV-S (both carrying the full-length of SARS-CoV-2 spike protein gene) can safely elicit strong immunity in animals.
References: PMID: 33993845 / doi: 10.1080/22221751.2021.1931466
Contact Info: Yuming Zhang: [email protected]; Tingting Li: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1931466
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Southern Medical University, Shenzhen; Guangzhou Center for Disease Control and Prevention
Keywords: SARS-CoV-2, adenovirus vectored COVID-19 vaccine, immune response, pathology, primates
Summary of Study: Prime-boost immunization with Sad23L-nCoV-S and Ad49L-nCoV-S (both carrying the full-length of SARS-CoV-2 spike protein gene) can safely elicit strong immunity in animals.
References: PMID: 33993845 / doi: 10.1080/22221751.2021.1931466
Contact Info: Yuming Zhang: [email protected]; Tingting Li: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1931466
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Korea Advanced Institute of Science & Technology, GENOME INSIGHT, INC.
Keywords: SARS-CoV-2, infection models, organoids, primates
Summary of Study: Review of in vitro and in vivo models for SARS-CoV-2 infection.
References: PMID: 34187969 / doi: 10.14348/molcells.2021.0094
Contact Info: Young Seok Ju: [email protected]
URL: https://www.molcells.org/journal/view.html?doi=10.14348/molcells.2021.0094
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Korea Advanced Institute of Science & Technology, GENOME INSIGHT, INC.
Keywords: SARS-CoV-2, infection models, organoids, primates
Summary of Study: Review of in vitro and in vivo models for SARS-CoV-2 infection.
References: PMID: 34187969 / doi: 10.14348/molcells.2021.0094
Contact Info: Young Seok Ju: [email protected]
URL: https://www.molcells.org/journal/view.html?doi=10.14348/molcells.2021.0094
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NCI/NIH; University of Maryland, BIOQUAL, NIAID and others
Keywords: SARS-CoV-2, adjuvanted subunit vaccines, immune response, primates
Summary of Study: Mucosal vaccine efficiently cleared virus in the nasal cavity and may act as a potent complementary reinforcing boost for conventional systemic vaccines to provide overall better protection.
References: PMID: 33908897 / doi: 10.1172/jci.insight.148494
Contact Info: Yongjun Sui: [email protected]; Jay Berzofsky: [email protected]
URL: https://insight.jci.org/articles/view/148494
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NCI/NIH; University of Maryland, BIOQUAL, NIAID and others
Keywords: SARS-CoV-2, adjuvanted subunit vaccines, immune response, primates
Summary of Study: Mucosal vaccine efficiently cleared virus in the nasal cavity and may act as a potent complementary reinforcing boost for conventional systemic vaccines to provide overall better protection.
References: PMID: 33908897 / doi: 10.1172/jci.insight.148494
Contact Info: Yongjun Sui: [email protected]; Jay Berzofsky: [email protected]
URL: https://insight.jci.org/articles/view/148494
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Clover Biopharmaceuticals, Kunming Institute of Zoology
Keywords: SARS-CoV-2, S-Trimer, subunit vaccine candidate, immunogenicity, efficacy, primates
Summary of Study: Rhesus macaques immunized with adjuvanted S-Trimer were protected from SARS-CoV-2 challenge. Trimer-Tag may be an important platform technology for scalable production and rapid development of safe and effective subunit vaccines against current and future emerging RNA viruses.
References: PMID: 33649323 / doi: 10.1038/s41467-021-21634-1
Contact Info: Peng Liang: [email protected]
URL: https://www.nature.com/articles/s41467-021-21634-1
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Clover Biopharmaceuticals, Kunming Institute of Zoology
Keywords: SARS-CoV-2, S-Trimer, subunit vaccine candidate, immunogenicity, efficacy, primates
Summary of Study: Rhesus macaques immunized with adjuvanted S-Trimer were protected from SARS-CoV-2 challenge. Trimer-Tag may be an important platform technology for scalable production and rapid development of safe and effective subunit vaccines against current and future emerging RNA viruses.
References: PMID: 33649323 / doi: 10.1038/s41467-021-21634-1
Contact Info: Peng Liang: [email protected]
URL: https://www.nature.com/articles/s41467-021-21634-1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Beth Israel Deaconess Medical Center, MIT, Harvard
Keywords: SARS-CoV-2, DNA- and Ad26-based vaccines, serum profiles, primates
Summary of Study: Data highlight the similarities between infection and vaccine induced humoral immunity for SARS-Cov-2 and cross-reactivity of these responses to other CoVs.
References: PMID: 33692201 / doi: 10.1128/JVI.00117-21
Contact Info: Dan Barouch: [email protected]
URL: https://journals.asm.org/doi/10.1128/JVI.00117-21?url_ver=Z39.88-2003&rfr_id=or…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Beth Israel Deaconess Medical Center, MIT, Harvard
Keywords: SARS-CoV-2, DNA- and Ad26-based vaccines, serum profiles, primates
Summary of Study: Data highlight the similarities between infection and vaccine induced humoral immunity for SARS-Cov-2 and cross-reactivity of these responses to other CoVs.
References: PMID: 33692201 / doi: 10.1128/JVI.00117-21
Contact Info: Dan Barouch: [email protected]
URL: https://journals.asm.org/doi/10.1128/JVI.00117-21?url_ver=Z39.88-2003&rfr_id=or…
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chungbuk National University
Keywords: SARS-CoV-2, several animal species, transduction, pathology, primates
Summary of Study: Review of various animal models employed for SARS-CoV-2 infection studies that outlines their individual strengths and limitations for use in studies aimed at increasing understanding of coronavirus pathogenesis.
References: PMID: 33996168 / doi: 10.4110/in.2021.21.e12
Contact Info: Young Ki Choi: [email protected]
URL: https://immunenetwork.org/DOIx.php?id=10.4110/in.2021.21.e12
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chungbuk National University
Keywords: SARS-CoV-2, several animal species, transduction, pathology, primates
Summary of Study: Review of various animal models employed for SARS-CoV-2 infection studies that outlines their individual strengths and limitations for use in studies aimed at increasing understanding of coronavirus pathogenesis.
References: PMID: 33996168 / doi: 10.4110/in.2021.21.e12
Contact Info: Young Ki Choi: [email protected]
URL: https://immunenetwork.org/DOIx.php?id=10.4110/in.2021.21.e12
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, cryopreservation, resources, genetic diversity, primates
Summary of Study: The importance of rhesus macaques as a preclinical model for human diseases and treatment outcomes supports the development of improved cryopreservation methods and routine storage of gametes and embryos.
References: PMID: 34031599 / doi: 10.1038/s41684-021-00792-1
Contact Info: Matthew Arnegard: [email protected]
URL: https://www.nature.com/articles/s41684-021-00792-1
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, cryopreservation, resources, genetic diversity, primates
Summary of Study: The importance of rhesus macaques as a preclinical model for human diseases and treatment outcomes supports the development of improved cryopreservation methods and routine storage of gametes and embryos.
References: PMID: 34031599 / doi: 10.1038/s41684-021-00792-1
Contact Info: Matthew Arnegard: [email protected]
URL: https://www.nature.com/articles/s41684-021-00792-1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, pigtail macaques, african green monkeys, squirrel monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIAID
Keywords: SARS-CoV-2, pulmonary histopathologic characteristics, immunohistochemistry, species comparison, primates
Summary of Study: Histopathology does not appear to be a superior readout for interpretation of vaccine and therapeutic evaluations in the NHPs studied. The recommendation of which NHP is a superior model should be based on virology data as well as further work on genetic factors that contribute to significant disease.
References: PMID: 34963391 / doi: 10.1177/03009858211067468
Contact Info: Chad Clancy: [email protected]
URL: https://journals.sagepub.com/doi/10.1177/03009858211067468?url_ver=Z39.88-2003&…
NHP Species: rhesus macaques, pigtail macaques, african green monkeys, squirrel monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIAID
Keywords: SARS-CoV-2, pulmonary histopathologic characteristics, immunohistochemistry, species comparison, primates
Summary of Study: Histopathology does not appear to be a superior readout for interpretation of vaccine and therapeutic evaluations in the NHPs studied. The recommendation of which NHP is a superior model should be based on virology data as well as further work on genetic factors that contribute to significant disease.
References: PMID: 34963391 / doi: 10.1177/03009858211067468
Contact Info: Chad Clancy: [email protected]
URL: https://journals.sagepub.com/doi/10.1177/03009858211067468?url_ver=Z39.88-2003&…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences and Comparative Medicine Center
Keywords: pathogenicity, pneumonia, rhesus macaque model, SARS-CoV-2
Summary of Study: SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys. Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection.
References: doi: 10.1002/ame2.12108
Contact Info: Yu P, et al.; correspondence to Chuan Qin ([email protected]) and Wenjie Tan ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32318665/
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences and Comparative Medicine Center
Keywords: pathogenicity, pneumonia, rhesus macaque model, SARS-CoV-2
Summary of Study: SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys. Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection.
References: doi: 10.1002/ame2.12108
Contact Info: Yu P, et al.; correspondence to Chuan Qin ([email protected]) and Wenjie Tan ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32318665/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: National Institute of Biologicals, Noida, India
Keywords: SARS-CoV-2, many species, review
Summary of Study: This review article finds the rhesus macaque most closely resembles the SARS-CoV-2 infection observed in humans.
References: PMID: 33283030/doi: 10.1007/s13337-020-00637-4
Contact Info: Suresh Kumar: [email protected]
URL: https://link.springer.com/article/10.1007/s13337-020-00637-4
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: National Institute of Biologicals, Noida, India
Keywords: SARS-CoV-2, many species, review
Summary of Study: This review article finds the rhesus macaque most closely resembles the SARS-CoV-2 infection observed in humans.
References: PMID: 33283030/doi: 10.1007/s13337-020-00637-4
Contact Info: Suresh Kumar: [email protected]
URL: https://link.springer.com/article/10.1007/s13337-020-00637-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: University of Washington, Washington National Primate Research Center
Keywords: coronavirus, SARS-CoV-2, vaccine, RNA, replicon, nanoparticle, nonhuman primate
Summary of Study: Single-dose intramuscular vaccination with LION/repRNA-CoV2S elicited antibody responses that potently neutralized SARS-CoV-2 in pigtail macaques.
References: doi: 10.1101/2020.05.28.121640; Preprint
Contact Info: Erasmus JH, et al.; correspondence to Deborah Fuller ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32511417/
NHP Species: pigtail macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: University of Washington, Washington National Primate Research Center
Keywords: coronavirus, SARS-CoV-2, vaccine, RNA, replicon, nanoparticle, nonhuman primate
Summary of Study: Single-dose intramuscular vaccination with LION/repRNA-CoV2S elicited antibody responses that potently neutralized SARS-CoV-2 in pigtail macaques.
References: doi: 10.1101/2020.05.28.121640; Preprint
Contact Info: Erasmus JH, et al.; correspondence to Deborah Fuller ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32511417/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Institute of Human Virology, Guangdong, China
Keywords: SARS-CoV-2, nanoparticle vaccine, primates
Summary of Study: Nanoparticle vaccines (developed by covalently conjugating the self-assembled 24-mer ferritin to the receptor binding domain (RBD) and/or heptad repeat (HR) subunits of the SARS-CoV-2 spike protein) induced neutralizing antibodies, and T and B cell responses prior to boost immunization in rhesus macaques.
References: PMID: 33275896/doi: 10.1016/j.immuni.2020.11.015
Contact Info: Hui Zhang: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1074761320305021?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Institute of Human Virology, Guangdong, China
Keywords: SARS-CoV-2, nanoparticle vaccine, primates
Summary of Study: Nanoparticle vaccines (developed by covalently conjugating the self-assembled 24-mer ferritin to the receptor binding domain (RBD) and/or heptad repeat (HR) subunits of the SARS-CoV-2 spike protein) induced neutralizing antibodies, and T and B cell responses prior to boost immunization in rhesus macaques.
References: PMID: 33275896/doi: 10.1016/j.immuni.2020.11.015
Contact Info: Hui Zhang: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1074761320305021?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Karolinska Institutet, Stockholm
Keywords: SARS-CoV-2, spike trimers, neutralizing antibodies, mice, primates
Summary of Study: Adjuvanted protein intramuscular immunization with SARS-CoV-2 spike trimers, stabilized in prefusion conformation, results in potent antibody responses in mice and rhesus macaque.
References: doi:10.1101/2020.07.31.228486
Contact Info: Mandolesi, Marco; [email protected], [email protected], [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.07.31.228486v1
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Karolinska Institutet, Stockholm
Keywords: SARS-CoV-2, spike trimers, neutralizing antibodies, mice, primates
Summary of Study: Adjuvanted protein intramuscular immunization with SARS-CoV-2 spike trimers, stabilized in prefusion conformation, results in potent antibody responses in mice and rhesus macaque.
References: doi:10.1101/2020.07.31.228486
Contact Info: Mandolesi, Marco; [email protected], [email protected], [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.07.31.228486v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: NIAID
Keywords: coronavirus, SARS-CoV-2, MERS-CoV, vaccine
Summary of Study: Rhesus macaques vaccinated intramuscularly with ChAdOx1 nCoV-19 showed humoral and cellular immune response. The authors observed a significantly reduced viral load in bronchoalveolar lavage fluid and respiratory tract tissues of vaccinated animals challenged with SARS-CoV-2 compared with control animals, and no pneumonia was observed in the vaccinated animals.
References: doi: 10.1101/2020.05.13.093195; Preprint; PMID: 32511340
Contact Info: van Doremalen N, et al.; correspondence to Vincent Munster ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32511340/
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: NIAID
Keywords: coronavirus, SARS-CoV-2, MERS-CoV, vaccine
Summary of Study: Rhesus macaques vaccinated intramuscularly with ChAdOx1 nCoV-19 showed humoral and cellular immune response. The authors observed a significantly reduced viral load in bronchoalveolar lavage fluid and respiratory tract tissues of vaccinated animals challenged with SARS-CoV-2 compared with control animals, and no pneumonia was observed in the vaccinated animals.
References: doi: 10.1101/2020.05.13.093195; Preprint; PMID: 32511340
Contact Info: van Doremalen N, et al.; correspondence to Vincent Munster ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32511340/
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2020
Study Type/Review:
NPRC/Institute: Tongji Medical College, Wuhan, China
Keywords: SARS, ACE2, receptor-binding domain, pneumonia
Summary of Study: The authors analyzed 82 representative ACE2 sequences from the 1000 sequences with the closest homology to the human ACE2 protein to identify potential SARS-CoV-2 natural and intermediate hosts, as well as susceptible animals. Results suggest that several NHPs may be intermediate hosts and most are susceptible to SARS-CoV-2.
References: doi: 10.26434/chemrxiv.12057996.v1; Preprint
Contact Info: Wu C, et al.; correspondence to Hui Li ([email protected])
URL: https://europepmc.org/article/ppr/ppr138914
NHP Species: multiple species
Year Published: 2020
Study Type/Review:
NPRC/Institute: Tongji Medical College, Wuhan, China
Keywords: SARS, ACE2, receptor-binding domain, pneumonia
Summary of Study: The authors analyzed 82 representative ACE2 sequences from the 1000 sequences with the closest homology to the human ACE2 protein to identify potential SARS-CoV-2 natural and intermediate hosts, as well as susceptible animals. Results suggest that several NHPs may be intermediate hosts and most are susceptible to SARS-CoV-2.
References: doi: 10.26434/chemrxiv.12057996.v1; Preprint
Contact Info: Wu C, et al.; correspondence to Hui Li ([email protected])
URL: https://europepmc.org/article/ppr/ppr138914
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2020
Study Type/Review:
NPRC/Institute: Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China
Keywords: coronavirus, SARS-CoV-2, ACE2
Summary of Study: Authors conducted sequence and structural analyses of angiotensin-converting enzyme 2 (ACE2) from different species, which sheds some light on cross-species receptor usage of 2019-nCoV.
References: doi: 10.1016/j.jinf.2020.02.013
Contact Info: Li R, et al.; correspondence to Gaiping Zhang ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32092392/
NHP Species: multiple species
Year Published: 2020
Study Type/Review:
NPRC/Institute: Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China
Keywords: coronavirus, SARS-CoV-2, ACE2
Summary of Study: Authors conducted sequence and structural analyses of angiotensin-converting enzyme 2 (ACE2) from different species, which sheds some light on cross-species receptor usage of 2019-nCoV.
References: doi: 10.1016/j.jinf.2020.02.013
Contact Info: Li R, et al.; correspondence to Gaiping Zhang ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32092392/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Department of Molecular Microbiology and Immunology, Saint Louis University
Keywords: SARS-CoV-2, focus forming assay, viral growth kinetics
Summary of Study: Characterization of cells susceptible to SARS-COV-2 and methods for detection of neutralizing antibody by focus forming assay
References: doi: 10.1101/2020.08.20.259838
Contact Info: E. Taylor Stone et al; Amelia K. Pinto, [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.08.20.259838v1
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Department of Molecular Microbiology and Immunology, Saint Louis University
Keywords: SARS-CoV-2, focus forming assay, viral growth kinetics
Summary of Study: Characterization of cells susceptible to SARS-COV-2 and methods for detection of neutralizing antibody by focus forming assay
References: doi: 10.1101/2020.08.20.259838
Contact Info: E. Taylor Stone et al; Amelia K. Pinto, [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.08.20.259838v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2020
Study Type/Review:
NPRC/Institute: BGi (China) and others
Keywords: single-cell transcriptomics, nonhuman primate, COVID-19, SARS-CoV-2, ACE2, TMPRSS2, kidney, interleukin 6, STAT transcription factors, immune cell exhaustion
Summary of Study: A single-cell transcriptome atlas of nine monkey tissues was used to study COVID-19. ACE2+TMPRSS2+ epithelial cells of lung, kidney and liver were shown to be targets for SARS-CoV-2. ACE2 correlation analysis identifies IDO2 and ANPEP as potential therapeutic opportunities.
References: doi: 10.1101/2020.04.10.022103; Preprint
Contact Info: Han L, et al.; correspondence to Xun Xu ([email protected])
URL: https://www.biorxiv.org/content/10.1101/2020.04.10.022103v2.abstract
NHP Species:
Year Published: 2020
Study Type/Review:
NPRC/Institute: BGi (China) and others
Keywords: single-cell transcriptomics, nonhuman primate, COVID-19, SARS-CoV-2, ACE2, TMPRSS2, kidney, interleukin 6, STAT transcription factors, immune cell exhaustion
Summary of Study: A single-cell transcriptome atlas of nine monkey tissues was used to study COVID-19. ACE2+TMPRSS2+ epithelial cells of lung, kidney and liver were shown to be targets for SARS-CoV-2. ACE2 correlation analysis identifies IDO2 and ANPEP as potential therapeutic opportunities.
References: doi: 10.1101/2020.04.10.022103; Preprint
Contact Info: Han L, et al.; correspondence to Xun Xu ([email protected])
URL: https://www.biorxiv.org/content/10.1101/2020.04.10.022103v2.abstract
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: SWNPRC/Regeneron
Keywords: SARS-CoV-2, neutralizing antibody therapy, primates
Summary of Study: REGN-COV2, a cocktail of two potent neutralizing antibodies (REGN10987+REGN10922) can greatly reduce virus load in lower and upper airway and decrease virus induced pathological sequelae when administered prophylactically or therapeutically.
References: doi: 10.1101/2020.08.02.233320
Contact Info: Baum, A., et al; correspondence to C.A. Kyratsous, [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.08.02.233320v1
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: SWNPRC/Regeneron
Keywords: SARS-CoV-2, neutralizing antibody therapy, primates
Summary of Study: REGN-COV2, a cocktail of two potent neutralizing antibodies (REGN10987+REGN10922) can greatly reduce virus load in lower and upper airway and decrease virus induced pathological sequelae when administered prophylactically or therapeutically.
References: doi: 10.1101/2020.08.02.233320
Contact Info: Baum, A., et al; correspondence to C.A. Kyratsous, [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.08.02.233320v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: crab-eating macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: NIAID
Keywords: SARS-CoV-2, serial computed tomography, positron emission tomography, FDG
Summary of Study: Crab-eating macaques were exposed to SARS-CoV-2 via direct bilateral primary intrabronchial instillation, which resulted in mild-moderate COVID-19 symptoms.
References: doi: 10.1101/2020.05.14.096727; PMID: 32511338
Contact Info: Finch CL, et al.; correspondence to Thomas Friedrich ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32511338/
NHP Species: crab-eating macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: NIAID
Keywords: SARS-CoV-2, serial computed tomography, positron emission tomography, FDG
Summary of Study: Crab-eating macaques were exposed to SARS-CoV-2 via direct bilateral primary intrabronchial instillation, which resulted in mild-moderate COVID-19 symptoms.
References: doi: 10.1101/2020.05.14.096727; PMID: 32511338
Contact Info: Finch CL, et al.; correspondence to Thomas Friedrich ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32511338/
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2020
Study Type/Review:
NPRC/Institute: Jiaotong Univ. Health Science Center, Xi'an, Shaanxi, China
Keywords: SARS-CoV-2, phylogeny and expression pattern of ACE2; variety of animals, including primates
Summary of Study: Using bioinformatics tools to screen for the presence of angiotensin converting enzyme 2 (ACE2) in a variety of tissues in various animals, the authors found that the tissue presence of this enzyme marks the tissues vulnerable to SARS-CoV-2 infection. The pattern of infection in cynomolgus macaques was similar to that in humans.
References: PMID: 33364494/doi: 10.1016/j.heliyon.2020.e05725
Contact Info: Enqi Liu: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2405844020325688?via%3Dihub
NHP Species:
Year Published: 2020
Study Type/Review:
NPRC/Institute: Jiaotong Univ. Health Science Center, Xi'an, Shaanxi, China
Keywords: SARS-CoV-2, phylogeny and expression pattern of ACE2; variety of animals, including primates
Summary of Study: Using bioinformatics tools to screen for the presence of angiotensin converting enzyme 2 (ACE2) in a variety of tissues in various animals, the authors found that the tissue presence of this enzyme marks the tissues vulnerable to SARS-CoV-2 infection. The pattern of infection in cynomolgus macaques was similar to that in humans.
References: PMID: 33364494/doi: 10.1016/j.heliyon.2020.e05725
Contact Info: Enqi Liu: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2405844020325688?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: National Infection Service, Public Health England (PHE)
Keywords: SARS-CoV-2, virus replication, lung histopathology, primates
Summary of Study: SARS-CoV-2 replicates in the upper and lower respiratory tract and causes pulmonary lesions in both rhesus and cynomolgus macaques, resembling the mild clinical cases of COVID-19 in humans.
References: doi:10.1101/2020.09.17.301093
Contact Info: Francisco J. Salguero et al; Miles W. Carroll, [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.09.17.301093v1
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: National Infection Service, Public Health England (PHE)
Keywords: SARS-CoV-2, virus replication, lung histopathology, primates
Summary of Study: SARS-CoV-2 replicates in the upper and lower respiratory tract and causes pulmonary lesions in both rhesus and cynomolgus macaques, resembling the mild clinical cases of COVID-19 in humans.
References: doi:10.1101/2020.09.17.301093
Contact Info: Francisco J. Salguero et al; Miles W. Carroll, [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.09.17.301093v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Institute of Basic Medical Sciences, Beijing, China
Keywords: SARS-CoV-2, pathogenesis, aryl hydrocarbon receptor (AhR) signaling, mucus, primates
Summary of Study: Findings potentially explain the silent hypoxia formation in COVID-19 patients, and suggest a possible intervention strategy by targeting the aryl hydrocarbon receptor pathway.
References: PMID: 33159154/doi: 10.1038/s41422-020-00435-z
Contact Info: Bo Huang: [email protected]
URL: https://www.nature.com/articles/s41422-020-00435-z
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Institute of Basic Medical Sciences, Beijing, China
Keywords: SARS-CoV-2, pathogenesis, aryl hydrocarbon receptor (AhR) signaling, mucus, primates
Summary of Study: Findings potentially explain the silent hypoxia formation in COVID-19 patients, and suggest a possible intervention strategy by targeting the aryl hydrocarbon receptor pathway.
References: PMID: 33159154/doi: 10.1038/s41422-020-00435-z
Contact Info: Bo Huang: [email protected]
URL: https://www.nature.com/articles/s41422-020-00435-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences, Beijing
Keywords: SARS-CoV-2, ACE2, convalescent plasma, neutralizing monoclonal antibodies
Summary of Study: Two neutralizing monoclonal antibodies (CA1 and CB6 MAbs) against SARS-CoV-2 were isolated and tested in vitro. CB6 showed stronger neutralizing activity and was further tested in rhesus macaques at both prophylactic and treatment settings. Treatment reduced virus titers and significant protection was seen in the prophylactic group.
References: doi: 10.1038/s41586-020-2381-y; PMID: 32454512
Contact Info: Shi R, et al.; correspondence to Fu-sheng Wang ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32454512/
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences, Beijing
Keywords: SARS-CoV-2, ACE2, convalescent plasma, neutralizing monoclonal antibodies
Summary of Study: Two neutralizing monoclonal antibodies (CA1 and CB6 MAbs) against SARS-CoV-2 were isolated and tested in vitro. CB6 showed stronger neutralizing activity and was further tested in rhesus macaques at both prophylactic and treatment settings. Treatment reduced virus titers and significant protection was seen in the prophylactic group.
References: doi: 10.1038/s41586-020-2381-y; PMID: 32454512
Contact Info: Shi R, et al.; correspondence to Fu-sheng Wang ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32454512/
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2020
Study Type/Review:
NPRC/Institute: University of Oxford
Keywords: coronavirus, COVID-19, MERS, SARS, vaccine
Summary of Study: The author reviewed the past and ongoing vaccine development efforts for clinically relevant coronavirus strains with the intention that this information helps in the development of effective and safe vaccines for COVID-19.
References: doi: 10.1007/s40121-020-00300-x
Contact Info: Padron-Regalado E; correspondence to Eriko Padron-Regalado ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32328406/
NHP Species: multiple species
Year Published: 2020
Study Type/Review:
NPRC/Institute: University of Oxford
Keywords: coronavirus, COVID-19, MERS, SARS, vaccine
Summary of Study: The author reviewed the past and ongoing vaccine development efforts for clinically relevant coronavirus strains with the intention that this information helps in the development of effective and safe vaccines for COVID-19.
References: doi: 10.1007/s40121-020-00300-x
Contact Info: Padron-Regalado E; correspondence to Eriko Padron-Regalado ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32328406/
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: US Army Medical Research Institute of Infectious Diseases
Keywords: SARS-CoV-2, pre-screening strategies, primates
Summary of Study: Pre-exposure to SARS-CoV-2 affects biomarker responses in animal models, highlighting a need for robust pre-screening protocols prior to medical countermeasure studies.
References: doi:10.1101/2020.07.06.189803
Contact Info: Keersten M. Ricks;[email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.07.06.189803v2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: US Army Medical Research Institute of Infectious Diseases
Keywords: SARS-CoV-2, pre-screening strategies, primates
Summary of Study: Pre-exposure to SARS-CoV-2 affects biomarker responses in animal models, highlighting a need for robust pre-screening protocols prior to medical countermeasure studies.
References: doi:10.1101/2020.07.06.189803
Contact Info: Keersten M. Ricks;[email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.07.06.189803v2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Wistar Institute, Inovio Pharmaceuticals, Bioqual
Keywords: SARS-CoV-2, DNA vaccine, spike protein, primates
Summary of Study: Rhesus macaques were inoculated with an intradermal (ID)- delivered SARS-CoV-2 spike DNA vaccine, INO-4800, inducing a T cell response and neutralizing antibody response. T and B cell responses after challenge with SARS-CoV-2 results in lower viral loads.
References: doi:10.1101/2020.07.28.225649
Contact Info: Ami Patel; [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.07.28.225649v1
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Wistar Institute, Inovio Pharmaceuticals, Bioqual
Keywords: SARS-CoV-2, DNA vaccine, spike protein, primates
Summary of Study: Rhesus macaques were inoculated with an intradermal (ID)- delivered SARS-CoV-2 spike DNA vaccine, INO-4800, inducing a T cell response and neutralizing antibody response. T and B cell responses after challenge with SARS-CoV-2 results in lower viral loads.
References: doi:10.1101/2020.07.28.225649
Contact Info: Ami Patel; [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.07.28.225649v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Zongshan School of Medicine, Guangdong, China
Keywords: SARS-CoV-2, Nanoparticle Vaccines, mice and primates
Summary of Study: The nanoparticle vaccination of rhesus macaques induced neutralizing antibodies, and T and B cell responses prior to boost immunization; these responses persisted for more than three months. RBD- and HR-based nanoparticles thus present a promising vaccination approach against SARS-CoV-2 and other coronaviruses.
References: PMID: 33275896/doi: 10.1016/j.immuni.2020.11.015
Contact Info: Hui Zhang: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1074761320305021?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Zongshan School of Medicine, Guangdong, China
Keywords: SARS-CoV-2, Nanoparticle Vaccines, mice and primates
Summary of Study: The nanoparticle vaccination of rhesus macaques induced neutralizing antibodies, and T and B cell responses prior to boost immunization; these responses persisted for more than three months. RBD- and HR-based nanoparticles thus present a promising vaccination approach against SARS-CoV-2 and other coronaviruses.
References: PMID: 33275896/doi: 10.1016/j.immuni.2020.11.015
Contact Info: Hui Zhang: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1074761320305021?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: NIAID
Keywords: coronavirus, SARS-CoV-2, animal models
Summary of Study: Rhesus macaques were inoculated with SARS-CoV-2 (isolate nCoV-WA1-2020) via a combination of intratracheal, intranasal, ocular, and oral routes. Outcome established that the rhesus macaque recapitulates moderate disease observed in the majority of human cases.
References: doi: 10.1101/2020.03.21.001628; PMID: 32511299
Contact Info: Munster VJ, et al.; correspondence to Emmie de Wit ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32511299/
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: NIAID
Keywords: coronavirus, SARS-CoV-2, animal models
Summary of Study: Rhesus macaques were inoculated with SARS-CoV-2 (isolate nCoV-WA1-2020) via a combination of intratracheal, intranasal, ocular, and oral routes. Outcome established that the rhesus macaque recapitulates moderate disease observed in the majority of human cases.
References: doi: 10.1101/2020.03.21.001628; PMID: 32511299
Contact Info: Munster VJ, et al.; correspondence to Emmie de Wit ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32511299/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, olive baboons, marmosets
Year Published: 2020
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center
Keywords: SARS-CoV-2, pathology, primates
Summary of Study: SARS-CoV-2 infection leads to acute infection with dynamic cellular and inflammatory flux in the lung that varies across nonhuman primate species
References: doi:10.1101/2020.06.05.136481
Contact Info: Dhiraj Kumar Singh et al; Deepak Kaushal, [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.06.05.136481v1
NHP Species: rhesus macaques, olive baboons, marmosets
Year Published: 2020
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center
Keywords: SARS-CoV-2, pathology, primates
Summary of Study: SARS-CoV-2 infection leads to acute infection with dynamic cellular and inflammatory flux in the lung that varies across nonhuman primate species
References: doi:10.1101/2020.06.05.136481
Contact Info: Dhiraj Kumar Singh et al; Deepak Kaushal, [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.06.05.136481v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Tulane NPRC
Keywords: SARS-CoV-2, pathogenesis, immune response kinetics, blood and lungs, primates
Summary of Study: Investigation of immune events from the acute state up to four weeks post SARS-CoV-2 infection unravels cellular mechanisms of COVID-19 and suggests that NHPs may be appropriate models to test immune therapies.
References: PMID: 33247138/doi: 10.1038/s41467-020-19967-4
Contact Info: M. Vaccari: [email protected]
URL: https://www.nature.com/articles/s41467-020-19967-4
NHP Species: african green monkeys, rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Tulane NPRC
Keywords: SARS-CoV-2, pathogenesis, immune response kinetics, blood and lungs, primates
Summary of Study: Investigation of immune events from the acute state up to four weeks post SARS-CoV-2 infection unravels cellular mechanisms of COVID-19 and suggests that NHPs may be appropriate models to test immune therapies.
References: PMID: 33247138/doi: 10.1038/s41467-020-19967-4
Contact Info: M. Vaccari: [email protected]
URL: https://www.nature.com/articles/s41467-020-19967-4