Caitlin F Tsang,Hardik Patel,Fatim M Kouassi,Binny Khandakar,Luce G St Surin,James A Rouse,Raditya…
Utility of pancreatic tumor scrapings for organoid development and precision medicine strategies
The Journal of pathology
2026-01-27
Wenqian Chen,Gabriel C Lander,Jie Yang
Cryo-EM structures of human ClpXP reveal mechanisms of assembly and proteolytic activation
Nature communications
2026-01-27
Noor M Kotb,Gulay Ulukaya,Anupriya Ramamoorthy,Lina Seojin Park,Julia Tang,Dan Hasson,Prashanth…
TORC1-dependent translation drives chromatin remodeling during the germ-cell-to-maternal transition in Drosophila
The EMBO journal
2026-01-26
Caroline P Kerr,Won Jong Jin,Peng Liu,Joseph J Grudzinski,Carolina A Ferreira,Hansel Comas Rojas…
Priming versus propagating: distinct immune effects of alpha- versus beta-particle emitting radiopharmaceuticals when combined with immune checkpoint inhibition in mice
Nature communications
2026-01-26
Charles A Schurman,Joanna Bons,Jonathon J Woo,Cristal Yee,Qi Liu,Nannan Tao,Tamara Alliston,Peggi…
Tissue and extracellular matrix remodeling of the subchondral bone during osteoarthritis of knee joints as revealed by spatial mass spectrometry imaging
Bone research
2026-01-26
Penelope L Lindsay,Fang Xu,Lei Liu,Panagiotis Boumpas,Andres Reyes,Byoung-Il Je,Mari Ogawa-Ohnishi…
Antagonistic interactions between CLAVATA receptors shape maize ear development
The New phytologist
2026-01-26
Md Sydul Islam,Matthew J Allen
Controlling the Kinetic and Electrochemical Properties of EuII -Containing Complexes Using Peripheral Charges
Inorganic chemistry
2026-01-24
Liam Timms,Mustafa Utkur,Cemre Ariyurek,Miriam Hewlett,Sila Kurugol,Onur Afacan
Fast, Robust T2-IVIM Quantitative MRI With Distortion and Motion-Corrected Multi-Echo EPI
Magnetic resonance in medicine
2026-01-24
Tahmineh Kandelouei,Madeline E Houghton,Mitchell R Lewis,Caroline C Keller,Marco Marchetti,Xiaoyu…
Mating regulates growth, metabolism, and digestive efficiency in the female Drosophila midgut
Proceedings of the National Academy of Sciences of the United States of America
2026-01-23
Amanda N Smolinsky,Alberto A Castro,Theodore Garland,Kevin M Middleton
Mice bred for increased running distance evolve 3D shape differences in the hind limb skeleton but show limited plasticity in response to voluntary exercise
Anatomical record (Hoboken, N.J. : 2007)
2026-01-23
Sixia Huang,Paola Kuri,Jonathan Zou,Adriana Blanco,Maxwell Marshall,Gabriella Rice,Stephen Prouty…
Stress vesicles link epidermal mechanotransduction to stem cell differentiation
Nature communications
2026-01-22
Jiaming Ding,Sarah A French,Christina A Rivera,Arismel Tena Meza,Dominick C Witkowski,K N Houk,Neil…
Hyperpyramidalized alkenes with bond orders near 1.5 as synthetic building blocks
Nature chemistry
2026-01-21
Charles-Antoine Assenmacher,Kathy Mou,Ganwu Li,Kimberly Hsu,Orhan Sahin,Stephen D Cole
Actinomyces sp. detected by next-generation sequencing in paraffin-embedded, formalin-fixed tissues of a dog with severe panophthalmitis and periocular cellulitis
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
2026-01-21
Liudmyla Arifova,Brian S MacTavish,Zane Laughlin,Mithun Nag Karadi Girdhar,Jinsai Shang,Min-Hsuan…
Shifting the PPARγ conformational ensemble toward a transcriptionally repressive state improves covalent inhibitor efficacy
eLife
2026-01-21
Hanne Van der Heijden,Gabrielle Alonzi,Amanda Cao,Raquel van Gool,Merve Koç Yekedüz,Lise Vrolix…
Fronto-cerebellar features associate with cognitive dysfunction in childhood-onset systemic lupus erythematosus
Seminars in arthritis and rheumatism
2026-01-21
Liming Zhao,Kyle L O'Donnell,Megha Dubey,Yuting Wang,Nathan R Martinez,Yunxiao Zhang,Holly M…
Engineered mucus-tethering bispecific nanobodies enhance mucosal immunity against respiratory pathogens
Nature nanotechnology
2026-01-21
Daniele Neri,Seoeun Lee,Alexis M Fohn,Xinhong Chen,Dominique Bozec,Alexandre J Lafond,Natalie R…
Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance
Nature metabolism
2026-01-20
Lucas W Remedios,Chloe Cho,Trent M Schwartz,Dingjie Su,Gaurav Rudravaram,Chenyu Gao,Aravind R…
Lifespan Pancreas Morphology for Control Versus Type 2 Diabetes Using AI on Largescale Clinical Imaging
Clinical anatomy (New York, N.Y.)
2026-01-20
Jamie J Arnold,Sean M Braet,Luiz C Vieira,Ibrahim M Moustafa,David W Gohara,Julia A Fecko,Yuan-Wei…
A fold switch regulates conformation of an alphavirus RNA-dependent RNA polymerase
Nucleic acids research
2026-01-20
Nicholas Gladman,Andrew Olson,Sunita Kumari,Sharon Wei,Kapeel Chougule,Zhenyuan Lu,Marcela K Tello…
SorghumBase: a knowledgebase for sorghum genomics, phenomics, and stakeholder engagement
Genetics
2026-01-19
Yu-Hao Wang,Isabelle D'Amico,Jocelyn Whalen,Steven J Mullett,Stacy L Gelhaus,Vaughn S Cooper…
Experimental evolution in the cystic fibrosis chemical environment reveals early TCA cycle flux as a central regulator of Mycobacterium abscessus biofilm formation
Biofilm
2026-01-19
James M Considine,Clarissa Gomez,Dharma Pally,Ning Yang,Isra N Taha,Jenna Sorenson,Erin G Brooks…
Comparative proteomic analysis of the ECM composition of the human omentum and mesentery, the main sites of ovarian cancer metastasis
iScience
2026-01-19
Lindsay C Hanford,Tom Hilbert,Tobias Kober,Randy L Buckner,Ross W Mair
Optimizing ultra-rapid compressed-sensing MPRAGE acquisitions for brain morphometry
Frontiers in neuroimaging
2026-01-19
David Z Zee,Soo Hyun Ahn,Andrew M Crawford,Niharika Sinha,Qiaoling Jin,Chris Jacobsen,Evan Maxey…
Substrate and standard evaluation for correlative elemental mapping of biological samples by X-ray fluorescence microscopy and laser ablation ICP-MS
Journal of analytical atomic spectrometry
2026-01-19
Charles Preston Neff,Janet Siebert,Mallory Karr,Ricky Lippincott,Rachel Kvaal,Amy T Noe,Elena Wall…
Gut microbiome composition influences immunologic alterations in the blood and gut of HIV-positive and HIV-negative men who have sex with men
Frontiers in immunology
2026-01-19
Parul Sirohi,Brooke E Silverstein,Yulia Shmidov,Sonal Deshpande,Joy Tong,Yvonne Y Ma,Chinmay S…
All-PEG-Like Block Copolymers Self-Assemble into Stealth Nanocarriers for Drug Delivery
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
2026-01-18
Pritha Mukherjee,Julius Benicky,Aswini Panigrahi,Laurie Ailles,Radoslav Goldman
SULF1 in Cancer Associated Fibroblasts Promotes Invasion in Head and Neck Cancer Cell Lines
Cancer medicine
2026-01-18
Saurin Kantesaria,Efraín Torres,Mazin M Mustafa,Djaudat Idiyatullin,Sara Ponticorvo,Gregor Adriany…
Designing B1 -Selective Pulses by Frequency Modulating in a Second Rotating Frame
Magnetic resonance in medicine
2026-01-18
Koshlan Mayer-Blackwell,Anastasia Minervina,Mikhail Pogorelyy,Puneet Rawat,Melanie R Shapiro,Leeana…
TCR2HLA: Calibrated inference of HLA genotypes from TCR repertoires enables identification of immunologically relevant metaclonotypes
PLoS computational biology
2026-01-16
Deepa Sarkar,Kathleen D Ferar,Mohammad Ghouse Syed,Lisa A Bastarache,Eimear E Kenny,Noura S Abul…
Developing a phenotype risk score for TTR V142I to capture undiagnosed variant transthyretin amyloidosis in health systems
medRxiv : the preprint server for health sciences
2026-01-16
Ashley J Smuder,Vivian Doerr,Cesar E Jacintho Moritz,Jie Li,Branden L Nguyen
Mitochondrial Transporter ABCB10 Protects Against Doxorubicin-Induced Respiratory Muscle Dysfunction Independent of Changes to Diaphragm Accumulation
Journal of cachexia, sarcopenia and muscle
2026-01-16
Kellen M McDonald,Jake J Son,Mikki Schantell,Nathan M Petro,Ryan Glesinger,Hannah J Okelberry,Jason…
Elevated inflammation in people with HIV is associated with aberrant neural oscillations serving selective attention
Journal of neuroinflammation
2026-01-16
Nazia Nazam,Shamza Manzoor,Maryam Shaikh,Morgan L Brown,Janet R Julson,Colin H Quinn,Swatika Butey…
PP2A activation targets MYCN in neuroblastoma
Cell death & disease
2026-01-15
Parisa Foroozandeh,Nihal Kaplan,Dan Xu,Xiaolin Qi,Elif Kayaalp-Nalbant,Stephen D Miller,Kurt Q Lu…
Losartan Alleviates Chemical Burn-Induced Limbal Stem Cell Deficiency: Repurposing a Venerable Anti-Hypertension Drug
Investigative ophthalmology & visual science
2026-01-15
T D Shaw,H Lam,T S Dutt,C M Pearce,I Alshiraihi,A Obregon-Henao,M Henao-Tamayo,S E Maloney Norcross…
Immunopathological outcomes are isolate-dependent in chronic Mycobacterium avium complex pulmonary disease
Disease models & mechanisms
2026-01-15
Bo Xiao,Maureen Mongan,Chia I Ko,Yueh-Chiang Hu,Tony DeFalco,Kenneth D Greis,Ying Xia
Generation and characterization of a Cre-Inducible MAP3K1 Gain-of-Function Model
Disease models & mechanisms
2026-01-15
Zaki Alasmar,Cécilia Tremblay,Roqaie Moqadam,Geidy E Serrano,Thomas G Beach,Alireza Atri,Yi Su…
Gray matter microstructure from in vivo diffusion magnetic resonance imaging reflects post mortem neuropathology severity and clinical progression of Alzheimer's disease
Alzheimer's & dementia : the journal of the Alzheimer's Association
2026-01-14
Junhoe Kim,Farzad Jalali-Yazdi,Brian E Jones,Gary L Westbrook,Eric Gouaux
Cryo-EM of autoantibody-bound NMDA receptors reveals antigenic hotspots in an active immunization model of anti-NMDAR encephalitis
Science advances
2026-01-14
Amanda Z Velez,Jana N Radin,Emily N Kennedy,Joshua B Parsons,Heather M Tong,Emma Jung,Emily Alam…
The innate immune protein calprotectin ablates the bactericidal activity of β-lactam antibiotics
Proceedings of the National Academy of Sciences of the United States of America
2026-01-14
Harrison Ritz,Romy Frömer,Amitai Shenhav
Misspecified models create the appearance of adaptive control during value-based choice
Communications psychology
2026-01-14
Harrison A Fuchs,Yunhui Peng,Shine Ayyapan,Ruben Rosas,Houfang Zhang,Anna R Panchenko,Catherine A…
G34R cancer mutation alters the conformational ensemble and dynamics of the histone H3.3 tails
Nucleic acids research
2026-01-14
Joshua M Jarodsky,Janette B Myers,Steve L Reichow
Reversible lipid-mediated pH-gating of connexin-46/50 by cryo-EM
Nature communications
2026-01-12
Chi Yan,Weifeng Luo,Jinming Yang,Jing Yang,Sheau-Chiann Chen,Kensey Bergdorf,Qianni Hu,Vivian L…
RAS/MEK/PI3K pathway inhibition augments response to CD40 agonism by targeting CD11b+ Bregs thereby overcoming melanoma PD1-resistance
Nature communications
2026-01-12
Tanya T Karagiannis,Ye Chen,Sarah Bald,Albert Tai,Eric R Reed,Sofiya Milman,Stacy L Andersen,Thomas…
Integrative analysis across metagenomic taxonomic classifiers: A case study of the gut microbiome in aging and longevity in the Integrative Longevity Omics Study
PLoS computational biology
2026-01-12
Bing Dai,Lucas Polack,Samantha Moores,Ariana C Calderon-Zavala,Ekaterina E Heldwein
FLARE: A Flow Cytometry-Based Fluorescent Assay for Measuring HSV-1 Nuclear Egress
Bio-protocol
2026-01-12
Daniel O'Reilly,Raymond C Furgal,Vella M Ross,Eric Luu,Katherine Y Gross,Vignesh Hariharan,Ashley…
Presence of phosphodiester backbone, but not nucleobases, in the guide's 3' terminal region is necessary for RISC loading and target cleavage in vitro and in vivo
Nucleic acids research
2026-01-12
Afshin Seyednejad,Tyler J Sacko,Christopher J Babigian,Timothy E Moore,Shiying Xiao,Jennifer C…
Cocaine-Induced Changes in the BRD4 Interactome Identifies Casein Kinase 1 Epsilon as a Therapeutic Target
Journal of neurochemistry
2026-01-12
Soha Mcheik,Hui Wang,Xiaolan Ding,Hao Wei Li,Megan Sykes
Transgenic expression of hCD47 on pig cells provides only partial protection against human macrophage-mediated destruction in human immune system (HIS) mice
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
2026-01-09
Hannah Doyle,Nicole C R McLaughlin,Sarah L Garnaat,Theresa M Desrochers
Cognitive sequences in obsessive-compulsive disorder are supported by frontal cortex ramping activity
Imaging neuroscience (Cambridge, Mass.)
2026-01-09
Ashwini Sri Hari,Alexandria M Chan,Audrey Scholl,Aidan Mulligan,Janint Camacho,Ireland Rose Kearns…
Multiomic Analyses Reveal Brainstem Metabolic Changes in a Mouse Model of Dravet Syndrome
Cells
2026-01-09
Naemeh Pourshafie,Desi C Alexander,Hong Xu,Kechun Yang,Greg Donahue,Xue Lei,Shuo Zhang,Oksana…
ACSS2 upregulation enhances neuronal resilience to aging and tau-associated neurodegeneration
Proceedings of the National Academy of Sciences of the United States of America
2026-01-09
Jin Hwan Park,Emily N Kennedy,Sarvind Tripathi,Avery B Romp,Seth M Rubin,Robert B Bourret,Fitnat H…
Distinct PlzC mechanisms integrate chemotaxis and c-di-GMP signaling to regulate Vibrio cholerae motility and biofilm formation
Proceedings of the National Academy of Sciences of the United States of America
2026-01-09
Biyue Zhu,Zhenhua Liu,Richard Van,Huizhe Wang,Shi Kuang,Yuntao Jia,Erick Calderon Leon,Fan Yang…
Highly sensitive chemiluminescence imaging of misfolded proteins in neurodegenerative models
Proceedings of the National Academy of Sciences of the United States of America
2026-01-09
Jiansi Gao,Marius Brusselmans,Luiz M Carvalho,Marc A Suchard,Guy Baele,Frederick A Matsen
Biological causes and impacts of rugged tree landscapes in phylodynamic inference
Proceedings of the National Academy of Sciences of the United States of America
2026-01-09
Xinlu Han,Jianliang Shen,Junrong Yan,Rahul Tacke,Weiwei Dai,Qingqing Mao,Heineken Queen Daguplo…
Impaired nitrogenous waste clearance promotes hepatocellular carcinoma
Science advances
2026-01-09
Darby Steinman,Alyssa P Petersen,Yasmi Chibber,Caleb Crawford,Pranshu Tyagi,Hannah C Zierden
Vaginal bacteria-derived extracellular vesicles diffuse through human cervicovaginal mucus to enable microbe-host signaling
NPJ biofilms and microbiomes
2026-01-09
Hugo Calligaro,Brian Khov,Keun-Young Kim,Hiep Le,Mark Ellisman,Satchidananda Panda
Neuropsin-expressing cells in the retina affect melanopsin expression and response to light in mice
Scientific reports
2026-01-08
Joseph T Colonel,Jacqueline Becker,Lili Chan,Cara Faherty,Tielman van Vleck,Laura Curtis,Juan…
Acoustic Analysis of Primary Care Patient-provider Conversations to Screen for Cognitive Impairment
medRxiv : the preprint server for health sciences
2026-01-08
Karly A Cody,Andrzej Sokołowski,Emily Johns,Lucah Medina Guerra,Joseph R Winer,Christina B Young…
Characterizing amyloid and tau positron emission tomography-based stages across the clinical continuum
Alzheimer's & dementia : the journal of the Alzheimer's Association
2026-01-08
Amir Z Munir,Alan Gutierrez,Cade J Krawiec,Priyanka Manandhar,Anya C Shyani,Pan Ma,Paul Gougis…
CXCR6+ T Cells Drive Immune Checkpoint Inhibitor Myocarditis
Circulation
2026-01-07
Jessica L Norris,Lindsey O Rogers,Grace Young,Kara G Pytko,Rachel L Dannenberg,Samuel Perreault…
PCNA encircling primer/template junctions is eliminated by exchange of RPA for Rad51: implications for the interplay between human DNA damage tolerance pathways
Nucleic acids research
2026-01-07
Michael R Murphy,Mythily Ganapathi,Esther R Rotlevi,Teresa M Lee,Joshua M Fisher,Megha V Patel…
Pathogenetic mechanisms of muscle-specific ribosomes in dilated cardiomyopathy
Nature cardiovascular research
2026-01-06
Priyanka Parmar,Burcu Karadal-Ferrena,Suryansh Shukla,Andrew Miller,Chenxin Zhang,Cien Huang…
Racial disparity in pro-metastatic tumor microenvironment in treatment naïve breast cancer
NPJ breast cancer
2026-01-06
Patrycia K Zybura,Kyla J Grant,Alison J Frontier
Cationic Cascade Strategy for the Synthesis of Dihydrobenzofuran and Isochromane Scaffolds
Organic letters
2026-01-06
Nicole Welch,Pugazhendhi Kannan,Gangarao Davuluri,Annette Bellar,Amy H Attaway,Saurabh Mishra…
Hyaluronan 35 prevents endotoxin-mediated dysregulated skeletal muscle proteostasis during ethanol exposure
American journal of physiology. Endocrinology and metabolism
2026-01-06
Derrick Thomas,Brittany M Hufft-Martinez,Zarna Lalwani,Vi Pham,Mary Elmeniawi,An J Tran,Jianming Xu…
Loss of Twist1 leads to disruption of ciliary length, endocytic vesicle dynamics, and cell-cell junctions during neural tube formation
Developmental dynamics : an official publication of the American Association of Anatomists
2026-01-06
Satoki Shibata,Matthew Y Wang,Tsuyoshi Imasaki,Hideki Shigematsu,Diego Ugarte La Torre,Yuanyuan Wei…
Structural analysis of a motor with increased mechanical output reveals new transitions in kinesin microtubule motility
Scientific reports
2026-01-06
Anna J Sigmon,Tatiana N Laremore,Hemant Yennawar,Gracie Clare Guerin,Brendan Pelletier,Samreen…
A Green, Facile Method for Selective α‑Bromination of Flavanones
ACS omega
2026-01-05
Naresh Doni Jayavelu,Hady Samaha,Sonia Tandon Wimalasena,Annmarie Hoch,Jeremy P Gygi,Gisela…
Machine learning models predict long COVID outcomes based on baseline clinical and immunologic factors
Communications medicine
2026-01-03
Gayan I Balasooriya,Payal Naik,Tse-Luen Wee,David L Spector
A sub-set of guanine- and cytosine-rich genes are actively transcribed at the nuclear lamin B1 region
Cellular and molecular life sciences : CMLS
2026-01-03
Benjamin L Musher,Spyridoula Vasileiou,Brandon G Smaglo,Catherine S Robertson,Mengfen Wu,Tao Wang…
Autologous multiantigen-targeted T cell therapy for pancreatic cancer: a phase 1/2 trial
Nature medicine
2026-01-02
Karishma Bisht,Daniel R Weilandt,Caitlin H Lamb,Elizaveta Elshina,Cameron Myhrvold,Aartjan J W Te…
Febrile temperature activates the innate immune response by promoting aberrant influenza A virus RNA synthesis
Science advances
2026-01-02
Masayoshi Higuchi,August F Williams,Anna E Stuhlfire,Ariel H Nguyen,David A G Gervasio,Claire E…
FSP1 and histone deacetylases suppress cancer persister cell ferroptosis
Science advances
2026-01-02
Haiyan Lu,Yuan Liu,Hung-Yu Chiang,Hua Zhang,Xudong Shi,Lingjun Li
Exploring the interplay between protein conformational changes and phosphorylation in a pancreatic cancer cell and stellate cell coculture system
Proceedings of the National Academy of Sciences of the United States of America
2026-01-02