Brittani L Schnable,Matthew A Schaich,Vera Roginskaya,Liam P Leary,Tyler M Weaver,Bret D…
Thymine DNA glycosylase combines sliding, hopping, and nucleosome interactions to efficiently search for 5-formylcytosine
Nature communications
2024-10-25
Kavya Phadke,Sergio D'Anna,Estefania Torres Vega,Junhua Xiao,Xianming Lin,Mingliang Zhang…
Atrial cardiomyopathy resulting from loss of plakophilin-2 expression: Response to adrenergic stimulation and implications for the exercise response
The Journal of physiology
2024-10-24
Yang Yang,Deepika Jayaprakash,Satpal S Jhujh,John J Reynolds,Steve Chen,Yanzhe Gao,Jay Ramanlal…
PCNA-binding activity separates RNF168 functions in DNA replication and DNA double-stranded break signaling
Nucleic acids research
2024-10-24
Aysenur Keske,Usha S Polaki,Daniel R Matson
Immunohistochemical Analysis of GATA2 Expression in Endometrium and its Relationship with Hormone Receptor Expression in Benign and Premalignant Endometrial Disorders
Reproductive sciences (Thousand Oaks, Calif.)
2024-10-23
Hoang Anh T Phan,Yanan Chang,Samuel A Eaton,E James Petersson
Thioamide-based fluorescent sensors for dipeptidyl peptidase 4
Chemical communications (Cambridge, England)
2024-10-23
Ebru Yaman,Nicole Heyer,Cintia S de Paiva,Mary Ann Stepp,Stephen C Pflugfelder,Jehan Alam
Mouse Corneal Immune Cell Heterogeneity Revealed by Single-Cell RNA Sequencing
Investigative ophthalmology & visual science
2024-10-21
Daiyong Deng,Habeebunnisa Begum,Tong Liu,Jiangyan Zhang,Qiang Zhang,Ting-Yu Chu,Hong Li,Alexander…
NFAT5 governs cellular plasticity-driven resistance to KRAS-targeted therapy in pancreatic cancer
The Journal of experimental medicine
2024-10-21
Sydney E Prange,Isha N Bhakta,Daria Sysoeva,Grace E Jean,Anjali Madisetti,Hieu H N Le,Ly U Duong…
Dendrite injury triggers neuroprotection in Drosophila models of neurodegenerative disease
Scientific reports
2024-10-21
Zijing Dong,Lawrence L Wald,Jonathan R Polimeni,Fuyixue Wang
Single-shot echo planar time-resolved imaging for multi-echo functional MRI and distortion-free diffusion imaging
Magnetic resonance in medicine
2024-10-21
Zhangying Chen,Kacie P Ford,Mecca B A R Islam,Hanxiao Wan,Hyebin Han,Abhirami Ramakrishnan,Ryan J…
Anti-CD49d Ab treatment ameliorates age-associated inflammatory response and mitigates CD8+ T-cell cytotoxicity after traumatic brain injury
Journal of neuroinflammation
2024-10-19
Avradip Chatterjee,Brad Gallent,Madhusudhanarao Katiki,Chen Qian,Matthew R Harter,Steve Silletti…
The homeodomain regulates stable DNA binding of prostate cancer target ONECUT2
Nature communications
2024-10-19
Julianne A Jorgensen,Candice Choo-Kang,Luyu Wang,Lina Issa,Jack A Gilbert,Gertrude Ecklu-Mensah,Amy…
Toxic Metals Impact Gut Microbiota and Metabolic Risk in Five African-Origin Populations
medRxiv : the preprint server for health sciences
2024-10-17
Alexander O Nedo,Huining Liang,Jaya Sriram,Md Abdur Razzak,Jung-Youn Lee,Chandra Kambhamettu…
CHUP1 restricts chloroplast movement and effector-triggered immunity in epidermal cells
The New phytologist
2024-10-17
Bess P Rosen,Qing V Li,Hyein S Cho,Dingyu Liu,Dapeng Yang,Sarah Graff,Jielin Yan,Renhe Luo,Nipun…
Parallel genome-scale CRISPR-Cas9 screens uncouple human pluripotent stem cell identity versus fitness
Nature communications
2024-10-17
Hanson Tam,Ying Xu,Jinping An,Torsten Schöneberg,Angela Schulz,Jagan R Muppidi,Jason G Cyster
Phosphatidylserine phospholipase A1 enables GPR34-dependent immune cell accumulation in the peritoneal cavity
The Journal of experimental medicine
2024-10-16
Weiping Huang,Chetana Baliga,Elena V Aleksandrova,Gemma Atkinson,Yury S Polikanov,Nora Vázquez…
Activity, structure, and diversity of Type II proline-rich antimicrobial peptides from insects
EMBO reports
2024-10-16
Siliang Song,Jianzhi Zhang
In search of the genetic variants of human sex ratio at birth: was Fisher wrong about sex ratio evolution?
Proceedings. Biological sciences
2024-10-15
Hong Gao,Saliha Pathan,Beverly R E A Dixon,Aarthi Pugazenthi,Megumi Mathison,Tamer M A Mohamed,Todd…
Sall4 and Gata4 induce cardiac fibroblast transition towards a partially multipotent state with cardiogenic potential
Scientific reports
2024-10-15
Randy Hamchand,Kevin Wang,Deguang Song,Noah W Palm,Jason M Crawford
Mucosal sugars delineate pyrazine vs pyrazinone autoinducer signaling in Klebsiella oxytoca
Nature communications
2024-10-15
Thomas Pulliam,Saumya Jani,Peter H Goff,Rashmi Bhakuni,Shira Tabachnick-Cherny,Kimberly Smythe…
Intratumoral STING agonist reverses immune evasion in PD-(L)1-refractory Merkel cell carcinoma: mechanistic insights from detailed biomarker analyses
Journal for immunotherapy of cancer
2024-10-14
Caroline S Jansen,Meghana S Pagadala,Maria A Cardenas,Roshan S Prabhu,Subir Goyal,Chengjing Zhou…
Pre-operative stereotactic radiosurgery and peri-operative dexamethasone for resectable brain metastases: a two-arm pilot study evaluating clinical outcomes and immunological correlates
Nature communications
2024-10-14
Joseph A Caruso,Thea D Tlsty
An adaptive Epithelial-Mesenchymal Transition Program Enables Basal Epithelial Cells to Bypass Stress-Induced Stasis and Contributes to Metaplastic Breast Cancer Progenitor State
Research square
2024-10-14
Xiaomeng Huang,Anthony D Pomicter,Jonathan Ahmann,Yi Qiao,Opal S Chen,Tracy I George,Nataly Cruz…
Clonal dynamics of aggressive systemic mastocytosis on avapritinib therapy
Blood cancer journal
2024-10-14
Murugadas Anbazhagan,Garima Sharma,Shanta Murthy,Sushma Chowdary Maddipatla,Vasantha L Kolachala…
PTGER4 signaling regulates class IIa HDAC function and SPINK4 mRNA levels in rectal epithelial cells
Cell communication and signaling : CCS
2024-10-13
Julio Aleman,Ravikumar K,Connor Wiegand,Mark E Schurdak,Lawrence Vernetti,Dillon Gavlock,Celeste…
A metabolic dysfunction-associated steatotic liver acinus biomimetic induces pancreatic islet dysfunction in a coupled microphysiology system
Communications biology
2024-10-13
Vidhyalakshmi Sridharan,Tara George,Daniel W Conroy,Zach Shaffer,Witold K Surewicz,Christopher P…
Copper binding alters the core structure of amyloid fibrils formed by Y145Stop human prion protein
Physical chemistry chemical physics : PCCP
2024-10-11
Newton Cao,Warda Merchant,Laurent Gautron
Limited evidence for anatomical contacts between intestinal GLP-1 cells and vagal neurons in male mice
Scientific reports
2024-10-10
Colin R Coleman,Judit Pallos,Alicia Arreola-Bustos,Lu Wang,Daniel Raftery,Daniel E L Promislow,Ian…
Natural variation in age-related dopamine neuron degeneration is glutathione dependent and linked to life span
Proceedings of the National Academy of Sciences of the United States of America
2024-10-10
Junwoo Suh,Yehe Liu,Jordan Smith,Michiko Watanabe,Andrew M Rollins,Michael W Jenkins
A Simple and Fast Optical Clearing Method for Whole-Mount Fluorescence In Situ Hybridization (FISH) Imaging
Journal of biophotonics
2024-10-10
Eric M Merten,John D Sears,Tina M Leisner,P Brian Hardy,Anirban Ghoshal,Mohammad Anwar Hossain…
Identification of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach
Proceedings of the National Academy of Sciences of the United States of America
2024-10-10
Yongchun Zhang,Dimitris Karagiannis,Helu Liu,Mi Lin,Yinshan Fang,Ming Jiang,Xiao Chen,Supriya…
Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy
Science advances
2024-10-09
Osman Sharifi,Viktoria Haghani,Kari E Neier,Keith J Fraga,Ian Korf,Sophia M Hakam,Gerald Quon…
Sex-specific single cell-level transcriptomic signatures of Rett syndrome disease progression
Communications biology
2024-10-09
Sarah N Cilvik,Brit Boehmer,Stephanie R Wesolowski,Laura D Brown,Paul J Rozance
Chronic late gestation fetal hyperglucagonaemia results in lower insulin secretion, pancreatic mass, islet area and beta- and α-cell proliferation
The Journal of physiology
2024-10-09
Ghislain Rocheleau,Shoa L Clarke,Gaëlle Auguste,Natalie R Hasbani,Alanna C Morrison,Adam S Heath…
Rare variant contribution to the heritability of coronary artery disease
Nature communications
2024-10-09
Emma K Geiduschek,Emma K Bricco,Colleen M McDowell
DAMPs Drive Fibroinflammatory Changes in the Glaucomatous ONH
Investigative ophthalmology & visual science
2024-10-09
Yaxian Zhou,Chunrong Li,Xuankun Chen,Yuan Zhao,Yaxian Liao,Penghsuan Huang,Wenxin Wu,Nicholas S…
Development of folate receptor targeting chimeras for cancer selective degradation of extracellular proteins
Nature communications
2024-10-08
Nadira Yusif Rodriguez,Aarit Ahuja,Debaleena Basu,Theresa H McKim,Theresa M Desrochers
Different subregions of monkey lateral prefrontal cortex respond to abstract sequences and their components
The Journal of neuroscience : the official journal of the Society for Neuroscience
2024-10-08
Malik Zohaib Ali,Taru S Dutt,Amy MacNeill,Amanda Walz,Camron Pearce,Ha Lam,Jamie S Philp,Johnathan…
A modified BPaL regimen for tuberculosis treatment replaces linezolid with inhaled spectinamides
eLife
2024-10-08
Bradley W Biggs,Morgan N Price,Dexter Lai,Jasmine Escobedo,Yuridia Fortanel,Yolanda Y Huang…
High-throughput protein characterization by complementation using DNA barcoded fragment libraries
Molecular systems biology
2024-10-07
Ilaria Baldassarri,Daniel Naveed Tavakol,Pamela L Graney,Alan G Chramiec,Hanina Hibshoosh,Gordana…
An engineered model of metastatic colonization of human bone marrow reveals breast cancer cell remodeling of the hematopoietic niche
Proceedings of the National Academy of Sciences of the United States of America
2024-10-07
Stephen M Lander,Garth Fisher,Blake A Everett,Peter Tran,Arthur Prindle
Secreted nucleases reclaim extracellular DNA during biofilm development
NPJ biofilms and microbiomes
2024-10-07
Andrew F Mead,Neil B Wood,Shane R Nelson,Bradley M Palmer,Lin Yang,Samantha Beck Previs,Angela…
Functional role of myosin-binding protein H in thick filaments of developing vertebrate fast-twitch skeletal muscle
The Journal of general physiology
2024-10-07
Wanqi Wang,Damian J Williams,Jia Jie Teoh,Divyalakshmi Soundararajan,Aamir Zuberi,Cathleen M Lutz…
Impaired axon initial segment structure and function in a model of ARHGEF9 developmental and epileptic encephalopathy
Proceedings of the National Academy of Sciences of the United States of America
2024-10-07
Shristi Pawnikar,Brenda S Magenheimer,Keya Joshi,Ericka Nevarez-Munoz,Allan Haldane,Robin L Maser…
Activation of polycystin-1 signaling by binding of stalk-derived peptide agonists
eLife
2024-10-07
Stephano M Iglesias,Chun-Feng David Hou,Johnny Reid,Evan Schauer,Renae Geier,Angela Soriaga,Lucy…
Cryo-EM analysis of Pseudomonas phage Pa193 structural components
Communications biology
2024-10-06
Abhjeet S Bhullar,Kai Jin,Haizhu Shi,Austen Jones,Dalton Hironaka,Gaofeng Xiong,Ren Xu,Peixuan Guo…
Engineered extracellular vesicles for combinatorial TNBC therapy: SR-SIM-guided design achieves substantial drug dosage reduction
Molecular therapy : the journal of the American Society of Gene Therapy
2024-10-06
Samantha Bradford,Rohan Joshi,Shangbang Luo,Emily Farrah,Yilu Xie,Donald J Brown,Tibor Juhasz,James…
In Vivo Femtosecond Laser Machined Transepithelial Nonlinear Optical Corneal Crosslinking Compared to Ultraviolet Corneal Crosslinking
Translational vision science & technology
2024-10-04
Christopher H Sollenberger,Ruomeng Qiu,Hiroaki Sai,James K Carrow,Timmy Fyrner,Zijun Gao,Liam C…
Boosting Chondrocyte Bioactivity with Ultra-Sulfated Glycopeptide Supramolecular Polymers
Acta biomaterialia
2024-10-03
Jake D Lehle,Yu-Huey Lin,Amanda Gomez,Laura Chavez,John R McCarrey
An in vitro approach reveals molecular mechanisms underlying endocrine disruptor-induced epimutagenesis
eLife
2024-10-03
Matthew J Elardo,Adelaide M Levenson,Ana Paula Kitos Vasconcelos,Meredith N Pomfret,Matthew R Golder
A general synthesis of cyclic bottlebrush polymers with enhanced mechanical properties via graft-through ring expansion metathesis polymerization
Chemical science
2024-10-03
Daniel C Stewart,Becky K Brisson,Bassil Dekky,Ashton C Berger,William Yen,Elizabeth A Mauldin…
Prognostic and therapeutic implications of tumor-restrictive type III collagen in the breast cancer microenvironment
NPJ breast cancer
2024-10-02
Arvin B Karbasi,Jaden D Barfuss,Theodore C Morgan,Daniel Collins,Drew A Costenbader,David G Dennis…
Sol-moiety: Discovery of a water-soluble prodrug technology for enhanced oral bioavailability of insoluble therapeutics
Nature communications
2024-10-01
Yun Hu,Sébastien Paris,Narayan Sahoo,Qi Wang,Qianxia Wang,Hampartsoum B Barsoumian,Ailing Huang…
Superior antitumor immune response achieved with proton over photon immunoradiotherapy is amplified by the nanoradioenhancer NBTXR3
Journal of nanobiotechnology
2024-10-01
Ravi K Lokareddy,Chun-Feng David Hou,Francesca Forti,Stephano M Iglesias,Fenglin Li,Mikhail…
Integrative structural analysis of Pseudomonas phage DEV reveals a genome ejection motor
Nature communications
2024-10-01
Hector M Nieves-Rosado,Hridesh Banerjee,Angela Gocher-Demske,Priyanka Manandhar,Isha Mehta…
Tim-3 Is Required for Regulatory T Cell-Mediated Promotion of T Cell Exhaustion and Viral Persistence during Chronic Lymphocytic Choriomeningitis Virus Infection
Journal of immunology (Baltimore, Md. : 1950)
2024-09-30
Megan L Ludwig,David Moline,Alec Horrmann,Ella Boytim,Gabrianne Larson,Ali T Arafa,Masooma Sayeda…
Integrated multi-omics assessment of lineage plasticity in a prostate cancer patient with brain and dural metastases
NPJ precision oncology
2024-09-30
Susan Kilgas,Aleem Syed,Patrick Toolan-Kerr,Michelle L Swift,Shrabasti Roychoudhury,Aniruddha…
NEAT1 modulates the TIRR/53BP1 complex to maintain genome integrity
Nature communications
2024-09-30
Matthew J O'Neill,Tao Yang,Julie Laudeman,Maria E Calandranis,M Lorena Harvey,Joseph F Solus…
ParSE-seq: a calibrated multiplexed assay to facilitate the clinical classification of putative splice-altering variants
Nature communications
2024-09-27
Joon S Kang,Kang Zhou,Hui Wang,Sijia Tang,Kristin Van Mouwerik Lyles,Ming Luo,Z Hong Zhou
Architectural organization and in situ fusion protein structure of lymphocytic choriomeningitis virus
Journal of virology
2024-09-27
Léa Ripoll,Yong Li,Carmen W Dessauer,Mark von Zastrow
Spatial organization of adenylyl cyclase and its impact on dopamine signaling in neurons
Nature communications
2024-09-27
Morgan C Finnerty,Franklin E Leach,Yousef Zakharia,Kenneth G Nepple,Michael G Bartlett,Michael D…
Identification of blood lipid markers of docetaxel treatment in prostate cancer patients
Scientific reports
2024-09-27
Sarah E Hickson,Jennifer L Hyde
RNA structures within Venezuelan equine encephalitis virus E1 alter macrophage replication fitness and contribute to viral emergence
PLoS pathogens
2024-09-27
Michael J Neuhoff,Yuchen Wang,Nicholas J Vantangoli,Michael G Poirier,Carlos E Castro,Wolfgang G…
Recycling Materials for Sustainable DNA Origami Manufacturing
Nano letters
2024-09-24
Paul Jongseo Lee,Yu Sun,Alexa R Soares,Caroline Fai,Marina R Picciotto,Junjie U Guo
Alternative translation initiation produces synaptic organizer proteoforms with distinct localization and functions
Molecular cell
2024-09-24
Ari M Selzer,John J Alvarado,Thomas E Smithgall
Cocrystallization of the Src-Family Kinase Hck with the ATP-Site Inhibitor A-419259 Stabilizes an Extended Activation Loop Conformation
Biochemistry
2024-09-24
Andrea N Loes,Rosario Araceli L Tarabi,John Huddleston,Lisa Touyon,Sook San Wong,Samuel M S Cheng…
High-throughput sequencing-based neutralization assay reveals how repeated vaccinations impact titers to recent human H1N1 influenza strains
Journal of virology
2024-09-24
Kyle I Mentkowski,Touba Tarvirdizadeh,Cody A Manzanero,Lisa A Eagler,Jennifer K Lang
Surface engineering enhances the therapeutic potential of systemically delivered extracellular vesicles following acute myocardial infarction
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2024-09-20
Hao Chen,Sohjeong Kim,Chi P Ting
Total Synthesis of (±)-3-Thiaglutamate
Tetrahedron letters
2024-09-19
Khanh V Doan,Timothy S Luongo,Thato T Ts'olo,Won Dong Lee,David W Frederick,Sarmistha…
Cardiac NAD+ depletion in mice promotes hypertrophic cardiomyopathy and arrhythmias prior to impaired bioenergetics
Nature cardiovascular research
2024-09-18
Seth H Pincus,Frances M Cole,Kelli Ober,Monika Tokmina-Lukaszewska,Tamera Marcotte,Ernest W Kovacs…
Conjugation of anti-HIV gp41 monoclonal antibody to a drug capable of targeting resting lymphocytes produces an effective cytotoxic anti-HIV immunoconjugate
Journal of virology
2024-09-16
Jianfeng Lin,Jian Miao,Katherine G Schaefer,Charles M Russell,Robert J Pyron,Fuming Zhang,Quynh T…
Sulfated glycosaminoglycans are host epithelial cell targets of the Candida albicans toxin candidalysin
Nature microbiology
2024-09-16
Shivansh Kaushik,Ta I Hung,Chia-En A Chang
Molecular mechanics studies of factors affecting overall rate in cascade reactions: Multi-enzyme colocalization and environment
Protein science : a publication of the Protein Society
2024-09-14
Michael Shuster,Zhihui Lyu,Jacques Augenstreich,Shrestha Mathur,Akshaya Ganesh,Jiqiang Ling,Volker…
Salmonella Typhimurium infection inhibits macrophage IFNβ signaling in a TLR4-dependent manner
Infection and immunity
2024-09-13
Brian C Richardson,Zachary R Turlington,Sofia Vaz Ferreira de Macedo,Sara K Phillips,Kay Perry…
Structural and Functional Characterization of a Novel Class A Flavin Monooxygenase from Bacillus niacini
Biochemistry
2024-09-12
Hannah Murphy,Qinfeng Huang,Jacob Jensen,Noah Weber,Luiza Mendonça,Hinh Ly,Yuying Liang
Characterization of bi-segmented and tri-segmented recombinant Pichinde virus particles
Journal of virology
2024-09-12
Narayan Datt Soni,Anshuman Swain,Halvor Juul,Quy Cao,Mohammad Haris,David A Wolk,Virginia M-Y Lee…
Detection of sex-specific glutamate changes in subregions of hippocampus in an early-stage Alzheimer's disease mouse model using GluCEST MRI
Alzheimer's & dementia : the journal of the Alzheimer's Association
2024-09-12
Khaled Mohamed Nassar,Xue Yang,Adriana Baker,Rahul Gopalam,William C Arnold,Timilehin T Adeniran…
PELP1 Is a Novel Therapeutic Target in Hepatocellular Carcinoma
Cancer research communications
2024-09-11
John D Hill,Eleftherios T Papoutsakis
Species-specific ribosomal RNA-FISH identifies interspecies cellular-material exchange, active-cell population dynamics and cellular localization of translation machinery in clostridial cultures and co-cultures
mSystems
2024-09-10
Salik Hussain,Nairrita Majumder,Md Habibul Hasan Mazumder,Sara E Lewis,Olanrewaju Olapeju,Murugesan…
Intermittent ozone inhalation during house dust mite-induced sensitization primes for adverse asthma phenotype
Redox biology
2024-09-08
Parul Agrawal,Maria L Knudsen,Anna MacCamy,Nicholas K Hurlburt,Arineh Khechaduri,Kelsey R Salladay…
Short CDRL1 in intermediate VRC01-like mAbs is not sufficient to overcome key glycan barriers on HIV-1 Env
Journal of virology
2024-09-06
Adi N R Poli,Ian Tietjen,Nitesh K Nandwana,Joel Cassel,Troy E Messick,Emery T Register,Frederick…
Design of novel and highly selective SARS-CoV-2 main protease inhibitors
Antimicrobial agents and chemotherapy
2024-09-03
Lily G Beck,Jeffrey B Krall,Parker J Nichols,Quentin Vicens,Morkos A Henen,Beat Vögeli
Solution NMR backbone assignment of the N-terminal tandem Zα1-Zα2 domains of Z-DNA binding protein 1
Biomolecular NMR assignments
2024-08-31
Elijah T Roberts,Alexander R Davis,Jeremy T Risher,Adam W Barb,I Jonathan Amster
Automated Assignment of 15 N And 13 C Enrichment Levels in Doubly-Labeled Proteins
Journal of the American Society for Mass Spectrometry
2024-08-30
Nur-E Alom,Neha Rani,H Bernhard Schlegel,Hien M Nguyen
Highly stereoselective synthesis of α-glycosylated carboxylic acids by phenanthroline catalysis
Organic chemistry frontiers : an international journal of organic chemistry
2024-08-30
Zachary J Kirsch,Jonathan Ashby,Richard W Vachet
Investigating Protein-Nucleic Acid Binding Interactions with Diethylpyrocarbonate Covalent Labeling-Mass Spectrometry
Journal of the American Society for Mass Spectrometry
2024-08-29
Michael A Pitino,Deborah L O'Connor,Sharon Unger,Bum Jin Kim,Alain Doyen,Md Abdul Wazed…
Comparative proteomic analysis of donor human milk treated by high-pressure processing or Holder pasteurization on undigested proteins across dynamic simulated preterm infant digestion
Food chemistry
2024-08-29