Zeng Rong Wong,Binh Khanh Mai,Willi R Berg,Alexander Kvitsinski,Thor L F Correia,Yu Zhang,Peng Liu…
Reactions of Difluorocarbene with Organogold(I) Complexes: Synthesis of Gem-Difluoromethylene Organometallics via Difluorocarbene Insertion and Cycloaddition Reactions
Angewandte Chemie (International ed. in English)
2025-08-14
Shin-La Shu,Shawna Benjamin-Davalos,Xue Wang,Eriko Katsuta,Megan Fitzgerald,Marina Koroleva,Cheryl…
Scaffold-Free Functional Deconvolution Identifies Clinically Relevant Metastatic Melanoma EV Biomarkers
Cancers
2025-08-14
Ameer Mansur,Carlos Gallegos,Andrew Burns,Lily Watts,Seth Lee,Patrick Song,Yun Lu,Anna Sorace
Multiparametric Analysis of PET and Quantitative MRI for Identifying Intratumoral Habitats and Characterizing Trastuzumab-Induced Alterations
Cancers
2025-08-14
Gaoyuan Lu,Shuling Xu,Penghsuan Huang,Lingjun Li
Enhancing Lipidomics With High-Resolution Ion Mobility-Mass Spectrometry
Proteomics
2025-08-13
Clare Moffatt,Pranati Pillutla,Israa A Laklouk,Alden F Smith,Dinesh K Chhetri
Radiation Fibrosis of the Epiglottis: Histopathology and Multiphoton Imaging of Collagen and Elastin
The Laryngoscope
2025-08-13
Steven P Jones,Nathan O'Leary,Ernesto Pena Calderin,Richa A Singhal,Jason Hellmann,Celio Damacena…
Exercise Sensitizes the Pressure Diuresis Response: Shifting Immune Landscapes May Underlie Renal Adaptations to Exercise
American journal of physiology. Renal physiology
2025-08-11
Francesca M Marassi,Guido Pintacuda
Solid-state NMR of membrane proteins in situ
Current opinion in structural biology
2025-08-09
Marie Blanchette,Kaja Bajc,Benjamin D Gastfriend,Caterina P Profaci,Nadine Ruderisch,Cayce E…
Regional heterogeneity of the blood-brain barrier
Nature communications
2025-08-08
Matthew M C Kwan,Nicole B Day,Iain R Konigsberg,Evan Thoresen,Abigail G Harrell,Celeste E Busch…
Particle Shape Modulates the Function of Adoptive Macrophage Transfers
Advanced healthcare materials
2025-08-08
Hila Milo Rasouly,Sarath Babu Krishna Murthy,Natalie Vena,Gundula Povysil,Andrew Beenken,Miguel…
Exome analysis links kidney malformations to developmental disorders and reveals causal genes
Nature communications
2025-08-07
Guanyou Lin,Jianxi Huang,Xinqi Li,Yunshan Liu,Taylor Juenke,Arthur Finstad,Miqin Zhang
A modular polymer platform for efficient mRNA delivery in cancer immunotherapy
Nanoscale horizons
2025-08-07
Bing Han,Sarah M Connolly,Darrin T Schultz,Louis F L Wilson,Alican Gulsevin,Jens Meiler,Erkan…
Evolutionarily diverse caveolins share a common structural framework built around amphipathic disks
The Journal of cell biology
2025-08-07
Wendy Sun,Anne Billot,Jingnan Du,Xiangyu Wei,Rachel A Lemley,Mohammad Daneshzand,Aapo Nummenmaa…
Precision Network Modeling of Transcranial Magnetic Stimulation Across Individuals Suggests Therapeutic Targets and Potential for Improvement
Human brain mapping
2025-08-07
Keri S Rosch,Christian Hyde,Ian Fuelscher,Deana Crocetti,Mervyn Singh,Stewart H Mostofsky
Childhood white matter morphology and longitudinal change in symptoms of attention-deficit/hyperactivity disorder
Developmental medicine and child neurology
2025-08-06
Megan C Hall,Maggie P Rempe,Chloe C Casagrande,Ryan J Glesinger,Nathan M Petro,Grant M Garrison…
Age-related alterations in alpha and beta oscillations support preservation of semantic processing in healthy aging
npj aging
2025-08-06
Simone Sidoli,Mikhail Kislin,Ankita Poojari,Bridget Shafit-Zagardo
Altered Metabolism in Heterozygous Mice With a Mutation in the Motor Domain of Cytoplasmic Dynein, DYNC1H1 (AAA4; c9052C>T(P3018S))
Proteomics
2025-08-06
Aobo Huang,Jinming Zhang,Zhendong Liu,Vanessa Schoen,Deepanjali Verma,Haiyan Zheng,Ullas V Pedmale…
Split-YFP-coupled interaction-dependent TurboID identifies new functions of basal cell polarity in Arabidopsis
Proceedings of the National Academy of Sciences of the United States of America
2025-08-06
Henning Tim Langer,Natalie K Gilmore,Chris M T Hayden,Julien Roux,Bruno Bariohay,Thaïs Rhouquet…
Pharmacological weight loss with incretin-based therapies does not result in a disproportionate loss of muscle mass or function in obese mice and humans
medRxiv : the preprint server for health sciences
2025-08-06
William Dion,Yuren Tao,Maci Chambers,Shanshan Zhao,Riley K Arbuckle,Michelle Sun,Syeda Kubra…
SON-dependent nuclear speckle rehabilitation alleviates proteinopathies
Nature communications
2025-08-05
Lilly F Chiou,Gaith N Droby,Deepika Jayaprakash,Jay R Anand,Xingyuan Zhang,Yang Yang,C Allie Mills…
The RING finger E3 ligase RNF25 protects DNA replication forks independently of its canonical roles in ubiquitin signaling
Nature communications
2025-08-05
John M Bennett,Andrew R Bortz,Zheyuan Wang,Muhammed Fastheem,Rudi Fasan
Chemoenzymatic Skeletal Editing of Natural Product Scaffolds via P450-Controlled Site-Selective Ring Expansion at Aliphatic C─H Sites
Angewandte Chemie (International ed. in English)
2025-08-04
Guohua Lv,Nicole M Sayles,Yun Huang,Chiara Mancinelli,Kevin McAvoy,Neil A Shneider,Giovanni…
Amyloid fibril structures link CHCHD10 and CHCHD2 to neurodegeneration
Nature communications
2025-08-02
Maniselvan Kuppusamy,Matteo Ottolini,Yen-Lin Chen,Zdravka Daneva,Jie Li,Caroline Heng-Mae Cheung…
Paracrine Smooth Muscle-to-Endothelial Signaling via TNF Elevates Blood Pressure in Obesity
Circulation research
2025-08-01
Jessica C Sieren,Kimberly E Schroeder,Jacob Kitzmann,Kevin Knoernschild,Jarron Atha,Natally Alarab…
Ultra-high Resolution Photon Counting Detector Computed Tomography Imaging for Quantitative Lung Assessment: An Anthropomorphic Phantom Study
Investigative radiology
2025-08-01
Keith Tompkins,Will Boswell,Kang Du,Zhao Lai,Yuan Lu,Molly R Morris
Composition and function of the nuchal hump of male Xiphophorus multilineatus
Fish physiology and biochemistry
2025-07-31
Shubhangini Kataruka,Aushaq B Malla,Shannon R Rainsford,Benjamin William Walters,Rachel A Heuer…
SMARCA5 restricts chromatin accessibility to promote male meiosis and fertility in mammals
Proceedings of the National Academy of Sciences of the United States of America
2025-07-31
Christian Kofoed,Girum Erkalo,Nicholas E S Tay,Xuanjia Ye,Yutong Lin,Tom W Muir
Programmable protein ligation on cell surfaces
Nature
2025-07-31
Zhixin Sun,Jacqueline M Godbe,Alexander Zheleznyak,Brad Manion,Junhao Hu,Julie L Prior,Kathleen…
Advanced quantification pipeline reveals new spatial and temporal tumor characteristics in preclinical multiple myeloma
EJNMMI research
2025-07-31
Nora Lam,J Carlos Angel,Bruce A Buchholz,YoonSeung Lee,Stuart P Weisberg,Brea H Brown,Julia Davis…
Asynchronous aging and turnover of human circulating and tissue-resident memory T cells across sites
Immunity
2025-07-30
Pyung Hun Park,Lauren E Israel,Michael H Alexander,Grace Tartaglia,Harvey G South,Suhao Han,Joseph…
Partial-EMT cell state correlates with single cell pattern of invasion in head and neck SCC keratinocytes
The Journal of pathology
2025-07-30
Qing Luan,Patricia L Clark
Identification of an on-pathway intermediate illuminates the kinetic competition between protein folding and misfolding
Proceedings of the National Academy of Sciences of the United States of America
2025-07-30
Cara M Robertus,Nisha Kannan,David Putnam
A Quantitative Model of Chemotherapeutic Drug Sensitivity as a Function of P-Glycoprotein Expression
Molecules (Basel, Switzerland)
2025-07-30
Aurora Callahan,Aisharja Mojumdar,Mengzhou Hu,Amber Wang,Alijah A Griffith,Nicholas Huang,Xien Yu…
The phosphatases TCPTP, PTPN22, and SHP1 play unique roles in T cell phosphotyrosine maintenance and feedback regulation of the TCR
Scientific reports
2025-07-30
Sukjin S Jang,Korak Kumar Ray,David G Lynall,Kenneth L Shepard,Colin Nuckolls,Ruben L Gonzalez
RNA adapts its flexibility to efficiently fold and resist unfolding
Nucleic acids research
2025-07-30
John F Tuddenham,Masashi Fujita,Emily Lee,Nivedita Nimmagadda,Anthony Khairallah,Claire Harbison…
Single-cell transcriptomic landscape of the neuroimmune compartment in amyotrophic lateral sclerosis brain and spinal cord
Acta neuropathologica
2025-07-29
Jennifer K Bailey,Satoru Horiya,Mahesh Neralkar,Viktor Horvath,Kosuke Nakamoto,J Sebastian Temme…
In Vitro Selection of Cyclized, Glycosylated Peptide Antigens That Tightly Bind HIV High Mannose Patch Antibodies
ACS central science
2025-07-29
Cassidy E Hagan,Valerie M Sheehan,Charles M Rezanka,Meijie A Li,Laura Martínez-Escardó,Kirsteen J…
Apoptotic cells promote circulating tumor cell survival and metastasis
Communications biology
2025-07-29
Shubhangi Agarwal,Deepti Upadhyay,Jinny Sun,Emilie Decavel-Bueff,Robert A Bok,Romelyn Delos Santos…
Impact of Metastatic Microenvironment on Physiology and Metabolism of Small Cell Neuroendocrine Prostate Cancer Patient-Derived Xenografts
Cancers
2025-07-29
Hattan A Alharbi,Muhammad Amin,Kh Ahammad Uz Zaman,Wei Zhou,Zhiran Ju,Taifo Mahmud
Tailoring of Prematurely Released Polyketide Intermediates in Piericidin Biosynthesis
Journal of natural products
2025-07-28
Young Woo Park,Dinesh K Deelchand,James M Joers,Anjali Kumar,Alison Bunio Alvear,Amir Moheet…
Neurochemical Profiles of Prefrontal Cortex and Hypothalamus at 3 and 7 T During Controlled Euglycemia: Evaluation in a Cohort With Type 1 Diabetes
NMR in biomedicine
2025-07-28
Ashleigh M Gil,Daniel F Zegarra-Ruiz,Wan-Jung Wu,Kendra Norwood,Adrien Assie,Buck S Samuel,Angela M…
Dietary lipids induce PPARd and BCL6 to repress macrophage IL-23 induction after intestinal injury and LPS exposure
Scientific reports
2025-07-27
Karl Herbine,Ashok R Nayak,Angelica Zamudio-Ochoa,Dmitry Temiakov
Structural basis for promoter recognition and transcription factor binding and release in human mitochondria
Molecular cell
2025-07-25
Reyan Coskun,ZeNan L Chang,Athziri Marcial Rodríguez,Haoxin Liu,Jiye Cheng,Yael Alippe,Michael S…
Effects of the gut microbiota on placental angiogenesis and intrauterine growth in gnotobiotic mice
Proceedings of the National Academy of Sciences of the United States of America
2025-07-25
Sumi Nechat,Melina Shadi,Andrea D Schreier,Nann A Fangue,John P Sundberg,Robert H Rice
An epithelial cell culture model for sturgeon integument responds sensitively to 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure
Scientific reports
2025-07-24
Francesca A Pavlovici,Kevin Singewald,Samuel Kaplan,Eefei Chen,Glenn L Millhauser
Segmental Isotope Labeling of the Prion Protein: Identification of a Key Residue for Copper-Mediated Interdomain Structure
ACS chemical biology
2025-07-24
Katie C Y Lee,Allison L Williams,Anastasia Fujimoto,Mariana Gerschenson,Connor Schuller,Noemi…
PKM2 is a key regulator of cardiac lipid metabolism in mice
Mitochondrion
2025-07-24
Jingyang Shi,Thomas R Hoye
Acid-catalyzed, Three-component, Spontaneous Cascades of 1,3-Butadiynyl Propargylic Alcohols as a Route to Phthalan Derivatives
ACS catalysis
2025-07-24
Zhanying Feng,Xi Chen,Zhana Duren,Jingxue Xin,Hao Miao,Qiuyue Yuan,Yong Wang,Wing Hung Wong
Modeling combinatorial regulation from single-cell multi-omics provides regulatory units underpinning cell type landscape using cRegulon
Genome biology
2025-07-24
Kauser Jabeen,Joveria Farooqi,Lacy M Simons,Judd F Hultquist,Ramon Lorenzo-Redondo,Charlesnika T…
Scheffersomyces spartinae Fungemia among Pediatric Patients, Pakistan, 2020-2024
Emerging infectious diseases
2025-07-24
Rachel Forman-Rubinsky,Angela Paul,Wei Feng,Brent T Schlegel,Daniel A Zuppo,Katarzyna Kedziora…
Cited4a limits cardiomyocyte dedifferentiation and proliferation during zebrafish heart regeneration
Development (Cambridge, England)
2025-07-23
Amanda R Tursi,Celine S Lages,Kenneth Quayle,Zachary T Koenig,Rashi Loni,Shruti Eswar,José Cobeña…
Automated descriptive cell type naming in flow and mass cytometry with CytoPheno
Scientific reports
2025-07-23
Kailin Yin,Lin Li,Xiaoyu Luo,Jason Neidleman,Arianna G Cassidy,Yarden Golan,Nida Ozarslan,Christine…
Pregnancy and lactation induce distinct immune responses to COVID-19 booster vaccination and SARS-CoV-2 breakthrough infection
JCI insight
2025-07-22
Eva A Krijnen,Hansol Lee,Yixin Ma,Hong-Hsi Lee,Menno M Schoonheim,Eric C Klawiter,Susie Y Huang
Longitudinal changes in cortical cell body and neurite density in people with multiple sclerosis
Neuroscience
2025-07-22
Yiyan Lin,Eleana Parajón,Qinling Yuan,Siyu Ye,Guanghui Qin,Yu Deng,Jane Borleis,Ariel Koyfman,Pablo…
Ras-mediated dynamic and biphasic regulation of cell migration
Proceedings of the National Academy of Sciences of the United States of America
2025-07-22
Jane E Lodwick,Rong Shen,Satchal Erramilli,Yuan Xie,Karolina Roganowicz,Simone Ritchey,Anthony A…
Structural insights into the roles of PARP4 and NAD+ binding in the human vault cage
Nature communications
2025-07-21
Karen Dos Santos,Salva R Yurista,Sophia M Mirrione,David O Guarin Bedoya,Samuel R Calos,Ivan Luptak…
Hyperpolarized [1-13 C] pyruvate MRSI reveals a diet-dependent metabolic shift in ZSF1 rats
Journal of magnetic resonance open
2025-07-21
Jaigeeth Deveryshetty,Ayush Mistry,Sushil Pangeni,Mohamed Ghoneim,Monica Tokmina-Lukaszewska,Steven…
Mechanism of Rad51 filament formation by Rad52 and Rad55-Rad57 in homologous recombination
Nature communications
2025-07-21
Rachel R Chan,Kaitlin M Landy,Kyle J Gibson,Sachin P Kulkarni,Junjing Deng,Byeongdu Lee,Joseph…
Programming Defects and Cavities into Colloidal Crystals Engineered With DNA
Advanced materials (Deerfield Beach, Fla.)
2025-07-21
Jim Lu Zhang,Yu-Chen Chang,Po-Hsuan Lai,Han-I Yeh,Chen-Wei Tsai,Yu-Lun Huang,Tsung-Yun Liu,I-Chi…
TMEM65 functions as the mitochondrial Na+ /Ca2+ exchanger
Nature cell biology
2025-07-21
Victoire Gouirand,Sean Clancy,Courtney Macon,Jose Valle,Mariela Pauli,Hong-An Truong,Jarish Cohen…
Layilin regulates Treg motility and suppressive capacity in skin
eLife
2025-07-21
Daniel J Nilson,Beate Schwer,Steven C Almo,Stewart Shuman,Agnidipta Ghosh
Structural basis for sensitivity and acquired resistance of fungal cap guanine-N7 methyltransferases to the antifungal antibiotic sinefungin
Nucleic acids research
2025-07-19
Harihar M Mohan,Martin G Fernandez,Camellia Huang,Rita Lin,Jaimie H Ryou,Donald Seyfried,Nikolas…
Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and shape their functional biology
Science advances
2025-07-18
Jessica M Porter,Kaitlin R Hulce,Mackenzi S Oswald,Kevin Busuttil,Shanan N Emmanuel,Antonette…
Mechanisms of AAV neutralization by human alpha-defensins
PLoS pathogens
2025-07-18
Moritz Berger,Hector Garcia-Moreno,Mónica Ferreira,Jeannette Hubener-Schmid,Tamara Schaprian…
Progression of biological markers in spinocerebellar ataxia type 3: longitudinal analysis of prospective data from the ESMI cohort
The Lancet regional health. Europe
2025-07-18
Mina Adnani,Sung-Hyeok Hong,Susana Galli,Akanksha Mahajan,Congyi Lu,Nouran Abualsaud,Tyler Biermann…
Targeted CRISPR approach reveals an essential role for neuropeptide Y receptor Y5 in Ewing sarcoma extrapulmonary metastasis
Oncogene
2025-07-17
Hiroaki Ayabe,Erica A K DePasquale,Surya P Amarachintha,Reena Mourya,Wenqi Li,Shreya Nalluri,Sejal…
Cellular crosstalk mediated by TGF-β drives epithelial-mesenchymal transition in patient-derived multi-compartment biliary organoids
Nature communications
2025-07-17
Hanne Laakso,Lin Wu,Sara Ponticorvo,Raimo A Salo,Jaakko Paasonen,Ekaterina Paasonen,Mikko Kettunen…
Simultaneous zero echo time fMRI of rat brain and spinal cord
Magnetic resonance in medicine
2025-07-17
Ya'el Courtney,Maria K Lehtinen
Apocrine secretion by the choroid plexus
Fluids and barriers of the CNS
2025-07-16
Anand Jacob,Alaina H Willet,Maya G Igarashi,Mustapha El Hariri El Nokab,Lesley A Turner,Abdulrahman…
α-glucan remodeling by GH13-domain enzymes shapes fungal cell wall architecture
Proceedings of the National Academy of Sciences of the United States of America
2025-07-16
Jose M Adrover,Xiao Han,Lijuan Sun,Takeo Fujii,Nicole Sivetz,Juliane Daßler-Plenker,Clary Evans…
Neutrophils drive vascular occlusion, tumour necrosis and metastasis
Nature
2025-07-16
Zhen Zhang,Chunrong Li,Nina J Hawkins,Ramesh Mudududdla,Yiming Nie,Peng-Kai Liu,Penghsuan Huang…
Development of Potent and Selective RIPK1 Degraders Targeting Its Nonenzymatic Function for Cancer Treatment
Journal of medicinal chemistry
2025-07-16
Jennifer H McDaniel,Vaidehi Patel,Nathan D Olson,Hua-Jun He,Zhiyong He,Kenneth D Cole,Alexander A…
Development and extensive sequencing of a broadly-consented Genome in a Bottle matched tumor-normal pair
Scientific data
2025-07-16
Andrew M Crawford,David Z Zee,Qiaoling Jin,Aaron Sue,Niharika Sinha,Soo Hyun Ahn,Thomas V O…
AutoSpect: an all-in-one software solution for automated processing of LA-ICP-TOF-MS datasets
Journal of analytical atomic spectrometry
2025-07-14
Tatsuaki Kurosaki,Hana Cho,Elizabeth T Abshire,Christoph Pröschel,Shuhei Mitsutomi,Hanae Sato,Eric…
FMRP drives mRNP targets into translationally silenced complexes
Molecular cell
2025-07-11
Zoe A Figueroa,Jose L Martin,Arzu Ulu,William Agnew-Svoboda,Teresa Ubina,Martin M Riccomagno,Todd A…
Diverse Subpopulations of Reactive Astrocytes Following Chronic Toxoplasma Infection
Glia
2025-07-10
Tanvi M Bhide,Garrett J Musil,Wade Shipley,Emerson Hall,Alex J Guseman,Andrea R Tao,Julia M Stauber
Precision dendritic-supramolecular glycan assemblies for probing multivalent lectin interactions
Chemical science
2025-07-10
Victoria Ektnitphong,Beatriz R S Dias,Priscila C Campos,Michael U Shiloh
An alveolus lung-on-a-chip model of Mycobacterium fortuitum lung infection
Disease models & mechanisms
2025-07-10
Bose Muthu Ramalingam,John D Sears,Kacey M Talbot,Yuan-Wei Norman Su,Scott Houliston,Mohammed Anwar…
Identification of Direct-Acting nsP2 Helicase Inhibitors with Antialphaviral Activity
Journal of medicinal chemistry
2025-07-09
Ed Zandro M Taroc,Enrico Amato,Alexis M Semon,Nikki Dolphin,Briane Beck,Sophie Belin,Yannick…
Shared Lineage, Distinct Outcomes: Yap and Taz Loss Differentially Impact Schwann and Olfactory Ensheathing Cell Development Without Disrupting GnRH-1 Migration
Glia
2025-07-09
Jiayu Zhang,Elizabeth C Chavez,Melina Winkler,Jianche Liu,Sebastian Carver,Aaron E Lin,Abhishek…
Amino acid changes in two viral proteins drive attenuation of the yellow fever 17D vaccine
Nature microbiology
2025-07-08
Qing Lou,Hongcheng Fan,Yang Liu,Jeff F Miller,Yu Huang,Z Hong Zhou
Curvature Generation and Engineering Principles from Shewanella oneidensis Multi-flagellin Flagellum
ACS nano
2025-07-08
Nisansala Vithanage,Rifat Hasan Apurba,Hamza Enesi Ozomarisi,Carson J Bair,Eve L Sugg,Victor K…
SARS-CoV-2 Omicron Variant Spike Glycoprotein Mutation Q954H Enhances Fusion Core Stability
ACS chemical biology
2025-07-07
Joshua Peter,Kaejaren C N Caldwell,Lucas McClain,Jason Tchieu,Ashley E Ross,Yu Luo
Inhibition of PTPRS function does not affect the survival or regeneration of dopaminergic neurons but alters synaptic function in the nigrostriatal pathway
Neurobiology of disease
2025-07-07
Mark T Miedel,Mark E Schurdak,Andrew M Stern,Alejandro Soto-Gutierrez,Eric von Strobl,Jaideep…
Integrated Patient Digital and Biomimetic Twins for Precision Medicine: A Perspective
Seminars in liver disease
2025-07-04
Valerie J Sydnor,Joëlle Bagautdinova,Bart Larsen,Michael J Arcaro,Deanna M Barch,Dani S Bassett…
Human thalamocortical structural connectivity develops in line with a hierarchical axis of cortical plasticity
Nature neuroscience
2025-07-04