Daniel O'Reilly,Raymond C Furgal,Vella M Ross,Eric Luu,Katherine Y Gross,Vignesh Hariharan,Ashley…
Presence of phosphodiester backbone, but not nucleobases, in the guide's 3' terminal region is necessary for RISC loading and target cleavage in vitro and in vivo
Nucleic acids research
2026-01-12
Joshua M Jarodsky,Janette B Myers,Steve L Reichow
Reversible lipid-mediated pH-gating of connexin-46/50 by cryo-EM
Nature communications
2026-01-12
Xinlu Han,Jianliang Shen,Junrong Yan,Rahul Tacke,Weiwei Dai,Qingqing Mao,Heineken Queen Daguplo…
Impaired nitrogenous waste clearance promotes hepatocellular carcinoma
Science advances
2026-01-09
Jiansi Gao,Marius Brusselmans,Luiz M Carvalho,Marc A Suchard,Guy Baele,Frederick A Matsen
Biological causes and impacts of rugged tree landscapes in phylodynamic inference
Proceedings of the National Academy of Sciences of the United States of America
2026-01-09
Biyue Zhu,Zhenhua Liu,Richard Van,Huizhe Wang,Shi Kuang,Yuntao Jia,Erick Calderon Leon,Fan Yang…
Highly sensitive chemiluminescence imaging of misfolded proteins in neurodegenerative models
Proceedings of the National Academy of Sciences of the United States of America
2026-01-09
Jin Hwan Park,Emily N Kennedy,Sarvind Tripathi,Avery B Romp,Seth M Rubin,Robert B Bourret,Fitnat H…
Distinct PlzC mechanisms integrate chemotaxis and c-di-GMP signaling to regulate Vibrio cholerae motility and biofilm formation
Proceedings of the National Academy of Sciences of the United States of America
2026-01-09
Naemeh Pourshafie,Desi C Alexander,Hong Xu,Kechun Yang,Greg Donahue,Xue Lei,Shuo Zhang,Oksana…
ACSS2 upregulation enhances neuronal resilience to aging and tau-associated neurodegeneration
Proceedings of the National Academy of Sciences of the United States of America
2026-01-09
Ashwini Sri Hari,Alexandria M Chan,Audrey Scholl,Aidan Mulligan,Janint Camacho,Ireland Rose Kearns…
Multiomic Analyses Reveal Brainstem Metabolic Changes in a Mouse Model of Dravet Syndrome
Cells
2026-01-09
Hannah Doyle,Nicole C R McLaughlin,Sarah L Garnaat,Theresa M Desrochers
Cognitive sequences in obsessive-compulsive disorder are supported by frontal cortex ramping activity
Imaging neuroscience (Cambridge, Mass.)
2026-01-09
Darby Steinman,Alyssa P Petersen,Yasmi Chibber,Caleb Crawford,Pranshu Tyagi,Hannah C Zierden
Vaginal bacteria-derived extracellular vesicles diffuse through human cervicovaginal mucus to enable microbe-host signaling
NPJ biofilms and microbiomes
2026-01-09
Hugo Calligaro,Brian Khov,Keun-Young Kim,Hiep Le,Mark Ellisman,Satchidananda Panda
Neuropsin-expressing cells in the retina affect melanopsin expression and response to light in mice
Scientific reports
2026-01-08
Joseph T Colonel,Jacqueline Becker,Lili Chan,Cara Faherty,Tielman van Vleck,Laura Curtis,Juan…
Acoustic Analysis of Primary Care Patient-provider Conversations to Screen for Cognitive Impairment
medRxiv : the preprint server for health sciences
2026-01-08
Karly A Cody,Andrzej Sokołowski,Emily Johns,Lucah Medina Guerra,Joseph R Winer,Christina B Young…
Characterizing amyloid and tau positron emission tomography-based stages across the clinical continuum
Alzheimer's & dementia : the journal of the Alzheimer's Association
2026-01-08
Jessica L Norris,Lindsey O Rogers,Grace Young,Kara G Pytko,Rachel L Dannenberg,Samuel Perreault…
PCNA encircling primer/template junctions is eliminated by exchange of RPA for Rad51: implications for the interplay between human DNA damage tolerance pathways
Nucleic acids research
2026-01-07
Priyanka Parmar,Burcu Karadal-Ferrena,Suryansh Shukla,Andrew Miller,Chenxin Zhang,Cien Huang…
Racial disparity in pro-metastatic tumor microenvironment in treatment naïve breast cancer
NPJ breast cancer
2026-01-06
Nicole Welch,Pugazhendhi Kannan,Gangarao Davuluri,Annette Bellar,Amy H Attaway,Saurabh Mishra…
Hyaluronan 35 prevents endotoxin-mediated dysregulated skeletal muscle proteostasis during ethanol exposure
American journal of physiology. Endocrinology and metabolism
2026-01-06
Derrick Thomas,Brittany M Hufft-Martinez,Zarna Lalwani,Vi Pham,Mary Elmeniawi,An J Tran,Jianming Xu…
Loss of Twist1 leads to disruption of ciliary length, endocytic vesicle dynamics, and cell-cell junctions during neural tube formation
Developmental dynamics : an official publication of the American Association of Anatomists
2026-01-06
Satoki Shibata,Matthew Y Wang,Tsuyoshi Imasaki,Hideki Shigematsu,Diego Ugarte La Torre,Yuanyuan Wei…
Structural analysis of a motor with increased mechanical output reveals new transitions in kinesin microtubule motility
Scientific reports
2026-01-06
Anushka C Wickramaratne,Emil Sjulstok Rasmussen,Yogarany Chelliah,Fabian Schuhmann,Ilia A Solov'yov…
Structure of European robin cryptochrome 1 reveals a role in circadian rhythms, not magnetoreception
iScience
2026-01-05
Anna J Sigmon,Tatiana N Laremore,Hemant Yennawar,Gracie Clare Guerin,Brendan Pelletier,Samreen…
A Green, Facile Method for Selective α‑Bromination of Flavanones
ACS omega
2026-01-05
Naresh Doni Jayavelu,Hady Samaha,Sonia Tandon Wimalasena,Annmarie Hoch,Jeremy P Gygi,Gisela…
Machine learning models predict long COVID outcomes based on baseline clinical and immunologic factors
Communications medicine
2026-01-03
Karishma Bisht,Daniel R Weilandt,Caitlin H Lamb,Elizaveta Elshina,Cameron Myhrvold,Aartjan J W Te…
Febrile temperature activates the innate immune response by promoting aberrant influenza A virus RNA synthesis
Science advances
2026-01-02
Masayoshi Higuchi,August F Williams,Anna E Stuhlfire,Ariel H Nguyen,David A G Gervasio,Claire E…
FSP1 and histone deacetylases suppress cancer persister cell ferroptosis
Science advances
2026-01-02
Haiyan Lu,Yuan Liu,Hung-Yu Chiang,Hua Zhang,Xudong Shi,Lingjun Li
Exploring the interplay between protein conformational changes and phosphorylation in a pancreatic cancer cell and stellate cell coculture system
Proceedings of the National Academy of Sciences of the United States of America
2026-01-02
Sunnyjoy Dupuis,Jordan L Chastain,Genevieve Han,Victor Zhong,Sean D Gallaher,Carrie D Nicora,Samuel…
Acclimation to high and low diurnal light is flexible in Chlamydomonas reinhardtii
Proceedings of the National Academy of Sciences of the United States of America
2026-01-02
Subhajit Ghosh,Nicholas Sesing,Zahra Ebrahim Nataj,Tina Salguero,Sergey Rumyantsev,Roger K Lake…
A quieter state of charge and ultra-low-noise of the collective current in quasi-1D charge-density-wave nanowires
Nature communications
2025-12-31
Michaela Medina,Ya-Ting Chang,Hamidreza Rahmani,Mark Frank,Zidan Khan,Daniel Fuentes,Frederick A…
Surface Morphometrics reveals local membrane thickness variation in organellar subcompartments
The Journal of cell biology
2025-12-31
Roberta S Dos Reis,Lauren A Ignatz,Sathish Selvam,Marc C E Wagner,Sara Gianella,Antoine Chaillon…
Microglial reactivity and nodule formation are associated with Synaptodendritic damage in the brains of people with HIV-1
Brain pathology (Zurich, Switzerland)
2025-12-30
Scotty G McKay,Yongsheng Chen,E Mark Haacke,Yang Xuan,Aimee F Luat,Csaba Juhász
Clinical Validation of a Fast MRI Method to Evaluate Brain Vascular and Parenchymal Abnormalities in Sturge-Weber Syndrome
Journal of magnetic resonance imaging : JMRI
2025-12-30
Juan Hernandez-Bird,Bixi He,Leah M VanOtterloo,Elizabeth B Billings,Wenwen Huo,Gabriella I C…
Resistance, heteroresistance, and fitness costs drive colistin treatment failure during Acinetobacter baumannii pneumonia
Proceedings of the National Academy of Sciences of the United States of America
2025-12-29
Shweta S Dipali,Aubrey Converse,Madison Q Gowett,Pratik Kamat,Emily J Zaniker,Abigail Fennell…
Self-Organizing Ovarian Somatic Organoids Preserve Cellular Heterogeneity and Reveal Cellular Contributions to Ovarian Aging
Aging cell
2025-12-29
Tony W Wilson,Mikki Schantell,Sarah M Dietz,Samantha H Penhale,Kellen M McDonald,Kyla R De Luca…
Neural oscillations serving abstract reasoning are differentially associated with inflammatory markers in people with HIV
Brain, behavior, and immunity
2025-12-26
Yuancheng Jiang,Yohan Jun,Qiang Liu,Wen Zhong,Yogesh Rathi,Hua Guo,Berkin Bilgic
Multishot Dual Polarity GRAPPA: Robust Nyquist Ghost Correction for Multishot EPI
Magnetic resonance in medicine
2025-12-26
Guitao Bai,Tangliang Shen,MohammadHossein Shabahang,Shumin Bao,Shuquan Fan,Hongshuai Lv,Lei Li
Divergent Enzymatic Synthesis of a Comprehensive Type‑1 Glycan Determinant Library
ACS catalysis
2025-12-25
Whitney Nicole Bergman,Marcelo Carlos Sousa
A fluorescent reporter and single-turnover kinetics reveal insight into BAM complex function
Proceedings of the National Academy of Sciences of the United States of America
2025-12-24
Brianna Fernandez,Victor J Passanisi,Humza M Ashraf,Sabrina L Spencer
Single-cell RNA sequencing reveals a quiescence-senescence continuum and distinct senotypes following chemotherapy
Nature communications
2025-12-23
Stephanie Stransky,Sarah Graff,Kai Mao,Derek M Huffman,Sofiya Milman,Nir Barzilai,Simone Sidoli
Preliminary Evidence for Increased Histone Succinylation as a Potential Epigenetic Marker for Longevity
Aging cell
2025-12-23
Somayeh Zeinalilathori,Ryan W Russell,Jean L Ross,Shannon Modla,Jeffrey L Caplan,Tatyana Polenova…
Structure of the disulfide-rich modules of a striking tandem repeat protein, avian cysteine-rich eggshell membrane protein
Protein science : a publication of the Protein Society
2025-12-23
Ravi Shankar Palani,Christopher G Williams,Dev Thacker,Robert Silvers,Fang Qian,Paul H Weinreb…
Aducanumab binding to Aβ1-42 fibrils alters dynamics of the N-terminal tail while preserving the fibril core
Proceedings of the National Academy of Sciences of the United States of America
2025-12-22
Preethi Korangath,Hayden Carlton,Toby Sanders,Olivia C Sehl,Suqi Ke,Abdul Rahman Mohtasebzadeh…
Nanoparticle retention enables non-invasive detection of metastases by magnetic particle imaging in murine breast cancer models
Theranostics
2025-12-22
Jenna K Schmidt,Ann M Mitzey,Logan T Keding,Sarah A Shaw,Lewis Renshall,Frances Beards,Mona H Al…
Targeted nanoparticles for placenta-specific drug delivery in pregnant rhesus macaques
Theranostics
2025-12-22
John Mutersbaugh,Wan-Chun Su,Anjana Bhat,Amir Gandjbakhche
Deep Learning Approaches for Classifying Children With and Without Autism Spectrum Disorder Using Inertial Measurement Unit Hand Tracking Data: Comparative Study
JMIR medical informatics
2025-12-22
Viola Rieke,Allison Payne,Robb Merrill,J Rock Hadley,Henrik Odéen,Michelle Kline,Matthew S…
Design and evaluation of a magnetic resonance-guided focused ultrasound system for the treatment of cervical spine pain
Medical physics
2025-12-21
Erica Braverman,Mengtao Qin,Elisabet Ampudia-Mesias,Herbert Tres Schuler,Harrison Brown,Lukas…
AMPK agonism optimizes the in vivo activation and antileukemic efficacy of chimeric antigen receptor T cells
Journal for immunotherapy of cancer
2025-12-21
Jessica Burnier,Clement Gallay,Kevin E Bruce,Elisabet Bjånes,Louise Martin,Kin Ki Jim,Ho-Ching…
Pneumococcal S protein coordinates cell wall modification and repair to resist host antimicrobials
Nature microbiology
2025-12-19
Kristen Springer,Heun Soh,Raquel Paz Zavala,Nissi Varghese,Cathleen Lutz,Aamir R Zuberi,Alexander C…
Mislocalization of KCNQ2 Channels as a Pathogenic Mechanism in KCNQ2 Developmental and Epileptic Encephalopathy
The Journal of neuroscience : the official journal of the Society for Neuroscience
2025-12-19
Joshua M Mesfin,Alexander Chen,Quincy P Lyons,Michael B Nguyen,Maria L Karkanitsa,Justin Yu,Van K…
Infusible Extracellular Matrix Biomaterial Enhances Cell-Specific Pro-Repair Responses Following Acute Myocardial Infarction
Advanced healthcare materials
2025-12-19
Yu Zhao,Ruoxin Li,Pingchuan Liu,Jialiang Wang,Yanru Cui,Yufei Ma,Zeyu Cao,Meng Cui,Sijin Luozhong…
Low reactogenicity and high tumour antigen expression from mRNA-LNPs with membrane-destabilizing zwitterionic lipids
Nature biomedical engineering
2025-12-18
Xiaohan Kuang,Yunchao Lance Liu,Xiaobo Lin,Jesse Spencer-Smith,Tyler Derr,Yinghao Wu,Hans Bitter…
Superwater as a generative AI framework to predict water molecule positions on protein structures
Communications chemistry
2025-12-18
Hélène Tonnelé,Denghui Chen,Felipe Morillo,Jorge Garcia-Calleja,Apurva S Chitre,Benjamin B Johnson…
Genetic architecture and mechanisms of host-microbiome interactions from a multi-cohort analysis of outbred laboratory rats
Nature communications
2025-12-18
Tingting Li,Peilin Zhu,Jialing Wang,Tao Zhang,Joseph Adams,Fei Tu,Chloe Garbe,Xiaojin Zhang,Li Liu…
Heme drives cardiac endothelial senescence in sepsis via STING activation
Cell death & disease
2025-12-18
Kelsey C Muir,Christopher Stone,Riya Reddy,Meghamsh Kanuparthy,Jad Hamze,Dwight D Harris,M Ruhul…
Sotagliflozin Enhances Left Ventricular Function and Myocardial Perfusion in Chronic Myocardial Ischemia Through Metabolic and Redox Remodeling
Arteriosclerosis, thrombosis, and vascular biology
2025-12-18
Richa Singhal,Ilaria Ferrari,Robert E Brainard,Kenneth R Brittian,Julia Chariker,Helen E Collins…
Temporal Dynamics in Murine Cardiac Transcriptome Following Myocardial Infarction
Circulation research
2025-12-18
Chatipat Lorpaiboon,Jonathan Weare,Aaron R Dinner
An Exact Multiple-Time-Step Variational Formulation for the Committor and the Transition Rate
The journal of physical chemistry. B
2025-12-17
Zhenyu Zhang,Isabel Uribe,Kaitlin A Davis,Robert L McPherson,Gloria P Larson,Mohsen Badiee,Vy Tran…
Global remodeling of ADP-ribosylation by PARP1 suppresses influenza A virus infection
Nature communications
2025-12-17
Xuwen Liu,Enming J Su,Alyssa Dreffs,John P Gillies,Madeline Merlino,Lu Gao,Julian S Peregoff,Cheng…
Occludin acts as a dynein adaptor regulating permeability and collateral angiogenesis
Proceedings of the National Academy of Sciences of the United States of America
2025-12-16
Daniel L Aldridge,Zachary Lanzar,Anthony T Phan,David A Christian,Ryan D Pardy,Booki Min,Ross Kedl…
IL-27 limits HSPC differentiation during infection and protects from stem cell exhaustion
eLife
2025-12-15
Samantha L Goldschmid,Holly L Hutchinson,Trevor C Sherwood,Candice L Joe,Eric R Welin,Tomislav Rovis
Engaging Tertiary Benzylic Radicals in Metallaphotoredox Catalysis: A Modular Approach to Access Diaryl Quaternary Centers
Angewandte Chemie (International ed. in English)
2025-12-15
Malika Aid,Valentin Boero-Teyssier,Katherine McMahan,Rammy Dong,Michael Doyle,Nazim Belabbaci,Erica…
Long COVID involves activation of proinflammatory and immune exhaustion pathways
Nature immunology
2025-12-13
Aditya Banerjee,Sophie Pickelner,Faith Smith,Livia M A Tenuta,Randy B Stockbridge
Fluoride triggers lysis in Streptococcus mutans by inhibition of the Clp protease complex, leading to an unabated competence cascade
Proceedings of the National Academy of Sciences of the United States of America
2025-12-11
Hiroki Yamagishi,David W Small,Richmond Sarpong
Unified Total Synthesis of C2 -Symmetric Bis(cyclotryptamine) Alkaloids Utilizing a Single-Atom Insertion/Deletion Strategy
Journal of the American Chemical Society
2025-12-11
Penghsuan Huang,Joseph Sardina,Haiyan Lu,Gaspar Bruner-Montero,Cameron R Currie,Lingjun Li
Proteome-Wide Analysis and Surface Protein Isolation for Secretome Characterization Reveal Insights into the Biology of the Leaf-Cutter Ant Acromyrmex echinatior
Analytical chemistry
2025-12-11
Jennifer Gundrum,S Tabita Ramirez-Puebla,Jessica L Mark Welch,Gary G Borisy
Slicing overcomes the bacterial cell wall barrier to fluorescence in situ hybridization
Microbiology spectrum
2025-12-10
Sarah Moe,Christophe Chipot,Benoît Roux
GPU-Accelerated Implementation of Constant-pH Molecular Dynamics in NAMD
Journal of chemical information and modeling
2025-12-09
Anna Potapova,Rino Oguchi,Steffi Jimmy,Christopher R Evans,Kaitlin D Yarrington,James B Winans…
Vibrio cholerae biofilm matrix assembly and growth are shaped by a glutamate-specific TAXI/TRAP protein
Proceedings of the National Academy of Sciences of the United States of America
2025-12-09
Detao Gao,Khuraijam Dhanachandra Singh,Sadashiva Karnik,Tatiana V Byzova,Eugene A Podrez
Structural Insights into Recognition and Translocation of Oxidized Phospholipid by CD36 Using Mass Spectrometry, Molecular Docking, Dynamics, and Metadynamics Simulations
Journal of the American Chemical Society
2025-12-09
Alexander F Lesser,Aura Perez,Chunying Wu,Shuyu Hao,Bernadette Erokwu,Derek Host,Anjum Jafri,Elisha…
Intestinal adaptations increase basolateral intestinal glucose uptake and glycolysis in a mouse model of cystic fibrosis
American journal of physiology. Gastrointestinal and liver physiology
2025-12-09
Shang Ning,Thomas J Maimone
Total Synthesis of Aconicarmisulfonine A, a Sulfonated Diterpene Alkaloid
Journal of the American Chemical Society
2025-12-08
Xianting Hu,Zhi Liu,Yao Li,Yannan You,Kaiye Yue,Yuqiong Liang,Chin-San Loo,Jingting Yu,Matthias…
REV-ERB regulates RORγt+ regulatory T cell specification and function through the Bhlhe40-c-Maf axis
The Journal of experimental medicine
2025-12-08
Aayushi Singh,Francesco Pettini,Beatrice Gianibbi,Sayan Das,Donatella Barisani,Jeffrey A Purslow…
Structure-based Discovery of a Non-competitive FTO Inhibitor Bound to a Cryptic Site at the Domain Interface
Journal of molecular biology
2025-12-07
Rose Z Hill,Jonathan W Nelson,Georgina Gyarmati,Silvia Medrano,Sepenta Shirvan,James A McCormick…
Renal PIEZO2 is an essential regulator of renin
Cell
2025-12-05