Division of Construction and Instruments

ORIP’s Division of Construction and Instruments (DCI) supports research infrastructure in three areas: the S10 Instrumentation Programs (acquisition of state-of-the-art research instruments), the S15 Equipment Program (acquisition of modern research or auxiliary equipment to enhance operations of shared-use biomedical research facilities, formerly under the R24 activity code), and Extramural Construction Programs (construction and modernization of research facilities).

For more information on the S10 and S15 programs, view DCI's fact sheets:

C06 Extramural Construction Programs

S10 Instrumentation Programs

S15 Equipment Program

DCI Funding Opportunities

DCI Awards

New S10 Publications

DCI News and Research Highlights

Magnetic resonance imaging and positron emission tomography merged images of mouse brains with gliomas at Day 1 and Day 4.

Seeing the Invisible: Next-Generation Imaging Instruments Transform Brain Cancer Research

Brain cancer remains difficult to treat for several key reasons, one of which is the inability of drugs to successfully cross the blood–brain barrier (BBB) and modify the immunosuppressive tumor microenvironment (TME).

The process of determining an appropriate lenacapavir dose through analytical measurements, data analysis, and patient-provider targeted discussions.

Decades of ORIP Support Contributed to Lenacapavir Development

In July 2024, one of the most significant recent HIV breakthroughs was announced at the International AIDS Conference: The twice-yearly injectable drug lenacapavir was shown to prevent nearly all HIV infections in clinical trials.

UM Biospecimen Facility. Photo courtesy of UM.

University of Miami Biospecimen Repository: Transforming Precision Medicine Research

The John P. Hussman Institute for Human Genomics at the University of Miami (UM) Miller School of Medicine (MSOM) has transformed its biomedical research infrastructure with a state-of-the-art Biospecimen Facility (Figure 1) capable of storing more than 5 million specimens, substantially expanding its clinical and translational research infrastructure.

ORIP’s C06 Builds a Powerhouse for Preclinical Imaging and Irradiation Research at Wake Forest University School of Medicine

The Preclinical Imaging and Irradiation (PRIMIR) facility at Wake Forest University School of Medicine (WFUSM) is a state-of-the-art center that combines specialized imaging and radiation capabilities at a single location (Figure 1).

Aging Healthier and Living Longer: ORIP’s S10 Programs Helped Advance Multiomics Research on Aging

Aging is a complex, natural process and is the single largest risk factor for nearly all chronic diseases. Beyond observing more wrinkles and grey hairs, or checking bone density and elevated low-density lipoprotein, are there more reliable, comprehensive, and systematic measurements to detect normal aging from diseased aging?

S10 Mass Spectrometers Accelerate Collaborations on Aging and Women’s Health Research

Scientific and health innovations rely on continuous access to cutting-edge technology and instruments. Dr. Birgit Schilling, Professor, Buck Institute for Research on Aging, and Director of the Proteomics Core and Mass Spectrometry Center, knows this better than most.

NMR of bacterial extracellular vesicles reveals pH-driven conformational change of the Salmonella surface protein PagC.

Structural Studies In Situ Show How Bacteria Infect Humans, Leading to Chronic Diseases

Understanding the biological mechanisms that support human health and drive disease is essential for developing preventive and curative therapeutics. Direct structural analyses of proteins in their native environment are even more important.

An illustration of three glowing, capsule-shaped microscopic devices floating in a dark blue environment. Each capsule contains intricate internal structures and emits bright beams of light, giving the impression of motion through a fluid-like space.

Micron-Scale Bioglass Confirmed with S10-Supported Optical Tweezers for Biomedical Research

Biologically based glass (i.e., bioglass) has a longstanding history in health applications. Synthetic bioglass was developed in the late 1960s and has since been used in many ways.¹ This silica-based, biodegradable material is less likely to be rejected by the body than many other materials used for medical implants.

Dr. Eric A. Hoffman (right), Advanced Pulmonary Physiomic Imaging Laboratory (APPIL) Director, and Dr. Jessica C. Sieren (left), APPIL Deputy Director.

Seeing the Invisible: Detecting Early Lung Diseases with Advanced Computed Tomographic Imaging

For decades, physicians have relied on spirometry to detect chronic obstructive pulmonary disease (COPD). However, the global metrics derived from spirometry (a noninvasive breathing test) cannot sense regional lung damage in early disease.

See More News and Research Highlights

New S10 Publications

This list of recent publications is sourced from PubMed and has been curated. For an exhaustive list please visit PubMed.

Author List	Title	Journal Title	Publication Date
Marcella D Baiz,Lan-Nhi Phung,Daniel Pierce,Stephanie J Szarmach,Johanna K Beam,Shawn Healy,Alan…	Genetic Links to Gut Microbiome Variation in the Yellow-Rumped Warbler Hybrid Zone	Molecular ecology	2026-08-13
Cao Son Trinh,Ruben Shrestha,Pengzhi Mao,William C Conner,Andres V Reyes,Sumudu S Karunadasa,Annie…	Mapping the architecture of protein complexes in Arabidopsis using cross-linking mass spectrometry	Proceedings of the National Academy of Sciences of the United States of America	2026-08-12
Shun Li,Na Qiu,Chao Zhou,Andrew Ni,Ping Sun,Jia-Jun Liu,Xin-Lei Huang,Tian-Qing Xiong,Yu-Chi Zhang…	Endothelial miR-15a/16-1 Regulation of SYNE1 Mediates Structural and Functional Recovery after Traumatic Brain Injury	Advanced science (Weinheim, Baden-Wurttemberg, Germany)	2026-08-12
Marco Pipoly,Hayley Chappell,Lyndsey E DuBose,Bryan Madero,Adriana Rivera-Dompenciel,Matthew Sodoma…	Comparison of the Relationships Between Body Size and Cardiorespiratory Fitness With High Frequency Head-Motion Contamination in fMRI	Human brain mapping	2026-08-11
Sang Hee Lee,Jung Min Kim,Joseph Blecha,Robert R Flavell,Michael A Ohliger,Joanne Engel,Youngho Seo…	Chemoenzymatic Radiosynthesis of a Gluconate Transporter-Targeted In Vivo Bacterial Sensor From Clinical [¹⁸F]FDG	Angewandte Chemie (International ed. in English)	2026-08-11