Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2015
Study Type/Review: vaccine
NPRC/Institute: NIAID, Vaccine Research Center
Keywords: antibodies, vaccines, viral infection, virology
Summary of Study: This study developed DNA expression vectors and soluble protein immunogens that elicited cross-reactive neutralizing antibodies against known, circulating strains of MERS-CoV.
References: doi: 10.1038/ncomms8712; PMID: 26218507
Contact Info: Wang L, et al.; correspondence to Wing-Pui Kong (vog.hin.diain@gnokw)
URL: https://pubmed.ncbi.nlm.nih.gov/26218507/
NHP Species: rhesus macaques
Year Published: 2015
Study Type/Review: vaccine
NPRC/Institute: NIAID, Vaccine Research Center
Keywords: antibodies, vaccines, viral infection, virology
Summary of Study: This study developed DNA expression vectors and soluble protein immunogens that elicited cross-reactive neutralizing antibodies against known, circulating strains of MERS-CoV.
References: doi: 10.1038/ncomms8712; PMID: 26218507
Contact Info: Wang L, et al.; correspondence to Wing-Pui Kong (vog.hin.diain@gnokw)
URL: https://pubmed.ncbi.nlm.nih.gov/26218507/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2015
Study Type/Review:
NPRC/Institute: NIAID, Laboratory of Virology
Keywords: animal models, coronavirus, emerging viruses, MERS-CoV, public health
Summary of Study: This article forms part of a symposium in Antiviral Research on “From SARS to MERS: research on highly pathogenic human coronaviruses.â€
References: doi: 10.1016/j.antiviral.2015.07.005; PMID: 26192750
Contact Info: Van Doremalen N and Munster VJ; correspondence to Vincent Munster ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/26192750/
NHP Species: rhesus macaques
Year Published: 2015
Study Type/Review:
NPRC/Institute: NIAID, Laboratory of Virology
Keywords: animal models, coronavirus, emerging viruses, MERS-CoV, public health
Summary of Study: This article forms part of a symposium in Antiviral Research on “From SARS to MERS: research on highly pathogenic human coronaviruses.â€
References: doi: 10.1016/j.antiviral.2015.07.005; PMID: 26192750
Contact Info: Van Doremalen N and Munster VJ; correspondence to Vincent Munster ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/26192750/
Coronavirus Investigated: MERS-CoV
NHP Species: marmosets
Year Published: 2015
Study Type/Review: vaccine
NPRC/Institute: HKU Med, ILAS
Keywords: Kaletra, MERS, animal, common marmoset, coronavirus, interferon, lopinavir, mycophenolate, primate, treatment
Summary of Study: This study assessed three repurposed drugs with potent in vitro anti-MERS-CoV activity (mycophenolate mofetil [MMF], lopinavir/ritonavir, and interferon-β1b) in common marmosets with severe disease resembling MERS in humans.
References: doi: 10.1093/infdis/jiv392; PMID: 26198719
Contact Info: Chan JF, et al.; correspondence to Kwok-Yung Yuen ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/26198719/
NHP Species: marmosets
Year Published: 2015
Study Type/Review: vaccine
NPRC/Institute: HKU Med, ILAS
Keywords: Kaletra, MERS, animal, common marmoset, coronavirus, interferon, lopinavir, mycophenolate, primate, treatment
Summary of Study: This study assessed three repurposed drugs with potent in vitro anti-MERS-CoV activity (mycophenolate mofetil [MMF], lopinavir/ritonavir, and interferon-β1b) in common marmosets with severe disease resembling MERS in humans.
References: doi: 10.1093/infdis/jiv392; PMID: 26198719
Contact Info: Chan JF, et al.; correspondence to Kwok-Yung Yuen ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/26198719/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2015
Study Type/Review:
NPRC/Institute: City University of New York
Keywords: oligoadenylate synthetase 1, SARS-CoV, primates, convergent polymorphism
Summary of Study: This case investigated the evolution of OAS1 in primates by characterizing intra-specific variation in four species commonly used as models in infectious disease research: the rhesus macaque, the cynomolgus macaque, the olive baboon, and the Guinea baboon.
References: doi: 10.1007/s00251-015-0855-0; PMID: 26156123
Contact Info: Fish I and Boissinot S; correspondence to Stéphane Boissinot ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/26156123/
NHP Species: rhesus macaques
Year Published: 2015
Study Type/Review:
NPRC/Institute: City University of New York
Keywords: oligoadenylate synthetase 1, SARS-CoV, primates, convergent polymorphism
Summary of Study: This case investigated the evolution of OAS1 in primates by characterizing intra-specific variation in four species commonly used as models in infectious disease research: the rhesus macaque, the cynomolgus macaque, the olive baboon, and the Guinea baboon.
References: doi: 10.1007/s00251-015-0855-0; PMID: 26156123
Contact Info: Fish I and Boissinot S; correspondence to Stéphane Boissinot ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/26156123/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques, marmosets
Year Published: 2015
Study Type/Review:
NPRC/Institute: NIAID, Emerging Viral Pathogens Section
Keywords: animal model, coronavirus, MERS, MERS-CoV, MERS, nonhuman primate
Summary of Study: This data suggest that common marmosets developed a mild to moderate non-lethal respiratory disease, which was quantifiable by computed tomography (CT), with limited other clinical signs.
References: doi: 10.1016/j.virol.2015.07.013; PMID: 26342468
Contact Info: Johnson RF, et al.; correspondence to Reef F. Johnson ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/26342468/
NHP Species: rhesus macaques, marmosets
Year Published: 2015
Study Type/Review:
NPRC/Institute: NIAID, Emerging Viral Pathogens Section
Keywords: animal model, coronavirus, MERS, MERS-CoV, MERS, nonhuman primate
Summary of Study: This data suggest that common marmosets developed a mild to moderate non-lethal respiratory disease, which was quantifiable by computed tomography (CT), with limited other clinical signs.
References: doi: 10.1016/j.virol.2015.07.013; PMID: 26342468
Contact Info: Johnson RF, et al.; correspondence to Reef F. Johnson ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/26342468/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2015
Study Type/Review:
NPRC/Institute: NIAID, Integrated Research Facility, Division of Clinical Research
Keywords: [18F]-FDG-PET, MERS-CoV, animal models, kinetic modeling
Summary of Study: This study extends the use of kinetic modeling of [18F]-FDG uptake during lung inflammation to host immune response after MERS-CoV exposure in rhesus macaques. Compared with SUVs, K i computation increases signal-to-noise ratio of PET data that results in improved accuracy of measurement and method sensitivity.
References: doi: 10.1186/s13550-015-0143-x; PMID: 26573211
Contact Info: Chefer S, et al.; correspondence to S. Chefer ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/26573211/
NHP Species: rhesus macaques
Year Published: 2015
Study Type/Review:
NPRC/Institute: NIAID, Integrated Research Facility, Division of Clinical Research
Keywords: [18F]-FDG-PET, MERS-CoV, animal models, kinetic modeling
Summary of Study: This study extends the use of kinetic modeling of [18F]-FDG uptake during lung inflammation to host immune response after MERS-CoV exposure in rhesus macaques. Compared with SUVs, K i computation increases signal-to-noise ratio of PET data that results in improved accuracy of measurement and method sensitivity.
References: doi: 10.1186/s13550-015-0143-x; PMID: 26573211
Contact Info: Chefer S, et al.; correspondence to S. Chefer ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/26573211/
Coronavirus Investigated: SARS-CoV, MERS-CoV
NHP Species: multiple species
Year Published: 2015
Study Type/Review:
NPRC/Institute: NIAID
Keywords: animal models, coronaviruses, MERS-CoV, receptor, SARS-CoV
Summary of Study: The authors reviewed a variety of animal models, including NHPs. Individual NHP studies are represented elsewhere in this document.
References: doi: 10.1016/j.virol.2015.02.030; PMID: 25791336
Contact Info: Sutton TC and Subbaro K; correspondence to Kanta Subbarao ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/25791336/
NHP Species: multiple species
Year Published: 2015
Study Type/Review:
NPRC/Institute: NIAID
Keywords: animal models, coronaviruses, MERS-CoV, receptor, SARS-CoV
Summary of Study: The authors reviewed a variety of animal models, including NHPs. Individual NHP studies are represented elsewhere in this document.
References: doi: 10.1016/j.virol.2015.02.030; PMID: 25791336
Contact Info: Sutton TC and Subbaro K; correspondence to Kanta Subbarao ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/25791336/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2014
Study Type/Review:
NPRC/Institute: Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing
Keywords: MERS, animal model, coronavirus, pathology, rhesus monkey
Summary of Study: This study developed rhesus macaques as a model for MERS-CoV using intratracheal inoculation.
References: doi: 10.1093/infdis/jit590; PMID: 24218506; PMCID: PMC7107340
Contact Info: Yao Y, et al.; correspondence Chuan Qin ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/24218506/
NHP Species: rhesus macaques
Year Published: 2014
Study Type/Review:
NPRC/Institute: Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing
Keywords: MERS, animal model, coronavirus, pathology, rhesus monkey
Summary of Study: This study developed rhesus macaques as a model for MERS-CoV using intratracheal inoculation.
References: doi: 10.1093/infdis/jit590; PMID: 24218506; PMCID: PMC7107340
Contact Info: Yao Y, et al.; correspondence Chuan Qin ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/24218506/
Coronavirus Investigated: SARS-CoV
NHP Species: african green monkeys
Year Published: 2014
Study Type/Review:
NPRC/Institute: Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands
Keywords: SARS coronavirus, animal model, influenza, respiratory disease
Summary of Study: In this review, SARS-CoV infection is described in nonhuman primates (cynomolgus macaques and African green monkeys [AGMs]) and carnivores (ferrets and cats). This review focuses on the pathology and pathogenesis of SARS-CoV and influenza A virus infections, not only comparing the two viruses, but also comparing the pathology of these virus infections in experimental animals to that in man.
References: doi: 10.1016/j.jcpa.2014.01.004; PMID: 24581932; PMCID: PMC7094469
Contact Info: van den Brand JMA; correspondence to T. Kuiken ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/24581932/
NHP Species: african green monkeys
Year Published: 2014
Study Type/Review:
NPRC/Institute: Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands
Keywords: SARS coronavirus, animal model, influenza, respiratory disease
Summary of Study: In this review, SARS-CoV infection is described in nonhuman primates (cynomolgus macaques and African green monkeys [AGMs]) and carnivores (ferrets and cats). This review focuses on the pathology and pathogenesis of SARS-CoV and influenza A virus infections, not only comparing the two viruses, but also comparing the pathology of these virus infections in experimental animals to that in man.
References: doi: 10.1016/j.jcpa.2014.01.004; PMID: 24581932; PMCID: PMC7094469
Contact Info: van den Brand JMA; correspondence to T. Kuiken ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/24581932/
Coronavirus Investigated: SARS-CoV
NHP Species: african green monkeys
Year Published: 2014
Study Type/Review:
NPRC/Institute: LRRI
Keywords: SARS-CoV, nonhuman primate, immune response
Summary of Study: Aged African green monkey SARS-CoV infection model to better understand age-related mechanisms of increased susceptibility to viral respiratory infections. Studies indicate that pulmonary immunity is intrinsically different in the aged as compared to the juvenile host.
References: doi: 10.1186/1742-4933-11-4; PMID: 24642138; PMCID: PMC3999990
Contact Info: Clay C, et al.; correspondence to Kevin S. Harrod ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/24642138/
NHP Species: african green monkeys
Year Published: 2014
Study Type/Review:
NPRC/Institute: LRRI
Keywords: SARS-CoV, nonhuman primate, immune response
Summary of Study: Aged African green monkey SARS-CoV infection model to better understand age-related mechanisms of increased susceptibility to viral respiratory infections. Studies indicate that pulmonary immunity is intrinsically different in the aged as compared to the juvenile host.
References: doi: 10.1186/1742-4933-11-4; PMID: 24642138; PMCID: PMC3999990
Contact Info: Clay C, et al.; correspondence to Kevin S. Harrod ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/24642138/
Coronavirus Investigated: MERS-CoV
NHP Species: marmosets
Year Published: 2014
Study Type/Review:
NPRC/Institute: NIAID
Keywords: MERS-CoV, DDP4, glycoprotein
Summary of Study: Infection with MERS-CoV causes lethal pneumonia in the common marmoset.
References: doi: 10.1371/journal.ppat.1004250; PMID: 25144235; PMCID: PMC4140844
Contact Info: Falzarano D, et al.; correspondence to Vincent Munster ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/25144235/
NHP Species: marmosets
Year Published: 2014
Study Type/Review:
NPRC/Institute: NIAID
Keywords: MERS-CoV, DDP4, glycoprotein
Summary of Study: Infection with MERS-CoV causes lethal pneumonia in the common marmoset.
References: doi: 10.1371/journal.ppat.1004250; PMID: 25144235; PMCID: PMC4140844
Contact Info: Falzarano D, et al.; correspondence to Vincent Munster ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/25144235/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2014
Study Type/Review:
NPRC/Institute: Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing
Keywords: MERS, animal model, coronavirus, pathology, rhesus monkey
Summary of Study: This study developed rhesus macaques as a model for MERS-CoV using intratracheal inoculation.
References: doi: 10.1093/infdis/jit590; PMID: 24218506; PMCID: PMC7107340
Contact Info: Yao Y, et al.; correspondence Chuan Qin ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/24218506/
NHP Species: rhesus macaques
Year Published: 2014
Study Type/Review:
NPRC/Institute: Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing
Keywords: MERS, animal model, coronavirus, pathology, rhesus monkey
Summary of Study: This study developed rhesus macaques as a model for MERS-CoV using intratracheal inoculation.
References: doi: 10.1093/infdis/jit590; PMID: 24218506; PMCID: PMC7107340
Contact Info: Yao Y, et al.; correspondence Chuan Qin ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/24218506/
Coronavirus Investigated: SARS-CoV
NHP Species: african green monkeys
Year Published: 2014
Study Type/Review:
NPRC/Institute: LRRI
Keywords: SARS-CoV, nonhuman primate, immune response
Summary of Study: Aged African green monkey SARS-CoV infection model to better understand age-related mechanisms of increased susceptibility to viral respiratory infections. Studies indicate that pulmonary immunity is intrinsically different in the aged as compared to the juvenile host.
References: doi: 10.1186/1742-4933-11-4; PMID: 24642138; PMCID: PMC3999990
Contact Info: Clay C, et al.; correspondence to Kevin S. Harrod ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/24642138/
NHP Species: african green monkeys
Year Published: 2014
Study Type/Review:
NPRC/Institute: LRRI
Keywords: SARS-CoV, nonhuman primate, immune response
Summary of Study: Aged African green monkey SARS-CoV infection model to better understand age-related mechanisms of increased susceptibility to viral respiratory infections. Studies indicate that pulmonary immunity is intrinsically different in the aged as compared to the juvenile host.
References: doi: 10.1186/1742-4933-11-4; PMID: 24642138; PMCID: PMC3999990
Contact Info: Clay C, et al.; correspondence to Kevin S. Harrod ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/24642138/
Coronavirus Investigated: SARS-CoV
NHP Species: african green monkeys
Year Published: 2014
Study Type/Review:
NPRC/Institute: Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands
Keywords: SARS coronavirus, animal model, influenza, respiratory disease
Summary of Study: In this review, SARS-CoV infection is described in nonhuman primates (cynomolgus macaques and African green monkeys [AGMs]) and carnivores (ferrets and cats). This review focuses on the pathology and pathogenesis of SARS-CoV and influenza A virus infections, not only comparing the two viruses, but also comparing the pathology of these virus infections in experimental animals to that in man.
References: doi: 10.1016/j.jcpa.2014.01.004; PMID: 24581932; PMCID: PMC7094469
Contact Info: van den Brand JMA; correspondence to T. Kuiken ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/24581932/
NHP Species: african green monkeys
Year Published: 2014
Study Type/Review:
NPRC/Institute: Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands
Keywords: SARS coronavirus, animal model, influenza, respiratory disease
Summary of Study: In this review, SARS-CoV infection is described in nonhuman primates (cynomolgus macaques and African green monkeys [AGMs]) and carnivores (ferrets and cats). This review focuses on the pathology and pathogenesis of SARS-CoV and influenza A virus infections, not only comparing the two viruses, but also comparing the pathology of these virus infections in experimental animals to that in man.
References: doi: 10.1016/j.jcpa.2014.01.004; PMID: 24581932; PMCID: PMC7094469
Contact Info: van den Brand JMA; correspondence to T. Kuiken ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/24581932/
Coronavirus Investigated: MERS-CoV
NHP Species: marmosets
Year Published: 2014
Study Type/Review:
NPRC/Institute: NIAID
Keywords: MERS-CoV, DDP4, glycoprotein
Summary of Study: Infection with MERS-CoV causes lethal pneumonia in the common marmoset.
References: doi: 10.1371/journal.ppat.1004250; PMID: 25144235; PMCID: PMC4140844
Contact Info: Falzarano D, et al.; correspondence to Vincent Munster ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/25144235/
NHP Species: marmosets
Year Published: 2014
Study Type/Review:
NPRC/Institute: NIAID
Keywords: MERS-CoV, DDP4, glycoprotein
Summary of Study: Infection with MERS-CoV causes lethal pneumonia in the common marmoset.
References: doi: 10.1371/journal.ppat.1004250; PMID: 25144235; PMCID: PMC4140844
Contact Info: Falzarano D, et al.; correspondence to Vincent Munster ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/25144235/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2013
Study Type/Review:
NPRC/Institute: Liver Disease Center for Military Staff, Beijing, China
Keywords: SARS, convalescent sera, safety
Summary of Study: This study assesses the safety of a serum obtained from a convalescent SARS patient. The study was conducted in rhesus macaques, a valuable model for the evaluation of candidate therapeutic agents for SARS infection.
References: doi: 10.3760/cma.j.issn.0366-6999.20130958; PMID: 24112184
Contact Info: He W, et al.; correspondence to Cheng Yun ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/24112184/
NHP Species: rhesus macaques
Year Published: 2013
Study Type/Review:
NPRC/Institute: Liver Disease Center for Military Staff, Beijing, China
Keywords: SARS, convalescent sera, safety
Summary of Study: This study assesses the safety of a serum obtained from a convalescent SARS patient. The study was conducted in rhesus macaques, a valuable model for the evaluation of candidate therapeutic agents for SARS infection.
References: doi: 10.3760/cma.j.issn.0366-6999.20130958; PMID: 24112184
Contact Info: He W, et al.; correspondence to Cheng Yun ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/24112184/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2013
Study Type/Review:
NPRC/Institute: NIAID, Wisconsin National Primate Research Center
Keywords: viral infection, drug therapy
Summary of Study: The combination of interferon-α2b and ribavirin was effective in reducing MERS-CoV replication in vitro.
References: doi: 10.1038/nm.3362; PMID: 24013700; PMCID: PMC4093902
Contact Info: Falzarano D, et al.; correspondence to Heinz Feldmann ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/24013700/
NHP Species: rhesus macaques
Year Published: 2013
Study Type/Review:
NPRC/Institute: NIAID, Wisconsin National Primate Research Center
Keywords: viral infection, drug therapy
Summary of Study: The combination of interferon-α2b and ribavirin was effective in reducing MERS-CoV replication in vitro.
References: doi: 10.1038/nm.3362; PMID: 24013700; PMCID: PMC4093902
Contact Info: Falzarano D, et al.; correspondence to Heinz Feldmann ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/24013700/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2013
Study Type/Review:
NPRC/Institute: NIAID
Keywords: DPP4, emerging infectious disease
Summary of Study: Upon a combination of intratracheal, ocular, oral, and intranasal inoculation with 7 × 106 50% tissue culture infectious dose of the MERS-CoV isolate HCoV-EMC/2012, rhesus macaques developed a transient lower respiratory tract infection.
References: doi: 10.1073/pnas.1310744110; PMID: 24062443; PMCID: PMC3799368
Contact Info: de Witt E, et al.; correspondence to Vincent Munster ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/24062443/
NHP Species: rhesus macaques
Year Published: 2013
Study Type/Review:
NPRC/Institute: NIAID
Keywords: DPP4, emerging infectious disease
Summary of Study: Upon a combination of intratracheal, ocular, oral, and intranasal inoculation with 7 × 106 50% tissue culture infectious dose of the MERS-CoV isolate HCoV-EMC/2012, rhesus macaques developed a transient lower respiratory tract infection.
References: doi: 10.1073/pnas.1310744110; PMID: 24062443; PMCID: PMC3799368
Contact Info: de Witt E, et al.; correspondence to Vincent Munster ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/24062443/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2013
Study Type/Review:
NPRC/Institute: NIAID, Wisconsin National Primate Research Center
Keywords: viral infection, drug therapy
Summary of Study: The combination of interferon-α2b and ribavirin was effective in reducing MERS-CoV replication in vitro.
References: doi: 10.1038/nm.3362; PMID: 24013700; PMCID: PMC4093902
Contact Info: Falzarano D, et al.; correspondence to Heinz Feldmann ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/24013700/
NHP Species: rhesus macaques
Year Published: 2013
Study Type/Review:
NPRC/Institute: NIAID, Wisconsin National Primate Research Center
Keywords: viral infection, drug therapy
Summary of Study: The combination of interferon-α2b and ribavirin was effective in reducing MERS-CoV replication in vitro.
References: doi: 10.1038/nm.3362; PMID: 24013700; PMCID: PMC4093902
Contact Info: Falzarano D, et al.; correspondence to Heinz Feldmann ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/24013700/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2013
Study Type/Review:
NPRC/Institute: Liver Disease Center for Military Staff, Beijing, China
Keywords: SARS, convalescent sera, safety
Summary of Study: This study assesses the safety of a serum obtained from a convalescent SARS patient. The study was conducted in rhesus macaques, a valuable model for the evaluation of candidate therapeutic agents for SARS infection.
References: doi: 10.3760/cma.j.issn.0366-6999.20130958; PMID: 24112184
Contact Info: He W, et al.; correspondence to Cheng Yun ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/24112184/
NHP Species: rhesus macaques
Year Published: 2013
Study Type/Review:
NPRC/Institute: Liver Disease Center for Military Staff, Beijing, China
Keywords: SARS, convalescent sera, safety
Summary of Study: This study assesses the safety of a serum obtained from a convalescent SARS patient. The study was conducted in rhesus macaques, a valuable model for the evaluation of candidate therapeutic agents for SARS infection.
References: doi: 10.3760/cma.j.issn.0366-6999.20130958; PMID: 24112184
Contact Info: He W, et al.; correspondence to Cheng Yun ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/24112184/
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2013
Study Type/Review:
NPRC/Institute: NIAID
Keywords: DPP4, emerging infectious disease
Summary of Study: Upon a combination of intratracheal, ocular, oral, and intranasal inoculation with 7 × 106 50% tissue culture infectious dose of the MERS-CoV isolate HCoV-EMC/2012, rhesus macaques developed a transient lower respiratory tract infection.
References: doi: 10.1073/pnas.1310744110; PMID: 24062443; PMCID: PMC3799368
Contact Info: de Witt E, et al.; correspondence to Vincent Munster ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/24062443/
NHP Species: rhesus macaques
Year Published: 2013
Study Type/Review:
NPRC/Institute: NIAID
Keywords: DPP4, emerging infectious disease
Summary of Study: Upon a combination of intratracheal, ocular, oral, and intranasal inoculation with 7 × 106 50% tissue culture infectious dose of the MERS-CoV isolate HCoV-EMC/2012, rhesus macaques developed a transient lower respiratory tract infection.
References: doi: 10.1073/pnas.1310744110; PMID: 24062443; PMCID: PMC3799368
Contact Info: de Witt E, et al.; correspondence to Vincent Munster ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/24062443/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2011
Study Type/Review:
NPRC/Institute: AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong/TNPRC base grant RR00164
Keywords: SARS-CoV, ACE2, nonhuman primate
Summary of Study: Here the distribution of ACE2+ cells in the respiratory tract of Chinese rhesus macaques, which mimics the human situation and extends those observations to more proximal tissues of the respiratory tract than have been examined in humans.
References: doi: 10.1128/JVI.02292-10
Contact Info: Liu L, et al.; correspondence to Chuan Qin ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/21289121/
NHP Species: rhesus macaques
Year Published: 2011
Study Type/Review:
NPRC/Institute: AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong/TNPRC base grant RR00164
Keywords: SARS-CoV, ACE2, nonhuman primate
Summary of Study: Here the distribution of ACE2+ cells in the respiratory tract of Chinese rhesus macaques, which mimics the human situation and extends those observations to more proximal tissues of the respiratory tract than have been examined in humans.
References: doi: 10.1128/JVI.02292-10
Contact Info: Liu L, et al.; correspondence to Chuan Qin ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/21289121/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2011
Study Type/Review:
NPRC/Institute: Department of Infectious Diseases, National Center for Global Health and Medicine
Keywords: SARS-CoV, coronavirus, nonhuman primate, 5H10
Summary of Study: Evaluate the efficacy of a fully human monoclonal antibody capable of neutralizing SARS-CoV in vitro in a rhesus macaque model of SARS.
References: doi: 10.1093/infdis/jir084; PMID: 21592986; PMCID: PMC7107252
Contact Info: Miyoshi-Akiyama T, et al.; correspondence to Tohru Miyoshi-Akiyama ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/21592986/
NHP Species: rhesus macaques
Year Published: 2011
Study Type/Review:
NPRC/Institute: Department of Infectious Diseases, National Center for Global Health and Medicine
Keywords: SARS-CoV, coronavirus, nonhuman primate, 5H10
Summary of Study: Evaluate the efficacy of a fully human monoclonal antibody capable of neutralizing SARS-CoV in vitro in a rhesus macaque model of SARS.
References: doi: 10.1093/infdis/jir084; PMID: 21592986; PMCID: PMC7107252
Contact Info: Miyoshi-Akiyama T, et al.; correspondence to Tohru Miyoshi-Akiyama ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/21592986/
Coronavirus Investigated: SARS-CoV
NHP Species: african green monkeys
Year Published: 2011
Study Type/Review:
NPRC/Institute: Department of Virology, Erasmus Medical Center, Rotterdam, Netherlands
Keywords: ARDS, SARS, interleukin, acute lung injury
Summary of Study: To obtain further insight into the pathogenesis of SARS-CoV-associated ALI, we compared SARS-CoV infections in two different nonhuman primate species, cynomolgus macaques and African green monkeys. Viral titers in the upper and lower respiratory tract were not significantly different in SARS-CoV-infected macaques and African green monkeys.
References: doi: 10.1128/JVI.02395-10
Contact Info: Smits SL, et al.; correspondence to Saskia L. Smits ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/21325418/
NHP Species: african green monkeys
Year Published: 2011
Study Type/Review:
NPRC/Institute: Department of Virology, Erasmus Medical Center, Rotterdam, Netherlands
Keywords: ARDS, SARS, interleukin, acute lung injury
Summary of Study: To obtain further insight into the pathogenesis of SARS-CoV-associated ALI, we compared SARS-CoV infections in two different nonhuman primate species, cynomolgus macaques and African green monkeys. Viral titers in the upper and lower respiratory tract were not significantly different in SARS-CoV-infected macaques and African green monkeys.
References: doi: 10.1128/JVI.02395-10
Contact Info: Smits SL, et al.; correspondence to Saskia L. Smits ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/21325418/
Coronavirus Investigated: SARS-CoV
NHP Species:
Year Published: 2011
Study Type/Review:
NPRC/Institute: NIAID
Keywords: SARS-CoV, coronavirus, nonhuman primate
Summary of Study: Cynomolgus macaques were challenged via intratracheal and intranasal routes with the recombinant Urbani, GZjO2 and HC/SZ/61/03 SARS-CoV strains. This study demonstrates that cynomolgus macaques can be infected with zoonotic and early human epidemic phase SARS-CoV strains.
References: doi: 10.1371/journal.pone.0018558; PMID: 21533129
Contact Info: Rockx B, et al.; correspondence to Barry Rockx ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/21533129/
NHP Species:
Year Published: 2011
Study Type/Review:
NPRC/Institute: NIAID
Keywords: SARS-CoV, coronavirus, nonhuman primate
Summary of Study: Cynomolgus macaques were challenged via intratracheal and intranasal routes with the recombinant Urbani, GZjO2 and HC/SZ/61/03 SARS-CoV strains. This study demonstrates that cynomolgus macaques can be infected with zoonotic and early human epidemic phase SARS-CoV strains.
References: doi: 10.1371/journal.pone.0018558; PMID: 21533129
Contact Info: Rockx B, et al.; correspondence to Barry Rockx ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/21533129/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2011
Study Type/Review:
NPRC/Institute: AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong/TNPRC base grant RR00164
Keywords: SARS-CoV, ACE2, nonhuman primate
Summary of Study: Here the distribution of ACE2+ cells in the respiratory tract of Chinese rhesus macaques, which mimics the human situation and extends those observations to more proximal tissues of the respiratory tract than have been examined in humans.
References: doi: 10.1128/JVI.02292-10
Contact Info: Liu L, et al.; correspondence to Chuan Qin ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/21289121/
NHP Species: rhesus macaques
Year Published: 2011
Study Type/Review:
NPRC/Institute: AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong/TNPRC base grant RR00164
Keywords: SARS-CoV, ACE2, nonhuman primate
Summary of Study: Here the distribution of ACE2+ cells in the respiratory tract of Chinese rhesus macaques, which mimics the human situation and extends those observations to more proximal tissues of the respiratory tract than have been examined in humans.
References: doi: 10.1128/JVI.02292-10
Contact Info: Liu L, et al.; correspondence to Chuan Qin ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/21289121/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2011
Study Type/Review:
NPRC/Institute: Department of Infectious Diseases, National Center for Global Health and Medicine
Keywords: SARS-CoV, coronavirus, nonhuman primate, 5H10
Summary of Study: Evaluate the efficacy of a fully human monoclonal antibody capable of neutralizing SARS-CoV in vitro in a rhesus macaque model of SARS.
References: doi: 10.1093/infdis/jir084; PMID: 21592986; PMCID: PMC7107252
Contact Info: Miyoshi-Akiyama T, et al.; correspondence to Tohru Miyoshi-Akiyama ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/21592986/
NHP Species: rhesus macaques
Year Published: 2011
Study Type/Review:
NPRC/Institute: Department of Infectious Diseases, National Center for Global Health and Medicine
Keywords: SARS-CoV, coronavirus, nonhuman primate, 5H10
Summary of Study: Evaluate the efficacy of a fully human monoclonal antibody capable of neutralizing SARS-CoV in vitro in a rhesus macaque model of SARS.
References: doi: 10.1093/infdis/jir084; PMID: 21592986; PMCID: PMC7107252
Contact Info: Miyoshi-Akiyama T, et al.; correspondence to Tohru Miyoshi-Akiyama ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/21592986/
Coronavirus Investigated: SARS-CoV
NHP Species: african green monkeys
Year Published: 2011
Study Type/Review:
NPRC/Institute: Department of Virology, Erasmus Medical Center, Rotterdam, Netherlands
Keywords: ARDS, SARS, interleukin, acute lung injury
Summary of Study: To obtain further insight into the pathogenesis of SARS-CoV-associated ALI, we compared SARS-CoV infections in two different nonhuman primate species, cynomolgus macaques and African green monkeys. Viral titers in the upper and lower respiratory tract were not significantly different in SARS-CoV-infected macaques and African green monkeys.
References: doi: 10.1128/JVI.02395-10
Contact Info: Smits SL, et al.; correspondence to Saskia L. Smits ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/21325418/
NHP Species: african green monkeys
Year Published: 2011
Study Type/Review:
NPRC/Institute: Department of Virology, Erasmus Medical Center, Rotterdam, Netherlands
Keywords: ARDS, SARS, interleukin, acute lung injury
Summary of Study: To obtain further insight into the pathogenesis of SARS-CoV-associated ALI, we compared SARS-CoV infections in two different nonhuman primate species, cynomolgus macaques and African green monkeys. Viral titers in the upper and lower respiratory tract were not significantly different in SARS-CoV-infected macaques and African green monkeys.
References: doi: 10.1128/JVI.02395-10
Contact Info: Smits SL, et al.; correspondence to Saskia L. Smits ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/21325418/
Coronavirus Investigated: SARS-CoV
NHP Species:
Year Published: 2011
Study Type/Review:
NPRC/Institute: NIAID
Keywords: SARS-CoV, coronavirus, nonhuman primate
Summary of Study: Cynomolgus macaques were challenged via intratracheal and intranasal routes with the recombinant Urbani, GZjO2 and HC/SZ/61/03 SARS-CoV strains. This study demonstrates that cynomolgus macaques can be infected with zoonotic and early human epidemic phase SARS-CoV strains.
References: doi: 10.1371/journal.pone.0018558; PMID: 21533129
Contact Info: Rockx B, et al.; correspondence to Barry Rockx ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/21533129/
NHP Species:
Year Published: 2011
Study Type/Review:
NPRC/Institute: NIAID
Keywords: SARS-CoV, coronavirus, nonhuman primate
Summary of Study: Cynomolgus macaques were challenged via intratracheal and intranasal routes with the recombinant Urbani, GZjO2 and HC/SZ/61/03 SARS-CoV strains. This study demonstrates that cynomolgus macaques can be infected with zoonotic and early human epidemic phase SARS-CoV strains.
References: doi: 10.1371/journal.pone.0018558; PMID: 21533129
Contact Info: Rockx B, et al.; correspondence to Barry Rockx ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/21533129/
Coronavirus Investigated: SARS-CoV
NHP Species:
Year Published: 2010
Study Type/Review:
NPRC/Institute: Department of Virology III, National Institute of Infectious Diseases, Japan
Keywords: SARS-CoV, ACE2, TMPRSS2, S protein
Summary of Study: Identified transmembrane protease serine 2 (TMPRSS2), whose expression does correlate with SARS-CoV infection in the upper lobe of the lung in cynomolgus monkeys.
References: doi: 10.1128/JVI.01542-10; PMID: 20926566
Contact Info: Matsuyama S, et al.; correspondence to Shutoku Matsuyama ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/20926566/
NHP Species:
Year Published: 2010
Study Type/Review:
NPRC/Institute: Department of Virology III, National Institute of Infectious Diseases, Japan
Keywords: SARS-CoV, ACE2, TMPRSS2, S protein
Summary of Study: Identified transmembrane protease serine 2 (TMPRSS2), whose expression does correlate with SARS-CoV infection in the upper lobe of the lung in cynomolgus monkeys.
References: doi: 10.1128/JVI.01542-10; PMID: 20926566
Contact Info: Matsuyama S, et al.; correspondence to Shutoku Matsuyama ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/20926566/
Coronavirus Investigated: SARS-CoV
NHP Species:
Year Published: 2010
Study Type/Review:
NPRC/Institute: Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands, NIH grant HL080621-01A1 and the Virgo consortium
Keywords: SARS-CoV, ARDS, acute lung injury, NF-kappaB, interferon
Summary of Study: SARS-CoV-infected aged macaques develop more severe pathology than young adult animals, even though viral replication levels are similar.
References: doi: 10.1371/journal.ppat.1000756; PMID: 20140198; PMCID: PMC2816697
Contact Info: Smits SL, et al.; correspondence to Saskia L. Smits ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/20140198/
NHP Species:
Year Published: 2010
Study Type/Review:
NPRC/Institute: Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands, NIH grant HL080621-01A1 and the Virgo consortium
Keywords: SARS-CoV, ARDS, acute lung injury, NF-kappaB, interferon
Summary of Study: SARS-CoV-infected aged macaques develop more severe pathology than young adult animals, even though viral replication levels are similar.
References: doi: 10.1371/journal.ppat.1000756; PMID: 20140198; PMCID: PMC2816697
Contact Info: Smits SL, et al.; correspondence to Saskia L. Smits ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/20140198/
Coronavirus Investigated: SARS-CoV
NHP Species:
Year Published: 2010
Study Type/Review:
NPRC/Institute: Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands, NIH grant HL080621-01A1 and the Virgo consortium
Keywords: SARS-CoV, ARDS, acute lung injury, NF-kappaB, interferon
Summary of Study: SARS-CoV-infected aged macaques develop more severe pathology than young adult animals, even though viral replication levels are similar.
References: doi: 10.1371/journal.ppat.1000756; PMID: 20140198; PMCID: PMC2816697
Contact Info: Smits SL, et al.; correspondence to Saskia L. Smits ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/20140198/
NHP Species:
Year Published: 2010
Study Type/Review:
NPRC/Institute: Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands, NIH grant HL080621-01A1 and the Virgo consortium
Keywords: SARS-CoV, ARDS, acute lung injury, NF-kappaB, interferon
Summary of Study: SARS-CoV-infected aged macaques develop more severe pathology than young adult animals, even though viral replication levels are similar.
References: doi: 10.1371/journal.ppat.1000756; PMID: 20140198; PMCID: PMC2816697
Contact Info: Smits SL, et al.; correspondence to Saskia L. Smits ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/20140198/
Coronavirus Investigated: SARS-CoV
NHP Species:
Year Published: 2010
Study Type/Review:
NPRC/Institute: Department of Virology III, National Institute of Infectious Diseases, Japan
Keywords: SARS-CoV, ACE2, TMPRSS2, S protein
Summary of Study: Identified transmembrane protease serine 2 (TMPRSS2), whose expression does correlate with SARS-CoV infection in the upper lobe of the lung in cynomolgus monkeys.
References: doi: 10.1128/JVI.01542-10; PMID: 20926566
Contact Info: Matsuyama S, et al.; correspondence to Shutoku Matsuyama ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/20926566/
NHP Species:
Year Published: 2010
Study Type/Review:
NPRC/Institute: Department of Virology III, National Institute of Infectious Diseases, Japan
Keywords: SARS-CoV, ACE2, TMPRSS2, S protein
Summary of Study: Identified transmembrane protease serine 2 (TMPRSS2), whose expression does correlate with SARS-CoV infection in the upper lobe of the lung in cynomolgus monkeys.
References: doi: 10.1128/JVI.01542-10; PMID: 20926566
Contact Info: Matsuyama S, et al.; correspondence to Shutoku Matsuyama ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/20926566/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2009
Study Type/Review:
NPRC/Institute: Sino-German collaborative grant GZ230 (202/3)
Keywords: A549 cell, SARS, yeast strain AH109, SARS-CoV
Summary of Study: Ddx5 is a multifunctional protein important for studying virus–host cell interactions in SARS-CoV infections in rhesus macaques.
References: doi: 10.1007/s00705-009-0323-y; PMID: 19224332; PMCID: PMC7087151
Contact Info: Chang JY, et al.; correspondence to Yu-Mei Wen ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/19224332/
NHP Species: rhesus macaques
Year Published: 2009
Study Type/Review:
NPRC/Institute: Sino-German collaborative grant GZ230 (202/3)
Keywords: A549 cell, SARS, yeast strain AH109, SARS-CoV
Summary of Study: Ddx5 is a multifunctional protein important for studying virus–host cell interactions in SARS-CoV infections in rhesus macaques.
References: doi: 10.1007/s00705-009-0323-y; PMID: 19224332; PMCID: PMC7087151
Contact Info: Chang JY, et al.; correspondence to Yu-Mei Wen ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/19224332/
Coronavirus Investigated: SARS-CoV
NHP Species:
Year Published: 2009
Study Type/Review:
NPRC/Institute: NIH grant HL080621-01A1 and the Virgo consortium, an Innovative Cluster approved by the Netherlands Genomics Initiative
Keywords: innate immunity, interferon, plasmacytoid dendritic cell, SARS-CoV
Summary of Study: Interferon production plays a role during SARS-CoV infection in vitro and in cynomolgus macaque studies.
References: doi: 10.2217/17460794.4.1.71; PMID: 19885368; PMCID: PMC2680287; NIHMSID: NIHMS88172
Contact Info: de Lang A, et al.; correspondence to Bart Haagmans ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/19885368/
NHP Species:
Year Published: 2009
Study Type/Review:
NPRC/Institute: NIH grant HL080621-01A1 and the Virgo consortium, an Innovative Cluster approved by the Netherlands Genomics Initiative
Keywords: innate immunity, interferon, plasmacytoid dendritic cell, SARS-CoV
Summary of Study: Interferon production plays a role during SARS-CoV infection in vitro and in cynomolgus macaque studies.
References: doi: 10.2217/17460794.4.1.71; PMID: 19885368; PMCID: PMC2680287; NIHMSID: NIHMS88172
Contact Info: de Lang A, et al.; correspondence to Bart Haagmans ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/19885368/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2009
Study Type/Review:
NPRC/Institute: Sino-German collaborative grant GZ230 (202/3)
Keywords: A549 cell, SARS, yeast strain AH109, SARS-CoV
Summary of Study: Ddx5 is a multifunctional protein important for studying virus–host cell interactions in SARS-CoV infections in rhesus macaques.
References: doi: 10.1007/s00705-009-0323-y; PMID: 19224332; PMCID: PMC7087151
Contact Info: Chang JY, et al.; correspondence to Yu-Mei Wen ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/19224332/
NHP Species: rhesus macaques
Year Published: 2009
Study Type/Review:
NPRC/Institute: Sino-German collaborative grant GZ230 (202/3)
Keywords: A549 cell, SARS, yeast strain AH109, SARS-CoV
Summary of Study: Ddx5 is a multifunctional protein important for studying virus–host cell interactions in SARS-CoV infections in rhesus macaques.
References: doi: 10.1007/s00705-009-0323-y; PMID: 19224332; PMCID: PMC7087151
Contact Info: Chang JY, et al.; correspondence to Yu-Mei Wen ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/19224332/
Coronavirus Investigated: SARS-CoV
NHP Species:
Year Published: 2009
Study Type/Review:
NPRC/Institute: NIH grant HL080621-01A1 and the Virgo consortium, an Innovative Cluster approved by the Netherlands Genomics Initiative
Keywords: innate immunity, interferon, plasmacytoid dendritic cell, SARS-CoV
Summary of Study: Interferon production plays a role during SARS-CoV infection in vitro and in cynomolgus macaque studies.
References: doi: 10.2217/17460794.4.1.71; PMID: 19885368; PMCID: PMC2680287; NIHMSID: NIHMS88172
Contact Info: de Lang A, et al.; correspondence to Bart Haagmans ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/19885368/
NHP Species:
Year Published: 2009
Study Type/Review:
NPRC/Institute: NIH grant HL080621-01A1 and the Virgo consortium, an Innovative Cluster approved by the Netherlands Genomics Initiative
Keywords: innate immunity, interferon, plasmacytoid dendritic cell, SARS-CoV
Summary of Study: Interferon production plays a role during SARS-CoV infection in vitro and in cynomolgus macaque studies.
References: doi: 10.2217/17460794.4.1.71; PMID: 19885368; PMCID: PMC2680287; NIHMSID: NIHMS88172
Contact Info: de Lang A, et al.; correspondence to Bart Haagmans ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/19885368/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2008
Study Type/Review:
NPRC/Institute: Science and Technology Commission, Guangdong Provincial Government, Guangzhou Science and Technology Bureau, Guangzhou Economic & Technological Development District, etc.
Keywords: RNAi, siRNA, SARS, SARS-CoV, diffuse alveoli damage, proinflammatory cytokines
Summary of Study: Results in rhesus macaques support clinical investigation of siRNA to treat SARS.
References: doi: 10.1007/978-1-59745-191-8_11; PMID: 18369784; PMCID: PMC7121115
Contact Info: Tang Q, et al.
URL: https://pubmed.ncbi.nlm.nih.gov/18369784/
NHP Species: rhesus macaques
Year Published: 2008
Study Type/Review:
NPRC/Institute: Science and Technology Commission, Guangdong Provincial Government, Guangzhou Science and Technology Bureau, Guangzhou Economic & Technological Development District, etc.
Keywords: RNAi, siRNA, SARS, SARS-CoV, diffuse alveoli damage, proinflammatory cytokines
Summary of Study: Results in rhesus macaques support clinical investigation of siRNA to treat SARS.
References: doi: 10.1007/978-1-59745-191-8_11; PMID: 18369784; PMCID: PMC7121115
Contact Info: Tang Q, et al.
URL: https://pubmed.ncbi.nlm.nih.gov/18369784/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2008
Study Type/Review:
NPRC/Institute: NIH 1R01 HL080211-01, NIH 1R01 HL080211-01, Development Fund of the University of Hong Kong (UDF)
Keywords: SARS, SARS-CoV, ACE2, Chinese rhesus monkey, lung pathogenesis
Summary of Study: Y217N mutation plays a role in modulating SARS-CoV infection in rhesus macaques.
References: doi: 10.1016/j.virol.2008.08.016; PMID: 18801550; PMCID: PMC7103406
Contact Info: Chen Y, et al.; correspondence to Zhiwei Chen ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/18801550/
NHP Species: rhesus macaques
Year Published: 2008
Study Type/Review:
NPRC/Institute: NIH 1R01 HL080211-01, NIH 1R01 HL080211-01, Development Fund of the University of Hong Kong (UDF)
Keywords: SARS, SARS-CoV, ACE2, Chinese rhesus monkey, lung pathogenesis
Summary of Study: Y217N mutation plays a role in modulating SARS-CoV infection in rhesus macaques.
References: doi: 10.1016/j.virol.2008.08.016; PMID: 18801550; PMCID: PMC7103406
Contact Info: Chen Y, et al.; correspondence to Zhiwei Chen ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/18801550/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2008
Study Type/Review:
NPRC/Institute: NIH 1R01 HL080211-01, NIH 1R01 HL080211-01, Development Fund of the University of Hong Kong (UDF)
Keywords: SARS, SARS-CoV, ACE2, Chinese rhesus monkey, lung pathogenesis
Summary of Study: Y217N mutation plays a role in modulating SARS-CoV infection in rhesus macaques.
References: doi: 10.1016/j.virol.2008.08.016; PMID: 18801550; PMCID: PMC7103406
Contact Info: Chen Y, et al.; correspondence to Zhiwei Chen ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/18801550/
NHP Species: rhesus macaques
Year Published: 2008
Study Type/Review:
NPRC/Institute: NIH 1R01 HL080211-01, NIH 1R01 HL080211-01, Development Fund of the University of Hong Kong (UDF)
Keywords: SARS, SARS-CoV, ACE2, Chinese rhesus monkey, lung pathogenesis
Summary of Study: Y217N mutation plays a role in modulating SARS-CoV infection in rhesus macaques.
References: doi: 10.1016/j.virol.2008.08.016; PMID: 18801550; PMCID: PMC7103406
Contact Info: Chen Y, et al.; correspondence to Zhiwei Chen ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/18801550/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2008
Study Type/Review:
NPRC/Institute: Science and Technology Commission, Guangdong Provincial Government, Guangzhou Science and Technology Bureau, Guangzhou Economic & Technological Development District, etc.
Keywords: RNAi, siRNA, SARS, SARS-CoV, diffuse alveoli damage, proinflammatory cytokines
Summary of Study: Results in rhesus macaques support clinical investigation of siRNA to treat SARS.
References: doi: 10.1007/978-1-59745-191-8_11; PMID: 18369784; PMCID: PMC7121115
Contact Info: Tang Q, et al.
URL: https://pubmed.ncbi.nlm.nih.gov/18369784/
NHP Species: rhesus macaques
Year Published: 2008
Study Type/Review:
NPRC/Institute: Science and Technology Commission, Guangdong Provincial Government, Guangzhou Science and Technology Bureau, Guangzhou Economic & Technological Development District, etc.
Keywords: RNAi, siRNA, SARS, SARS-CoV, diffuse alveoli damage, proinflammatory cytokines
Summary of Study: Results in rhesus macaques support clinical investigation of siRNA to treat SARS.
References: doi: 10.1007/978-1-59745-191-8_11; PMID: 18369784; PMCID: PMC7121115
Contact Info: Tang Q, et al.
URL: https://pubmed.ncbi.nlm.nih.gov/18369784/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2007
Study Type/Review:
NPRC/Institute: National Key Basic Research Program of China (“973†Projects): Fund for the Basic Research of SARS Prevention (2003CB514108), Key Research Project of Natural Science Foundation of China (No.30490240), etc.
Keywords: SARS-CoV-2, equine, pharmacology, immunogenicity
Summary of Study: Equine anti-SARS–CoV F(ab′)2 is safe in macaques and can be used in prevention of SARS-CoV.
References: doi: 10.1016/j.intimp.2007.09.011; PMID: 17996696; PMCID: PMC7106090
Contact Info: Xu Y, et al.; correspondence to Yuzhang Wu ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/17996696/
NHP Species: rhesus macaques
Year Published: 2007
Study Type/Review:
NPRC/Institute: National Key Basic Research Program of China (“973†Projects): Fund for the Basic Research of SARS Prevention (2003CB514108), Key Research Project of Natural Science Foundation of China (No.30490240), etc.
Keywords: SARS-CoV-2, equine, pharmacology, immunogenicity
Summary of Study: Equine anti-SARS–CoV F(ab′)2 is safe in macaques and can be used in prevention of SARS-CoV.
References: doi: 10.1016/j.intimp.2007.09.011; PMID: 17996696; PMCID: PMC7106090
Contact Info: Xu Y, et al.; correspondence to Yuzhang Wu ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/17996696/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2007
Study Type/Review: vaccine
NPRC/Institute: GlaxoSmithKline Pharmaceuticals
Keywords: SARS, adenovirus, vaccine
Summary of Study: Adenovirus-based vaccine stimulates robust immune responses to SARS-CoV in rhesus macaques.
References: doi: 10.1016/j.vaccine.2007.04.065; PMID: 17559989; PMCID: PMC7115643
Contact Info: Kobinger GP, et al.; correspondence to James Wilson ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/17559989/
NHP Species: rhesus macaques
Year Published: 2007
Study Type/Review: vaccine
NPRC/Institute: GlaxoSmithKline Pharmaceuticals
Keywords: SARS, adenovirus, vaccine
Summary of Study: Adenovirus-based vaccine stimulates robust immune responses to SARS-CoV in rhesus macaques.
References: doi: 10.1016/j.vaccine.2007.04.065; PMID: 17559989; PMCID: PMC7115643
Contact Info: Kobinger GP, et al.; correspondence to James Wilson ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/17559989/
Coronavirus Investigated: SARS-CoV
NHP Species:
Year Published: 2007
Study Type/Review:
NPRC/Institute: NIH R01 grant HL080621-01A1, European Union grant SP-22-CT-2004–511060
Keywords: SARS-CoV, SARS, interleukin, interferon
Summary of Study: The induction of early IFN signaling may be critical to confer protection against SARS-CoV infection in cynomolgus macaques.
References: doi: 10.1371/journal.ppat.0030112; PMID: 17696609; PMCID: PMC1941749
Contact Info: de Lang A, et al.; correspondence to Bart Haagmans ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/17696609/
NHP Species:
Year Published: 2007
Study Type/Review:
NPRC/Institute: NIH R01 grant HL080621-01A1, European Union grant SP-22-CT-2004–511060
Keywords: SARS-CoV, SARS, interleukin, interferon
Summary of Study: The induction of early IFN signaling may be critical to confer protection against SARS-CoV infection in cynomolgus macaques.
References: doi: 10.1371/journal.ppat.0030112; PMID: 17696609; PMCID: PMC1941749
Contact Info: de Lang A, et al.; correspondence to Bart Haagmans ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/17696609/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2007
Study Type/Review:
NPRC/Institute: CIHR, CCFF and FFBC to Jim Hu, NSFC (30530420) and 973 projects (2001CB510006, 2002CB513007) to Zhijie Chang, etc.
Keywords: SARS, oseltamivir, rhesus macaque, airway epithelial cell, leader sequence
Summary of Study: siRNAs were effective in inhibiting SARS-CoV in rhesus macaques both prophylactically and therapeutically with no adverse effects in the animals.
References: doi: 10.2165/00063030-200721010-00002; PMID: 17263585; PMCID: PMC7099728
Contact Info: Chang Z, et al.; correspondence to Jim Hu ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/17263585/
NHP Species: rhesus macaques
Year Published: 2007
Study Type/Review:
NPRC/Institute: CIHR, CCFF and FFBC to Jim Hu, NSFC (30530420) and 973 projects (2001CB510006, 2002CB513007) to Zhijie Chang, etc.
Keywords: SARS, oseltamivir, rhesus macaque, airway epithelial cell, leader sequence
Summary of Study: siRNAs were effective in inhibiting SARS-CoV in rhesus macaques both prophylactically and therapeutically with no adverse effects in the animals.
References: doi: 10.2165/00063030-200721010-00002; PMID: 17263585; PMCID: PMC7099728
Contact Info: Chang Z, et al.; correspondence to Jim Hu ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/17263585/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2007
Study Type/Review:
NPRC/Institute: Medicine Foundation of China
Keywords: SARS-CoV, animal model, macaca rhesus
Summary of Study: Rhesus macaques infected with SARS-CoV developed the typical SARS according to clinical, virological, and pathological findings.
References: PMID: 18076307
Contact Info: Luo F, et al.; correspondence to David Hou ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/18076307/
NHP Species: rhesus macaques
Year Published: 2007
Study Type/Review:
NPRC/Institute: Medicine Foundation of China
Keywords: SARS-CoV, animal model, macaca rhesus
Summary of Study: Rhesus macaques infected with SARS-CoV developed the typical SARS according to clinical, virological, and pathological findings.
References: PMID: 18076307
Contact Info: Luo F, et al.; correspondence to David Hou ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/18076307/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2007
Study Type/Review: vaccine
NPRC/Institute: GlaxoSmithKline Pharmaceuticals
Keywords: SARS, adenovirus, vaccine
Summary of Study: Adenovirus-based vaccine stimulates robust immune responses to SARS-CoV in rhesus macaques.
References: doi: 10.1016/j.vaccine.2007.04.065; PMID: 17559989; PMCID: PMC7115643
Contact Info: Kobinger GP, et al.; correspondence to James Wilson ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/17559989/
NHP Species: rhesus macaques
Year Published: 2007
Study Type/Review: vaccine
NPRC/Institute: GlaxoSmithKline Pharmaceuticals
Keywords: SARS, adenovirus, vaccine
Summary of Study: Adenovirus-based vaccine stimulates robust immune responses to SARS-CoV in rhesus macaques.
References: doi: 10.1016/j.vaccine.2007.04.065; PMID: 17559989; PMCID: PMC7115643
Contact Info: Kobinger GP, et al.; correspondence to James Wilson ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/17559989/
Coronavirus Investigated: SARS-CoV
NHP Species:
Year Published: 2007
Study Type/Review:
NPRC/Institute: Research on Emerging and Re-emerging Infectious Diseases from the Ministry of Health, Labour and Welfare, Japan
Keywords: animal model, coronavirus, cynomolgus monkey, pathogenesis, SARS-CoV
Summary of Study: SARS-CoV appears to spread into and perhaps via the intestinal and lymphatic systems of cynomolgus macaques.
References: doi: 10.1111/j.1365-2613.2007.00567.x; PMID: 18039277; PMCID: PMC2517337
Contact Info: Nagata N, et al.; correspondence to Noriyo Nagata ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/18039277/
NHP Species:
Year Published: 2007
Study Type/Review:
NPRC/Institute: Research on Emerging and Re-emerging Infectious Diseases from the Ministry of Health, Labour and Welfare, Japan
Keywords: animal model, coronavirus, cynomolgus monkey, pathogenesis, SARS-CoV
Summary of Study: SARS-CoV appears to spread into and perhaps via the intestinal and lymphatic systems of cynomolgus macaques.
References: doi: 10.1111/j.1365-2613.2007.00567.x; PMID: 18039277; PMCID: PMC2517337
Contact Info: Nagata N, et al.; correspondence to Noriyo Nagata ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/18039277/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2007
Study Type/Review:
NPRC/Institute: National Key Basic Research Program of China (“973†Projects): Fund for the Basic Research of SARS Prevention (2003CB514108), Key Research Project of Natural Science Foundation of China (No.30490240), etc.
Keywords: SARS-CoV-2, equine, pharmacology, immunogenicity
Summary of Study: Equine anti-SARS–CoV F(ab′)2 is safe in macaques and can be used in prevention of SARS-CoV.
References: doi: 10.1016/j.intimp.2007.09.011; PMID: 17996696; PMCID: PMC7106090
Contact Info: Xu Y, et al.; correspondence to Yuzhang Wu ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/17996696/
NHP Species: rhesus macaques
Year Published: 2007
Study Type/Review:
NPRC/Institute: National Key Basic Research Program of China (“973†Projects): Fund for the Basic Research of SARS Prevention (2003CB514108), Key Research Project of Natural Science Foundation of China (No.30490240), etc.
Keywords: SARS-CoV-2, equine, pharmacology, immunogenicity
Summary of Study: Equine anti-SARS–CoV F(ab′)2 is safe in macaques and can be used in prevention of SARS-CoV.
References: doi: 10.1016/j.intimp.2007.09.011; PMID: 17996696; PMCID: PMC7106090
Contact Info: Xu Y, et al.; correspondence to Yuzhang Wu ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/17996696/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2007
Study Type/Review:
NPRC/Institute: CIHR, CCFF and FFBC to Jim Hu, NSFC (30530420) and 973 projects (2001CB510006, 2002CB513007) to Zhijie Chang, etc.
Keywords: SARS, oseltamivir, rhesus macaque, airway epithelial cell, leader sequence
Summary of Study: siRNAs were effective in inhibiting SARS-CoV in rhesus macaques both prophylactically and therapeutically with no adverse effects in the animals.
References: doi: 10.2165/00063030-200721010-00002; PMID: 17263585; PMCID: PMC7099728
Contact Info: Chang Z, et al.; correspondence to Jim Hu ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/17263585/
NHP Species: rhesus macaques
Year Published: 2007
Study Type/Review:
NPRC/Institute: CIHR, CCFF and FFBC to Jim Hu, NSFC (30530420) and 973 projects (2001CB510006, 2002CB513007) to Zhijie Chang, etc.
Keywords: SARS, oseltamivir, rhesus macaque, airway epithelial cell, leader sequence
Summary of Study: siRNAs were effective in inhibiting SARS-CoV in rhesus macaques both prophylactically and therapeutically with no adverse effects in the animals.
References: doi: 10.2165/00063030-200721010-00002; PMID: 17263585; PMCID: PMC7099728
Contact Info: Chang Z, et al.; correspondence to Jim Hu ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/17263585/