ORIP Strategic Plan 2021–2025 Archive

 

 


Progress on Theme 1: Animal Models to Advance the Study of Human Disease

Programs and Activities Highlights

  • ORIP Encourages the Development of Resources and Technologies for Enhancing Rigor, Reproducibility, and Translatability of Animal Models in Biomedical Research
    ORIP has issued a Notice of Special Interest (NOT-OD-22-039) for 2-year projects to support exploratory/developmental and highly innovative projects aimed at developing broadly applicable technologies, tools, and resources for validating animal models and enhancing the rigor, reproducibility, and translatability of animal research.

ORIP-Supported Research Highlights

  • Precise Visuomotor Transformations Underlying Collective Behavior in Larval Zebrafish
    Brain mechanisms involved in collective social behavior are mostly unknown. Investigators found how zebrafish transform visual cues into fast and accurate movement decisions when swimming in schools. For example, a fish might use the height of the fish surrounding it to estimate the distance to its neighbors.
  • Multiview Confocal Super-Resolution Microscopy
    Researchers, including NIH scientists, report major improvements in confocal microscopy, a “workhorse” biomedical imaging technology. By harnessing new multiview light sensing optical methods in combination with deep-learning image reconstruction, researchers have improved the spatial and temporal resolutions, speed, and depth penetration of confocal microscopy and were able to acquire high-resolution images with less light. Researchers demonstrated their improved capabilities on fixed and live samples of single cells, fly wings, and mouse heart and brain tissue.
  • AAV Capsid Variants with Brain-Wide Transgene Expression and Decreased Liver Targeting After Intravenous Delivery in Mouse and Marmoset
    Gene therapy using the shell (capsid) of adeno-associated viruses (AAVs) is increasingly being explored as a therapeutic option for debilitating disorders of the central nervous system. Investigators achieved organ-specific targeting of adeno-associated virus capsids after intravenous delivery in mice and marmosets. These results constitute an important step forward toward achieving the goal of engineered adeno-associated viruses that can be used to broadly deliver gene therapies to the central nervous system in humans.
  • BNT162b Vaccines Protect Rhesus Macaques from SARS-CoV-2.
    The preclinical development of two BNT162b vaccine candidates against SARS-CoV-2 was performed in rhesus macaques at the Southwest National Primate Research Center.
  • In Vitro and In Vivo Functions of SARS-CoV-2 Infection-Enhancing and Neutralizing Antibodies.
    Researchers isolated neutralizing antibodies against the receptor-binding domain (RBD) or N-terminal domain (NTD) of SARS-CoV-2 spike from COVID-19 patients. RBD and NTD antibodies mediated both neutralization and infection enhancement in vitro. RBD-neutralizing antibodies having cross-reactivity against coronaviruses protected against SARS-CoV-2 in vivo.
  • A Novel Tau-Based Rhesus Monkey Model of Alzheimer’s Pathogenesis.
    Researchers developed a new rhesus monkey model of Alzheimer’s disease by targeting the entorhinal cortex with an adeno-associated virus expressing a double tau mutation.
  • Cryopreservation Method for Drosophila melanogaster Embryos.
    Researchers reported a robust and efficient method for cryopreservation of Drosophila melanogaster embryos. The optimized method resulted in >10% of embryos developing into fertile adults after cryopreservation for 25 distinct strains from different sources.

Progress on Theme 2: Innovative Instruments and Equipment to Accelerate Research Discoveries

Programs and Activities Highlights

  • Virtual Construction and Renovation Site Visits for Awarded C06/G20 projects
    ORIP performed more than 70 final site visits virtually in 2021 covering more than 90 construction/renovation projects that are near the end of 10- or 20-year federal oversight periods. Information on overall impact, usage, and maintenance of grant-supported spaces is being reviewed. Most of these grant-supported spaces continue to be used for the biomedical research proposed in their original applications.

Research Highlights from Investigators Utilizing ORIP-Supported Instrumentation


Progress on Theme 3: Specialized Research Training in Animal Models and Related Resources

Programs and Activities Highlights

None at this time.

ORIP-Supported Research Highlights

None at this time.


Progress on Theme 4: Awareness of ORIP Resources and Programs

Programs and Activities Highlights

  • ORIP Webinar: “What Do Veterinarians (Who Are Also Scientists) Bring to Biomedical Research?”
    ORIP's Division of Comparative Medicine supports up to two webinars per year on topics of interest to K01 and F30 awardees. At the fall 2021 meeting, two veterinary scientists discussed their experiences as veterinarians working in biomedical research, as well as the knowledge, skills, and abilities that veterinary scientists bring to the biomedical research enterprise.
  • 2021 National Small Busines Innovation Research (SBIR) Week—Virtual Event
    ORIP participated in this national conference by meeting one-on-one with members of the small business community to provide feedback on project concepts, describe the interest areas of ORIP's Small Business Program, and respond to questions about the SBIR/Small Business Technology Transfer (STTR) application process.

Collaborations with Other NIH Institutes/Centers/Offices

None at this time.

 

Last updated: 06-09-2022