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BioGRID: Biological General Repository for Interaction Datasets

Grant Number: R01OD010929

BioGRID LogoResearch Emphasis/Objectives

The Biological General Repository for Interaction Datasets (BioGRID) is an open-access public database that uses structured curation to capture protein, genetic, and chemical interaction data from model organisms and humans. BioGRID currently holds over 2,600,000 interactions curated from both high-throughput datasets and individual focused studies. Complete coverage of the primary literature is maintained for budding yeast (S. cerevisiae), fission yeast (S. pombe), and thale cress (A. thaliana), as well as partial coverage for other model species. Curation of interactions in human cells is focused on aspects of biology that are particularly relevant to human health, including disease-themed projects such as for COVID-19. Comprehensive curation of published genome-wide CRISPR screens systematically captures gene–phenotype relationships.

Services Provided

The BioGRID 4.4 web interface contains new search and display features that enable rapid user queries across multiple data types and sources. BioGRID provides interaction data to the main model organism databases within the Alliance of Genome Resources, including SGD, PomBase, TAIR, Wormbase and FlyBase, as well as to meta-databases such as NCBI, UniProt, and PubChem. The entire BioGRID 4.4 data collection may be downloaded without restriction in multiple file formats, including IMEx-compatible PSI MI XML. For developers, BioGRID interactions are also available via a REST-based Web Service and Cytoscape plugin. All BioGRID documentation is available online in the BioGRID Wiki.



Contact Information

Mike Tyers
Senior Scientist
Peter Gilgan Centre for Research and Learning
The Hospital for Sick Children
686 Bay Street
ON M5G 0A4