Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Federal Medical-Biological Agency of Russia, Moscow, Russia; Saint Petersburg Scientific Research Institute of Vaccines and Serums of the Federal Medical-Biological Agency of Russia; others
Keywords: SARS-CoV-2, nucleocapsid, vaccine, immune response, primates
Summary of Study: Recombinant Nucleocapsid-Based Vaccine Convacell®
References: DOI: 10.3390/vaccines11040874
Contact Info: Sevastyan Rabdano: [email protected]
URL: https://www.mdpi.com/2076-393X/11/4/874
NHP Species: multiple species
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Federal Medical-Biological Agency of Russia, Moscow, Russia; Saint Petersburg Scientific Research Institute of Vaccines and Serums of the Federal Medical-Biological Agency of Russia; others
Keywords: SARS-CoV-2, nucleocapsid, vaccine, immune response, primates
Summary of Study: Recombinant Nucleocapsid-Based Vaccine Convacell®
References: DOI: 10.3390/vaccines11040874
Contact Info: Sevastyan Rabdano: [email protected]
URL: https://www.mdpi.com/2076-393X/11/4/874
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: therapeutics
NPRC/Institute: Oregon National Primate Research Center and numerous collaborators
Keywords: SARS-CoV-2, aerosol mAb, immune response, protection, primates
Summary of Study: Aerosol delivery of monoclonal antibodies limits viral replication and lung pathology
References: PMID: 37923717 PMCID: PMC10624670 DOI: 10.1038/s41467-023-42440-x
Contact Info: Nancy Haigwood: [email protected]
URL: https://www.nature.com/articles/s41467-023-42440-x
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: therapeutics
NPRC/Institute: Oregon National Primate Research Center and numerous collaborators
Keywords: SARS-CoV-2, aerosol mAb, immune response, protection, primates
Summary of Study: Aerosol delivery of monoclonal antibodies limits viral replication and lung pathology
References: PMID: 37923717 PMCID: PMC10624670 DOI: 10.1038/s41467-023-42440-x
Contact Info: Nancy Haigwood: [email protected]
URL: https://www.nature.com/articles/s41467-023-42440-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA, others
Keywords: SARS-CoV-2, intratracheal boosting, bivalent Ad26-based vaccine, immune response, primates
Summary of Study: Mucosal boosting enhances vaccine protection
References: PMID: 38096903 DOI: 10.1038/s41586-023-06951-3
Contact Info: Dan Barouch: [email protected]
URL: https://www.nature.com/articles/s41586-023-06951-3
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA, others
Keywords: SARS-CoV-2, intratracheal boosting, bivalent Ad26-based vaccine, immune response, primates
Summary of Study: Mucosal boosting enhances vaccine protection
References: PMID: 38096903 DOI: 10.1038/s41586-023-06951-3
Contact Info: Dan Barouch: [email protected]
URL: https://www.nature.com/articles/s41586-023-06951-3
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: The First Affiliated Hospital of Jinan University, Guangzhou 510630, China; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA USA
Keywords: SARS-CoV-2, favipiravir, biodistribution and pharmacokinetics, positron emission tomography, mice, primates
Summary of Study: Evaluating Favipiravir in rodents and nonhuman primates (NHP) with positron emission tomography
References: PMID: 37111280 / doi: 10.3390/ph16040524
Contact Info: Steven Liang: [email protected]
URL: https://www.mdpi.com/1424-8247/16/4/524
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: The First Affiliated Hospital of Jinan University, Guangzhou 510630, China; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA USA
Keywords: SARS-CoV-2, favipiravir, biodistribution and pharmacokinetics, positron emission tomography, mice, primates
Summary of Study: Evaluating Favipiravir in rodents and nonhuman primates (NHP) with positron emission tomography
References: PMID: 37111280 / doi: 10.3390/ph16040524
Contact Info: Steven Liang: [email protected]
URL: https://www.mdpi.com/1424-8247/16/4/524
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Virology and Immunology, Graduate School of Medicine, Osaka University, Osaka, 565-0871 Japan, others
Keywords: SARS-CoV-2, vaccine, Spike (S) receptor binding domain, immune response, primates
Summary of Study: saRNA vaccine expressing membrane-anchored RBD elicits broad and durable immunity
References: doi: 10.1038/s41467-023-38457-x
Contact Info: Takuya Yamamoto: [email protected]
URL: https://www.nature.com/articles/s41467-023-38457-x
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Virology and Immunology, Graduate School of Medicine, Osaka University, Osaka, 565-0871 Japan, others
Keywords: SARS-CoV-2, vaccine, Spike (S) receptor binding domain, immune response, primates
Summary of Study: saRNA vaccine expressing membrane-anchored RBD elicits broad and durable immunity
References: doi: 10.1038/s41467-023-38457-x
Contact Info: Takuya Yamamoto: [email protected]
URL: https://www.nature.com/articles/s41467-023-38457-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review: review
NPRC/Institute: Department de Sanitat i Anatomia Animals, Facultat de Veterinària, Campus de la UAB, Bellaterra, Spain; Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.; others
Keywords: SARS-CoV-2, review, animal models, neurological and neuropsychiatric symptoms, several species, primates
Summary of Study: Animal models to study neurological manifestations
References: DOI: 10.1038/s41684-023-01231-z
Contact Info: Joaquim Segalés: [email protected]
URL: https://www.nature.com/articles/s41684-023-01231-z
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review: review
NPRC/Institute: Department de Sanitat i Anatomia Animals, Facultat de Veterinària, Campus de la UAB, Bellaterra, Spain; Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.; others
Keywords: SARS-CoV-2, review, animal models, neurological and neuropsychiatric symptoms, several species, primates
Summary of Study: Animal models to study neurological manifestations
References: DOI: 10.1038/s41684-023-01231-z
Contact Info: Joaquim Segalés: [email protected]
URL: https://www.nature.com/articles/s41684-023-01231-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microbes and Infection, Fudan University, Shanghai, China
Keywords: SARS-CoV-2, fusion inhibitor, IgG-binding peptide, immune response, primates
Summary of Study: IgG Fc-Binding Peptide-Conjugated Pan-CoV Fusion Inhibitor Combined with Neutralizing Antibodies
References: DOI: 10.3390/biom13091283
Contact Info: Shibo Jiang:[email protected]; Shuai Xia: [email protected]
URL: https://www.mdpi.com/2218-273X/13/9/1283
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microbes and Infection, Fudan University, Shanghai, China
Keywords: SARS-CoV-2, fusion inhibitor, IgG-binding peptide, immune response, primates
Summary of Study: IgG Fc-Binding Peptide-Conjugated Pan-CoV Fusion Inhibitor Combined with Neutralizing Antibodies
References: DOI: 10.3390/biom13091283
Contact Info: Shibo Jiang:[email protected]; Shuai Xia: [email protected]
URL: https://www.mdpi.com/2218-273X/13/9/1283
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Novavax, Inc., Gaithersburg, MD, USA
Keywords: SARS-CoV-2, recombinant spike protein vaccine, immune response, mice, primates
Summary of Study: XBB.1.5 spike protein vaccine against EG.5.1 and emerging XBB variants
References: PMID: 37932354 PMCID: PMC10628164 DOI: 10.1038/s41598-023-46025-y
Contact Info: Gale Smith: [email protected]
URL: https://www.nature.com/articles/s41598-023-46025-y
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Novavax, Inc., Gaithersburg, MD, USA
Keywords: SARS-CoV-2, recombinant spike protein vaccine, immune response, mice, primates
Summary of Study: XBB.1.5 spike protein vaccine against EG.5.1 and emerging XBB variants
References: PMID: 37932354 PMCID: PMC10628164 DOI: 10.1038/s41598-023-46025-y
Contact Info: Gale Smith: [email protected]
URL: https://www.nature.com/articles/s41598-023-46025-y
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Core Unit of National Clinical Research Center for Laboratory Medicine Hefei Anhui P. R. China, others
Keywords: SARS-CoV-2, antibody response, immunological memory, long?term immune response, Omicron subvariants, primates
Summary of Study: Long-term immune response to Omicron-specific mRNA vaccination
References: PMID: 38107058 PMCID: PMC10724501 DOI: 10.1002/mco2.460
Contact Info: Wei Wang: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10724501/
NHP Species: multiple species
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Core Unit of National Clinical Research Center for Laboratory Medicine Hefei Anhui P. R. China, others
Keywords: SARS-CoV-2, antibody response, immunological memory, long?term immune response, Omicron subvariants, primates
Summary of Study: Long-term immune response to Omicron-specific mRNA vaccination
References: PMID: 38107058 PMCID: PMC10724501 DOI: 10.1002/mco2.460
Contact Info: Wei Wang: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10724501/
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Wayne State University, Detroit, Michigan, Center for Comparative Medicine, Massachusetts General Hospital, Boston, Massachusetts, Division of Animal Resources, University of Illinois at Urbana-Champaign, Champaign, Illinois
Keywords: SARS-CoV-2, review, neurological symptoms, humans, mice, hamsters, ferrets, primates
Summary of Study: Animal Models for the Study of Neurologic Manifestations Of COVID-19
References: doi: 10.30802/AALAS-CM-22-000073
Contact Info: Kelsey Carpenter: [email protected]
URL: https://aalas.kglmeridian.com/view/journals/72010023/73/1/article-p91.xml
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Wayne State University, Detroit, Michigan, Center for Comparative Medicine, Massachusetts General Hospital, Boston, Massachusetts, Division of Animal Resources, University of Illinois at Urbana-Champaign, Champaign, Illinois
Keywords: SARS-CoV-2, review, neurological symptoms, humans, mice, hamsters, ferrets, primates
Summary of Study: Animal Models for the Study of Neurologic Manifestations Of COVID-19
References: doi: 10.30802/AALAS-CM-22-000073
Contact Info: Kelsey Carpenter: [email protected]
URL: https://aalas.kglmeridian.com/view/journals/72010023/73/1/article-p91.xml
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Massachusetts General Hospital, Charlestown, Massachusetts USA; Brigham and Women's Hospital, Boston, Massachusetts, and others
Keywords: SARS-CoV-2, review, brain autopsies, neuropathological findings, humans, animal models, primates
Summary of Study: Review: What Can We Still Learn from Brain Autopsies in COVID-19?
References: PMID: 37023787 / doi: 10.1055/s-0043-1767716
Contact Info: Shibani Mukerji: [email protected]
URL: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-17677…
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Massachusetts General Hospital, Charlestown, Massachusetts USA; Brigham and Women's Hospital, Boston, Massachusetts, and others
Keywords: SARS-CoV-2, review, brain autopsies, neuropathological findings, humans, animal models, primates
Summary of Study: Review: What Can We Still Learn from Brain Autopsies in COVID-19?
References: PMID: 37023787 / doi: 10.1055/s-0043-1767716
Contact Info: Shibani Mukerji: [email protected]
URL: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-17677…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, 200438, China., many others
Keywords: SARS-CoV-2, vaccine, mRNA-based T-cell-inducing antigen, immune response, primates
Summary of Study: mRNA-based T-cell-inducing antigen strengthens COVID-19 vaccine
References: doi: 10.1038/s41467-023-38751-8
Contact Info: Jinzhong Lin: [email protected]
URL: https://www.nature.com/articles/s41467-023-38751-8
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, 200438, China., many others
Keywords: SARS-CoV-2, vaccine, mRNA-based T-cell-inducing antigen, immune response, primates
Summary of Study: mRNA-based T-cell-inducing antigen strengthens COVID-19 vaccine
References: doi: 10.1038/s41467-023-38751-8
Contact Info: Jinzhong Lin: [email protected]
URL: https://www.nature.com/articles/s41467-023-38751-8
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: prevention
NPRC/Institute: Graduate School of Medicine and Veterinary Medicine, University of Miyazaki, Miyazaki, 889-2155, Japan; Laboratory of Immunoregulation and Vaccine Research, Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Tsukuba, 305-0843, Japan.; others
Keywords: SARS-CoV-2, ACE2 decoy, immune response, pathology, mice, hamsters, primates
Summary of Study: Inhaled ACE2 decoy confers protection
References: DOI: 10.1126/scitranslmed.adi2623
Contact Info: Atsushi Hoshino: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.adi2623
NHP Species:
Year Published: 2023
Study Type/Review: prevention
NPRC/Institute: Graduate School of Medicine and Veterinary Medicine, University of Miyazaki, Miyazaki, 889-2155, Japan; Laboratory of Immunoregulation and Vaccine Research, Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Tsukuba, 305-0843, Japan.; others
Keywords: SARS-CoV-2, ACE2 decoy, immune response, pathology, mice, hamsters, primates
Summary of Study: Inhaled ACE2 decoy confers protection
References: DOI: 10.1126/scitranslmed.adi2623
Contact Info: Atsushi Hoshino: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.adi2623
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Executive Office, Shanghai BravoBio Co., Ltd., Shanghai, China; BravoVax Co., Ltd., Wuhan, China
Keywords: SARS-CoV-2, adenovirus vaccine, aerosol inhalation, immune response, primates
Summary of Study: Aerosol Inhalation of Chimpanzee Adenovirus Vectors (ChAd68) Expressing Ancestral or Omicron BA.1 Stabilized Pre-Fusion Spike Glycoproteins
References: DOI: 10.3390/vaccines11091427
Contact Info: Ke Wu: [email protected]
URL: https://www.mdpi.com/2076-393X/11/9/1427
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Executive Office, Shanghai BravoBio Co., Ltd., Shanghai, China; BravoVax Co., Ltd., Wuhan, China
Keywords: SARS-CoV-2, adenovirus vaccine, aerosol inhalation, immune response, primates
Summary of Study: Aerosol Inhalation of Chimpanzee Adenovirus Vectors (ChAd68) Expressing Ancestral or Omicron BA.1 Stabilized Pre-Fusion Spike Glycoproteins
References: DOI: 10.3390/vaccines11091427
Contact Info: Ke Wu: [email protected]
URL: https://www.mdpi.com/2076-393X/11/9/1427
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Cognitive and Neural Science Program, Department of Psychology, University of South Carolina, Columbia, SC, 29208, USA; others
Keywords: SARS-CoV-2, nervous system, pathophysiology, virus persistence, primates
Summary of Study: Viral persistence in central nervous system despite clinical recovery
References: PMID: 37934362 PMCID: PMC10630293 DOI: 10.1186/s43556-023-00153-z
Contact Info: Rosemarie Booze: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630293/
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Cognitive and Neural Science Program, Department of Psychology, University of South Carolina, Columbia, SC, 29208, USA; others
Keywords: SARS-CoV-2, nervous system, pathophysiology, virus persistence, primates
Summary of Study: Viral persistence in central nervous system despite clinical recovery
References: PMID: 37934362 PMCID: PMC10630293 DOI: 10.1186/s43556-023-00153-z
Contact Info: Rosemarie Booze: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630293/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: NIAID, NIH, Bethesda, MD 20892, USA.
Keywords: SARS-CoV-2, murine pneumonia virus-vectored vaccine, immune response, primates
Summary of Study: Intranasal murine pneumonia virus-vectored vaccine induces mucosal and serum antibodies
References: PMID: 38144450 PMCID: PMC10746510 DOI: 10.1016/j.isci.2023.108490
Contact Info: Ursula Buchholz: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2589004223025671?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: NIAID, NIH, Bethesda, MD 20892, USA.
Keywords: SARS-CoV-2, murine pneumonia virus-vectored vaccine, immune response, primates
Summary of Study: Intranasal murine pneumonia virus-vectored vaccine induces mucosal and serum antibodies
References: PMID: 38144450 PMCID: PMC10746510 DOI: 10.1016/j.isci.2023.108490
Contact Info: Ursula Buchholz: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2589004223025671?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: lemurs
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Department of Pharmacy, Faculty of Health Sciences, Universidad Cardenal Herrera-CEU, 46113 Valencia, Spain; others
Keywords: SARS-CoV-2, captive animals, one health, serological testing, primates
Summary of Study: Molecular and serological studies
References: PMID: 38200871 PMCID: PMC10778278 DOI: 10.3390/ani14010140
Contact Info: Consuelo Rubio-Guerri: [email protected]
URL: https://www.mdpi.com/2076-2615/14/1/140
NHP Species: lemurs
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Department of Pharmacy, Faculty of Health Sciences, Universidad Cardenal Herrera-CEU, 46113 Valencia, Spain; others
Keywords: SARS-CoV-2, captive animals, one health, serological testing, primates
Summary of Study: Molecular and serological studies
References: PMID: 38200871 PMCID: PMC10778278 DOI: 10.3390/ani14010140
Contact Info: Consuelo Rubio-Guerri: [email protected]
URL: https://www.mdpi.com/2076-2615/14/1/140
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Tulane NPRC; Duke University Medical Center
Keywords: SARS-CoV-2, prophylactic administration, convalescent plasma, disease progression and severity, primates
Summary of Study: Convalescent plasma administration results in suboptimal prophylaxis against SARS-CoV-2 infection
References: doi: 10.3389/fimmu.2023.1085883
Contact Info: Chad Roy: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1085883/full
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Tulane NPRC; Duke University Medical Center
Keywords: SARS-CoV-2, prophylactic administration, convalescent plasma, disease progression and severity, primates
Summary of Study: Convalescent plasma administration results in suboptimal prophylaxis against SARS-CoV-2 infection
References: doi: 10.3389/fimmu.2023.1085883
Contact Info: Chad Roy: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1085883/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Emory University, Emory National Primate Research Center, others
Keywords: SARS-CoV-2, innate immune system, airway inflammation, humans, primates
Summary of Study: TREM2+ and interstitial-like macrophages orchestrate airway inflammation
References: PMID: 37024448 / doi: 10.1038/s41467-023-37425-9
Contact Info: Mirko Paiardini: [email protected]
URL: https://www.nature.com/articles/s41467-023-37425-9
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Emory University, Emory National Primate Research Center, others
Keywords: SARS-CoV-2, innate immune system, airway inflammation, humans, primates
Summary of Study: TREM2+ and interstitial-like macrophages orchestrate airway inflammation
References: PMID: 37024448 / doi: 10.1038/s41467-023-37425-9
Contact Info: Mirko Paiardini: [email protected]
URL: https://www.nature.com/articles/s41467-023-37425-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Shulan International Medical College, Zhejiang Shuren University, Hangzhou, 310000, China, others
Keywords: SARS-CoV-2, inactivated vaccine, immune response, primates
Summary of Study: Delta (B.1.617.2) inactivated vaccine candidate elicits neutralizing antibodies
References: doi: 10.1016/j.virs.2023.05.009
Contact Info: Keda Chen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1995820X23000573?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Shulan International Medical College, Zhejiang Shuren University, Hangzhou, 310000, China, others
Keywords: SARS-CoV-2, inactivated vaccine, immune response, primates
Summary of Study: Delta (B.1.617.2) inactivated vaccine candidate elicits neutralizing antibodies
References: doi: 10.1016/j.virs.2023.05.009
Contact Info: Keda Chen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1995820X23000573?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: KRIBB School of Bioscience, Korea University of Science & Technology (UST), Daejeon, Republic of Korea; National Primate Research Centre, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Chungcheongbuk, Republic of Korea.; others
Keywords: SARS-CoV-2, spatial transcriptome atlas, lungs, immune response, primates
Summary of Study: Pulmonary microstructure-specific COVID-19 gene signatures
References: DOI: 10.1038/s42003-023-05253-8
Contact Info: Jung Joo Hong: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462721/
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: KRIBB School of Bioscience, Korea University of Science & Technology (UST), Daejeon, Republic of Korea; National Primate Research Centre, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Chungcheongbuk, Republic of Korea.; others
Keywords: SARS-CoV-2, spatial transcriptome atlas, lungs, immune response, primates
Summary of Study: Pulmonary microstructure-specific COVID-19 gene signatures
References: DOI: 10.1038/s42003-023-05253-8
Contact Info: Jung Joo Hong: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462721/
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: University of South Carolina; Tulane National Primate Research Center
Keywords: SARS-CoV-2, brain, pathology, in situ hybridization, primates
Summary of Study: SARS-CoV-2 RNA Persists in the Central Nervous System despite clinical recovery
References: DOI: 10.1101/2023.08.29.555368
Contact Info: Rosemarie Booze: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491216/
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: University of South Carolina; Tulane National Primate Research Center
Keywords: SARS-CoV-2, brain, pathology, in situ hybridization, primates
Summary of Study: SARS-CoV-2 RNA Persists in the Central Nervous System despite clinical recovery
References: DOI: 10.1101/2023.08.29.555368
Contact Info: Rosemarie Booze: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491216/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD 20892, USA; others
Keywords: SARS-CoV-2, Adenoviral-vectored Vaccine Boosting, immune response, primates
Summary of Study: Mucosal adenoviral-vectored vaccine boosting prevents XBB.1.16 infection
References: bioRxiv. 2023 Nov 8:2023.11.06.565765. doi: 10.1101/2023.11.06.565765. Preprint. PMID: 37986823 PMCID: PMC10659340 DOI: 10.1101/2023.11.06.565765
Contact Info: Daniel Douek: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.11.06.565765v1
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD 20892, USA; others
Keywords: SARS-CoV-2, Adenoviral-vectored Vaccine Boosting, immune response, primates
Summary of Study: Mucosal adenoviral-vectored vaccine boosting prevents XBB.1.16 infection
References: bioRxiv. 2023 Nov 8:2023.11.06.565765. doi: 10.1101/2023.11.06.565765. Preprint. PMID: 37986823 PMCID: PMC10659340 DOI: 10.1101/2023.11.06.565765
Contact Info: Daniel Douek: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.11.06.565765v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Shanghai Institute for Advanced Immunochemical Studies, School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510300, P. R. China, many others
Keywords: SARS-CoV-2, mosaic RBD nanoparticle vaccine, immune response, primates
Summary of Study: Mosaic RBD nanoparticles elicit protective immunity
References: PMID: 38105421 DOI: 10.1002/advs.202303366
Contact Info: Jincun Zhao: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10916629/
NHP Species: cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Shanghai Institute for Advanced Immunochemical Studies, School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510300, P. R. China, many others
Keywords: SARS-CoV-2, mosaic RBD nanoparticle vaccine, immune response, primates
Summary of Study: Mosaic RBD nanoparticles elicit protective immunity
References: PMID: 38105421 DOI: 10.1002/advs.202303366
Contact Info: Jincun Zhao: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10916629/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School, Boston, MA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA; numerous others
Keywords: SARS-CoV-2, immunogenicity and protective efficacy, subunit vaccine, virus strains, primates
Summary of Study: Immunogenicity and protective efficacy of GBP510/AS03 vaccine
References: doi: 10.1038/s41541-023-00622-0
Contact Info: Dan Barouch: [email protected]
URL: https://www.nature.com/articles/s41541-023-00622-0
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School, Boston, MA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA; numerous others
Keywords: SARS-CoV-2, immunogenicity and protective efficacy, subunit vaccine, virus strains, primates
Summary of Study: Immunogenicity and protective efficacy of GBP510/AS03 vaccine
References: doi: 10.1038/s41541-023-00622-0
Contact Info: Dan Barouch: [email protected]
URL: https://www.nature.com/articles/s41541-023-00622-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Massachusetts Consortium on Pathogen Readiness, Boston, MA USA and others
Keywords: SARS-CoV-2, omicron spike protein encoding vaccine, boosters, immune response, primates
Summary of Study: Booster with Ad26.COV2.S or Omicron-adapted vaccine enhanced immunity and efficacy
References: PMID: 37029141 / 10.1038/s41467-023-37715-2
Contact Info: Frank Wegmann: [email protected]
URL: https://www.nature.com/articles/s41467-023-37715-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Massachusetts Consortium on Pathogen Readiness, Boston, MA USA and others
Keywords: SARS-CoV-2, omicron spike protein encoding vaccine, boosters, immune response, primates
Summary of Study: Booster with Ad26.COV2.S or Omicron-adapted vaccine enhanced immunity and efficacy
References: PMID: 37029141 / 10.1038/s41467-023-37715-2
Contact Info: Frank Wegmann: [email protected]
URL: https://www.nature.com/articles/s41467-023-37715-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Sanofi, Vaccines R&D, Marcy l'Etoile, France, and others
Keywords: SARS-CoV-2, bivalent vaccine, virus variants, immune response, primates
Summary of Study: Beta-containing bivalent SARS-CoV-2 protein vaccine elicits durable broad neutralization
References: doi: 10.1038/s43856-023-00302-z
Contact Info: Valerie Lecouturier: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212738/
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Sanofi, Vaccines R&D, Marcy l'Etoile, France, and others
Keywords: SARS-CoV-2, bivalent vaccine, virus variants, immune response, primates
Summary of Study: Beta-containing bivalent SARS-CoV-2 protein vaccine elicits durable broad neutralization
References: doi: 10.1038/s43856-023-00302-z
Contact Info: Valerie Lecouturier: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212738/
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Faculty of Mathematics and Natural Sciences, University of Greifswald, Greifswald, Germany; Institute of Immunology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany; others
Keywords: SARS-CoV-2, review, tuberculosis, pathogenesis, several species, primates
Summary of Study: Animal models for COVID-19 and tuberculosis
References: DOI: 10.3389/fimmu.2023.1223260
Contact Info: Björn Corleis: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1223260/full
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Faculty of Mathematics and Natural Sciences, University of Greifswald, Greifswald, Germany; Institute of Immunology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany; others
Keywords: SARS-CoV-2, review, tuberculosis, pathogenesis, several species, primates
Summary of Study: Animal models for COVID-19 and tuberculosis
References: DOI: 10.3389/fimmu.2023.1223260
Contact Info: Björn Corleis: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1223260/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: West China Hospital Sichuan University Chengdu China; Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu Sichuan China; others
Keywords: SARS-CoV-2, spheroid-embryonoid stem cells, viral variants, immune response, primates
Summary of Study: 3D-engineered multifunctional biologics to reverse immune system evasion
References: DOI: 10.1002/btm2.10554
Contact Info: Xiancheng Chen: [email protected]
URL: https://aiche.onlinelibrary.wiley.com/doi/full/10.1002/btm2.10554
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: West China Hospital Sichuan University Chengdu China; Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu Sichuan China; others
Keywords: SARS-CoV-2, spheroid-embryonoid stem cells, viral variants, immune response, primates
Summary of Study: 3D-engineered multifunctional biologics to reverse immune system evasion
References: DOI: 10.1002/btm2.10554
Contact Info: Xiancheng Chen: [email protected]
URL: https://aiche.onlinelibrary.wiley.com/doi/full/10.1002/btm2.10554
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Frederick National Laboratory for Cancer Research, Frederick, MD, USA; others
Keywords: SARS-CoV-2, machine-learning, radiomics, biomarkers, immune response, disease progression, primates
Summary of Study: Novel machine-learning analysis of infection using radiomics and blood biomarkers
References: PMID: 37950044 PMCID: PMC10638262 DOI: 10.1038/s41598-023-46694-9
Contact Info: Jeffrey Solomon: [email protected]
URL: https://www.nature.com/articles/s41598-023-46694-9
NHP Species: cynomolgus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Frederick National Laboratory for Cancer Research, Frederick, MD, USA; others
Keywords: SARS-CoV-2, machine-learning, radiomics, biomarkers, immune response, disease progression, primates
Summary of Study: Novel machine-learning analysis of infection using radiomics and blood biomarkers
References: PMID: 37950044 PMCID: PMC10638262 DOI: 10.1038/s41598-023-46694-9
Contact Info: Jeffrey Solomon: [email protected]
URL: https://www.nature.com/articles/s41598-023-46694-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: University of Bremen, Bremen, Germany and others
Keywords: SARS-CoV-2, mRNA vaccination, elderly animals, immune response, primates
Summary of Study: Monitoring vaccination in laboratory rhesus monkeys
References: doi: 10.1038/s41598-023-30473-7
Contact Info: Detlef Wegener: [email protected]
URL: https://www.nature.com/articles/s41598-023-30473-7
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: University of Bremen, Bremen, Germany and others
Keywords: SARS-CoV-2, mRNA vaccination, elderly animals, immune response, primates
Summary of Study: Monitoring vaccination in laboratory rhesus monkeys
References: doi: 10.1038/s41598-023-30473-7
Contact Info: Detlef Wegener: [email protected]
URL: https://www.nature.com/articles/s41598-023-30473-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Chan Zuckerberg Biohub, Stanford University, others
Keywords: SARS-CoV-2, ferritin-based, protein-nanoparticle vaccine, immune response, virus variants, primates
Summary of Study: Ferritin-based nanoparticle vaccine
References: PMID: 37069151 / doi: 10.1038/s41467-023-37417-9
Contact Info: Peter S Kim: [email protected]
URL: https://www.nature.com/articles/s41467-023-37417-9
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Chan Zuckerberg Biohub, Stanford University, others
Keywords: SARS-CoV-2, ferritin-based, protein-nanoparticle vaccine, immune response, virus variants, primates
Summary of Study: Ferritin-based nanoparticle vaccine
References: PMID: 37069151 / doi: 10.1038/s41467-023-37417-9
Contact Info: Peter S Kim: [email protected]
URL: https://www.nature.com/articles/s41467-023-37417-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland
Keywords: SARS-CoV-2, vaccine, immune response, primates
Summary of Study: Humoral immunogenicity of DNA vaccine delivered using needle-free jet injection
References: Doi: 10.1371/journal.pone.0275082
Contact Info: Jay Hooper: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0275082
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland
Keywords: SARS-CoV-2, vaccine, immune response, primates
Summary of Study: Humoral immunogenicity of DNA vaccine delivered using needle-free jet injection
References: Doi: 10.1371/journal.pone.0275082
Contact Info: Jay Hooper: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0275082
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: SingHealth Duke-NUS Global Health Institute, Singapore; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore; others
Keywords: SARS-CoV-2, mast cells, lungs, pathology, mice, primates, humans.
Summary of Study: Mast cell activation in lungs and severe COVID-19
References: DOI: 10.1172/JCI149834
Contact Info: Ashley L. St. John: [email protected]
URL: https://www.jci.org/articles/view/149834
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: SingHealth Duke-NUS Global Health Institute, Singapore; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore; others
Keywords: SARS-CoV-2, mast cells, lungs, pathology, mice, primates, humans.
Summary of Study: Mast cell activation in lungs and severe COVID-19
References: DOI: 10.1172/JCI149834
Contact Info: Ashley L. St. John: [email protected]
URL: https://www.jci.org/articles/view/149834
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Intelligence & Technology Lab, Inc., Kaizu, Japan; Innovation Research Center, EPS Holdings, Inc., Tokyo, Japan.
Keywords: SARS-CoV-2, sublingual vaccine, receptor binding domain, immune response, primates
Summary of Study: sublingual vaccine with RBD antigen and poly(I:C) adjuvant
References: DOI: 10.1093/biomethods/bpad017
Contact Info: Shin Nakamura: [email protected]
URL: https://academic.oup.com/biomethods/article/8/1/bpad017/7266774
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Intelligence & Technology Lab, Inc., Kaizu, Japan; Innovation Research Center, EPS Holdings, Inc., Tokyo, Japan.
Keywords: SARS-CoV-2, sublingual vaccine, receptor binding domain, immune response, primates
Summary of Study: sublingual vaccine with RBD antigen and poly(I:C) adjuvant
References: DOI: 10.1093/biomethods/bpad017
Contact Info: Shin Nakamura: [email protected]
URL: https://academic.oup.com/biomethods/article/8/1/bpad017/7266774
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai 200438, China; Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200438, China; Zhangjiang mRNA Innovation and Translation Center, Fudan University, Shanghai 200438, China; others
Keywords: SARS-CoV-2, mRNA vaccine, chimeric spike protein, immunogenicity, primates
Summary of Study: RQ3013, a broad-spectrum mRNA vaccine against variants
References: PMID: 37993332 DOI: 10.1016/j.scib.2023.11.024
Contact Info: Jinzhong Lin: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2095927323007788?via%3Dihub
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai 200438, China; Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200438, China; Zhangjiang mRNA Innovation and Translation Center, Fudan University, Shanghai 200438, China; others
Keywords: SARS-CoV-2, mRNA vaccine, chimeric spike protein, immunogenicity, primates
Summary of Study: RQ3013, a broad-spectrum mRNA vaccine against variants
References: PMID: 37993332 DOI: 10.1016/j.scib.2023.11.024
Contact Info: Jinzhong Lin: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2095927323007788?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: University of Maryland School of Medicine, Baltimore, MD, others
Keywords: SARS-CoV-2, recombinant vaccine, immune response, virus variants, mice, primates
Summary of Study: Recombinant prefusion-stabilized spike (rS) protein vaccine based on Beta/B.1.351 (rS-Beta) produces robust anamnestic response
References: doi: 10.1038/s41467-022-35606-6
Contact Info: Matthew Freiman: [email protected]
URL: https://www.nature.com/articles/s41467-022-35606-6
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: University of Maryland School of Medicine, Baltimore, MD, others
Keywords: SARS-CoV-2, recombinant vaccine, immune response, virus variants, mice, primates
Summary of Study: Recombinant prefusion-stabilized spike (rS) protein vaccine based on Beta/B.1.351 (rS-Beta) produces robust anamnestic response
References: doi: 10.1038/s41467-022-35606-6
Contact Info: Matthew Freiman: [email protected]
URL: https://www.nature.com/articles/s41467-022-35606-6
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School, Boston, MA, USA; Beth Israel Deaconess Medical Center, Boston, MA, USA, others
Keywords: SARS-CoV-2, immunogenicity and protective efficacy, Ad26.COV2.S vaccine, primates
Summary of Study: Spike protein ferritin nanoparticle vaccine
References: PMID: 37023746 / doi: 10.1016/j.xcrm.2023.101018
Contact Info: Dan Barouch: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379123001283?via%3Dihub
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School, Boston, MA, USA; Beth Israel Deaconess Medical Center, Boston, MA, USA, others
Keywords: SARS-CoV-2, immunogenicity and protective efficacy, Ad26.COV2.S vaccine, primates
Summary of Study: Spike protein ferritin nanoparticle vaccine
References: PMID: 37023746 / doi: 10.1016/j.xcrm.2023.101018
Contact Info: Dan Barouch: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379123001283?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine, Tulane National Primate Research Center, others
Keywords: SARS-CoV-2, CSF, neuropathology, proteomics, mass-spectrometry, primates
Summary of Study: Cerebrospinal Fluid Protein Markers Indicate Neuro-Damage in SARS-CoV-2-Infected Nonhuman Primates.
References: DOI: 10.1016/j.mcpro.2023.100523
Contact Info: Jia Fan: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981268/
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine, Tulane National Primate Research Center, others
Keywords: SARS-CoV-2, CSF, neuropathology, proteomics, mass-spectrometry, primates
Summary of Study: Cerebrospinal Fluid Protein Markers Indicate Neuro-Damage in SARS-CoV-2-Infected Nonhuman Primates.
References: DOI: 10.1016/j.mcpro.2023.100523
Contact Info: Jia Fan: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981268/
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Vaccine Research Institute, Créteil, France; Université Paris Cité, IAME, Inserm, Paris, France; others
Keywords: SARS-CoV-2, mathematical model, viral dynamic, primates
Summary of Study: Impact of variants of concern on SARS-CoV-2 viral dynamics
References: DOI: 10.1371/journal.pcbi.1010721
Contact Info: Aurélien Marc: [email protected]
URL: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1010721
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Vaccine Research Institute, Créteil, France; Université Paris Cité, IAME, Inserm, Paris, France; others
Keywords: SARS-CoV-2, mathematical model, viral dynamic, primates
Summary of Study: Impact of variants of concern on SARS-CoV-2 viral dynamics
References: DOI: 10.1371/journal.pcbi.1010721
Contact Info: Aurélien Marc: [email protected]
URL: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1010721
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: National Institutes of Health, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
Keywords: SARS-CoV-2, attenuated murine pneumonia virus vector, vaccine immune response, primates
Summary of Study: Mucosal prime-boost immunization with live murine pneumonia virus-vectored vaccine
References: DOI: 10.21203/rs.3.rs-3278289/v1
Contact Info: Ursula Buchholz: [email protected]
URL: https://www.researchsquare.com/article/rs-3278289/v1
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: National Institutes of Health, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
Keywords: SARS-CoV-2, attenuated murine pneumonia virus vector, vaccine immune response, primates
Summary of Study: Mucosal prime-boost immunization with live murine pneumonia virus-vectored vaccine
References: DOI: 10.21203/rs.3.rs-3278289/v1
Contact Info: Ursula Buchholz: [email protected]
URL: https://www.researchsquare.com/article/rs-3278289/v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Tulane National Primate Research Center, Covington, Louisiana; others
Keywords: SARS-CoV-2, SIV-Induced Immunodeficiency, immune response, coinfection, primates
Summary of Study: Impact of SIV-Induced Immunodeficiency on Clinical Manifestation, Immune Response, and Viral Dynamics in SARS-CoV-2 Coinfection
References: bioRxiv.2023 Nov 16:2023.11.15.567132. doi: 10.1101/2023.11.15.567132. Preprint. PMID: 38014096 PMCID: PMC10680717 DOI: 10.1101/2023.11.15.567132
Contact Info: Nicholas Maness: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.11.15.567132v1
NHP Species: pigtail macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Tulane National Primate Research Center, Covington, Louisiana; others
Keywords: SARS-CoV-2, SIV-Induced Immunodeficiency, immune response, coinfection, primates
Summary of Study: Impact of SIV-Induced Immunodeficiency on Clinical Manifestation, Immune Response, and Viral Dynamics in SARS-CoV-2 Coinfection
References: bioRxiv.2023 Nov 16:2023.11.15.567132. doi: 10.1101/2023.11.15.567132. Preprint. PMID: 38014096 PMCID: PMC10680717 DOI: 10.1101/2023.11.15.567132
Contact Info: Nicholas Maness: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.11.15.567132v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Beijing Engineering Research Center of Protein and Antibody, Sinocelltech Ltd., Beijing, China; Cell Culture Engineering Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Keywords: SARS-CoV-2, nanoparticle vaccine, immunogenicity, toxicity, primates
Summary of Study: COVID-19 vaccine showed high immunogenicity and low toxicity in animal models
References: doi: 10.3390/vaccines11030526
Contact Info: Liangzhi Xie: [email protected]
URL: https://www.mdpi.com/2076-393X/11/3/526
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Beijing Engineering Research Center of Protein and Antibody, Sinocelltech Ltd., Beijing, China; Cell Culture Engineering Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Keywords: SARS-CoV-2, nanoparticle vaccine, immunogenicity, toxicity, primates
Summary of Study: COVID-19 vaccine showed high immunogenicity and low toxicity in animal models
References: doi: 10.3390/vaccines11030526
Contact Info: Liangzhi Xie: [email protected]
URL: https://www.mdpi.com/2076-393X/11/3/526
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: University of Washington, Seattle, Washington USA; HDT Bio, Washington National Primate Research Center, others
Keywords: SARS-CoV-2, replicon RNA vaccine, immune response and protection, primates
Summary of Study: Replicon RNA vaccine for durable protective immunity
References: PMID: 37075079 / doi: 10.1371/journal.ppat.1011298
Contact Info: Jesse Erasmus: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011298
NHP Species: pigtail macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: University of Washington, Seattle, Washington USA; HDT Bio, Washington National Primate Research Center, others
Keywords: SARS-CoV-2, replicon RNA vaccine, immune response and protection, primates
Summary of Study: Replicon RNA vaccine for durable protective immunity
References: PMID: 37075079 / doi: 10.1371/journal.ppat.1011298
Contact Info: Jesse Erasmus: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011298
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, China; others
Keywords: SARS-CoV-2, inactivated vaccine, immune response, primates
Summary of Study: Preclinical safety evaluation of intradermal SARS-CoV-2 inactivated vaccine (Vero cells) administration in macaques.
References: DOI: 10.1016/j.vaccine.2023.03.033
Contact Info: Qihan Li: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003171?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, China; others
Keywords: SARS-CoV-2, inactivated vaccine, immune response, primates
Summary of Study: Preclinical safety evaluation of intradermal SARS-CoV-2 inactivated vaccine (Vero cells) administration in macaques.
References: DOI: 10.1016/j.vaccine.2023.03.033
Contact Info: Qihan Li: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003171?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Molecular Genetics, University of Toronto; Toronto, Canada; Icosagen Cell Factory OÜ; Tartu, Estonia; others
Keywords: SARS-CoV-2, humanized antibodies, immune response, vaccine, primates
Summary of Study: bnAb protection through inhalation-based delivery
References: DOI: 10.1371/journal.ppat.1011532
Contact Info: Mart Ustav, Jr.: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011532
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Molecular Genetics, University of Toronto; Toronto, Canada; Icosagen Cell Factory OÜ; Tartu, Estonia; others
Keywords: SARS-CoV-2, humanized antibodies, immune response, vaccine, primates
Summary of Study: bnAb protection through inhalation-based delivery
References: DOI: 10.1371/journal.ppat.1011532
Contact Info: Mart Ustav, Jr.: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011532
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Center for Genetic Engineering and Biotechnology, Production Division, Havana, Cuba
Keywords: SARS-CoV-2, chimeric antigen, vaccine, immune response, mice, primates
Summary of Study: chimeric antigen, based on nucleocapsid of SARS-CoV-2 fused to the extracellular domain of human CD154 in HEK-293 cells
References: DOI: 10.1371/journal.pone.0288006
Contact Info: Mario Pablo Estrada: [email protected]; Yamila Carpio: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0288006
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Center for Genetic Engineering and Biotechnology, Production Division, Havana, Cuba
Keywords: SARS-CoV-2, chimeric antigen, vaccine, immune response, mice, primates
Summary of Study: chimeric antigen, based on nucleocapsid of SARS-CoV-2 fused to the extracellular domain of human CD154 in HEK-293 cells
References: DOI: 10.1371/journal.pone.0288006
Contact Info: Mario Pablo Estrada: [email protected]; Yamila Carpio: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0288006
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Gwanak-gu, Seoul, 08826, Republic of Korea; others
Keywords: SARS-CoV-2, pulmonary lesions, histopathology, primates
Summary of Study: Histopathological pulmonary lesions in SARS-CoV-2
References: PMID: 38007889 DOI: 10.1016/j.jcpa.2023.10.008
Contact Info: Jae-Hak Park: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0021997523002967?via%3Dihub
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Gwanak-gu, Seoul, 08826, Republic of Korea; others
Keywords: SARS-CoV-2, pulmonary lesions, histopathology, primates
Summary of Study: Histopathological pulmonary lesions in SARS-CoV-2
References: PMID: 38007889 DOI: 10.1016/j.jcpa.2023.10.008
Contact Info: Jae-Hak Park: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0021997523002967?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Duke University School of Medicine, Durham, NC; others
Keywords: SARS-CoV-2, spike protein, mRNA vaccine, immune response, virus variants, conserved epitopes, primates
Summary of Study: Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination
References: bioRxiv PMID: 38187726 PMCID: PMC10769253 DOI: 10.1101/2023.12.18.572191
Contact Info: Kevin O. Saunders: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.12.18.572191v1
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Duke University School of Medicine, Durham, NC; others
Keywords: SARS-CoV-2, spike protein, mRNA vaccine, immune response, virus variants, conserved epitopes, primates
Summary of Study: Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination
References: bioRxiv PMID: 38187726 PMCID: PMC10769253 DOI: 10.1101/2023.12.18.572191
Contact Info: Kevin O. Saunders: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.12.18.572191v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland; Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Mary
Keywords: SARS-CoV-2, deep learning, computerized tomography, lung lesions, primates
Summary of Study: Modeling whole lung and lung lesions to detect and quantify disease
References: doi: 10.1016/j.acra.2023.02.027
Contact Info: [email protected]
URL: https://pubmed.ncbi.nlm.nih.gov/36966070/
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland; Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Mary
Keywords: SARS-CoV-2, deep learning, computerized tomography, lung lesions, primates
Summary of Study: Modeling whole lung and lung lesions to detect and quantify disease
References: doi: 10.1016/j.acra.2023.02.027
Contact Info: [email protected]
URL: https://pubmed.ncbi.nlm.nih.gov/36966070/