Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Emory University, Emory National Primate Research Center, others
Keywords: SARS-CoV-2, innate immune system, airway inflammation, humans, primates
Summary of Study: TREM2+ and interstitial-like macrophages orchestrate airway inflammation
References: PMID: 37024448 / doi: 10.1038/s41467-023-37425-9
Contact Info: Mirko Paiardini: mirko.paiardini@emory.edu
URL: https://www.nature.com/articles/s41467-023-37425-9
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Emory University, Emory National Primate Research Center, others
Keywords: SARS-CoV-2, innate immune system, airway inflammation, humans, primates
Summary of Study: TREM2+ and interstitial-like macrophages orchestrate airway inflammation
References: PMID: 37024448 / doi: 10.1038/s41467-023-37425-9
Contact Info: Mirko Paiardini: mirko.paiardini@emory.edu
URL: https://www.nature.com/articles/s41467-023-37425-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Shulan International Medical College, Zhejiang Shuren University, Hangzhou, 310000, China, others
Keywords: SARS-CoV-2, inactivated vaccine, immune response, primates
Summary of Study: Delta (B.1.617.2) inactivated vaccine candidate elicits neutralizing antibodies
References: doi: 10.1016/j.virs.2023.05.009
Contact Info: Keda Chen: chenkd@zjsru.edu.cn
URL: https://www.sciencedirect.com/science/article/pii/S1995820X23000573?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Shulan International Medical College, Zhejiang Shuren University, Hangzhou, 310000, China, others
Keywords: SARS-CoV-2, inactivated vaccine, immune response, primates
Summary of Study: Delta (B.1.617.2) inactivated vaccine candidate elicits neutralizing antibodies
References: doi: 10.1016/j.virs.2023.05.009
Contact Info: Keda Chen: chenkd@zjsru.edu.cn
URL: https://www.sciencedirect.com/science/article/pii/S1995820X23000573?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: KRIBB School of Bioscience, Korea University of Science & Technology (UST), Daejeon, Republic of Korea; National Primate Research Centre, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Chungcheongbuk, Republic of Korea.; others
Keywords: SARS-CoV-2, spatial transcriptome atlas, lungs, immune response, primates
Summary of Study: Pulmonary microstructure-specific COVID-19 gene signatures
References: DOI: 10.1038/s42003-023-05253-8
Contact Info: Jung Joo Hong: hong75@kribb.re.kr
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462721/
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: KRIBB School of Bioscience, Korea University of Science & Technology (UST), Daejeon, Republic of Korea; National Primate Research Centre, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Chungcheongbuk, Republic of Korea.; others
Keywords: SARS-CoV-2, spatial transcriptome atlas, lungs, immune response, primates
Summary of Study: Pulmonary microstructure-specific COVID-19 gene signatures
References: DOI: 10.1038/s42003-023-05253-8
Contact Info: Jung Joo Hong: hong75@kribb.re.kr
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462721/
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: University of South Carolina; Tulane National Primate Research Center
Keywords: SARS-CoV-2, brain, pathology, in situ hybridization, primates
Summary of Study: SARS-CoV-2 RNA Persists in the Central Nervous System despite clinical recovery
References: DOI: 10.1101/2023.08.29.555368
Contact Info: Rosemarie Booze: booze@mailbox.sc.edu
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491216/
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: University of South Carolina; Tulane National Primate Research Center
Keywords: SARS-CoV-2, brain, pathology, in situ hybridization, primates
Summary of Study: SARS-CoV-2 RNA Persists in the Central Nervous System despite clinical recovery
References: DOI: 10.1101/2023.08.29.555368
Contact Info: Rosemarie Booze: booze@mailbox.sc.edu
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491216/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School, Boston, MA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA; numerous others
Keywords: SARS-CoV-2, immunogenicity and protective efficacy, subunit vaccine, virus strains, primates
Summary of Study: Immunogenicity and protective efficacy of GBP510/AS03 vaccine
References: doi: 10.1038/s41541-023-00622-0
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.nature.com/articles/s41541-023-00622-0
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School, Boston, MA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA; numerous others
Keywords: SARS-CoV-2, immunogenicity and protective efficacy, subunit vaccine, virus strains, primates
Summary of Study: Immunogenicity and protective efficacy of GBP510/AS03 vaccine
References: doi: 10.1038/s41541-023-00622-0
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.nature.com/articles/s41541-023-00622-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Massachusetts Consortium on Pathogen Readiness, Boston, MA USA and others
Keywords: SARS-CoV-2, omicron spike protein encoding vaccine, boosters, immune response, primates
Summary of Study: Booster with Ad26.COV2.S or Omicron-adapted vaccine enhanced immunity and efficacy
References: PMID: 37029141 / 10.1038/s41467-023-37715-2
Contact Info: Frank Wegmann: fwegmann@its.jnj.com
URL: https://www.nature.com/articles/s41467-023-37715-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Massachusetts Consortium on Pathogen Readiness, Boston, MA USA and others
Keywords: SARS-CoV-2, omicron spike protein encoding vaccine, boosters, immune response, primates
Summary of Study: Booster with Ad26.COV2.S or Omicron-adapted vaccine enhanced immunity and efficacy
References: PMID: 37029141 / 10.1038/s41467-023-37715-2
Contact Info: Frank Wegmann: fwegmann@its.jnj.com
URL: https://www.nature.com/articles/s41467-023-37715-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Sanofi, Vaccines R&D, Marcy l'Etoile, France, and others
Keywords: SARS-CoV-2, bivalent vaccine, virus variants, immune response, primates
Summary of Study: Beta-containing bivalent SARS-CoV-2 protein vaccine elicits durable broad neutralization
References: doi: 10.1038/s43856-023-00302-z
Contact Info: Valerie Lecouturier: valerie.lecouturier@sanofi.com
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212738/
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Sanofi, Vaccines R&D, Marcy l'Etoile, France, and others
Keywords: SARS-CoV-2, bivalent vaccine, virus variants, immune response, primates
Summary of Study: Beta-containing bivalent SARS-CoV-2 protein vaccine elicits durable broad neutralization
References: doi: 10.1038/s43856-023-00302-z
Contact Info: Valerie Lecouturier: valerie.lecouturier@sanofi.com
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212738/
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Faculty of Mathematics and Natural Sciences, University of Greifswald, Greifswald, Germany; Institute of Immunology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany; others
Keywords: SARS-CoV-2, review, tuberculosis, pathogenesis, several species, primates
Summary of Study: Animal models for COVID-19 and tuberculosis
References: DOI: 10.3389/fimmu.2023.1223260
Contact Info: Björn Corleis: bjoern.corleis@fli.de
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1223260/full
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Faculty of Mathematics and Natural Sciences, University of Greifswald, Greifswald, Germany; Institute of Immunology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany; others
Keywords: SARS-CoV-2, review, tuberculosis, pathogenesis, several species, primates
Summary of Study: Animal models for COVID-19 and tuberculosis
References: DOI: 10.3389/fimmu.2023.1223260
Contact Info: Björn Corleis: bjoern.corleis@fli.de
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1223260/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: West China Hospital Sichuan University Chengdu China; ichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu Sichuan China; others
Keywords: SARS-CoV-2, spheroid-embryonoid stem cells, viral variants, immune response, primates
Summary of Study: 3D-engineered multifunctional biologics to reverse immune system evasion
References: DOI: 10.1002/btm2.10554
Contact Info: Xiancheng Chen: chenwcrs@163.com
URL: https://aiche.onlinelibrary.wiley.com/doi/full/10.1002/btm2.10554
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: West China Hospital Sichuan University Chengdu China; ichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu Sichuan China; others
Keywords: SARS-CoV-2, spheroid-embryonoid stem cells, viral variants, immune response, primates
Summary of Study: 3D-engineered multifunctional biologics to reverse immune system evasion
References: DOI: 10.1002/btm2.10554
Contact Info: Xiancheng Chen: chenwcrs@163.com
URL: https://aiche.onlinelibrary.wiley.com/doi/full/10.1002/btm2.10554
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: University of Bremen, Bremen, Germany and others
Keywords: SARS-CoV-2, mRNA vaccination, elderly animals, immune response, primates
Summary of Study: Monitoring vaccination in laboratory rhesus monkeys
References: doi: 10.1038/s41598-023-30473-7
Contact Info: Detlef Wegener: dwegener@uni-bremen.de
URL: https://www.nature.com/articles/s41598-023-30473-7
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: University of Bremen, Bremen, Germany and others
Keywords: SARS-CoV-2, mRNA vaccination, elderly animals, immune response, primates
Summary of Study: Monitoring vaccination in laboratory rhesus monkeys
References: doi: 10.1038/s41598-023-30473-7
Contact Info: Detlef Wegener: dwegener@uni-bremen.de
URL: https://www.nature.com/articles/s41598-023-30473-7