Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai 200438, China; Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200438, China; Zhangjiang mRNA Innovation and Translation Center, Fudan University, Shanghai 200438, China; others
Keywords: SARS-CoV-2, mRNA vaccine, chimeric spike protein, immunogenicity, primates
Summary of Study: RQ3013, a broad-spectrum mRNA vaccine against variants
References: PMID: 37993332 DOI: 10.1016/j.scib.2023.11.024
Contact Info: Jinzhong Lin: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2095927323007788?via%3Dihub
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai 200438, China; Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200438, China; Zhangjiang mRNA Innovation and Translation Center, Fudan University, Shanghai 200438, China; others
Keywords: SARS-CoV-2, mRNA vaccine, chimeric spike protein, immunogenicity, primates
Summary of Study: RQ3013, a broad-spectrum mRNA vaccine against variants
References: PMID: 37993332 DOI: 10.1016/j.scib.2023.11.024
Contact Info: Jinzhong Lin: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2095927323007788?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: University of Maryland School of Medicine, Baltimore, MD, others
Keywords: SARS-CoV-2, recombinant vaccine, immune response, virus variants, mice, primates
Summary of Study: Recombinant prefusion-stabilized spike (rS) protein vaccine based on Beta/B.1.351 (rS-Beta) produces robust anamnestic response
References: doi: 10.1038/s41467-022-35606-6
Contact Info: Matthew Freiman: [email protected]
URL: https://www.nature.com/articles/s41467-022-35606-6
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: University of Maryland School of Medicine, Baltimore, MD, others
Keywords: SARS-CoV-2, recombinant vaccine, immune response, virus variants, mice, primates
Summary of Study: Recombinant prefusion-stabilized spike (rS) protein vaccine based on Beta/B.1.351 (rS-Beta) produces robust anamnestic response
References: doi: 10.1038/s41467-022-35606-6
Contact Info: Matthew Freiman: [email protected]
URL: https://www.nature.com/articles/s41467-022-35606-6
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School, Boston, MA, USA; Beth Israel Deaconess Medical Center, Boston, MA, USA, others
Keywords: SARS-CoV-2, immunogenicity and protective efficacy, Ad26.COV2.S vaccine, primates
Summary of Study: Spike protein ferritin nanoparticle vaccine
References: PMID: 37023746 / doi: 10.1016/j.xcrm.2023.101018
Contact Info: Dan Barouch: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379123001283?via%3Dihub
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School, Boston, MA, USA; Beth Israel Deaconess Medical Center, Boston, MA, USA, others
Keywords: SARS-CoV-2, immunogenicity and protective efficacy, Ad26.COV2.S vaccine, primates
Summary of Study: Spike protein ferritin nanoparticle vaccine
References: PMID: 37023746 / doi: 10.1016/j.xcrm.2023.101018
Contact Info: Dan Barouch: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379123001283?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine, Tulane National Primate Research Center, others
Keywords: SARS-CoV-2, CSF, neuropathology, proteomics, mass-spectrometry, primates
Summary of Study: Cerebrospinal Fluid Protein Markers Indicate Neuro-Damage in SARS-CoV-2-Infected Nonhuman Primates.
References: DOI: 10.1016/j.mcpro.2023.100523
Contact Info: Jia Fan: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981268/
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine, Tulane National Primate Research Center, others
Keywords: SARS-CoV-2, CSF, neuropathology, proteomics, mass-spectrometry, primates
Summary of Study: Cerebrospinal Fluid Protein Markers Indicate Neuro-Damage in SARS-CoV-2-Infected Nonhuman Primates.
References: DOI: 10.1016/j.mcpro.2023.100523
Contact Info: Jia Fan: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981268/
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Vaccine Research Institute, Créteil, France; Université Paris Cité, IAME, Inserm, Paris, France; others
Keywords: SARS-CoV-2, mathematical model, viral dynamic, primates
Summary of Study: Impact of variants of concern on SARS-CoV-2 viral dynamics
References: DOI: 10.1371/journal.pcbi.1010721
Contact Info: Aurélien Marc: [email protected]
URL: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1010721
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Vaccine Research Institute, Créteil, France; Université Paris Cité, IAME, Inserm, Paris, France; others
Keywords: SARS-CoV-2, mathematical model, viral dynamic, primates
Summary of Study: Impact of variants of concern on SARS-CoV-2 viral dynamics
References: DOI: 10.1371/journal.pcbi.1010721
Contact Info: Aurélien Marc: [email protected]
URL: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1010721
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: National Institutes of Health, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
Keywords: SARS-CoV-2, attenuated murine pneumonia virus vector, vaccine immune response, primates
Summary of Study: Mucosal prime-boost immunization with live murine pneumonia virus-vectored vaccine
References: DOI: 10.21203/rs.3.rs-3278289/v1
Contact Info: Ursula Buchholz: [email protected]
URL: https://www.researchsquare.com/article/rs-3278289/v1
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: National Institutes of Health, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
Keywords: SARS-CoV-2, attenuated murine pneumonia virus vector, vaccine immune response, primates
Summary of Study: Mucosal prime-boost immunization with live murine pneumonia virus-vectored vaccine
References: DOI: 10.21203/rs.3.rs-3278289/v1
Contact Info: Ursula Buchholz: [email protected]
URL: https://www.researchsquare.com/article/rs-3278289/v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Tulane National Primate Research Center, Covington, Louisiana; others
Keywords: SARS-CoV-2, SIV-Induced Immunodeficiency, immune response, coinfection, primates
Summary of Study: Impact of SIV-Induced Immunodeficiency on Clinical Manifestation, Immune Response, and Viral Dynamics in SARS-CoV-2 Coinfection
References: bioRxiv.2023 Nov 16:2023.11.15.567132. doi: 10.1101/2023.11.15.567132. Preprint. PMID: 38014096 PMCID: PMC10680717 DOI: 10.1101/2023.11.15.567132
Contact Info: Nicholas Maness: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.11.15.567132v1
NHP Species: pigtail macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Tulane National Primate Research Center, Covington, Louisiana; others
Keywords: SARS-CoV-2, SIV-Induced Immunodeficiency, immune response, coinfection, primates
Summary of Study: Impact of SIV-Induced Immunodeficiency on Clinical Manifestation, Immune Response, and Viral Dynamics in SARS-CoV-2 Coinfection
References: bioRxiv.2023 Nov 16:2023.11.15.567132. doi: 10.1101/2023.11.15.567132. Preprint. PMID: 38014096 PMCID: PMC10680717 DOI: 10.1101/2023.11.15.567132
Contact Info: Nicholas Maness: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.11.15.567132v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Beijing Engineering Research Center of Protein and Antibody, Sinocelltech Ltd., Beijing, China; Cell Culture Engineering Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Keywords: SARS-CoV-2, nanoparticle vaccine, immunogenicity, toxicity, primates
Summary of Study: COVID-19 vaccine showed high immunogenicity and low toxicity in animal models
References: doi: 10.3390/vaccines11030526
Contact Info: Liangzhi Xie: [email protected]
URL: https://www.mdpi.com/2076-393X/11/3/526
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Beijing Engineering Research Center of Protein and Antibody, Sinocelltech Ltd., Beijing, China; Cell Culture Engineering Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Keywords: SARS-CoV-2, nanoparticle vaccine, immunogenicity, toxicity, primates
Summary of Study: COVID-19 vaccine showed high immunogenicity and low toxicity in animal models
References: doi: 10.3390/vaccines11030526
Contact Info: Liangzhi Xie: [email protected]
URL: https://www.mdpi.com/2076-393X/11/3/526
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: University of Washington, Seattle, Washington USA; HDT Bio, Washington National Primate Research Center, others
Keywords: SARS-CoV-2, replicon RNA vaccine, immune response and protection, primates
Summary of Study: Replicon RNA vaccine for durable protective immunity
References: PMID: 37075079 / doi: 10.1371/journal.ppat.1011298
Contact Info: Jesse Erasmus: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011298
NHP Species: pigtail macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: University of Washington, Seattle, Washington USA; HDT Bio, Washington National Primate Research Center, others
Keywords: SARS-CoV-2, replicon RNA vaccine, immune response and protection, primates
Summary of Study: Replicon RNA vaccine for durable protective immunity
References: PMID: 37075079 / doi: 10.1371/journal.ppat.1011298
Contact Info: Jesse Erasmus: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011298
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, China; others
Keywords: SARS-CoV-2, inactivated vaccine, immune response, primates
Summary of Study: Preclinical safety evaluation of intradermal SARS-CoV-2 inactivated vaccine (Vero cells) administration in macaques.
References: DOI: 10.1016/j.vaccine.2023.03.033
Contact Info: Qihan Li: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003171?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, China; others
Keywords: SARS-CoV-2, inactivated vaccine, immune response, primates
Summary of Study: Preclinical safety evaluation of intradermal SARS-CoV-2 inactivated vaccine (Vero cells) administration in macaques.
References: DOI: 10.1016/j.vaccine.2023.03.033
Contact Info: Qihan Li: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003171?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Molecular Genetics, University of Toronto; Toronto, Canada; Icosagen Cell Factory OÜ; Tartu, Estonia; others
Keywords: SARS-CoV-2, humanized antibodies, immune response, vaccine, primates
Summary of Study: bnAb protection through inhalation-based delivery
References: DOI: 10.1371/journal.ppat.1011532
Contact Info: Mart Ustav, Jr.: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011532
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Molecular Genetics, University of Toronto; Toronto, Canada; Icosagen Cell Factory OÜ; Tartu, Estonia; others
Keywords: SARS-CoV-2, humanized antibodies, immune response, vaccine, primates
Summary of Study: bnAb protection through inhalation-based delivery
References: DOI: 10.1371/journal.ppat.1011532
Contact Info: Mart Ustav, Jr.: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011532
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Center for Genetic Engineering and Biotechnology, Production Division, Havana, Cuba
Keywords: SARS-CoV-2, chimeric antigen, vaccine, immune response, mice, primates
Summary of Study: chimeric antigen, based on nucleocapsid of SARS-CoV-2 fused to the extracellular domain of human CD154 in HEK-293 cells
References: DOI: 10.1371/journal.pone.0288006
Contact Info: Mario Pablo Estrada: [email protected]; Yamila Carpio: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0288006
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Center for Genetic Engineering and Biotechnology, Production Division, Havana, Cuba
Keywords: SARS-CoV-2, chimeric antigen, vaccine, immune response, mice, primates
Summary of Study: chimeric antigen, based on nucleocapsid of SARS-CoV-2 fused to the extracellular domain of human CD154 in HEK-293 cells
References: DOI: 10.1371/journal.pone.0288006
Contact Info: Mario Pablo Estrada: [email protected]; Yamila Carpio: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0288006
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Gwanak-gu, Seoul, 08826, Republic of Korea; others
Keywords: SARS-CoV-2, pulmonary lesions, histopathology, primates
Summary of Study: Histopathological pulmonary lesions in SARS-CoV-2
References: PMID: 38007889 DOI: 10.1016/j.jcpa.2023.10.008
Contact Info: Jae-Hak Park: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0021997523002967?via%3Dihub
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Gwanak-gu, Seoul, 08826, Republic of Korea; others
Keywords: SARS-CoV-2, pulmonary lesions, histopathology, primates
Summary of Study: Histopathological pulmonary lesions in SARS-CoV-2
References: PMID: 38007889 DOI: 10.1016/j.jcpa.2023.10.008
Contact Info: Jae-Hak Park: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0021997523002967?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Duke University School of Medicine, Durham, NC; others
Keywords: SARS-CoV-2, spike protein, mRNA vaccine, immune response, virus variants, conserved epitopes, primates
Summary of Study: Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination
References: bioRxiv PMID: 38187726 PMCID: PMC10769253 DOI: 10.1101/2023.12.18.572191
Contact Info: Kevin O. Saunders: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.12.18.572191v1
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Duke University School of Medicine, Durham, NC; others
Keywords: SARS-CoV-2, spike protein, mRNA vaccine, immune response, virus variants, conserved epitopes, primates
Summary of Study: Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination
References: bioRxiv PMID: 38187726 PMCID: PMC10769253 DOI: 10.1101/2023.12.18.572191
Contact Info: Kevin O. Saunders: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.12.18.572191v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland; Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Mary
Keywords: SARS-CoV-2, deep learning, computerized tomography, lung lesions, primates
Summary of Study: Modeling whole lung and lung lesions to detect and quantify disease
References: doi: 10.1016/j.acra.2023.02.027
Contact Info: [email protected]
URL: https://pubmed.ncbi.nlm.nih.gov/36966070/
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland; Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Mary
Keywords: SARS-CoV-2, deep learning, computerized tomography, lung lesions, primates
Summary of Study: Modeling whole lung and lung lesions to detect and quantify disease
References: doi: 10.1016/j.acra.2023.02.027
Contact Info: [email protected]
URL: https://pubmed.ncbi.nlm.nih.gov/36966070/
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Federal Medical-Biological Agency of Russia, Moscow, Russia and others
Keywords: SARS-CoV-2, nucleocapsid (N) protein, vaccine, immune response, pathology, mice, hamsters, primates
Summary of Study: Recombinant nucleocapsid-based vaccine Convacell®.
References: PMID: 37112786 / doi: 10.3390/vaccines11040874
Contact Info: Sevastyan Rabdano: [email protected]
URL: https://www.mdpi.com/2076-393X/11/4/874
NHP Species: marmosets
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Federal Medical-Biological Agency of Russia, Moscow, Russia and others
Keywords: SARS-CoV-2, nucleocapsid (N) protein, vaccine, immune response, pathology, mice, hamsters, primates
Summary of Study: Recombinant nucleocapsid-based vaccine Convacell®.
References: PMID: 37112786 / doi: 10.3390/vaccines11040874
Contact Info: Sevastyan Rabdano: [email protected]
URL: https://www.mdpi.com/2076-393X/11/4/874
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea; others
Keywords: SARS-CoV-2, spatial transcriptomic profiling, lungs, virus variants, primates
Summary of Study: Comparative spatial transcriptomic profiling of severe acute respiratory syndrome coronavirus 2 Delta and Omicron variants infections in the lungs of cynomolgus macaques.
References: DOI: 10.1002/jmv.28847
Contact Info: Jung Joo Hong: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/jmv.28847
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea; others
Keywords: SARS-CoV-2, spatial transcriptomic profiling, lungs, virus variants, primates
Summary of Study: Comparative spatial transcriptomic profiling of severe acute respiratory syndrome coronavirus 2 Delta and Omicron variants infections in the lungs of cynomolgus macaques.
References: DOI: 10.1002/jmv.28847
Contact Info: Jung Joo Hong: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/jmv.28847
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Neurobiology and Aging, Biomedical Primate Research Centre (BPRC), Lange Kleiweg 161, 2288GJ, Rijswijk, The Netherlands; others
Keywords: SARS-CoV-2, neuroinflammation, positron emission tomography, brain, primates
Summary of Study: Widespread neuroinflammation in SARS-CoV-2 infection
References: DOI: 10.1186/s12974-023-02857-z
Contact Info: Jinte Middeldorp: [email protected]
URL: https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-023-02857-z
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Neurobiology and Aging, Biomedical Primate Research Centre (BPRC), Lange Kleiweg 161, 2288GJ, Rijswijk, The Netherlands; others
Keywords: SARS-CoV-2, neuroinflammation, positron emission tomography, brain, primates
Summary of Study: Widespread neuroinflammation in SARS-CoV-2 infection
References: DOI: 10.1186/s12974-023-02857-z
Contact Info: Jinte Middeldorp: [email protected]
URL: https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-023-02857-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: University of Kentucky, University of California Irvine, USA
Keywords: SARS-CoV-2, alcohol, lung, scRNA sequencing, flow cytometry, primates
Summary of Study: Chronic alcohol consumption dysregulates innate immune response to SARS-CoV-2 in the lung
References: DOI: 10.1016/j.ebiom.2023.104812
Contact Info: Ilhem Messaoudi: ilhem@[email protected]
URL: https://www.sciencedirect.com/science/article/pii/S235239642300378X?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: University of Kentucky, University of California Irvine, USA
Keywords: SARS-CoV-2, alcohol, lung, scRNA sequencing, flow cytometry, primates
Summary of Study: Chronic alcohol consumption dysregulates innate immune response to SARS-CoV-2 in the lung
References: DOI: 10.1016/j.ebiom.2023.104812
Contact Info: Ilhem Messaoudi: ilhem@[email protected]
URL: https://www.sciencedirect.com/science/article/pii/S235239642300378X?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; others
Keywords: SARS-CoV-2, Beta-spike-containing boosters, immune response, primates
Summary of Study: Beta-spike-containing boosters induce robust and functional antibody responses
References: PMID: 38007686 DOI: 10.1016/j.celrep.2023.113292
Contact Info: Ryan McNamara: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2211124723013049?via%3Dihub
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; others
Keywords: SARS-CoV-2, Beta-spike-containing boosters, immune response, primates
Summary of Study: Beta-spike-containing boosters induce robust and functional antibody responses
References: PMID: 38007686 DOI: 10.1016/j.celrep.2023.113292
Contact Info: Ryan McNamara: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2211124723013049?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Vaxxinity, Inc., Merritt Island, FL, USA; University of Texas Medical Branch, Galveston, TX, USA; others
Keywords: SARS-CoV-2, subunit vaccine, Fc-mediated effector function, immune response, primates
Summary of Study: RBD-Protein/Peptide Vaccine UB-612 Elicits Mucosal and Fc-Mediated Antibody Responses
References: PMID: 38250853 PMCID: PMC10818657 DOI: 10.3390/vaccines12010040
Contact Info: Shixia Wang: [email protected]
URL: https://www.mdpi.com/2076-393X/12/1/40
NHP Species: cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Vaxxinity, Inc., Merritt Island, FL, USA; University of Texas Medical Branch, Galveston, TX, USA; others
Keywords: SARS-CoV-2, subunit vaccine, Fc-mediated effector function, immune response, primates
Summary of Study: RBD-Protein/Peptide Vaccine UB-612 Elicits Mucosal and Fc-Mediated Antibody Responses
References: PMID: 38250853 PMCID: PMC10818657 DOI: 10.3390/vaccines12010040
Contact Info: Shixia Wang: [email protected]
URL: https://www.mdpi.com/2076-393X/12/1/40
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Biosystems, Laboratory of Gene Technology, KU Leuven, Leuven Belgium
Keywords: SARS-CoV-2, review, vaccine development, mice, hamsters, primates
Summary of Study: Do we need nasal vaccines against COVID 19
References: doi: 10.1111/1751-7915.14181
Contact Info: Harald Brüssow: [email protected]
URL: https://ami-journals.onlinelibrary.wiley.com/doi/full/10.1111/1751-7915.14181
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Biosystems, Laboratory of Gene Technology, KU Leuven, Leuven Belgium
Keywords: SARS-CoV-2, review, vaccine development, mice, hamsters, primates
Summary of Study: Do we need nasal vaccines against COVID 19
References: doi: 10.1111/1751-7915.14181
Contact Info: Harald Brüssow: [email protected]
URL: https://ami-journals.onlinelibrary.wiley.com/doi/full/10.1111/1751-7915.14181
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Veterinary Research Institute, Lahore, Pakistan; Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan; others
Keywords: SARS-CoV-2, inactivated vaccine, efficacy, immunogenicity, virus variant, rabbits, primates
Summary of Study: Molecular characterization and selection of delta variant for vaccine
References: doi: 10.3390/vaccines11030607
Contact Info: Tahir Yaqub: [email protected]
URL: https://www.mdpi.com/2076-393X/11/3/607
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Veterinary Research Institute, Lahore, Pakistan; Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan; others
Keywords: SARS-CoV-2, inactivated vaccine, efficacy, immunogenicity, virus variant, rabbits, primates
Summary of Study: Molecular characterization and selection of delta variant for vaccine
References: doi: 10.3390/vaccines11030607
Contact Info: Tahir Yaqub: [email protected]
URL: https://www.mdpi.com/2076-393X/11/3/607
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Chulalongkorn University, Bangkok, Thailand and others
Keywords: SARS-CoV-2, recombinant plant-based RBD vaccine, immunogenicity, efficacy, safety, mice, primates
Summary of Study: Recombinant plant based RBD vaccine formulated with 3M-052-Alum adjuvant
References: PMID: 36963999 / doi: 10.1016/j.vaccine.2023.03.027
Contact Info: Waranyoo Phoolcharoen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003122?via%3Dihub
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Chulalongkorn University, Bangkok, Thailand and others
Keywords: SARS-CoV-2, recombinant plant-based RBD vaccine, immunogenicity, efficacy, safety, mice, primates
Summary of Study: Recombinant plant based RBD vaccine formulated with 3M-052-Alum adjuvant
References: PMID: 36963999 / doi: 10.1016/j.vaccine.2023.03.027
Contact Info: Waranyoo Phoolcharoen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003122?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China; others
Keywords: SARS-CoV-2, pathogenesis, immune response, mice, hamsters, primates
Summary of Study: SARS-CoV-2 Omicron (B.1.1.529) infection in rhesus macaques, hamsters, and BALB/c mice with severe lung histopathological damage.
References: DOI: 10.1002/jmv.28846
Contact Info: Shuaiyao Lu: [email protected]
URL: https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.28846
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China; others
Keywords: SARS-CoV-2, pathogenesis, immune response, mice, hamsters, primates
Summary of Study: SARS-CoV-2 Omicron (B.1.1.529) infection in rhesus macaques, hamsters, and BALB/c mice with severe lung histopathological damage.
References: DOI: 10.1002/jmv.28846
Contact Info: Shuaiyao Lu: [email protected]
URL: https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.28846
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Emory University School of Medicine; Emory, Oregon and Tulane NPRCs; numerous others
Keywords: SARS-CoV-2, IFN-I, immune response, pathology, primates
Summary of Study: Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation
References: DOI: 10.1126/sciimmunol.adg0033
Contact Info: Mirko Paiardini: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.adg0033
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Emory University School of Medicine; Emory, Oregon and Tulane NPRCs; numerous others
Keywords: SARS-CoV-2, IFN-I, immune response, pathology, primates
Summary of Study: Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation
References: DOI: 10.1126/sciimmunol.adg0033
Contact Info: Mirko Paiardini: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.adg0033
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Research Institute of Cardiology and Internal Medicine, Almaty, KazakhstanInternational Center for Vaccinology, Kazakh National Agrarian Research University (KazNARU), Almaty, Kazakhstan; others
Keywords: SARS-CoV-2, vaccine, adjuvant, immune response, safety, hamsters, primates
Summary of Study: Evaluation of spike protein ectodomain subunit vaccine with squalene emulsion adjuvant
References: DOI: 10.1080/21645515.2023.2258571
Contact Info: Kairat Tabynov: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/21645515.2023.2258571
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Research Institute of Cardiology and Internal Medicine, Almaty, KazakhstanInternational Center for Vaccinology, Kazakh National Agrarian Research University (KazNARU), Almaty, Kazakhstan; others
Keywords: SARS-CoV-2, vaccine, adjuvant, immune response, safety, hamsters, primates
Summary of Study: Evaluation of spike protein ectodomain subunit vaccine with squalene emulsion adjuvant
References: DOI: 10.1080/21645515.2023.2258571
Contact Info: Kairat Tabynov: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/21645515.2023.2258571
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: State Key Laboratory of Medical Molecular Biology Department of Molecular Biology and Biochemistry Institute of Basic Medical Sciences Medical Primate Research Center Neuroscience Center Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical College Beijing China; others
Keywords: SARS-CoV-2, immune response, PBMCs, single?cell sequencing, virus variants, primates
Summary of Study: Single-cell transcriptomic atlas of distinct early immune responses
References: PMID: 38020713 PMCID: PMC10661830 DOI: 10.1002/mco2.432
Contact Info: Xiaozhong Peng: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661830/
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: State Key Laboratory of Medical Molecular Biology Department of Molecular Biology and Biochemistry Institute of Basic Medical Sciences Medical Primate Research Center Neuroscience Center Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical College Beijing China; others
Keywords: SARS-CoV-2, immune response, PBMCs, single?cell sequencing, virus variants, primates
Summary of Study: Single-cell transcriptomic atlas of distinct early immune responses
References: PMID: 38020713 PMCID: PMC10661830 DOI: 10.1002/mco2.432
Contact Info: Xiaozhong Peng: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661830/
Coronavirus Investigated: SARS-CoV-2
NHP Species: lemurs
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Universidad Cardenal Herrera-CEU, 46113 Valencia, Spain; others
Keywords: SARS-CoV-2, natural infection, serological testing, RNA analysis, primates
Summary of Study: Molecular and serological studies on potential SARS-CoV-2 Infection
References: PMID: 38200871 PMCID: PMC10778278 DOI: 10.3390/ani14010140
Contact Info: Consuelo Rubio-Guerri: [email protected]
URL: https://www.mdpi.com/2076-2615/14/1/140
NHP Species: lemurs
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Universidad Cardenal Herrera-CEU, 46113 Valencia, Spain; others
Keywords: SARS-CoV-2, natural infection, serological testing, RNA analysis, primates
Summary of Study: Molecular and serological studies on potential SARS-CoV-2 Infection
References: PMID: 38200871 PMCID: PMC10778278 DOI: 10.3390/ani14010140
Contact Info: Consuelo Rubio-Guerri: [email protected]
URL: https://www.mdpi.com/2076-2615/14/1/140
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX; Office of Regulated Nonclinical Studies, University of Texas Medical Branch, Galveston, TX; others
Keywords: SARS-CoV-2, Molnupiravir, efficacy, oral administration, primates
Summary of Study: Evaluation of the drug molnupiravir (EIDD-2801) for mild to moderate COVID-19
References: doi: 10.1016/j.antiviral.2022.105492
Contact Info: Jason Comer: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0166354222002613?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX; Office of Regulated Nonclinical Studies, University of Texas Medical Branch, Galveston, TX; others
Keywords: SARS-CoV-2, Molnupiravir, efficacy, oral administration, primates
Summary of Study: Evaluation of the drug molnupiravir (EIDD-2801) for mild to moderate COVID-19
References: doi: 10.1016/j.antiviral.2022.105492
Contact Info: Jason Comer: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0166354222002613?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Sanofi and GSK
Keywords: SARS-CoV-2, booster vaccine candidates, immune response, virus variants, primates
Summary of Study: Beta variant COVID-19 protein booster vaccine elicits durable cross-neutralization against SARS-CoV-2 variants
References: doi: 10.1038/s41467-023-36908-z
Contact Info: Valerie Lecouturier: [email protected]
URL: https://www.nature.com/articles/s41467-023-36908-z
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Sanofi and GSK
Keywords: SARS-CoV-2, booster vaccine candidates, immune response, virus variants, primates
Summary of Study: Beta variant COVID-19 protein booster vaccine elicits durable cross-neutralization against SARS-CoV-2 variants
References: doi: 10.1038/s41467-023-36908-z
Contact Info: Valerie Lecouturier: [email protected]
URL: https://www.nature.com/articles/s41467-023-36908-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, China and others
Keywords: SARS-CoV-2, intradermal inactivated vaccine, immune response, virus variants, primates
Summary of Study: Preclinical safety evaluation of Intradermal inactivated vaccine (vero cells) administration
References: PMID: 37003910 / doi: 10.1016/j.vaccine.2023.03.033
Contact Info: Qihan Li: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003171?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, China and others
Keywords: SARS-CoV-2, intradermal inactivated vaccine, immune response, virus variants, primates
Summary of Study: Preclinical safety evaluation of Intradermal inactivated vaccine (vero cells) administration
References: PMID: 37003910 / doi: 10.1016/j.vaccine.2023.03.033
Contact Info: Qihan Li: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003171?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China; others
Keywords: SARS-CoV-2, pathogenesis, immune response, mice, hamsters, primates
Summary of Study: SARS-CoV-2 Omicron (B.1.1.529) infection in rhesus macaques, hamsters, and BALB/c mice with severe lung histopathological damage.
References: DOI: 10.1002/jmv.28846
Contact Info: Shuaiyao Lu: [email protected]
URL: https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.28846
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China; others
Keywords: SARS-CoV-2, pathogenesis, immune response, mice, hamsters, primates
Summary of Study: SARS-CoV-2 Omicron (B.1.1.529) infection in rhesus macaques, hamsters, and BALB/c mice with severe lung histopathological damage.
References: DOI: 10.1002/jmv.28846
Contact Info: Shuaiyao Lu: [email protected]
URL: https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.28846
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Spain; others
Keywords: SARS-CoV-2, PHH-1V, vaccine, immune response, airways, primates
Summary of Study: Preclinical evaluation of PHH-1V vaccine candidate
References: DOI: 10.1016/j.isci.2023.107224
Contact Info: Antoni Prenafeta: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2589004223013019?via%3Dihub
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Spain; others
Keywords: SARS-CoV-2, PHH-1V, vaccine, immune response, airways, primates
Summary of Study: Preclinical evaluation of PHH-1V vaccine candidate
References: DOI: 10.1016/j.isci.2023.107224
Contact Info: Antoni Prenafeta: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2589004223013019?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Dhirubhai Ambani Life Sciences Centre, Reliance Life Sciences Pvt. Ltd., Rabale, Navi Mubai, India
Keywords: SARS-CoV-2, vaccine, dual receptor binding domain, immune response, safety, several species, primates
Summary of Study: Safety, immunogenicity and efficacy of Relcovax®
References: DOI: 10.1016/j.vaccine.2023.10.006
Contact Info: R.L. Ramnath: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23011763?via%3Dihub
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Dhirubhai Ambani Life Sciences Centre, Reliance Life Sciences Pvt. Ltd., Rabale, Navi Mubai, India
Keywords: SARS-CoV-2, vaccine, dual receptor binding domain, immune response, safety, several species, primates
Summary of Study: Safety, immunogenicity and efficacy of Relcovax®
References: DOI: 10.1016/j.vaccine.2023.10.006
Contact Info: R.L. Ramnath: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23011763?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: University of Alabama at Birmingham, University of Florida
Keywords: SARS-CoV-2, sexual dimorphism, transcriptomics, translation, immunogenicity, primates
Summary of Study: Sex differences in brain and susceptibility to COVID-19
References: PMID: 38045237 PMCID: PMC10690328 DOI: 10.21203/rs.3.rs-3422091/v1
Contact Info: Coy Heldermon: [email protected]
URL: https://www.researchsquare.com/article/rs-3422091/v1
NHP Species: cynomolgus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: University of Alabama at Birmingham, University of Florida
Keywords: SARS-CoV-2, sexual dimorphism, transcriptomics, translation, immunogenicity, primates
Summary of Study: Sex differences in brain and susceptibility to COVID-19
References: PMID: 38045237 PMCID: PMC10690328 DOI: 10.21203/rs.3.rs-3422091/v1
Contact Info: Coy Heldermon: [email protected]
URL: https://www.researchsquare.com/article/rs-3422091/v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland; Adimab LLC, Lebanon, New Hampshire; Invivyd, Inc., Waltham, Massachusetts; others
Keywords: SARS-CoV-2, Adintrevimab, prophylactics, viral load, pathology, hamsters, primates
Summary of Study: Monoclonal Antibody Adintrevimab Protects against COVID-19
References: doi: 10.1128/aac.01353-22
Contact Info: Kristin Narayan: [email protected]
URL: https://journals.asm.org/doi/10.1128/aac.01353-22
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland; Adimab LLC, Lebanon, New Hampshire; Invivyd, Inc., Waltham, Massachusetts; others
Keywords: SARS-CoV-2, Adintrevimab, prophylactics, viral load, pathology, hamsters, primates
Summary of Study: Monoclonal Antibody Adintrevimab Protects against COVID-19
References: doi: 10.1128/aac.01353-22
Contact Info: Kristin Narayan: [email protected]
URL: https://journals.asm.org/doi/10.1128/aac.01353-22
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Microbiology, Shanghai Municipal Center for Disease Control and Prevention, Shanghai , China; Key Laboratory of Medical Molecular Virology, Shanghai Institute of Infectious Disease and Biosecurity, others.
Keywords: SARS-CoV-2, pan-sarbecovirus vaccine, immune response, virus protection, primates
Summary of Study: Pan-sarbecovirus vaccines against sarbecoviruses, including SARS-CoV-2 and its variants
References: doi: 10.1073/pnas.2221713120
Contact Info: LuLu: [email protected] (and other authors
URL: https://www.pnas.org/doi/10.1073/pnas.2221713120
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Microbiology, Shanghai Municipal Center for Disease Control and Prevention, Shanghai , China; Key Laboratory of Medical Molecular Virology, Shanghai Institute of Infectious Disease and Biosecurity, others.
Keywords: SARS-CoV-2, pan-sarbecovirus vaccine, immune response, virus protection, primates
Summary of Study: Pan-sarbecovirus vaccines against sarbecoviruses, including SARS-CoV-2 and its variants
References: doi: 10.1073/pnas.2221713120
Contact Info: LuLu: [email protected] (and other authors
URL: https://www.pnas.org/doi/10.1073/pnas.2221713120
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: School of Pharmacy, University of Chinese Academy of Sciences, Beijing, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China, others
Keywords: SARS-CoV-2, nelfinavir, prophylactics, virus protection, humans, primates
Summary of Study: Nelfinavir preventive and therapeutic effects
References: PMID: 37095086 / doi: 10.1038/s41392-023-01429-0
Contact Info: Weiliang Zhu: [email protected]
URL: https://www.nature.com/articles/s41392-023-01429-0
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: School of Pharmacy, University of Chinese Academy of Sciences, Beijing, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China, others
Keywords: SARS-CoV-2, nelfinavir, prophylactics, virus protection, humans, primates
Summary of Study: Nelfinavir preventive and therapeutic effects
References: PMID: 37095086 / doi: 10.1038/s41392-023-01429-0
Contact Info: Weiliang Zhu: [email protected]
URL: https://www.nature.com/articles/s41392-023-01429-0
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Institut Pasteur, Université Paris Cité, National Reference Center for Respiratory Viruses, Paris, France; others
Keywords: SARS-CoV-2, monoclonal antibody treatment, immune response, primates
Summary of Study: Sotrovimab retains activity against SARS-CoV-2 omicron variant BQ.1.1 in a non-human primate model.
References: DOI: 10.1016/j.heliyon.2023.e16664
Contact Info: Roger Le Grand: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2405844023038719?via%3Dihub
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Institut Pasteur, Université Paris Cité, National Reference Center for Respiratory Viruses, Paris, France; others
Keywords: SARS-CoV-2, monoclonal antibody treatment, immune response, primates
Summary of Study: Sotrovimab retains activity against SARS-CoV-2 omicron variant BQ.1.1 in a non-human primate model.
References: DOI: 10.1016/j.heliyon.2023.e16664
Contact Info: Roger Le Grand: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2405844023038719?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China; others
Keywords: SARS-CoV-2, transcriptome analysis, virus variants, subgenomic RNA, primates
Summary of Study: Differential Transcriptomic Landscapes of SARS-CoV-2 Variants in Multiple Organs
References: doi:10.1016/j.gpb.2023.06.002
Contact Info: Xiaozhong Peng: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1672022923000955?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China; others
Keywords: SARS-CoV-2, transcriptome analysis, virus variants, subgenomic RNA, primates
Summary of Study: Differential Transcriptomic Landscapes of SARS-CoV-2 Variants in Multiple Organs
References: doi:10.1016/j.gpb.2023.06.002
Contact Info: Xiaozhong Peng: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1672022923000955?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France
Keywords: SARS-CoV-2, intestinal mucosal barrier, inflammation, pathology, primates
Summary of Study: Intestinal immunological events of acute and resolved infection
References: DOI: 10.1016/j.mucimm.2023.10.001
Contact Info: Mariangela Cavarelli: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S193302192300079X?via%3Dihub
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France
Keywords: SARS-CoV-2, intestinal mucosal barrier, inflammation, pathology, primates
Summary of Study: Intestinal immunological events of acute and resolved infection
References: DOI: 10.1016/j.mucimm.2023.10.001
Contact Info: Mariangela Cavarelli: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S193302192300079X?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: NIAID, Boston University, many others
Keywords: SARS-CoV-2, gorilla adenovirus (GRAd) S-2P vaccine, airways, immunogenicity, primates
Summary of Study: Airway immunity achieved with GRAd) S-2P vaccine in nhps
References: bioRxiv. 2023 Nov 22:2023.11.22.567930. doi: 10.1101/2023.11.22.567930. Preprint
Contact Info: Nancy Sullivan: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.11.22.567930v1
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: NIAID, Boston University, many others
Keywords: SARS-CoV-2, gorilla adenovirus (GRAd) S-2P vaccine, airways, immunogenicity, primates
Summary of Study: Airway immunity achieved with GRAd) S-2P vaccine in nhps
References: bioRxiv. 2023 Nov 22:2023.11.22.567930. doi: 10.1101/2023.11.22.567930. Preprint
Contact Info: Nancy Sullivan: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.11.22.567930v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, PA; others
Keywords: SARS-CoV-2, tetravalent S1 subunit protein vaccine, immune response, virus variants, primates
Summary of Study: Tetravalent S1 subunit protein vaccination elicits robust humoral and cellular immune responses
References: doi: 10.1101/2023.03.15.532808. Preprint
Contact Info: Christian Apetrei: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.03.15.532808v1
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, PA; others
Keywords: SARS-CoV-2, tetravalent S1 subunit protein vaccine, immune response, virus variants, primates
Summary of Study: Tetravalent S1 subunit protein vaccination elicits robust humoral and cellular immune responses
References: doi: 10.1101/2023.03.15.532808. Preprint
Contact Info: Christian Apetrei: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.03.15.532808v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Patronus Biotech Co. Ltd., Yantai, China
Keywords: SARS-CoV-2, RBD virus-like particle vaccine, immune response, virus infection, mice, primates
Summary of Study: RBD virus-like particle vaccine induces cross-variant antibody responses
References: PMID: 37120453 / doi: 10.1038/s41392-023-01425-4
Contact Info: Yuanyuan Li: [email protected]
URL: https://www.nature.com/articles/s41392-023-01425-4
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Patronus Biotech Co. Ltd., Yantai, China
Keywords: SARS-CoV-2, RBD virus-like particle vaccine, immune response, virus infection, mice, primates
Summary of Study: RBD virus-like particle vaccine induces cross-variant antibody responses
References: PMID: 37120453 / doi: 10.1038/s41392-023-01425-4
Contact Info: Yuanyuan Li: [email protected]
URL: https://www.nature.com/articles/s41392-023-01425-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Pathology, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liege, Liège, Belgium; others
Keywords: SARS-CoV-2, macrophages, single-cell RNA-seq analysis, immune response, hamsters, primates
Summary of Study: Central role of lung macrophages in SARS-CoV-2 physiopathology: a cross-model single-cell RNA-seq perspective.
References: DOI: 10.3389/fimmu.2023.1197588
Contact Info: Thibaut Olivier: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1197588/full
NHP Species: african green monkeys
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Pathology, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liege, Liège, Belgium; others
Keywords: SARS-CoV-2, macrophages, single-cell RNA-seq analysis, immune response, hamsters, primates
Summary of Study: Central role of lung macrophages in SARS-CoV-2 physiopathology: a cross-model single-cell RNA-seq perspective.
References: DOI: 10.3389/fimmu.2023.1197588
Contact Info: Thibaut Olivier: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1197588/full
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Universitas Airlangga, Surabaya, Indonesia
Keywords: SARS-CoV-2, inactivated vaccine, immune response, primates
Summary of Study: Inactivated SARS-CoV-2 vaccine candidate immunization
References: DOI: 10.1016/j.heliyon.2023.e18039
Contact Info: Fedik Abdul Rantam: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2405844023052477?via%3Dihub
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Universitas Airlangga, Surabaya, Indonesia
Keywords: SARS-CoV-2, inactivated vaccine, immune response, primates
Summary of Study: Inactivated SARS-CoV-2 vaccine candidate immunization
References: DOI: 10.1016/j.heliyon.2023.e18039
Contact Info: Fedik Abdul Rantam: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2405844023052477?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA; University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania, USA; others
Keywords: SARS-CoV-2, tetravalent vaccine, adjuvant, immune response, primates
Summary of Study: Tetravalent SARS-CoV-2 S1 subunit protein vaccination
References: DOI: 10.1128/mbio.02070-23
Contact Info: Andrea Gambotto: [email protected]
URL: https://journals.asm.org/doi/full/10.1128/mbio.02070-23?rfr_dat=cr_pub++0pubmed…
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA; University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania, USA; others
Keywords: SARS-CoV-2, tetravalent vaccine, adjuvant, immune response, primates
Summary of Study: Tetravalent SARS-CoV-2 S1 subunit protein vaccination
References: DOI: 10.1128/mbio.02070-23
Contact Info: Andrea Gambotto: [email protected]
URL: https://journals.asm.org/doi/full/10.1128/mbio.02070-23?rfr_dat=cr_pub++0pubmed…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Research Institute for Biological Safety Problems, The Ministry of Health of the Republic of Kazakhstan
Keywords: SARS-CoV-2, subunit vaccine; antigens; toxicity; safety; immunizing dose; immunogenicity, primates
Summary of Study: Coronavirus protein-based subunit vaccine safety and immunogenicity
References: PMID: 38140175 PMCID: PMC10748237 DOI: 10.3390/vaccines11121771
Contact Info: Ainur Nurpeisova: [email protected]
URL: https://www.mdpi.com/2076-393X/11/12/1771
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Research Institute for Biological Safety Problems, The Ministry of Health of the Republic of Kazakhstan
Keywords: SARS-CoV-2, subunit vaccine; antigens; toxicity; safety; immunizing dose; immunogenicity, primates
Summary of Study: Coronavirus protein-based subunit vaccine safety and immunogenicity
References: PMID: 38140175 PMCID: PMC10748237 DOI: 10.3390/vaccines11121771
Contact Info: Ainur Nurpeisova: [email protected]
URL: https://www.mdpi.com/2076-393X/11/12/1771
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Texas Biomedical Research Institute, Institute of Science and Technology on Biomodels, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
Keywords: SARS-CoV-2, review, coinfections, primate models, housing, screening
Summary of Study: Eliminating Potential Effects of Other Infections During Selection of Nonhuman Primates for COVID-19 Research
References: doi: 10.30802/AALAS-CM-21-000086
Contact Info: Marcia Andrade: [email protected]
URL: https://aalas.kglmeridian.com/view/journals/72010023/73/1/article-p91.xml
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Texas Biomedical Research Institute, Institute of Science and Technology on Biomodels, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
Keywords: SARS-CoV-2, review, coinfections, primate models, housing, screening
Summary of Study: Eliminating Potential Effects of Other Infections During Selection of Nonhuman Primates for COVID-19 Research
References: doi: 10.30802/AALAS-CM-21-000086
Contact Info: Marcia Andrade: [email protected]
URL: https://aalas.kglmeridian.com/view/journals/72010023/73/1/article-p91.xml