Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Harvard Medical School; Walter Reed National Military Medical Center; Ragon Institute of MGH, MIT and Harvard; Bioqual; University of Pittsburgh; Henry Jackson Foundation
Keywords: SARS-CoV-2, live oral vaccine, immune response, pathology, primates
Summary of Study: Post-pyloric inoculation of live SARS-CoV-2 is weakly immunogenic and confers partial protection against respiratory SARS-CoV-2 challenge in rhesus macaques.
References: doi: 10.1101/2021.09.13.460191
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.biorxiv.org/content/10.1101/2021.09.13.460191v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Harvard Medical School; Walter Reed National Military Medical Center; Ragon Institute of MGH, MIT and Harvard; Bioqual; University of Pittsburgh; Henry Jackson Foundation
Keywords: SARS-CoV-2, live oral vaccine, immune response, pathology, primates
Summary of Study: Post-pyloric inoculation of live SARS-CoV-2 is weakly immunogenic and confers partial protection against respiratory SARS-CoV-2 challenge in rhesus macaques.
References: doi: 10.1101/2021.09.13.460191
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.biorxiv.org/content/10.1101/2021.09.13.460191v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Yerkes National Primate Research Center, Emory University; Emory University School of Medicine; University of Pittsburgh
Keywords: SARS-CoV-2, multi-omic analyses, inflammation, immune response, primates
Summary of Study: Multi-omic analyses of hyperacute SARS-CoV-2 infection in rhesus macaques identified two populations of infiltrating macrophages as the primary orchestrators of inflammation in th elowre airway that can be successfully treated with baricitinib.
References: PMID: 34642693 / doi: 10.1101/2021.10.05.463212
Contact Info: Steven Bosinger: steven.bosinger@emory.edu; Mirko Paiardini: mirko.paiardini@emory.edu
URL: https://www.biorxiv.org/content/10.1101/2021.10.05.463212v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Yerkes National Primate Research Center, Emory University; Emory University School of Medicine; University of Pittsburgh
Keywords: SARS-CoV-2, multi-omic analyses, inflammation, immune response, primates
Summary of Study: Multi-omic analyses of hyperacute SARS-CoV-2 infection in rhesus macaques identified two populations of infiltrating macrophages as the primary orchestrators of inflammation in th elowre airway that can be successfully treated with baricitinib.
References: PMID: 34642693 / doi: 10.1101/2021.10.05.463212
Contact Info: Steven Bosinger: steven.bosinger@emory.edu; Mirko Paiardini: mirko.paiardini@emory.edu
URL: https://www.biorxiv.org/content/10.1101/2021.10.05.463212v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Pasteur Institute of Iran; University of Tehran; Biosunpharmed Co, Tehran; and others
Keywords: SARS-CoV-2, inactivated whole-virus vaccine, immune response, mice, guinea pig, rabbit and primates
Summary of Study: COVIran Barekat, an inactivated whole-virus SARS-CoV-2 candidate vaccine, elicited a high level of SARS-CoV-2 specific neutralizing antibodies in mice, rabbits, and rhesus macaques.
References: doi: 10.1101/2021.06.10.44.447951
Contact Info: Reza Aalizadeh: allizadehreza19@gmail.com; Hasan Jalili: hjalili@ut.ac.ir
URL: https://www.biorxiv.org/content/10.1101/2021.06.10.447951v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Pasteur Institute of Iran; University of Tehran; Biosunpharmed Co, Tehran; and others
Keywords: SARS-CoV-2, inactivated whole-virus vaccine, immune response, mice, guinea pig, rabbit and primates
Summary of Study: COVIran Barekat, an inactivated whole-virus SARS-CoV-2 candidate vaccine, elicited a high level of SARS-CoV-2 specific neutralizing antibodies in mice, rabbits, and rhesus macaques.
References: doi: 10.1101/2021.06.10.44.447951
Contact Info: Reza Aalizadeh: allizadehreza19@gmail.com; Hasan Jalili: hjalili@ut.ac.ir
URL: https://www.biorxiv.org/content/10.1101/2021.06.10.447951v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: ReiThera Sri, Rome, Italy; The University of Nottingham
Keywords: SARS-CoV-2, gorilla adenovirus-vectored vaccine, primates
Summary of Study: Vaccine candidate, GRAd-COV2, is highly immunogenic in both mice and cynomolgus macaques, eliciting both functional antibodies which neutralize SARS-CoV-2 infection and block Spike protein binding to the ACE2 receptor, and a robust, Th1-dominated cellular response in the periphery and in the lung.
References: doi: https://doi.org/10.1101/2020.10.22.349951
Contact Info: Alessandra Vitelli: alessandra.vitelli@reithera.com
URL: https://www.biorxiv.org/content/10.1101/2020.10.22.349951v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: ReiThera Sri, Rome, Italy; The University of Nottingham
Keywords: SARS-CoV-2, gorilla adenovirus-vectored vaccine, primates
Summary of Study: Vaccine candidate, GRAd-COV2, is highly immunogenic in both mice and cynomolgus macaques, eliciting both functional antibodies which neutralize SARS-CoV-2 infection and block Spike protein binding to the ACE2 receptor, and a robust, Th1-dominated cellular response in the periphery and in the lung.
References: doi: https://doi.org/10.1101/2020.10.22.349951
Contact Info: Alessandra Vitelli: alessandra.vitelli@reithera.com
URL: https://www.biorxiv.org/content/10.1101/2020.10.22.349951v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Sanofi Pasteur, GSK
Keywords: SARS-CoV-2, virus genomic variants, vaccine boosters, immune response, primates
Summary of Study: One booster dose of AS03-adjuvanted CoV2 preS dTM, D614 (parental) or B.1.351 (Beta), in monovalent of bivalent formulations, significantly booster pre-existing neutralizing antibodies and elicited high and stable cross-neutralizing antibodies covering the four known SARS-CV-2 variants of concern.
References: doi: 10.1101/2021.09.20.461023
Contact Info: Valerie Lecouturier: valerie.lecouturier@sanofi.com
URL: https://www.biorxiv.org/content/10.1101/2021.09.20.461023v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Sanofi Pasteur, GSK
Keywords: SARS-CoV-2, virus genomic variants, vaccine boosters, immune response, primates
Summary of Study: One booster dose of AS03-adjuvanted CoV2 preS dTM, D614 (parental) or B.1.351 (Beta), in monovalent of bivalent formulations, significantly booster pre-existing neutralizing antibodies and elicited high and stable cross-neutralizing antibodies covering the four known SARS-CV-2 variants of concern.
References: doi: 10.1101/2021.09.20.461023
Contact Info: Valerie Lecouturier: valerie.lecouturier@sanofi.com
URL: https://www.biorxiv.org/content/10.1101/2021.09.20.461023v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: SUNY Upstate Medical University; Walter Reed Army Institute of Research; NIAID; Henry M. Jackson Foundation for the Advancement of Military Medicine
Keywords: SARS-CoV-2, mRNA-1273 vaccine, single-cell transcriptomic profiling, virus variants, inflammation, primates
Summary of Study: Single cell RNA sequencing analysis demonstrates that mRNA-1273 vaccination limits the development of lower respiratory tract inflammation in SARS-CoV-2 challenged rhesus macaques.
References: doi: 10.1101/2021.12.24.474132
Contact Info: Robert Seder: rseder@mail.nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.12.24.474132v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: SUNY Upstate Medical University; Walter Reed Army Institute of Research; NIAID; Henry M. Jackson Foundation for the Advancement of Military Medicine
Keywords: SARS-CoV-2, mRNA-1273 vaccine, single-cell transcriptomic profiling, virus variants, inflammation, primates
Summary of Study: Single cell RNA sequencing analysis demonstrates that mRNA-1273 vaccination limits the development of lower respiratory tract inflammation in SARS-CoV-2 challenged rhesus macaques.
References: doi: 10.1101/2021.12.24.474132
Contact Info: Robert Seder: rseder@mail.nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.12.24.474132v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Duke University Medical Center, UNC- Chapel Hill, Louisiana State Univ., Infectious Disease Institute (Seattle, WA), Moderna, NIAID, California National Primate Research Center, Cornell Weill Medical College
Keywords: SARS-CoV-2, mRNA vaccine, nanoparticles, immune response, primates
Summary of Study: SARS-CoV-2 vaccines are well-tolerated and highly immunogenic in infant rhesus macaques.
References: PMID: 33851156 / doi: 10.1101/2021.04.05.438479
Contact Info: Kristina De Paris: abelk@med.unc.edu
URL: https://www.biorxiv.org/content/10.1101/2021.04.05.438479v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Duke University Medical Center, UNC- Chapel Hill, Louisiana State Univ., Infectious Disease Institute (Seattle, WA), Moderna, NIAID, California National Primate Research Center, Cornell Weill Medical College
Keywords: SARS-CoV-2, mRNA vaccine, nanoparticles, immune response, primates
Summary of Study: SARS-CoV-2 vaccines are well-tolerated and highly immunogenic in infant rhesus macaques.
References: PMID: 33851156 / doi: 10.1101/2021.04.05.438479
Contact Info: Kristina De Paris: abelk@med.unc.edu
URL: https://www.biorxiv.org/content/10.1101/2021.04.05.438479v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: Nat'l Institute of Infectious Diseases, Tokyo; University of Tokyo; Kumamoto University
Keywords: SARS-CoV-2, T cells, immune response, primates
Summary of Study: Study showed that subacute SARS-CoV-2 replication can be controlled even in the absence of CD8+ T cells. In SARS-CoV-2 infection, CD8+ T-cell responses may contribute to viral control, but these results suggest that CD8+ T-cell dysfunction does not solely lead to viral control failure or disease progression.
References: doi: 10.1101/2021.05.26.445769
Contact Info: Tesuro Matano: tmatano@nih.go.jp; Takushi Nomura: nomutako@nih.go.jp
URL: https://www.biorxiv.org/content/10.1101/2021.05.26.445769v1
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: Nat'l Institute of Infectious Diseases, Tokyo; University of Tokyo; Kumamoto University
Keywords: SARS-CoV-2, T cells, immune response, primates
Summary of Study: Study showed that subacute SARS-CoV-2 replication can be controlled even in the absence of CD8+ T cells. In SARS-CoV-2 infection, CD8+ T-cell responses may contribute to viral control, but these results suggest that CD8+ T-cell dysfunction does not solely lead to viral control failure or disease progression.
References: doi: 10.1101/2021.05.26.445769
Contact Info: Tesuro Matano: tmatano@nih.go.jp; Takushi Nomura: nomutako@nih.go.jp
URL: https://www.biorxiv.org/content/10.1101/2021.05.26.445769v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, marmosets
Year Published:
Study Type/Review:
NPRC/Institute: Department of Computational Medicine and Bioinformatics, University of Michigan
Keywords: SARS-CoV-2, a computational pipeline, the binding affinity ACE2, mammals, birds, fish, reptiles, and amphibians
Summary of Study: Identifying zoonotic origin of SARS-CoV-2 by modeling the binding affinity between Spike receptor-binding domain and host ACE2
References: doi: 10.1101/2020.09.11.293449
Contact Info: Yang Zhang: zhng@umich.edu
URL: https://www.biorxiv.org/content/10.1101/2020.09.11.293449v1
NHP Species: rhesus macaques, marmosets
Year Published:
Study Type/Review:
NPRC/Institute: Department of Computational Medicine and Bioinformatics, University of Michigan
Keywords: SARS-CoV-2, a computational pipeline, the binding affinity ACE2, mammals, birds, fish, reptiles, and amphibians
Summary of Study: Identifying zoonotic origin of SARS-CoV-2 by modeling the binding affinity between Spike receptor-binding domain and host ACE2
References: doi: 10.1101/2020.09.11.293449
Contact Info: Yang Zhang: zhng@umich.edu
URL: https://www.biorxiv.org/content/10.1101/2020.09.11.293449v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Fred Hutchinson Cancer Research Center
Keywords: SARS-CoV-2, Remdesivir, mathematical models, primates
Summary of Study: Developed a mathematical model to explain why remdesivir has a greater antiviral effect on SARS CoV-2 in lung versus nasal passages in rhesus macaque
References: doi: https://doi.org/10.1101/2020.06.21.163550
Contact Info: Joshua Schiffer, jschiffe@fredhutch.org
URL: https://www.biorxiv.org/content/10.1101/2020.06.21.163550v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Fred Hutchinson Cancer Research Center
Keywords: SARS-CoV-2, Remdesivir, mathematical models, primates
Summary of Study: Developed a mathematical model to explain why remdesivir has a greater antiviral effect on SARS CoV-2 in lung versus nasal passages in rhesus macaque
References: doi: https://doi.org/10.1101/2020.06.21.163550
Contact Info: Joshua Schiffer, jschiffe@fredhutch.org
URL: https://www.biorxiv.org/content/10.1101/2020.06.21.163550v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published:
Study Type/Review:
NPRC/Institute: University of TX Medical Branch
Keywords: SARS-CoV-2, convalescent sera, primates, viral load and disease pathology
Summary of Study: Groups of SARS-CoV-2 infected AGMs were treated with pooled convalescent sera containing either high or low to moderate anti-SARS-CoV-2 neutralizing antibody titers. Lower levels of SARS-CoV-2 in respiratory compartments, reduced gross and histopathological lesion severity in the lungs, and reductions in several parameters associated with coagulation and inflammatory processes were observed in monkeys that received convalescent sera versus untreated controls.
References: doi: https://doi.org/10.1101/2020.10.14.340091
Contact Info: Thomas Geisbert: twgeisbe@utmb.edu
URL: https://www.biorxiv.org/content/10.1101/2020.10.14.340091v1
NHP Species: african green monkeys
Year Published:
Study Type/Review:
NPRC/Institute: University of TX Medical Branch
Keywords: SARS-CoV-2, convalescent sera, primates, viral load and disease pathology
Summary of Study: Groups of SARS-CoV-2 infected AGMs were treated with pooled convalescent sera containing either high or low to moderate anti-SARS-CoV-2 neutralizing antibody titers. Lower levels of SARS-CoV-2 in respiratory compartments, reduced gross and histopathological lesion severity in the lungs, and reductions in several parameters associated with coagulation and inflammatory processes were observed in monkeys that received convalescent sera versus untreated controls.
References: doi: https://doi.org/10.1101/2020.10.14.340091
Contact Info: Thomas Geisbert: twgeisbe@utmb.edu
URL: https://www.biorxiv.org/content/10.1101/2020.10.14.340091v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School
Keywords: SARS-CoV-2, AAV-based, single dose vaccine, primates
Summary of Study: Two adeno-associated viral (AAV)-based vaccine candidates demonstrate potent immunogenicity in mouse and NHP models following a single injection. Moreover, the vaccine is stable at room temperature for a least one month and is produced at high yields using established commercial manufacturing processes in the gene therapy industry.
References: doi: https://doi.org/10.1101/2021.01.05.422952
Contact Info: Luk Vandenberghe: luk_vandenberghe@meei.harvard.edu
URL: https://www.biorxiv.org/content/10.1101/2021.01.05.422952v3
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School
Keywords: SARS-CoV-2, AAV-based, single dose vaccine, primates
Summary of Study: Two adeno-associated viral (AAV)-based vaccine candidates demonstrate potent immunogenicity in mouse and NHP models following a single injection. Moreover, the vaccine is stable at room temperature for a least one month and is produced at high yields using established commercial manufacturing processes in the gene therapy industry.
References: doi: https://doi.org/10.1101/2021.01.05.422952
Contact Info: Luk Vandenberghe: luk_vandenberghe@meei.harvard.edu
URL: https://www.biorxiv.org/content/10.1101/2021.01.05.422952v3
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: CNPRC/Vitalant
Keywords: SARS-CoV-2, protective immunity, CD4 helper cells, primates
Summary of Study: vaccine promoting Th1-type Tfh responses that target the S protein may lead to protective immunity
References: doi: 10.1101/2020.07.07.191007
Contact Info: Sonny Elizaldi, UC Davis CIID
URL: https://www.biorxiv.org/content/10.1101/2020.07.07.191007v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: CNPRC/Vitalant
Keywords: SARS-CoV-2, protective immunity, CD4 helper cells, primates
Summary of Study: vaccine promoting Th1-type Tfh responses that target the S protein may lead to protective immunity
References: doi: 10.1101/2020.07.07.191007
Contact Info: Sonny Elizaldi, UC Davis CIID
URL: https://www.biorxiv.org/content/10.1101/2020.07.07.191007v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: California National Primate Research Center; School of Medicine, UC Davis; Vitalant Research Institute; University of Colorado School of Medicine; University of California, Irvine; and others.
Keywords: SARS-CoV-2, convalescent plasma, intratracheal and intranasal routes, pathology, primates
Summary of Study: While administration of convalescent plasma (CCP) did not result in a detectable reduction in virus replication in the respiratory tract, it significantly reduced lung inflammation.
References: doi: 10.1101/2021.09.01.458520
Contact Info: Koen Van Rompay: kkvanrompay@ucdavis.edu; Michael Busch: mbusch@vitalant.org; J. Rachel Reader: rreader@ucdavis.edu
URL: https://www.biorxiv.org/content/10.1101/2021.09.01.458520v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: California National Primate Research Center; School of Medicine, UC Davis; Vitalant Research Institute; University of Colorado School of Medicine; University of California, Irvine; and others.
Keywords: SARS-CoV-2, convalescent plasma, intratracheal and intranasal routes, pathology, primates
Summary of Study: While administration of convalescent plasma (CCP) did not result in a detectable reduction in virus replication in the respiratory tract, it significantly reduced lung inflammation.
References: doi: 10.1101/2021.09.01.458520
Contact Info: Koen Van Rompay: kkvanrompay@ucdavis.edu; Michael Busch: mbusch@vitalant.org; J. Rachel Reader: rreader@ucdavis.edu
URL: https://www.biorxiv.org/content/10.1101/2021.09.01.458520v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute, Henry M. Jackson Foundation for the Advancement of Military Medicine, NCI, BIOQUAL, Texas Biomedical Research Institute, Columbia University
Keywords: SARS-CoV-2, ferritin nanoparticle vaccine, immune response, primates
Summary of Study: Evaluation of a SARS-CoV-2 Spike receptor-binding doman ferritin nanoparticle protein vaccine (RFN), adjuvanted with a liposomal-QS21 formulation (ALFQ) elicits humoral and cellular immune responses exceeding those of current vaccines.
References: PMID: 33851155 / doi: 10.1101/2021.04.09.439166
Contact Info: Diane Bolton: dbolton@hivresearch.org; Kayvon Modjarrad: kayvon.modjarrad.cov@mail.mil
URL: https://www.biorxiv.org/content/10.1101/2021.04.09.439166v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute, Henry M. Jackson Foundation for the Advancement of Military Medicine, NCI, BIOQUAL, Texas Biomedical Research Institute, Columbia University
Keywords: SARS-CoV-2, ferritin nanoparticle vaccine, immune response, primates
Summary of Study: Evaluation of a SARS-CoV-2 Spike receptor-binding doman ferritin nanoparticle protein vaccine (RFN), adjuvanted with a liposomal-QS21 formulation (ALFQ) elicits humoral and cellular immune responses exceeding those of current vaccines.
References: PMID: 33851155 / doi: 10.1101/2021.04.09.439166
Contact Info: Diane Bolton: dbolton@hivresearch.org; Kayvon Modjarrad: kayvon.modjarrad.cov@mail.mil
URL: https://www.biorxiv.org/content/10.1101/2021.04.09.439166v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: COVAXX, United Biomedical< Inc., United BioPharma, Academic Sinica, University of Texas Medical Branch, Galveston National Library
Keywords: SARS-CoV-2, multitope protein-peptide vaccine, immune response, toxicity, protection, guinea pigs, rats, primates
Summary of Study: The authors have developed and demonstrated proof of concept for UB-612, a novel multitope protein-peptide vaccine being rapidly advanced in clinical trials for prevention of SARS-CoV-2 infection and COVID-19. Extremely high levels of neutralizing antibodies were shown and Th1 prone immune response was induced by the vaccine that protected animals, challenged by a high dose of SARS-CoV-2, without induction of immunopathology in the lungs.
References: doi: 10.1101/2020.11.30.399154
Contact Info: Chang Yi Wang: cywang@unitedbiomedical.com
URL: https://www.biorxiv.org/content/10.1101/2020.11.30.399154v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: COVAXX, United Biomedical< Inc., United BioPharma, Academic Sinica, University of Texas Medical Branch, Galveston National Library
Keywords: SARS-CoV-2, multitope protein-peptide vaccine, immune response, toxicity, protection, guinea pigs, rats, primates
Summary of Study: The authors have developed and demonstrated proof of concept for UB-612, a novel multitope protein-peptide vaccine being rapidly advanced in clinical trials for prevention of SARS-CoV-2 infection and COVID-19. Extremely high levels of neutralizing antibodies were shown and Th1 prone immune response was induced by the vaccine that protected animals, challenged by a high dose of SARS-CoV-2, without induction of immunopathology in the lungs.
References: doi: 10.1101/2020.11.30.399154
Contact Info: Chang Yi Wang: cywang@unitedbiomedical.com
URL: https://www.biorxiv.org/content/10.1101/2020.11.30.399154v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: The 4th R&D Institute, Agency for Defense Development, Yuseong, P.O. Box 35, Daejeon 34186, Republic of Korea
Keywords: SARS-CoV-2, siRNA inhibitors, hamster and primates
Summary of Study: An siRNA targeting RNA-dependent RNA polymerase (RdRp) showed a reduction in SARS-CoV-2 infection-induced fever and virus titer in the Golden Syrian hamster and rhesus macaque. These results suggest the potential for RdRp targeting siRNA as a new treatment for the coronavirus disease 2019 (COVID-19).
References: doi: https://doi.org/10.1101/2020.07.07.190967
Contact Info: Seong Tae Jeong at birdyjeong@add.re.kr
URL: https://www.biorxiv.org/content/10.1101/2020.07.07.190967v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: The 4th R&D Institute, Agency for Defense Development, Yuseong, P.O. Box 35, Daejeon 34186, Republic of Korea
Keywords: SARS-CoV-2, siRNA inhibitors, hamster and primates
Summary of Study: An siRNA targeting RNA-dependent RNA polymerase (RdRp) showed a reduction in SARS-CoV-2 infection-induced fever and virus titer in the Golden Syrian hamster and rhesus macaque. These results suggest the potential for RdRp targeting siRNA as a new treatment for the coronavirus disease 2019 (COVID-19).
References: doi: https://doi.org/10.1101/2020.07.07.190967
Contact Info: Seong Tae Jeong at birdyjeong@add.re.kr
URL: https://www.biorxiv.org/content/10.1101/2020.07.07.190967v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Medicago, Inc.; Stanford University; Tulane University School of Medicine; McGill University
Keywords: SARS-CoV-2, plant-derived virus-like particle vaccine, immune response, pathology, primates
Summary of Study: Although a single dose of an unadjuvanted virus-like particle (VLP) bearing SARS-CoV-2 spike protein vaccine candidate stimulated humoral and cell-mediated immune responses, booster immunization (at 28 days after prime) and adjuvants significantly improved both responses with a higher immunogenicity and protection provided by AS03 adjuvanted CoVLP.
References: doi: 10.1101.2021.05.15.444262
Contact Info: Nathalie Landry: landryn@medicago.com
URL: https://www.biorxiv.org/content/10.1101/2021.05.15.444262v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Medicago, Inc.; Stanford University; Tulane University School of Medicine; McGill University
Keywords: SARS-CoV-2, plant-derived virus-like particle vaccine, immune response, pathology, primates
Summary of Study: Although a single dose of an unadjuvanted virus-like particle (VLP) bearing SARS-CoV-2 spike protein vaccine candidate stimulated humoral and cell-mediated immune responses, booster immunization (at 28 days after prime) and adjuvants significantly improved both responses with a higher immunogenicity and protection provided by AS03 adjuvanted CoVLP.
References: doi: 10.1101.2021.05.15.444262
Contact Info: Nathalie Landry: landryn@medicago.com
URL: https://www.biorxiv.org/content/10.1101/2021.05.15.444262v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: Duke NUS Medical School, Singapore; Duke University Medical School
Keywords: SARS-CoV-2, lung inflammation, pathology, mice and primates
Summary of Study: Widespread degranulation of mast cells (MCs) during acute and unresolved airway inflammation in SARS-CoV-2-infected mice and non-human primates supports the association of MC activation with severe COVID-19 and suggests potential strategies for intervention.
References: PMID: 34100020 / doi: 10.1101.2021.05.31.21255594
Contact Info: Ashley St. John: ashley.st.john@duke.nus.edu.sg
URL: https://www.medrxiv.org/content/10.1101/2021.05.31.21255594v1
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: Duke NUS Medical School, Singapore; Duke University Medical School
Keywords: SARS-CoV-2, lung inflammation, pathology, mice and primates
Summary of Study: Widespread degranulation of mast cells (MCs) during acute and unresolved airway inflammation in SARS-CoV-2-infected mice and non-human primates supports the association of MC activation with severe COVID-19 and suggests potential strategies for intervention.
References: PMID: 34100020 / doi: 10.1101.2021.05.31.21255594
Contact Info: Ashley St. John: ashley.st.john@duke.nus.edu.sg
URL: https://www.medrxiv.org/content/10.1101/2021.05.31.21255594v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: NIAID/NIH; The Jenner Institute at the University of Oxford
Keywords: SARS-CoV-2, multiomics profiling, young and old animals, immune response, primates
Summary of Study: Despite similar disease outcomes, multi-omics profiling in SARS-CoV-2-infected rhesus macaques suggests that age may delay or impair the induction of anti-viral cellular immune responses and delay efficient return to immune homeostasis following acute infection.
References: doi: 10.1101/2021.09.08.459430
Contact Info: Emmie de Wit: emmie.dewit@nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.09.08.459430v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: NIAID/NIH; The Jenner Institute at the University of Oxford
Keywords: SARS-CoV-2, multiomics profiling, young and old animals, immune response, primates
Summary of Study: Despite similar disease outcomes, multi-omics profiling in SARS-CoV-2-infected rhesus macaques suggests that age may delay or impair the induction of anti-viral cellular immune responses and delay efficient return to immune homeostasis following acute infection.
References: doi: 10.1101/2021.09.08.459430
Contact Info: Emmie de Wit: emmie.dewit@nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.09.08.459430v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: National Institute of Infectious Diseases, Tokyo, Japan
Keywords: SARS-CoV-2, T-cell populations, primates
Summary of Study: Results suggest that the peripheral T lymphocyte population is associated with pneumonia severity in cynomolgus monkeys experimentally infected with SARS-CoV-2.
References: doi: https://doi.org/10.1101/2021.01.07.425698
Contact Info: Noriyo Nagata: nnagata@nih.go.jp
URL: https://www.biorxiv.org/content/10.1101/2021.01.07.425698v1
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: National Institute of Infectious Diseases, Tokyo, Japan
Keywords: SARS-CoV-2, T-cell populations, primates
Summary of Study: Results suggest that the peripheral T lymphocyte population is associated with pneumonia severity in cynomolgus monkeys experimentally infected with SARS-CoV-2.
References: doi: https://doi.org/10.1101/2021.01.07.425698
Contact Info: Noriyo Nagata: nnagata@nih.go.jp
URL: https://www.biorxiv.org/content/10.1101/2021.01.07.425698v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: ImmunityBio, Culver City, CA
Keywords: SARS-CoV-2, prime and oral boost bivalent hAd5 vaccination, T-cell response, primates
Summary of Study: Treatment with bivalent hAd5S-Fusion + N-ETSD subcutaneous and oral vaccine provided complete protection of nasal and lung airways against SARS-CoV-2 challenge in rhesus macaques. Data demonstrate that all NHPs immunized with the hAD5 S-Fusion + N-ETSD vaccine generated anti-S IgG and that 9 of 10 animals showed inhibition in cPass (TM) and thus the presence of anti-S RBD neutralizing antibodies.
References: doi: https://doi.org/10.1101/2020.12.08.416297
Contact Info: Patrick Soon-Shiong: patrick@nantworks.com
URL: https://www.biorxiv.org/content/10.1101/2020.12.08.416297v3
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: ImmunityBio, Culver City, CA
Keywords: SARS-CoV-2, prime and oral boost bivalent hAd5 vaccination, T-cell response, primates
Summary of Study: Treatment with bivalent hAd5S-Fusion + N-ETSD subcutaneous and oral vaccine provided complete protection of nasal and lung airways against SARS-CoV-2 challenge in rhesus macaques. Data demonstrate that all NHPs immunized with the hAD5 S-Fusion + N-ETSD vaccine generated anti-S IgG and that 9 of 10 animals showed inhibition in cPass (TM) and thus the presence of anti-S RBD neutralizing antibodies.
References: doi: https://doi.org/10.1101/2020.12.08.416297
Contact Info: Patrick Soon-Shiong: patrick@nantworks.com
URL: https://www.biorxiv.org/content/10.1101/2020.12.08.416297v3
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: University of Bern
Keywords: SARS-CoV-2, airway epithelial cell (AEC) culture repository, multiple animal species
Summary of Study: Well-differentiated primary airway epithelial cell cultures were established from various domestic and wildlife animal species (including rhesus macaques) to assess the potential intermediate and spillback host reservoir spectrum of SARS-CoV-2. rhesus macaque post-mortem tracheobronchial airway tissue material. These were inoculated with SARS-CoV-2/Munchen-1.1/2020/929 isolate and monitored for viral titer for 96 hours. Infectious progeny virus were absent in most species, except rhesus macaques and cats, indicating that some species are not ideally suited as animal models in studies of SARS-CoV-2.
References: doi: https://doi.org/10.1101/2020.11.10.374587
Contact Info: Ronald Dijkman: ronald.dijkman@ifik.unibe.ch
URL: https://www.biorxiv.org/content/10.1101/2020.11.10.374587v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: University of Bern
Keywords: SARS-CoV-2, airway epithelial cell (AEC) culture repository, multiple animal species
Summary of Study: Well-differentiated primary airway epithelial cell cultures were established from various domestic and wildlife animal species (including rhesus macaques) to assess the potential intermediate and spillback host reservoir spectrum of SARS-CoV-2. rhesus macaque post-mortem tracheobronchial airway tissue material. These were inoculated with SARS-CoV-2/Munchen-1.1/2020/929 isolate and monitored for viral titer for 96 hours. Infectious progeny virus were absent in most species, except rhesus macaques and cats, indicating that some species are not ideally suited as animal models in studies of SARS-CoV-2.
References: doi: https://doi.org/10.1101/2020.11.10.374587
Contact Info: Ronald Dijkman: ronald.dijkman@ifik.unibe.ch
URL: https://www.biorxiv.org/content/10.1101/2020.11.10.374587v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: National Institute of Allergy and Infectious Diseases, National Institutes of Health
Keywords: SARS-CoV-2, virus variants, pathology, immune response, primates
Summary of Study: Disease severity among variants is unequal, with a lower viral load and thus reduced clinical disease in Omicron versus Delta variants.
References: PMID: 35971544 / doi: 10.1101/2022.08.01.502390
Contact Info: Neeltje van Doremalen: neeltje.vandoremalen@nih.gov; Kyle Rosenke: kyle.rosenke@nih.gov
URL: https://www.biorxiv.org/content/10.1101/2022.08.01.502390v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: National Institute of Allergy and Infectious Diseases, National Institutes of Health
Keywords: SARS-CoV-2, virus variants, pathology, immune response, primates
Summary of Study: Disease severity among variants is unequal, with a lower viral load and thus reduced clinical disease in Omicron versus Delta variants.
References: PMID: 35971544 / doi: 10.1101/2022.08.01.502390
Contact Info: Neeltje van Doremalen: neeltje.vandoremalen@nih.gov; Kyle Rosenke: kyle.rosenke@nih.gov
URL: https://www.biorxiv.org/content/10.1101/2022.08.01.502390v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: National Institute of Allergy and Infectious Disease, NIH; University of California- Berkely; La Jolla Institute for Immunology; University of California - San Diego; University of Cape Town - Observatory
Keywords: SARS-CoV-2, IFN? and IL-10, immune response, viral replication, primates
Summary of Study: There are no major effects of the pro- and anti-inflammatory pathways in COVID-19 infection, but IL-10, an anti-inflammatory cytokine, has a role in suppressing the acculmulation of T-cells specific to infection in the lower airways.
References: PMID: 36172119 / doi: 10.1101/2022.09.13.507852
Contact Info: Daniel Barber: barberd@niaid.nih.gov
URL: https://www.biorxiv.org/content/10.1101/2022.09.13.507852v2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: National Institute of Allergy and Infectious Disease, NIH; University of California- Berkely; La Jolla Institute for Immunology; University of California - San Diego; University of Cape Town - Observatory
Keywords: SARS-CoV-2, IFN? and IL-10, immune response, viral replication, primates
Summary of Study: There are no major effects of the pro- and anti-inflammatory pathways in COVID-19 infection, but IL-10, an anti-inflammatory cytokine, has a role in suppressing the acculmulation of T-cells specific to infection in the lower airways.
References: PMID: 36172119 / doi: 10.1101/2022.09.13.507852
Contact Info: Daniel Barber: barberd@niaid.nih.gov
URL: https://www.biorxiv.org/content/10.1101/2022.09.13.507852v2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Emory, Tulane, Washington and Oregon National Primate Research Centers; Emory University School of Medicine; Weissman Institute of Science, Israel; Ulm University Medical Center, Germany, and others.
Keywords: SARS-CoV-2, IFN-I signaling, inflammasome activation, primates
Summary of Study: Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques
References: doi: 10.1101/2022.10.21.512606
Contact Info: Mirko Paiardini: mirko.paiardini@emory.edu
URL: https://www.biorxiv.org/content/10.1101/2022.10.21.512606v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Emory, Tulane, Washington and Oregon National Primate Research Centers; Emory University School of Medicine; Weissman Institute of Science, Israel; Ulm University Medical Center, Germany, and others.
Keywords: SARS-CoV-2, IFN-I signaling, inflammasome activation, primates
Summary of Study: Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques
References: doi: 10.1101/2022.10.21.512606
Contact Info: Mirko Paiardini: mirko.paiardini@emory.edu
URL: https://www.biorxiv.org/content/10.1101/2022.10.21.512606v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA; others
Keywords: SARS-CoV-2, receptor-binding domain, mosaic nanoparticles, immune response, rodents, primates
Summary of Study: Mosaic sarbecovirus vaccination elicits cross-reactive responses
References: PMID: 38370696 PMCID: PMC10871317 DOI: 10.1101/2024.02.08.576722
Contact Info: Pamela Bjorkman: bjorkman@caltech.edu
URL: https://www.biorxiv.org/content/10.1101/2024.02.08.576722v1
NHP Species: cynomolgus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA; others
Keywords: SARS-CoV-2, receptor-binding domain, mosaic nanoparticles, immune response, rodents, primates
Summary of Study: Mosaic sarbecovirus vaccination elicits cross-reactive responses
References: PMID: 38370696 PMCID: PMC10871317 DOI: 10.1101/2024.02.08.576722
Contact Info: Pamela Bjorkman: bjorkman@caltech.edu
URL: https://www.biorxiv.org/content/10.1101/2024.02.08.576722v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: COVAXX, Inc.; United Biomedical Inc., Asia; United BioPharma; United Biomedical Inc., USA; Academia Sinica; University of Texas Medical Branch; Galveston National Laboratory
Keywords: SARS-CoV-2, multitope protein-peptide vaccine, immunogenicity, protection, mice, rats, Guinea pigs, primates
Summary of Study: With a Phase 1 trial ongoing in Taiwan and additional trials planned worldwide, UB-612 is a highly promising and differentiated vaccine candidate for prevention of SARS-CoV-2 transmisison and COVID-19 disease.
References: doi: 10.1101/2020.11.30.399154
Contact Info: Chang Yi Wang: cywang@unitedbiomedical.com
URL: https://www.biorxiv.org/content/10.1101/2020.11.30.399154v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: COVAXX, Inc.; United Biomedical Inc., Asia; United BioPharma; United Biomedical Inc., USA; Academia Sinica; University of Texas Medical Branch; Galveston National Laboratory
Keywords: SARS-CoV-2, multitope protein-peptide vaccine, immunogenicity, protection, mice, rats, Guinea pigs, primates
Summary of Study: With a Phase 1 trial ongoing in Taiwan and additional trials planned worldwide, UB-612 is a highly promising and differentiated vaccine candidate for prevention of SARS-CoV-2 transmisison and COVID-19 disease.
References: doi: 10.1101/2020.11.30.399154
Contact Info: Chang Yi Wang: cywang@unitedbiomedical.com
URL: https://www.biorxiv.org/content/10.1101/2020.11.30.399154v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: IRSICaixa AIDS Research Institute; Barcelona Institute of Science & Technology; Yerkes National Primate Research Center, Emory University, and more
Keywords: SARS-CoV-2, antigen presenting myeloid cells, pathology, primates
Summary of Study: Although being largely resistant to SARS-CoV-2 infection, myeloid cells effectively capture and trap incoming viruses in internal compartments connected with the plasma membrane, eventually leading to viral degradation over time.
References: doi: 10.1101/2021.05.11.443572
Contact Info: Javier Martinez/Picado: jmpicado@irsicaixa.es; Julia Vergara-Alert: julia.vergara@irta.cat
URL: https://www.biorxiv.org/content/10.1101/2021.05.11.443572v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: IRSICaixa AIDS Research Institute; Barcelona Institute of Science & Technology; Yerkes National Primate Research Center, Emory University, and more
Keywords: SARS-CoV-2, antigen presenting myeloid cells, pathology, primates
Summary of Study: Although being largely resistant to SARS-CoV-2 infection, myeloid cells effectively capture and trap incoming viruses in internal compartments connected with the plasma membrane, eventually leading to viral degradation over time.
References: doi: 10.1101/2021.05.11.443572
Contact Info: Javier Martinez/Picado: jmpicado@irsicaixa.es; Julia Vergara-Alert: julia.vergara@irta.cat
URL: https://www.biorxiv.org/content/10.1101/2021.05.11.443572v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Meissa Vaccines, Inc., BIOQUAL, Inc., University of Texas Medical Branch, Butler University, Vanderbilt University School of Medicine
Keywords: SARS-CoV-2, vaccine candidate, immune response, virus variants, primate
Summary of Study: One mucosal administration of MV-014-212 in African green monkeys protected against SARS-CoV-2 challenge. Intranasally delivered, live attenuated vaccines such as MV-014-212 entail low-cost manufacturing suitable for global deployment. MV-014-212 is currently in Phase I clinical trials as a single-dose intranasal COVID-19 vaccine.
References: doi: 10.1101/2021.07.16.452733
Contact Info: Mariana Tioni: mariana.tioni@meissavaccines.com
URL: https://www.biorxiv.org/content/10.1101/2021.07.16.452733v2
NHP Species: african green monkeys
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Meissa Vaccines, Inc., BIOQUAL, Inc., University of Texas Medical Branch, Butler University, Vanderbilt University School of Medicine
Keywords: SARS-CoV-2, vaccine candidate, immune response, virus variants, primate
Summary of Study: One mucosal administration of MV-014-212 in African green monkeys protected against SARS-CoV-2 challenge. Intranasally delivered, live attenuated vaccines such as MV-014-212 entail low-cost manufacturing suitable for global deployment. MV-014-212 is currently in Phase I clinical trials as a single-dose intranasal COVID-19 vaccine.
References: doi: 10.1101/2021.07.16.452733
Contact Info: Mariana Tioni: mariana.tioni@meissavaccines.com
URL: https://www.biorxiv.org/content/10.1101/2021.07.16.452733v2
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published:
Study Type/Review:
NPRC/Institute: Selva Therapeutics, Tulane National Primate Research Center, University of Texas Medical Branch, UC San Diego,
Keywords: SARS-CoV-2,cysteine protease inhibitors, antiviral effects, pathology, primates
Summary of Study: SLV is an orally available treatment likely to reduce the respiratory symptoms associated with clinical progression in COVID-19 patients. African green monkey studies with this drug demonstrated a reduction in lung weight and a reduction in coronavirus-mediated pathology in both prophylactic and treatment settings. A Phase I trial with SLV213 has recently been completed and a Phase II trial is planned (https://clinicaltrials.gov/ct2/show/NCT04843787).
References: doi: 10.1101/2021.07.20.453127
Contact Info: Felix Frueh: ffrueh@selvarx.com
URL: https://www.biorxiv.org/content/10.1101/2021.07.20.453127v1
NHP Species: african green monkeys
Year Published:
Study Type/Review:
NPRC/Institute: Selva Therapeutics, Tulane National Primate Research Center, University of Texas Medical Branch, UC San Diego,
Keywords: SARS-CoV-2,cysteine protease inhibitors, antiviral effects, pathology, primates
Summary of Study: SLV is an orally available treatment likely to reduce the respiratory symptoms associated with clinical progression in COVID-19 patients. African green monkey studies with this drug demonstrated a reduction in lung weight and a reduction in coronavirus-mediated pathology in both prophylactic and treatment settings. A Phase I trial with SLV213 has recently been completed and a Phase II trial is planned (https://clinicaltrials.gov/ct2/show/NCT04843787).
References: doi: 10.1101/2021.07.20.453127
Contact Info: Felix Frueh: ffrueh@selvarx.com
URL: https://www.biorxiv.org/content/10.1101/2021.07.20.453127v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Gritstone Bio., Inc.; Battelle Biomedical Research Center
Keywords: SARS-CoV-2, prime-boost vaccination, immune response, primates
Summary of Study: Data demonstrate that the Self-amplifying mRNA (SAM) vaccine platform can drive balanced T- and B-cell responses for optimal protective immunity at low doses, offering an additional attractive vaccine platform in the fight against current and emerging infectious pathogens.
References: doi:10.1101/2021.11.08.467773
Contact Info: Karin Jooss: kjooss@gritstone.com
URL: https://www.biorxiv.org/content/10.1101/2021.11.08.467773v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Gritstone Bio., Inc.; Battelle Biomedical Research Center
Keywords: SARS-CoV-2, prime-boost vaccination, immune response, primates
Summary of Study: Data demonstrate that the Self-amplifying mRNA (SAM) vaccine platform can drive balanced T- and B-cell responses for optimal protective immunity at low doses, offering an additional attractive vaccine platform in the fight against current and emerging infectious pathogens.
References: doi:10.1101/2021.11.08.467773
Contact Info: Karin Jooss: kjooss@gritstone.com
URL: https://www.biorxiv.org/content/10.1101/2021.11.08.467773v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Inovio Pharmaceuticals; The Wistar Institute
Keywords: SARS-CoV-2, DNA vaccine candidate, immunogenicity, boost, primates
Summary of Study: Data illustrate the durability of immunity following vaccination with synthetic DNA vaccine candidates INO-4800 or INP-4802 and additional support the use of either INO-4800 or INP-4802 in prime-boost regimens.
References: doi: 10.1101/2021.10.27.466163
Contact Info: Kate Broderick: kate.broderick@inovio.com; David Weiner: dweiner@wistar.org
URL: https://www.biorxiv.org/content/10.1101/2021.10.27.466163v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Inovio Pharmaceuticals; The Wistar Institute
Keywords: SARS-CoV-2, DNA vaccine candidate, immunogenicity, boost, primates
Summary of Study: Data illustrate the durability of immunity following vaccination with synthetic DNA vaccine candidates INO-4800 or INP-4802 and additional support the use of either INO-4800 or INP-4802 in prime-boost regimens.
References: doi: 10.1101/2021.10.27.466163
Contact Info: Kate Broderick: kate.broderick@inovio.com; David Weiner: dweiner@wistar.org
URL: https://www.biorxiv.org/content/10.1101/2021.10.27.466163v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Oyster Point Pharma; Trudeau Institute
Keywords: SARS-CoV-2, varenicline tartrate, invitro and in vivo studies, virus infection, primates
Summary of Study: The nAChR agonist varenicline has the potential to interact with and inhibit SARS-CoV-2 infection and replication.
References: doi: 10.1101/2021.06.29.450426
Contact Info: Jeffrey Nau: jnau@oysterpointrx.com
URL: https://www.biorxiv.org/content/10.1101/2021.06.29.450426v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Oyster Point Pharma; Trudeau Institute
Keywords: SARS-CoV-2, varenicline tartrate, invitro and in vivo studies, virus infection, primates
Summary of Study: The nAChR agonist varenicline has the potential to interact with and inhibit SARS-CoV-2 infection and replication.
References: doi: 10.1101/2021.06.29.450426
Contact Info: Jeffrey Nau: jnau@oysterpointrx.com
URL: https://www.biorxiv.org/content/10.1101/2021.06.29.450426v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Sanofi Pasteur
Keywords: SARS-CoV-2, mRNA vaccine candidates, primates
Summary of Study: Several mRNA constructs expressing various structural conformations of S-protein were tested in cynomolgus macaques for their capacity to elicit neutralizing antibodies. The candidate MRT5500 was shown to be immunogenic by eliciting potent neutralizing antibodies in both mice and cynomolgus macaques and is position for further development in clinical studies as a vaccine for the prevention of COVID-19.
References: doi: https://doi.org/10.1101/2020.10.14.337535
Contact Info: none listed
URL: https://www.biorxiv.org/content/10.1101/2020.10.14.337535v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Sanofi Pasteur
Keywords: SARS-CoV-2, mRNA vaccine candidates, primates
Summary of Study: Several mRNA constructs expressing various structural conformations of S-protein were tested in cynomolgus macaques for their capacity to elicit neutralizing antibodies. The candidate MRT5500 was shown to be immunogenic by eliciting potent neutralizing antibodies in both mice and cynomolgus macaques and is position for further development in clinical studies as a vaccine for the prevention of COVID-19.
References: doi: https://doi.org/10.1101/2020.10.14.337535
Contact Info: none listed
URL: https://www.biorxiv.org/content/10.1101/2020.10.14.337535v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Northwestern University Feinberg School of Medicine; Tulane National Primate Research Center; New Iberia Research Center
Keywords: SARS-CoV-2, male genital tract, positron emission tomography, pathogenesis, primates
Summary of Study: Results suggest that SARS-CoV-2 rapidly and efficiently infects multiple tissues of the male genital tract (MGT) early during infection in rhesus macaques.
References: PMID: 35262081 / doi: 10.1101/2022.02.25.481974
Contact Info: Thomas J. Hope: thope@northwestern.edu
URL: https://www.biorxiv.org/content/10.1101/2022.02.25.481974v2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Northwestern University Feinberg School of Medicine; Tulane National Primate Research Center; New Iberia Research Center
Keywords: SARS-CoV-2, male genital tract, positron emission tomography, pathogenesis, primates
Summary of Study: Results suggest that SARS-CoV-2 rapidly and efficiently infects multiple tissues of the male genital tract (MGT) early during infection in rhesus macaques.
References: PMID: 35262081 / doi: 10.1101/2022.02.25.481974
Contact Info: Thomas J. Hope: thope@northwestern.edu
URL: https://www.biorxiv.org/content/10.1101/2022.02.25.481974v2
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Perelman School of medicine; University of Wisconsin-Medison; The Children's Hospital of Philadelphia; Cardiomyogen; ORRA Group, LLC; Stanford University, and others
Keywords: SARS-CoV-2, AAV vectors, immunization, immune response, mice, primates
Summary of Study: These studies demonstrate not only that AAV6 and AAV9 can function as effective vaccine platforms, but also that vaccine can provide long-term efficacy primarily through the induction of cellular immunity.
References: doi: 10.1101/2021.08.16.456441
Contact Info: Hansell Stedman: hstedman@mail.med.upenn.edu
URL: https://www.biorxiv.org/content/10.1101/2021.08.16.456441v1.article-metrics
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Perelman School of medicine; University of Wisconsin-Medison; The Children's Hospital of Philadelphia; Cardiomyogen; ORRA Group, LLC; Stanford University, and others
Keywords: SARS-CoV-2, AAV vectors, immunization, immune response, mice, primates
Summary of Study: These studies demonstrate not only that AAV6 and AAV9 can function as effective vaccine platforms, but also that vaccine can provide long-term efficacy primarily through the induction of cellular immunity.
References: doi: 10.1101/2021.08.16.456441
Contact Info: Hansell Stedman: hstedman@mail.med.upenn.edu
URL: https://www.biorxiv.org/content/10.1101/2021.08.16.456441v1.article-metrics
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Yerkes National Primate Research Center; University of Pittsburgh; Emory University School of Medicine
Keywords: SARS-CoV-2, macrophages, inflammation, mRNA analysis, kinase inhibitor, primates
Summary of Study: Multi-omic analyses of hyperacute SARS-CoV-2 infection in rhesus macaques identified two populations of infiltrating macrophages as the primary orchestrators of inflammation in the lower airway that can be successfully treated with baricitinib.
References: doi: 10.1101/2021.10.05.463212
Contact Info: Steven Bosinger: steven.bosinger@emory.edu; Mirko Paiardini: mirko.paiardini@emory.edu
URL: https://www.biorxiv.org/content/10.1101/2021.10.05.463212v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Yerkes National Primate Research Center; University of Pittsburgh; Emory University School of Medicine
Keywords: SARS-CoV-2, macrophages, inflammation, mRNA analysis, kinase inhibitor, primates
Summary of Study: Multi-omic analyses of hyperacute SARS-CoV-2 infection in rhesus macaques identified two populations of infiltrating macrophages as the primary orchestrators of inflammation in the lower airway that can be successfully treated with baricitinib.
References: doi: 10.1101/2021.10.05.463212
Contact Info: Steven Bosinger: steven.bosinger@emory.edu; Mirko Paiardini: mirko.paiardini@emory.edu
URL: https://www.biorxiv.org/content/10.1101/2021.10.05.463212v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Laboratory of Virology (NIAID/NIH), Rocky Mountain Veterinary Branch (NIAID/NIH), CureVac AG
Keywords: SARS-CoV-2, mRNA vaccine candidate, humoral and cellular immune responses, primates
Summary of Study: A new SARS-CoV-2 S mRNA vaccine, CV07050101 was investigated in NHPs. Prime-boost vaccination of rhesus macaques with 4 ug of CV07050101 does not elicit a uniform nor robust immune response; however, vaccination using 8 ug of the same vaccine demonstrated protection.
References: PMID: 34268507 / doi: 10.1101/202.07.07.451505
Contact Info: Vincent Munster: vincent.munster@nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.07.07.451505v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Laboratory of Virology (NIAID/NIH), Rocky Mountain Veterinary Branch (NIAID/NIH), CureVac AG
Keywords: SARS-CoV-2, mRNA vaccine candidate, humoral and cellular immune responses, primates
Summary of Study: A new SARS-CoV-2 S mRNA vaccine, CV07050101 was investigated in NHPs. Prime-boost vaccination of rhesus macaques with 4 ug of CV07050101 does not elicit a uniform nor robust immune response; however, vaccination using 8 ug of the same vaccine demonstrated protection.
References: PMID: 34268507 / doi: 10.1101/202.07.07.451505
Contact Info: Vincent Munster: vincent.munster@nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.07.07.451505v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Scripps Research Institute; MIT; UCSD; Howard Hughes Medican Institute
Keywords: SARS-CoV-2, receptor-binding domain vaccine, structural studies, immune response, primates
Summary of Study: Broadly neutralizing antibodies to an unappreciated site of conservation in the RBD in SARS-related viruses can be readily induced in rhesus macaques because of distinct properties of the naive macaque B cell repertoire that suggest prudence in the use of the macaque model in SARS vaccine evaluation and design.
References: doi: 10.1101/2021.07.05.451222
Contact Info: Ian Wilson: wilson@scripps.edu; Dennis Burton: burton@scripps.edu; Raiees Andrabi: andrabi@scripps.edu
URL: https://www.biorxiv.org/content/10.1101/2021.07.05.451222v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Scripps Research Institute; MIT; UCSD; Howard Hughes Medican Institute
Keywords: SARS-CoV-2, receptor-binding domain vaccine, structural studies, immune response, primates
Summary of Study: Broadly neutralizing antibodies to an unappreciated site of conservation in the RBD in SARS-related viruses can be readily induced in rhesus macaques because of distinct properties of the naive macaque B cell repertoire that suggest prudence in the use of the macaque model in SARS vaccine evaluation and design.
References: doi: 10.1101/2021.07.05.451222
Contact Info: Ian Wilson: wilson@scripps.edu; Dennis Burton: burton@scripps.edu; Raiees Andrabi: andrabi@scripps.edu
URL: https://www.biorxiv.org/content/10.1101/2021.07.05.451222v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Peking University Health Science Center, Beijing, China
Keywords: SARS-CoV-2, TLR4, trimeric spike protein binding, primates
Summary of Study: The spike protein of SARS-CoV-2 functions as a potent stimulus causing TLR4 activation and sepsis related abnormal responses.
References: doi: https://doi.org/10.1101/2020.12.18.423427
Contact Info: Xiangxi Wang: xiangxi@idp.ac.cn/Fuping You: fupingyou@hsc.pku.edu.cn
URL: https://www.biorxiv.org/content/10.1101/2020.12.18.423427v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Peking University Health Science Center, Beijing, China
Keywords: SARS-CoV-2, TLR4, trimeric spike protein binding, primates
Summary of Study: The spike protein of SARS-CoV-2 functions as a potent stimulus causing TLR4 activation and sepsis related abnormal responses.
References: doi: https://doi.org/10.1101/2020.12.18.423427
Contact Info: Xiangxi Wang: xiangxi@idp.ac.cn/Fuping You: fupingyou@hsc.pku.edu.cn
URL: https://www.biorxiv.org/content/10.1101/2020.12.18.423427v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Duke Human Vaccine Institute
Keywords: SARS-CoV-2, multimeric receptor binding domain nanoparticle, cross-neutralizing antibody, virus variants, primates
Summary of Study: This study demonstrates the ability of a SARS-CoV-2 RBD 24-mer subunit nanoparticle vaccine to elicit potent cross-neutralizing antibodies against SARS-CoV-1, SARS-CoV-2, SARS-CoV-2 variant B.1.1.7. as well as SARS-related bat betaCoVs.
References: PMID: 33619494 / doi: 10.1101/2021.02.17.431492
Contact Info: Kevin Saunders: kevin.saunders@duke.edu
URL: https://www.biorxiv.org/content/10.1101/2021.02.17.431492v1
NHP Species: multiple species
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Duke Human Vaccine Institute
Keywords: SARS-CoV-2, multimeric receptor binding domain nanoparticle, cross-neutralizing antibody, virus variants, primates
Summary of Study: This study demonstrates the ability of a SARS-CoV-2 RBD 24-mer subunit nanoparticle vaccine to elicit potent cross-neutralizing antibodies against SARS-CoV-1, SARS-CoV-2, SARS-CoV-2 variant B.1.1.7. as well as SARS-related bat betaCoVs.
References: PMID: 33619494 / doi: 10.1101/2021.02.17.431492
Contact Info: Kevin Saunders: kevin.saunders@duke.edu
URL: https://www.biorxiv.org/content/10.1101/2021.02.17.431492v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: BGI-Shenzhen; University of Chinese Academy of Sciences; Guangzhou Institutes of Biomedicine and Health; University of Copenhagen, Huazhen Biosciences, Kunming University of Science and Technology; University of Cambridge, and others.
Keywords: SARS-CoV-2, transcriptome, virus entry, immune response, primates
Summary of Study: The transcriptome of nine organs at single-cell resolution was profiled in monkeys.
References: doi: 10.1101/2020.04.10.022103
Contact Info: Xun Xu: xuxun@genomics.cn; Yong Hou: houyong@genomics.cn; Miguel Estaban: miguel@gibh.ac.cn
URL: https://www.biorxiv.org/content/10.1101/2020.04.10.022103v2
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: BGI-Shenzhen; University of Chinese Academy of Sciences; Guangzhou Institutes of Biomedicine and Health; University of Copenhagen, Huazhen Biosciences, Kunming University of Science and Technology; University of Cambridge, and others.
Keywords: SARS-CoV-2, transcriptome, virus entry, immune response, primates
Summary of Study: The transcriptome of nine organs at single-cell resolution was profiled in monkeys.
References: doi: 10.1101/2020.04.10.022103
Contact Info: Xun Xu: xuxun@genomics.cn; Yong Hou: houyong@genomics.cn; Miguel Estaban: miguel@gibh.ac.cn
URL: https://www.biorxiv.org/content/10.1101/2020.04.10.022103v2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: National Cancer Institute/NIH; BIOQUAL; University of Athens; University of Washington
Keywords: SARS-CoV-2, DNA-based vaccine, immune response, primates
Summary of Study: A vaccine regimen comprising simultaneous co-immunization of DNA and Protein at the same anatomical site showed best neutralizing abilities and was more effective than DNA alone in inducing protective immune responses and controlling SARS-CoV-2 infection.
References: doi: 10.1101/2021.06.11.448032
Contact Info: Barbara Felber: barbara.felber@nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.06.11.448032v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: National Cancer Institute/NIH; BIOQUAL; University of Athens; University of Washington
Keywords: SARS-CoV-2, DNA-based vaccine, immune response, primates
Summary of Study: A vaccine regimen comprising simultaneous co-immunization of DNA and Protein at the same anatomical site showed best neutralizing abilities and was more effective than DNA alone in inducing protective immune responses and controlling SARS-CoV-2 infection.
References: doi: 10.1101/2021.06.11.448032
Contact Info: Barbara Felber: barbara.felber@nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.06.11.448032v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: CAS Key Laboratory of Infection and Immunity, Beijing, China
Keywords: SARS-CoV-2, therapeutics, human monoclonal antibody, primates
Summary of Study: The authors identify and characterize a potent human monoclonal antibody, HB27, that blocks SARS-CoV-2 attachment to its cellular receptor at sub-nM concentrations. Rhesus macaques showed no obvious adverse events when they received a 10-fold effective dose. These results suggest that HB27 is a promising candidate for COVID-19 immuno-therapies.
References: doi:Â https://doi.org/10.1101/2020.11.24.393629
Contact Info: Xiangxi Wang: xiangxi@idp.ac.cn; Cheng-Feng Qin: qincf@bmi.ac.cn
URL: https://www.biorxiv.org/content/10.1101/2020.11.24.393629v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: CAS Key Laboratory of Infection and Immunity, Beijing, China
Keywords: SARS-CoV-2, therapeutics, human monoclonal antibody, primates
Summary of Study: The authors identify and characterize a potent human monoclonal antibody, HB27, that blocks SARS-CoV-2 attachment to its cellular receptor at sub-nM concentrations. Rhesus macaques showed no obvious adverse events when they received a 10-fold effective dose. These results suggest that HB27 is a promising candidate for COVID-19 immuno-therapies.
References: doi:Â https://doi.org/10.1101/2020.11.24.393629
Contact Info: Xiangxi Wang: xiangxi@idp.ac.cn; Cheng-Feng Qin: qincf@bmi.ac.cn
URL: https://www.biorxiv.org/content/10.1101/2020.11.24.393629v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: Duke University, UNC Chapel Hill, NIAID, Ragon Inst.
Keywords: SARS-CoV-2, neutralizing antibodies, cryo-electron microscopy, binding, inflammation, primates
Summary of Study: SARS-CoV-2 RBD and NTD antibodies can increase infection in vitro, but either protect or do not increase coronavirus replication in mouse and monkey models in vivo.
References: PMID: 33442694 / doi: 10.1101/2020.12.31.424729
Contact Info: Kevin Saunders: kevin.saunders@duke.edu
URL: https://www.biorxiv.org/content/10.1101/2020.12.31.424729v2
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: Duke University, UNC Chapel Hill, NIAID, Ragon Inst.
Keywords: SARS-CoV-2, neutralizing antibodies, cryo-electron microscopy, binding, inflammation, primates
Summary of Study: SARS-CoV-2 RBD and NTD antibodies can increase infection in vitro, but either protect or do not increase coronavirus replication in mouse and monkey models in vivo.
References: PMID: 33442694 / doi: 10.1101/2020.12.31.424729
Contact Info: Kevin Saunders: kevin.saunders@duke.edu
URL: https://www.biorxiv.org/content/10.1101/2020.12.31.424729v2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: ImmunityBio, NantK west, Inc., IosBio
Keywords: SARS-CoV-2, hAd5 S-Fusion + N-ETSD vaccine, efficacy, primates
Summary of Study: NHP immunized with the hAd5 S-Fusion + N-ETSD vaccine generated anti-S IgG and showed inhibition in cPass and thus the presence of anti-S RBD neutralizing antibodies (nAbs).
References: doi: 10.1101/2020.12.08.416297
Contact Info: Patrick Soon-Shiong: patrick@nantworks.com
URL: https://www.biorxiv.org/content/10.1101/2020.12.08.416297v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: ImmunityBio, NantK west, Inc., IosBio
Keywords: SARS-CoV-2, hAd5 S-Fusion + N-ETSD vaccine, efficacy, primates
Summary of Study: NHP immunized with the hAd5 S-Fusion + N-ETSD vaccine generated anti-S IgG and showed inhibition in cPass and thus the presence of anti-S RBD neutralizing antibodies (nAbs).
References: doi: 10.1101/2020.12.08.416297
Contact Info: Patrick Soon-Shiong: patrick@nantworks.com
URL: https://www.biorxiv.org/content/10.1101/2020.12.08.416297v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Intuitive Biosciences
Keywords: SARS-CoV-2, spike binding antibodies with neutralizing activity, immunization, primates
Summary of Study: Efficacy of vaccine candidates based on the SARS-CoV-2 spike was assessed in cynomolgus macaques by examinating their ability to generate spike binding antibodies with neutralizing activity. Neutralizing activity persisted for more than 20 weeks. These data support the utility of spike subunit-based antigens as a vaccine for use in humans.
References: PMID: 33398285/doi: 10.1101/2020.12.20.422693
Contact Info: Kimberly Luke (no contact information)
URL: https://www.biorxiv.org/content/10.1101/2020.12.20.422693v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Intuitive Biosciences
Keywords: SARS-CoV-2, spike binding antibodies with neutralizing activity, immunization, primates
Summary of Study: Efficacy of vaccine candidates based on the SARS-CoV-2 spike was assessed in cynomolgus macaques by examinating their ability to generate spike binding antibodies with neutralizing activity. Neutralizing activity persisted for more than 20 weeks. These data support the utility of spike subunit-based antigens as a vaccine for use in humans.
References: PMID: 33398285/doi: 10.1101/2020.12.20.422693
Contact Info: Kimberly Luke (no contact information)
URL: https://www.biorxiv.org/content/10.1101/2020.12.20.422693v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID, Emory, OLAW,
Keywords: SARS-CoV-2, parainfluenza virus-vectored vaccine, pediatric, immune response, primates
Summary of Study: Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine candidate is protective in macaques
References: PMID: 35665011 PMCID: PMC9164439 DOI: 10.1101/2022.05.21.492923
Contact Info: Ursula J. Buchholz: ubuchholz@niaid.nih.gov
URL: https://www.biorxiv.org/content/10.1101/2022.05.21.492923v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID, Emory, OLAW,
Keywords: SARS-CoV-2, parainfluenza virus-vectored vaccine, pediatric, immune response, primates
Summary of Study: Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine candidate is protective in macaques
References: PMID: 35665011 PMCID: PMC9164439 DOI: 10.1101/2022.05.21.492923
Contact Info: Ursula J. Buchholz: ubuchholz@niaid.nih.gov
URL: https://www.biorxiv.org/content/10.1101/2022.05.21.492923v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published:
Study Type/Review:
NPRC/Institute: Tsinghua University; Chongqing Medical University; Chinese Academy of Sciences; Shenzhen Bay Laboratory; Peking University Shenzhen Graduate School, Fudan University
Keywords: SARS-CoV-2, virus variants, entry efficiency, host tropism, sensitivity to neutralizing antibodies, primates
Summary of Study: Results demonstrated that the spike protein of Kappa, Delta or B.1.618 with distinct mutations have altered their ability in utilizing ACE2 orthologs for cell entry.
References: doi: 10.1101/2021.09.03.458829
Contact Info: Qiang Ding: qding@tsinghua.edu.cn
URL: https://www.biorxiv.org/content/10.1101/2021.09.03.458829v1
NHP Species: marmosets
Year Published:
Study Type/Review:
NPRC/Institute: Tsinghua University; Chongqing Medical University; Chinese Academy of Sciences; Shenzhen Bay Laboratory; Peking University Shenzhen Graduate School, Fudan University
Keywords: SARS-CoV-2, virus variants, entry efficiency, host tropism, sensitivity to neutralizing antibodies, primates
Summary of Study: Results demonstrated that the spike protein of Kappa, Delta or B.1.618 with distinct mutations have altered their ability in utilizing ACE2 orthologs for cell entry.
References: doi: 10.1101/2021.09.03.458829
Contact Info: Qiang Ding: qding@tsinghua.edu.cn
URL: https://www.biorxiv.org/content/10.1101/2021.09.03.458829v1