Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID; CureVac AG
Keywords: SARS-CoV-2, mRNA vaccine, immune response, primates
Summary of Study: Prime-boost vaccination with 4 ug of vaccine candidate CV07050101 resulted in limited immune responses in 4 out of 6 non-human primates.
References: doi: 10.1101/2021.07.07.451505
Contact Info: Vincent Munster: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.07.07.451505v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID; CureVac AG
Keywords: SARS-CoV-2, mRNA vaccine, immune response, primates
Summary of Study: Prime-boost vaccination with 4 ug of vaccine candidate CV07050101 resulted in limited immune responses in 4 out of 6 non-human primates.
References: doi: 10.1101/2021.07.07.451505
Contact Info: Vincent Munster: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.07.07.451505v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: SWNPRC/BioNtech
Keywords: SARS-CoV-2, RNA vaccine, immune response, mice, primates
Summary of Study: This study challenged immunization with the BNT162b2 vaccine candidate containing mRNA encoding for the spike glycoprotein in mice and monkeys. Immunization in mice induced a strong immune response and immunization in monkeys fully protected the animal's lungs from SARS-CoV-2 infection.
References: doi: 10.1101/2020.09.08.280818
Contact Info: Ugur Sahin; Email: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.09.08.280818v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: SWNPRC/BioNtech
Keywords: SARS-CoV-2, RNA vaccine, immune response, mice, primates
Summary of Study: This study challenged immunization with the BNT162b2 vaccine candidate containing mRNA encoding for the spike glycoprotein in mice and monkeys. Immunization in mice induced a strong immune response and immunization in monkeys fully protected the animal's lungs from SARS-CoV-2 infection.
References: doi: 10.1101/2020.09.08.280818
Contact Info: Ugur Sahin; Email: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.09.08.280818v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: CNPRC/Vitalant
Keywords: SARS-CoV-2, protective immunity, CD4 helper cells, primates
Summary of Study: vaccine promoting Th1-type Tfh responses that target the S protein may lead to protective immunity
References: doi: 10.1101/2020.07.07.191007
Contact Info: Sonny Elizaldi, UC Davis CIID
URL: https://www.biorxiv.org/content/10.1101/2020.07.07.191007v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: CNPRC/Vitalant
Keywords: SARS-CoV-2, protective immunity, CD4 helper cells, primates
Summary of Study: vaccine promoting Th1-type Tfh responses that target the S protein may lead to protective immunity
References: doi: 10.1101/2020.07.07.191007
Contact Info: Sonny Elizaldi, UC Davis CIID
URL: https://www.biorxiv.org/content/10.1101/2020.07.07.191007v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Sanofi Pasteur
Keywords: SARS-CoV-2, mRNA vaccine candidates, primates
Summary of Study: Several mRNA constructs expressing various structural conformations of S-protein were tested in cynomolgus macaques for their capacity to elicit neutralizing antibodies. The candidate MRT5500 was shown to be immunogenic by eliciting potent neutralizing antibodies in both mice and cynomolgus macaques and is position for further development in clinical studies as a vaccine for the prevention of COVID-19.
References: doi: https://doi.org/10.1101/2020.10.14.337535
Contact Info: none listed
URL: https://www.biorxiv.org/content/10.1101/2020.10.14.337535v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Sanofi Pasteur
Keywords: SARS-CoV-2, mRNA vaccine candidates, primates
Summary of Study: Several mRNA constructs expressing various structural conformations of S-protein were tested in cynomolgus macaques for their capacity to elicit neutralizing antibodies. The candidate MRT5500 was shown to be immunogenic by eliciting potent neutralizing antibodies in both mice and cynomolgus macaques and is position for further development in clinical studies as a vaccine for the prevention of COVID-19.
References: doi: https://doi.org/10.1101/2020.10.14.337535
Contact Info: none listed
URL: https://www.biorxiv.org/content/10.1101/2020.10.14.337535v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Tulane NPRC
Keywords: SARS-CoV-2, immune response, primates
Summary of Study: Increased levels of monocytes and chemokines after infection is associated with viral load and disease severity
References: doi: https://doi.org/10.1101/2020.07.21.213777
Contact Info: Monica Vaccari, [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.07.21.213777v1%20
NHP Species: african green monkeys, rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Tulane NPRC
Keywords: SARS-CoV-2, immune response, primates
Summary of Study: Increased levels of monocytes and chemokines after infection is associated with viral load and disease severity
References: doi: https://doi.org/10.1101/2020.07.21.213777
Contact Info: Monica Vaccari, [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.07.21.213777v1%20
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: ONPRC/YNPRC
Keywords: SARS-CoV-2, kinase inhibitor, primates
Summary of Study: Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques
References: doi: https://doi.org/10.1101/2020.09.16.300277
Contact Info: Dr. Mirko Paiardini; E-mail address: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.09.16.300277v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: ONPRC/YNPRC
Keywords: SARS-CoV-2, kinase inhibitor, primates
Summary of Study: Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques
References: doi: https://doi.org/10.1101/2020.09.16.300277
Contact Info: Dr. Mirko Paiardini; E-mail address: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.09.16.300277v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: NIAID/NIH
Keywords: SARS-CoV-2, virus variants, pathogenicity, immune response, primates
Summary of Study: A side-by-side comparison of three SARS-CoV-2 variants suggests that ongoing circulation under diverse evolutionary pressures favors transmissibility and immune evasion rather than an increase in intrinsic pathogenicity.
References: PMID: 34382034 / doi: 10.1101/2021.05.07.443115
Contact Info: Emmie de Wit: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.05.07.443115v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: NIAID/NIH
Keywords: SARS-CoV-2, virus variants, pathogenicity, immune response, primates
Summary of Study: A side-by-side comparison of three SARS-CoV-2 variants suggests that ongoing circulation under diverse evolutionary pressures favors transmissibility and immune evasion rather than an increase in intrinsic pathogenicity.
References: PMID: 34382034 / doi: 10.1101/2021.05.07.443115
Contact Info: Emmie de Wit: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.05.07.443115v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: University of Liverpool; NIHR Health Protection Unit in Emerging and Zoonotic Infections; University of Bristol; IK Health Security Agency; Mahidol University; Alder Hey Children's Hospital; Imperial College London; The Roslin Institute, University of Edinburgh; Royal United Hospitals Bath NHS Foundation Trust; University of Oxford; A*STAR, Singapore.
Keywords: SARS-CoV-2, viral genomic variants, variant prediction, primates
Summary of Study: The selection pressure at two positions (the P323L and the D614G substitutions in the in NSP12 and the spike protein, respectively) was evaluated in two non-human primate models. The data in this study indicates that in some cases it may be possible to predict the emergence of a new dominant viral genome sequence and hence a new variant.
References: doi: 10.1101/2021.12.23.474030
Contact Info: Julian Hiscox: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.12.23.474030v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: University of Liverpool; NIHR Health Protection Unit in Emerging and Zoonotic Infections; University of Bristol; IK Health Security Agency; Mahidol University; Alder Hey Children's Hospital; Imperial College London; The Roslin Institute, University of Edinburgh; Royal United Hospitals Bath NHS Foundation Trust; University of Oxford; A*STAR, Singapore.
Keywords: SARS-CoV-2, viral genomic variants, variant prediction, primates
Summary of Study: The selection pressure at two positions (the P323L and the D614G substitutions in the in NSP12 and the spike protein, respectively) was evaluated in two non-human primate models. The data in this study indicates that in some cases it may be possible to predict the emergence of a new dominant viral genome sequence and hence a new variant.
References: doi: 10.1101/2021.12.23.474030
Contact Info: Julian Hiscox: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.12.23.474030v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: NIAID; La Jolla Institute for Immunology; University of California; University of Capetown
Keywords: SARS-CoV-2, viral replication, pathogenesis. Immune response, primates
Summary of Study: SARS-CoV-2 infection leads to mild, focal lung inflammation, and type 1 IFN activated myeloid cells that mostly resolve prior to the influx of virus-specific effector T cells or antibody responses in rhesus macaques.
References: doi: 10.1101/2022.01.06.475282
Contact Info: Daniel Barber: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.01.06.475282v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: NIAID; La Jolla Institute for Immunology; University of California; University of Capetown
Keywords: SARS-CoV-2, viral replication, pathogenesis. Immune response, primates
Summary of Study: SARS-CoV-2 infection leads to mild, focal lung inflammation, and type 1 IFN activated myeloid cells that mostly resolve prior to the influx of virus-specific effector T cells or antibody responses in rhesus macaques.
References: doi: 10.1101/2022.01.06.475282
Contact Info: Daniel Barber: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.01.06.475282v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: SUNY Upstate Medical University; Walter Reed Army Institute of Research; NIAID; Henry M. Jackson Foundation for the Advancement of Military Medicine
Keywords: SARS-CoV-2, mRNA-1273 vaccine, single-cell transcriptomic profiling, virus variants, inflammation, primates
Summary of Study: Single cell RNA sequencing analysis demonstrates that mRNA-1273 vaccination limits the development of lower respiratory tract inflammation in SARS-CoV-2 challenged rhesus macaques.
References: doi: 10.1101/2021.12.24.474132
Contact Info: Robert Seder: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.12.24.474132v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: SUNY Upstate Medical University; Walter Reed Army Institute of Research; NIAID; Henry M. Jackson Foundation for the Advancement of Military Medicine
Keywords: SARS-CoV-2, mRNA-1273 vaccine, single-cell transcriptomic profiling, virus variants, inflammation, primates
Summary of Study: Single cell RNA sequencing analysis demonstrates that mRNA-1273 vaccination limits the development of lower respiratory tract inflammation in SARS-CoV-2 challenged rhesus macaques.
References: doi: 10.1101/2021.12.24.474132
Contact Info: Robert Seder: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.12.24.474132v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Duke University School of Medicine; University of North Carolina at Chapel Hill; NIAID; Division of Viral Products, FDA; Beth Israel Deaconess Medical Center; University of Pennsylvania; Corporate Research Materials Lab, 3M Company; Infectious Disease Research Institute; BIOQUAL
Keywords: SARS-CoV-2, ferritin nanoparticle (RBD-scNP) vaccine, virus variants, immune response, primates
Summary of Study: Study demonstrates that scNP vaccines with SARS-CoV-2 spike or spike subunits confer potent protection in NHPs against WA-1, Beta and Delta variants, and that they induce neutralizing antibodies to all SARS-CoV-2 variants tested in vitro.
References: doi: 10.1101/2022.01.26.477915
Contact Info: Kevin Saunders: [email protected]; Barton Haynes: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.01.26.477915v2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Duke University School of Medicine; University of North Carolina at Chapel Hill; NIAID; Division of Viral Products, FDA; Beth Israel Deaconess Medical Center; University of Pennsylvania; Corporate Research Materials Lab, 3M Company; Infectious Disease Research Institute; BIOQUAL
Keywords: SARS-CoV-2, ferritin nanoparticle (RBD-scNP) vaccine, virus variants, immune response, primates
Summary of Study: Study demonstrates that scNP vaccines with SARS-CoV-2 spike or spike subunits confer potent protection in NHPs against WA-1, Beta and Delta variants, and that they induce neutralizing antibodies to all SARS-CoV-2 variants tested in vitro.
References: doi: 10.1101/2022.01.26.477915
Contact Info: Kevin Saunders: [email protected]; Barton Haynes: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.01.26.477915v2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Northwestern University Feinberg School of Medicine; Tulane National Primate Research Center; New Iberia Research Center
Keywords: SARS-CoV-2, male genital tract, positron emission tomography, pathogenesis, primates
Summary of Study: Results suggest that SARS-CoV-2 rapidly and efficiently infects multiple tissues of the male genital tract (MGT) early during infection in rhesus macaques.
References: PMID: 35262081 / doi: 10.1101/2022.02.25.481974
Contact Info: Thomas J. Hope: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.02.25.481974v2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Northwestern University Feinberg School of Medicine; Tulane National Primate Research Center; New Iberia Research Center
Keywords: SARS-CoV-2, male genital tract, positron emission tomography, pathogenesis, primates
Summary of Study: Results suggest that SARS-CoV-2 rapidly and efficiently infects multiple tissues of the male genital tract (MGT) early during infection in rhesus macaques.
References: PMID: 35262081 / doi: 10.1101/2022.02.25.481974
Contact Info: Thomas J. Hope: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.02.25.481974v2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: California Institute of Technology; NIAID, Fred Hutchinson Cancer Research Center; Bioqual; University of Oxford; Howard Hughes Medical Institute
Keywords: SARS-CoV-2, spike receptor-binding domains, mosaic nanoparticles, immunogenicity, mice, primates
Summary of Study: A mosaic RBD nanoparticle presenting 8 different sarbecovirus RBDs protected against challenges from both matched and mismatched sarbecoviruses, as compared with homotypic SARS-2 RBD nanoparticles that protected fully only against a matched challenge.
References: PMID: 35378752 / doi: 10.1101/2022.03.25.485875
Contact Info: Pamela Bjorkman: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.03.25.485875v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: California Institute of Technology; NIAID, Fred Hutchinson Cancer Research Center; Bioqual; University of Oxford; Howard Hughes Medical Institute
Keywords: SARS-CoV-2, spike receptor-binding domains, mosaic nanoparticles, immunogenicity, mice, primates
Summary of Study: A mosaic RBD nanoparticle presenting 8 different sarbecovirus RBDs protected against challenges from both matched and mismatched sarbecoviruses, as compared with homotypic SARS-2 RBD nanoparticles that protected fully only against a matched challenge.
References: PMID: 35378752 / doi: 10.1101/2022.03.25.485875
Contact Info: Pamela Bjorkman: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.03.25.485875v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID, Emory, OLAW,
Keywords: SARS-CoV-2, parainfluenza virus-vectored vaccine, pediatric, immune response, primates
Summary of Study: Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine candidate is protective in macaques
References: PMID: 35665011 PMCID: PMC9164439 DOI: 10.1101/2022.05.21.492923
Contact Info: Ursula J. Buchholz: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.05.21.492923v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID, Emory, OLAW,
Keywords: SARS-CoV-2, parainfluenza virus-vectored vaccine, pediatric, immune response, primates
Summary of Study: Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine candidate is protective in macaques
References: PMID: 35665011 PMCID: PMC9164439 DOI: 10.1101/2022.05.21.492923
Contact Info: Ursula J. Buchholz: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.05.21.492923v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: National Institute of Allergy and Infectious Diseases, National Institutes of Health
Keywords: SARS-CoV-2, virus variants, pathology, immune response, primates
Summary of Study: Disease severity among variants is unequal, with a lower viral load and thus reduced clinical disease in Omicron versus Delta variants.
References: PMID: 35971544 / doi: 10.1101/2022.08.01.502390
Contact Info: Neeltje van Doremalen: [email protected]; Kyle Rosenke: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.08.01.502390v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: National Institute of Allergy and Infectious Diseases, National Institutes of Health
Keywords: SARS-CoV-2, virus variants, pathology, immune response, primates
Summary of Study: Disease severity among variants is unequal, with a lower viral load and thus reduced clinical disease in Omicron versus Delta variants.
References: PMID: 35971544 / doi: 10.1101/2022.08.01.502390
Contact Info: Neeltje van Doremalen: [email protected]; Kyle Rosenke: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.08.01.502390v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: National Institute of Allergy and
Infectious Diseases, National Institutes of Health; Washington National Primate Research Center, University of Washington; HDT Bio; Fred Hutchinson Cancer Research Center
Keywords: SARS-CoV-2, replicon RNA vaccine, neutralizing antibody response, pathology, primates
Summary of Study: A self-amplifying replicon RNA vaccine elicits protective immunity to COVID-19 and a strong protective response even after antibody levels decreased to undetectable levels.
References: PMID: 35982677 / doi: 10.1101/2022.08.08.503239
Contact Info: Deborah Heydenburg Fuller; Jesse H. Erasmus
URL: https://www.biorxiv.org/content/10.1101/2022.08.08.503239v1
NHP Species: pigtail macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: National Institute of Allergy and
Infectious Diseases, National Institutes of Health; Washington National Primate Research Center, University of Washington; HDT Bio; Fred Hutchinson Cancer Research Center
Keywords: SARS-CoV-2, replicon RNA vaccine, neutralizing antibody response, pathology, primates
Summary of Study: A self-amplifying replicon RNA vaccine elicits protective immunity to COVID-19 and a strong protective response even after antibody levels decreased to undetectable levels.
References: PMID: 35982677 / doi: 10.1101/2022.08.08.503239
Contact Info: Deborah Heydenburg Fuller; Jesse H. Erasmus
URL: https://www.biorxiv.org/content/10.1101/2022.08.08.503239v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Sarafan ChEM-H, Stanford University, Stanford, CA; Department of Chemistry, Stanford University, Stanford, CA; Department of Biochemistry, School of Medicine, Stanford University, Stanford, CA; others
Keywords: SARS-CoV-2, ferritin-based, protein-nanoparticle vaccine, immune response, booster, primates
Summary of Study: A ferritin-based COVID-19 nanoparticle vaccine
References: doi: 10.1101/2022.12.25.521784
Contact Info: Peter S Kim: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.12.25.521784v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Sarafan ChEM-H, Stanford University, Stanford, CA; Department of Chemistry, Stanford University, Stanford, CA; Department of Biochemistry, School of Medicine, Stanford University, Stanford, CA; others
Keywords: SARS-CoV-2, ferritin-based, protein-nanoparticle vaccine, immune response, booster, primates
Summary of Study: A ferritin-based COVID-19 nanoparticle vaccine
References: doi: 10.1101/2022.12.25.521784
Contact Info: Peter S Kim: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.12.25.521784v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: NIAID, NHLBI, Emory NPRC, Bioqual, Inc.
Keywords: SARS-CoV-2, inflammation, clonal hematopoiesis, respiratory tract, primates
Summary of Study: Findings suggest potential pathophysiological differences with or without clonal hematopoiesis upon SARS-CoV-2 infection
References: doi: 10.1101/2023.01.01.522064
Contact Info: Tae-Hoon Shin: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.01.01.522064v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: NIAID, NHLBI, Emory NPRC, Bioqual, Inc.
Keywords: SARS-CoV-2, inflammation, clonal hematopoiesis, respiratory tract, primates
Summary of Study: Findings suggest potential pathophysiological differences with or without clonal hematopoiesis upon SARS-CoV-2 infection
References: doi: 10.1101/2023.01.01.522064
Contact Info: Tae-Hoon Shin: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.01.01.522064v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: BGI-Shenzhen; University of Chinese Academy of Sciences; Guangzhou Institutes of Biomedicine and Health; University of Copenhagen, Huazhen Biosciences, Kunming University of Science and Technology; University of Cambridge, and others.
Keywords: SARS-CoV-2, transcriptome, virus entry, immune response, primates
Summary of Study: The transcriptome of nine organs at single-cell resolution was profiled in monkeys.
References: doi: 10.1101/2020.04.10.022103
Contact Info: Xun Xu: [email protected]; Yong Hou: [email protected]; Miguel Estaban: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.04.10.022103v2
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: BGI-Shenzhen; University of Chinese Academy of Sciences; Guangzhou Institutes of Biomedicine and Health; University of Copenhagen, Huazhen Biosciences, Kunming University of Science and Technology; University of Cambridge, and others.
Keywords: SARS-CoV-2, transcriptome, virus entry, immune response, primates
Summary of Study: The transcriptome of nine organs at single-cell resolution was profiled in monkeys.
References: doi: 10.1101/2020.04.10.022103
Contact Info: Xun Xu: [email protected]; Yong Hou: [email protected]; Miguel Estaban: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.04.10.022103v2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: California National Primate Research Center; University of California, Davis; Vitalant Research Institute; University of California, Irvine School of Medicine; DMID/NIAID/NIH; University of California, San Francisco
Keywords: SARS-CoV-2, convalescent plasma, immune response, pathology, primates
Summary of Study: While administration of CCP did not result in a detectable reduction in virus replication in the respiratory tract, it significantly reduced lung inflammation in macaques infected with SARS-CoV-2.
References: PMID: 34494025 / doi: 10.1101/2021.09.01.458520
Contact Info: Koen Van Rompay: [email protected]; Rachel Reader: [email protected]; Michael Busch: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.09.01.458520v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: California National Primate Research Center; University of California, Davis; Vitalant Research Institute; University of California, Irvine School of Medicine; DMID/NIAID/NIH; University of California, San Francisco
Keywords: SARS-CoV-2, convalescent plasma, immune response, pathology, primates
Summary of Study: While administration of CCP did not result in a detectable reduction in virus replication in the respiratory tract, it significantly reduced lung inflammation in macaques infected with SARS-CoV-2.
References: PMID: 34494025 / doi: 10.1101/2021.09.01.458520
Contact Info: Koen Van Rompay: [email protected]; Rachel Reader: [email protected]; Michael Busch: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.09.01.458520v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Shanghai Jiao Tong University; Westlake University, China; University of Texas, medical Branch; Jecho Biopharmaceuticals Co.; China CDC; Zhengzhou University People's Hospital; Jecho Laboratories (Frederick, MD)
Keywords: SARS-CoV-2, monoclonal antibody, virus genomic variants, spike protein, mice, primates
Summary of Study: This report characterizes the therapeutic antibodies specific to the tip of spike against SARS-CoV-2 and suggests the potential of antibody treatment with 2G1 to bring clinical benefit to COVID-19 patients.
References: doi: 10.1101/2021.09.24.461616
Contact Info: Lei Han: [email protected]; Hua Jiang: [email protected]; Yueqing Xie: jecholabs.com; Qiang Zhou: [email protected]; Jianwei Zhu: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.09.24.461616v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Shanghai Jiao Tong University; Westlake University, China; University of Texas, medical Branch; Jecho Biopharmaceuticals Co.; China CDC; Zhengzhou University People's Hospital; Jecho Laboratories (Frederick, MD)
Keywords: SARS-CoV-2, monoclonal antibody, virus genomic variants, spike protein, mice, primates
Summary of Study: This report characterizes the therapeutic antibodies specific to the tip of spike against SARS-CoV-2 and suggests the potential of antibody treatment with 2G1 to bring clinical benefit to COVID-19 patients.
References: doi: 10.1101/2021.09.24.461616
Contact Info: Lei Han: [email protected]; Hua Jiang: [email protected]; Yueqing Xie: jecholabs.com; Qiang Zhou: [email protected]; Jianwei Zhu: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.09.24.461616v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Duke University Medical Center, UNC- Chapel Hill, Louisiana State Univ., Infectious Disease Institute (Seattle, WA), Moderna, NIAID, California National Primate Research Center, Cornell Weill Medical College
Keywords: SARS-CoV-2, mRNA vaccine, nanoparticles, immune response, primates
Summary of Study: SARS-CoV-2 vaccines are well-tolerated and highly immunogenic in infant rhesus macaques.
References: PMID: 33851156 / doi: 10.1101/2021.04.05.438479
Contact Info: Kristina De Paris: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.04.05.438479v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Duke University Medical Center, UNC- Chapel Hill, Louisiana State Univ., Infectious Disease Institute (Seattle, WA), Moderna, NIAID, California National Primate Research Center, Cornell Weill Medical College
Keywords: SARS-CoV-2, mRNA vaccine, nanoparticles, immune response, primates
Summary of Study: SARS-CoV-2 vaccines are well-tolerated and highly immunogenic in infant rhesus macaques.
References: PMID: 33851156 / doi: 10.1101/2021.04.05.438479
Contact Info: Kristina De Paris: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.04.05.438479v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: MIT, Harvard Medical School, Vaccine Analytics and Formulation Center (Univ. of Kansas), Cummings School of Veterinary Medicine (Tufts Univ.), SpyBiotech Ltd., Bioqual, Bill & Melinda Gates Fdtn.
Keywords: SARS-CoV-2, protein subunit vaccine, manufacturing, preclinical testing, primates
Summary of Study: A modular protein subunit vaccine candidate elicits a strong immune response in cynomolgus macaques and protects against SARS-CoV-2 challenge. This vaccine candidate is currently being tested in clinical trials (ANZCTR Registration number ACTRN12620000817943).
References: PMID: 34282417 / doi: 10.1101/2021.07.13.452251
Contact Info: Dan Barouch: [email protected]; J. Christopher Love: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.07.13.452251v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: MIT, Harvard Medical School, Vaccine Analytics and Formulation Center (Univ. of Kansas), Cummings School of Veterinary Medicine (Tufts Univ.), SpyBiotech Ltd., Bioqual, Bill & Melinda Gates Fdtn.
Keywords: SARS-CoV-2, protein subunit vaccine, manufacturing, preclinical testing, primates
Summary of Study: A modular protein subunit vaccine candidate elicits a strong immune response in cynomolgus macaques and protects against SARS-CoV-2 challenge. This vaccine candidate is currently being tested in clinical trials (ANZCTR Registration number ACTRN12620000817943).
References: PMID: 34282417 / doi: 10.1101/2021.07.13.452251
Contact Info: Dan Barouch: [email protected]; J. Christopher Love: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.07.13.452251v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: California National Primate Research Center; School of Medicine, UC Davis; Vitalant Research Institute; University of Colorado School of Medicine; University of California, Irvine; and others.
Keywords: SARS-CoV-2, convalescent plasma, intratracheal and intranasal routes, pathology, primates
Summary of Study: While administration of convalescent plasma (CCP) did not result in a detectable reduction in virus replication in the respiratory tract, it significantly reduced lung inflammation.
References: doi: 10.1101/2021.09.01.458520
Contact Info: Koen Van Rompay: [email protected]; Michael Busch: [email protected]; J. Rachel Reader: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.09.01.458520v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: California National Primate Research Center; School of Medicine, UC Davis; Vitalant Research Institute; University of Colorado School of Medicine; University of California, Irvine; and others.
Keywords: SARS-CoV-2, convalescent plasma, intratracheal and intranasal routes, pathology, primates
Summary of Study: While administration of convalescent plasma (CCP) did not result in a detectable reduction in virus replication in the respiratory tract, it significantly reduced lung inflammation.
References: doi: 10.1101/2021.09.01.458520
Contact Info: Koen Van Rompay: [email protected]; Michael Busch: [email protected]; J. Rachel Reader: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.09.01.458520v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Walter Reed National Military Medical Center; Bioqual; University of Pittsburgh Medical Center; Henry Jackson Foundation; Ragon Institute of MGH, MIT, and Harvard
Keywords: SARS-CoV-2, live oral vaccine, gastrointestinal tract, pathology, immune response, primates
Summary of Study: Post-pyloric inoculation of live SARS-CoV-2 is weakly immunogenic and confers partial protection against respiratory SARS-CoV-2 challenge in rhesus macaques.
References: doi: 10.1128/JVI.01599-21
Contact Info: Dan Barouch: [email protected]
URL: https://journals.asm.org/doi/10.1128/JVI.01599-21?url_ver=Z39.88-2003&rfr_id=or…
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Walter Reed National Military Medical Center; Bioqual; University of Pittsburgh Medical Center; Henry Jackson Foundation; Ragon Institute of MGH, MIT, and Harvard
Keywords: SARS-CoV-2, live oral vaccine, gastrointestinal tract, pathology, immune response, primates
Summary of Study: Post-pyloric inoculation of live SARS-CoV-2 is weakly immunogenic and confers partial protection against respiratory SARS-CoV-2 challenge in rhesus macaques.
References: doi: 10.1128/JVI.01599-21
Contact Info: Dan Barouch: [email protected]
URL: https://journals.asm.org/doi/10.1128/JVI.01599-21?url_ver=Z39.88-2003&rfr_id=or…
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published:
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Florida State University; University of Texas Medical Branch, Perelman School of Medicine; and others.
Keywords: SARS-CoV-2, respiratory viral challenge, immune response, pathology, primates
Summary of Study: SARS-CoV-2 infection of pigtail macaques recapitulates important features of COVID-19 and reveals new immune and viral dynamics and thus may serve as a useful animal model for studying pathogenesis and testing vaccines and therapeutics.
References: doi: 10.1101/2021.08.28.458047
Contact Info: Nicholas Maness: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.08.28.458047v1
NHP Species: pigtail macaques
Year Published:
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Florida State University; University of Texas Medical Branch, Perelman School of Medicine; and others.
Keywords: SARS-CoV-2, respiratory viral challenge, immune response, pathology, primates
Summary of Study: SARS-CoV-2 infection of pigtail macaques recapitulates important features of COVID-19 and reveals new immune and viral dynamics and thus may serve as a useful animal model for studying pathogenesis and testing vaccines and therapeutics.
References: doi: 10.1101/2021.08.28.458047
Contact Info: Nicholas Maness: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.08.28.458047v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Ology Bioservices; Harvard Medical School; Vanderbilt University Medical Center; US Department of Defense; Logistics Management Institute; Washington University School of Medicine
Keywords: SARS-CoV-2, antibody treatment, spike protein, protection, primates
Summary of Study: Passive transfer of two neutralizing antibodies (COV2-2130 and COV2-2381) given prophylactically -- either individually or in combination (combination designated ADM03820) by intravenous or intramuscular route conferred virological protection in a NHP model of SARS-CoV-2 infection, and ADM03820 potently neutralized SARS-CoV-2 variants of concern in vitro.
References: doi: 10.1101/2021.09.27.462074
Contact Info: Dan Barouch: [email protected]; James Crowe: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.09.27.462074v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Ology Bioservices; Harvard Medical School; Vanderbilt University Medical Center; US Department of Defense; Logistics Management Institute; Washington University School of Medicine
Keywords: SARS-CoV-2, antibody treatment, spike protein, protection, primates
Summary of Study: Passive transfer of two neutralizing antibodies (COV2-2130 and COV2-2381) given prophylactically -- either individually or in combination (combination designated ADM03820) by intravenous or intramuscular route conferred virological protection in a NHP model of SARS-CoV-2 infection, and ADM03820 potently neutralized SARS-CoV-2 variants of concern in vitro.
References: doi: 10.1101/2021.09.27.462074
Contact Info: Dan Barouch: [email protected]; James Crowe: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.09.27.462074v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: COVAXX, Inc.; United Biomedical Inc., Asia; United BioPharma; United Biomedical Inc., USA; Academia Sinica; University of Texas Medical Branch; Galveston National Laboratory
Keywords: SARS-CoV-2, multitope protein-peptide vaccine, immunogenicity, protection, mice, rats, Guinea pigs, primates
Summary of Study: With a Phase 1 trial ongoing in Taiwan and additional trials planned worldwide, UB-612 is a highly promising and differentiated vaccine candidate for prevention of SARS-CoV-2 transmission and COVID-19 disease.
References: doi: 10.1101/2020.11.30.399154
Contact Info: Chang Yi Wang: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.11.30.399154v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: COVAXX, Inc.; United Biomedical Inc., Asia; United BioPharma; United Biomedical Inc., USA; Academia Sinica; University of Texas Medical Branch; Galveston National Laboratory
Keywords: SARS-CoV-2, multitope protein-peptide vaccine, immunogenicity, protection, mice, rats, Guinea pigs, primates
Summary of Study: With a Phase 1 trial ongoing in Taiwan and additional trials planned worldwide, UB-612 is a highly promising and differentiated vaccine candidate for prevention of SARS-CoV-2 transmission and COVID-19 disease.
References: doi: 10.1101/2020.11.30.399154
Contact Info: Chang Yi Wang: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.11.30.399154v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Harvard Medical School; Walter Reed National Military Medical Center; Ragon Institute of MGH, MIT and Harvard; Bioqual; University of Pittsburgh; Henry Jackson Foundation
Keywords: SARS-CoV-2, live oral vaccine, immune response, pathology, primates
Summary of Study: Post-pyloric inoculation of live SARS-CoV-2 is weakly immunogenic and confers partial protection against respiratory SARS-CoV-2 challenge in rhesus macaques.
References: doi: 10.1101/2021.09.13.460191
Contact Info: Dan Barouch: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.09.13.460191v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Harvard Medical School; Walter Reed National Military Medical Center; Ragon Institute of MGH, MIT and Harvard; Bioqual; University of Pittsburgh; Henry Jackson Foundation
Keywords: SARS-CoV-2, live oral vaccine, immune response, pathology, primates
Summary of Study: Post-pyloric inoculation of live SARS-CoV-2 is weakly immunogenic and confers partial protection against respiratory SARS-CoV-2 challenge in rhesus macaques.
References: doi: 10.1101/2021.09.13.460191
Contact Info: Dan Barouch: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.09.13.460191v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute, Henry M. Jackson Foundation for the Advancement of Military Medicine, NCI, BIOQUAL, Texas Biomedical Research Institute, Columbia University
Keywords: SARS-CoV-2, ferritin nanoparticle vaccine, immune response, primates
Summary of Study: Evaluation of a SARS-CoV-2 Spike receptor-binding doman ferritin nanoparticle protein vaccine (RFN), adjuvanted with a liposomal-QS21 formulation (ALFQ) elicits humoral and cellular immune responses exceeding those of current vaccines.
References: PMID: 33851155 / doi: 10.1101/2021.04.09.439166
Contact Info: Diane Bolton: [email protected]; Kayvon Modjarrad: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.04.09.439166v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute, Henry M. Jackson Foundation for the Advancement of Military Medicine, NCI, BIOQUAL, Texas Biomedical Research Institute, Columbia University
Keywords: SARS-CoV-2, ferritin nanoparticle vaccine, immune response, primates
Summary of Study: Evaluation of a SARS-CoV-2 Spike receptor-binding doman ferritin nanoparticle protein vaccine (RFN), adjuvanted with a liposomal-QS21 formulation (ALFQ) elicits humoral and cellular immune responses exceeding those of current vaccines.
References: PMID: 33851155 / doi: 10.1101/2021.04.09.439166
Contact Info: Diane Bolton: [email protected]; Kayvon Modjarrad: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.04.09.439166v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Perelman School of Medicine; University of Wisconsin-Madison; The Children's Hospital of Philadelphia; Cardiomyogen; ORRA Group, LLC; Stanford University, and others
Keywords: SARS-CoV-2, AAV vectors, immunization, immune response, mice, primates
Summary of Study: These studies demonstrate not only that AAV6 and AAV9 can function as effective vaccine platforms, but also that vaccine can provide long-term efficacy primarily through the induction of cellular immunity.
References: doi: 10.1101/2021.08.16.456441
Contact Info: Hansell Stedman: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.08.16.456441v1.article-metrics
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Perelman School of Medicine; University of Wisconsin-Madison; The Children's Hospital of Philadelphia; Cardiomyogen; ORRA Group, LLC; Stanford University, and others
Keywords: SARS-CoV-2, AAV vectors, immunization, immune response, mice, primates
Summary of Study: These studies demonstrate not only that AAV6 and AAV9 can function as effective vaccine platforms, but also that vaccine can provide long-term efficacy primarily through the induction of cellular immunity.
References: doi: 10.1101/2021.08.16.456441
Contact Info: Hansell Stedman: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.08.16.456441v1.article-metrics
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published:
Study Type/Review:
NPRC/Institute: Tsinghua University; Chongqing Medical University; Chinese Academy of Sciences; Shenzhen Bay Laboratory; Peking University Shenzhen Graduate School, Fudan University
Keywords: SARS-CoV-2, virus variants, entry efficiency, host tropism, sensitivity to neutralizing antibodies, primates
Summary of Study: Results demonstrated that the spike protein of Kappa, Delta or B.1.618 with distinct mutations have altered their ability in utilizing ACE2 orthologs for cell entry.
References: doi: 10.1101/2021.09.03.458829
Contact Info: Qiang Ding: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.09.03.458829v1
NHP Species: marmosets
Year Published:
Study Type/Review:
NPRC/Institute: Tsinghua University; Chongqing Medical University; Chinese Academy of Sciences; Shenzhen Bay Laboratory; Peking University Shenzhen Graduate School, Fudan University
Keywords: SARS-CoV-2, virus variants, entry efficiency, host tropism, sensitivity to neutralizing antibodies, primates
Summary of Study: Results demonstrated that the spike protein of Kappa, Delta or B.1.618 with distinct mutations have altered their ability in utilizing ACE2 orthologs for cell entry.
References: doi: 10.1101/2021.09.03.458829
Contact Info: Qiang Ding: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.09.03.458829v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Jiangsu Rec-biotechnology Co Ltd, China; Chinese Academy of Medical Sciences; Wuhan University; Jiangsu Provincial Center for Disease Control and Prevention
Keywords: SARS-CoV-2, subunit vaccine, protective immunity, mice, primates
Summary of Study: Two-dose immunizations of ReCOV, a recombinant trimeric NTD and RBD two-component SARS-CoV-2 subunit vaccine adjuvanted with BFA03, provided complete protection against challenge with SARS-CoV-2 in hACE2 transgenic mice and rhesus macaques, without observable antibody-dependent enhancement of infection.
References: doi: 10.1101/2021.11.03.467182
Contact Info: Yong Liu: [email protected]; Feng-Cai Zhu: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.11.03.467182v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Jiangsu Rec-biotechnology Co Ltd, China; Chinese Academy of Medical Sciences; Wuhan University; Jiangsu Provincial Center for Disease Control and Prevention
Keywords: SARS-CoV-2, subunit vaccine, protective immunity, mice, primates
Summary of Study: Two-dose immunizations of ReCOV, a recombinant trimeric NTD and RBD two-component SARS-CoV-2 subunit vaccine adjuvanted with BFA03, provided complete protection against challenge with SARS-CoV-2 in hACE2 transgenic mice and rhesus macaques, without observable antibody-dependent enhancement of infection.
References: doi: 10.1101/2021.11.03.467182
Contact Info: Yong Liu: [email protected]; Feng-Cai Zhu: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.11.03.467182v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: IRSICaixa AIDS Research Institute; Barcelona Institute of Science & Technology; Yerkes National Primate Research Center, Emory University, and more
Keywords: SARS-CoV-2, antigen presenting myeloid cells, pathology, primates
Summary of Study: Although being largely resistant to SARS-CoV-2 infection, myeloid cells effectively capture and trap incoming viruses in internal compartments connected with the plasma membrane, eventually leading to viral degradation over time.
References: doi: 10.1101/2021.05.11.443572
Contact Info: Javier Martinez/Picado: [email protected]; Julia Vergara-Alert: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.05.11.443572v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: IRSICaixa AIDS Research Institute; Barcelona Institute of Science & Technology; Yerkes National Primate Research Center, Emory University, and more
Keywords: SARS-CoV-2, antigen presenting myeloid cells, pathology, primates
Summary of Study: Although being largely resistant to SARS-CoV-2 infection, myeloid cells effectively capture and trap incoming viruses in internal compartments connected with the plasma membrane, eventually leading to viral degradation over time.
References: doi: 10.1101/2021.05.11.443572
Contact Info: Javier Martinez/Picado: [email protected]; Julia Vergara-Alert: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.05.11.443572v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Washington National Primate Research Center; North Carolina State University College of Veterinary Medicine; University of Washington.
Keywords: SARS-CoV-2, single cell immune repertoire profiling, gene expression, primates
Summary of Study: Results establish the ability to perform high throughput scIRS analysis in rhesus macaques with comparable performances to commercially available platforms.
References: doi: 10.1101/2021.08.17.456682
Contact Info: Xinxia Peng: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.08.17.456682v1.supplementary-mater…
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Washington National Primate Research Center; North Carolina State University College of Veterinary Medicine; University of Washington.
Keywords: SARS-CoV-2, single cell immune repertoire profiling, gene expression, primates
Summary of Study: Results establish the ability to perform high throughput scIRS analysis in rhesus macaques with comparable performances to commercially available platforms.
References: doi: 10.1101/2021.08.17.456682
Contact Info: Xinxia Peng: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.08.17.456682v1.supplementary-mater…
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Meissa Vaccines, Inc., BIOQUAL, Inc., University of Texas Medical Branch, Butler University, Vanderbilt University School of Medicine
Keywords: SARS-CoV-2, vaccine candidate, immune response, virus variants, primate
Summary of Study: One mucosal administration of MV-014-212 in African green monkeys protected against SARS-CoV-2 challenge. Intranasally delivered, live attenuated vaccines such as MV-014-212 entail low-cost manufacturing suitable for global deployment. MV-014-212 is currently in Phase I clinical trials as a single-dose intranasal COVID-19 vaccine.
References: doi: 10.1101/2021.07.16.452733
Contact Info: Mariana Tioni: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.07.16.452733v2
NHP Species: african green monkeys
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Meissa Vaccines, Inc., BIOQUAL, Inc., University of Texas Medical Branch, Butler University, Vanderbilt University School of Medicine
Keywords: SARS-CoV-2, vaccine candidate, immune response, virus variants, primate
Summary of Study: One mucosal administration of MV-014-212 in African green monkeys protected against SARS-CoV-2 challenge. Intranasally delivered, live attenuated vaccines such as MV-014-212 entail low-cost manufacturing suitable for global deployment. MV-014-212 is currently in Phase I clinical trials as a single-dose intranasal COVID-19 vaccine.
References: doi: 10.1101/2021.07.16.452733
Contact Info: Mariana Tioni: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.07.16.452733v2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: COVAXX, United Biomedical< Inc., United BioPharma, Academic Sinica, University of Texas Medical Branch, Galveston National Library
Keywords: SARS-CoV-2, multitope protein-peptide vaccine, immune response, toxicity, protection, guinea pigs, rats, primates
Summary of Study: The authors have developed and demonstrated proof of concept for UB-612, a novel multitope protein-peptide vaccine being rapidly advanced in clinical trials for prevention of SARS-CoV-2 infection and COVID-19. Extremely high levels of neutralizing antibodies were shown and Th1 prone immune response was induced by the vaccine that protected animals, challenged by a high dose of SARS-CoV-2, without induction of immunopathology in the lungs.
References: doi: 10.1101/2020.11.30.399154
Contact Info: Chang Yi Wang: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.11.30.399154v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: COVAXX, United Biomedical< Inc., United BioPharma, Academic Sinica, University of Texas Medical Branch, Galveston National Library
Keywords: SARS-CoV-2, multitope protein-peptide vaccine, immune response, toxicity, protection, guinea pigs, rats, primates
Summary of Study: The authors have developed and demonstrated proof of concept for UB-612, a novel multitope protein-peptide vaccine being rapidly advanced in clinical trials for prevention of SARS-CoV-2 infection and COVID-19. Extremely high levels of neutralizing antibodies were shown and Th1 prone immune response was induced by the vaccine that protected animals, challenged by a high dose of SARS-CoV-2, without induction of immunopathology in the lungs.
References: doi: 10.1101/2020.11.30.399154
Contact Info: Chang Yi Wang: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.11.30.399154v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published:
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Zalgen Labs, LLC., Duke University Medical Center
Keywords: SARS-CoV-2, route of experimental infection, immune response, pathology, primates
Summary of Study: Lack of regenerative activity in the lung was present in both species post-resolution of most of the viral RNA, indicating the NHP model of SARS-CoV-2 infection can be utilized during anti-fibrosis therapeutic development and evaluation and has potential utility in evaluation of post-acute COVID sequelae.
References: doi: 10.1101/2021.11.28.470250
Contact Info: Chad Roy: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.11.28.470250v1
NHP Species: rhesus macaques, african green monkeys
Year Published:
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Zalgen Labs, LLC., Duke University Medical Center
Keywords: SARS-CoV-2, route of experimental infection, immune response, pathology, primates
Summary of Study: Lack of regenerative activity in the lung was present in both species post-resolution of most of the viral RNA, indicating the NHP model of SARS-CoV-2 infection can be utilized during anti-fibrosis therapeutic development and evaluation and has potential utility in evaluation of post-acute COVID sequelae.
References: doi: 10.1101/2021.11.28.470250
Contact Info: Chad Roy: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.11.28.470250v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Fred Hutchinson Cancer Research Center; University of Washington; Washington National Primate Research Center; HDT Bio; NIAID
Keywords: SARS-CoV-2, phage-based deep mutational scanning approach, spike protein, immune response, primates
Summary of Study: Antibody response to SARS-CoV-2 in macaques shares many features with humans, but with substantial differences in the recognition of certain epitopes and considerable individual variability in antibody escape profiles, suggesting a diverse repertoire of antibodies that can respond to major epitopes in both humans and macaques.
References: doi: 10.1101/2021.12.01.470697
Contact Info: Julie Overbaugh: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.12.01.470697v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Fred Hutchinson Cancer Research Center; University of Washington; Washington National Primate Research Center; HDT Bio; NIAID
Keywords: SARS-CoV-2, phage-based deep mutational scanning approach, spike protein, immune response, primates
Summary of Study: Antibody response to SARS-CoV-2 in macaques shares many features with humans, but with substantial differences in the recognition of certain epitopes and considerable individual variability in antibody escape profiles, suggesting a diverse repertoire of antibodies that can respond to major epitopes in both humans and macaques.
References: doi: 10.1101/2021.12.01.470697
Contact Info: Julie Overbaugh: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.12.01.470697v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Tulane National Primate Research Center, Northwestern University, Duke University Medical Center, Tulane School of Medicine
Keywords: SARS-CoV-2, monoclonal antibodies, neutralization, mucosal viral challenge, immune response, primates
Summary of Study: A combination of two mAbs demonstrated that administration of these mAbs at a range of doses achieved near-complete protection from viral replication and disease even when challenge occurred 75 days after mAb administration.
References: doi: 10.1101/2021.05.26.445878
Contact Info: Chad Roy: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.05.26.445878v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Tulane National Primate Research Center, Northwestern University, Duke University Medical Center, Tulane School of Medicine
Keywords: SARS-CoV-2, monoclonal antibodies, neutralization, mucosal viral challenge, immune response, primates
Summary of Study: A combination of two mAbs demonstrated that administration of these mAbs at a range of doses achieved near-complete protection from viral replication and disease even when challenge occurred 75 days after mAb administration.
References: doi: 10.1101/2021.05.26.445878
Contact Info: Chad Roy: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.05.26.445878v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center; Washington University SOM; TX Biomedical Research Institute; Tulane University
Keywords: SARS-CoV-2, bronchoalveolar lavage, transcription profiling, immune response, primates
Summary of Study: The recruitment of a myeloid-cell-mediated Type I IFN response is associated with the rapid clearance of SARS-CoV-2 infection in macaques.
References: PMID: 34282414 / doi: 10.21203/rs.3.rs-664507/v1
Contact Info: Dhiraj Singh: [email protected]
URL: https://www.researchsquare.com/article/rs-664507/v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center; Washington University SOM; TX Biomedical Research Institute; Tulane University
Keywords: SARS-CoV-2, bronchoalveolar lavage, transcription profiling, immune response, primates
Summary of Study: The recruitment of a myeloid-cell-mediated Type I IFN response is associated with the rapid clearance of SARS-CoV-2 infection in macaques.
References: PMID: 34282414 / doi: 10.21203/rs.3.rs-664507/v1
Contact Info: Dhiraj Singh: [email protected]
URL: https://www.researchsquare.com/article/rs-664507/v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets, howler monkeys
Year Published:
Study Type/Review:
NPRC/Institute: Instituto Federal do Norte de Minas Gerais, Brazil; Universidade de Brasilia; State University of Santa Cruz, and others
Keywords: SARS-CoV-2, wild animals, epidemiology, neotropical primates
Summary of Study: 51 neotropical NHPs were examined for serological and virological evidence of SARS-CoV-2 infections. No evidence of viral spillover into these populations was found.
References: doi: 10.1101/2021.06.17.448890
Contact Info: Danilo Bretas deOliveira: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.06.17.448890v1
NHP Species: marmosets, howler monkeys
Year Published:
Study Type/Review:
NPRC/Institute: Instituto Federal do Norte de Minas Gerais, Brazil; Universidade de Brasilia; State University of Santa Cruz, and others
Keywords: SARS-CoV-2, wild animals, epidemiology, neotropical primates
Summary of Study: 51 neotropical NHPs were examined for serological and virological evidence of SARS-CoV-2 infections. No evidence of viral spillover into these populations was found.
References: doi: 10.1101/2021.06.17.448890
Contact Info: Danilo Bretas deOliveira: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.06.17.448890v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Yerkes National Primate Research Center, Emory University; Emory University School of Medicine; University of Pittsburgh
Keywords: SARS-CoV-2, multi-omic analyses, inflammation, immune response, primates
Summary of Study: Multi-omic analyses of hyperacute SARS-CoV-2 infection in rhesus macaques identified two populations of infiltrating macrophages as the primary orchestrators of inflammation in the lower airway that can be successfully treated with baricitinib.
References: PMID: 34642693 / doi: 10.1101/2021.10.05.463212
Contact Info: Steven Bosinger: [email protected]; Mirko Paiardini: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.10.05.463212v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Yerkes National Primate Research Center, Emory University; Emory University School of Medicine; University of Pittsburgh
Keywords: SARS-CoV-2, multi-omic analyses, inflammation, immune response, primates
Summary of Study: Multi-omic analyses of hyperacute SARS-CoV-2 infection in rhesus macaques identified two populations of infiltrating macrophages as the primary orchestrators of inflammation in the lower airway that can be successfully treated with baricitinib.
References: PMID: 34642693 / doi: 10.1101/2021.10.05.463212
Contact Info: Steven Bosinger: [email protected]; Mirko Paiardini: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.10.05.463212v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published:
Study Type/Review:
NPRC/Institute: Selva Therapeutics, Tulane National Primate Research Center, University of Texas Medical Branch, UC San Diego,
Keywords: SARS-CoV-2,cysteine protease inhibitors, antiviral effects, pathology, primates
Summary of Study: SLV is an orally available treatment likely to reduce the respiratory symptoms associated with clinical progression in COVID-19 patients. African green monkey studies with this drug demonstrated a reduction in lung weight and a reduction in coronavirus-mediated pathology in both prophylactic and treatment settings. A Phase I trial with SLV213 has recently been completed and a Phase II trial is planned (https://clinicaltrials.gov/ct2/show/NCT04843787).
References: doi: 10.1101/2021.07.20.453127
Contact Info: Felix Frueh: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.07.20.453127v1
NHP Species: african green monkeys
Year Published:
Study Type/Review:
NPRC/Institute: Selva Therapeutics, Tulane National Primate Research Center, University of Texas Medical Branch, UC San Diego,
Keywords: SARS-CoV-2,cysteine protease inhibitors, antiviral effects, pathology, primates
Summary of Study: SLV is an orally available treatment likely to reduce the respiratory symptoms associated with clinical progression in COVID-19 patients. African green monkey studies with this drug demonstrated a reduction in lung weight and a reduction in coronavirus-mediated pathology in both prophylactic and treatment settings. A Phase I trial with SLV213 has recently been completed and a Phase II trial is planned (https://clinicaltrials.gov/ct2/show/NCT04843787).
References: doi: 10.1101/2021.07.20.453127
Contact Info: Felix Frueh: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.07.20.453127v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: The 4th R&D Institute, Agency for Defense Development, Yuseong, P.O. Box 35, Daejeon 34186, Republic of Korea
Keywords: SARS-CoV-2, siRNA inhibitors, hamster and primates
Summary of Study: An siRNA targeting RNA-dependent RNA polymerase (RdRp) showed a reduction in SARS-CoV-2 infection-induced fever and virus titer in the Golden Syrian hamster and rhesus macaque. These results suggest the potential for RdRp targeting siRNA as a new treatment for the coronavirus disease 2019 (COVID-19).
References: doi: https://doi.org/10.1101/2020.07.07.190967
Contact Info: Seong Tae Jeong at [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.07.07.190967v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: The 4th R&D Institute, Agency for Defense Development, Yuseong, P.O. Box 35, Daejeon 34186, Republic of Korea
Keywords: SARS-CoV-2, siRNA inhibitors, hamster and primates
Summary of Study: An siRNA targeting RNA-dependent RNA polymerase (RdRp) showed a reduction in SARS-CoV-2 infection-induced fever and virus titer in the Golden Syrian hamster and rhesus macaque. These results suggest the potential for RdRp targeting siRNA as a new treatment for the coronavirus disease 2019 (COVID-19).
References: doi: https://doi.org/10.1101/2020.07.07.190967
Contact Info: Seong Tae Jeong at [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.07.07.190967v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Washington Univ., Texas Biomedical Research Institute, and others
Keywords: SARS-CoV-2, spike ferritin nanoparticle vaccine, immune response, pathology, primates
Summary of Study: A SARS-CoV-2 spike protein ferritin nanoparticle vaccine, co-formulated with a liposomal adjuvant, elicits broad neutralizing antibody responses that exceed those observed for other major vaccines and rapidly protects against respiratory infection and disease in the upper and lower airways and lung tissue of NHPs.
References: PMID: 33791694 / doi: 10.1101/2021.03.24.436523
Contact Info: Kayvon Modjarrad: [email protected]; Michael Joyce: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.03.24.436523v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Washington Univ., Texas Biomedical Research Institute, and others
Keywords: SARS-CoV-2, spike ferritin nanoparticle vaccine, immune response, pathology, primates
Summary of Study: A SARS-CoV-2 spike protein ferritin nanoparticle vaccine, co-formulated with a liposomal adjuvant, elicits broad neutralizing antibody responses that exceed those observed for other major vaccines and rapidly protects against respiratory infection and disease in the upper and lower airways and lung tissue of NHPs.
References: PMID: 33791694 / doi: 10.1101/2021.03.24.436523
Contact Info: Kayvon Modjarrad: [email protected]; Michael Joyce: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.03.24.436523v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Vyriad Inc.; Imanis Life Sciences; Mayo Clinic; Regeneron Pharmaceuticals, Inc.; University of Minnesota
Keywords: SARS-CoV-2, oral rhabdoviral vaccine, boost, immune response, primates
Summary of Study: A relevant translational NHP model was used to demonstrate the safety and oral immunogenicity of a VSV-derived mucosal vaccine for SARS-CoV-2. Pre-IND discussion with FDA are ongoing.
References: doi: 10.1101/2021.10.16.464660
Contact Info: Stephen Russell: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.10.16.464660v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Vyriad Inc.; Imanis Life Sciences; Mayo Clinic; Regeneron Pharmaceuticals, Inc.; University of Minnesota
Keywords: SARS-CoV-2, oral rhabdoviral vaccine, boost, immune response, primates
Summary of Study: A relevant translational NHP model was used to demonstrate the safety and oral immunogenicity of a VSV-derived mucosal vaccine for SARS-CoV-2. Pre-IND discussion with FDA are ongoing.
References: doi: 10.1101/2021.10.16.464660
Contact Info: Stephen Russell: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.10.16.464660v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Harvard, MIT, Emory University School of Medicine, Yerkes National Primate Research Center and others
Keywords: SARS-CoV-2, adjuvanted soluble protein vaccine, binding and functional neutralization assays, serology, primates
Summary of Study: Antibodies induced by the AS03-adjuvanted preS dTM vaccine are sufficient to mediate protection against SARS-CoV-2 and support the evaluation of this vaccine in human clinical trials.
References: PMID: 33688652 / doi: 10.1101/2021.03.02.433390
Contact Info: Robert Seder: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.03.02.433390v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Harvard, MIT, Emory University School of Medicine, Yerkes National Primate Research Center and others
Keywords: SARS-CoV-2, adjuvanted soluble protein vaccine, binding and functional neutralization assays, serology, primates
Summary of Study: Antibodies induced by the AS03-adjuvanted preS dTM vaccine are sufficient to mediate protection against SARS-CoV-2 and support the evaluation of this vaccine in human clinical trials.
References: PMID: 33688652 / doi: 10.1101/2021.03.02.433390
Contact Info: Robert Seder: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.03.02.433390v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Yerkes National Primate Research Center; University of Pittsburgh; Emory University School of Medicine
Keywords: SARS-CoV-2, macrophages, inflammation, mRNA analysis, kinase inhibitor, primates
Summary of Study: Multi-omic analyses of hyperacute SARS-CoV-2 infection in rhesus macaques identified two populations of infiltrating macrophages as the primary orchestrators of inflammation in the lower airway that can be successfully treated with baricitinib.
References: doi: 10.1101/2021.10.05.463212
Contact Info: Steven Bosinger: [email protected]; Mirko Paiardini: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.10.05.463212v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Yerkes National Primate Research Center; University of Pittsburgh; Emory University School of Medicine
Keywords: SARS-CoV-2, macrophages, inflammation, mRNA analysis, kinase inhibitor, primates
Summary of Study: Multi-omic analyses of hyperacute SARS-CoV-2 infection in rhesus macaques identified two populations of infiltrating macrophages as the primary orchestrators of inflammation in the lower airway that can be successfully treated with baricitinib.
References: doi: 10.1101/2021.10.05.463212
Contact Info: Steven Bosinger: [email protected]; Mirko Paiardini: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.10.05.463212v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID; Yerkes National Primate Research Center; Emory University School of Medicine; Bioqual; Moderna
Keywords: SARS-CoV-2, mRNA-vaccine, immune response, protection, virus reproduction, primates
Summary of Study: mRNA-1273 provided durable protection against B.1.617.2 challenge in the lower airways likely through anamnestic induction of antibody responses in the lung.
References: PMID: 34729558 / doi: 10.1101/2021.10.23.465542
Contact Info: Robert Seder: [email protected]; Daniel Douek: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.10.23.465542v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID; Yerkes National Primate Research Center; Emory University School of Medicine; Bioqual; Moderna
Keywords: SARS-CoV-2, mRNA-vaccine, immune response, protection, virus reproduction, primates
Summary of Study: mRNA-1273 provided durable protection against B.1.617.2 challenge in the lower airways likely through anamnestic induction of antibody responses in the lung.
References: PMID: 34729558 / doi: 10.1101/2021.10.23.465542
Contact Info: Robert Seder: [email protected]; Daniel Douek: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.10.23.465542v1