Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published:
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Zalgen Labs, LLC., Duke University Medical Center
Keywords: SARS-CoV-2, route of experimental infection, immune response, pathology, primates
Summary of Study: Lack of regenerative activity in the lung was present in both species post-resolution of most of the viral RNA, indicating the NHP model of SARS-CoV-2 infection can be utilized during anti-fibrosis therapeutic development and evaluation and has potential utility in evaluation of post-acute COVID sequelae.
References: doi: 10.1101/2021.11.28.470250
Contact Info: Chad Roy: croy@tulane.edu
URL: https://www.biorxiv.org/content/10.1101/2021.11.28.470250v1
NHP Species: rhesus macaques, african green monkeys
Year Published:
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Zalgen Labs, LLC., Duke University Medical Center
Keywords: SARS-CoV-2, route of experimental infection, immune response, pathology, primates
Summary of Study: Lack of regenerative activity in the lung was present in both species post-resolution of most of the viral RNA, indicating the NHP model of SARS-CoV-2 infection can be utilized during anti-fibrosis therapeutic development and evaluation and has potential utility in evaluation of post-acute COVID sequelae.
References: doi: 10.1101/2021.11.28.470250
Contact Info: Chad Roy: croy@tulane.edu
URL: https://www.biorxiv.org/content/10.1101/2021.11.28.470250v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published:
Study Type/Review:
NPRC/Institute: Laboratory of Virology; NIAID/NIH; University of Plymouth; The Vaccine Group, Ltd.
Keywords: SARS-CoV-2, intranasal infection, genome variants, immune response, primates
Summary of Study: UK B.1.1.7 infection of African green monkeys exhibits increased respiratory replication and shedding but no disease enhancement.
References: PMID: 34159332 / doi: 10.1101/2021.06.11.448134
Contact Info: Heinz Feldmann: feldmannh@niaid.nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.06.11.448134v1
NHP Species: african green monkeys
Year Published:
Study Type/Review:
NPRC/Institute: Laboratory of Virology; NIAID/NIH; University of Plymouth; The Vaccine Group, Ltd.
Keywords: SARS-CoV-2, intranasal infection, genome variants, immune response, primates
Summary of Study: UK B.1.1.7 infection of African green monkeys exhibits increased respiratory replication and shedding but no disease enhancement.
References: PMID: 34159332 / doi: 10.1101/2021.06.11.448134
Contact Info: Heinz Feldmann: feldmannh@niaid.nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.06.11.448134v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: lemurs, lorises
Year Published:
Study Type/Review:
NPRC/Institute: Univ. of Calgary, Institut de Biologia Evolutiva, New York Univ., and others
Keywords: SARS-CoV-2, ACE2 gene and protein sequences, several species, primates
Summary of Study: Susceptibility to SARS-CoV-2 is not equal across non-human primates. This study suggests that several clades of lemurs have a high potential susceptibility to SARS-CoV-2 infection. As they are among the primates at highest risk of extinction globally, further understanding of their risk should be a conservation priority. All feasible actions should be taken to limit their exposure to SARS-CoV-2.
References: PMID: 33564767 / doi: 10.1101/2021.02.03.429540
Contact Info: James Higham: jhigham@nyu.edu; Amanda Melin: amanda.melin@ucalgary.ca
URL: https://www.biorxiv.org/content/10.1101/2021.02.03.429540v1
NHP Species: lemurs, lorises
Year Published:
Study Type/Review:
NPRC/Institute: Univ. of Calgary, Institut de Biologia Evolutiva, New York Univ., and others
Keywords: SARS-CoV-2, ACE2 gene and protein sequences, several species, primates
Summary of Study: Susceptibility to SARS-CoV-2 is not equal across non-human primates. This study suggests that several clades of lemurs have a high potential susceptibility to SARS-CoV-2 infection. As they are among the primates at highest risk of extinction globally, further understanding of their risk should be a conservation priority. All feasible actions should be taken to limit their exposure to SARS-CoV-2.
References: PMID: 33564767 / doi: 10.1101/2021.02.03.429540
Contact Info: James Higham: jhigham@nyu.edu; Amanda Melin: amanda.melin@ucalgary.ca
URL: https://www.biorxiv.org/content/10.1101/2021.02.03.429540v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Pathogen and Biosecurity, Beijing, China
Keywords: SARS-CoV-2, recombinant subunit vaccine, neutralization potency, aged animals, primates
Summary of Study: Authors developed a pilot scale pipeline producing a recombinant subunit vaccine (RBD-Fc Vacc) with Receptor Binding Domain of SARS-CoV-2S protein fused with the Fc domain of human IgG1. This vaccine induced SARS-CoV-2 specific neutralizing antibodies in non-human primates and human ACE2 transgenic mice and is currently being assessed in randomized controlled phase I/II human clinical trials.
References: doi: https://doi.org/10.1101/2020.11.29.402339
Contact Info: Yuwei Gao: gaoyuwei@gmail.com; Wenjin Wei: weiwenjin66@126.com; Zhonghu Hu: huzy67@163.com
URL: https://www.biorxiv.org/content/10.1101/2020.11.29.402339v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Pathogen and Biosecurity, Beijing, China
Keywords: SARS-CoV-2, recombinant subunit vaccine, neutralization potency, aged animals, primates
Summary of Study: Authors developed a pilot scale pipeline producing a recombinant subunit vaccine (RBD-Fc Vacc) with Receptor Binding Domain of SARS-CoV-2S protein fused with the Fc domain of human IgG1. This vaccine induced SARS-CoV-2 specific neutralizing antibodies in non-human primates and human ACE2 transgenic mice and is currently being assessed in randomized controlled phase I/II human clinical trials.
References: doi: https://doi.org/10.1101/2020.11.29.402339
Contact Info: Yuwei Gao: gaoyuwei@gmail.com; Wenjin Wei: weiwenjin66@126.com; Zhonghu Hu: huzy67@163.com
URL: https://www.biorxiv.org/content/10.1101/2020.11.29.402339v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Clover Biopharmaceuticals, Chengdu, China
Keywords: SARS-CoV-2, Trimer-Tag technology, neutralizing antibodies, primates
Summary of Study: Rhesus macaques immunized with adjuvanted S-Trimer were protected from SARS-CoV-2 challenge compared to vehicle controls. Trimer-Tag may be an important new platform technology for scalable production and rapid development of safe and effective subunit vaccines against current and future emerging RNA viruses.
References: doi: https://doi.org/10.1101/2020.09.24.311027
Contact Info: Pen Liang: liang.peng@cloverbiopharma.com
URL: https://www.biorxiv.org/content/10.1101/2020.09.24.311027v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Clover Biopharmaceuticals, Chengdu, China
Keywords: SARS-CoV-2, Trimer-Tag technology, neutralizing antibodies, primates
Summary of Study: Rhesus macaques immunized with adjuvanted S-Trimer were protected from SARS-CoV-2 challenge compared to vehicle controls. Trimer-Tag may be an important new platform technology for scalable production and rapid development of safe and effective subunit vaccines against current and future emerging RNA viruses.
References: doi: https://doi.org/10.1101/2020.09.24.311027
Contact Info: Pen Liang: liang.peng@cloverbiopharma.com
URL: https://www.biorxiv.org/content/10.1101/2020.09.24.311027v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Duke University, NIAID, 3 M Company
Keywords: SARS-CoV-2, receptor binding domain nanoparticle, vaccination, immune response, primates
Summary of Study: An RBD-scNP vaccine induced robust protective immunity for SARS-CoV-2 replication in the upper and lower respiratory tract. This vaccine represents a platform for producing a pancoronavirus vaccine that could prevent, rapidly temper, or extinguish the next spillover of a coronavirus into humans.
References: doi: 10.1101/2021.02.17.431492
Contact Info: Kevin Saunders: kevin.saunders@duke.edu; Barton Haynes: barton.haynes@duke.edu
URL: https://www.biorxiv.org/content/10.1101/2021.02.17.431492v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Duke University, NIAID, 3 M Company
Keywords: SARS-CoV-2, receptor binding domain nanoparticle, vaccination, immune response, primates
Summary of Study: An RBD-scNP vaccine induced robust protective immunity for SARS-CoV-2 replication in the upper and lower respiratory tract. This vaccine represents a platform for producing a pancoronavirus vaccine that could prevent, rapidly temper, or extinguish the next spillover of a coronavirus into humans.
References: doi: 10.1101/2021.02.17.431492
Contact Info: Kevin Saunders: kevin.saunders@duke.edu; Barton Haynes: barton.haynes@duke.edu
URL: https://www.biorxiv.org/content/10.1101/2021.02.17.431492v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center; Washington University SOM; TX Biomedical Research Institute; Tulane University
Keywords: SARS-CoV-2, bronchoalveolar lavage, transcription profiling, immune response, primates
Summary of Study: The recruitment of a myeloid-cell-mediated Type I IFN response is associated with the rapid clearance of SARS-CoV-2 infection in macaques.
References: PMID: 34282414 / doi: 10.21203/rs.3.rs-664507/v1
Contact Info: Dhiraj Singh: dkaushal@txbiomed.org
URL: https://www.researchsquare.com/article/rs-664507/v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center; Washington University SOM; TX Biomedical Research Institute; Tulane University
Keywords: SARS-CoV-2, bronchoalveolar lavage, transcription profiling, immune response, primates
Summary of Study: The recruitment of a myeloid-cell-mediated Type I IFN response is associated with the rapid clearance of SARS-CoV-2 infection in macaques.
References: PMID: 34282414 / doi: 10.21203/rs.3.rs-664507/v1
Contact Info: Dhiraj Singh: dkaushal@txbiomed.org
URL: https://www.researchsquare.com/article/rs-664507/v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Vyriad Inc.; Imanis Life Sciences; Mayo Clinic; Regeneron Pharmaceuticals, Inc.; University of Minnesota
Keywords: SARS-CoV-2, oral rhabdoviral vaccine, boost, immune response, primates
Summary of Study: A relevant translational NHP model was used to demonstrate the safety and oral immunogenicity of a VSV-derived mucosal vaccine for SARS-CoV-2. Pre-IND discussion with FDA are ongoing.
References: doi: 10.1101/2021.10.16.464660
Contact Info: Stephen Russell: sjrussell@vyriad.com
URL: https://www.biorxiv.org/content/10.1101/2021.10.16.464660v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Vyriad Inc.; Imanis Life Sciences; Mayo Clinic; Regeneron Pharmaceuticals, Inc.; University of Minnesota
Keywords: SARS-CoV-2, oral rhabdoviral vaccine, boost, immune response, primates
Summary of Study: A relevant translational NHP model was used to demonstrate the safety and oral immunogenicity of a VSV-derived mucosal vaccine for SARS-CoV-2. Pre-IND discussion with FDA are ongoing.
References: doi: 10.1101/2021.10.16.464660
Contact Info: Stephen Russell: sjrussell@vyriad.com
URL: https://www.biorxiv.org/content/10.1101/2021.10.16.464660v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, pigtail macaques
Year Published:
Study Type/Review:
NPRC/Institute: National Institute of Animal Biotechnology, Telangana, India
Keywords: SARS-CoV-2, ACE2 receptor of various species, several species.
Summary of Study: The interaction of SARS-CoV-2 spike receptor-binding domain with its receptor (ACE2) in different hosts was evaluated to understand and predict viral entry. Most of the species considered in this study showed high probability of viral entry and should be followed to determine their ability to act as carriers and/or disseminators.
References: doi: https://doi.org/10.1101/2020.05.08.084327
Contact Info: Ravi Kumar Gandham: ravigandham@niab.org.in
URL: https://www.biorxiv.org/content/10.1101/2020.05.08.084327v4
NHP Species: rhesus macaques, pigtail macaques
Year Published:
Study Type/Review:
NPRC/Institute: National Institute of Animal Biotechnology, Telangana, India
Keywords: SARS-CoV-2, ACE2 receptor of various species, several species.
Summary of Study: The interaction of SARS-CoV-2 spike receptor-binding domain with its receptor (ACE2) in different hosts was evaluated to understand and predict viral entry. Most of the species considered in this study showed high probability of viral entry and should be followed to determine their ability to act as carriers and/or disseminators.
References: doi: https://doi.org/10.1101/2020.05.08.084327
Contact Info: Ravi Kumar Gandham: ravigandham@niab.org.in
URL: https://www.biorxiv.org/content/10.1101/2020.05.08.084327v4
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Unviersity of Hawaii, Bioqual, Inc., Soligenix, Inc.
Keywords: SARS-CoV-2, recombinant subunit protein vaccine, spike protein, immune response, pathology, primates
Summary of Study: A recombinant subunit protein forumulated with CoVaccine HT adjuvant induces superior immunity than natural infection and reduces viral load while protecting cynomolgus macaques from COVID-19-like disease caused by late SARS-CoV-2 P.1 (Gamma) challenge.
References: doi: 10.1101/2021.09.24.461759
Contact Info: Axel Lehrer: lehrer@hawaii.edu
URL: https://www.biorxiv.org/content/10.1101/2021.09.24.461759v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Unviersity of Hawaii, Bioqual, Inc., Soligenix, Inc.
Keywords: SARS-CoV-2, recombinant subunit protein vaccine, spike protein, immune response, pathology, primates
Summary of Study: A recombinant subunit protein forumulated with CoVaccine HT adjuvant induces superior immunity than natural infection and reduces viral load while protecting cynomolgus macaques from COVID-19-like disease caused by late SARS-CoV-2 P.1 (Gamma) challenge.
References: doi: 10.1101/2021.09.24.461759
Contact Info: Axel Lehrer: lehrer@hawaii.edu
URL: https://www.biorxiv.org/content/10.1101/2021.09.24.461759v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: Duke University School of Medicine
Keywords: SARS-CoV-2, neutralizing and infection-enhancing antibodies, mice and primates
Summary of Study: SARS-CoV-2 antibodies can mediate infection enhancement in vitro. However, this in vitro phenotype does not translate to enhanced infection in a non-human primate model of SARS-CoV-2 infection. These preclinical results indicate that SARS-CoV-2 antibody treatments or the induction of SARS-CoV-2 antibodies by vaccination have a low likelihood of exacerbating COVID-19 disease in humans.
References: doi: https://doi.org/10.1101/2020.12.31.424729
Contact Info: Barton Haynes: barton.haynes@duke.edu/Kevin Saunders: kevin.saunders@duke.edu
URL: https://www.biorxiv.org/content/10.1101/2020.12.31.424729v2
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: Duke University School of Medicine
Keywords: SARS-CoV-2, neutralizing and infection-enhancing antibodies, mice and primates
Summary of Study: SARS-CoV-2 antibodies can mediate infection enhancement in vitro. However, this in vitro phenotype does not translate to enhanced infection in a non-human primate model of SARS-CoV-2 infection. These preclinical results indicate that SARS-CoV-2 antibody treatments or the induction of SARS-CoV-2 antibodies by vaccination have a low likelihood of exacerbating COVID-19 disease in humans.
References: doi: https://doi.org/10.1101/2020.12.31.424729
Contact Info: Barton Haynes: barton.haynes@duke.edu/Kevin Saunders: kevin.saunders@duke.edu
URL: https://www.biorxiv.org/content/10.1101/2020.12.31.424729v2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: University of Pennsylvania
Keywords: SARS-CoV-2, vaccine, pseudovirus, neutralizing antibodies, mice, primates, humans
Summary of Study: SARs-CoV-2 recently mutated near the region targeted by many vaccines. The current study tested whether the mutation would hinder the ability of current vaccines to induce neutralizing antibodies in mice/NHPs/human serum. Their results indicate the viral mutation will not interfere with the effects of vaccines developed based on the original protein structure.
References: doi: 10.1101/2020.07.22.20159905
Contact Info: Drew Weissman, Email: Drew@pennmedicine.upenn.edu OR Davis Montefiori, email: david.montefiori@duke.edu
URL: https://www.medrxiv.org/content/10.1101/2020.07.22.20159905v2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: University of Pennsylvania
Keywords: SARS-CoV-2, vaccine, pseudovirus, neutralizing antibodies, mice, primates, humans
Summary of Study: SARs-CoV-2 recently mutated near the region targeted by many vaccines. The current study tested whether the mutation would hinder the ability of current vaccines to induce neutralizing antibodies in mice/NHPs/human serum. Their results indicate the viral mutation will not interfere with the effects of vaccines developed based on the original protein structure.
References: doi: 10.1101/2020.07.22.20159905
Contact Info: Drew Weissman, Email: Drew@pennmedicine.upenn.edu OR Davis Montefiori, email: david.montefiori@duke.edu
URL: https://www.medrxiv.org/content/10.1101/2020.07.22.20159905v2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Walter Reed National Military Medical Center; Bioqual; University of Pittsburgh Medical Center; Henry Jackson Foundation; Ragon Institute of MGH, MIT, and Harvard
Keywords: SARS-CoV-2, live oral vaccine, gastrointestinal tract, pathology, immune response, primates
Summary of Study: Post-pyloric inoculation of live SARS-CoV-2 is weakly immunogenic and confers partial protection against respiratory SARS-CoV-2 challenge in rhesus macaques.
References: doi: 10.1128/JVI.01599-21
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://journals.asm.org/doi/10.1128/JVI.01599-21?url_ver=Z39.88-2003&rfr_id=or…
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Walter Reed National Military Medical Center; Bioqual; University of Pittsburgh Medical Center; Henry Jackson Foundation; Ragon Institute of MGH, MIT, and Harvard
Keywords: SARS-CoV-2, live oral vaccine, gastrointestinal tract, pathology, immune response, primates
Summary of Study: Post-pyloric inoculation of live SARS-CoV-2 is weakly immunogenic and confers partial protection against respiratory SARS-CoV-2 challenge in rhesus macaques.
References: doi: 10.1128/JVI.01599-21
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://journals.asm.org/doi/10.1128/JVI.01599-21?url_ver=Z39.88-2003&rfr_id=or…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID; Yerkes National Primate Research Center; Emory University School of Medicine; Bioqual; Moderna
Keywords: SARS-CoV-2, mRNA-vaccine, immune response, protection, virus reproduction, primates
Summary of Study: mRNA-1273 provided durable protection against B.1.617.2 challenge in the lower airways likely through anamnestic induction of antibody responses in the lung.
References: PMID: 34729558 / doi: 10.1101/2021.10.23.465542
Contact Info: Robert Seder: rseder@mail.nih.gov; Daniel Douek: ddouek@mail.nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.10.23.465542v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID; Yerkes National Primate Research Center; Emory University School of Medicine; Bioqual; Moderna
Keywords: SARS-CoV-2, mRNA-vaccine, immune response, protection, virus reproduction, primates
Summary of Study: mRNA-1273 provided durable protection against B.1.617.2 challenge in the lower airways likely through anamnestic induction of antibody responses in the lung.
References: PMID: 34729558 / doi: 10.1101/2021.10.23.465542
Contact Info: Robert Seder: rseder@mail.nih.gov; Daniel Douek: ddouek@mail.nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.10.23.465542v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan
Keywords: SARS-CoV-2, therapeutics, an iodine complex, primates
Summary of Study: Renessans, an iodine complex which has proven in vitro antiretroviral activity, may result in early clearance of SARS-CoV-2.
References: doi: https://doi.org/10.1101/2020.11.17.377432
Contact Info: Tahir Yaqub: tahiryaqub@uvas.edu.pk
URL: https://www.biorxiv.org/content/10.1101/2020.11.17.377432v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan
Keywords: SARS-CoV-2, therapeutics, an iodine complex, primates
Summary of Study: Renessans, an iodine complex which has proven in vitro antiretroviral activity, may result in early clearance of SARS-CoV-2.
References: doi: https://doi.org/10.1101/2020.11.17.377432
Contact Info: Tahir Yaqub: tahiryaqub@uvas.edu.pk
URL: https://www.biorxiv.org/content/10.1101/2020.11.17.377432v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID, Emory University, Duke University, Moderna, Bioqual
Keywords: SARS-CoV-2, mRNA vaccine, lipid nanoparticles, immune response, pathology, primates
Summary of Study: mRNA-1273 vaccine-induced antibody responses are a mechanistic correlate of protection against SARS-CoV-2 infection in NHP.
References: PMID: 33907752 / doi: 10.1101/2021.04.20.44067
Contact Info: Robert Seder: rseder@mail.nih.gov; Barney Graham: bgraham@nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.04.20.440647v2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID, Emory University, Duke University, Moderna, Bioqual
Keywords: SARS-CoV-2, mRNA vaccine, lipid nanoparticles, immune response, pathology, primates
Summary of Study: mRNA-1273 vaccine-induced antibody responses are a mechanistic correlate of protection against SARS-CoV-2 infection in NHP.
References: PMID: 33907752 / doi: 10.1101/2021.04.20.44067
Contact Info: Robert Seder: rseder@mail.nih.gov; Barney Graham: bgraham@nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.04.20.440647v2
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: University of Maryland School of Medicine; Noravax
Keywords: SARS-CoV-2, receptor-binding domain subunit vaccine, immune response, mice and primates
Summary of Study: Positive results in non-human primates suggest the feasibility of utilizing a B.1.351 Spike directed variant vaccine as a booster after previous immunization with a vaccine directed toward the ancestral SARS-CoV-2 Spike protein.
References: doi: 10.1101/2021.06.08.447631
Contact Info: Matthew Frieman: mfrieman@som.umaryland.edu
URL: https://www.biorxiv.org/content/10.1101/2021.06.08.447631v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: University of Maryland School of Medicine; Noravax
Keywords: SARS-CoV-2, receptor-binding domain subunit vaccine, immune response, mice and primates
Summary of Study: Positive results in non-human primates suggest the feasibility of utilizing a B.1.351 Spike directed variant vaccine as a booster after previous immunization with a vaccine directed toward the ancestral SARS-CoV-2 Spike protein.
References: doi: 10.1101/2021.06.08.447631
Contact Info: Matthew Frieman: mfrieman@som.umaryland.edu
URL: https://www.biorxiv.org/content/10.1101/2021.06.08.447631v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID, Emory University
Keywords: SARS-CoV-2, mRNA vaccine, virus genome variants, immune response, pathology, primates
Summary of Study: Immunization with two doses of mRNA-1273 achieves effective immunity that rapidly controls lower and upper airway viral replication against the B-1.351 variant in NHP.
References: PMID: 34075375 / doi: 10.1101/2021.05.21.445189
Contact Info: Barney Graham: bgraham@nih.gov; Robert Seder: rseder@mail.nih.gov;
URL: https://www.biorxiv.org/content/10.1101/2021.05.21.445189v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID, Emory University
Keywords: SARS-CoV-2, mRNA vaccine, virus genome variants, immune response, pathology, primates
Summary of Study: Immunization with two doses of mRNA-1273 achieves effective immunity that rapidly controls lower and upper airway viral replication against the B-1.351 variant in NHP.
References: PMID: 34075375 / doi: 10.1101/2021.05.21.445189
Contact Info: Barney Graham: bgraham@nih.gov; Robert Seder: rseder@mail.nih.gov;
URL: https://www.biorxiv.org/content/10.1101/2021.05.21.445189v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID; CureVac AG
Keywords: SARS-CoV-2, mRNA vaccine, immune response, primates
Summary of Study: Prime-boost vaccination with 4 ug of vaccine candidate CV07050101 resulted in limited immune responses in 4 out of 6 non-human primates.
References: doi: 10.1101/2021.07.07.451505
Contact Info: Vincent Munster: vincent.munster@nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.07.07.451505v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID; CureVac AG
Keywords: SARS-CoV-2, mRNA vaccine, immune response, primates
Summary of Study: Prime-boost vaccination with 4 ug of vaccine candidate CV07050101 resulted in limited immune responses in 4 out of 6 non-human primates.
References: doi: 10.1101/2021.07.07.451505
Contact Info: Vincent Munster: vincent.munster@nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.07.07.451505v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: National Institute of Allergy and
Infectious Diseases, National Institutes of Health; Washington National Primate Research Center, University of Washington; HDT Bio; Fred Hutchinson Cancer Research Center
Keywords: SARS-CoV-2, replicon RNA vaccine, neutralizing antibody response, pathology, primates
Summary of Study: A self-amplifying replicon RNA vaccine elicits protective immunity to COVID-19 and a strong protective response even after antibody levels decreased to undetectable levels.
References: PMID: 35982677 / doi: 10.1101/2022.08.08.503239
Contact Info: Deborah Heydenburg Fuller; Jesse H. Erasmus
URL: https://www.biorxiv.org/content/10.1101/2022.08.08.503239v1
NHP Species: pigtail macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: National Institute of Allergy and
Infectious Diseases, National Institutes of Health; Washington National Primate Research Center, University of Washington; HDT Bio; Fred Hutchinson Cancer Research Center
Keywords: SARS-CoV-2, replicon RNA vaccine, neutralizing antibody response, pathology, primates
Summary of Study: A self-amplifying replicon RNA vaccine elicits protective immunity to COVID-19 and a strong protective response even after antibody levels decreased to undetectable levels.
References: PMID: 35982677 / doi: 10.1101/2022.08.08.503239
Contact Info: Deborah Heydenburg Fuller; Jesse H. Erasmus
URL: https://www.biorxiv.org/content/10.1101/2022.08.08.503239v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: pathogenesis
NPRC/Institute: Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, United States; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Keywords: SARS-CoV-2, neutralizing antibodies, immune response, anatomic compartments, primates
Summary of Study: Compartment-Specific Antibody Correlates of Protection to SARS-CoV-2 Omicron
References: PMID: 38464001 PMCID: PMC10925337 DOI: 10.1101/2024.03.01.582951
Contact Info: Dan H. Barouch: dbarouch@bidmc.harvard.edu; Ryan McNamara: rpmcnamara@mgh.harvard.edu
URL: https://www.biorxiv.org/content/10.1101/2024.03.01.582951v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: pathogenesis
NPRC/Institute: Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, United States; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Keywords: SARS-CoV-2, neutralizing antibodies, immune response, anatomic compartments, primates
Summary of Study: Compartment-Specific Antibody Correlates of Protection to SARS-CoV-2 Omicron
References: PMID: 38464001 PMCID: PMC10925337 DOI: 10.1101/2024.03.01.582951
Contact Info: Dan H. Barouch: dbarouch@bidmc.harvard.edu; Ryan McNamara: rpmcnamara@mgh.harvard.edu
URL: https://www.biorxiv.org/content/10.1101/2024.03.01.582951v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets, howler monkeys
Year Published:
Study Type/Review:
NPRC/Institute: Instituto Federal do Norte de Minas Gerais, Brazil; Universidade de Brasilia; State University of Santa Cruz, and others
Keywords: SARS-CoV-2, wild animals, epidemiology, neotropical primates
Summary of Study: 51 neotropical NHPs were examined for serological and virological evidence of SARS-CoV-2 infections. No evidence of viral spillover into these populations was found.
References: doi: 10.1101/2021.06.17.448890
Contact Info: Danilo Bretas deOliveira: danilo.bretas@ufvjm.edu.br
URL: https://www.biorxiv.org/content/10.1101/2021.06.17.448890v1
NHP Species: marmosets, howler monkeys
Year Published:
Study Type/Review:
NPRC/Institute: Instituto Federal do Norte de Minas Gerais, Brazil; Universidade de Brasilia; State University of Santa Cruz, and others
Keywords: SARS-CoV-2, wild animals, epidemiology, neotropical primates
Summary of Study: 51 neotropical NHPs were examined for serological and virological evidence of SARS-CoV-2 infections. No evidence of viral spillover into these populations was found.
References: doi: 10.1101/2021.06.17.448890
Contact Info: Danilo Bretas deOliveira: danilo.bretas@ufvjm.edu.br
URL: https://www.biorxiv.org/content/10.1101/2021.06.17.448890v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published:
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center, Tulane University School of Medicine
Keywords: SARS-CoV-2, viral RNA, evolution, genomic variants, primates
Summary of Study: Study confirmed importance of an intact furin cleavage site for SARS-CoV-2 infection in vivo; a new SARS-CoV-2 strain exclusive to the African green monkey species was identified.
References: doi: 10.1101/2021.08.22.457295
Contact Info: Nicolas Maness: nmaness@tulane.edu
URL: https://www.biorxiv.org/content/10.1101/2021.08.22.457295v1.full
NHP Species: african green monkeys
Year Published:
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center, Tulane University School of Medicine
Keywords: SARS-CoV-2, viral RNA, evolution, genomic variants, primates
Summary of Study: Study confirmed importance of an intact furin cleavage site for SARS-CoV-2 infection in vivo; a new SARS-CoV-2 strain exclusive to the African green monkey species was identified.
References: doi: 10.1101/2021.08.22.457295
Contact Info: Nicolas Maness: nmaness@tulane.edu
URL: https://www.biorxiv.org/content/10.1101/2021.08.22.457295v1.full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: CureVac AG Tuebingen, Germany
Keywords: SARS-CoV-2, mRNA vaccine CVnCoV, safety, immunogenicity, and protective efficacy, primates
Summary of Study: The efficacy of CVnCoV, a lipid-nanoparticle encapsulated, sequence optimized mRNA-based SARS-CoV-2 vaccine was evaluated. The study demonstrates that CVnCoV induces robust humoral and cellular responses in non-human primates. These results demonstrate safety, immunogenicity, and protective efficacy of this vaccine that extend beyond previously published preclinical data and provide strong support for further clinical testing in ongoing phase 2b/3 efficacy studies.
References: doi: https://doi.org/10.1101/2020.12.23.424138
Contact Info: no contact information provided
URL: https://www.biorxiv.org/content/10.1101/2020.12.23.424138v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: CureVac AG Tuebingen, Germany
Keywords: SARS-CoV-2, mRNA vaccine CVnCoV, safety, immunogenicity, and protective efficacy, primates
Summary of Study: The efficacy of CVnCoV, a lipid-nanoparticle encapsulated, sequence optimized mRNA-based SARS-CoV-2 vaccine was evaluated. The study demonstrates that CVnCoV induces robust humoral and cellular responses in non-human primates. These results demonstrate safety, immunogenicity, and protective efficacy of this vaccine that extend beyond previously published preclinical data and provide strong support for further clinical testing in ongoing phase 2b/3 efficacy studies.
References: doi: https://doi.org/10.1101/2020.12.23.424138
Contact Info: no contact information provided
URL: https://www.biorxiv.org/content/10.1101/2020.12.23.424138v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Tulane NPRC
Keywords: SARS-CoV-2, immune response, primates
Summary of Study: Increased levels of monocytes and chemokines after infection is associated with viral load and disease severity
References: doi: https://doi.org/10.1101/2020.07.21.213777
Contact Info: Monica Vaccari, mvaccari@tulane.edu
URL: https://www.biorxiv.org/content/10.1101/2020.07.21.213777v1%20
NHP Species: african green monkeys, rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Tulane NPRC
Keywords: SARS-CoV-2, immune response, primates
Summary of Study: Increased levels of monocytes and chemokines after infection is associated with viral load and disease severity
References: doi: https://doi.org/10.1101/2020.07.21.213777
Contact Info: Monica Vaccari, mvaccari@tulane.edu
URL: https://www.biorxiv.org/content/10.1101/2020.07.21.213777v1%20
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Fred Hutchinson Cancer Research Center; University of Washington; Washington National Primate Research Center; HDT Bio; NIAID
Keywords: SARS-CoV-2, phage-based deep mutational scanning approach, spike protein, immune response, primates
Summary of Study: Antibody response to SARS-CoV-2 in macaques shares many features with humans, but with substantial differences in the recognition of certain epitopes and considerable individual variability in antibody escape profiles, suggesting a diverse repertoire of antibodies that can respond to major epitopes in both humans and macaques.
References: doi: 10.1101/2021.12.01.470697
Contact Info: Julie Overbaugh: joverbau@fredhutch.org
URL: https://www.biorxiv.org/content/10.1101/2021.12.01.470697v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Fred Hutchinson Cancer Research Center; University of Washington; Washington National Primate Research Center; HDT Bio; NIAID
Keywords: SARS-CoV-2, phage-based deep mutational scanning approach, spike protein, immune response, primates
Summary of Study: Antibody response to SARS-CoV-2 in macaques shares many features with humans, but with substantial differences in the recognition of certain epitopes and considerable individual variability in antibody escape profiles, suggesting a diverse repertoire of antibodies that can respond to major epitopes in both humans and macaques.
References: doi: 10.1101/2021.12.01.470697
Contact Info: Julie Overbaugh: joverbau@fredhutch.org
URL: https://www.biorxiv.org/content/10.1101/2021.12.01.470697v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NCI/NIH; BIOQUAL, Inc.; NIAID; Alchem Laboratories; Frederick National Laboratory for Cancer Research
Keywords: SARS-CoV-2, virus genomic variants, mucosal booster vaccine, immune response, primates
Summary of Study: Following SARS-CoV-2 beta variant challenge, NHPs that received one intranasal beta-variant booster demonstrated significant protection against viral replication in the upper and lower respiratory tracts, with almost full protection in the nasal cavity.
References: doi: 10.1101/2021.10.19.464990
Contact Info: Yongjun Sui: suiy@mail.nih.gov; Jay Berzofsky: berzofsj@mail.nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.10.19.464990v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NCI/NIH; BIOQUAL, Inc.; NIAID; Alchem Laboratories; Frederick National Laboratory for Cancer Research
Keywords: SARS-CoV-2, virus genomic variants, mucosal booster vaccine, immune response, primates
Summary of Study: Following SARS-CoV-2 beta variant challenge, NHPs that received one intranasal beta-variant booster demonstrated significant protection against viral replication in the upper and lower respiratory tracts, with almost full protection in the nasal cavity.
References: doi: 10.1101/2021.10.19.464990
Contact Info: Yongjun Sui: suiy@mail.nih.gov; Jay Berzofsky: berzofsj@mail.nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.10.19.464990v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: School of Biological Science and Medical Engineering, Beihang University, Beijing
Keywords: SARS-CoV-2, S-protein-based linear B-cell epitope candidates, several species
Summary of Study: Four top prioritized linear B-cell epitopes in the hotspot regions of S protein can specifically bind with serum antibodies from rhesus monkeys inoculated with different SARS-CoV-2 vaccine candidates or a patient recovering from COVID-19. This study suggests that the four linear B-cell epitopes are potentially important candidates for serological assay or vaccine development.
References: doi: https://doi.org/10.1101/2020.12.13.422550
Contact Info: Jing Zhang: jz2716@buaa.edu.cn/Hui Wang: geno0109@vip.sina.com
URL: https://www.biorxiv.org/content/10.1101/2020.12.13.422550v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: School of Biological Science and Medical Engineering, Beihang University, Beijing
Keywords: SARS-CoV-2, S-protein-based linear B-cell epitope candidates, several species
Summary of Study: Four top prioritized linear B-cell epitopes in the hotspot regions of S protein can specifically bind with serum antibodies from rhesus monkeys inoculated with different SARS-CoV-2 vaccine candidates or a patient recovering from COVID-19. This study suggests that the four linear B-cell epitopes are potentially important candidates for serological assay or vaccine development.
References: doi: https://doi.org/10.1101/2020.12.13.422550
Contact Info: Jing Zhang: jz2716@buaa.edu.cn/Hui Wang: geno0109@vip.sina.com
URL: https://www.biorxiv.org/content/10.1101/2020.12.13.422550v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Shenzhen Hospital, Southern Medical University, Shenzhen, China
Keywords: SARS-CoV-2, adenovirus vectored vaccines, immunization, primates
Summary of Study: Two novel adenovirus vectored COVID-19 vaccines were produced, which, when used in succession, elicited robust humoral and T-cell immune response to SARS-CoV-2 in mice and rhesus macaques. These two vaccines are being planned for clinical phase I/II trials after an extensive safety evaluation has been carried out in pre-clinical animal examination.
References: doi: https://doi.org/10.1101/2020.09.28.311480
Contact Info: Chengyao Li: chengyaoli@hotmail.com; Tingting L: aple-ting-007@163.com
URL: https://www.biorxiv.org/content/10.1101/2020.09.28.311480v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Shenzhen Hospital, Southern Medical University, Shenzhen, China
Keywords: SARS-CoV-2, adenovirus vectored vaccines, immunization, primates
Summary of Study: Two novel adenovirus vectored COVID-19 vaccines were produced, which, when used in succession, elicited robust humoral and T-cell immune response to SARS-CoV-2 in mice and rhesus macaques. These two vaccines are being planned for clinical phase I/II trials after an extensive safety evaluation has been carried out in pre-clinical animal examination.
References: doi: https://doi.org/10.1101/2020.09.28.311480
Contact Info: Chengyao Li: chengyaoli@hotmail.com; Tingting L: aple-ting-007@163.com
URL: https://www.biorxiv.org/content/10.1101/2020.09.28.311480v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: University of Texas Medical Branch, Galveston
Keywords: SARS-CoV-2, apoptosis in post-mortem lung, pathogenesis, primates
Summary of Study: Apoptosis was examined in post-mortem lung sections from COVID-19 patients and lung tissues from NHP models of SARS-CoV-2 infection. Multiple-target immunofluorescence assays and Western blotting suggest both intrinsic and extrinsic apoptotic pathways are activated during SARS-CoV-2 infection. These findings may help to delineate a novel insight into the pathogenesis of ARDS following SARS-CoV-2 infection.
References: PMID: 33398280/doi: 10.1101/2020.12.23.424254
Contact Info: Bin Gong: bigong@utmb.edu
URL: https://www.biorxiv.org/content/10.1101/2020.12.23.424254v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: University of Texas Medical Branch, Galveston
Keywords: SARS-CoV-2, apoptosis in post-mortem lung, pathogenesis, primates
Summary of Study: Apoptosis was examined in post-mortem lung sections from COVID-19 patients and lung tissues from NHP models of SARS-CoV-2 infection. Multiple-target immunofluorescence assays and Western blotting suggest both intrinsic and extrinsic apoptotic pathways are activated during SARS-CoV-2 infection. These findings may help to delineate a novel insight into the pathogenesis of ARDS following SARS-CoV-2 infection.
References: PMID: 33398280/doi: 10.1101/2020.12.23.424254
Contact Info: Bin Gong: bigong@utmb.edu
URL: https://www.biorxiv.org/content/10.1101/2020.12.23.424254v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: nanogen Pharmaceutical Biotechnology JSC
Keywords: SARS-CoV-2, vaccine candidate, receptor-binding domain, immune response, hamsters, mice, primates
Summary of Study: Nanocovax, a vaccine candidate based on recombinant protein production of the extracellular (soluble) portion of the S protein of SARS-CoV-2, induced high levels of S protein-specific IgG, as well as neutralizing antibody in three animal models (mice, Syrian hamsters, and Macaca leonina (Northern pig-tailed macaque).
References: doi: 10.1101/2021.07.20.453162
Contact Info: Do Minh Si: minhsi@nanogenpharma.com
URL: https://www.biorxiv.org/content/10.1101/2021.07.20.453162v1
NHP Species: pigtail macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: nanogen Pharmaceutical Biotechnology JSC
Keywords: SARS-CoV-2, vaccine candidate, receptor-binding domain, immune response, hamsters, mice, primates
Summary of Study: Nanocovax, a vaccine candidate based on recombinant protein production of the extracellular (soluble) portion of the S protein of SARS-CoV-2, induced high levels of S protein-specific IgG, as well as neutralizing antibody in three animal models (mice, Syrian hamsters, and Macaca leonina (Northern pig-tailed macaque).
References: doi: 10.1101/2021.07.20.453162
Contact Info: Do Minh Si: minhsi@nanogenpharma.com
URL: https://www.biorxiv.org/content/10.1101/2021.07.20.453162v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID, Emory University, Moderna
Keywords: SARS-CoV-2, mRNA vaccine, immune response, pathology, primates
Summary of Study: Immunization with two doses of mRNA-1273 achieves effective immunity that rapidly controls lower and upper airway viral replication against the B.1.351 variant in NHP.
References: doi: 10.1101/2021.05.21.445189
Contact Info: Barney Graham: bgraham@nih.gov; Robert Seder: rseder@mail.nih.gov;
URL: https://www.biorxiv.org/content/10.1101/2021.05.21.445189v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID, Emory University, Moderna
Keywords: SARS-CoV-2, mRNA vaccine, immune response, pathology, primates
Summary of Study: Immunization with two doses of mRNA-1273 achieves effective immunity that rapidly controls lower and upper airway viral replication against the B.1.351 variant in NHP.
References: doi: 10.1101/2021.05.21.445189
Contact Info: Barney Graham: bgraham@nih.gov; Robert Seder: rseder@mail.nih.gov;
URL: https://www.biorxiv.org/content/10.1101/2021.05.21.445189v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: MIT, Harvard Medical School, Vaccine Analytics and Formulation Center (Univ. of Kansas), Cummings School of Veterinary Medicine (Tufts Univ.), SpyBiotech Ltd., Bioqual, Bill & Melinda Gates Fdtn.
Keywords: SARS-CoV-2, protein subunit vaccine, manufacturing, preclinical testing, primates
Summary of Study: A modular protein subunit vaccine candidate elicits a strong immune response in cynomolgus macaques and protects against SARS-CoV-2 challenge. This vaccine candidate is currently being tested in clinical trials (ANZCTR Registration number ACTRN12620000817943).
References: PMID: 34282417 / doi: 10.1101/2021.07.13.452251
Contact Info: Dan Barouch: abarouch@bidmc.harvard.edu; J. Christopher Love: clove@mit.edu
URL: https://www.biorxiv.org/content/10.1101/2021.07.13.452251v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: MIT, Harvard Medical School, Vaccine Analytics and Formulation Center (Univ. of Kansas), Cummings School of Veterinary Medicine (Tufts Univ.), SpyBiotech Ltd., Bioqual, Bill & Melinda Gates Fdtn.
Keywords: SARS-CoV-2, protein subunit vaccine, manufacturing, preclinical testing, primates
Summary of Study: A modular protein subunit vaccine candidate elicits a strong immune response in cynomolgus macaques and protects against SARS-CoV-2 challenge. This vaccine candidate is currently being tested in clinical trials (ANZCTR Registration number ACTRN12620000817943).
References: PMID: 34282417 / doi: 10.1101/2021.07.13.452251
Contact Info: Dan Barouch: abarouch@bidmc.harvard.edu; J. Christopher Love: clove@mit.edu
URL: https://www.biorxiv.org/content/10.1101/2021.07.13.452251v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Harvard, MIT, Emory University School of Medicine, Yerkes National Primate Research Center and others
Keywords: SARS-CoV-2, adjuvanted soluble protein vaccine, binding and functional neutralization assays, serology, primates
Summary of Study: Antibodies induced by the AS03-adjuvanted preS dTM vaccine are sufficient to mediate protection against SARS-CoV-2 and support the evaluation of this vaccine in human clinical trials.
References: PMID: 33688652 / doi: 10.1101/2021.03.02.433390
Contact Info: Robert Seder: rseder@mail.nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.03.02.433390v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Harvard, MIT, Emory University School of Medicine, Yerkes National Primate Research Center and others
Keywords: SARS-CoV-2, adjuvanted soluble protein vaccine, binding and functional neutralization assays, serology, primates
Summary of Study: Antibodies induced by the AS03-adjuvanted preS dTM vaccine are sufficient to mediate protection against SARS-CoV-2 and support the evaluation of this vaccine in human clinical trials.
References: PMID: 33688652 / doi: 10.1101/2021.03.02.433390
Contact Info: Robert Seder: rseder@mail.nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.03.02.433390v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: ONPRC/YNPRC
Keywords: SARS-CoV-2, kinase inhibitor, primates
Summary of Study: Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques
References: doi: https://doi.org/10.1101/2020.09.16.300277
Contact Info: Dr. Mirko Paiardini; E-mail address: mirko.paiardini@emory.edu
URL: https://www.biorxiv.org/content/10.1101/2020.09.16.300277v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: ONPRC/YNPRC
Keywords: SARS-CoV-2, kinase inhibitor, primates
Summary of Study: Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques
References: doi: https://doi.org/10.1101/2020.09.16.300277
Contact Info: Dr. Mirko Paiardini; E-mail address: mirko.paiardini@emory.edu
URL: https://www.biorxiv.org/content/10.1101/2020.09.16.300277v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: University of Liverpool; NIHR Health Protection Unit in Emerging and Zoonotic Infections; University of Bristol; IK Health Security Agency; Mahidol University; Alder Hey Children's Hospital; Imperial College London; The Roslin Institute, University of Edinburgh; Royal United Hospitals Bath NHS Foundation Trust; University of Oxford; A*STAR, Singapore.
Keywords: SARS-CoV-2, viral genomic variants, variant prediction, primates
Summary of Study: The selection pressure at two positions (the P323L and the D614G substitutions in the in NSP12 and the spike protein, respectively) was evaluated in two non-human primate models. The data in this study indicates that in some cases it may be possible to predict the emergence of a new dominant viral genome sequence and hence a new variant.
References: doi: 10.1101/2021.12.23.474030
Contact Info: Julian Hiscox: junian.hiscox@liverpool.ac.uk
URL: https://www.biorxiv.org/content/10.1101/2021.12.23.474030v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: University of Liverpool; NIHR Health Protection Unit in Emerging and Zoonotic Infections; University of Bristol; IK Health Security Agency; Mahidol University; Alder Hey Children's Hospital; Imperial College London; The Roslin Institute, University of Edinburgh; Royal United Hospitals Bath NHS Foundation Trust; University of Oxford; A*STAR, Singapore.
Keywords: SARS-CoV-2, viral genomic variants, variant prediction, primates
Summary of Study: The selection pressure at two positions (the P323L and the D614G substitutions in the in NSP12 and the spike protein, respectively) was evaluated in two non-human primate models. The data in this study indicates that in some cases it may be possible to predict the emergence of a new dominant viral genome sequence and hence a new variant.
References: doi: 10.1101/2021.12.23.474030
Contact Info: Julian Hiscox: junian.hiscox@liverpool.ac.uk
URL: https://www.biorxiv.org/content/10.1101/2021.12.23.474030v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: California Institute of Technology; NIAID, Fred Hutchinson Cancer Research Center; Bioqual; University of Oxford; Howard Hughes Medical Institute
Keywords: SARS-CoV-2, spike receptor-binding domains, mosaic nanoparticles, immunogenicity, mice, primates
Summary of Study: A mosaic RBD nanoparticle presenting 8 different sarbecovirus RBDs protected against challenges from both matched and mismatched sarbecoviruses, as compared with homotypic SARS-2 RBD nanoparticles that protected fully only against a matched challenge.
References: PMID: 35378752 / doi: 10.1101/2022.03.25.485875
Contact Info: Pamela Bjorkman: bjorkman@caltech.edu
URL: https://www.biorxiv.org/content/10.1101/2022.03.25.485875v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: California Institute of Technology; NIAID, Fred Hutchinson Cancer Research Center; Bioqual; University of Oxford; Howard Hughes Medical Institute
Keywords: SARS-CoV-2, spike receptor-binding domains, mosaic nanoparticles, immunogenicity, mice, primates
Summary of Study: A mosaic RBD nanoparticle presenting 8 different sarbecovirus RBDs protected against challenges from both matched and mismatched sarbecoviruses, as compared with homotypic SARS-2 RBD nanoparticles that protected fully only against a matched challenge.
References: PMID: 35378752 / doi: 10.1101/2022.03.25.485875
Contact Info: Pamela Bjorkman: bjorkman@caltech.edu
URL: https://www.biorxiv.org/content/10.1101/2022.03.25.485875v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: National Institute of Allergy and Infectious Diseases, National Institutes of Health
Keywords: SARS-CoV-2, virus variants, pathology, immune response, primates
Summary of Study: Disease severity among variants is unequal, with a lower viral load and thus reduced clinical disease in Omicron versus Delta variants.
References: PMID: 35971544 / doi: 10.1101/2022.08.01.502390
Contact Info: Neeltje van Doremalen: neeltje.vandoremalen@nih.gov; Kyle Rosenke: kyle.rosenke@nih.gov
URL: https://www.biorxiv.org/content/10.1101/2022.08.01.502390v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: National Institute of Allergy and Infectious Diseases, National Institutes of Health
Keywords: SARS-CoV-2, virus variants, pathology, immune response, primates
Summary of Study: Disease severity among variants is unequal, with a lower viral load and thus reduced clinical disease in Omicron versus Delta variants.
References: PMID: 35971544 / doi: 10.1101/2022.08.01.502390
Contact Info: Neeltje van Doremalen: neeltje.vandoremalen@nih.gov; Kyle Rosenke: kyle.rosenke@nih.gov
URL: https://www.biorxiv.org/content/10.1101/2022.08.01.502390v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Sarafan ChEM-H, Stanford University, Stanford, CA; Department of Chemistry, Stanford University, Stanford, CA; Department of Biochemistry, School of Medicine, Stanford University, Stanford, CA; others
Keywords: SARS-CoV-2, ferritin-based, protein-nanoparticle vaccine, immune response, booster, primates
Summary of Study: A ferritin-based COVID-19 nanoparticle vaccine
References: doi: 10.1101/2022.12.25.521784
Contact Info: Peter S Kim: kimpeter@stanford.edu
URL: https://www.biorxiv.org/content/10.1101/2022.12.25.521784v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Sarafan ChEM-H, Stanford University, Stanford, CA; Department of Chemistry, Stanford University, Stanford, CA; Department of Biochemistry, School of Medicine, Stanford University, Stanford, CA; others
Keywords: SARS-CoV-2, ferritin-based, protein-nanoparticle vaccine, immune response, booster, primates
Summary of Study: A ferritin-based COVID-19 nanoparticle vaccine
References: doi: 10.1101/2022.12.25.521784
Contact Info: Peter S Kim: kimpeter@stanford.edu
URL: https://www.biorxiv.org/content/10.1101/2022.12.25.521784v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: California National Primate Research Center; University of California, Davis; Vitalant Research Institute; University of California, Irvine School of Medicine; DMID/NIAID/NIH; University of California, San Francisco
Keywords: SARS-CoV-2, convalescent plasma, immune response, pathology, primates
Summary of Study: While administration of CCP did not result in a detectable reduction in virus replication in the respiratory tract, it significantly reduced lung inflammation. in macaques infected with SARS-CoV-2.
References: PMID: 34494025 / doi: 10.1101/2021.09.01.458520
Contact Info: Koen Van Rompay: kkvanrompay@ucdavis.edu; Rachel Reader: rreader@ucdavis.edu; Michael Busch: mbusch@vitalant.org
URL: https://www.biorxiv.org/content/10.1101/2021.09.01.458520v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: California National Primate Research Center; University of California, Davis; Vitalant Research Institute; University of California, Irvine School of Medicine; DMID/NIAID/NIH; University of California, San Francisco
Keywords: SARS-CoV-2, convalescent plasma, immune response, pathology, primates
Summary of Study: While administration of CCP did not result in a detectable reduction in virus replication in the respiratory tract, it significantly reduced lung inflammation. in macaques infected with SARS-CoV-2.
References: PMID: 34494025 / doi: 10.1101/2021.09.01.458520
Contact Info: Koen Van Rompay: kkvanrompay@ucdavis.edu; Rachel Reader: rreader@ucdavis.edu; Michael Busch: mbusch@vitalant.org
URL: https://www.biorxiv.org/content/10.1101/2021.09.01.458520v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Washington National Primate Research Center; North Carolina State University College of Veterinary Medicine; University of Washington.
Keywords: SARS-CoV-2, single cell immune repertoire profiling, gene expression, primates
Summary of Study: Results establish the ability to perform high throughput scIRS analyusis in rhesus macaques with comparable performances to commercially available platforms.
References: doi: 10.1101/2021.08.17.456682
Contact Info: Xinxia Peng: xpeng5@ncsu.edu
URL: https://www.biorxiv.org/content/10.1101/2021.08.17.456682v1.supplementary-mater…
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Washington National Primate Research Center; North Carolina State University College of Veterinary Medicine; University of Washington.
Keywords: SARS-CoV-2, single cell immune repertoire profiling, gene expression, primates
Summary of Study: Results establish the ability to perform high throughput scIRS analyusis in rhesus macaques with comparable performances to commercially available platforms.
References: doi: 10.1101/2021.08.17.456682
Contact Info: Xinxia Peng: xpeng5@ncsu.edu
URL: https://www.biorxiv.org/content/10.1101/2021.08.17.456682v1.supplementary-mater…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; Henan Normal University; Guangzhou Medical University; Fudan University
Keywords: SARS-CoV-2, inflammation, lung pathology, immune response, primates
Summary of Study: SARS-CoV-2 triggers an immediate mast cell (MC) degranulation, which initiates the alveolar epithelial inflammation and disrupts the tight junction. MC stabilizers that block degranulation reduce virus-induced lung inflammation and injury.
References: doi: 10.1101/2021.06.24.449680
Contact Info: Jian-Hua Wang: wang_jianhua@gibh.ac.cn
URL: https://www.biorxiv.org/content/10.1101/2021.06.24.449680v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; Henan Normal University; Guangzhou Medical University; Fudan University
Keywords: SARS-CoV-2, inflammation, lung pathology, immune response, primates
Summary of Study: SARS-CoV-2 triggers an immediate mast cell (MC) degranulation, which initiates the alveolar epithelial inflammation and disrupts the tight junction. MC stabilizers that block degranulation reduce virus-induced lung inflammation and injury.
References: doi: 10.1101/2021.06.24.449680
Contact Info: Jian-Hua Wang: wang_jianhua@gibh.ac.cn
URL: https://www.biorxiv.org/content/10.1101/2021.06.24.449680v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: University of Liverpool, Public Health England, University of Bristol, and others
Keywords: SARS-CoV-2, the leader-transcriptional regulatory sequence gene junction, high resolution sequencing, primates
Summary of Study: LeTRS, a bioinformatics tool, identified known leader-TRS-junctions and identified novel species that were common across different species. The data indicated multi-phasic abundance of sgmRNAs in two different NHP models, with spikes in sgmRNA abundance reflected in human samples, and therefore has implications for transmission models and nucleic acid-based diagnostics.
References: doi: 10.1101/2021.03.03.433753
Contact Info: Julian Hiscox: julian.hiscox@liverpool.ac.uk
URL: https://www.biorxiv.org/content/10.1101/2021.03.03.433753v2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: University of Liverpool, Public Health England, University of Bristol, and others
Keywords: SARS-CoV-2, the leader-transcriptional regulatory sequence gene junction, high resolution sequencing, primates
Summary of Study: LeTRS, a bioinformatics tool, identified known leader-TRS-junctions and identified novel species that were common across different species. The data indicated multi-phasic abundance of sgmRNAs in two different NHP models, with spikes in sgmRNA abundance reflected in human samples, and therefore has implications for transmission models and nucleic acid-based diagnostics.
References: doi: 10.1101/2021.03.03.433753
Contact Info: Julian Hiscox: julian.hiscox@liverpool.ac.uk
URL: https://www.biorxiv.org/content/10.1101/2021.03.03.433753v2
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: SL VaxiGen Inc., Genexine Inc., Sorea Bio Park, Scongnam, Republic of Korea
Keywords: SARS-CoV-2, DNA-based vaccine candidate, GX-19, immunization, primates
Summary of Study: Vaccination with vaccine candidate GX-19 elicits a concurrent humoral response and Th1-biased immune responses in both mice and non-human primate models. In NHPs this response includes neutralizing antibodies that provide potent protective efficacy against SARS-CoV-2 infection.
References: doi: https://doi.org/10.1101/2020.10.09.334136
Contact Info: Young Chul Sung: ycsung@genexine.com
URL: https://www.biorxiv.org/content/10.1101/2020.10.09.334136v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: SL VaxiGen Inc., Genexine Inc., Sorea Bio Park, Scongnam, Republic of Korea
Keywords: SARS-CoV-2, DNA-based vaccine candidate, GX-19, immunization, primates
Summary of Study: Vaccination with vaccine candidate GX-19 elicits a concurrent humoral response and Th1-biased immune responses in both mice and non-human primate models. In NHPs this response includes neutralizing antibodies that provide potent protective efficacy against SARS-CoV-2 infection.
References: doi: https://doi.org/10.1101/2020.10.09.334136
Contact Info: Young Chul Sung: ycsung@genexine.com
URL: https://www.biorxiv.org/content/10.1101/2020.10.09.334136v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Eli Lilly & Co.; NIAID
Keywords: SARS-CoV-2, anti-spike neutralizing antibodies, primate challenge model
Summary of Study: Prophylactic treatment with LY-CoV555 (a neutralizing antibody) resulted in significant decreases in viral load (gRNA) and viral replication (sgRNA) in the lower respiratory tract of rhesus macaques following SARS-CoV2 inoculation, based on determination in BAL and lung tissue.
References: doi:Â https://doi.org/10.1101/2020.09.30.318972
Contact Info: Bryan Jones: jones_bryan_edward@lilly.com; Ester Falconer: ester.falconer@abcellera.com
URL: https://www.biorxiv.org/content/10.1101/2020.09.30.318972v3
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Eli Lilly & Co.; NIAID
Keywords: SARS-CoV-2, anti-spike neutralizing antibodies, primate challenge model
Summary of Study: Prophylactic treatment with LY-CoV555 (a neutralizing antibody) resulted in significant decreases in viral load (gRNA) and viral replication (sgRNA) in the lower respiratory tract of rhesus macaques following SARS-CoV2 inoculation, based on determination in BAL and lung tissue.
References: doi:Â https://doi.org/10.1101/2020.09.30.318972
Contact Info: Bryan Jones: jones_bryan_edward@lilly.com; Ester Falconer: ester.falconer@abcellera.com
URL: https://www.biorxiv.org/content/10.1101/2020.09.30.318972v3
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: NIAID/NIH
Keywords: SARS-CoV-2, virus variants, pathogenicity, immune response, primates
Summary of Study: A side-by-side comparison of three SARS-CoV-2 varients sugests that ongoing circulation under diverse evolutionary pressures favors transmissibility and immune evasion rather than an increase in intrinsic pathogenicity.
References: PMID: 34382034 / doi: 10.1101/2021.05.07.443115
Contact Info: Emmie de Wit: emmie.dewit@nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.05.07.443115v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: NIAID/NIH
Keywords: SARS-CoV-2, virus variants, pathogenicity, immune response, primates
Summary of Study: A side-by-side comparison of three SARS-CoV-2 varients sugests that ongoing circulation under diverse evolutionary pressures favors transmissibility and immune evasion rather than an increase in intrinsic pathogenicity.
References: PMID: 34382034 / doi: 10.1101/2021.05.07.443115
Contact Info: Emmie de Wit: emmie.dewit@nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.05.07.443115v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Harvard Medical School; Walter Reed National Military Medical Center; Ragon Institute of MGH, MIT and Harvard; Bioqual; University of Pittsburgh; Henry Jackson Foundation
Keywords: SARS-CoV-2, live oral vaccine, immune response, pathology, primates
Summary of Study: Post-pyloric inoculation of live SARS-CoV-2 is weakly immunogenic and confers partial protection against respiratory SARS-CoV-2 challenge in rhesus macaques.
References: doi: 10.1101/2021.09.13.460191
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.biorxiv.org/content/10.1101/2021.09.13.460191v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Harvard Medical School; Walter Reed National Military Medical Center; Ragon Institute of MGH, MIT and Harvard; Bioqual; University of Pittsburgh; Henry Jackson Foundation
Keywords: SARS-CoV-2, live oral vaccine, immune response, pathology, primates
Summary of Study: Post-pyloric inoculation of live SARS-CoV-2 is weakly immunogenic and confers partial protection against respiratory SARS-CoV-2 challenge in rhesus macaques.
References: doi: 10.1101/2021.09.13.460191
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://www.biorxiv.org/content/10.1101/2021.09.13.460191v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Yerkes National Primate Research Center, Emory University; Emory University School of Medicine; University of Pittsburgh
Keywords: SARS-CoV-2, multi-omic analyses, inflammation, immune response, primates
Summary of Study: Multi-omic analyses of hyperacute SARS-CoV-2 infection in rhesus macaques identified two populations of infiltrating macrophages as the primary orchestrators of inflammation in th elowre airway that can be successfully treated with baricitinib.
References: PMID: 34642693 / doi: 10.1101/2021.10.05.463212
Contact Info: Steven Bosinger: steven.bosinger@emory.edu; Mirko Paiardini: mirko.paiardini@emory.edu
URL: https://www.biorxiv.org/content/10.1101/2021.10.05.463212v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Yerkes National Primate Research Center, Emory University; Emory University School of Medicine; University of Pittsburgh
Keywords: SARS-CoV-2, multi-omic analyses, inflammation, immune response, primates
Summary of Study: Multi-omic analyses of hyperacute SARS-CoV-2 infection in rhesus macaques identified two populations of infiltrating macrophages as the primary orchestrators of inflammation in th elowre airway that can be successfully treated with baricitinib.
References: PMID: 34642693 / doi: 10.1101/2021.10.05.463212
Contact Info: Steven Bosinger: steven.bosinger@emory.edu; Mirko Paiardini: mirko.paiardini@emory.edu
URL: https://www.biorxiv.org/content/10.1101/2021.10.05.463212v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Pasteur Institute of Iran; University of Tehran; Biosunpharmed Co, Tehran; and others
Keywords: SARS-CoV-2, inactivated whole-virus vaccine, immune response, mice, guinea pig, rabbit and primates
Summary of Study: COVIran Barekat, an inactivated whole-virus SARS-CoV-2 candidate vaccine, elicited a high level of SARS-CoV-2 specific neutralizing antibodies in mice, rabbits, and rhesus macaques.
References: doi: 10.1101/2021.06.10.44.447951
Contact Info: Reza Aalizadeh: allizadehreza19@gmail.com; Hasan Jalili: hjalili@ut.ac.ir
URL: https://www.biorxiv.org/content/10.1101/2021.06.10.447951v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Pasteur Institute of Iran; University of Tehran; Biosunpharmed Co, Tehran; and others
Keywords: SARS-CoV-2, inactivated whole-virus vaccine, immune response, mice, guinea pig, rabbit and primates
Summary of Study: COVIran Barekat, an inactivated whole-virus SARS-CoV-2 candidate vaccine, elicited a high level of SARS-CoV-2 specific neutralizing antibodies in mice, rabbits, and rhesus macaques.
References: doi: 10.1101/2021.06.10.44.447951
Contact Info: Reza Aalizadeh: allizadehreza19@gmail.com; Hasan Jalili: hjalili@ut.ac.ir
URL: https://www.biorxiv.org/content/10.1101/2021.06.10.447951v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: ReiThera Sri, Rome, Italy; The University of Nottingham
Keywords: SARS-CoV-2, gorilla adenovirus-vectored vaccine, primates
Summary of Study: Vaccine candidate, GRAd-COV2, is highly immunogenic in both mice and cynomolgus macaques, eliciting both functional antibodies which neutralize SARS-CoV-2 infection and block Spike protein binding to the ACE2 receptor, and a robust, Th1-dominated cellular response in the periphery and in the lung.
References: doi: https://doi.org/10.1101/2020.10.22.349951
Contact Info: Alessandra Vitelli: alessandra.vitelli@reithera.com
URL: https://www.biorxiv.org/content/10.1101/2020.10.22.349951v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: ReiThera Sri, Rome, Italy; The University of Nottingham
Keywords: SARS-CoV-2, gorilla adenovirus-vectored vaccine, primates
Summary of Study: Vaccine candidate, GRAd-COV2, is highly immunogenic in both mice and cynomolgus macaques, eliciting both functional antibodies which neutralize SARS-CoV-2 infection and block Spike protein binding to the ACE2 receptor, and a robust, Th1-dominated cellular response in the periphery and in the lung.
References: doi: https://doi.org/10.1101/2020.10.22.349951
Contact Info: Alessandra Vitelli: alessandra.vitelli@reithera.com
URL: https://www.biorxiv.org/content/10.1101/2020.10.22.349951v1