Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV
NHP Species:
Year Published: 2007
Study Type/Review:
NPRC/Institute: NIH R01 grant HL080621-01A1, European Union grant SP-22-CT-2004–511060
Keywords: SARS-CoV, SARS, interleukin, interferon
Summary of Study: The induction of early IFN signaling may be critical to confer protection against SARS-CoV infection in cynomolgus macaques.
References: doi: 10.1371/journal.ppat.0030112; PMID: 17696609; PMCID: PMC1941749
Contact Info: de Lang A, et al.; correspondence to Bart Haagmans ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/17696609/
NHP Species:
Year Published: 2007
Study Type/Review:
NPRC/Institute: NIH R01 grant HL080621-01A1, European Union grant SP-22-CT-2004–511060
Keywords: SARS-CoV, SARS, interleukin, interferon
Summary of Study: The induction of early IFN signaling may be critical to confer protection against SARS-CoV infection in cynomolgus macaques.
References: doi: 10.1371/journal.ppat.0030112; PMID: 17696609; PMCID: PMC1941749
Contact Info: de Lang A, et al.; correspondence to Bart Haagmans ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/17696609/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2007
Study Type/Review:
NPRC/Institute: Medicine Foundation of China
Keywords: SARS-CoV, animal model, macaca rhesus
Summary of Study: Rhesus macaques infected with SARS-CoV developed the typical SARS according to clinical, virological, and pathological findings.
References: PMID: 18076307
Contact Info: Luo F, et al.; correspondence to David Hou ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/18076307/
NHP Species: rhesus macaques
Year Published: 2007
Study Type/Review:
NPRC/Institute: Medicine Foundation of China
Keywords: SARS-CoV, animal model, macaca rhesus
Summary of Study: Rhesus macaques infected with SARS-CoV developed the typical SARS according to clinical, virological, and pathological findings.
References: PMID: 18076307
Contact Info: Luo F, et al.; correspondence to David Hou ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/18076307/
Coronavirus Investigated: SARS-CoV
NHP Species:
Year Published: 2007
Study Type/Review:
NPRC/Institute: Research on Emerging and Re-emerging Infectious Diseases from the Ministry of Health, Labour and Welfare, Japan
Keywords: animal model, coronavirus, cynomolgus monkey, pathogenesis, SARS-CoV
Summary of Study: SARS-CoV appears to spread into and perhaps via the intestinal and lymphatic systems of cynomolgus macaques.
References: doi: 10.1111/j.1365-2613.2007.00567.x; PMID: 18039277; PMCID: PMC2517337
Contact Info: Nagata N, et al.; correspondence to Noriyo Nagata ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/18039277/
NHP Species:
Year Published: 2007
Study Type/Review:
NPRC/Institute: Research on Emerging and Re-emerging Infectious Diseases from the Ministry of Health, Labour and Welfare, Japan
Keywords: animal model, coronavirus, cynomolgus monkey, pathogenesis, SARS-CoV
Summary of Study: SARS-CoV appears to spread into and perhaps via the intestinal and lymphatic systems of cynomolgus macaques.
References: doi: 10.1111/j.1365-2613.2007.00567.x; PMID: 18039277; PMCID: PMC2517337
Contact Info: Nagata N, et al.; correspondence to Noriyo Nagata ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/18039277/
Coronavirus Investigated: SARS-CoV
NHP Species: Formosan macaques
Year Published: 2006
Study Type/Review:
NPRC/Institute: National Health Research, Taiwan
Keywords: SARS-CoV, epitopes, vaccine, nucleocapsid protein
Summary of Study: This study identified immune responses of mice, monkeys, and humans to the rN protein of the coronavirus. Their findings indicate “immunodominant B-cell and T-cell epitopes†are conserved across these three species.
References: doi: 10.1016/j.vaccine.2006.01.058
Contact Info: Liu SJ, et al.; correspondence to Pele Chong ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16494977/
NHP Species: Formosan macaques
Year Published: 2006
Study Type/Review:
NPRC/Institute: National Health Research, Taiwan
Keywords: SARS-CoV, epitopes, vaccine, nucleocapsid protein
Summary of Study: This study identified immune responses of mice, monkeys, and humans to the rN protein of the coronavirus. Their findings indicate “immunodominant B-cell and T-cell epitopes†are conserved across these three species.
References: doi: 10.1016/j.vaccine.2006.01.058
Contact Info: Liu SJ, et al.; correspondence to Pele Chong ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16494977/
Coronavirus Investigated: SARS-CoV
NHP Species:
Year Published: 2006
Study Type/Review: vaccine
NPRC/Institute: National High Technology Research and Development Program of China (No. 2003AA208201)
Keywords: SARS, SARS-CoV, inactivated vaccine, monkey
Summary of Study: Young adult male macaques were immunized with an adjuvant-containing purified vaccine, purified inactivated SARS vaccine, or an unpurified vaccine and then challenged with SARS-CoV BJ-01 strain. Results indicated the purified vaccine induced high levels of antibodies and prevented the replication of the virus in monkeys.
References: doi: 10.1016/j.vaccine.2005.06.038
Contact Info: Qin E, et al.; correspondence to Ede Qin ([email protected]) and Qingyu Zhu ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16388880/
NHP Species:
Year Published: 2006
Study Type/Review: vaccine
NPRC/Institute: National High Technology Research and Development Program of China (No. 2003AA208201)
Keywords: SARS, SARS-CoV, inactivated vaccine, monkey
Summary of Study: Young adult male macaques were immunized with an adjuvant-containing purified vaccine, purified inactivated SARS vaccine, or an unpurified vaccine and then challenged with SARS-CoV BJ-01 strain. Results indicated the purified vaccine induced high levels of antibodies and prevented the replication of the virus in monkeys.
References: doi: 10.1016/j.vaccine.2005.06.038
Contact Info: Qin E, et al.; correspondence to Ede Qin ([email protected]) and Qingyu Zhu ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16388880/
Coronavirus Investigated: SARS-CoV
NHP Species: chimpanzees
Year Published: 2006
Study Type/Review:
NPRC/Institute: GlaxoSmithKline Pharmaceuticals
Keywords: AdH5, neutralizing antibodies, SARS-CoV, AdC7
Summary of Study: Findings warrant the further development of AdC7 as a vaccine carrier for SARS-CoV treatments in human trials.
References: doi: 10.1089/hum.2006.17.500; PMID: 16716107
Contact Info: Zhi Y, et al.; correspondence to James M. Wilson ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16716107/
NHP Species: chimpanzees
Year Published: 2006
Study Type/Review:
NPRC/Institute: GlaxoSmithKline Pharmaceuticals
Keywords: AdH5, neutralizing antibodies, SARS-CoV, AdC7
Summary of Study: Findings warrant the further development of AdC7 as a vaccine carrier for SARS-CoV treatments in human trials.
References: doi: 10.1089/hum.2006.17.500; PMID: 16716107
Contact Info: Zhi Y, et al.; correspondence to James M. Wilson ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16716107/
Coronavirus Investigated: SARS-CoV
NHP Species:
Year Published: 2006
Study Type/Review:
NPRC/Institute: USAMRIID
Keywords: SARS-CoV, nonhuman primate, SARS
Summary of Study: Cynomolgus macaques were infected with SARS-CoV. Symptoms similar to mild SARS-CoV characteristically seen in children were observed.
References: doi: 10.1371/journal.pmed.0030149; PMID: 16605302
Contact Info: Lawler JV, et al.; correspondence to Jason Paragas ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16605302/
NHP Species:
Year Published: 2006
Study Type/Review:
NPRC/Institute: USAMRIID
Keywords: SARS-CoV, nonhuman primate, SARS
Summary of Study: Cynomolgus macaques were infected with SARS-CoV. Symptoms similar to mild SARS-CoV characteristically seen in children were observed.
References: doi: 10.1371/journal.pmed.0030149; PMID: 16605302
Contact Info: Lawler JV, et al.; correspondence to Jason Paragas ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16605302/
Coronavirus Investigated: SARS-CoV
NHP Species:
Year Published: 2006
Study Type/Review:
NPRC/Institute: Department of Virology, Erasmus Medical Center, Rotterdam, Netherlands
Keywords: SARS, pathogenesis, nonhuman primate
Summary of Study: Synopsis of findings from animal models of SARS-CoV with an emphasis on nonhuman primates.
References: doi: 10.1371/journal.pmed.0030194
Contact Info: Haagman BL and Osterhaus A; correspondence to Albert Osterhaus ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16608385/
NHP Species:
Year Published: 2006
Study Type/Review:
NPRC/Institute: Department of Virology, Erasmus Medical Center, Rotterdam, Netherlands
Keywords: SARS, pathogenesis, nonhuman primate
Summary of Study: Synopsis of findings from animal models of SARS-CoV with an emphasis on nonhuman primates.
References: doi: 10.1371/journal.pmed.0030194
Contact Info: Haagman BL and Osterhaus A; correspondence to Albert Osterhaus ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16608385/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2006
Study Type/Review:
NPRC/Institute: University of Hong Kong
Keywords: SARS-associated coronavirus, viral kinetics, RNAi, siRNA, inhibition of SCoV reproduction
Summary of Study: Antiviral kinetics of siRNAs targeting structural genes of SARS-CoV in monkey kidney cells indicate that siRNAs targeting specifically replicase, spike protein, envelope protein, and membrane protein could be effective for inhibiting viral replication and infection.
References: doi: 10.1016/j.febslet.2006.03.066
Contact Info: He ML, et al.; correspondence to Hsiang-fu Kung ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16638566/
NHP Species: rhesus macaques
Year Published: 2006
Study Type/Review:
NPRC/Institute: University of Hong Kong
Keywords: SARS-associated coronavirus, viral kinetics, RNAi, siRNA, inhibition of SCoV reproduction
Summary of Study: Antiviral kinetics of siRNAs targeting structural genes of SARS-CoV in monkey kidney cells indicate that siRNAs targeting specifically replicase, spike protein, envelope protein, and membrane protein could be effective for inhibiting viral replication and infection.
References: doi: 10.1016/j.febslet.2006.03.066
Contact Info: He ML, et al.; correspondence to Hsiang-fu Kung ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16638566/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques, pigtail macaques
Year Published: 2006
Study Type/Review:
NPRC/Institute: Yerkes NPRC NIH Base Grant RR00165
Keywords: adenovirus, coronavirus, enterovirus, norovirus, picobirnavirus, rotavirus
Summary of Study: Coronaviruses and other pathogens found in fecal specimens of rhesus, cynomolgus, and pigtail macaques may allow development of better diagnostics for these agents and determine which are clearly associated with gastroenteritis in monkeys.
References: doi: 10.1111/j.1600-0684.2006.00167.x; PMID: 17493140; PMCID: PMC7166873
Contact Info: Wang Y, et al.; correspondence to Baoming Jiang ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/17493140/
NHP Species: rhesus macaques, pigtail macaques
Year Published: 2006
Study Type/Review:
NPRC/Institute: Yerkes NPRC NIH Base Grant RR00165
Keywords: adenovirus, coronavirus, enterovirus, norovirus, picobirnavirus, rotavirus
Summary of Study: Coronaviruses and other pathogens found in fecal specimens of rhesus, cynomolgus, and pigtail macaques may allow development of better diagnostics for these agents and determine which are clearly associated with gastroenteritis in monkeys.
References: doi: 10.1111/j.1600-0684.2006.00167.x; PMID: 17493140; PMCID: PMC7166873
Contact Info: Wang Y, et al.; correspondence to Baoming Jiang ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/17493140/
Coronavirus Investigated: SARS-CoV
NHP Species: Formosan macaques
Year Published: 2006
Study Type/Review:
NPRC/Institute: National Health Research, Taiwan
Keywords: SARS-CoV, epitopes, vaccine, nucleocapsid protein
Summary of Study: This study identified immune responses of mice, monkeys, and humans to the rN protein of the coronavirus. Their findings indicate “immunodominant B-cell and T-cell epitopes†are conserved across these three species.
References: doi: 10.1016/j.vaccine.2006.01.058
Contact Info: Liu SJ, et al.; correspondence to Pele Chong ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16494977/
NHP Species: Formosan macaques
Year Published: 2006
Study Type/Review:
NPRC/Institute: National Health Research, Taiwan
Keywords: SARS-CoV, epitopes, vaccine, nucleocapsid protein
Summary of Study: This study identified immune responses of mice, monkeys, and humans to the rN protein of the coronavirus. Their findings indicate “immunodominant B-cell and T-cell epitopes†are conserved across these three species.
References: doi: 10.1016/j.vaccine.2006.01.058
Contact Info: Liu SJ, et al.; correspondence to Pele Chong ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16494977/
Coronavirus Investigated: SARS-CoV
NHP Species:
Year Published: 2006
Study Type/Review: vaccine
NPRC/Institute: National High Technology Research and Development Program of China (No. 2003AA208201)
Keywords: SARS, SARS-CoV, inactivated vaccine, monkey
Summary of Study: Young adult male macaques were immunized with an adjuvant-containing purified vaccine, purified inactivated SARS vaccine, or an unpurified vaccine and then challenged with SARS-CoV BJ-01 strain. Results indicated the purified vaccine induced high levels of antibodies and prevented the replication of the virus in monkeys.
References: doi: 10.1016/j.vaccine.2005.06.038
Contact Info: Qin E, et al.; correspondence to Ede Qin ([email protected]) and Qingyu Zhu ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16388880/
NHP Species:
Year Published: 2006
Study Type/Review: vaccine
NPRC/Institute: National High Technology Research and Development Program of China (No. 2003AA208201)
Keywords: SARS, SARS-CoV, inactivated vaccine, monkey
Summary of Study: Young adult male macaques were immunized with an adjuvant-containing purified vaccine, purified inactivated SARS vaccine, or an unpurified vaccine and then challenged with SARS-CoV BJ-01 strain. Results indicated the purified vaccine induced high levels of antibodies and prevented the replication of the virus in monkeys.
References: doi: 10.1016/j.vaccine.2005.06.038
Contact Info: Qin E, et al.; correspondence to Ede Qin ([email protected]) and Qingyu Zhu ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16388880/
Coronavirus Investigated: SARS-CoV
NHP Species: chimpanzees
Year Published: 2006
Study Type/Review:
NPRC/Institute: GlaxoSmithKline Pharmaceuticals
Keywords: AdH5, neutralizing antibodies, SARS-CoV, AdC7
Summary of Study: Findings warrant the further development of AdC7 as a vaccine carrier for SARS-CoV treatments in human trials.
References: doi: 10.1089/hum.2006.17.500; PMID: 16716107
Contact Info: Zhi Y, et al.; correspondence to James M. Wilson ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16716107/
NHP Species: chimpanzees
Year Published: 2006
Study Type/Review:
NPRC/Institute: GlaxoSmithKline Pharmaceuticals
Keywords: AdH5, neutralizing antibodies, SARS-CoV, AdC7
Summary of Study: Findings warrant the further development of AdC7 as a vaccine carrier for SARS-CoV treatments in human trials.
References: doi: 10.1089/hum.2006.17.500; PMID: 16716107
Contact Info: Zhi Y, et al.; correspondence to James M. Wilson ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16716107/
Coronavirus Investigated: SARS-CoV
NHP Species:
Year Published: 2006
Study Type/Review:
NPRC/Institute: USAMRIID
Keywords: SARS-CoV, nonhuman primate, SARS
Summary of Study: Cynomolgus macaques were infected with SARS-CoV. Symptoms similar to mild SARS-CoV characteristically seen in children were observed.
References: doi: 10.1371/journal.pmed.0030149; PMID: 16605302
Contact Info: Lawler JV, et al.; correspondence to Jason Paragas ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16605302/
NHP Species:
Year Published: 2006
Study Type/Review:
NPRC/Institute: USAMRIID
Keywords: SARS-CoV, nonhuman primate, SARS
Summary of Study: Cynomolgus macaques were infected with SARS-CoV. Symptoms similar to mild SARS-CoV characteristically seen in children were observed.
References: doi: 10.1371/journal.pmed.0030149; PMID: 16605302
Contact Info: Lawler JV, et al.; correspondence to Jason Paragas ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16605302/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques, pigtail macaques
Year Published: 2006
Study Type/Review:
NPRC/Institute: Yerkes NPRC NIH Base Grant RR00165
Keywords: adenovirus, coronavirus, enterovirus, norovirus, picobirnavirus, rotavirus
Summary of Study: Coronaviruses and other pathogens found in fecal specimens of rhesus, cynomolgus, and pigtail macaques may allow development of better diagnostics for these agents and determine which are clearly associated with gastroenteritis in monkeys.
References: doi: 10.1111/j.1600-0684.2006.00167.x; PMID: 17493140; PMCID: PMC7166873
Contact Info: Wang Y, et al.; correspondence to Baoming Jiang ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/17493140/
NHP Species: rhesus macaques, pigtail macaques
Year Published: 2006
Study Type/Review:
NPRC/Institute: Yerkes NPRC NIH Base Grant RR00165
Keywords: adenovirus, coronavirus, enterovirus, norovirus, picobirnavirus, rotavirus
Summary of Study: Coronaviruses and other pathogens found in fecal specimens of rhesus, cynomolgus, and pigtail macaques may allow development of better diagnostics for these agents and determine which are clearly associated with gastroenteritis in monkeys.
References: doi: 10.1111/j.1600-0684.2006.00167.x; PMID: 17493140; PMCID: PMC7166873
Contact Info: Wang Y, et al.; correspondence to Baoming Jiang ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/17493140/
Coronavirus Investigated: SARS-CoV
NHP Species:
Year Published: 2006
Study Type/Review:
NPRC/Institute: Department of Virology, Erasmus Medical Center, Rotterdam, Netherlands
Keywords: SARS, pathogenesis, nonhuman primate
Summary of Study: Synopsis of findings from animal models of SARS-CoV with an emphasis on nonhuman primates.
References: doi: 10.1371/journal.pmed.0030194
Contact Info: Haagman BL and Osterhaus A; correspondence to Albert Osterhaus ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16608385/
NHP Species:
Year Published: 2006
Study Type/Review:
NPRC/Institute: Department of Virology, Erasmus Medical Center, Rotterdam, Netherlands
Keywords: SARS, pathogenesis, nonhuman primate
Summary of Study: Synopsis of findings from animal models of SARS-CoV with an emphasis on nonhuman primates.
References: doi: 10.1371/journal.pmed.0030194
Contact Info: Haagman BL and Osterhaus A; correspondence to Albert Osterhaus ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16608385/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2006
Study Type/Review:
NPRC/Institute: University of Hong Kong
Keywords: SARS-associated coronavirus, viral kinetics, RNAi, siRNA, inhibition of SCoV reproduction
Summary of Study: Antiviral kinetics of siRNAs targeting structural genes of SARS-CoV in monkey kidney cells indicate that siRNAs targeting specifically replicase, spike protein, envelope protein, and membrane protein could be effective for inhibiting viral replication and infection.
References: doi: 10.1016/j.febslet.2006.03.066
Contact Info: He ML, et al.; correspondence to Hsiang-fu Kung ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16638566/
NHP Species: rhesus macaques
Year Published: 2006
Study Type/Review:
NPRC/Institute: University of Hong Kong
Keywords: SARS-associated coronavirus, viral kinetics, RNAi, siRNA, inhibition of SCoV reproduction
Summary of Study: Antiviral kinetics of siRNAs targeting structural genes of SARS-CoV in monkey kidney cells indicate that siRNAs targeting specifically replicase, spike protein, envelope protein, and membrane protein could be effective for inhibiting viral replication and infection.
References: doi: 10.1016/j.febslet.2006.03.066
Contact Info: He ML, et al.; correspondence to Hsiang-fu Kung ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16638566/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2005
Study Type/Review:
NPRC/Institute: University of Hong Kong
Keywords: SARS coronavirus, mutation, adaptation, selection
Summary of Study: Authors looked at SARS-CoV isolates from nonhuman primate cells for mutations that could provide insight for interspecies infection and the evolution of the SARS virus.
References: doi: 10.1002/jmv.20379
Contact Info: Poon LLM, et al.; correspondence to Joseph SM Peiris ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/15977248/
NHP Species: rhesus macaques
Year Published: 2005
Study Type/Review:
NPRC/Institute: University of Hong Kong
Keywords: SARS coronavirus, mutation, adaptation, selection
Summary of Study: Authors looked at SARS-CoV isolates from nonhuman primate cells for mutations that could provide insight for interspecies infection and the evolution of the SARS virus.
References: doi: 10.1002/jmv.20379
Contact Info: Poon LLM, et al.; correspondence to Joseph SM Peiris ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/15977248/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2005
Study Type/Review:
NPRC/Institute: NIH grants AI059136, AI059443-01, AI059443; UNC medical alumni endowment fund; Infectious Disease Research Training Grant 5T32AI07151-27
Keywords: SARS-CoV, hACE2, human ciliated airway epithelia
Summary of Study: In vitro infection of human (and to a lesser extent hamster and rhesus monkey) airway tissues revealed hACE2 as the primary receptor for SARS-CoV infection of a model of human ciliated airway epithelium.
References: doi: 10.1128/JVI.79.24.15511-15524.2005
Contact Info: Sims AC, et al.; correspondence to Amy C. Sims ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16306622/
NHP Species: rhesus macaques
Year Published: 2005
Study Type/Review:
NPRC/Institute: NIH grants AI059136, AI059443-01, AI059443; UNC medical alumni endowment fund; Infectious Disease Research Training Grant 5T32AI07151-27
Keywords: SARS-CoV, hACE2, human ciliated airway epithelia
Summary of Study: In vitro infection of human (and to a lesser extent hamster and rhesus monkey) airway tissues revealed hACE2 as the primary receptor for SARS-CoV infection of a model of human ciliated airway epithelium.
References: doi: 10.1128/JVI.79.24.15511-15524.2005
Contact Info: Sims AC, et al.; correspondence to Amy C. Sims ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16306622/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2005
Study Type/Review: vaccine
NPRC/Institute: Chinese Medicine Foundation
Keywords: SARS-CoV, inactivated vaccine, immune response
Summary of Study: Authors evaluated an inactivated vaccine for SARS at different concentrations in rhesus monkeys. The study showed the vaccine was safe and induced mucosal and concomitant humoral immunity in monkeys.
References: doi: 10.1016/j.vaccine.2004.11.075
Contact Info: Zhou J, et al.; correspondence to Zhanqiu Yang ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/15837221/
NHP Species: rhesus macaques
Year Published: 2005
Study Type/Review: vaccine
NPRC/Institute: Chinese Medicine Foundation
Keywords: SARS-CoV, inactivated vaccine, immune response
Summary of Study: Authors evaluated an inactivated vaccine for SARS at different concentrations in rhesus monkeys. The study showed the vaccine was safe and induced mucosal and concomitant humoral immunity in monkeys.
References: doi: 10.1016/j.vaccine.2004.11.075
Contact Info: Zhou J, et al.; correspondence to Zhanqiu Yang ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/15837221/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2005
Study Type/Review: vaccine
NPRC/Institute: Tulane National Primate Research Center, base grant RR00164
Keywords: antibodies, viral, membrane glycoproteins, SARS virus, vaccinia virus, viral envelope proteins
Summary of Study: Administration of a vaccine targeting the S-glycoprotein gene in rhesus macaques resulted in a potent immune response and suggests that this vaccine could be effect in protecting Chinese rhesus macaques from SARS-CoV.
References: doi: 10.1128/JVI.79.5.2678-2688.2005
Contact Info: Chen Z, et al.; correspondence to Zhiwei Chen ([email protected]) and David D. Ho ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/15708987/
NHP Species: rhesus macaques
Year Published: 2005
Study Type/Review: vaccine
NPRC/Institute: Tulane National Primate Research Center, base grant RR00164
Keywords: antibodies, viral, membrane glycoproteins, SARS virus, vaccinia virus, viral envelope proteins
Summary of Study: Administration of a vaccine targeting the S-glycoprotein gene in rhesus macaques resulted in a potent immune response and suggests that this vaccine could be effect in protecting Chinese rhesus macaques from SARS-CoV.
References: doi: 10.1128/JVI.79.5.2678-2688.2005
Contact Info: Chen Z, et al.; correspondence to Zhiwei Chen ([email protected]) and David D. Ho ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/15708987/
Coronavirus Investigated: SARS-CoV
NHP Species: marmosets
Year Published: 2005
Study Type/Review:
NPRC/Institute: University of Massachusetts Medical School
Keywords: SARS, SARS-CoV, pathogenesis
Summary of Study: C. jaccus were intratracheally inoculated with the Urbani strain of SARS-CoV. A variety of symptoms resulted, leading the authors to name the marmoset a promising NHP model for the study of SARS-CoV pathogenesis.
References: doi: 10.1016/S0002-9440(10)62989-6; PMID: 16049331
Contact Info: Greenough T, et al.; correspondence to Thomas Greenough ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16049331/
NHP Species: marmosets
Year Published: 2005
Study Type/Review:
NPRC/Institute: University of Massachusetts Medical School
Keywords: SARS, SARS-CoV, pathogenesis
Summary of Study: C. jaccus were intratracheally inoculated with the Urbani strain of SARS-CoV. A variety of symptoms resulted, leading the authors to name the marmoset a promising NHP model for the study of SARS-CoV pathogenesis.
References: doi: 10.1016/S0002-9440(10)62989-6; PMID: 16049331
Contact Info: Greenough T, et al.; correspondence to Thomas Greenough ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16049331/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2005
Study Type/Review:
NPRC/Institute: Unknown funding
Keywords: SARS, siRNA, RNAi
Summary of Study: Three different treatments significantly reduced the severity of viral-induced SARS symptoms in rhesus macaques.
References: doi: 10.1038/sj.gt.3302682; PMID: 17262907; PMCID: PMC7091734
Contact Info: Chang Z and Hu Z; correspondence to Z. Chang ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/17262907/
NHP Species: rhesus macaques
Year Published: 2005
Study Type/Review:
NPRC/Institute: Unknown funding
Keywords: SARS, siRNA, RNAi
Summary of Study: Three different treatments significantly reduced the severity of viral-induced SARS symptoms in rhesus macaques.
References: doi: 10.1038/sj.gt.3302682; PMID: 17262907; PMCID: PMC7091734
Contact Info: Chang Z and Hu Z; correspondence to Z. Chang ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/17262907/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2005
Study Type/Review:
NPRC/Institute: National High Technology Research and Development Programme of China (863 Programme, Nos 2003AA208201, 2003AA208205, and 2003AA208213); National Nature Science Foundation (No 30340026); National Institutes of Health (AIâ€061318); National Basic Research Programme of China (No 2003CB514109)
Keywords: SARS, coronavirus, animal model, pathology, rhesus monkey
Summary of Study: Authors inoculated eight rhesus macaques with SARS-CoV intranasally and systematically observed their response to the virus. All animals exhibited symptoms and inflammation indicating they are an ideal animal model for vaccine development.
References: doi: 10.1002/path.1769
Contact Info: Qin C, et al.; correspondence to Wei He ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/15892035/
NHP Species: rhesus macaques
Year Published: 2005
Study Type/Review:
NPRC/Institute: National High Technology Research and Development Programme of China (863 Programme, Nos 2003AA208201, 2003AA208205, and 2003AA208213); National Nature Science Foundation (No 30340026); National Institutes of Health (AIâ€061318); National Basic Research Programme of China (No 2003CB514109)
Keywords: SARS, coronavirus, animal model, pathology, rhesus monkey
Summary of Study: Authors inoculated eight rhesus macaques with SARS-CoV intranasally and systematically observed their response to the virus. All animals exhibited symptoms and inflammation indicating they are an ideal animal model for vaccine development.
References: doi: 10.1002/path.1769
Contact Info: Qin C, et al.; correspondence to Wei He ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/15892035/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2005
Study Type/Review:
NPRC/Institute: Science and Technology Commission, Guangdong Provincial Government, Guangzhou Science and Technology Bureau, Guangzhou Economic & Technological Development District, and China World Trade Corporation (Guangzhou), Top Biotech, Ltd. (Hong Kong), China
Keywords: SARS, SARS-CoV, siRNA
Summary of Study: This study evaluated the efficacy of using siRNA inhibitors to treat SARS coronavirus (SCV) in vitro in rhesus macaques. Results indicated the siRNAs were able to alleviate infection and symptoms of SCV and warrant further investigation for development of new therapeutic agents.
References: doi: 10.1038/nm1280
Contact Info: Li B, et al.; correspondence to Nanshan Zhong ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16116432/
NHP Species: rhesus macaques
Year Published: 2005
Study Type/Review:
NPRC/Institute: Science and Technology Commission, Guangdong Provincial Government, Guangzhou Science and Technology Bureau, Guangzhou Economic & Technological Development District, and China World Trade Corporation (Guangzhou), Top Biotech, Ltd. (Hong Kong), China
Keywords: SARS, SARS-CoV, siRNA
Summary of Study: This study evaluated the efficacy of using siRNA inhibitors to treat SARS coronavirus (SCV) in vitro in rhesus macaques. Results indicated the siRNAs were able to alleviate infection and symptoms of SCV and warrant further investigation for development of new therapeutic agents.
References: doi: 10.1038/nm1280
Contact Info: Li B, et al.; correspondence to Nanshan Zhong ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16116432/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2005
Study Type/Review:
NPRC/Institute: NIH grants AI059136, AI059443-01, AI059443; UNC medical alumni endowment fund; Infectious Disease Research Training Grant 5T32AI07151-27
Keywords: SARS-CoV, hACE2, human ciliated airway epithelia
Summary of Study: In vitro infection of human (and to a lesser extent hamster and rhesus monkey) airway tissues revealed hACE2 as the primary receptor for SARS-CoV infection of a model of human ciliated airway epithelium.
References: doi: 10.1128/JVI.79.24.15511-15524.2005
Contact Info: Sims AC, et al.; correspondence to Amy C. Sims ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16306622/
NHP Species: rhesus macaques
Year Published: 2005
Study Type/Review:
NPRC/Institute: NIH grants AI059136, AI059443-01, AI059443; UNC medical alumni endowment fund; Infectious Disease Research Training Grant 5T32AI07151-27
Keywords: SARS-CoV, hACE2, human ciliated airway epithelia
Summary of Study: In vitro infection of human (and to a lesser extent hamster and rhesus monkey) airway tissues revealed hACE2 as the primary receptor for SARS-CoV infection of a model of human ciliated airway epithelium.
References: doi: 10.1128/JVI.79.24.15511-15524.2005
Contact Info: Sims AC, et al.; correspondence to Amy C. Sims ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16306622/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2005
Study Type/Review:
NPRC/Institute: University of Hong Kong
Keywords: SARS coronavirus, mutation, adaptation, selection
Summary of Study: Authors looked at SARS-CoV isolates from nonhuman primate cells for mutations that could provide insight for interspecies infection and the evolution of the SARS virus.
References: doi: 10.1002/jmv.20379
Contact Info: Poon LLM, et al.; correspondence to Joseph SM Peiris ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/15977248/
NHP Species: rhesus macaques
Year Published: 2005
Study Type/Review:
NPRC/Institute: University of Hong Kong
Keywords: SARS coronavirus, mutation, adaptation, selection
Summary of Study: Authors looked at SARS-CoV isolates from nonhuman primate cells for mutations that could provide insight for interspecies infection and the evolution of the SARS virus.
References: doi: 10.1002/jmv.20379
Contact Info: Poon LLM, et al.; correspondence to Joseph SM Peiris ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/15977248/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2005
Study Type/Review: vaccine
NPRC/Institute: Chinese Medicine Foundation
Keywords: SARS-CoV, inactivated vaccine, immune response
Summary of Study: Authors evaluated an inactivated vaccine for SARS at different concentrations in rhesus monkeys. The study showed the vaccine was safe and induced mucosal and concomitant humoral immunity in monkeys.
References: doi: 10.1016/j.vaccine.2004.11.075
Contact Info: Zhou J, et al.; correspondence to Zhanqiu Yang ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/15837221/
NHP Species: rhesus macaques
Year Published: 2005
Study Type/Review: vaccine
NPRC/Institute: Chinese Medicine Foundation
Keywords: SARS-CoV, inactivated vaccine, immune response
Summary of Study: Authors evaluated an inactivated vaccine for SARS at different concentrations in rhesus monkeys. The study showed the vaccine was safe and induced mucosal and concomitant humoral immunity in monkeys.
References: doi: 10.1016/j.vaccine.2004.11.075
Contact Info: Zhou J, et al.; correspondence to Zhanqiu Yang ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/15837221/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2005
Study Type/Review:
NPRC/Institute: Unknown funding
Keywords: SARS, siRNA, RNAi
Summary of Study: Three different treatments significantly reduced the severity of viral-induced SARS symptoms in rhesus macaques.
References: doi: 10.1038/sj.gt.3302682; PMID: 17262907; PMCID: PMC7091734
Contact Info: Chang Z and Hu Z; correspondence to Z. Chang ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/17262907/
NHP Species: rhesus macaques
Year Published: 2005
Study Type/Review:
NPRC/Institute: Unknown funding
Keywords: SARS, siRNA, RNAi
Summary of Study: Three different treatments significantly reduced the severity of viral-induced SARS symptoms in rhesus macaques.
References: doi: 10.1038/sj.gt.3302682; PMID: 17262907; PMCID: PMC7091734
Contact Info: Chang Z and Hu Z; correspondence to Z. Chang ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/17262907/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2005
Study Type/Review: vaccine
NPRC/Institute: Tulane National Primate Research Center, base grant RR00164
Keywords: antibodies, viral, membrane glycoproteins, SARS virus, vaccinia virus, viral envelope proteins
Summary of Study: Administration of a vaccine targeting the S-glycoprotein gene in rhesus macaques resulted in a potent immune response and suggests that this vaccine could be effect in protecting Chinese rhesus macaques from SARS-CoV.
References: doi: 10.1128/JVI.79.5.2678-2688.2005
Contact Info: Chen Z, et al.; correspondence to Zhiwei Chen ([email protected]) and David D. Ho ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/15708987/
NHP Species: rhesus macaques
Year Published: 2005
Study Type/Review: vaccine
NPRC/Institute: Tulane National Primate Research Center, base grant RR00164
Keywords: antibodies, viral, membrane glycoproteins, SARS virus, vaccinia virus, viral envelope proteins
Summary of Study: Administration of a vaccine targeting the S-glycoprotein gene in rhesus macaques resulted in a potent immune response and suggests that this vaccine could be effect in protecting Chinese rhesus macaques from SARS-CoV.
References: doi: 10.1128/JVI.79.5.2678-2688.2005
Contact Info: Chen Z, et al.; correspondence to Zhiwei Chen ([email protected]) and David D. Ho ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/15708987/
Coronavirus Investigated: SARS-CoV
NHP Species: marmosets
Year Published: 2005
Study Type/Review:
NPRC/Institute: University of Massachusetts Medical School
Keywords: SARS, SARS-CoV, pathogenesis
Summary of Study: C. jaccus were intratracheally inoculated with the Urbani strain of SARS-CoV. A variety of symptoms resulted, leading the authors to name the marmoset a promising NHP model for the study of SARS-CoV pathogenesis.
References: doi: 10.1016/S0002-9440(10)62989-6; PMID: 16049331
Contact Info: Greenough T, et al.; correspondence to Thomas Greenough ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16049331/
NHP Species: marmosets
Year Published: 2005
Study Type/Review:
NPRC/Institute: University of Massachusetts Medical School
Keywords: SARS, SARS-CoV, pathogenesis
Summary of Study: C. jaccus were intratracheally inoculated with the Urbani strain of SARS-CoV. A variety of symptoms resulted, leading the authors to name the marmoset a promising NHP model for the study of SARS-CoV pathogenesis.
References: doi: 10.1016/S0002-9440(10)62989-6; PMID: 16049331
Contact Info: Greenough T, et al.; correspondence to Thomas Greenough ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16049331/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2005
Study Type/Review:
NPRC/Institute: Science and Technology Commission, Guangdong Provincial Government, Guangzhou Science and Technology Bureau, Guangzhou Economic & Technological Development District, and China World Trade Corporation (Guangzhou), Top Biotech, Ltd. (Hong Kong), China
Keywords: SARS, SARS-CoV, siRNA
Summary of Study: This study evaluated the efficacy of using siRNA inhibitors to treat SARS coronavirus (SCV) in vitro in rhesus macaques. Results indicated the siRNAs were able to alleviate infection and symptoms of SCV and warrant further investigation for development of new therapeutic agents.
References: doi: 10.1038/nm1280
Contact Info: Li B, et al.; correspondence to Nanshan Zhong ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16116432/
NHP Species: rhesus macaques
Year Published: 2005
Study Type/Review:
NPRC/Institute: Science and Technology Commission, Guangdong Provincial Government, Guangzhou Science and Technology Bureau, Guangzhou Economic & Technological Development District, and China World Trade Corporation (Guangzhou), Top Biotech, Ltd. (Hong Kong), China
Keywords: SARS, SARS-CoV, siRNA
Summary of Study: This study evaluated the efficacy of using siRNA inhibitors to treat SARS coronavirus (SCV) in vitro in rhesus macaques. Results indicated the siRNAs were able to alleviate infection and symptoms of SCV and warrant further investigation for development of new therapeutic agents.
References: doi: 10.1038/nm1280
Contact Info: Li B, et al.; correspondence to Nanshan Zhong ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/16116432/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2005
Study Type/Review:
NPRC/Institute: National High Technology Research and Development Programme of China (863 Programme, Nos 2003AA208201, 2003AA208205, and 2003AA208213); National Nature Science Foundation (No 30340026); National Institutes of Health (AIâ€061318); National Basic Research Programme of China (No 2003CB514109)
Keywords: SARS, coronavirus, animal model, pathology, rhesus monkey
Summary of Study: Authors inoculated eight rhesus macaques with SARS-CoV intranasally and systematically observed their response to the virus. All animals exhibited symptoms and inflammation indicating they are an ideal animal model for vaccine development.
References: doi: 10.1002/path.1769
Contact Info: Qin C, et al.; correspondence to Wei He ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/15892035/
NHP Species: rhesus macaques
Year Published: 2005
Study Type/Review:
NPRC/Institute: National High Technology Research and Development Programme of China (863 Programme, Nos 2003AA208201, 2003AA208205, and 2003AA208213); National Nature Science Foundation (No 30340026); National Institutes of Health (AIâ€061318); National Basic Research Programme of China (No 2003CB514109)
Keywords: SARS, coronavirus, animal model, pathology, rhesus monkey
Summary of Study: Authors inoculated eight rhesus macaques with SARS-CoV intranasally and systematically observed their response to the virus. All animals exhibited symptoms and inflammation indicating they are an ideal animal model for vaccine development.
References: doi: 10.1002/path.1769
Contact Info: Qin C, et al.; correspondence to Wei He ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/15892035/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2004
Study Type/Review:
NPRC/Institute: Homeland Security
Keywords: SARS, SARS-CoV, nonhuman primate
Summary of Study: Rhesus and cynomolgus macaques were challenged with a clinical isolate of SARS-CoV; this treatment did not result in the sort of respiratory infection seen in humans.
References: doi: 10.1128/JVI.78.20.11404-11404.2004; PMID: 15452262
Contact Info: Rowe T, et al.; correspondence to James M. Wilson ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/15452262/
NHP Species: rhesus macaques
Year Published: 2004
Study Type/Review:
NPRC/Institute: Homeland Security
Keywords: SARS, SARS-CoV, nonhuman primate
Summary of Study: Rhesus and cynomolgus macaques were challenged with a clinical isolate of SARS-CoV; this treatment did not result in the sort of respiratory infection seen in humans.
References: doi: 10.1128/JVI.78.20.11404-11404.2004; PMID: 15452262
Contact Info: Rowe T, et al.; correspondence to James M. Wilson ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/15452262/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2004
Study Type/Review:
NPRC/Institute: Department of Microbiology, University of Hong Kong
Keywords: SARS-CoV, siRNA, FRhK-4
Summary of Study: SARS-CoV strain HKU-66078 (AY304494) was used to infect fetal rhesus kidney cells, which were then treated with siRNAs to demonstrate the antiviral effects of this treatment approach.
References: PMID: 15259899
Contact Info: Zheng B, et al.; correspondence to Lu PL([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/15259899/
NHP Species: rhesus macaques
Year Published: 2004
Study Type/Review:
NPRC/Institute: Department of Microbiology, University of Hong Kong
Keywords: SARS-CoV, siRNA, FRhK-4
Summary of Study: SARS-CoV strain HKU-66078 (AY304494) was used to infect fetal rhesus kidney cells, which were then treated with siRNAs to demonstrate the antiviral effects of this treatment approach.
References: PMID: 15259899
Contact Info: Zheng B, et al.; correspondence to Lu PL([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/15259899/
Coronavirus Investigated: SARS-CoV
NHP Species:
Year Published: 2004
Study Type/Review:
NPRC/Institute: Institute of Virology, Erasmus University of Rotterdam
Keywords: SARS, SARS-CoV, Koch’s postulates, etiology
Summary of Study: Cynomolgus macaques were infected with SARS-CoV in a study that identified the novel coronavirus (SARS-CoV) as the primary cause of severe acute respiratory syndrome (SARS).
References: doi: 10.1098/rstb.2004.1489; PMID: 15306393
Contact Info: Osterhaus ADME, et al.; correspondence to Albert Osterhaus ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/15306393/
NHP Species:
Year Published: 2004
Study Type/Review:
NPRC/Institute: Institute of Virology, Erasmus University of Rotterdam
Keywords: SARS, SARS-CoV, Koch’s postulates, etiology
Summary of Study: Cynomolgus macaques were infected with SARS-CoV in a study that identified the novel coronavirus (SARS-CoV) as the primary cause of severe acute respiratory syndrome (SARS).
References: doi: 10.1098/rstb.2004.1489; PMID: 15306393
Contact Info: Osterhaus ADME, et al.; correspondence to Albert Osterhaus ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/15306393/
Coronavirus Investigated: SARS-CoV
NHP Species:
Year Published: 2004
Study Type/Review:
NPRC/Institute: Erasmus Medical Center, Rotterdam, the Netherlands
Keywords: SARS, SARS-CoV, infection, interferon
Summary of Study: Cynomolgus macaques were infected intratracheally with SARS-Co-V, resulting in extensive SCV infection in type 1 pneumocytes. This indicates that this cell type is the primary target for SCV infection early in the disease. Prophylactic treatment with pegylated interferon-α significantly reduces viral replication and excretion and should be considered a candidate drug for SARS therapy.
References: doi: 10.1038/nm1001; PMID: 14981511
Contact Info: Haagmans BL, et al.; correspondence to Albert Osterhaus ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/14981511/
NHP Species:
Year Published: 2004
Study Type/Review:
NPRC/Institute: Erasmus Medical Center, Rotterdam, the Netherlands
Keywords: SARS, SARS-CoV, infection, interferon
Summary of Study: Cynomolgus macaques were infected intratracheally with SARS-Co-V, resulting in extensive SCV infection in type 1 pneumocytes. This indicates that this cell type is the primary target for SCV infection early in the disease. Prophylactic treatment with pegylated interferon-α significantly reduces viral replication and excretion and should be considered a candidate drug for SARS therapy.
References: doi: 10.1038/nm1001; PMID: 14981511
Contact Info: Haagmans BL, et al.; correspondence to Albert Osterhaus ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/14981511/
Coronavirus Investigated: SARS-CoV
NHP Species:
Year Published: 2004
Study Type/Review:
NPRC/Institute: Erasmus Medical Center, Rotterdam, the Netherlands
Keywords: SARS interferon, nonhuman primate
Summary of Study: Cynomolgus macaques that were given pegylated interferon-α 3 days before infection with the SARS virus excreted far less virus from their throats, and their lung damage was reduced by some 80%.
References: doi: 10.1126/science.303.5662.1273a
Contact Info: Enserink M; correspondence to Martin Enserink ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/14988528/
NHP Species:
Year Published: 2004
Study Type/Review:
NPRC/Institute: Erasmus Medical Center, Rotterdam, the Netherlands
Keywords: SARS interferon, nonhuman primate
Summary of Study: Cynomolgus macaques that were given pegylated interferon-α 3 days before infection with the SARS virus excreted far less virus from their throats, and their lung damage was reduced by some 80%.
References: doi: 10.1126/science.303.5662.1273a
Contact Info: Enserink M; correspondence to Martin Enserink ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/14988528/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques, african green monkeys
Year Published: 2004
Study Type/Review:
NPRC/Institute: NIAID
Keywords: replication, SARS, respiratory tract
Summary of Study: SARS-CoV administered intranasally and intratracheally to rhesus, cynomolgus, and African green monkeys replicated in the respiratory tract but did not induce illness.
References: doi: 10.1016/j.virol.2004.09.030; PMID: 15527829
Contact Info: McAuliffe J, et al.; correspondence to Kanta Subbarao ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/15527829/
NHP Species: rhesus macaques, african green monkeys
Year Published: 2004
Study Type/Review:
NPRC/Institute: NIAID
Keywords: replication, SARS, respiratory tract
Summary of Study: SARS-CoV administered intranasally and intratracheally to rhesus, cynomolgus, and African green monkeys replicated in the respiratory tract but did not induce illness.
References: doi: 10.1016/j.virol.2004.09.030; PMID: 15527829
Contact Info: McAuliffe J, et al.; correspondence to Kanta Subbarao ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/15527829/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2004
Study Type/Review:
NPRC/Institute: Homeland Security
Keywords: SARS, SARS-CoV, nonhuman primate
Summary of Study: Rhesus and cynomolgus macaques were challenged with a clinical isolate of SARS-CoV; this treatment did not result in the sort of respiratory infection seen in humans.
References: doi: 10.1128/JVI.78.20.11404-11404.2004; PMID: 15452262
Contact Info: Rowe T, et al.; correspondence to James M. Wilson ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/15452262/
NHP Species: rhesus macaques
Year Published: 2004
Study Type/Review:
NPRC/Institute: Homeland Security
Keywords: SARS, SARS-CoV, nonhuman primate
Summary of Study: Rhesus and cynomolgus macaques were challenged with a clinical isolate of SARS-CoV; this treatment did not result in the sort of respiratory infection seen in humans.
References: doi: 10.1128/JVI.78.20.11404-11404.2004; PMID: 15452262
Contact Info: Rowe T, et al.; correspondence to James M. Wilson ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/15452262/
Coronavirus Investigated: SARS-CoV
NHP Species:
Year Published: 2004
Study Type/Review:
NPRC/Institute: Institute of Virology, Erasmus University of Rotterdam
Keywords: SARS, SARS-CoV, Koch’s postulates, etiology
Summary of Study: Cynomolgus macaques were infected with SARS-CoV in a study that identified the novel coronavirus (SARS-CoV) as the primary cause of severe acute respiratory syndrome (SARS).
References: doi: 10.1098/rstb.2004.1489; PMID: 15306393
Contact Info: Osterhaus ADME, et al.; correspondence to Albert Osterhaus ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/15306393/
NHP Species:
Year Published: 2004
Study Type/Review:
NPRC/Institute: Institute of Virology, Erasmus University of Rotterdam
Keywords: SARS, SARS-CoV, Koch’s postulates, etiology
Summary of Study: Cynomolgus macaques were infected with SARS-CoV in a study that identified the novel coronavirus (SARS-CoV) as the primary cause of severe acute respiratory syndrome (SARS).
References: doi: 10.1098/rstb.2004.1489; PMID: 15306393
Contact Info: Osterhaus ADME, et al.; correspondence to Albert Osterhaus ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/15306393/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2004
Study Type/Review:
NPRC/Institute: Department of Microbiology, University of Hong Kong
Keywords: SARS-CoV, siRNA, FRhK-4
Summary of Study: SARS-CoV strain HKU-66078 (AY304494) was used to infect fetal rhesus kidney cells, which were then treated with siRNAs to demonstrate the antiviral effects of this treatment approach.
References: PMID: 15259899
Contact Info: Zheng B, et al.; correspondence to Lu PL([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/15259899/
NHP Species: rhesus macaques
Year Published: 2004
Study Type/Review:
NPRC/Institute: Department of Microbiology, University of Hong Kong
Keywords: SARS-CoV, siRNA, FRhK-4
Summary of Study: SARS-CoV strain HKU-66078 (AY304494) was used to infect fetal rhesus kidney cells, which were then treated with siRNAs to demonstrate the antiviral effects of this treatment approach.
References: PMID: 15259899
Contact Info: Zheng B, et al.; correspondence to Lu PL([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/15259899/
Coronavirus Investigated: SARS-CoV
NHP Species:
Year Published: 2004
Study Type/Review:
NPRC/Institute: Erasmus Medical Center, Rotterdam, the Netherlands
Keywords: SARS, SARS-CoV, infection, interferon
Summary of Study: Cynomolgus macaques were infected intratracheally with SARS-Co-V, resulting in extensive SCV infection in type 1 pneumocytes. This indicates that this cell type is the primary target for SCV infection early in the disease. Prophylactic treatment with pegylated interferon-α significantly reduces viral replication and excretion and should be considered a candidate drug for SARS therapy.
References: doi: 10.1038/nm1001; PMID: 14981511
Contact Info: Haagmans BL, et al.; correspondence to Albert Osterhaus ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/14981511/
NHP Species:
Year Published: 2004
Study Type/Review:
NPRC/Institute: Erasmus Medical Center, Rotterdam, the Netherlands
Keywords: SARS, SARS-CoV, infection, interferon
Summary of Study: Cynomolgus macaques were infected intratracheally with SARS-Co-V, resulting in extensive SCV infection in type 1 pneumocytes. This indicates that this cell type is the primary target for SCV infection early in the disease. Prophylactic treatment with pegylated interferon-α significantly reduces viral replication and excretion and should be considered a candidate drug for SARS therapy.
References: doi: 10.1038/nm1001; PMID: 14981511
Contact Info: Haagmans BL, et al.; correspondence to Albert Osterhaus ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/14981511/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques, african green monkeys
Year Published: 2004
Study Type/Review:
NPRC/Institute: NIAID
Keywords: replication, SARS, respiratory tract
Summary of Study: SARS-CoV administered intranasally and intratracheally to rhesus, cynomolgus, and African green monkeys replicated in the respiratory tract but did not induce illness.
References: doi: 10.1016/j.virol.2004.09.030; PMID: 15527829
Contact Info: McAuliffe J, et al.; correspondence to Kanta Subbarao ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/15527829/
NHP Species: rhesus macaques, african green monkeys
Year Published: 2004
Study Type/Review:
NPRC/Institute: NIAID
Keywords: replication, SARS, respiratory tract
Summary of Study: SARS-CoV administered intranasally and intratracheally to rhesus, cynomolgus, and African green monkeys replicated in the respiratory tract but did not induce illness.
References: doi: 10.1016/j.virol.2004.09.030; PMID: 15527829
Contact Info: McAuliffe J, et al.; correspondence to Kanta Subbarao ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/15527829/
Coronavirus Investigated: SARS-CoV
NHP Species:
Year Published: 2004
Study Type/Review:
NPRC/Institute: Erasmus Medical Center, Rotterdam, the Netherlands
Keywords: SARS interferon, nonhuman primate
Summary of Study: Cynomolgus macaques that were given pegylated interferon-α 3 days before infection with the SARS virus excreted far less virus from their throats, and their lung damage was reduced by some 80%.
References: doi: 10.1126/science.303.5662.1273a
Contact Info: Enserink M; correspondence to Martin Enserink ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/14988528/
NHP Species:
Year Published: 2004
Study Type/Review:
NPRC/Institute: Erasmus Medical Center, Rotterdam, the Netherlands
Keywords: SARS interferon, nonhuman primate
Summary of Study: Cynomolgus macaques that were given pegylated interferon-α 3 days before infection with the SARS virus excreted far less virus from their throats, and their lung damage was reduced by some 80%.
References: doi: 10.1126/science.303.5662.1273a
Contact Info: Enserink M; correspondence to Martin Enserink ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/14988528/
Coronavirus Investigated: SARS-CoV
NHP Species:
Year Published: 2003
Study Type/Review:
NPRC/Institute: Erasmus Medical Center, Rotterdam, the Netherlands
Keywords: SARS, SARS-CoV, pneumonia
Summary of Study: Four cynomolgus macaques were infected with SARS-CoV which resulted in pneumonia similar to that in humans with SARS. This fulfills the criteria required to prove that SARS-CoV is the primary cause of SARS.
References: doi: 10.1016/S0140-6736(03)13967-0; PMID: 12892955
Contact Info: Kuiken T, et al.; correspondence to T. Kuiken ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/12892955/
NHP Species:
Year Published: 2003
Study Type/Review:
NPRC/Institute: Erasmus Medical Center, Rotterdam, the Netherlands
Keywords: SARS, SARS-CoV, pneumonia
Summary of Study: Four cynomolgus macaques were infected with SARS-CoV which resulted in pneumonia similar to that in humans with SARS. This fulfills the criteria required to prove that SARS-CoV is the primary cause of SARS.
References: doi: 10.1016/S0140-6736(03)13967-0; PMID: 12892955
Contact Info: Kuiken T, et al.; correspondence to T. Kuiken ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/12892955/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2003
Study Type/Review: vaccine
NPRC/Institute: University of Pittsburgh
Keywords: SARS, SARS-CoV, spike protein
Summary of Study: Rhesus macaques were immunized intramuscularly with a combination of the three Ad5-SARS-CoV vectors or a control vector, followed by a booster vaccination on day 28. All vaccinated animals had antibody responses against spike protein S1 fragment and T-cell responses against the nucleocapsid protein, showing that an adenoviral-based vaccine can induce strong immune responses in the monkey.
References: doi: 10.1016/S0140-6736(03)14962-8; PMID: 14667748
Contact Info: Gao W, et al.; correspondence to Andrea Gambotto ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/14667748/
NHP Species: rhesus macaques
Year Published: 2003
Study Type/Review: vaccine
NPRC/Institute: University of Pittsburgh
Keywords: SARS, SARS-CoV, spike protein
Summary of Study: Rhesus macaques were immunized intramuscularly with a combination of the three Ad5-SARS-CoV vectors or a control vector, followed by a booster vaccination on day 28. All vaccinated animals had antibody responses against spike protein S1 fragment and T-cell responses against the nucleocapsid protein, showing that an adenoviral-based vaccine can induce strong immune responses in the monkey.
References: doi: 10.1016/S0140-6736(03)14962-8; PMID: 14667748
Contact Info: Gao W, et al.; correspondence to Andrea Gambotto ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/14667748/
Coronavirus Investigated: SARS-CoV
NHP Species:
Year Published: 2003
Study Type/Review:
NPRC/Institute: Erasmus Medical Center, Rotterdam, the Netherlands
Keywords: SARS, SARS-CoV, pneumonia
Summary of Study: Four cynomolgus macaques were infected with SARS-CoV which resulted in pneumonia similar to that in humans with SARS. This fulfills the criteria required to prove that SARS-CoV is the primary cause of SARS.
References: doi: 10.1016/S0140-6736(03)13967-0; PMID: 12892955
Contact Info: Kuiken T, et al.; correspondence to T. Kuiken ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/12892955/
NHP Species:
Year Published: 2003
Study Type/Review:
NPRC/Institute: Erasmus Medical Center, Rotterdam, the Netherlands
Keywords: SARS, SARS-CoV, pneumonia
Summary of Study: Four cynomolgus macaques were infected with SARS-CoV which resulted in pneumonia similar to that in humans with SARS. This fulfills the criteria required to prove that SARS-CoV is the primary cause of SARS.
References: doi: 10.1016/S0140-6736(03)13967-0; PMID: 12892955
Contact Info: Kuiken T, et al.; correspondence to T. Kuiken ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/12892955/
Coronavirus Investigated: SARS-CoV
NHP Species: rhesus macaques
Year Published: 2003
Study Type/Review: vaccine
NPRC/Institute: University of Pittsburgh
Keywords: SARS, SARS-CoV, spike protein
Summary of Study: Rhesus macaques were immunized intramuscularly with a combination of the three Ad5-SARS-CoV vectors or a control vector, followed by a booster vaccination on day 28. All vaccinated animals had antibody responses against spike protein S1 fragment and T-cell responses against the nucleocapsid protein, showing that an adenoviral-based vaccine can induce strong immune responses in the monkey.
References: doi: 10.1016/S0140-6736(03)14962-8; PMID: 14667748
Contact Info: Gao W, et al.; correspondence to Andrea Gambotto ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/14667748/
NHP Species: rhesus macaques
Year Published: 2003
Study Type/Review: vaccine
NPRC/Institute: University of Pittsburgh
Keywords: SARS, SARS-CoV, spike protein
Summary of Study: Rhesus macaques were immunized intramuscularly with a combination of the three Ad5-SARS-CoV vectors or a control vector, followed by a booster vaccination on day 28. All vaccinated animals had antibody responses against spike protein S1 fragment and T-cell responses against the nucleocapsid protein, showing that an adenoviral-based vaccine can induce strong immune responses in the monkey.
References: doi: 10.1016/S0140-6736(03)14962-8; PMID: 14667748
Contact Info: Gao W, et al.; correspondence to Andrea Gambotto ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/14667748/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: COVAXX, Inc.; United Biomedical Inc., Asia; United BioPharma; United Biomedical Inc., USA; Academia Sinica; University of Texas Medical Branch; Galveston National Laboratory
Keywords: SARS-CoV-2, multitope protein-peptide vaccine, immunogenicity, protection, mice, rats, Guinea pigs, primates
Summary of Study: With a Phase 1 trial ongoing in Taiwan and additional trials planned worldwide, UB-612 is a highly promising and differentiated vaccine candidate for prevention of SARS-CoV-2 transmission and COVID-19 disease.
References: doi: 10.1101/2020.11.30.399154
Contact Info: Chang Yi Wang: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.11.30.399154v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: COVAXX, Inc.; United Biomedical Inc., Asia; United BioPharma; United Biomedical Inc., USA; Academia Sinica; University of Texas Medical Branch; Galveston National Laboratory
Keywords: SARS-CoV-2, multitope protein-peptide vaccine, immunogenicity, protection, mice, rats, Guinea pigs, primates
Summary of Study: With a Phase 1 trial ongoing in Taiwan and additional trials planned worldwide, UB-612 is a highly promising and differentiated vaccine candidate for prevention of SARS-CoV-2 transmission and COVID-19 disease.
References: doi: 10.1101/2020.11.30.399154
Contact Info: Chang Yi Wang: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.11.30.399154v1