Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Northwestern University Feinberg School of Medicine; Tulane National Primate Research Center; New Iberia Research Center
Keywords: SARS-CoV-2, male genital tract, positron emission tomography, pathogenesis, primates
Summary of Study: Results suggest that SARS-CoV-2 rapidly and efficiently infects multiple tissues of the male genital tract (MGT) early during infection in rhesus macaques.
References: PMID: 35262081 / doi: 10.1101/2022.02.25.481974
Contact Info: Thomas J. Hope: thope@northwestern.edu
URL: https://www.biorxiv.org/content/10.1101/2022.02.25.481974v2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Northwestern University Feinberg School of Medicine; Tulane National Primate Research Center; New Iberia Research Center
Keywords: SARS-CoV-2, male genital tract, positron emission tomography, pathogenesis, primates
Summary of Study: Results suggest that SARS-CoV-2 rapidly and efficiently infects multiple tissues of the male genital tract (MGT) early during infection in rhesus macaques.
References: PMID: 35262081 / doi: 10.1101/2022.02.25.481974
Contact Info: Thomas J. Hope: thope@northwestern.edu
URL: https://www.biorxiv.org/content/10.1101/2022.02.25.481974v2
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Perelman School of medicine; University of Wisconsin-Medison; The Children's Hospital of Philadelphia; Cardiomyogen; ORRA Group, LLC; Stanford University, and others
Keywords: SARS-CoV-2, AAV vectors, immunization, immune response, mice, primates
Summary of Study: These studies demonstrate not only that AAV6 and AAV9 can function as effective vaccine platforms, but also that vaccine can provide long-term efficacy primarily through the induction of cellular immunity.
References: doi: 10.1101/2021.08.16.456441
Contact Info: Hansell Stedman: hstedman@mail.med.upenn.edu
URL: https://www.biorxiv.org/content/10.1101/2021.08.16.456441v1.article-metrics
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Perelman School of medicine; University of Wisconsin-Medison; The Children's Hospital of Philadelphia; Cardiomyogen; ORRA Group, LLC; Stanford University, and others
Keywords: SARS-CoV-2, AAV vectors, immunization, immune response, mice, primates
Summary of Study: These studies demonstrate not only that AAV6 and AAV9 can function as effective vaccine platforms, but also that vaccine can provide long-term efficacy primarily through the induction of cellular immunity.
References: doi: 10.1101/2021.08.16.456441
Contact Info: Hansell Stedman: hstedman@mail.med.upenn.edu
URL: https://www.biorxiv.org/content/10.1101/2021.08.16.456441v1.article-metrics
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Yerkes National Primate Research Center; University of Pittsburgh; Emory University School of Medicine
Keywords: SARS-CoV-2, macrophages, inflammation, mRNA analysis, kinase inhibitor, primates
Summary of Study: Multi-omic analyses of hyperacute SARS-CoV-2 infection in rhesus macaques identified two populations of infiltrating macrophages as the primary orchestrators of inflammation in the lower airway that can be successfully treated with baricitinib.
References: doi: 10.1101/2021.10.05.463212
Contact Info: Steven Bosinger: steven.bosinger@emory.edu; Mirko Paiardini: mirko.paiardini@emory.edu
URL: https://www.biorxiv.org/content/10.1101/2021.10.05.463212v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Yerkes National Primate Research Center; University of Pittsburgh; Emory University School of Medicine
Keywords: SARS-CoV-2, macrophages, inflammation, mRNA analysis, kinase inhibitor, primates
Summary of Study: Multi-omic analyses of hyperacute SARS-CoV-2 infection in rhesus macaques identified two populations of infiltrating macrophages as the primary orchestrators of inflammation in the lower airway that can be successfully treated with baricitinib.
References: doi: 10.1101/2021.10.05.463212
Contact Info: Steven Bosinger: steven.bosinger@emory.edu; Mirko Paiardini: mirko.paiardini@emory.edu
URL: https://www.biorxiv.org/content/10.1101/2021.10.05.463212v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Laboratory of Virology (NIAID/NIH), Rocky Mountain Veterinary Branch (NIAID/NIH), CureVac AG
Keywords: SARS-CoV-2, mRNA vaccine candidate, humoral and cellular immune responses, primates
Summary of Study: A new SARS-CoV-2 S mRNA vaccine, CV07050101 was investigated in NHPs. Prime-boost vaccination of rhesus macaques with 4 ug of CV07050101 does not elicit a uniform nor robust immune response; however, vaccination using 8 ug of the same vaccine demonstrated protection.
References: PMID: 34268507 / doi: 10.1101/202.07.07.451505
Contact Info: Vincent Munster: vincent.munster@nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.07.07.451505v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Laboratory of Virology (NIAID/NIH), Rocky Mountain Veterinary Branch (NIAID/NIH), CureVac AG
Keywords: SARS-CoV-2, mRNA vaccine candidate, humoral and cellular immune responses, primates
Summary of Study: A new SARS-CoV-2 S mRNA vaccine, CV07050101 was investigated in NHPs. Prime-boost vaccination of rhesus macaques with 4 ug of CV07050101 does not elicit a uniform nor robust immune response; however, vaccination using 8 ug of the same vaccine demonstrated protection.
References: PMID: 34268507 / doi: 10.1101/202.07.07.451505
Contact Info: Vincent Munster: vincent.munster@nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.07.07.451505v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Scripps Research Institute; MIT; UCSD; Howard Hughes Medican Institute
Keywords: SARS-CoV-2, receptor-binding domain vaccine, structural studies, immune response, primates
Summary of Study: Broadly neutralizing antibodies to an unappreciated site of conservation in the RBD in SARS-related viruses can be readily induced in rhesus macaques because of distinct properties of the naive macaque B cell repertoire that suggest prudence in the use of the macaque model in SARS vaccine evaluation and design.
References: doi: 10.1101/2021.07.05.451222
Contact Info: Ian Wilson: wilson@scripps.edu; Dennis Burton: burton@scripps.edu; Raiees Andrabi: andrabi@scripps.edu
URL: https://www.biorxiv.org/content/10.1101/2021.07.05.451222v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Scripps Research Institute; MIT; UCSD; Howard Hughes Medican Institute
Keywords: SARS-CoV-2, receptor-binding domain vaccine, structural studies, immune response, primates
Summary of Study: Broadly neutralizing antibodies to an unappreciated site of conservation in the RBD in SARS-related viruses can be readily induced in rhesus macaques because of distinct properties of the naive macaque B cell repertoire that suggest prudence in the use of the macaque model in SARS vaccine evaluation and design.
References: doi: 10.1101/2021.07.05.451222
Contact Info: Ian Wilson: wilson@scripps.edu; Dennis Burton: burton@scripps.edu; Raiees Andrabi: andrabi@scripps.edu
URL: https://www.biorxiv.org/content/10.1101/2021.07.05.451222v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Peking University Health Science Center, Beijing, China
Keywords: SARS-CoV-2, TLR4, trimeric spike protein binding, primates
Summary of Study: The spike protein of SARS-CoV-2 functions as a potent stimulus causing TLR4 activation and sepsis related abnormal responses.
References: doi: https://doi.org/10.1101/2020.12.18.423427
Contact Info: Xiangxi Wang: xiangxi@idp.ac.cn/Fuping You: fupingyou@hsc.pku.edu.cn
URL: https://www.biorxiv.org/content/10.1101/2020.12.18.423427v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Peking University Health Science Center, Beijing, China
Keywords: SARS-CoV-2, TLR4, trimeric spike protein binding, primates
Summary of Study: The spike protein of SARS-CoV-2 functions as a potent stimulus causing TLR4 activation and sepsis related abnormal responses.
References: doi: https://doi.org/10.1101/2020.12.18.423427
Contact Info: Xiangxi Wang: xiangxi@idp.ac.cn/Fuping You: fupingyou@hsc.pku.edu.cn
URL: https://www.biorxiv.org/content/10.1101/2020.12.18.423427v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Duke Human Vaccine Institute
Keywords: SARS-CoV-2, multimeric receptor binding domain nanoparticle, cross-neutralizing antibody, virus variants, primates
Summary of Study: This study demonstrates the ability of a SARS-CoV-2 RBD 24-mer subunit nanoparticle vaccine to elicit potent cross-neutralizing antibodies against SARS-CoV-1, SARS-CoV-2, SARS-CoV-2 variant B.1.1.7. as well as SARS-related bat betaCoVs.
References: PMID: 33619494 / doi: 10.1101/2021.02.17.431492
Contact Info: Kevin Saunders: kevin.saunders@duke.edu
URL: https://www.biorxiv.org/content/10.1101/2021.02.17.431492v1
NHP Species: multiple species
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Duke Human Vaccine Institute
Keywords: SARS-CoV-2, multimeric receptor binding domain nanoparticle, cross-neutralizing antibody, virus variants, primates
Summary of Study: This study demonstrates the ability of a SARS-CoV-2 RBD 24-mer subunit nanoparticle vaccine to elicit potent cross-neutralizing antibodies against SARS-CoV-1, SARS-CoV-2, SARS-CoV-2 variant B.1.1.7. as well as SARS-related bat betaCoVs.
References: PMID: 33619494 / doi: 10.1101/2021.02.17.431492
Contact Info: Kevin Saunders: kevin.saunders@duke.edu
URL: https://www.biorxiv.org/content/10.1101/2021.02.17.431492v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: BGI-Shenzhen; University of Chinese Academy of Sciences; Guangzhou Institutes of Biomedicine and Health; University of Copenhagen, Huazhen Biosciences, Kunming University of Science and Technology; University of Cambridge, and others.
Keywords: SARS-CoV-2, transcriptome, virus entry, immune response, primates
Summary of Study: The transcriptome of nine organs at single-cell resolution was profiled in monkeys.
References: doi: 10.1101/2020.04.10.022103
Contact Info: Xun Xu: xuxun@genomics.cn; Yong Hou: houyong@genomics.cn; Miguel Estaban: miguel@gibh.ac.cn
URL: https://www.biorxiv.org/content/10.1101/2020.04.10.022103v2
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: BGI-Shenzhen; University of Chinese Academy of Sciences; Guangzhou Institutes of Biomedicine and Health; University of Copenhagen, Huazhen Biosciences, Kunming University of Science and Technology; University of Cambridge, and others.
Keywords: SARS-CoV-2, transcriptome, virus entry, immune response, primates
Summary of Study: The transcriptome of nine organs at single-cell resolution was profiled in monkeys.
References: doi: 10.1101/2020.04.10.022103
Contact Info: Xun Xu: xuxun@genomics.cn; Yong Hou: houyong@genomics.cn; Miguel Estaban: miguel@gibh.ac.cn
URL: https://www.biorxiv.org/content/10.1101/2020.04.10.022103v2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: National Cancer Institute/NIH; BIOQUAL; University of Athens; University of Washington
Keywords: SARS-CoV-2, DNA-based vaccine, immune response, primates
Summary of Study: A vaccine regimen comprising simultaneous co-immunization of DNA and Protein at the same anatomical site showed best neutralizing abilities and was more effective than DNA alone in inducing protective immune responses and controlling SARS-CoV-2 infection.
References: doi: 10.1101/2021.06.11.448032
Contact Info: Barbara Felber: barbara.felber@nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.06.11.448032v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: National Cancer Institute/NIH; BIOQUAL; University of Athens; University of Washington
Keywords: SARS-CoV-2, DNA-based vaccine, immune response, primates
Summary of Study: A vaccine regimen comprising simultaneous co-immunization of DNA and Protein at the same anatomical site showed best neutralizing abilities and was more effective than DNA alone in inducing protective immune responses and controlling SARS-CoV-2 infection.
References: doi: 10.1101/2021.06.11.448032
Contact Info: Barbara Felber: barbara.felber@nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.06.11.448032v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: CAS Key Laboratory of Infection and Immunity, Beijing, China
Keywords: SARS-CoV-2, therapeutics, human monoclonal antibody, primates
Summary of Study: The authors identify and characterize a potent human monoclonal antibody, HB27, that blocks SARS-CoV-2 attachment to its cellular receptor at sub-nM concentrations. Rhesus macaques showed no obvious adverse events when they received a 10-fold effective dose. These results suggest that HB27 is a promising candidate for COVID-19 immuno-therapies.
References: doi:Â https://doi.org/10.1101/2020.11.24.393629
Contact Info: Xiangxi Wang: xiangxi@idp.ac.cn; Cheng-Feng Qin: qincf@bmi.ac.cn
URL: https://www.biorxiv.org/content/10.1101/2020.11.24.393629v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: CAS Key Laboratory of Infection and Immunity, Beijing, China
Keywords: SARS-CoV-2, therapeutics, human monoclonal antibody, primates
Summary of Study: The authors identify and characterize a potent human monoclonal antibody, HB27, that blocks SARS-CoV-2 attachment to its cellular receptor at sub-nM concentrations. Rhesus macaques showed no obvious adverse events when they received a 10-fold effective dose. These results suggest that HB27 is a promising candidate for COVID-19 immuno-therapies.
References: doi:Â https://doi.org/10.1101/2020.11.24.393629
Contact Info: Xiangxi Wang: xiangxi@idp.ac.cn; Cheng-Feng Qin: qincf@bmi.ac.cn
URL: https://www.biorxiv.org/content/10.1101/2020.11.24.393629v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: Duke University, UNC Chapel Hill, NIAID, Ragon Inst.
Keywords: SARS-CoV-2, neutralizing antibodies, cryo-electron microscopy, binding, inflammation, primates
Summary of Study: SARS-CoV-2 RBD and NTD antibodies can increase infection in vitro, but either protect or do not increase coronavirus replication in mouse and monkey models in vivo.
References: PMID: 33442694 / doi: 10.1101/2020.12.31.424729
Contact Info: Kevin Saunders: kevin.saunders@duke.edu
URL: https://www.biorxiv.org/content/10.1101/2020.12.31.424729v2
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: Duke University, UNC Chapel Hill, NIAID, Ragon Inst.
Keywords: SARS-CoV-2, neutralizing antibodies, cryo-electron microscopy, binding, inflammation, primates
Summary of Study: SARS-CoV-2 RBD and NTD antibodies can increase infection in vitro, but either protect or do not increase coronavirus replication in mouse and monkey models in vivo.
References: PMID: 33442694 / doi: 10.1101/2020.12.31.424729
Contact Info: Kevin Saunders: kevin.saunders@duke.edu
URL: https://www.biorxiv.org/content/10.1101/2020.12.31.424729v2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: ImmunityBio, NantK west, Inc., IosBio
Keywords: SARS-CoV-2, hAd5 S-Fusion + N-ETSD vaccine, efficacy, primates
Summary of Study: NHP immunized with the hAd5 S-Fusion + N-ETSD vaccine generated anti-S IgG and showed inhibition in cPass and thus the presence of anti-S RBD neutralizing antibodies (nAbs).
References: doi: 10.1101/2020.12.08.416297
Contact Info: Patrick Soon-Shiong: patrick@nantworks.com
URL: https://www.biorxiv.org/content/10.1101/2020.12.08.416297v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: ImmunityBio, NantK west, Inc., IosBio
Keywords: SARS-CoV-2, hAd5 S-Fusion + N-ETSD vaccine, efficacy, primates
Summary of Study: NHP immunized with the hAd5 S-Fusion + N-ETSD vaccine generated anti-S IgG and showed inhibition in cPass and thus the presence of anti-S RBD neutralizing antibodies (nAbs).
References: doi: 10.1101/2020.12.08.416297
Contact Info: Patrick Soon-Shiong: patrick@nantworks.com
URL: https://www.biorxiv.org/content/10.1101/2020.12.08.416297v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Intuitive Biosciences
Keywords: SARS-CoV-2, spike binding antibodies with neutralizing activity, immunization, primates
Summary of Study: Efficacy of vaccine candidates based on the SARS-CoV-2 spike was assessed in cynomolgus macaques by examinating their ability to generate spike binding antibodies with neutralizing activity. Neutralizing activity persisted for more than 20 weeks. These data support the utility of spike subunit-based antigens as a vaccine for use in humans.
References: PMID: 33398285/doi: 10.1101/2020.12.20.422693
Contact Info: Kimberly Luke (no contact information)
URL: https://www.biorxiv.org/content/10.1101/2020.12.20.422693v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Intuitive Biosciences
Keywords: SARS-CoV-2, spike binding antibodies with neutralizing activity, immunization, primates
Summary of Study: Efficacy of vaccine candidates based on the SARS-CoV-2 spike was assessed in cynomolgus macaques by examinating their ability to generate spike binding antibodies with neutralizing activity. Neutralizing activity persisted for more than 20 weeks. These data support the utility of spike subunit-based antigens as a vaccine for use in humans.
References: PMID: 33398285/doi: 10.1101/2020.12.20.422693
Contact Info: Kimberly Luke (no contact information)
URL: https://www.biorxiv.org/content/10.1101/2020.12.20.422693v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID, Emory, OLAW,
Keywords: SARS-CoV-2, parainfluenza virus-vectored vaccine, pediatric, immune response, primates
Summary of Study: Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine candidate is protective in macaques
References: PMID: 35665011 PMCID: PMC9164439 DOI: 10.1101/2022.05.21.492923
Contact Info: Ursula J. Buchholz: ubuchholz@niaid.nih.gov
URL: https://www.biorxiv.org/content/10.1101/2022.05.21.492923v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID, Emory, OLAW,
Keywords: SARS-CoV-2, parainfluenza virus-vectored vaccine, pediatric, immune response, primates
Summary of Study: Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine candidate is protective in macaques
References: PMID: 35665011 PMCID: PMC9164439 DOI: 10.1101/2022.05.21.492923
Contact Info: Ursula J. Buchholz: ubuchholz@niaid.nih.gov
URL: https://www.biorxiv.org/content/10.1101/2022.05.21.492923v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published:
Study Type/Review:
NPRC/Institute: Tsinghua University; Chongqing Medical University; Chinese Academy of Sciences; Shenzhen Bay Laboratory; Peking University Shenzhen Graduate School, Fudan University
Keywords: SARS-CoV-2, virus variants, entry efficiency, host tropism, sensitivity to neutralizing antibodies, primates
Summary of Study: Results demonstrated that the spike protein of Kappa, Delta or B.1.618 with distinct mutations have altered their ability in utilizing ACE2 orthologs for cell entry.
References: doi: 10.1101/2021.09.03.458829
Contact Info: Qiang Ding: qding@tsinghua.edu.cn
URL: https://www.biorxiv.org/content/10.1101/2021.09.03.458829v1
NHP Species: marmosets
Year Published:
Study Type/Review:
NPRC/Institute: Tsinghua University; Chongqing Medical University; Chinese Academy of Sciences; Shenzhen Bay Laboratory; Peking University Shenzhen Graduate School, Fudan University
Keywords: SARS-CoV-2, virus variants, entry efficiency, host tropism, sensitivity to neutralizing antibodies, primates
Summary of Study: Results demonstrated that the spike protein of Kappa, Delta or B.1.618 with distinct mutations have altered their ability in utilizing ACE2 orthologs for cell entry.
References: doi: 10.1101/2021.09.03.458829
Contact Info: Qiang Ding: qding@tsinghua.edu.cn
URL: https://www.biorxiv.org/content/10.1101/2021.09.03.458829v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published:
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Zalgen Labs, LLC., Duke University Medical Center
Keywords: SARS-CoV-2, route of experimental infection, immune response, pathology, primates
Summary of Study: Lack of regenerative activity in the lung was present in both species post-resolution of most of the viral RNA, indicating the NHP model of SARS-CoV-2 infection can be utilized during anti-fibrosis therapeutic development and evaluation and has potential utility in evaluation of post-acute COVID sequelae.
References: doi: 10.1101/2021.11.28.470250
Contact Info: Chad Roy: croy@tulane.edu
URL: https://www.biorxiv.org/content/10.1101/2021.11.28.470250v1
NHP Species: rhesus macaques, african green monkeys
Year Published:
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Zalgen Labs, LLC., Duke University Medical Center
Keywords: SARS-CoV-2, route of experimental infection, immune response, pathology, primates
Summary of Study: Lack of regenerative activity in the lung was present in both species post-resolution of most of the viral RNA, indicating the NHP model of SARS-CoV-2 infection can be utilized during anti-fibrosis therapeutic development and evaluation and has potential utility in evaluation of post-acute COVID sequelae.
References: doi: 10.1101/2021.11.28.470250
Contact Info: Chad Roy: croy@tulane.edu
URL: https://www.biorxiv.org/content/10.1101/2021.11.28.470250v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published:
Study Type/Review:
NPRC/Institute: Laboratory of Virology; NIAID/NIH; University of Plymouth; The Vaccine Group, Ltd.
Keywords: SARS-CoV-2, intranasal infection, genome variants, immune response, primates
Summary of Study: UK B.1.1.7 infection of African green monkeys exhibits increased respiratory replication and shedding but no disease enhancement.
References: PMID: 34159332 / doi: 10.1101/2021.06.11.448134
Contact Info: Heinz Feldmann: feldmannh@niaid.nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.06.11.448134v1
NHP Species: african green monkeys
Year Published:
Study Type/Review:
NPRC/Institute: Laboratory of Virology; NIAID/NIH; University of Plymouth; The Vaccine Group, Ltd.
Keywords: SARS-CoV-2, intranasal infection, genome variants, immune response, primates
Summary of Study: UK B.1.1.7 infection of African green monkeys exhibits increased respiratory replication and shedding but no disease enhancement.
References: PMID: 34159332 / doi: 10.1101/2021.06.11.448134
Contact Info: Heinz Feldmann: feldmannh@niaid.nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.06.11.448134v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: lemurs, lorises
Year Published:
Study Type/Review:
NPRC/Institute: Univ. of Calgary, Institut de Biologia Evolutiva, New York Univ., and others
Keywords: SARS-CoV-2, ACE2 gene and protein sequences, several species, primates
Summary of Study: Susceptibility to SARS-CoV-2 is not equal across non-human primates. This study suggests that several clades of lemurs have a high potential susceptibility to SARS-CoV-2 infection. As they are among the primates at highest risk of extinction globally, further understanding of their risk should be a conservation priority. All feasible actions should be taken to limit their exposure to SARS-CoV-2.
References: PMID: 33564767 / doi: 10.1101/2021.02.03.429540
Contact Info: James Higham: jhigham@nyu.edu; Amanda Melin: amanda.melin@ucalgary.ca
URL: https://www.biorxiv.org/content/10.1101/2021.02.03.429540v1
NHP Species: lemurs, lorises
Year Published:
Study Type/Review:
NPRC/Institute: Univ. of Calgary, Institut de Biologia Evolutiva, New York Univ., and others
Keywords: SARS-CoV-2, ACE2 gene and protein sequences, several species, primates
Summary of Study: Susceptibility to SARS-CoV-2 is not equal across non-human primates. This study suggests that several clades of lemurs have a high potential susceptibility to SARS-CoV-2 infection. As they are among the primates at highest risk of extinction globally, further understanding of their risk should be a conservation priority. All feasible actions should be taken to limit their exposure to SARS-CoV-2.
References: PMID: 33564767 / doi: 10.1101/2021.02.03.429540
Contact Info: James Higham: jhigham@nyu.edu; Amanda Melin: amanda.melin@ucalgary.ca
URL: https://www.biorxiv.org/content/10.1101/2021.02.03.429540v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Pathogen and Biosecurity, Beijing, China
Keywords: SARS-CoV-2, recombinant subunit vaccine, neutralization potency, aged animals, primates
Summary of Study: Authors developed a pilot scale pipeline producing a recombinant subunit vaccine (RBD-Fc Vacc) with Receptor Binding Domain of SARS-CoV-2S protein fused with the Fc domain of human IgG1. This vaccine induced SARS-CoV-2 specific neutralizing antibodies in non-human primates and human ACE2 transgenic mice and is currently being assessed in randomized controlled phase I/II human clinical trials.
References: doi: https://doi.org/10.1101/2020.11.29.402339
Contact Info: Yuwei Gao: gaoyuwei@gmail.com; Wenjin Wei: weiwenjin66@126.com; Zhonghu Hu: huzy67@163.com
URL: https://www.biorxiv.org/content/10.1101/2020.11.29.402339v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Pathogen and Biosecurity, Beijing, China
Keywords: SARS-CoV-2, recombinant subunit vaccine, neutralization potency, aged animals, primates
Summary of Study: Authors developed a pilot scale pipeline producing a recombinant subunit vaccine (RBD-Fc Vacc) with Receptor Binding Domain of SARS-CoV-2S protein fused with the Fc domain of human IgG1. This vaccine induced SARS-CoV-2 specific neutralizing antibodies in non-human primates and human ACE2 transgenic mice and is currently being assessed in randomized controlled phase I/II human clinical trials.
References: doi: https://doi.org/10.1101/2020.11.29.402339
Contact Info: Yuwei Gao: gaoyuwei@gmail.com; Wenjin Wei: weiwenjin66@126.com; Zhonghu Hu: huzy67@163.com
URL: https://www.biorxiv.org/content/10.1101/2020.11.29.402339v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Clover Biopharmaceuticals, Chengdu, China
Keywords: SARS-CoV-2, Trimer-Tag technology, neutralizing antibodies, primates
Summary of Study: Rhesus macaques immunized with adjuvanted S-Trimer were protected from SARS-CoV-2 challenge compared to vehicle controls. Trimer-Tag may be an important new platform technology for scalable production and rapid development of safe and effective subunit vaccines against current and future emerging RNA viruses.
References: doi: https://doi.org/10.1101/2020.09.24.311027
Contact Info: Pen Liang: liang.peng@cloverbiopharma.com
URL: https://www.biorxiv.org/content/10.1101/2020.09.24.311027v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Clover Biopharmaceuticals, Chengdu, China
Keywords: SARS-CoV-2, Trimer-Tag technology, neutralizing antibodies, primates
Summary of Study: Rhesus macaques immunized with adjuvanted S-Trimer were protected from SARS-CoV-2 challenge compared to vehicle controls. Trimer-Tag may be an important new platform technology for scalable production and rapid development of safe and effective subunit vaccines against current and future emerging RNA viruses.
References: doi: https://doi.org/10.1101/2020.09.24.311027
Contact Info: Pen Liang: liang.peng@cloverbiopharma.com
URL: https://www.biorxiv.org/content/10.1101/2020.09.24.311027v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Duke University, NIAID, 3 M Company
Keywords: SARS-CoV-2, receptor binding domain nanoparticle, vaccination, immune response, primates
Summary of Study: An RBD-scNP vaccine induced robust protective immunity for SARS-CoV-2 replication in the upper and lower respiratory tract. This vaccine represents a platform for producing a pancoronavirus vaccine that could prevent, rapidly temper, or extinguish the next spillover of a coronavirus into humans.
References: doi: 10.1101/2021.02.17.431492
Contact Info: Kevin Saunders: kevin.saunders@duke.edu; Barton Haynes: barton.haynes@duke.edu
URL: https://www.biorxiv.org/content/10.1101/2021.02.17.431492v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Duke University, NIAID, 3 M Company
Keywords: SARS-CoV-2, receptor binding domain nanoparticle, vaccination, immune response, primates
Summary of Study: An RBD-scNP vaccine induced robust protective immunity for SARS-CoV-2 replication in the upper and lower respiratory tract. This vaccine represents a platform for producing a pancoronavirus vaccine that could prevent, rapidly temper, or extinguish the next spillover of a coronavirus into humans.
References: doi: 10.1101/2021.02.17.431492
Contact Info: Kevin Saunders: kevin.saunders@duke.edu; Barton Haynes: barton.haynes@duke.edu
URL: https://www.biorxiv.org/content/10.1101/2021.02.17.431492v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center; Washington University SOM; TX Biomedical Research Institute; Tulane University
Keywords: SARS-CoV-2, bronchoalveolar lavage, transcription profiling, immune response, primates
Summary of Study: The recruitment of a myeloid-cell-mediated Type I IFN response is associated with the rapid clearance of SARS-CoV-2 infection in macaques.
References: PMID: 34282414 / doi: 10.21203/rs.3.rs-664507/v1
Contact Info: Dhiraj Singh: dkaushal@txbiomed.org
URL: https://www.researchsquare.com/article/rs-664507/v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center; Washington University SOM; TX Biomedical Research Institute; Tulane University
Keywords: SARS-CoV-2, bronchoalveolar lavage, transcription profiling, immune response, primates
Summary of Study: The recruitment of a myeloid-cell-mediated Type I IFN response is associated with the rapid clearance of SARS-CoV-2 infection in macaques.
References: PMID: 34282414 / doi: 10.21203/rs.3.rs-664507/v1
Contact Info: Dhiraj Singh: dkaushal@txbiomed.org
URL: https://www.researchsquare.com/article/rs-664507/v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Vyriad Inc.; Imanis Life Sciences; Mayo Clinic; Regeneron Pharmaceuticals, Inc.; University of Minnesota
Keywords: SARS-CoV-2, oral rhabdoviral vaccine, boost, immune response, primates
Summary of Study: A relevant translational NHP model was used to demonstrate the safety and oral immunogenicity of a VSV-derived mucosal vaccine for SARS-CoV-2. Pre-IND discussion with FDA are ongoing.
References: doi: 10.1101/2021.10.16.464660
Contact Info: Stephen Russell: sjrussell@vyriad.com
URL: https://www.biorxiv.org/content/10.1101/2021.10.16.464660v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Vyriad Inc.; Imanis Life Sciences; Mayo Clinic; Regeneron Pharmaceuticals, Inc.; University of Minnesota
Keywords: SARS-CoV-2, oral rhabdoviral vaccine, boost, immune response, primates
Summary of Study: A relevant translational NHP model was used to demonstrate the safety and oral immunogenicity of a VSV-derived mucosal vaccine for SARS-CoV-2. Pre-IND discussion with FDA are ongoing.
References: doi: 10.1101/2021.10.16.464660
Contact Info: Stephen Russell: sjrussell@vyriad.com
URL: https://www.biorxiv.org/content/10.1101/2021.10.16.464660v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, pigtail macaques
Year Published:
Study Type/Review:
NPRC/Institute: National Institute of Animal Biotechnology, Telangana, India
Keywords: SARS-CoV-2, ACE2 receptor of various species, several species.
Summary of Study: The interaction of SARS-CoV-2 spike receptor-binding domain with its receptor (ACE2) in different hosts was evaluated to understand and predict viral entry. Most of the species considered in this study showed high probability of viral entry and should be followed to determine their ability to act as carriers and/or disseminators.
References: doi: https://doi.org/10.1101/2020.05.08.084327
Contact Info: Ravi Kumar Gandham: ravigandham@niab.org.in
URL: https://www.biorxiv.org/content/10.1101/2020.05.08.084327v4
NHP Species: rhesus macaques, pigtail macaques
Year Published:
Study Type/Review:
NPRC/Institute: National Institute of Animal Biotechnology, Telangana, India
Keywords: SARS-CoV-2, ACE2 receptor of various species, several species.
Summary of Study: The interaction of SARS-CoV-2 spike receptor-binding domain with its receptor (ACE2) in different hosts was evaluated to understand and predict viral entry. Most of the species considered in this study showed high probability of viral entry and should be followed to determine their ability to act as carriers and/or disseminators.
References: doi: https://doi.org/10.1101/2020.05.08.084327
Contact Info: Ravi Kumar Gandham: ravigandham@niab.org.in
URL: https://www.biorxiv.org/content/10.1101/2020.05.08.084327v4
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Unviersity of Hawaii, Bioqual, Inc., Soligenix, Inc.
Keywords: SARS-CoV-2, recombinant subunit protein vaccine, spike protein, immune response, pathology, primates
Summary of Study: A recombinant subunit protein forumulated with CoVaccine HT adjuvant induces superior immunity than natural infection and reduces viral load while protecting cynomolgus macaques from COVID-19-like disease caused by late SARS-CoV-2 P.1 (Gamma) challenge.
References: doi: 10.1101/2021.09.24.461759
Contact Info: Axel Lehrer: lehrer@hawaii.edu
URL: https://www.biorxiv.org/content/10.1101/2021.09.24.461759v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Unviersity of Hawaii, Bioqual, Inc., Soligenix, Inc.
Keywords: SARS-CoV-2, recombinant subunit protein vaccine, spike protein, immune response, pathology, primates
Summary of Study: A recombinant subunit protein forumulated with CoVaccine HT adjuvant induces superior immunity than natural infection and reduces viral load while protecting cynomolgus macaques from COVID-19-like disease caused by late SARS-CoV-2 P.1 (Gamma) challenge.
References: doi: 10.1101/2021.09.24.461759
Contact Info: Axel Lehrer: lehrer@hawaii.edu
URL: https://www.biorxiv.org/content/10.1101/2021.09.24.461759v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: Duke University School of Medicine
Keywords: SARS-CoV-2, neutralizing and infection-enhancing antibodies, mice and primates
Summary of Study: SARS-CoV-2 antibodies can mediate infection enhancement in vitro. However, this in vitro phenotype does not translate to enhanced infection in a non-human primate model of SARS-CoV-2 infection. These preclinical results indicate that SARS-CoV-2 antibody treatments or the induction of SARS-CoV-2 antibodies by vaccination have a low likelihood of exacerbating COVID-19 disease in humans.
References: doi: https://doi.org/10.1101/2020.12.31.424729
Contact Info: Barton Haynes: barton.haynes@duke.edu/Kevin Saunders: kevin.saunders@duke.edu
URL: https://www.biorxiv.org/content/10.1101/2020.12.31.424729v2
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: Duke University School of Medicine
Keywords: SARS-CoV-2, neutralizing and infection-enhancing antibodies, mice and primates
Summary of Study: SARS-CoV-2 antibodies can mediate infection enhancement in vitro. However, this in vitro phenotype does not translate to enhanced infection in a non-human primate model of SARS-CoV-2 infection. These preclinical results indicate that SARS-CoV-2 antibody treatments or the induction of SARS-CoV-2 antibodies by vaccination have a low likelihood of exacerbating COVID-19 disease in humans.
References: doi: https://doi.org/10.1101/2020.12.31.424729
Contact Info: Barton Haynes: barton.haynes@duke.edu/Kevin Saunders: kevin.saunders@duke.edu
URL: https://www.biorxiv.org/content/10.1101/2020.12.31.424729v2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: University of Pennsylvania
Keywords: SARS-CoV-2, vaccine, pseudovirus, neutralizing antibodies, mice, primates, humans
Summary of Study: SARs-CoV-2 recently mutated near the region targeted by many vaccines. The current study tested whether the mutation would hinder the ability of current vaccines to induce neutralizing antibodies in mice/NHPs/human serum. Their results indicate the viral mutation will not interfere with the effects of vaccines developed based on the original protein structure.
References: doi: 10.1101/2020.07.22.20159905
Contact Info: Drew Weissman, Email: Drew@pennmedicine.upenn.edu OR Davis Montefiori, email: david.montefiori@duke.edu
URL: https://www.medrxiv.org/content/10.1101/2020.07.22.20159905v2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: University of Pennsylvania
Keywords: SARS-CoV-2, vaccine, pseudovirus, neutralizing antibodies, mice, primates, humans
Summary of Study: SARs-CoV-2 recently mutated near the region targeted by many vaccines. The current study tested whether the mutation would hinder the ability of current vaccines to induce neutralizing antibodies in mice/NHPs/human serum. Their results indicate the viral mutation will not interfere with the effects of vaccines developed based on the original protein structure.
References: doi: 10.1101/2020.07.22.20159905
Contact Info: Drew Weissman, Email: Drew@pennmedicine.upenn.edu OR Davis Montefiori, email: david.montefiori@duke.edu
URL: https://www.medrxiv.org/content/10.1101/2020.07.22.20159905v2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Walter Reed National Military Medical Center; Bioqual; University of Pittsburgh Medical Center; Henry Jackson Foundation; Ragon Institute of MGH, MIT, and Harvard
Keywords: SARS-CoV-2, live oral vaccine, gastrointestinal tract, pathology, immune response, primates
Summary of Study: Post-pyloric inoculation of live SARS-CoV-2 is weakly immunogenic and confers partial protection against respiratory SARS-CoV-2 challenge in rhesus macaques.
References: doi: 10.1128/JVI.01599-21
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://journals.asm.org/doi/10.1128/JVI.01599-21?url_ver=Z39.88-2003&rfr_id=or…
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Walter Reed National Military Medical Center; Bioqual; University of Pittsburgh Medical Center; Henry Jackson Foundation; Ragon Institute of MGH, MIT, and Harvard
Keywords: SARS-CoV-2, live oral vaccine, gastrointestinal tract, pathology, immune response, primates
Summary of Study: Post-pyloric inoculation of live SARS-CoV-2 is weakly immunogenic and confers partial protection against respiratory SARS-CoV-2 challenge in rhesus macaques.
References: doi: 10.1128/JVI.01599-21
Contact Info: Dan Barouch: dbarouch@bidmc.harvard.edu
URL: https://journals.asm.org/doi/10.1128/JVI.01599-21?url_ver=Z39.88-2003&rfr_id=or…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID; Yerkes National Primate Research Center; Emory University School of Medicine; Bioqual; Moderna
Keywords: SARS-CoV-2, mRNA-vaccine, immune response, protection, virus reproduction, primates
Summary of Study: mRNA-1273 provided durable protection against B.1.617.2 challenge in the lower airways likely through anamnestic induction of antibody responses in the lung.
References: PMID: 34729558 / doi: 10.1101/2021.10.23.465542
Contact Info: Robert Seder: rseder@mail.nih.gov; Daniel Douek: ddouek@mail.nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.10.23.465542v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID; Yerkes National Primate Research Center; Emory University School of Medicine; Bioqual; Moderna
Keywords: SARS-CoV-2, mRNA-vaccine, immune response, protection, virus reproduction, primates
Summary of Study: mRNA-1273 provided durable protection against B.1.617.2 challenge in the lower airways likely through anamnestic induction of antibody responses in the lung.
References: PMID: 34729558 / doi: 10.1101/2021.10.23.465542
Contact Info: Robert Seder: rseder@mail.nih.gov; Daniel Douek: ddouek@mail.nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.10.23.465542v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan
Keywords: SARS-CoV-2, therapeutics, an iodine complex, primates
Summary of Study: Renessans, an iodine complex which has proven in vitro antiretroviral activity, may result in early clearance of SARS-CoV-2.
References: doi: https://doi.org/10.1101/2020.11.17.377432
Contact Info: Tahir Yaqub: tahiryaqub@uvas.edu.pk
URL: https://www.biorxiv.org/content/10.1101/2020.11.17.377432v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan
Keywords: SARS-CoV-2, therapeutics, an iodine complex, primates
Summary of Study: Renessans, an iodine complex which has proven in vitro antiretroviral activity, may result in early clearance of SARS-CoV-2.
References: doi: https://doi.org/10.1101/2020.11.17.377432
Contact Info: Tahir Yaqub: tahiryaqub@uvas.edu.pk
URL: https://www.biorxiv.org/content/10.1101/2020.11.17.377432v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID, Emory University, Duke University, Moderna, Bioqual
Keywords: SARS-CoV-2, mRNA vaccine, lipid nanoparticles, immune response, pathology, primates
Summary of Study: mRNA-1273 vaccine-induced antibody responses are a mechanistic correlate of protection against SARS-CoV-2 infection in NHP.
References: PMID: 33907752 / doi: 10.1101/2021.04.20.44067
Contact Info: Robert Seder: rseder@mail.nih.gov; Barney Graham: bgraham@nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.04.20.440647v2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID, Emory University, Duke University, Moderna, Bioqual
Keywords: SARS-CoV-2, mRNA vaccine, lipid nanoparticles, immune response, pathology, primates
Summary of Study: mRNA-1273 vaccine-induced antibody responses are a mechanistic correlate of protection against SARS-CoV-2 infection in NHP.
References: PMID: 33907752 / doi: 10.1101/2021.04.20.44067
Contact Info: Robert Seder: rseder@mail.nih.gov; Barney Graham: bgraham@nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.04.20.440647v2
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: University of Maryland School of Medicine; Noravax
Keywords: SARS-CoV-2, receptor-binding domain subunit vaccine, immune response, mice and primates
Summary of Study: Positive results in non-human primates suggest the feasibility of utilizing a B.1.351 Spike directed variant vaccine as a booster after previous immunization with a vaccine directed toward the ancestral SARS-CoV-2 Spike protein.
References: doi: 10.1101/2021.06.08.447631
Contact Info: Matthew Frieman: mfrieman@som.umaryland.edu
URL: https://www.biorxiv.org/content/10.1101/2021.06.08.447631v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: University of Maryland School of Medicine; Noravax
Keywords: SARS-CoV-2, receptor-binding domain subunit vaccine, immune response, mice and primates
Summary of Study: Positive results in non-human primates suggest the feasibility of utilizing a B.1.351 Spike directed variant vaccine as a booster after previous immunization with a vaccine directed toward the ancestral SARS-CoV-2 Spike protein.
References: doi: 10.1101/2021.06.08.447631
Contact Info: Matthew Frieman: mfrieman@som.umaryland.edu
URL: https://www.biorxiv.org/content/10.1101/2021.06.08.447631v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID, Emory University
Keywords: SARS-CoV-2, mRNA vaccine, virus genome variants, immune response, pathology, primates
Summary of Study: Immunization with two doses of mRNA-1273 achieves effective immunity that rapidly controls lower and upper airway viral replication against the B-1.351 variant in NHP.
References: PMID: 34075375 / doi: 10.1101/2021.05.21.445189
Contact Info: Barney Graham: bgraham@nih.gov; Robert Seder: rseder@mail.nih.gov;
URL: https://www.biorxiv.org/content/10.1101/2021.05.21.445189v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID, Emory University
Keywords: SARS-CoV-2, mRNA vaccine, virus genome variants, immune response, pathology, primates
Summary of Study: Immunization with two doses of mRNA-1273 achieves effective immunity that rapidly controls lower and upper airway viral replication against the B-1.351 variant in NHP.
References: PMID: 34075375 / doi: 10.1101/2021.05.21.445189
Contact Info: Barney Graham: bgraham@nih.gov; Robert Seder: rseder@mail.nih.gov;
URL: https://www.biorxiv.org/content/10.1101/2021.05.21.445189v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID; CureVac AG
Keywords: SARS-CoV-2, mRNA vaccine, immune response, primates
Summary of Study: Prime-boost vaccination with 4 ug of vaccine candidate CV07050101 resulted in limited immune responses in 4 out of 6 non-human primates.
References: doi: 10.1101/2021.07.07.451505
Contact Info: Vincent Munster: vincent.munster@nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.07.07.451505v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID; CureVac AG
Keywords: SARS-CoV-2, mRNA vaccine, immune response, primates
Summary of Study: Prime-boost vaccination with 4 ug of vaccine candidate CV07050101 resulted in limited immune responses in 4 out of 6 non-human primates.
References: doi: 10.1101/2021.07.07.451505
Contact Info: Vincent Munster: vincent.munster@nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.07.07.451505v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: National Institute of Allergy and
Infectious Diseases, National Institutes of Health; Washington National Primate Research Center, University of Washington; HDT Bio; Fred Hutchinson Cancer Research Center
Keywords: SARS-CoV-2, replicon RNA vaccine, neutralizing antibody response, pathology, primates
Summary of Study: A self-amplifying replicon RNA vaccine elicits protective immunity to COVID-19 and a strong protective response even after antibody levels decreased to undetectable levels.
References: PMID: 35982677 / doi: 10.1101/2022.08.08.503239
Contact Info: Deborah Heydenburg Fuller; Jesse H. Erasmus
URL: https://www.biorxiv.org/content/10.1101/2022.08.08.503239v1
NHP Species: pigtail macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: National Institute of Allergy and
Infectious Diseases, National Institutes of Health; Washington National Primate Research Center, University of Washington; HDT Bio; Fred Hutchinson Cancer Research Center
Keywords: SARS-CoV-2, replicon RNA vaccine, neutralizing antibody response, pathology, primates
Summary of Study: A self-amplifying replicon RNA vaccine elicits protective immunity to COVID-19 and a strong protective response even after antibody levels decreased to undetectable levels.
References: PMID: 35982677 / doi: 10.1101/2022.08.08.503239
Contact Info: Deborah Heydenburg Fuller; Jesse H. Erasmus
URL: https://www.biorxiv.org/content/10.1101/2022.08.08.503239v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: pathogenesis
NPRC/Institute: Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, United States; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Keywords: SARS-CoV-2, neutralizing antibodies, immune response, anatomic compartments, primates
Summary of Study: Compartment-Specific Antibody Correlates of Protection to SARS-CoV-2 Omicron
References: PMID: 38464001 PMCID: PMC10925337 DOI: 10.1101/2024.03.01.582951
Contact Info: Dan H. Barouch: dbarouch@bidmc.harvard.edu; Ryan McNamara: rpmcnamara@mgh.harvard.edu
URL: https://www.biorxiv.org/content/10.1101/2024.03.01.582951v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: pathogenesis
NPRC/Institute: Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, United States; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Keywords: SARS-CoV-2, neutralizing antibodies, immune response, anatomic compartments, primates
Summary of Study: Compartment-Specific Antibody Correlates of Protection to SARS-CoV-2 Omicron
References: PMID: 38464001 PMCID: PMC10925337 DOI: 10.1101/2024.03.01.582951
Contact Info: Dan H. Barouch: dbarouch@bidmc.harvard.edu; Ryan McNamara: rpmcnamara@mgh.harvard.edu
URL: https://www.biorxiv.org/content/10.1101/2024.03.01.582951v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets, howler monkeys
Year Published:
Study Type/Review:
NPRC/Institute: Instituto Federal do Norte de Minas Gerais, Brazil; Universidade de Brasilia; State University of Santa Cruz, and others
Keywords: SARS-CoV-2, wild animals, epidemiology, neotropical primates
Summary of Study: 51 neotropical NHPs were examined for serological and virological evidence of SARS-CoV-2 infections. No evidence of viral spillover into these populations was found.
References: doi: 10.1101/2021.06.17.448890
Contact Info: Danilo Bretas deOliveira: danilo.bretas@ufvjm.edu.br
URL: https://www.biorxiv.org/content/10.1101/2021.06.17.448890v1
NHP Species: marmosets, howler monkeys
Year Published:
Study Type/Review:
NPRC/Institute: Instituto Federal do Norte de Minas Gerais, Brazil; Universidade de Brasilia; State University of Santa Cruz, and others
Keywords: SARS-CoV-2, wild animals, epidemiology, neotropical primates
Summary of Study: 51 neotropical NHPs were examined for serological and virological evidence of SARS-CoV-2 infections. No evidence of viral spillover into these populations was found.
References: doi: 10.1101/2021.06.17.448890
Contact Info: Danilo Bretas deOliveira: danilo.bretas@ufvjm.edu.br
URL: https://www.biorxiv.org/content/10.1101/2021.06.17.448890v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published:
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center, Tulane University School of Medicine
Keywords: SARS-CoV-2, viral RNA, evolution, genomic variants, primates
Summary of Study: Study confirmed importance of an intact furin cleavage site for SARS-CoV-2 infection in vivo; a new SARS-CoV-2 strain exclusive to the African green monkey species was identified.
References: doi: 10.1101/2021.08.22.457295
Contact Info: Nicolas Maness: nmaness@tulane.edu
URL: https://www.biorxiv.org/content/10.1101/2021.08.22.457295v1.full
NHP Species: african green monkeys
Year Published:
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center, Tulane University School of Medicine
Keywords: SARS-CoV-2, viral RNA, evolution, genomic variants, primates
Summary of Study: Study confirmed importance of an intact furin cleavage site for SARS-CoV-2 infection in vivo; a new SARS-CoV-2 strain exclusive to the African green monkey species was identified.
References: doi: 10.1101/2021.08.22.457295
Contact Info: Nicolas Maness: nmaness@tulane.edu
URL: https://www.biorxiv.org/content/10.1101/2021.08.22.457295v1.full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: CureVac AG Tuebingen, Germany
Keywords: SARS-CoV-2, mRNA vaccine CVnCoV, safety, immunogenicity, and protective efficacy, primates
Summary of Study: The efficacy of CVnCoV, a lipid-nanoparticle encapsulated, sequence optimized mRNA-based SARS-CoV-2 vaccine was evaluated. The study demonstrates that CVnCoV induces robust humoral and cellular responses in non-human primates. These results demonstrate safety, immunogenicity, and protective efficacy of this vaccine that extend beyond previously published preclinical data and provide strong support for further clinical testing in ongoing phase 2b/3 efficacy studies.
References: doi: https://doi.org/10.1101/2020.12.23.424138
Contact Info: no contact information provided
URL: https://www.biorxiv.org/content/10.1101/2020.12.23.424138v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: CureVac AG Tuebingen, Germany
Keywords: SARS-CoV-2, mRNA vaccine CVnCoV, safety, immunogenicity, and protective efficacy, primates
Summary of Study: The efficacy of CVnCoV, a lipid-nanoparticle encapsulated, sequence optimized mRNA-based SARS-CoV-2 vaccine was evaluated. The study demonstrates that CVnCoV induces robust humoral and cellular responses in non-human primates. These results demonstrate safety, immunogenicity, and protective efficacy of this vaccine that extend beyond previously published preclinical data and provide strong support for further clinical testing in ongoing phase 2b/3 efficacy studies.
References: doi: https://doi.org/10.1101/2020.12.23.424138
Contact Info: no contact information provided
URL: https://www.biorxiv.org/content/10.1101/2020.12.23.424138v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Tulane NPRC
Keywords: SARS-CoV-2, immune response, primates
Summary of Study: Increased levels of monocytes and chemokines after infection is associated with viral load and disease severity
References: doi: https://doi.org/10.1101/2020.07.21.213777
Contact Info: Monica Vaccari, mvaccari@tulane.edu
URL: https://www.biorxiv.org/content/10.1101/2020.07.21.213777v1%20
NHP Species: african green monkeys, rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Tulane NPRC
Keywords: SARS-CoV-2, immune response, primates
Summary of Study: Increased levels of monocytes and chemokines after infection is associated with viral load and disease severity
References: doi: https://doi.org/10.1101/2020.07.21.213777
Contact Info: Monica Vaccari, mvaccari@tulane.edu
URL: https://www.biorxiv.org/content/10.1101/2020.07.21.213777v1%20
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Fred Hutchinson Cancer Research Center; University of Washington; Washington National Primate Research Center; HDT Bio; NIAID
Keywords: SARS-CoV-2, phage-based deep mutational scanning approach, spike protein, immune response, primates
Summary of Study: Antibody response to SARS-CoV-2 in macaques shares many features with humans, but with substantial differences in the recognition of certain epitopes and considerable individual variability in antibody escape profiles, suggesting a diverse repertoire of antibodies that can respond to major epitopes in both humans and macaques.
References: doi: 10.1101/2021.12.01.470697
Contact Info: Julie Overbaugh: joverbau@fredhutch.org
URL: https://www.biorxiv.org/content/10.1101/2021.12.01.470697v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Fred Hutchinson Cancer Research Center; University of Washington; Washington National Primate Research Center; HDT Bio; NIAID
Keywords: SARS-CoV-2, phage-based deep mutational scanning approach, spike protein, immune response, primates
Summary of Study: Antibody response to SARS-CoV-2 in macaques shares many features with humans, but with substantial differences in the recognition of certain epitopes and considerable individual variability in antibody escape profiles, suggesting a diverse repertoire of antibodies that can respond to major epitopes in both humans and macaques.
References: doi: 10.1101/2021.12.01.470697
Contact Info: Julie Overbaugh: joverbau@fredhutch.org
URL: https://www.biorxiv.org/content/10.1101/2021.12.01.470697v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NCI/NIH; BIOQUAL, Inc.; NIAID; Alchem Laboratories; Frederick National Laboratory for Cancer Research
Keywords: SARS-CoV-2, virus genomic variants, mucosal booster vaccine, immune response, primates
Summary of Study: Following SARS-CoV-2 beta variant challenge, NHPs that received one intranasal beta-variant booster demonstrated significant protection against viral replication in the upper and lower respiratory tracts, with almost full protection in the nasal cavity.
References: doi: 10.1101/2021.10.19.464990
Contact Info: Yongjun Sui: suiy@mail.nih.gov; Jay Berzofsky: berzofsj@mail.nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.10.19.464990v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NCI/NIH; BIOQUAL, Inc.; NIAID; Alchem Laboratories; Frederick National Laboratory for Cancer Research
Keywords: SARS-CoV-2, virus genomic variants, mucosal booster vaccine, immune response, primates
Summary of Study: Following SARS-CoV-2 beta variant challenge, NHPs that received one intranasal beta-variant booster demonstrated significant protection against viral replication in the upper and lower respiratory tracts, with almost full protection in the nasal cavity.
References: doi: 10.1101/2021.10.19.464990
Contact Info: Yongjun Sui: suiy@mail.nih.gov; Jay Berzofsky: berzofsj@mail.nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.10.19.464990v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: School of Biological Science and Medical Engineering, Beihang University, Beijing
Keywords: SARS-CoV-2, S-protein-based linear B-cell epitope candidates, several species
Summary of Study: Four top prioritized linear B-cell epitopes in the hotspot regions of S protein can specifically bind with serum antibodies from rhesus monkeys inoculated with different SARS-CoV-2 vaccine candidates or a patient recovering from COVID-19. This study suggests that the four linear B-cell epitopes are potentially important candidates for serological assay or vaccine development.
References: doi: https://doi.org/10.1101/2020.12.13.422550
Contact Info: Jing Zhang: jz2716@buaa.edu.cn/Hui Wang: geno0109@vip.sina.com
URL: https://www.biorxiv.org/content/10.1101/2020.12.13.422550v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: School of Biological Science and Medical Engineering, Beihang University, Beijing
Keywords: SARS-CoV-2, S-protein-based linear B-cell epitope candidates, several species
Summary of Study: Four top prioritized linear B-cell epitopes in the hotspot regions of S protein can specifically bind with serum antibodies from rhesus monkeys inoculated with different SARS-CoV-2 vaccine candidates or a patient recovering from COVID-19. This study suggests that the four linear B-cell epitopes are potentially important candidates for serological assay or vaccine development.
References: doi: https://doi.org/10.1101/2020.12.13.422550
Contact Info: Jing Zhang: jz2716@buaa.edu.cn/Hui Wang: geno0109@vip.sina.com
URL: https://www.biorxiv.org/content/10.1101/2020.12.13.422550v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Shenzhen Hospital, Southern Medical University, Shenzhen, China
Keywords: SARS-CoV-2, adenovirus vectored vaccines, immunization, primates
Summary of Study: Two novel adenovirus vectored COVID-19 vaccines were produced, which, when used in succession, elicited robust humoral and T-cell immune response to SARS-CoV-2 in mice and rhesus macaques. These two vaccines are being planned for clinical phase I/II trials after an extensive safety evaluation has been carried out in pre-clinical animal examination.
References: doi: https://doi.org/10.1101/2020.09.28.311480
Contact Info: Chengyao Li: chengyaoli@hotmail.com; Tingting L: aple-ting-007@163.com
URL: https://www.biorxiv.org/content/10.1101/2020.09.28.311480v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Shenzhen Hospital, Southern Medical University, Shenzhen, China
Keywords: SARS-CoV-2, adenovirus vectored vaccines, immunization, primates
Summary of Study: Two novel adenovirus vectored COVID-19 vaccines were produced, which, when used in succession, elicited robust humoral and T-cell immune response to SARS-CoV-2 in mice and rhesus macaques. These two vaccines are being planned for clinical phase I/II trials after an extensive safety evaluation has been carried out in pre-clinical animal examination.
References: doi: https://doi.org/10.1101/2020.09.28.311480
Contact Info: Chengyao Li: chengyaoli@hotmail.com; Tingting L: aple-ting-007@163.com
URL: https://www.biorxiv.org/content/10.1101/2020.09.28.311480v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: University of Texas Medical Branch, Galveston
Keywords: SARS-CoV-2, apoptosis in post-mortem lung, pathogenesis, primates
Summary of Study: Apoptosis was examined in post-mortem lung sections from COVID-19 patients and lung tissues from NHP models of SARS-CoV-2 infection. Multiple-target immunofluorescence assays and Western blotting suggest both intrinsic and extrinsic apoptotic pathways are activated during SARS-CoV-2 infection. These findings may help to delineate a novel insight into the pathogenesis of ARDS following SARS-CoV-2 infection.
References: PMID: 33398280/doi: 10.1101/2020.12.23.424254
Contact Info: Bin Gong: bigong@utmb.edu
URL: https://www.biorxiv.org/content/10.1101/2020.12.23.424254v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: University of Texas Medical Branch, Galveston
Keywords: SARS-CoV-2, apoptosis in post-mortem lung, pathogenesis, primates
Summary of Study: Apoptosis was examined in post-mortem lung sections from COVID-19 patients and lung tissues from NHP models of SARS-CoV-2 infection. Multiple-target immunofluorescence assays and Western blotting suggest both intrinsic and extrinsic apoptotic pathways are activated during SARS-CoV-2 infection. These findings may help to delineate a novel insight into the pathogenesis of ARDS following SARS-CoV-2 infection.
References: PMID: 33398280/doi: 10.1101/2020.12.23.424254
Contact Info: Bin Gong: bigong@utmb.edu
URL: https://www.biorxiv.org/content/10.1101/2020.12.23.424254v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: nanogen Pharmaceutical Biotechnology JSC
Keywords: SARS-CoV-2, vaccine candidate, receptor-binding domain, immune response, hamsters, mice, primates
Summary of Study: Nanocovax, a vaccine candidate based on recombinant protein production of the extracellular (soluble) portion of the S protein of SARS-CoV-2, induced high levels of S protein-specific IgG, as well as neutralizing antibody in three animal models (mice, Syrian hamsters, and Macaca leonina (Northern pig-tailed macaque).
References: doi: 10.1101/2021.07.20.453162
Contact Info: Do Minh Si: minhsi@nanogenpharma.com
URL: https://www.biorxiv.org/content/10.1101/2021.07.20.453162v1
NHP Species: pigtail macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: nanogen Pharmaceutical Biotechnology JSC
Keywords: SARS-CoV-2, vaccine candidate, receptor-binding domain, immune response, hamsters, mice, primates
Summary of Study: Nanocovax, a vaccine candidate based on recombinant protein production of the extracellular (soluble) portion of the S protein of SARS-CoV-2, induced high levels of S protein-specific IgG, as well as neutralizing antibody in three animal models (mice, Syrian hamsters, and Macaca leonina (Northern pig-tailed macaque).
References: doi: 10.1101/2021.07.20.453162
Contact Info: Do Minh Si: minhsi@nanogenpharma.com
URL: https://www.biorxiv.org/content/10.1101/2021.07.20.453162v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID, Emory University, Moderna
Keywords: SARS-CoV-2, mRNA vaccine, immune response, pathology, primates
Summary of Study: Immunization with two doses of mRNA-1273 achieves effective immunity that rapidly controls lower and upper airway viral replication against the B.1.351 variant in NHP.
References: doi: 10.1101/2021.05.21.445189
Contact Info: Barney Graham: bgraham@nih.gov; Robert Seder: rseder@mail.nih.gov;
URL: https://www.biorxiv.org/content/10.1101/2021.05.21.445189v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID, Emory University, Moderna
Keywords: SARS-CoV-2, mRNA vaccine, immune response, pathology, primates
Summary of Study: Immunization with two doses of mRNA-1273 achieves effective immunity that rapidly controls lower and upper airway viral replication against the B.1.351 variant in NHP.
References: doi: 10.1101/2021.05.21.445189
Contact Info: Barney Graham: bgraham@nih.gov; Robert Seder: rseder@mail.nih.gov;
URL: https://www.biorxiv.org/content/10.1101/2021.05.21.445189v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: MIT, Harvard Medical School, Vaccine Analytics and Formulation Center (Univ. of Kansas), Cummings School of Veterinary Medicine (Tufts Univ.), SpyBiotech Ltd., Bioqual, Bill & Melinda Gates Fdtn.
Keywords: SARS-CoV-2, protein subunit vaccine, manufacturing, preclinical testing, primates
Summary of Study: A modular protein subunit vaccine candidate elicits a strong immune response in cynomolgus macaques and protects against SARS-CoV-2 challenge. This vaccine candidate is currently being tested in clinical trials (ANZCTR Registration number ACTRN12620000817943).
References: PMID: 34282417 / doi: 10.1101/2021.07.13.452251
Contact Info: Dan Barouch: abarouch@bidmc.harvard.edu; J. Christopher Love: clove@mit.edu
URL: https://www.biorxiv.org/content/10.1101/2021.07.13.452251v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: MIT, Harvard Medical School, Vaccine Analytics and Formulation Center (Univ. of Kansas), Cummings School of Veterinary Medicine (Tufts Univ.), SpyBiotech Ltd., Bioqual, Bill & Melinda Gates Fdtn.
Keywords: SARS-CoV-2, protein subunit vaccine, manufacturing, preclinical testing, primates
Summary of Study: A modular protein subunit vaccine candidate elicits a strong immune response in cynomolgus macaques and protects against SARS-CoV-2 challenge. This vaccine candidate is currently being tested in clinical trials (ANZCTR Registration number ACTRN12620000817943).
References: PMID: 34282417 / doi: 10.1101/2021.07.13.452251
Contact Info: Dan Barouch: abarouch@bidmc.harvard.edu; J. Christopher Love: clove@mit.edu
URL: https://www.biorxiv.org/content/10.1101/2021.07.13.452251v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Harvard, MIT, Emory University School of Medicine, Yerkes National Primate Research Center and others
Keywords: SARS-CoV-2, adjuvanted soluble protein vaccine, binding and functional neutralization assays, serology, primates
Summary of Study: Antibodies induced by the AS03-adjuvanted preS dTM vaccine are sufficient to mediate protection against SARS-CoV-2 and support the evaluation of this vaccine in human clinical trials.
References: PMID: 33688652 / doi: 10.1101/2021.03.02.433390
Contact Info: Robert Seder: rseder@mail.nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.03.02.433390v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Harvard, MIT, Emory University School of Medicine, Yerkes National Primate Research Center and others
Keywords: SARS-CoV-2, adjuvanted soluble protein vaccine, binding and functional neutralization assays, serology, primates
Summary of Study: Antibodies induced by the AS03-adjuvanted preS dTM vaccine are sufficient to mediate protection against SARS-CoV-2 and support the evaluation of this vaccine in human clinical trials.
References: PMID: 33688652 / doi: 10.1101/2021.03.02.433390
Contact Info: Robert Seder: rseder@mail.nih.gov
URL: https://www.biorxiv.org/content/10.1101/2021.03.02.433390v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: ONPRC/YNPRC
Keywords: SARS-CoV-2, kinase inhibitor, primates
Summary of Study: Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques
References: doi: https://doi.org/10.1101/2020.09.16.300277
Contact Info: Dr. Mirko Paiardini; E-mail address: mirko.paiardini@emory.edu
URL: https://www.biorxiv.org/content/10.1101/2020.09.16.300277v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: ONPRC/YNPRC
Keywords: SARS-CoV-2, kinase inhibitor, primates
Summary of Study: Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques
References: doi: https://doi.org/10.1101/2020.09.16.300277
Contact Info: Dr. Mirko Paiardini; E-mail address: mirko.paiardini@emory.edu
URL: https://www.biorxiv.org/content/10.1101/2020.09.16.300277v1