Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NCI/NIH; BIOQUAL, Inc.; NIAID; Alchem Laboratories; Frederick National Laboratory for Cancer Research
Keywords: SARS-CoV-2, virus genomic variants, mucosal booster vaccine, immune response, primates
Summary of Study: Following SARS-CoV-2 beta variant challenge, NHPs that received one intranasal beta-variant booster demonstrated significant protection against viral replication in the upper and lower respiratory tracts, with almost full protection in the nasal cavity.
References: doi: 10.1101/2021.10.19.464990
Contact Info: Yongjun Sui: [email protected]; Jay Berzofsky: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.10.19.464990v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NCI/NIH; BIOQUAL, Inc.; NIAID; Alchem Laboratories; Frederick National Laboratory for Cancer Research
Keywords: SARS-CoV-2, virus genomic variants, mucosal booster vaccine, immune response, primates
Summary of Study: Following SARS-CoV-2 beta variant challenge, NHPs that received one intranasal beta-variant booster demonstrated significant protection against viral replication in the upper and lower respiratory tracts, with almost full protection in the nasal cavity.
References: doi: 10.1101/2021.10.19.464990
Contact Info: Yongjun Sui: [email protected]; Jay Berzofsky: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.10.19.464990v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; Henan Normal University; Guangzhou Medical University; Fudan University
Keywords: SARS-CoV-2, inflammation, lung pathology, immune response, primates
Summary of Study: SARS-CoV-2 triggers an immediate mast cell (MC) degranulation, which initiates the alveolar epithelial inflammation and disrupts the tight junction. MC stabilizers that block degranulation reduce virus-induced lung inflammation and injury.
References: doi: 10.1101/2021.06.24.449680
Contact Info: Jian-Hua Wang: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.06.24.449680v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; Henan Normal University; Guangzhou Medical University; Fudan University
Keywords: SARS-CoV-2, inflammation, lung pathology, immune response, primates
Summary of Study: SARS-CoV-2 triggers an immediate mast cell (MC) degranulation, which initiates the alveolar epithelial inflammation and disrupts the tight junction. MC stabilizers that block degranulation reduce virus-induced lung inflammation and injury.
References: doi: 10.1101/2021.06.24.449680
Contact Info: Jian-Hua Wang: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.06.24.449680v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre, The Netherlands; Amsterdam UMC; Utrecht University, and others
Keywords: SARS-CoV-2, brain inflammation, longitudinal positron emission tomography, neuropathology,primates
Summary of Study: SARS-CoV-2 causes brain inflammation and Lewy bodies, a hallmark for Parkinson, after an asymptomatic infection in macaques.
References: doi: 10.1101/2021.02.23.432474
Contact Info: Ingrid Philippens: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.02.23.432474v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre, The Netherlands; Amsterdam UMC; Utrecht University, and others
Keywords: SARS-CoV-2, brain inflammation, longitudinal positron emission tomography, neuropathology,primates
Summary of Study: SARS-CoV-2 causes brain inflammation and Lewy bodies, a hallmark for Parkinson, after an asymptomatic infection in macaques.
References: doi: 10.1101/2021.02.23.432474
Contact Info: Ingrid Philippens: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.02.23.432474v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Medicago, Inc.; Stanford University; Tulane University School of Medicine; McGill University
Keywords: SARS-CoV-2, plant-derived virus-like particle vaccine, immune response, pathology, primates
Summary of Study: Although a single dose of an unadjuvanted virus-like particle (VLP) bearing SARS-CoV-2 spike protein vaccine candidate stimulated humoral and cell-mediated immune responses, booster immunization (at 28 days after prime) and adjuvants significantly improved both responses with a higher immunogenicity and protection provided by AS03 adjuvanted CoVLP.
References: doi: 10.1101.2021.05.15.444262
Contact Info: Nathalie Landry: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.05.15.444262v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Medicago, Inc.; Stanford University; Tulane University School of Medicine; McGill University
Keywords: SARS-CoV-2, plant-derived virus-like particle vaccine, immune response, pathology, primates
Summary of Study: Although a single dose of an unadjuvanted virus-like particle (VLP) bearing SARS-CoV-2 spike protein vaccine candidate stimulated humoral and cell-mediated immune responses, booster immunization (at 28 days after prime) and adjuvants significantly improved both responses with a higher immunogenicity and protection provided by AS03 adjuvanted CoVLP.
References: doi: 10.1101.2021.05.15.444262
Contact Info: Nathalie Landry: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.05.15.444262v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Laboratory of Virology (NIAID/NIH), Rocky Mountain Veterinary Branch (NIAID/NIH), CureVac AG
Keywords: SARS-CoV-2, mRNA vaccine candidate, humoral and cellular immune responses, primates
Summary of Study: A new SARS-CoV-2 S mRNA vaccine, CV07050101 was investigated in NHPs. Prime-boost vaccination of rhesus macaques with 4 ug of CV07050101 does not elicit a uniform nor robust immune response; however, vaccination using 8 ug of the same vaccine demonstrated protection.
References: PMID: 34268507 / doi: 10.1101/202.07.07.451505
Contact Info: Vincent Munster: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.07.07.451505v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Laboratory of Virology (NIAID/NIH), Rocky Mountain Veterinary Branch (NIAID/NIH), CureVac AG
Keywords: SARS-CoV-2, mRNA vaccine candidate, humoral and cellular immune responses, primates
Summary of Study: A new SARS-CoV-2 S mRNA vaccine, CV07050101 was investigated in NHPs. Prime-boost vaccination of rhesus macaques with 4 ug of CV07050101 does not elicit a uniform nor robust immune response; however, vaccination using 8 ug of the same vaccine demonstrated protection.
References: PMID: 34268507 / doi: 10.1101/202.07.07.451505
Contact Info: Vincent Munster: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.07.07.451505v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan
Keywords: SARS-CoV-2, therapeutics, an iodine complex, primates
Summary of Study: Renessans, an iodine complex which has proven in vitro antiretroviral activity, may result in early clearance of SARS-CoV-2.
References: doi: https://doi.org/10.1101/2020.11.17.377432
Contact Info: Tahir Yaqub: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.11.17.377432v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan
Keywords: SARS-CoV-2, therapeutics, an iodine complex, primates
Summary of Study: Renessans, an iodine complex which has proven in vitro antiretroviral activity, may result in early clearance of SARS-CoV-2.
References: doi: https://doi.org/10.1101/2020.11.17.377432
Contact Info: Tahir Yaqub: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.11.17.377432v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: University of Tokyo, Daichi Sankyo Col, Shiga University of Medical science, and others
Keywords: SARS-CoV-2, lipid nanoparticle-based mRNA vaccine candidate, immunogenicity, primates
Summary of Study: Macaques administered with LNP-mRNA targeting RBD acquired significantly high levels of protective IgG specific to SARS-CoV-2 in mucosal swab samples from conjunctiva, oral cavity, nasal cavity, trachea, bronchus, and rectum.
References: doi: 10.1101/2021.03.04.433852
Contact Info: Ken Ishii: [email protected]; Yoshihiro Kawaoka: [email protected]; Fumihiko Takeshita: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.03.04.433852v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: University of Tokyo, Daichi Sankyo Col, Shiga University of Medical science, and others
Keywords: SARS-CoV-2, lipid nanoparticle-based mRNA vaccine candidate, immunogenicity, primates
Summary of Study: Macaques administered with LNP-mRNA targeting RBD acquired significantly high levels of protective IgG specific to SARS-CoV-2 in mucosal swab samples from conjunctiva, oral cavity, nasal cavity, trachea, bronchus, and rectum.
References: doi: 10.1101/2021.03.04.433852
Contact Info: Ken Ishii: [email protected]; Yoshihiro Kawaoka: [email protected]; Fumihiko Takeshita: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.03.04.433852v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: Nat'l Institute of Infectious Diseases, Tokyo; University of Tokyo; Kumamoto University
Keywords: SARS-CoV-2, T cells, immune response, primates
Summary of Study: Study showed that subacute SARS-CoV-2 replication can be controlled even in the absence of CD8+ T cells. In SARS-CoV-2 infection, CD8+ T-cell responses may contribute to viral control, but these results suggest that CD8+ T-cell dysfunction does not solely lead to viral control failure or disease progression.
References: doi: 10.1101/2021.05.26.445769
Contact Info: Tesuro Matano: [email protected]; Takushi Nomura: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.05.26.445769v1
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: Nat'l Institute of Infectious Diseases, Tokyo; University of Tokyo; Kumamoto University
Keywords: SARS-CoV-2, T cells, immune response, primates
Summary of Study: Study showed that subacute SARS-CoV-2 replication can be controlled even in the absence of CD8+ T cells. In SARS-CoV-2 infection, CD8+ T-cell responses may contribute to viral control, but these results suggest that CD8+ T-cell dysfunction does not solely lead to viral control failure or disease progression.
References: doi: 10.1101/2021.05.26.445769
Contact Info: Tesuro Matano: [email protected]; Takushi Nomura: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.05.26.445769v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: National Cancer Institute/NIH; BIOQUAL; University of Athens; University of Washington
Keywords: SARS-CoV-2, DNA-based vaccine, immune response, primates
Summary of Study: A vaccine regimen comprising simultaneous co-immunization of DNA and Protein at the same anatomical site showed best neutralizing abilities and was more effective than DNA alone in inducing protective immune responses and controlling SARS-CoV-2 infection.
References: doi: 10.1101/2021.06.11.448032
Contact Info: Barbara Felber: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.06.11.448032v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: National Cancer Institute/NIH; BIOQUAL; University of Athens; University of Washington
Keywords: SARS-CoV-2, DNA-based vaccine, immune response, primates
Summary of Study: A vaccine regimen comprising simultaneous co-immunization of DNA and Protein at the same anatomical site showed best neutralizing abilities and was more effective than DNA alone in inducing protective immune responses and controlling SARS-CoV-2 infection.
References: doi: 10.1101/2021.06.11.448032
Contact Info: Barbara Felber: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.06.11.448032v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Pasteur Institute of Iran; University of Tehran; Biosunpharmed Co, Tehran; and others
Keywords: SARS-CoV-2, inactivated whole-virus vaccine, immune response, mice, guinea pig, rabbit and primates
Summary of Study: COVIran Barekat, an inactivated whole-virus SARS-CoV-2 candidate vaccine, elicited a high level of SARS-CoV-2 specific neutralizing antibodies in mice, rabbits, and rhesus macaques.
References: doi: 10.1101/2021.06.10.44.447951
Contact Info: Reza Aalizadeh: [email protected]; Hasan Jalili: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.06.10.447951v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Pasteur Institute of Iran; University of Tehran; Biosunpharmed Co, Tehran; and others
Keywords: SARS-CoV-2, inactivated whole-virus vaccine, immune response, mice, guinea pig, rabbit and primates
Summary of Study: COVIran Barekat, an inactivated whole-virus SARS-CoV-2 candidate vaccine, elicited a high level of SARS-CoV-2 specific neutralizing antibodies in mice, rabbits, and rhesus macaques.
References: doi: 10.1101/2021.06.10.44.447951
Contact Info: Reza Aalizadeh: [email protected]; Hasan Jalili: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.06.10.447951v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published:
Study Type/Review:
NPRC/Institute: Laboratory of Virology; NIAID/NIH; University of Plymouth; The Vaccine Group, Ltd.
Keywords: SARS-CoV-2, intranasal infection, genome variants, immune response, primates
Summary of Study: UK B.1.1.7 infection of African green monkeys exhibits increased respiratory replication and shedding but no disease enhancement.
References: PMID: 34159332 / doi: 10.1101/2021.06.11.448134
Contact Info: Heinz Feldmann: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.06.11.448134v1
NHP Species: african green monkeys
Year Published:
Study Type/Review:
NPRC/Institute: Laboratory of Virology; NIAID/NIH; University of Plymouth; The Vaccine Group, Ltd.
Keywords: SARS-CoV-2, intranasal infection, genome variants, immune response, primates
Summary of Study: UK B.1.1.7 infection of African green monkeys exhibits increased respiratory replication and shedding but no disease enhancement.
References: PMID: 34159332 / doi: 10.1101/2021.06.11.448134
Contact Info: Heinz Feldmann: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.06.11.448134v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: School of Biological Science and Medical Engineering, Beihang University, Beijing
Keywords: SARS-CoV-2, S-protein-based linear B-cell epitope candidates, several species
Summary of Study: Four top prioritized linear B-cell epitopes in the hotspot regions of S protein can specifically bind with serum antibodies from rhesus monkeys inoculated with different SARS-CoV-2 vaccine candidates or a patient recovering from COVID-19. This study suggests that the four linear B-cell epitopes are potentially important candidates for serological assay or vaccine development.
References: doi: https://doi.org/10.1101/2020.12.13.422550
Contact Info: Jing Zhang: [email protected]/Hui Wang: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.12.13.422550v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: School of Biological Science and Medical Engineering, Beihang University, Beijing
Keywords: SARS-CoV-2, S-protein-based linear B-cell epitope candidates, several species
Summary of Study: Four top prioritized linear B-cell epitopes in the hotspot regions of S protein can specifically bind with serum antibodies from rhesus monkeys inoculated with different SARS-CoV-2 vaccine candidates or a patient recovering from COVID-19. This study suggests that the four linear B-cell epitopes are potentially important candidates for serological assay or vaccine development.
References: doi: https://doi.org/10.1101/2020.12.13.422550
Contact Info: Jing Zhang: [email protected]/Hui Wang: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.12.13.422550v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: University of Liverpool, Public Health England, University of Bristol, and others
Keywords: SARS-CoV-2, the leader-transcriptional regulatory sequence gene junction, high resolution sequencing, primates
Summary of Study: LeTRS, a bioinformatics tool, identified known leader-TRS-junctions and identified novel species that were common across different species. The data indicated multi-phasic abundance of sgmRNAs in two different NHP models, with spikes in sgmRNA abundance reflected in human samples, and therefore has implications for transmission models and nucleic acid-based diagnostics.
References: doi: 10.1101/2021.03.03.433753
Contact Info: Julian Hiscox: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.03.03.433753v2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: University of Liverpool, Public Health England, University of Bristol, and others
Keywords: SARS-CoV-2, the leader-transcriptional regulatory sequence gene junction, high resolution sequencing, primates
Summary of Study: LeTRS, a bioinformatics tool, identified known leader-TRS-junctions and identified novel species that were common across different species. The data indicated multi-phasic abundance of sgmRNAs in two different NHP models, with spikes in sgmRNA abundance reflected in human samples, and therefore has implications for transmission models and nucleic acid-based diagnostics.
References: doi: 10.1101/2021.03.03.433753
Contact Info: Julian Hiscox: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.03.03.433753v2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Rocky Mountain Laboratories/NIAID/NIH, University of Colorado School of Medicine
Keywords: SARS-CoV-2, T cells, immune response, pathology, primates
Summary of Study: T-cells play a role in the recovery of rhesus macaques from acute SARS-CoV-2 infections, although their depletion does not induce severe disease, and T cells do not account for the natural resistance of rhesus macaques to severed COVID-19. Neither primed CD4+ or CD8+ T cells appeared critical for immunoglobulin class switching, the development of immunological memory or protection from a second infection.
References: PMID: 33821272 / doi: 10.1101/2021.04.02.438262
Contact Info: Kim Hasenkrug: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.04.02.438262v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Rocky Mountain Laboratories/NIAID/NIH, University of Colorado School of Medicine
Keywords: SARS-CoV-2, T cells, immune response, pathology, primates
Summary of Study: T-cells play a role in the recovery of rhesus macaques from acute SARS-CoV-2 infections, although their depletion does not induce severe disease, and T cells do not account for the natural resistance of rhesus macaques to severed COVID-19. Neither primed CD4+ or CD8+ T cells appeared critical for immunoglobulin class switching, the development of immunological memory or protection from a second infection.
References: PMID: 33821272 / doi: 10.1101/2021.04.02.438262
Contact Info: Kim Hasenkrug: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.04.02.438262v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, marmosets
Year Published:
Study Type/Review:
NPRC/Institute: Department of Computational Medicine and Bioinformatics, University of Michigan
Keywords: SARS-CoV-2, a computational pipeline, the binding affinity ACE2, mammals, birds, fish, reptiles, and amphibians
Summary of Study: Identifying zoonotic origin of SARS-CoV-2 by modeling the binding affinity between Spike receptor-binding domain and host ACE2
References: doi: 10.1101/2020.09.11.293449
Contact Info: Yang Zhang: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.09.11.293449v1
NHP Species: rhesus macaques, marmosets
Year Published:
Study Type/Review:
NPRC/Institute: Department of Computational Medicine and Bioinformatics, University of Michigan
Keywords: SARS-CoV-2, a computational pipeline, the binding affinity ACE2, mammals, birds, fish, reptiles, and amphibians
Summary of Study: Identifying zoonotic origin of SARS-CoV-2 by modeling the binding affinity between Spike receptor-binding domain and host ACE2
References: doi: 10.1101/2020.09.11.293449
Contact Info: Yang Zhang: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.09.11.293449v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published:
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center, Tulane University School of Medicine
Keywords: SARS-CoV-2, viral RNA, evolution, genomic variants, primates
Summary of Study: Study confirmed importance of an intact furin cleavage site for SARS-CoV-2 infection in vivo; a new SARS-CoV-2 strain exclusive to the African green monkey species was identified.
References: doi: 10.1101/2021.08.22.457295
Contact Info: Nicolas Maness: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.08.22.457295v1.full
NHP Species: african green monkeys
Year Published:
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center, Tulane University School of Medicine
Keywords: SARS-CoV-2, viral RNA, evolution, genomic variants, primates
Summary of Study: Study confirmed importance of an intact furin cleavage site for SARS-CoV-2 infection in vivo; a new SARS-CoV-2 strain exclusive to the African green monkey species was identified.
References: doi: 10.1101/2021.08.22.457295
Contact Info: Nicolas Maness: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.08.22.457295v1.full
Coronavirus Investigated: SARS-CoV-2
NHP Species: lemurs, lorises
Year Published:
Study Type/Review:
NPRC/Institute: Univ. of Calgary, Institut de Biologia Evolutiva, New York Univ., and others
Keywords: SARS-CoV-2, ACE2 gene and protein sequences, several species, primates
Summary of Study: Susceptibility to SARS-CoV-2 is not equal across non-human primates. This study suggests that several clades of lemurs have a high potential susceptibility to SARS-CoV-2 infection. As they are among the primates at highest risk of extinction globally, further understanding of their risk should be a conservation priority. All feasible actions should be taken to limit their exposure to SARS-CoV-2.
References: PMID: 33564767 / doi: 10.1101/2021.02.03.429540
Contact Info: James Higham: [email protected]; Amanda Melin: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.02.03.429540v1
NHP Species: lemurs, lorises
Year Published:
Study Type/Review:
NPRC/Institute: Univ. of Calgary, Institut de Biologia Evolutiva, New York Univ., and others
Keywords: SARS-CoV-2, ACE2 gene and protein sequences, several species, primates
Summary of Study: Susceptibility to SARS-CoV-2 is not equal across non-human primates. This study suggests that several clades of lemurs have a high potential susceptibility to SARS-CoV-2 infection. As they are among the primates at highest risk of extinction globally, further understanding of their risk should be a conservation priority. All feasible actions should be taken to limit their exposure to SARS-CoV-2.
References: PMID: 33564767 / doi: 10.1101/2021.02.03.429540
Contact Info: James Higham: [email protected]; Amanda Melin: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.02.03.429540v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: SL VaxiGen Inc., Genexine Inc., Sorea Bio Park, Scongnam, Republic of Korea
Keywords: SARS-CoV-2, DNA-based vaccine candidate, GX-19, immunization, primates
Summary of Study: Vaccination with vaccine candidate GX-19 elicits a concurrent humoral response and Th1-biased immune responses in both mice and non-human primate models. In NHPs this response includes neutralizing antibodies that provide potent protective efficacy against SARS-CoV-2 infection.
References: doi: https://doi.org/10.1101/2020.10.09.334136
Contact Info: Young Chul Sung: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.10.09.334136v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: SL VaxiGen Inc., Genexine Inc., Sorea Bio Park, Scongnam, Republic of Korea
Keywords: SARS-CoV-2, DNA-based vaccine candidate, GX-19, immunization, primates
Summary of Study: Vaccination with vaccine candidate GX-19 elicits a concurrent humoral response and Th1-biased immune responses in both mice and non-human primate models. In NHPs this response includes neutralizing antibodies that provide potent protective efficacy against SARS-CoV-2 infection.
References: doi: https://doi.org/10.1101/2020.10.09.334136
Contact Info: Young Chul Sung: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.10.09.334136v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Shanghai Jemincare Pharmaceuticals, Wuhan Institute of Virology, and others
Keywords: SARS-CoV-2, antivirus antibodies, prophylactic and potent therapeutic efficacy, primates
Summary of Study: Antibody JMB2002 demonstrated complete prophylactic and potent therapeutic efficacy in a rhesus macaque disease model.
References: doi: 10.1101/2021.02.07.429299
Contact Info: Wuxiang Guan: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.02.07.429299v2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Shanghai Jemincare Pharmaceuticals, Wuhan Institute of Virology, and others
Keywords: SARS-CoV-2, antivirus antibodies, prophylactic and potent therapeutic efficacy, primates
Summary of Study: Antibody JMB2002 demonstrated complete prophylactic and potent therapeutic efficacy in a rhesus macaque disease model.
References: doi: 10.1101/2021.02.07.429299
Contact Info: Wuxiang Guan: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.02.07.429299v2
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: CureVac AG; Ragon Institute of MGH, MIT and Harvard; Harvard Medical School
Keywords: SARS-CoV-2, mRNA vaccine, immunogenicity and protective efficacy, immune response, primates
Summary of Study: Optimization of non-coding regions can greatly improve the immunogenicity and protective efficacy of a non-modified mRNA SARS-CoV-2 vaccine in macaques. Improved characteristics of CV2CoV, compared with CVnCoV, may translate into increased efficacy in humans, and clinical trials of CV2C0V are planned.
References: doi: 10.1038/s41586-021-04231-6
Contact Info: Susanne Rauch: [email protected]; Daniel Barouch: [email protected]
URL: https://www.nature.com/articles/s41586-021-04231-6
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: CureVac AG; Ragon Institute of MGH, MIT and Harvard; Harvard Medical School
Keywords: SARS-CoV-2, mRNA vaccine, immunogenicity and protective efficacy, immune response, primates
Summary of Study: Optimization of non-coding regions can greatly improve the immunogenicity and protective efficacy of a non-modified mRNA SARS-CoV-2 vaccine in macaques. Improved characteristics of CV2CoV, compared with CVnCoV, may translate into increased efficacy in humans, and clinical trials of CV2C0V are planned.
References: doi: 10.1038/s41586-021-04231-6
Contact Info: Susanne Rauch: [email protected]; Daniel Barouch: [email protected]
URL: https://www.nature.com/articles/s41586-021-04231-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Scripps Research Institute; MIT; UCSD; Howard Hughes Medican Institute
Keywords: SARS-CoV-2, receptor-binding domain vaccine, structural studies, immune response, primates
Summary of Study: Broadly neutralizing antibodies to an unappreciated site of conservation in the RBD in SARS-related viruses can be readily induced in rhesus macaques because of distinct properties of the naive macaque B cell repertoire that suggest prudence in the use of the macaque model in SARS vaccine evaluation and design.
References: doi: 10.1101/2021.07.05.451222
Contact Info: Ian Wilson: [email protected]; Dennis Burton: [email protected]; Raiees Andrabi: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.07.05.451222v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Scripps Research Institute; MIT; UCSD; Howard Hughes Medican Institute
Keywords: SARS-CoV-2, receptor-binding domain vaccine, structural studies, immune response, primates
Summary of Study: Broadly neutralizing antibodies to an unappreciated site of conservation in the RBD in SARS-related viruses can be readily induced in rhesus macaques because of distinct properties of the naive macaque B cell repertoire that suggest prudence in the use of the macaque model in SARS vaccine evaluation and design.
References: doi: 10.1101/2021.07.05.451222
Contact Info: Ian Wilson: [email protected]; Dennis Burton: [email protected]; Raiees Andrabi: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.07.05.451222v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre (BPRC), Rijswijk, The Netherlands
Keywords: SARS-CoV-2, post-acute phase, pulmonary disease, primates
Summary of Study: Study provides a detailed description of the pathogenesis of a low-passage SARS-CoV-2 isolate in two macaque species (rhesus and cynomolgus) and suggests both species represent an equally good model for COVID-19 prophylactic and therapeutic treatments.
References: doi: https://doi.org/10.1101/2020.11.05.369413
Contact Info: Ernst. J. Verschoor: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.11.05.369413v2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre (BPRC), Rijswijk, The Netherlands
Keywords: SARS-CoV-2, post-acute phase, pulmonary disease, primates
Summary of Study: Study provides a detailed description of the pathogenesis of a low-passage SARS-CoV-2 isolate in two macaque species (rhesus and cynomolgus) and suggests both species represent an equally good model for COVID-19 prophylactic and therapeutic treatments.
References: doi: https://doi.org/10.1101/2020.11.05.369413
Contact Info: Ernst. J. Verschoor: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.11.05.369413v2
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: Duke NUS Medical School, Singapore; Duke University Medical School
Keywords: SARS-CoV-2, lung inflammation, pathology, mice and primates
Summary of Study: Widespread degranulation of mast cells (MCs) during acute and unresolved airway inflammation in SARS-CoV-2-infected mice and non-human primates supports the association of MC activation with severe COVID-19 and suggests potential strategies for intervention.
References: PMID: 34100020 / doi: 10.1101.2021.05.31.21255594
Contact Info: Ashley St. John: [email protected]
URL: https://www.medrxiv.org/content/10.1101/2021.05.31.21255594v1
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: Duke NUS Medical School, Singapore; Duke University Medical School
Keywords: SARS-CoV-2, lung inflammation, pathology, mice and primates
Summary of Study: Widespread degranulation of mast cells (MCs) during acute and unresolved airway inflammation in SARS-CoV-2-infected mice and non-human primates supports the association of MC activation with severe COVID-19 and suggests potential strategies for intervention.
References: PMID: 34100020 / doi: 10.1101.2021.05.31.21255594
Contact Info: Ashley St. John: [email protected]
URL: https://www.medrxiv.org/content/10.1101/2021.05.31.21255594v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Pathogen and Biosecurity, Beijing, China
Keywords: SARS-CoV-2, recombinant subunit vaccine, neutralization potency, aged animals, primates
Summary of Study: Authors developed a pilot scale pipeline producing a recombinant subunit vaccine (RBD-Fc Vacc) with Receptor Binding Domain of SARS-CoV-2S protein fused with the Fc domain of human IgG1. This vaccine induced SARS-CoV-2 specific neutralizing antibodies in non-human primates and human ACE2 transgenic mice and is currently being assessed in randomized controlled phase I/II human clinical trials.
References: doi: https://doi.org/10.1101/2020.11.29.402339
Contact Info: Yuwei Gao: [email protected]; Wenjin Wei: [email protected]; Zhonghu Hu: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.11.29.402339v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Pathogen and Biosecurity, Beijing, China
Keywords: SARS-CoV-2, recombinant subunit vaccine, neutralization potency, aged animals, primates
Summary of Study: Authors developed a pilot scale pipeline producing a recombinant subunit vaccine (RBD-Fc Vacc) with Receptor Binding Domain of SARS-CoV-2S protein fused with the Fc domain of human IgG1. This vaccine induced SARS-CoV-2 specific neutralizing antibodies in non-human primates and human ACE2 transgenic mice and is currently being assessed in randomized controlled phase I/II human clinical trials.
References: doi: https://doi.org/10.1101/2020.11.29.402339
Contact Info: Yuwei Gao: [email protected]; Wenjin Wei: [email protected]; Zhonghu Hu: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.11.29.402339v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Shenzhen Hospital, Southern Medical University, Shenzhen, China
Keywords: SARS-CoV-2, adenovirus vectored vaccines, immunization, primates
Summary of Study: Two novel adenovirus vectored COVID-19 vaccines were produced, which, when used in succession, elicited robust humoral and T-cell immune response to SARS-CoV-2 in mice and rhesus macaques. These two vaccines are being planned for clinical phase I/II trials after an extensive safety evaluation has been carried out in pre-clinical animal examination.
References: doi: https://doi.org/10.1101/2020.09.28.311480
Contact Info: Chengyao Li: [email protected]; Tingting L: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.09.28.311480v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Shenzhen Hospital, Southern Medical University, Shenzhen, China
Keywords: SARS-CoV-2, adenovirus vectored vaccines, immunization, primates
Summary of Study: Two novel adenovirus vectored COVID-19 vaccines were produced, which, when used in succession, elicited robust humoral and T-cell immune response to SARS-CoV-2 in mice and rhesus macaques. These two vaccines are being planned for clinical phase I/II trials after an extensive safety evaluation has been carried out in pre-clinical animal examination.
References: doi: https://doi.org/10.1101/2020.09.28.311480
Contact Info: Chengyao Li: [email protected]; Tingting L: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.09.28.311480v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: Inserm, CEA, Paris, France; University of Amsterdam; and others
Keywords: SARS-CoV-2, prophylactic and therapeutic effect of COVA1-18 in vivo, several species, primates
Summary of Study: COVA1-18, a neutralizing antibody isolated from a convalescent patient and highly potent against the B.1.1.7 isolate, had very strong antiviral activity in the upper respiratory compartments of cynomolgus macaques, with an estimated reduction in viral infectivity of more than 95%, and prevented lymphopenia and extensive lung lesions.
References: PMID: 33619476 / doi: 10.21203/rs.3.rs-235272/v1
Contact Info: Roger LeGrand: [email protected]; MJ Van Gils: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899470/pdf/nihpp-rs235272v1.pdf
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: Inserm, CEA, Paris, France; University of Amsterdam; and others
Keywords: SARS-CoV-2, prophylactic and therapeutic effect of COVA1-18 in vivo, several species, primates
Summary of Study: COVA1-18, a neutralizing antibody isolated from a convalescent patient and highly potent against the B.1.1.7 isolate, had very strong antiviral activity in the upper respiratory compartments of cynomolgus macaques, with an estimated reduction in viral infectivity of more than 95%, and prevented lymphopenia and extensive lung lesions.
References: PMID: 33619476 / doi: 10.21203/rs.3.rs-235272/v1
Contact Info: Roger LeGrand: [email protected]; MJ Van Gils: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899470/pdf/nihpp-rs235272v1.pdf
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Tulane NPRC, Yerkes NPRC, New Iberia Research Center, Stanford
Keywords: SARS-CoV-2, subunit nanoparticle vaccine, primates
Summary of Study: These data reveal the promising performance of several adjuvants including AS03 and CpG 1018 (with Alum), which have been used in licensed vaccines, when used in conjunction with the SARS-CoV-2 RBD-NP immunogen.
References: PMID: 33594366 / doi: 10.1101/2021.02.10.430696
Contact Info: Bali Pulendran: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.02.10.430696v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Tulane NPRC, Yerkes NPRC, New Iberia Research Center, Stanford
Keywords: SARS-CoV-2, subunit nanoparticle vaccine, primates
Summary of Study: These data reveal the promising performance of several adjuvants including AS03 and CpG 1018 (with Alum), which have been used in licensed vaccines, when used in conjunction with the SARS-CoV-2 RBD-NP immunogen.
References: PMID: 33594366 / doi: 10.1101/2021.02.10.430696
Contact Info: Bali Pulendran: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.02.10.430696v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: CAS Key Laboratory of Infection and Immunity, Beijing, China
Keywords: SARS-CoV-2, therapeutics, human monoclonal antibody, primates
Summary of Study: The authors identify and characterize a potent human monoclonal antibody, HB27, that blocks SARS-CoV-2 attachment to its cellular receptor at sub-nM concentrations. Rhesus macaques showed no obvious adverse events when they received a 10-fold effective dose. These results suggest that HB27 is a promising candidate for COVID-19 immuno-therapies.
References: doi:Â https://doi.org/10.1101/2020.11.24.393629
Contact Info: Xiangxi Wang: [email protected]; Cheng-Feng Qin: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.11.24.393629v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: CAS Key Laboratory of Infection and Immunity, Beijing, China
Keywords: SARS-CoV-2, therapeutics, human monoclonal antibody, primates
Summary of Study: The authors identify and characterize a potent human monoclonal antibody, HB27, that blocks SARS-CoV-2 attachment to its cellular receptor at sub-nM concentrations. Rhesus macaques showed no obvious adverse events when they received a 10-fold effective dose. These results suggest that HB27 is a promising candidate for COVID-19 immuno-therapies.
References: doi:Â https://doi.org/10.1101/2020.11.24.393629
Contact Info: Xiangxi Wang: [email protected]; Cheng-Feng Qin: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.11.24.393629v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, pigtail macaques
Year Published:
Study Type/Review:
NPRC/Institute: National Institute of Animal Biotechnology, Telangana, India
Keywords: SARS-CoV-2, ACE2 receptor of various species, several species.
Summary of Study: The interaction of SARS-CoV-2 spike receptor-binding domain with its receptor (ACE2) in different hosts was evaluated to understand and predict viral entry. Most of the species considered in this study showed high probability of viral entry and should be followed to determine their ability to act as carriers and/or disseminators.
References: doi: https://doi.org/10.1101/2020.05.08.084327
Contact Info: Ravi Kumar Gandham: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.05.08.084327v4
NHP Species: rhesus macaques, pigtail macaques
Year Published:
Study Type/Review:
NPRC/Institute: National Institute of Animal Biotechnology, Telangana, India
Keywords: SARS-CoV-2, ACE2 receptor of various species, several species.
Summary of Study: The interaction of SARS-CoV-2 spike receptor-binding domain with its receptor (ACE2) in different hosts was evaluated to understand and predict viral entry. Most of the species considered in this study showed high probability of viral entry and should be followed to determine their ability to act as carriers and/or disseminators.
References: doi: https://doi.org/10.1101/2020.05.08.084327
Contact Info: Ravi Kumar Gandham: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.05.08.084327v4
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: NIAID/NIH; The Jenner Institute at the University of Oxford
Keywords: SARS-CoV-2, multiomics profiling, young and old animals, immune response, primates
Summary of Study: Despite similar disease outcomes, multi-omics profiling in SARS-CoV-2-infected rhesus macaques suggests that age may delay or impair the induction of anti-viral cellular immune responses and delay efficient return to immune homeostasis following acute infection.
References: doi: 10.1101/2021.09.08.459430
Contact Info: Emmie de Wit: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.09.08.459430v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: NIAID/NIH; The Jenner Institute at the University of Oxford
Keywords: SARS-CoV-2, multiomics profiling, young and old animals, immune response, primates
Summary of Study: Despite similar disease outcomes, multi-omics profiling in SARS-CoV-2-infected rhesus macaques suggests that age may delay or impair the induction of anti-viral cellular immune responses and delay efficient return to immune homeostasis following acute infection.
References: doi: 10.1101/2021.09.08.459430
Contact Info: Emmie de Wit: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.09.08.459430v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID, Emory University, Duke University, Moderna, Bioqual
Keywords: SARS-CoV-2, mRNA vaccine, lipid nanoparticles, immune response, pathology, primates
Summary of Study: mRNA-1273 vaccine-induced antibody responses are a mechanistic correlate of protection against SARS-CoV-2 infection in NHP.
References: PMID: 33907752 / doi: 10.1101/2021.04.20.44067
Contact Info: Robert Seder: [email protected]; Barney Graham: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.04.20.440647v2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID, Emory University, Duke University, Moderna, Bioqual
Keywords: SARS-CoV-2, mRNA vaccine, lipid nanoparticles, immune response, pathology, primates
Summary of Study: mRNA-1273 vaccine-induced antibody responses are a mechanistic correlate of protection against SARS-CoV-2 infection in NHP.
References: PMID: 33907752 / doi: 10.1101/2021.04.20.44067
Contact Info: Robert Seder: [email protected]; Barney Graham: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.04.20.440647v2
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Novavax, Inc. 21 Firstfield Road, Gaithersburg, MD, 20878
Keywords: SARS-CoV-2, subunit vaccine, pulmonary disease, primates
Summary of Study: Cynomolgus macaques immunized with NVX-CoV2373 and the saponin-based Matrix-M adjuvant induced antibody that was neutralizing and blocked binding to the human angiotensin-converting enzyme 2 (hACE2) receptor. Following intranasal and intratracheal challenge with SARS-CoV-2, immunized macaques were protected against upper and lower infection and pulmonary disease.
References: doi: https://doi.org/10.1101/2020.08.18.256578
Contact Info: Gale Smith at [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.08.18.256578v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Novavax, Inc. 21 Firstfield Road, Gaithersburg, MD, 20878
Keywords: SARS-CoV-2, subunit vaccine, pulmonary disease, primates
Summary of Study: Cynomolgus macaques immunized with NVX-CoV2373 and the saponin-based Matrix-M adjuvant induced antibody that was neutralizing and blocked binding to the human angiotensin-converting enzyme 2 (hACE2) receptor. Following intranasal and intratracheal challenge with SARS-CoV-2, immunized macaques were protected against upper and lower infection and pulmonary disease.
References: doi: https://doi.org/10.1101/2020.08.18.256578
Contact Info: Gale Smith at [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.08.18.256578v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Gritstone Bio., Inc.; Battelle Biomedical Research Center
Keywords: SARS-CoV-2, prime-boost vaccination, immune response, primates
Summary of Study: Data demonstrate that the Self-amplifying mRNA (SAM) vaccine platform can drive balanced T- and B-cell responses for optimal protective immunity at low doses, offering an additional attractive vaccine platform in the fight against current and emerging infectious pathogens.
References: doi:10.1101/2021.11.08.467773
Contact Info: Karin Jooss: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.11.08.467773v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Gritstone Bio., Inc.; Battelle Biomedical Research Center
Keywords: SARS-CoV-2, prime-boost vaccination, immune response, primates
Summary of Study: Data demonstrate that the Self-amplifying mRNA (SAM) vaccine platform can drive balanced T- and B-cell responses for optimal protective immunity at low doses, offering an additional attractive vaccine platform in the fight against current and emerging infectious pathogens.
References: doi:10.1101/2021.11.08.467773
Contact Info: Karin Jooss: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.11.08.467773v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: ReiThera Sri, Rome, Italy; The University of Nottingham
Keywords: SARS-CoV-2, gorilla adenovirus-vectored vaccine, primates
Summary of Study: Vaccine candidate, GRAd-COV2, is highly immunogenic in both mice and cynomolgus macaques, eliciting both functional antibodies which neutralize SARS-CoV-2 infection and block Spike protein binding to the ACE2 receptor, and a robust, Th1-dominated cellular response in the periphery and in the lung.
References: doi: https://doi.org/10.1101/2020.10.22.349951
Contact Info: Alessandra Vitelli: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.10.22.349951v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: ReiThera Sri, Rome, Italy; The University of Nottingham
Keywords: SARS-CoV-2, gorilla adenovirus-vectored vaccine, primates
Summary of Study: Vaccine candidate, GRAd-COV2, is highly immunogenic in both mice and cynomolgus macaques, eliciting both functional antibodies which neutralize SARS-CoV-2 infection and block Spike protein binding to the ACE2 receptor, and a robust, Th1-dominated cellular response in the periphery and in the lung.
References: doi: https://doi.org/10.1101/2020.10.22.349951
Contact Info: Alessandra Vitelli: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.10.22.349951v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: National Institute of Infectious Diseases, Tokyo, Japan
Keywords: SARS-CoV-2, T-cell populations, primates
Summary of Study: Results suggest that the peripheral T lymphocyte population is associated with pneumonia severity in cynomolgus monkeys experimentally infected with SARS-CoV-2.
References: doi: https://doi.org/10.1101/2021.01.07.425698
Contact Info: Noriyo Nagata: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.01.07.425698v1
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: National Institute of Infectious Diseases, Tokyo, Japan
Keywords: SARS-CoV-2, T-cell populations, primates
Summary of Study: Results suggest that the peripheral T lymphocyte population is associated with pneumonia severity in cynomolgus monkeys experimentally infected with SARS-CoV-2.
References: doi: https://doi.org/10.1101/2021.01.07.425698
Contact Info: Noriyo Nagata: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.01.07.425698v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Peking University Health Science Center, Beijing, China
Keywords: SARS-CoV-2, TLR4, trimeric spike protein binding, primates
Summary of Study: The spike protein of SARS-CoV-2 functions as a potent stimulus causing TLR4 activation and sepsis related abnormal responses.
References: doi: https://doi.org/10.1101/2020.12.18.423427
Contact Info: Xiangxi Wang: [email protected]/Fuping You: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.12.18.423427v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Peking University Health Science Center, Beijing, China
Keywords: SARS-CoV-2, TLR4, trimeric spike protein binding, primates
Summary of Study: The spike protein of SARS-CoV-2 functions as a potent stimulus causing TLR4 activation and sepsis related abnormal responses.
References: doi: https://doi.org/10.1101/2020.12.18.423427
Contact Info: Xiangxi Wang: [email protected]/Fuping You: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.12.18.423427v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, pigtail macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: University of Washington, UNC, Chapel Hill and others
Keywords: SARS-CoV-2, multivalent receptor-binding domain nanoparticle vaccine, immune response, variants, mice and primates
Summary of Study: Mosaic and cocktail sarbecovirus RBD-NPs elicit broad and protective Ab responses against heterologous sarbecovirus challenge, which could represent the next generation of pan-sarbecovirus vaccines.
References: PMID: 33758839 / doi: 10.1101/2021.03.15.435528
Contact Info: Neil King: [email protected]; David Veesler: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.03.15.435528v1
NHP Species: rhesus macaques, pigtail macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: University of Washington, UNC, Chapel Hill and others
Keywords: SARS-CoV-2, multivalent receptor-binding domain nanoparticle vaccine, immune response, variants, mice and primates
Summary of Study: Mosaic and cocktail sarbecovirus RBD-NPs elicit broad and protective Ab responses against heterologous sarbecovirus challenge, which could represent the next generation of pan-sarbecovirus vaccines.
References: PMID: 33758839 / doi: 10.1101/2021.03.15.435528
Contact Info: Neil King: [email protected]; David Veesler: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.03.15.435528v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: Duke University, UNC Chapel Hill, NIAID, Ragon Inst.
Keywords: SARS-CoV-2, neutralizing antibodies, cryo-electron microscopy, binding, inflammation, primates
Summary of Study: SARS-CoV-2 RBD and NTD antibodies can increase infection in vitro, but either protect or do not increase coronavirus replication in mouse and monkey models in vivo.
References: PMID: 33442694 / doi: 10.1101/2020.12.31.424729
Contact Info: Kevin Saunders: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.12.31.424729v2
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: Duke University, UNC Chapel Hill, NIAID, Ragon Inst.
Keywords: SARS-CoV-2, neutralizing antibodies, cryo-electron microscopy, binding, inflammation, primates
Summary of Study: SARS-CoV-2 RBD and NTD antibodies can increase infection in vitro, but either protect or do not increase coronavirus replication in mouse and monkey models in vivo.
References: PMID: 33442694 / doi: 10.1101/2020.12.31.424729
Contact Info: Kevin Saunders: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.12.31.424729v2
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: University of Hawaii, Bioqual, Inc., Soligenix, Inc.
Keywords: SARS-CoV-2, recombinant subunit protein vaccine, spike protein, immune response, pathology, primates
Summary of Study: A recombinant subunit protein formulated with CoVaccine HT adjuvant induces superior immunity than natural infection and reduces viral load while protecting cynomolgus macaques from COVID-19-like disease caused by late SARS-CoV-2 P.1 (Gamma) challenge.
References: doi: 10.1101/2021.09.24.461759
Contact Info: Axel Lehrer: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.09.24.461759v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: University of Hawaii, Bioqual, Inc., Soligenix, Inc.
Keywords: SARS-CoV-2, recombinant subunit protein vaccine, spike protein, immune response, pathology, primates
Summary of Study: A recombinant subunit protein formulated with CoVaccine HT adjuvant induces superior immunity than natural infection and reduces viral load while protecting cynomolgus macaques from COVID-19-like disease caused by late SARS-CoV-2 P.1 (Gamma) challenge.
References: doi: 10.1101/2021.09.24.461759
Contact Info: Axel Lehrer: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.09.24.461759v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: University of Maryland School of Medicine; Noravax
Keywords: SARS-CoV-2, receptor-binding domain subunit vaccine, immune response, mice and primates
Summary of Study: Positive results in non-human primates suggest the feasibility of utilizing a B.1.351 Spike directed variant vaccine as a booster after previous immunization with a vaccine directed toward the ancestral SARS-CoV-2 Spike protein.
References: doi: 10.1101/2021.06.08.447631
Contact Info: Matthew Frieman: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.06.08.447631v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: University of Maryland School of Medicine; Noravax
Keywords: SARS-CoV-2, receptor-binding domain subunit vaccine, immune response, mice and primates
Summary of Study: Positive results in non-human primates suggest the feasibility of utilizing a B.1.351 Spike directed variant vaccine as a booster after previous immunization with a vaccine directed toward the ancestral SARS-CoV-2 Spike protein.
References: doi: 10.1101/2021.06.08.447631
Contact Info: Matthew Frieman: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.06.08.447631v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Janssen Vaccines and Prevention, The Netherlands
Keywords: SARS-CoV-2, adenovirus-vectored vaccine, neutralization potency, aged animals, primates
Summary of Study: The Janssen Ad26.COV2.S vaccine candidate is currently the only one evaluated as a single dose vaccination regimen in Phase 3 clinical studies. This study showed that a second vaccine dose (administered 8 weeks post the first immunization) induced a significant increase in antigen-specific binding and neutralizing antibody responses in both adult and aged rhesus macaques as compared to a single dose. These data support the initiation of a two-dose Ad26.COV2.S regimen in Phase 3 clinical trial in adults and elderly.
References: doi: https://doi.org/10.1101/2020.11.17.368258
Contact Info: Roland Zahn: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.11.17.368258v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Janssen Vaccines and Prevention, The Netherlands
Keywords: SARS-CoV-2, adenovirus-vectored vaccine, neutralization potency, aged animals, primates
Summary of Study: The Janssen Ad26.COV2.S vaccine candidate is currently the only one evaluated as a single dose vaccination regimen in Phase 3 clinical studies. This study showed that a second vaccine dose (administered 8 weeks post the first immunization) induced a significant increase in antigen-specific binding and neutralizing antibody responses in both adult and aged rhesus macaques as compared to a single dose. These data support the initiation of a two-dose Ad26.COV2.S regimen in Phase 3 clinical trial in adults and elderly.
References: doi: https://doi.org/10.1101/2020.11.17.368258
Contact Info: Roland Zahn: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.11.17.368258v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: University of Texas Medical Branch, Galveston
Keywords: SARS-CoV-2, apoptosis in post-mortem lung, pathogenesis, primates
Summary of Study: Apoptosis was examined in post-mortem lung sections from COVID-19 patients and lung tissues from NHP models of SARS-CoV-2 infection. Multiple-target immunofluorescence assays and Western blotting suggest both intrinsic and extrinsic apoptotic pathways are activated during SARS-CoV-2 infection. These findings may help to delineate a novel insight into the pathogenesis of ARDS following SARS-CoV-2 infection.
References: PMID: 33398280/doi: 10.1101/2020.12.23.424254
Contact Info: Bin Gong: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.12.23.424254v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: University of Texas Medical Branch, Galveston
Keywords: SARS-CoV-2, apoptosis in post-mortem lung, pathogenesis, primates
Summary of Study: Apoptosis was examined in post-mortem lung sections from COVID-19 patients and lung tissues from NHP models of SARS-CoV-2 infection. Multiple-target immunofluorescence assays and Western blotting suggest both intrinsic and extrinsic apoptotic pathways are activated during SARS-CoV-2 infection. These findings may help to delineate a novel insight into the pathogenesis of ARDS following SARS-CoV-2 infection.
References: PMID: 33398280/doi: 10.1101/2020.12.23.424254
Contact Info: Bin Gong: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.12.23.424254v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Yerkes NPRC, NIH, Ragon Institute, and others
Keywords: SARS-CoV-2, adjuvanted soluble protein vaccines, binding and functional neutralization assays and systems serology, primates
Summary of Study: Potent serum antibody responses are induced by soluble S trimers formulated with the oil-in-water emulsion adjuvant AS03, which conferred protection in the upper and lower airways of rhesus macaques following SARS-CoV-2 challenge.
References: PMID: 33688652 / doi: 10.1101/2021.03.02.433390
Contact Info: Robert Seder: [email protected]
URL: https://pubmed.ncbi.nlm.nih.gov/33688652/
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Yerkes NPRC, NIH, Ragon Institute, and others
Keywords: SARS-CoV-2, adjuvanted soluble protein vaccines, binding and functional neutralization assays and systems serology, primates
Summary of Study: Potent serum antibody responses are induced by soluble S trimers formulated with the oil-in-water emulsion adjuvant AS03, which conferred protection in the upper and lower airways of rhesus macaques following SARS-CoV-2 challenge.
References: PMID: 33688652 / doi: 10.1101/2021.03.02.433390
Contact Info: Robert Seder: [email protected]
URL: https://pubmed.ncbi.nlm.nih.gov/33688652/
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published:
Study Type/Review: vaccine
NPRC/Institute: City of Hope National Medical Center; Bioqual
Keywords: SARS-CoV-2, vaccine efficacy, humoral and cellular immune responses, primates
Summary of Study: COH04S1, a synthetic multiantigen Modified Vaccinia Ankara-based SARS-CoV-2 vaccine that co-expresses spike and nucleocapsid antigens, demonstrated protection in animal models through different vaccination routes and dose regimens, complementing ongoing investigation of this multiantigen SARS-CoV-2 vaccine in clinical trials.
References: PMID: 34545366 / doi: 10.1101/2021.09.15.460487
Contact Info: Felix Wussow: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.09.15.460487v1
NHP Species: african green monkeys
Year Published:
Study Type/Review: vaccine
NPRC/Institute: City of Hope National Medical Center; Bioqual
Keywords: SARS-CoV-2, vaccine efficacy, humoral and cellular immune responses, primates
Summary of Study: COH04S1, a synthetic multiantigen Modified Vaccinia Ankara-based SARS-CoV-2 vaccine that co-expresses spike and nucleocapsid antigens, demonstrated protection in animal models through different vaccination routes and dose regimens, complementing ongoing investigation of this multiantigen SARS-CoV-2 vaccine in clinical trials.
References: PMID: 34545366 / doi: 10.1101/2021.09.15.460487
Contact Info: Felix Wussow: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.09.15.460487v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Inovio Pharmaceuticals; The Wistar Institute
Keywords: SARS-CoV-2, DNA vaccine candidate, immunogenicity, boost, primates
Summary of Study: Data illustrate the durability of immunity following vaccination with synthetic DNA vaccine candidates INO-4800 or INP-4802 and additional support the use of either INO-4800 or INP-4802 in prime-boost regimens.
References: doi: 10.1101/2021.10.27.466163
Contact Info: Kate Broderick: [email protected]; David Weiner: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.10.27.466163v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Inovio Pharmaceuticals; The Wistar Institute
Keywords: SARS-CoV-2, DNA vaccine candidate, immunogenicity, boost, primates
Summary of Study: Data illustrate the durability of immunity following vaccination with synthetic DNA vaccine candidates INO-4800 or INP-4802 and additional support the use of either INO-4800 or INP-4802 in prime-boost regimens.
References: doi: 10.1101/2021.10.27.466163
Contact Info: Kate Broderick: [email protected]; David Weiner: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.10.27.466163v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Clover Biopharmaceuticals, Chengdu, China
Keywords: SARS-CoV-2, Trimer-Tag technology, neutralizing antibodies, primates
Summary of Study: Rhesus macaques immunized with adjuvanted S-Trimer were protected from SARS-CoV-2 challenge compared to vehicle controls. Trimer-Tag may be an important new platform technology for scalable production and rapid development of safe and effective subunit vaccines against current and future emerging RNA viruses.
References: doi: https://doi.org/10.1101/2020.09.24.311027
Contact Info: Pen Liang: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.09.24.311027v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Clover Biopharmaceuticals, Chengdu, China
Keywords: SARS-CoV-2, Trimer-Tag technology, neutralizing antibodies, primates
Summary of Study: Rhesus macaques immunized with adjuvanted S-Trimer were protected from SARS-CoV-2 challenge compared to vehicle controls. Trimer-Tag may be an important new platform technology for scalable production and rapid development of safe and effective subunit vaccines against current and future emerging RNA viruses.
References: doi: https://doi.org/10.1101/2020.09.24.311027
Contact Info: Pen Liang: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.09.24.311027v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Nanogen Pharmaceutical Biotechnology JSC
Keywords: SARS-CoV-2, vaccine candidate, receptor-binding domain, immune response, hamsters, mice, primates
Summary of Study: Nanocovax, a vaccine candidate based on recombinant protein production of the extracellular (soluble) portion of the S protein of SARS-CoV-2, induced high levels of S protein-specific IgG, as well as neutralizing antibody in three animal models (mice, Syrian hamsters, and Macaca leonina (Northern pig-tailed macaque).
References: doi: 10.1101/2021.07.20.453162
Contact Info: Do Minh Si: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.07.20.453162v1
NHP Species: pigtail macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Nanogen Pharmaceutical Biotechnology JSC
Keywords: SARS-CoV-2, vaccine candidate, receptor-binding domain, immune response, hamsters, mice, primates
Summary of Study: Nanocovax, a vaccine candidate based on recombinant protein production of the extracellular (soluble) portion of the S protein of SARS-CoV-2, induced high levels of S protein-specific IgG, as well as neutralizing antibody in three animal models (mice, Syrian hamsters, and Macaca leonina (Northern pig-tailed macaque).
References: doi: 10.1101/2021.07.20.453162
Contact Info: Do Minh Si: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.07.20.453162v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Ragon Institute of MGH, MIT and Harvard
Keywords: SARS-CoV-2, humoral immune response, recombinant full-length spike glycoprotein (NVX-CoV2373), primates
Summary of Study: Deep profiling of the humoral immune response in a cohort of non-human primates immunized with one or two doses of 5 or 25 ug of a stabilized recombinant full-length SARS-CoV-2 spike glycoprotein with 50 ug Matrix-M adjuvant suggests that a single dose of may prevent disease, but that two doses may be essential to block further transmission of SARS-CoV-2 and emerging variants.
References: PMID: 33619473 / doi: 10.21203/rs.3.rs-200342/v1
Contact Info: Galit Alter: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899467/pdf/nihpp-rs200342v1.pdf
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Ragon Institute of MGH, MIT and Harvard
Keywords: SARS-CoV-2, humoral immune response, recombinant full-length spike glycoprotein (NVX-CoV2373), primates
Summary of Study: Deep profiling of the humoral immune response in a cohort of non-human primates immunized with one or two doses of 5 or 25 ug of a stabilized recombinant full-length SARS-CoV-2 spike glycoprotein with 50 ug Matrix-M adjuvant suggests that a single dose of may prevent disease, but that two doses may be essential to block further transmission of SARS-CoV-2 and emerging variants.
References: PMID: 33619473 / doi: 10.21203/rs.3.rs-200342/v1
Contact Info: Galit Alter: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899467/pdf/nihpp-rs200342v1.pdf
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Fred Hutchinson Cancer Research Center
Keywords: SARS-CoV-2, Remdesivir, mathematical models, primates
Summary of Study: Developed a mathematical model to explain why remdesivir has a greater antiviral effect on SARS CoV-2 in lung versus nasal passages in rhesus macaque
References: doi: https://doi.org/10.1101/2020.06.21.163550
Contact Info: Joshua Schiffer, [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.06.21.163550v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Fred Hutchinson Cancer Research Center
Keywords: SARS-CoV-2, Remdesivir, mathematical models, primates
Summary of Study: Developed a mathematical model to explain why remdesivir has a greater antiviral effect on SARS CoV-2 in lung versus nasal passages in rhesus macaque
References: doi: https://doi.org/10.1101/2020.06.21.163550
Contact Info: Joshua Schiffer, [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.06.21.163550v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Oyster Point Pharma; Trudeau Institute
Keywords: SARS-CoV-2, varenicline tartrate, in vitro and in vivo studies, virus infection, primates
Summary of Study: The nAChR agonist varenicline has the potential to interact with and inhibit SARS-CoV-2 infection and replication.
References: doi: 10.1101/2021.06.29.450426
Contact Info: Jeffrey Nau: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.06.29.450426v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Oyster Point Pharma; Trudeau Institute
Keywords: SARS-CoV-2, varenicline tartrate, in vitro and in vivo studies, virus infection, primates
Summary of Study: The nAChR agonist varenicline has the potential to interact with and inhibit SARS-CoV-2 infection and replication.
References: doi: 10.1101/2021.06.29.450426
Contact Info: Jeffrey Nau: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.06.29.450426v1