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Researchers developed an automated open-source program, FoldDesign, to create high-fidelity stable folds. Through sequence-independent replica-exchange Monte Carlo simulations and energy force field optimalization of secondary structure, FoldDesign can render novel areas of protein structure and function space that natural proteins have not reached through evolution. These completely different yet stable structures replicate natural proteins’ characteristics with closely matching buried residues and solvent-exposed areas.
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This study provides novel insights into tissue-resident memory T-cell (TRM) biology. The authors performed single-cell immune profiling to integrate clonotype, alloreactivity, and gene expression profiles of graft-repopulating recipient T cells in the intestinal mucosa after transplantation. They found that preexisting host-versus-graft (HvG)–reactive T cells were heterogenous and identified a trajectory from TRM to effector T/TRM profiles for rejection and dominant TRM profiles with tolerance in the quiescent allografts.
Supercomputing has been gaining attention for its applications across biomedical research. A type of high-performance computing...
Understanding the molecular composition and structure of proteins is essential to the mechanistic study of human health and diseases and requires the use of state-of-the-art scientific instruments.
Cryogenic electron microscopy (cryo-EM) can offer unique insights on biological molecules, enabling investigators to piece together complex structures.
Imaging plays a pivotal role in deciphering the molecular pathways of human physiology and pathophysiology. At The University of Texas Southwestern Medical Center (UT Southwestern), four instruments funded through ORIP’s S10 Shared Instrumentation Programs have contributed significantly to this role.
Located within the heart of the Delaware Biotechnology Institute Bio-Imaging Center, the Zeiss LSM 880 inverted laser scanning confocal microscope is a valuable asset for researchers at the University of Delaware (UD).
The zebrafish (Danio rerio) has been used by researchers as a model organism for human disease for decades. In recent years, however, the zebrafish has gained considerable...
A state-of-the-art flow cytometer awarded to West Virginia University (WVU) in 2013 has helped investigators make scientific advances across a remarkably wide range of disciplines. West Virginia is among the Institutional Development Award (IDeA)–eligible states, which are those that historically have had low levels of National Institutes of Health (NIH) funding.
To understand human physiology and the pathology of diseases, it is important to investigate the underlying biological processes on all spatial scales. These scales range from the patient to organs, to tissues within an organ, to individual cells within the tissue, to molecular machines within the cells, down to the atomic level. The detailed knowledge of macromolecular interactions within and in between cells in a given tissue, combined with an integrated view of an organism, significantly increases the chances for finding new cures.
