Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Research Centre for Epidemiology and Microbiology; Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences; Sechenov First Moscow State Medical University
Keywords: SARS-CoV-2, vector-based heterologous vaccine, immune response, mice, primates
Summary of Study: Intranasal Sputnik V vaccine is a novel mucosal vaccine with immunogenic and protective properties identified by immunoglobin and neutralizing antibody production, antigen-specific T-cell response, and cytokine release.
References: PMID: 36031930 / doi: 10.1080/22221751.2022.2119169
Contact Info: Amir I. Tukhvatulin: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2119169
NHP Species: marmosets
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Research Centre for Epidemiology and Microbiology; Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences; Sechenov First Moscow State Medical University
Keywords: SARS-CoV-2, vector-based heterologous vaccine, immune response, mice, primates
Summary of Study: Intranasal Sputnik V vaccine is a novel mucosal vaccine with immunogenic and protective properties identified by immunoglobin and neutralizing antibody production, antigen-specific T-cell response, and cytokine release.
References: PMID: 36031930 / doi: 10.1080/22221751.2022.2119169
Contact Info: Amir I. Tukhvatulin: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2119169
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: National Biodefense Analysis and Countermeasures Center; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health; Censeo Insight, Seattle, Washington, USA.
Keywords: SARS-CoV-2, dose–response relationships, aerosol, virus isolates, primates
Summary of Study: Provides dose response data important to inform disease transmission and hazard modeling
References: doi: 10.1089/jamp.2022.0043
Contact Info: Paul Dabisch: [email protected]
URL: https://www.liebertpub.com/doi/10.1089/jamp.2022.0043
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: National Biodefense Analysis and Countermeasures Center; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health; Censeo Insight, Seattle, Washington, USA.
Keywords: SARS-CoV-2, dose–response relationships, aerosol, virus isolates, primates
Summary of Study: Provides dose response data important to inform disease transmission and hazard modeling
References: doi: 10.1089/jamp.2022.0043
Contact Info: Paul Dabisch: [email protected]
URL: https://www.liebertpub.com/doi/10.1089/jamp.2022.0043
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Shiga University of Medical Science, Otsu, Japan; others
Keywords: SARS-CoV-2, vaccine development, attenuated vaccinia virus, immune response, proteomics, virus variants, mice, primates
Summary of Study: Vaccine protects monkeys and transgenic mice from SARS-CoV-2 and variants
References: doi: 10.3389/fmicb.2022.967019
Contact Info: Michinori Kohara: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2022.967019/full
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Shiga University of Medical Science, Otsu, Japan; others
Keywords: SARS-CoV-2, vaccine development, attenuated vaccinia virus, immune response, proteomics, virus variants, mice, primates
Summary of Study: Vaccine protects monkeys and transgenic mice from SARS-CoV-2 and variants
References: doi: 10.3389/fmicb.2022.967019
Contact Info: Michinori Kohara: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2022.967019/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: therapeutics
NPRC/Institute: Lovelace Biomedical; Gilead Sciences; Inspired - Pulmonary Solutions
Keywords: SARS-CoV-2, remdesivir, inhalation, viral load, pharmacokinetics, primates
Summary of Study: Inhaled remdesivir reduced viral load as compared with placebo in African green monkeys infected with SARS-CoV-2.
References: PMID: 34968150 / doi: 10.1126/scitranslmed.abl8282
Contact Info: Danielle Porter: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abl8282?url_ver=Z39.88-2003&rf…
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: therapeutics
NPRC/Institute: Lovelace Biomedical; Gilead Sciences; Inspired - Pulmonary Solutions
Keywords: SARS-CoV-2, remdesivir, inhalation, viral load, pharmacokinetics, primates
Summary of Study: Inhaled remdesivir reduced viral load as compared with placebo in African green monkeys infected with SARS-CoV-2.
References: PMID: 34968150 / doi: 10.1126/scitranslmed.abl8282
Contact Info: Danielle Porter: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abl8282?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: prevention
NPRC/Institute: University of Washington; Washington National Primate Research Center; Institute of Biomedical Sciences, Taipei; Fred Hutchinson Cancer Research Center
Keywords: SARS-CoV-2, helper-dependent adenovirus (HDAd5/35++), HSC gene therapy, safety, virus protection, mice, primates
Summary of Study: Pilot studies of a simple and portable in vivo hematopoietic HSC transduction approach that involves HSC mobilization from the bone marrow into the peripheral blood stream and the intravenous injection of an integrating, helper-dependent adenovirus vector system demonstrated safety and efficacy in mice and a rhesus macaque.
References: PMID: 35057635 / doi: 10.1089/hum.2021.295
Contact Info: Andre Lieber: [email protected]; Steve Roffler: [email protected]; Hans-Peter Kiem: [email protected]; Deborah Fuller: [email protected]
URL: https://www.liebertpub.com/doi/10.1089/hum.2021.295?url_ver=Z39.88-2003&rfr_id=…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: prevention
NPRC/Institute: University of Washington; Washington National Primate Research Center; Institute of Biomedical Sciences, Taipei; Fred Hutchinson Cancer Research Center
Keywords: SARS-CoV-2, helper-dependent adenovirus (HDAd5/35++), HSC gene therapy, safety, virus protection, mice, primates
Summary of Study: Pilot studies of a simple and portable in vivo hematopoietic HSC transduction approach that involves HSC mobilization from the bone marrow into the peripheral blood stream and the intravenous injection of an integrating, helper-dependent adenovirus vector system demonstrated safety and efficacy in mice and a rhesus macaque.
References: PMID: 35057635 / doi: 10.1089/hum.2021.295
Contact Info: Andre Lieber: [email protected]; Steve Roffler: [email protected]; Hans-Peter Kiem: [email protected]; Deborah Fuller: [email protected]
URL: https://www.liebertpub.com/doi/10.1089/hum.2021.295?url_ver=Z39.88-2003&rfr_id=…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Henry M. Jackson Foundation for the Advancement of Military Medicine; Washington University; NCI/NIH; Bioqual; Oak Ridge Institute of Science and Education; Columbia University Vagelos College of Physicians and Surgeons; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, nanoparticle vaccine, cellular and humoral immune responses, primates
Summary of Study: Nonhuman primates vaccinated with two doses of SpFN (a SARS-CoV-2 spike protein ferritin nanoparticle vaccine) were protected against SARS-CoV-2 challenge. SErum isolated from vaccinated animals neutralized several variants of concern, including the delta variant.
References: PMID: 39414540 / doi: 10.1126/scitranslmed.abi5735
Contact Info: M. Gordon Joyce: [email protected]; Kayvon Modjarrad: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abi5735
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Henry M. Jackson Foundation for the Advancement of Military Medicine; Washington University; NCI/NIH; Bioqual; Oak Ridge Institute of Science and Education; Columbia University Vagelos College of Physicians and Surgeons; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, nanoparticle vaccine, cellular and humoral immune responses, primates
Summary of Study: Nonhuman primates vaccinated with two doses of SpFN (a SARS-CoV-2 spike protein ferritin nanoparticle vaccine) were protected against SARS-CoV-2 challenge. SErum isolated from vaccinated animals neutralized several variants of concern, including the delta variant.
References: PMID: 39414540 / doi: 10.1126/scitranslmed.abi5735
Contact Info: M. Gordon Joyce: [email protected]; Kayvon Modjarrad: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abi5735
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: MIT; Scripps Research Institute; La Jolla Institute for Immunology; Ragon Institute of Massachusetts General Hospital, MIT, and Harvard University; University of California, San Diego; Yerkes National Primate Research Center; Emory University School of Medicine; MIT
Keywords: SARS-CoV-2, saponin/TLR agonist, vaccine adjuvant, immune response, primates
Summary of Study: Compared with a panel of tested adjuvants including other saponin-based formulations, saponin/MPLA nanoparticles (SMNP) induced superior antibody and germinal center responses after immunization with a poorly immunogenic HIV antigen in both mice and rhesus macaques, suggesting that SMNP may be a promising adjuvant in the setting of HIV, SARS-CoV-2, and other pathogens.
References: PMID: 34860581 / doi: 10.1126/sciimmunol.abf1152
Contact Info: Darrell J. Irvine: [email protected]; Shane Crotty: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.abf1152?url_ver=Z39.88-2003&rfr_…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: MIT; Scripps Research Institute; La Jolla Institute for Immunology; Ragon Institute of Massachusetts General Hospital, MIT, and Harvard University; University of California, San Diego; Yerkes National Primate Research Center; Emory University School of Medicine; MIT
Keywords: SARS-CoV-2, saponin/TLR agonist, vaccine adjuvant, immune response, primates
Summary of Study: Compared with a panel of tested adjuvants including other saponin-based formulations, saponin/MPLA nanoparticles (SMNP) induced superior antibody and germinal center responses after immunization with a poorly immunogenic HIV antigen in both mice and rhesus macaques, suggesting that SMNP may be a promising adjuvant in the setting of HIV, SARS-CoV-2, and other pathogens.
References: PMID: 34860581 / doi: 10.1126/sciimmunol.abf1152
Contact Info: Darrell J. Irvine: [email protected]; Shane Crotty: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.abf1152?url_ver=Z39.88-2003&rfr_…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Biomedical Primate Research Centre; Consejo Superior de Investigaciones Cientificas (CSIC); Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas (CIBERINFEC); Erasmus Medical Center; Instituto de Investigacion Hospital Universitario 12 de Octubre (imas12); Universidad Complutense School of Medicine, Biofabri
Keywords: SARS-CoV-2, vaccine, modified vaccinia virus Ankara vector, immune response, primates
Summary of Study: The MVA-S vaccine is safe and well tolerated in rhesus macaques, being highly immunogenic with the induction of potent levels of binding and neutralizing antibodies against several SARS-CoV-2 VOC, as well as Th1-skewed cell responses.
References: PMID: 35371043 / doi: 10.3389/fimmu.2022.845887
Contact Info: Petra Mooij: [email protected]; Juan Garcia-Arriaza: [email protected]; Gerrit Koopman: [email protected]; Mariano Esteban: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.845887/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Biomedical Primate Research Centre; Consejo Superior de Investigaciones Cientificas (CSIC); Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas (CIBERINFEC); Erasmus Medical Center; Instituto de Investigacion Hospital Universitario 12 de Octubre (imas12); Universidad Complutense School of Medicine, Biofabri
Keywords: SARS-CoV-2, vaccine, modified vaccinia virus Ankara vector, immune response, primates
Summary of Study: The MVA-S vaccine is safe and well tolerated in rhesus macaques, being highly immunogenic with the induction of potent levels of binding and neutralizing antibodies against several SARS-CoV-2 VOC, as well as Th1-skewed cell responses.
References: PMID: 35371043 / doi: 10.3389/fimmu.2022.845887
Contact Info: Petra Mooij: [email protected]; Juan Garcia-Arriaza: [email protected]; Gerrit Koopman: [email protected]; Mariano Esteban: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.845887/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Gritstone bio, Inc.; Battelle Biomedical Research Center
Keywords: SARS-CoV-2, self-amplifying mRNA vaccine, immune response, primates
Summary of Study: Report of the preclinical development of a strong self-amplifying mRNA (SAM) vaccine being evaluated in clinical trials as both a homologous prime-boost regimen at low doses and as a boost following heterologous prime
References: PMID: 35672369 PMCID: PMC9173840 DOI: 10.1038/s41467-022-31005-z
Contact Info: Karin Jooss: [email protected]
URL: https://www.nature.com/articles/s41467-022-31005-z
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Gritstone bio, Inc.; Battelle Biomedical Research Center
Keywords: SARS-CoV-2, self-amplifying mRNA vaccine, immune response, primates
Summary of Study: Report of the preclinical development of a strong self-amplifying mRNA (SAM) vaccine being evaluated in clinical trials as both a homologous prime-boost regimen at low doses and as a boost following heterologous prime
References: PMID: 35672369 PMCID: PMC9173840 DOI: 10.1038/s41467-022-31005-z
Contact Info: Karin Jooss: [email protected]
URL: https://www.nature.com/articles/s41467-022-31005-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Center for Genetic Engineering and Biotechnology; Civilian Defense Scienti?c Research Center, Carretera de Jamaica y Autopista Nacional; Biotechnology and Pharmaceutical Industries Group, BioCubaFarma, Ave; Latin American School of Medicine
Keywords: SARS-CoV-2, vaccine, yeast, manufacturing, mice, primates
Summary of Study: The COVID-19 receptor-binding domain produced in yeast cells can be modified by adding amino acids in order to create a possible vaccine candidate due to its ability to stimulate anti-inflammatory cells and inhibit binding to ACE2.
References: PMID: 35953030 / doi: 10.1016/j.nbt.2022.08.002
Contact Info: Gerardo Guillén-Nieto: Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Ave. 31 E/ 158 y 190, La Habana 10600, Cuba
URL: https://www.sciencedirect.com/science/article/pii/S1871678422000462?via%3Dihub
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Center for Genetic Engineering and Biotechnology; Civilian Defense Scienti?c Research Center, Carretera de Jamaica y Autopista Nacional; Biotechnology and Pharmaceutical Industries Group, BioCubaFarma, Ave; Latin American School of Medicine
Keywords: SARS-CoV-2, vaccine, yeast, manufacturing, mice, primates
Summary of Study: The COVID-19 receptor-binding domain produced in yeast cells can be modified by adding amino acids in order to create a possible vaccine candidate due to its ability to stimulate anti-inflammatory cells and inhibit binding to ACE2.
References: PMID: 35953030 / doi: 10.1016/j.nbt.2022.08.002
Contact Info: Gerardo Guillén-Nieto: Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Ave. 31 E/ 158 y 190, La Habana 10600, Cuba
URL: https://www.sciencedirect.com/science/article/pii/S1871678422000462?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIBSC Division of Infectious Disease Diagnostics, Division of Virology, Division of Analytical and Biological Sciences, other, Hertfordshire, UK
Keywords: SARS-CoV-2, virology, molecular and pathological outcomes, several animal species, primates
Summary of Study: Viral outcomes in multiple species
References: doi: 10.1038/s41598-022-23339-x
Contact Info: Neil Berry: [email protected]
URL: https://www.nature.com/articles/s41598-022-23339-x
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIBSC Division of Infectious Disease Diagnostics, Division of Virology, Division of Analytical and Biological Sciences, other, Hertfordshire, UK
Keywords: SARS-CoV-2, virology, molecular and pathological outcomes, several animal species, primates
Summary of Study: Viral outcomes in multiple species
References: doi: 10.1038/s41598-022-23339-x
Contact Info: Neil Berry: [email protected]
URL: https://www.nature.com/articles/s41598-022-23339-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Fudan University; The University of Hong Kong; Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park; Graduate School of Peking Union Medical College; National Institute for Food and Drug Control, Beijing, China; Fulgent Pharma LLC
Keywords: SARS-CoV-2, pan-sarbecovirus vaccine, immune response, virus variants, primates
Summary of Study: A pan-sarbecovirus vaccine consisting of human IgG Fc fragment-conjugated RBC of the original SARS-CoV-2 WA1 strain as the immunogen and a novel small-molecule non-nucleotide STING agonist as the adjuvant could be used to prevent infection by the current SARS-CoV-2 variants, including Omicron, and future emerging sarbecoviruses.
References: PMID: 35210607 / doi: 10. 1038/s41422-022-00631-z
Contact Info: Youchun Wang: [email protected]
URL: https://www.nature.com/articles/s41422-022-00631-z
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Fudan University; The University of Hong Kong; Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park; Graduate School of Peking Union Medical College; National Institute for Food and Drug Control, Beijing, China; Fulgent Pharma LLC
Keywords: SARS-CoV-2, pan-sarbecovirus vaccine, immune response, virus variants, primates
Summary of Study: A pan-sarbecovirus vaccine consisting of human IgG Fc fragment-conjugated RBC of the original SARS-CoV-2 WA1 strain as the immunogen and a novel small-molecule non-nucleotide STING agonist as the adjuvant could be used to prevent infection by the current SARS-CoV-2 variants, including Omicron, and future emerging sarbecoviruses.
References: PMID: 35210607 / doi: 10. 1038/s41422-022-00631-z
Contact Info: Youchun Wang: [email protected]
URL: https://www.nature.com/articles/s41422-022-00631-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tsinghua University; Chongqing Medical University; Boston University School of Medicine; Chinese Academy of Sciences; Shenzhen Bay Laboratory; Peking University Shenshen Graduate School; Fudan University
Keywords: SARS-CoV-2, pathogenesis, neutralization antibodies, primates
Summary of Study: Kappa, Delta, or B.1.618 spike uses human angiotensin-converting enzyme 2 (ACE2) with no or slightly increased efficiency, while it gains a significantly increased binding affinity with mouse, marmoset, and koala ACE2 orthologs, which exhibit limited binding with wild-type (WT) spike. Collectively, this study revealed that enhanced human and mouse ASE receptor engagement, increased spike cleavage, and reduced sensitivity to neutralization antibodies of Kapa, Delta and B.1.618 may contribute to the rapid spread of these variants.
References: PMID: 35266815 / doi: 10.1128/mbio.00099-22
Contact Info: Qiang Ding: [email protected]
URL: https://journals.asm.org/doi/full/10.1128/mbio.00099-22?rfr_dat=cr_pub++0pubmed…
NHP Species: marmosets
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tsinghua University; Chongqing Medical University; Boston University School of Medicine; Chinese Academy of Sciences; Shenzhen Bay Laboratory; Peking University Shenshen Graduate School; Fudan University
Keywords: SARS-CoV-2, pathogenesis, neutralization antibodies, primates
Summary of Study: Kappa, Delta, or B.1.618 spike uses human angiotensin-converting enzyme 2 (ACE2) with no or slightly increased efficiency, while it gains a significantly increased binding affinity with mouse, marmoset, and koala ACE2 orthologs, which exhibit limited binding with wild-type (WT) spike. Collectively, this study revealed that enhanced human and mouse ASE receptor engagement, increased spike cleavage, and reduced sensitivity to neutralization antibodies of Kapa, Delta and B.1.618 may contribute to the rapid spread of these variants.
References: PMID: 35266815 / doi: 10.1128/mbio.00099-22
Contact Info: Qiang Ding: [email protected]
URL: https://journals.asm.org/doi/full/10.1128/mbio.00099-22?rfr_dat=cr_pub++0pubmed…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane School of Medicine
Keywords: SARS-CoV-2, monoclonal antibody prophylaxis, virus reproduction, primates
Summary of Study: High viral loads were observed in the intestinal mucosa of a rhesus macaque post challenge with SARS-CoV-2 after prophylactic administration of combination anti-spike antibody therapy. Intrahost evolution of virus was seen, with sequences changing in accordance with enhanced replication capacity, as well as site-specific differences potentially indicating preferential replication.
References: PMID: 35429402 / doi: 10.1093/infdis/jiac134
Contact Info: Chad Roy: [email protected]
URL: https://academic.oup.com/jid/article/226/9/1588/6569365?login=false
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane School of Medicine
Keywords: SARS-CoV-2, monoclonal antibody prophylaxis, virus reproduction, primates
Summary of Study: High viral loads were observed in the intestinal mucosa of a rhesus macaque post challenge with SARS-CoV-2 after prophylactic administration of combination anti-spike antibody therapy. Intrahost evolution of virus was seen, with sequences changing in accordance with enhanced replication capacity, as well as site-specific differences potentially indicating preferential replication.
References: PMID: 35429402 / doi: 10.1093/infdis/jiac134
Contact Info: Chad Roy: [email protected]
URL: https://academic.oup.com/jid/article/226/9/1588/6569365?login=false
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: USAMRIID
Keywords: SARS-CoV-2, routes of exposure, pathology, primates
Summary of Study: Cynomolgus macaques may be the better model for SARS-CoV-2 than RM, as these animals had the most severe and consistent disease presentation.
References: PMID: 35632755 / doi: 10.3390/v14051013
Contact Info: Jay Hooper: [email protected]; Jeffrey Koehler: [email protected]; Charles Shoemaker: [email protected]; Tamara Clements: [email protected]; Alexandra Jay: [email protected]
URL: https://www.mdpi.com/1999-4915/14/5/1013
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: USAMRIID
Keywords: SARS-CoV-2, routes of exposure, pathology, primates
Summary of Study: Cynomolgus macaques may be the better model for SARS-CoV-2 than RM, as these animals had the most severe and consistent disease presentation.
References: PMID: 35632755 / doi: 10.3390/v14051013
Contact Info: Jay Hooper: [email protected]; Jeffrey Koehler: [email protected]; Charles Shoemaker: [email protected]; Tamara Clements: [email protected]; Alexandra Jay: [email protected]
URL: https://www.mdpi.com/1999-4915/14/5/1013
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Zalgen Labs, LLC; Duke University Medical Center, Duke Human Vaccine Institute;
Keywords: SARS-CoV-2, viral kinetics, immune response, primates
Summary of Study: Pulmonary outcome of COVID-19 is not influenced by route of infection even though clinical onset shows differences.
References: PMID: 35789343 / doi: 10.1371/journal.ppat.1010618
Contact Info: Chad Roy: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010618
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Zalgen Labs, LLC; Duke University Medical Center, Duke Human Vaccine Institute;
Keywords: SARS-CoV-2, viral kinetics, immune response, primates
Summary of Study: Pulmonary outcome of COVID-19 is not influenced by route of infection even though clinical onset shows differences.
References: PMID: 35789343 / doi: 10.1371/journal.ppat.1010618
Contact Info: Chad Roy: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010618
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Stanford University; University of Washington; Emory National Primate Research Center, and Emory University School of Medicine; Tulane National Primate Research Center; University of Louisiana at Lafayette; University of Maryland School of Medicine; University of California, San Diego; La Jolla Institute for Immunology; GSK; Bill and Melinda Gates Foundation; Tulane University School of Medicine;
Keywords: SARS-CoV-2, adjuvanted subunit vaccine, immune response, primates
Summary of Study: An adjuvanted subunit vaccine results in significant and durable memory T- and B-cell responses to Beta and Omicron variants and was found to suppress viral load and protect lungs after Omicron infection.
References: PMID: 35976993 / doi: 10.1126/scitranslmed.abq4130
Contact Info: Bali Pulendran: [email protected]
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abq4130?rfr_dat=cr_pub++0…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Stanford University; University of Washington; Emory National Primate Research Center, and Emory University School of Medicine; Tulane National Primate Research Center; University of Louisiana at Lafayette; University of Maryland School of Medicine; University of California, San Diego; La Jolla Institute for Immunology; GSK; Bill and Melinda Gates Foundation; Tulane University School of Medicine;
Keywords: SARS-CoV-2, adjuvanted subunit vaccine, immune response, primates
Summary of Study: An adjuvanted subunit vaccine results in significant and durable memory T- and B-cell responses to Beta and Omicron variants and was found to suppress viral load and protect lungs after Omicron infection.
References: PMID: 35976993 / doi: 10.1126/scitranslmed.abq4130
Contact Info: Bali Pulendran: [email protected]
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abq4130?rfr_dat=cr_pub++0…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: California National Primate Research Center; University of California, Davis
Keywords: SARS-CoV-2, surveillance, diagnostics, multi-antigen assays , RT-PCR, primates
Summary of Study: Colony management practices including restricted access, PPE, personnel vaccination and testing requirements have been adequate to prevent the spread of COVID-19 within the CNPRC NHP colony along with developing multi-antigen assays to survey the population.
References: PMID: 35794847 / doi: 10.1111/jmp.12604
Contact Info: JoAnn Yee: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1111/jmp.12604
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: California National Primate Research Center; University of California, Davis
Keywords: SARS-CoV-2, surveillance, diagnostics, multi-antigen assays , RT-PCR, primates
Summary of Study: Colony management practices including restricted access, PPE, personnel vaccination and testing requirements have been adequate to prevent the spread of COVID-19 within the CNPRC NHP colony along with developing multi-antigen assays to survey the population.
References: PMID: 35794847 / doi: 10.1111/jmp.12604
Contact Info: JoAnn Yee: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1111/jmp.12604
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; CureVac AG, Tübingen, Germany
Keywords: SARS-CoV-2, unmodified mRNA vaccine, CVnCoV, immune response, primates
Summary of Study: A third dose of the unmodified COVID-19 mRNA vaccine CVnCoV enhances quality and quantity of immune responses.
References: doi: 10.1016/j.omtm.2022.10.001
Contact Info: Karin Loré: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2329050122001437?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; CureVac AG, Tübingen, Germany
Keywords: SARS-CoV-2, unmodified mRNA vaccine, CVnCoV, immune response, primates
Summary of Study: A third dose of the unmodified COVID-19 mRNA vaccine CVnCoV enhances quality and quantity of immune responses.
References: doi: 10.1016/j.omtm.2022.10.001
Contact Info: Karin Loré: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2329050122001437?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chin Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, China
Keywords: SARS-CoV-2, review, traditional Chinese medicine, mice, hamsters, primates
Summary of Study: Model exploration for discovering COVID-19 targeted traditional Chinese medicine
References: doi: 10.1016/j.heliyon.2022.e12333
Contact Info: Fengmei Lian: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2405844022036210?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chin Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, China
Keywords: SARS-CoV-2, review, traditional Chinese medicine, mice, hamsters, primates
Summary of Study: Model exploration for discovering COVID-19 targeted traditional Chinese medicine
References: doi: 10.1016/j.heliyon.2022.e12333
Contact Info: Fengmei Lian: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2405844022036210?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Washington University; National Cancer Institute/NIH; Bioqual; Oak Ridge Institute of Science & Education; Columbia University Vagelos College of Physicians and Surgeons; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, spike protein ferritin nanoparticle (SpFN) vaccine, immune response, primates
Summary of Study: NHPs vaccinated with two doses of SpFN plus adjuvant separated by 28 days developed potent SARS-CoV-2-specific B and T cell responses, which conferred protection against SARS-CoV-2 challenge.
References: PMID: 34914540 / doi: 10.1126/scitranslmed.abi5735
Contact Info: Kayvon Modjarrad: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abi5735?url_ver=Z39.88-2003&rf…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Washington University; National Cancer Institute/NIH; Bioqual; Oak Ridge Institute of Science & Education; Columbia University Vagelos College of Physicians and Surgeons; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, spike protein ferritin nanoparticle (SpFN) vaccine, immune response, primates
Summary of Study: NHPs vaccinated with two doses of SpFN plus adjuvant separated by 28 days developed potent SARS-CoV-2-specific B and T cell responses, which conferred protection against SARS-CoV-2 challenge.
References: PMID: 34914540 / doi: 10.1126/scitranslmed.abi5735
Contact Info: Kayvon Modjarrad: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abi5735?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Zhongshan School of Medicine; Qianyang Biomedical Research Institute; Guangdong Provincial Center for Disease Control and Prevention
Keywords: SARS-CoV-2, bivalent vaccine, D614G/B.1.351, vaccine dosage, mice, primates
Summary of Study: With a prime-boost or single-dose strategy a bivalent D614G/B.1.351 RBD nanoparticle vaccine elicited robust nAbs and full protection against infection with the authentic D614 or B.1.351 strains in human ACE2 transgene mice. Furthermore, 8 months after inoculation with the D614G-specific vaccine, a new boost with this bivalent vaccine potently elicited cross-nAbs for SARS-CoV-2 variants in rhesus macaques.
References: PMID: 34990583 / doi: 10.1016/j.celrep.2021.110256
Contact Info: Yiwen Zhang: [email protected]; Hui Zhang: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S221112472101768X?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Zhongshan School of Medicine; Qianyang Biomedical Research Institute; Guangdong Provincial Center for Disease Control and Prevention
Keywords: SARS-CoV-2, bivalent vaccine, D614G/B.1.351, vaccine dosage, mice, primates
Summary of Study: With a prime-boost or single-dose strategy a bivalent D614G/B.1.351 RBD nanoparticle vaccine elicited robust nAbs and full protection against infection with the authentic D614 or B.1.351 strains in human ACE2 transgene mice. Furthermore, 8 months after inoculation with the D614G-specific vaccine, a new boost with this bivalent vaccine potently elicited cross-nAbs for SARS-CoV-2 variants in rhesus macaques.
References: PMID: 34990583 / doi: 10.1016/j.celrep.2021.110256
Contact Info: Yiwen Zhang: [email protected]; Hui Zhang: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S221112472101768X?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Institute de Biologie Structurale; Universite Paris-Saclay, Inserm, CEA; Amsterdam University Medical Centers; Institute Pasteur, Universite de Paris; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, vaccine candidate, synthetic spike (S) glycoprotein-coated lipid vesicles, immune response, primates
Summary of Study: Immunization of cynomolgus macaques with S coated onto lipid vesicles (S-LVs) induces high antibody titers with potent neutralizing activity against the vaccine strain, Alpha, Beta, and Gamma variants as well as T helper (Th)1 CD4+-biased T cell responses.
References: PMID: 35233549 / doi: 10.1016/j.xcrm.2022.100528
Contact Info: Winfried Weissenhorn: [email protected]; Roger Le Grand: [email protected]
URL: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00028-3?_retu…
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Institute de Biologie Structurale; Universite Paris-Saclay, Inserm, CEA; Amsterdam University Medical Centers; Institute Pasteur, Universite de Paris; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, vaccine candidate, synthetic spike (S) glycoprotein-coated lipid vesicles, immune response, primates
Summary of Study: Immunization of cynomolgus macaques with S coated onto lipid vesicles (S-LVs) induces high antibody titers with potent neutralizing activity against the vaccine strain, Alpha, Beta, and Gamma variants as well as T helper (Th)1 CD4+-biased T cell responses.
References: PMID: 35233549 / doi: 10.1016/j.xcrm.2022.100528
Contact Info: Winfried Weissenhorn: [email protected]; Roger Le Grand: [email protected]
URL: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00028-3?_retu…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; China National Center for Bioinformation; Capital Medical University; Chinese Academy of Medical Sciences and Peking Union Medical College; Huazhong University of Science & Technology
Keywords: SARS-CoV-2, transcriptomic profiling, virus replication, primates
Summary of Study: This study provides the transcriptome profiling of various tissues from the living primate host post SARS-CoV-2 infection. It illustrates that wide-spread transcriptomic changes involving diverse functions exist in multi-organs; an elevated immune response in cerebral cortex was the prominent feature at the early stage of SARS-CoV-2 infection.
References: PMID: 35377064 / doi: 10.1007/s13238-022-00915-5
Contact Info: Ying Yang: [email protected]; Yun-Gui Yang: [email protected]; Chuan Qin: [email protected]; Wei-Min Tong: [email protected]
URL: https://link.springer.com/article/10.1007/s13238-022-00915-5
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; China National Center for Bioinformation; Capital Medical University; Chinese Academy of Medical Sciences and Peking Union Medical College; Huazhong University of Science & Technology
Keywords: SARS-CoV-2, transcriptomic profiling, virus replication, primates
Summary of Study: This study provides the transcriptome profiling of various tissues from the living primate host post SARS-CoV-2 infection. It illustrates that wide-spread transcriptomic changes involving diverse functions exist in multi-organs; an elevated immune response in cerebral cortex was the prominent feature at the early stage of SARS-CoV-2 infection.
References: PMID: 35377064 / doi: 10.1007/s13238-022-00915-5
Contact Info: Ying Yang: [email protected]; Yun-Gui Yang: [email protected]; Chuan Qin: [email protected]; Wei-Min Tong: [email protected]
URL: https://link.springer.com/article/10.1007/s13238-022-00915-5
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Sanofi R&D; Universite de Strasbourg; Equipe 3Bio
Keywords: SARS-CoV-2, mRNA vaccine, lipid nanoparticles, stability, mice, primates
Summary of Study: The thermostability of mRNA/LNP is improved by a novel imidazole modified lipid, DOG-IM4, in combination with standard helper lipids.
References: PMID: 35576809 / doi: 10.1016/j.biomaterials.2022.121570
Contact Info: Jean Haensler: [email protected];
URL: https://www.sciencedirect.com/science/article/pii/S0142961222002101?via%3Dihub
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Sanofi R&D; Universite de Strasbourg; Equipe 3Bio
Keywords: SARS-CoV-2, mRNA vaccine, lipid nanoparticles, stability, mice, primates
Summary of Study: The thermostability of mRNA/LNP is improved by a novel imidazole modified lipid, DOG-IM4, in combination with standard helper lipids.
References: PMID: 35576809 / doi: 10.1016/j.biomaterials.2022.121570
Contact Info: Jean Haensler: [email protected];
URL: https://www.sciencedirect.com/science/article/pii/S0142961222002101?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: Departments of Biochemistry and Pathology & Laboratory Medicine, Bhopal, India
Keywords: SARS-CoV-2, review, animal models, infection, pathology, primates
Summary of Study: Review of the immunological and clinical manifestations observed in various natural and genetically-modified animal models of numerous COVID-19 studies. The authors also summarize up-to-date laboratory findings on available and significant COVID-19 animal models, and put forth their perspective for the objective dependent usage of animal models.
References: PMID: 35757923 DOI: 10.1080/08830185.2022.2089666
Contact Info: Ashok Kumar: [email protected]
URL: https://www.tandfonline.com/doi/abs/10.1080/08830185.2022.2089666?journalCode=i…
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: Departments of Biochemistry and Pathology & Laboratory Medicine, Bhopal, India
Keywords: SARS-CoV-2, review, animal models, infection, pathology, primates
Summary of Study: Review of the immunological and clinical manifestations observed in various natural and genetically-modified animal models of numerous COVID-19 studies. The authors also summarize up-to-date laboratory findings on available and significant COVID-19 animal models, and put forth their perspective for the objective dependent usage of animal models.
References: PMID: 35757923 DOI: 10.1080/08830185.2022.2089666
Contact Info: Ashok Kumar: [email protected]
URL: https://www.tandfonline.com/doi/abs/10.1080/08830185.2022.2089666?journalCode=i…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Ragon Institute of MGH, MIT, and Harvard; University of Massachusetts; Bioqual
Keywords: SARS-CoV-2, adenovirus vector–based vaccine Ad26.COV2.S, immune response, primates
Summary of Study: Cytotoxic T-cells that are vaccine induced contribute to virus control, and when depleted, higher viral loads are seen in the respiratory tract.
References: PMID: 35943359 / doi: 10.1126/sciimmunol.abq7647
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/full/10.1126/sciimmunol.abq7647?rfr_dat=cr_pub++0pu…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Ragon Institute of MGH, MIT, and Harvard; University of Massachusetts; Bioqual
Keywords: SARS-CoV-2, adenovirus vector–based vaccine Ad26.COV2.S, immune response, primates
Summary of Study: Cytotoxic T-cells that are vaccine induced contribute to virus control, and when depleted, higher viral loads are seen in the respiratory tract.
References: PMID: 35943359 / doi: 10.1126/sciimmunol.abq7647
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/full/10.1126/sciimmunol.abq7647?rfr_dat=cr_pub++0pu…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID RNA Viruses Section, Laboratory of Infectious Diseases, numerous others
Keywords: SARS-CoV-2, pediatric vaccine, live-attenuated parainfluenza-virus-vectored vaccine, immunogenicity, primates
Summary of Study: Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine is protective in monkeys
References: doi: 10.1016/j.cell.2022.11.006
Contact Info: Ursula Buchholz: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0092867422014180?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID RNA Viruses Section, Laboratory of Infectious Diseases, numerous others
Keywords: SARS-CoV-2, pediatric vaccine, live-attenuated parainfluenza-virus-vectored vaccine, immunogenicity, primates
Summary of Study: Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine is protective in monkeys
References: doi: 10.1016/j.cell.2022.11.006
Contact Info: Ursula Buchholz: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0092867422014180?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center, Texas Biomedical Research Institute; Washington University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, longitudinal scRNAseq, bronchoalveolar lavage, immune response, primates
Summary of Study: Results unequivocally show that in protected, immunocompetent hosts, SARS-CoV-2 infection is characterized by an acute inflammatory response leading to a myeloid cell influx into the lung compartment. Induction of a robust IFN response in macrophages strongly correlates with viremia and subsequent clearance of SARS-CoV-2 from the airways of macaques.
References: PMID: 35115549 / doi: 10.1038/s41467-022-28315-7
Contact Info: Maxim Artyomov: [email protected]
URL: https://www.nature.com/articles/s41467-022-28315-7
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center, Texas Biomedical Research Institute; Washington University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, longitudinal scRNAseq, bronchoalveolar lavage, immune response, primates
Summary of Study: Results unequivocally show that in protected, immunocompetent hosts, SARS-CoV-2 infection is characterized by an acute inflammatory response leading to a myeloid cell influx into the lung compartment. Induction of a robust IFN response in macrophages strongly correlates with viremia and subsequent clearance of SARS-CoV-2 from the airways of macaques.
References: PMID: 35115549 / doi: 10.1038/s41467-022-28315-7
Contact Info: Maxim Artyomov: [email protected]
URL: https://www.nature.com/articles/s41467-022-28315-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Sun Yat-sen University; Guangdong Academy of Medical Sciences; Qianyang Biomedical Research Institute; Guangdong Provincial Center for Disease Control and Prevention
Keywords: SARS-CoV-2, Receptor Binding Domain (RBD)-Conjugated Nanoparticle Vaccine, virus variants, hACE2 mice, primates
Summary of Study: RBD-based monovalent or multivalent nanoparticle vaccines provide a promising second-generation vaccine strategy for SARS-CoV-2 variants.
References: PMID: 35142444 / doi: 10.1002/advs.202105378
Contact Info: Ting Pan: [email protected]; Hui Zhang: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008796/
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Sun Yat-sen University; Guangdong Academy of Medical Sciences; Qianyang Biomedical Research Institute; Guangdong Provincial Center for Disease Control and Prevention
Keywords: SARS-CoV-2, Receptor Binding Domain (RBD)-Conjugated Nanoparticle Vaccine, virus variants, hACE2 mice, primates
Summary of Study: RBD-based monovalent or multivalent nanoparticle vaccines provide a promising second-generation vaccine strategy for SARS-CoV-2 variants.
References: PMID: 35142444 / doi: 10.1002/advs.202105378
Contact Info: Ting Pan: [email protected]; Hui Zhang: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008796/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Universite Paris-Saclay, Inserm, CEA; University of Amsterdam; Grousbeck Gene Therapy Center; Harvard Medical School; The Broad Institute of Harvard and MIT; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, computed X-ray tomography and [18F]-FDG positron emission tomography, pathology, primates
Summary of Study: CT, combined with [18F]-FDG PET imaging, to study SARS-CoV-2 infected NHPs, can produce strong and transposable readouts to monitor COVID-19 disease as well as the efficacy of future treatments and vaccine candidates.
References: PMID: 35313622 / doi: 10.1016/j.isci.2022.104101
Contact Info: Thibaut Naninck: [email protected]
URL: https://www.cell.com/iscience/fulltext/S2589-0042(22)00371-6?_returnURL=https%3…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Universite Paris-Saclay, Inserm, CEA; University of Amsterdam; Grousbeck Gene Therapy Center; Harvard Medical School; The Broad Institute of Harvard and MIT; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, computed X-ray tomography and [18F]-FDG positron emission tomography, pathology, primates
Summary of Study: CT, combined with [18F]-FDG PET imaging, to study SARS-CoV-2 infected NHPs, can produce strong and transposable readouts to monitor COVID-19 disease as well as the efficacy of future treatments and vaccine candidates.
References: PMID: 35313622 / doi: 10.1016/j.isci.2022.104101
Contact Info: Thibaut Naninck: [email protected]
URL: https://www.cell.com/iscience/fulltext/S2589-0042(22)00371-6?_returnURL=https%3…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of California, Davis, School of Medicine
Keywords: SARS-CoV-2, pre-existing HIV infection, gene expression, metabolomics, primates
Summary of Study: SIV infection resulted in sustained or increased ACE2 expression in an inflamed and immune-impaired gut mucosal microenvironment.
References: PMID: 35495669 / doi: 10.3389/fmicb.2022.879152
Contact Info: Satya Dandekar: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2022.879152/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of California, Davis, School of Medicine
Keywords: SARS-CoV-2, pre-existing HIV infection, gene expression, metabolomics, primates
Summary of Study: SIV infection resulted in sustained or increased ACE2 expression in an inflamed and immune-impaired gut mucosal microenvironment.
References: PMID: 35495669 / doi: 10.3389/fmicb.2022.879152
Contact Info: Satya Dandekar: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2022.879152/full
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: The Broad Institute of Harvard and MIT; Harvard University; Universite Paris-Saclay, Inserm, CEA; Genethon INTEGRARE UMR; Rega Institute; University of Siena; University of Pennsylvania
Keywords: SARS-CoV-2, AAV-based vaccine, virus variants, immune response, mice, primates
Summary of Study: AAV-based vaccines for COVID-19 can be effective from a single, low dose and lead to durable humoral and strong T cell immunogenicity.
References: PMID: 35546782 / doi: 10.1016/j.ymthe.2022.05.007
Contact Info: Luk Vandenberghe: [email protected]
URL: https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-…
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: The Broad Institute of Harvard and MIT; Harvard University; Universite Paris-Saclay, Inserm, CEA; Genethon INTEGRARE UMR; Rega Institute; University of Siena; University of Pennsylvania
Keywords: SARS-CoV-2, AAV-based vaccine, virus variants, immune response, mice, primates
Summary of Study: AAV-based vaccines for COVID-19 can be effective from a single, low dose and lead to durable humoral and strong T cell immunogenicity.
References: PMID: 35546782 / doi: 10.1016/j.ymthe.2022.05.007
Contact Info: Luk Vandenberghe: [email protected]
URL: https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: GigaGen, Inc.; Alira Health, Inc.; Grifols S.A.; Vitalant Research Institute; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, drugs, GMP, clinical manufacturing, therapy, mice, primates
Summary of Study: A novel class of drugs, recombinant hyperimmune globulins are a safe and protective possible treatment to COVID-19 that could be made through large-scale production.
References: PMID: 35890050 / doi: 10.3390/pathogens11070806
Contact Info: Adam Adler: [email protected]
URL: https://www.mdpi.com/2076-0817/11/7/806
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: GigaGen, Inc.; Alira Health, Inc.; Grifols S.A.; Vitalant Research Institute; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, drugs, GMP, clinical manufacturing, therapy, mice, primates
Summary of Study: A novel class of drugs, recombinant hyperimmune globulins are a safe and protective possible treatment to COVID-19 that could be made through large-scale production.
References: PMID: 35890050 / doi: 10.3390/pathogens11070806
Contact Info: Adam Adler: [email protected]
URL: https://www.mdpi.com/2076-0817/11/7/806
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Research Institute for Biological Safety Problems, Kazakhstan
Keywords: SARS-CoV-2, inactivated vaccine, safety, immune response, several animal species, primates
Summary of Study: The first COVID-19 inactivated vaccine developed in Kazakhstan did not result in any adverse effect or change in condition of the animals' health, has high immunogenic potential, and is safe to move to clinical research.
References: PMID: 35960911 / doi: 10.1080/21645515.2022.2087412
Contact Info: Zhandos Abay: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/21645515.2022.2087412
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Research Institute for Biological Safety Problems, Kazakhstan
Keywords: SARS-CoV-2, inactivated vaccine, safety, immune response, several animal species, primates
Summary of Study: The first COVID-19 inactivated vaccine developed in Kazakhstan did not result in any adverse effect or change in condition of the animals' health, has high immunogenic potential, and is safe to move to clinical research.
References: PMID: 35960911 / doi: 10.1080/21645515.2022.2087412
Contact Info: Zhandos Abay: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/21645515.2022.2087412
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; AstraZeneca; Vanderbilt University Medical Center; Ragon Institute of MGH, MIT, and Harvard, Cambridge
Keywords: SARS-CoV-2, vaccine, bivalent monoclonal antibody, immune response, primates
Summary of Study: Using human monoclonal antibodies that target the spike glycoprotein can be administered along with viral vector-based SARS-CoV-2 vaccines without losing any effectiveness of either product.
References: PMID: 35857623 / doi: 10.1126/scitranslmed.abo6160
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abo6160?rfr_dat=cr_pub++0…
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; AstraZeneca; Vanderbilt University Medical Center; Ragon Institute of MGH, MIT, and Harvard, Cambridge
Keywords: SARS-CoV-2, vaccine, bivalent monoclonal antibody, immune response, primates
Summary of Study: Using human monoclonal antibodies that target the spike glycoprotein can be administered along with viral vector-based SARS-CoV-2 vaccines without losing any effectiveness of either product.
References: PMID: 35857623 / doi: 10.1126/scitranslmed.abo6160
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abo6160?rfr_dat=cr_pub++0…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: hhc Data Creation Center, Tsukuba Research Laboratories, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan; Drug Discovery Platform, KAN Research Institute, Inc., 6-8-2 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan; Medicine Development Center, Tsukuba Research Laboratories, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan; Department of Immunology and Parasitology, Graduate School of Medicine, Tokushima University, Tokushima 770-8503, Japan.
Keywords: SARS-CoV-2, lipid nanoparticles, encapsulated mRNA, immunogenicity, mice, primates
Summary of Study:
References: doi: 10.1016/j.omtn.2022.09.017
Contact Info: Yuta Suzuki: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2162253122002608?via%3Dihub
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: hhc Data Creation Center, Tsukuba Research Laboratories, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan; Drug Discovery Platform, KAN Research Institute, Inc., 6-8-2 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan; Medicine Development Center, Tsukuba Research Laboratories, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan; Department of Immunology and Parasitology, Graduate School of Medicine, Tokushima University, Tokushima 770-8503, Japan.
Keywords: SARS-CoV-2, lipid nanoparticles, encapsulated mRNA, immunogenicity, mice, primates
Summary of Study:
References: doi: 10.1016/j.omtn.2022.09.017
Contact Info: Yuta Suzuki: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2162253122002608?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Duke University School of Medicine, Durham, NC; California National Primate Research Center; others.
Keywords: SARS-CoV-2, age-dependent responses, immune response, pathology, primates
Summary of Study: Age-dependent responses to SARS-CoV-2 in dam/infant pairs
References: doi: 10.4049/immunohorizons.2200075
Contact Info: Maria Blasi: [email protected]
URL: https://journals.aai.org/immunohorizons/article/6/12/851/237621/Dam-Infant-Rhes…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Duke University School of Medicine, Durham, NC; California National Primate Research Center; others.
Keywords: SARS-CoV-2, age-dependent responses, immune response, pathology, primates
Summary of Study: Age-dependent responses to SARS-CoV-2 in dam/infant pairs
References: doi: 10.4049/immunohorizons.2200075
Contact Info: Maria Blasi: [email protected]
URL: https://journals.aai.org/immunohorizons/article/6/12/851/237621/Dam-Infant-Rhes…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre/The Netherlands; NIAID; University Paris-Saclay, Inserm; Tulane National Primate Research Center; University of Pittsburgh School of Medicine; University of Pittsburgh Center for Vaccine Research; Texas Biomedical Research Institute; Frederick National Laboratory for Cancer Research
Keywords: SARS-CoV-2, advanced medical imaging, pathogenesis, primates
Summary of Study: The reviewers argue that advanced imaging tools add unique insight into poorly understood relationships of SARS-CV-2 exposure, infection, the host response, and disease presentation in the lungs.
References: PMID: 34955425 / doi: 10.1016/j.molmed.2021.12.001
Contact Info: Marieke Stammes: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1471491421003166?via%3Dihub
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre/The Netherlands; NIAID; University Paris-Saclay, Inserm; Tulane National Primate Research Center; University of Pittsburgh School of Medicine; University of Pittsburgh Center for Vaccine Research; Texas Biomedical Research Institute; Frederick National Laboratory for Cancer Research
Keywords: SARS-CoV-2, advanced medical imaging, pathogenesis, primates
Summary of Study: The reviewers argue that advanced imaging tools add unique insight into poorly understood relationships of SARS-CV-2 exposure, infection, the host response, and disease presentation in the lungs.
References: PMID: 34955425 / doi: 10.1016/j.molmed.2021.12.001
Contact Info: Marieke Stammes: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1471491421003166?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine; Nanchang University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, CRISPR-RT–PCR assay, longitudinal analysis, mucosal, plasma, and breath samples, primates
Summary of Study: CRISPR-FDS may provide a means to evaluate systemic viral/viral RNA burden not detectable by RT-qPCR to improve diagnosis and better predict outcomes for SARS-CoV-2 infections.
References: PMID: 35108153 / doi: 10.1080/22221751.2038020
Contact Info: Tony Hu: tonyhu2tulane.edu
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2038020
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine; Nanchang University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, CRISPR-RT–PCR assay, longitudinal analysis, mucosal, plasma, and breath samples, primates
Summary of Study: CRISPR-FDS may provide a means to evaluate systemic viral/viral RNA burden not detectable by RT-qPCR to improve diagnosis and better predict outcomes for SARS-CoV-2 infections.
References: PMID: 35108153 / doi: 10.1080/22221751.2038020
Contact Info: Tony Hu: tonyhu2tulane.edu
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2038020
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; University of California, Irvine
Keywords: SARS-CoV-2, Vesicular Stomatitis Virus-Based Vaccine, route of administration, immune response, primates
Summary of Study: The VSV-SARS2-EBOV vaccine presents a vaccine with a high potential as a boosting option after the already-approved mRNA-based vaccine, because VSV-SARS2-EBOV elicits primarily a humoral response, in contrast to the predominantly T cell-driven immune response after mRNA vaccination.
References: PMID: 35012339 / doi: 10.1128/mbio.03379-21
Contact Info: Andrea Marzi: [email protected]
URL: https://journals.asm.org/doi/full/10.1128/mbio.03379-21?rfr_dat=cr_pub++0pubmed…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; University of California, Irvine
Keywords: SARS-CoV-2, Vesicular Stomatitis Virus-Based Vaccine, route of administration, immune response, primates
Summary of Study: The VSV-SARS2-EBOV vaccine presents a vaccine with a high potential as a boosting option after the already-approved mRNA-based vaccine, because VSV-SARS2-EBOV elicits primarily a humoral response, in contrast to the predominantly T cell-driven immune response after mRNA vaccination.
References: PMID: 35012339 / doi: 10.1128/mbio.03379-21
Contact Info: Andrea Marzi: [email protected]
URL: https://journals.asm.org/doi/full/10.1128/mbio.03379-21?rfr_dat=cr_pub++0pubmed…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Institute of Infectious Diseases, Tokyo; Kumamoto University; ID Pharma Co., Ltd.
Keywords: SARS-CoV-2, intranasal vaccine, non-S antigens, immune response, primates
Summary of Study: CD8+ T cell induction by intranasal vaccination with a vaccine expressing viral non-S antigens can result in NAb-independent control of SARS-CoV-2 infection.
References: PMID: 35233545 / doi: 10.1016/j.xcrm.2022.100520
Contact Info: Tetsuro Matano: [email protected]
URL: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00020-9?_retu…
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Institute of Infectious Diseases, Tokyo; Kumamoto University; ID Pharma Co., Ltd.
Keywords: SARS-CoV-2, intranasal vaccine, non-S antigens, immune response, primates
Summary of Study: CD8+ T cell induction by intranasal vaccination with a vaccine expressing viral non-S antigens can result in NAb-independent control of SARS-CoV-2 infection.
References: PMID: 35233545 / doi: 10.1016/j.xcrm.2022.100520
Contact Info: Tetsuro Matano: [email protected]
URL: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00020-9?_retu…
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Illinois College of Medicine
Keywords: SARS-CoV-2, transcriptomic profiling, lung endothelial cells, primates
Summary of Study: The specific genes that distinguished immuneEC and devEC populations in the NHP lungs after SARS-CoV-2 infection were different from the endotoxemic mouse lung. This may reflect either species differences or different injury-specific responses (bacterial endotoxin vs. SARS-CoV-2).
References: PMID: 35511435 / doi: 10.1172/jci.insight.158079
Contact Info: Lianghui Zhang: [email protected]; Jalees Rehman: [email protected]
URL: https://insight.jci.org/articles/view/158079
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Illinois College of Medicine
Keywords: SARS-CoV-2, transcriptomic profiling, lung endothelial cells, primates
Summary of Study: The specific genes that distinguished immuneEC and devEC populations in the NHP lungs after SARS-CoV-2 infection were different from the endotoxemic mouse lung. This may reflect either species differences or different injury-specific responses (bacterial endotoxin vs. SARS-CoV-2).
References: PMID: 35511435 / doi: 10.1172/jci.insight.158079
Contact Info: Lianghui Zhang: [email protected]; Jalees Rehman: [email protected]
URL: https://insight.jci.org/articles/view/158079
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Fred Hutchinson Cancer Research Center; Department of Medicine, University of Washington
Keywords: SARS-CoV-2, remdesivir, math modeling, antiviral potency, nasal passages, lungs, primates
Summary of Study: In rhesus macaques, the nonlinear forces governing SARS-CoV-2 viral load trajectories in the lung and nasal passages differ substantially in the presence of a partially effective antiviral therapy. To the extent that the rhesus macaque model approximates human infection, nasal viral load remains a promising surrogate endpoint marker but perhaps only in the context of a highly potent antiviral therapy.
References: PMID: 35634576 / doi: 10.1016/j.isci.2022.104448
Contact Info: Joshua Schiffer: [email protected]
URL: https://www.cell.com/iscience/fulltext/S2589-0042(22)00719-2?_returnURL=https%3…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Fred Hutchinson Cancer Research Center; Department of Medicine, University of Washington
Keywords: SARS-CoV-2, remdesivir, math modeling, antiviral potency, nasal passages, lungs, primates
Summary of Study: In rhesus macaques, the nonlinear forces governing SARS-CoV-2 viral load trajectories in the lung and nasal passages differ substantially in the presence of a partially effective antiviral therapy. To the extent that the rhesus macaque model approximates human infection, nasal viral load remains a promising surrogate endpoint marker but perhaps only in the context of a highly potent antiviral therapy.
References: PMID: 35634576 / doi: 10.1016/j.isci.2022.104448
Contact Info: Joshua Schiffer: [email protected]
URL: https://www.cell.com/iscience/fulltext/S2589-0042(22)00719-2?_returnURL=https%3…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shionogi & Co., Ltd.; Department of Pathology and Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan
Keywords: SARS-CoV-2, recombinant S-protein vaccine S-268019-b, immune response, primates
Summary of Study: Immunogenicity and protective efficacy of SARS-CoV-2 recombinant S-protein vaccine S-268019-b in cynomolgus monkeys
References: PMID: 35691872 PMCID: PMC9167832 DOI: 10.1016/j.vaccine.22.05.081
Contact Info: Hideki Hasegawa: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22007186?via%3Dihub
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shionogi & Co., Ltd.; Department of Pathology and Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan
Keywords: SARS-CoV-2, recombinant S-protein vaccine S-268019-b, immune response, primates
Summary of Study: Immunogenicity and protective efficacy of SARS-CoV-2 recombinant S-protein vaccine S-268019-b in cynomolgus monkeys
References: PMID: 35691872 PMCID: PMC9167832 DOI: 10.1016/j.vaccine.22.05.081
Contact Info: Hideki Hasegawa: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22007186?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shanghai Zerun Biotech Co., Ltd.; numerous others
Keywords: SARS-CoV-2, recombinant vaccine, immunogenicity, virus variants, hamster, primates
Summary of Study: A potent, broadly protective vaccine against SARS-CoV-2 variants of concern.
References: doi: 10.1038/s41541-022-00571-0
Contact Info: Chenliang Zhou: [email protected]
URL: https://www.nature.com/articles/s41541-022-00571-0
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shanghai Zerun Biotech Co., Ltd.; numerous others
Keywords: SARS-CoV-2, recombinant vaccine, immunogenicity, virus variants, hamster, primates
Summary of Study: A potent, broadly protective vaccine against SARS-CoV-2 variants of concern.
References: doi: 10.1038/s41541-022-00571-0
Contact Info: Chenliang Zhou: [email protected]
URL: https://www.nature.com/articles/s41541-022-00571-0
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences; Fudan University; Shanghai King-Cell Biotechnology Co., Ltd.; Mabwell Bioscience Co., Ltd.; Shenzhen University; University of Chinese Academy of Sciences
Keywords: SARS-CoV-2, self-adjuvanting peptide vaccine, CoVac501, immune response, virus variants, primates
Summary of Study: CoVac501, a novel SARS-CoV-2 vaccine that is fully chemically synthesized and self-adjuvanting, provided potent protection for cynomolgus macaques against challenges from very high doses of SARS-CoV-2.
References: PMID: 35102138 / doi: 10.1038/s41421-021-00370-2
Contact Info: Qiuping Qin: [email protected]
URL: https://www.nature.com/articles/s41421-021-00370-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences; Fudan University; Shanghai King-Cell Biotechnology Co., Ltd.; Mabwell Bioscience Co., Ltd.; Shenzhen University; University of Chinese Academy of Sciences
Keywords: SARS-CoV-2, self-adjuvanting peptide vaccine, CoVac501, immune response, virus variants, primates
Summary of Study: CoVac501, a novel SARS-CoV-2 vaccine that is fully chemically synthesized and self-adjuvanting, provided potent protection for cynomolgus macaques against challenges from very high doses of SARS-CoV-2.
References: PMID: 35102138 / doi: 10.1038/s41421-021-00370-2
Contact Info: Qiuping Qin: [email protected]
URL: https://www.nature.com/articles/s41421-021-00370-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Pfizer; Icahn School of Medicine at Mount Sinai; Texas Biomedical Research Institute; New Iberia Research Center
Keywords: SARS-CoV-2, pathology, inflammation, Golden Syrian Hamster, primates
Summary of Study: Macaques may be appropriate for mechanistic studies of mild asymptomatic COVID-19 pneumonia and COVID-19-associated encephalitis, whereas Syrian hamsters may be more suited to study severe COVID-19 pneumonia.
References: PMID: 35128980 / doi: 10.1177/01926233211072767
Contact Info: Shambhunath Choudhary: [email protected]
URL: https://journals.sagepub.com/doi/full/10.1177/01926233211072767?rfr_dat=cr_pub+…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Pfizer; Icahn School of Medicine at Mount Sinai; Texas Biomedical Research Institute; New Iberia Research Center
Keywords: SARS-CoV-2, pathology, inflammation, Golden Syrian Hamster, primates
Summary of Study: Macaques may be appropriate for mechanistic studies of mild asymptomatic COVID-19 pneumonia and COVID-19-associated encephalitis, whereas Syrian hamsters may be more suited to study severe COVID-19 pneumonia.
References: PMID: 35128980 / doi: 10.1177/01926233211072767
Contact Info: Shambhunath Choudhary: [email protected]
URL: https://journals.sagepub.com/doi/full/10.1177/01926233211072767?rfr_dat=cr_pub+…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; Tongji Medical College of Huazhong University of Science & Technology
Keywords: SARS-CoV-2, infection, pathogenesis, virus variants, primates
Summary of Study: Delta variant of SARS-CoV-2 can effectively infect the Rhesus macaque.
References: PMID: 35279412 / doi: 10.1016/j.virs.2022.02.001
Contact Info: Zhiming Yuan: [email protected]; Chao Shan: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1995820X22000335?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; Tongji Medical College of Huazhong University of Science & Technology
Keywords: SARS-CoV-2, infection, pathogenesis, virus variants, primates
Summary of Study: Delta variant of SARS-CoV-2 can effectively infect the Rhesus macaque.
References: PMID: 35279412 / doi: 10.1016/j.virs.2022.02.001
Contact Info: Zhiming Yuan: [email protected]; Chao Shan: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1995820X22000335?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Fred Hutchinson Cancer Research Center; University of Washington; HDT Bio; NIAID; Washington National Primate Research Center
Keywords: SARS-CoV-2, phage-based deep mutational scanning, immune response, vaccination, primates
Summary of Study: Findings suggest that the antibody response to SARS-CoV-2 in macaques shares many features with humans, but with substantial differences in the recognition of certain epitopes and considerable individual variability in antibody escape profiles, suggesting a diverse repertoire of antibodies that can respond to major epitopes in both humans and macaques.
References: PMID: 35404959 / doi: 10.1371/journal.ppat.1010155
Contact Info: Julie Overbaugh: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010155
NHP Species: pigtail macaques, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Fred Hutchinson Cancer Research Center; University of Washington; HDT Bio; NIAID; Washington National Primate Research Center
Keywords: SARS-CoV-2, phage-based deep mutational scanning, immune response, vaccination, primates
Summary of Study: Findings suggest that the antibody response to SARS-CoV-2 in macaques shares many features with humans, but with substantial differences in the recognition of certain epitopes and considerable individual variability in antibody escape profiles, suggesting a diverse repertoire of antibodies that can respond to major epitopes in both humans and macaques.
References: PMID: 35404959 / doi: 10.1371/journal.ppat.1010155
Contact Info: Julie Overbaugh: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010155