Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine; Nanchang University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, CRISPR-RT–PCR assay, longitudinal analysis, mucosal, plasma, and breath samples, primates
Summary of Study: CRISPR-FDS may provide a means to evaluate systemic viral/viral RNA burden not detectable by RT-qPCR to improve diagnosis and better predict outcomes for SARS-CoV-2 infections.
References: PMID: 35108153 / doi: 10.1080/22221751.2038020
Contact Info: Tony Hu: tonyhu2tulane.edu
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2038020
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine; Nanchang University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, CRISPR-RT–PCR assay, longitudinal analysis, mucosal, plasma, and breath samples, primates
Summary of Study: CRISPR-FDS may provide a means to evaluate systemic viral/viral RNA burden not detectable by RT-qPCR to improve diagnosis and better predict outcomes for SARS-CoV-2 infections.
References: PMID: 35108153 / doi: 10.1080/22221751.2038020
Contact Info: Tony Hu: tonyhu2tulane.edu
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2038020
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: MIT; Scripps Research Institute; La Jolla Institute for Immunology; Ragon Institute of Massachusetts General Hospital, MIT, and Harvard University; University of California, San Diego; Yerkes National Primate Research Center; Emory University School of Medicine; MIT
Keywords: SARS-CoV-2, saponin/TLR agonist, vaccine adjuvant, immune response, primates
Summary of Study: Compared with a panel of tested adjuvants including other saponin-based formulations, saponin/MPLA nanoparticles (SMNP) induced superior antibody and germinal center responses after immunization with a poorly immunogenic HIV antigen in both mice and rhesus macaques, suggesting that SMNP may be a promising adjuvant in the setting of HIV, SARS-CoV-2, and other pathogens.
References: PMID: 34860581 / doi: 10.1126/sciimmunol.abf1152
Contact Info: Darrell J. Irvine: [email protected]; Shane Crotty: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.abf1152?url_ver=Z39.88-2003&rfr_…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: MIT; Scripps Research Institute; La Jolla Institute for Immunology; Ragon Institute of Massachusetts General Hospital, MIT, and Harvard University; University of California, San Diego; Yerkes National Primate Research Center; Emory University School of Medicine; MIT
Keywords: SARS-CoV-2, saponin/TLR agonist, vaccine adjuvant, immune response, primates
Summary of Study: Compared with a panel of tested adjuvants including other saponin-based formulations, saponin/MPLA nanoparticles (SMNP) induced superior antibody and germinal center responses after immunization with a poorly immunogenic HIV antigen in both mice and rhesus macaques, suggesting that SMNP may be a promising adjuvant in the setting of HIV, SARS-CoV-2, and other pathogens.
References: PMID: 34860581 / doi: 10.1126/sciimmunol.abf1152
Contact Info: Darrell J. Irvine: [email protected]; Shane Crotty: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.abf1152?url_ver=Z39.88-2003&rfr_…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of California, Davis, School of Medicine
Keywords: SARS-CoV-2, pre-existing HIV infection, gene expression, metabolomics, primates
Summary of Study: SIV infection resulted in sustained or increased ACE2 expression in an inflamed and immune-impaired gut mucosal microenvironment.
References: PMID: 35495669 / doi: 10.3389/fmicb.2022.879152
Contact Info: Satya Dandekar: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2022.879152/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of California, Davis, School of Medicine
Keywords: SARS-CoV-2, pre-existing HIV infection, gene expression, metabolomics, primates
Summary of Study: SIV infection resulted in sustained or increased ACE2 expression in an inflamed and immune-impaired gut mucosal microenvironment.
References: PMID: 35495669 / doi: 10.3389/fmicb.2022.879152
Contact Info: Satya Dandekar: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2022.879152/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Peking Union Medical College; National Center of Technology Innovation for Animal Model; Chinese Academy of Sciences; Capital Medical University
Keywords: SARS-CoV-2, inactivated vaccine, booster, immune response, virus variants, primates
Summary of Study: Animals administered with an indicated booster dose and subsequently challenged with Delta or Omicron variants showed markedly reduced viral loads and improved histopathological profiles compared to control animals, indicating that sequential immunization could protect primates against Omicron.
References: PMID: 35436986 / doi: 10.1038/s41392-022-00979-z
Contact Info: Chuan Qin: [email protected];
URL: https://www.nature.com/articles/s41392-022-00979-z
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Peking Union Medical College; National Center of Technology Innovation for Animal Model; Chinese Academy of Sciences; Capital Medical University
Keywords: SARS-CoV-2, inactivated vaccine, booster, immune response, virus variants, primates
Summary of Study: Animals administered with an indicated booster dose and subsequently challenged with Delta or Omicron variants showed markedly reduced viral loads and improved histopathological profiles compared to control animals, indicating that sequential immunization could protect primates against Omicron.
References: PMID: 35436986 / doi: 10.1038/s41392-022-00979-z
Contact Info: Chuan Qin: [email protected];
URL: https://www.nature.com/articles/s41392-022-00979-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; University of California, San Diego; University of Cape Town, Observatory, South Africa
Keywords: SARS-CoV-2, mild infection, pathology, immune response, primates
Summary of Study: SARS-CoV-2 replication wanes in the lungs, as well as the nasal and oral mucosa, of rhesus macaques before antigen-specific effector T cells arrive at those sites, suggesting that innate immunity efficiently restricts viral replication during mild COVID-19.
References: PMID: 35271298 / doi: 10.1126/sciimmunol.abo0535
Contact Info: Daniel Barber: [email protected]
URL: https://www.science.org/doi/full/10.1126/sciimmunol.abo0535?rfr_dat=cr_pub%20%2…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; University of California, San Diego; University of Cape Town, Observatory, South Africa
Keywords: SARS-CoV-2, mild infection, pathology, immune response, primates
Summary of Study: SARS-CoV-2 replication wanes in the lungs, as well as the nasal and oral mucosa, of rhesus macaques before antigen-specific effector T cells arrive at those sites, suggesting that innate immunity efficiently restricts viral replication during mild COVID-19.
References: PMID: 35271298 / doi: 10.1126/sciimmunol.abo0535
Contact Info: Daniel Barber: [email protected]
URL: https://www.science.org/doi/full/10.1126/sciimmunol.abo0535?rfr_dat=cr_pub%20%2…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Sanofi R&D; Universite de Strasbourg; Equipe 3Bio
Keywords: SARS-CoV-2, mRNA vaccine, lipid nanoparticles, stability, mice, primates
Summary of Study: The thermostability of mRNA/LNP is improved by a novel imidazole modified lipid, DOG-IM4, in combination with standard helper lipids.
References: PMID: 35576809 / doi: 10.1016/j.biomaterials.2022.121570
Contact Info: Jean Haensler: [email protected];
URL: https://www.sciencedirect.com/science/article/pii/S0142961222002101?via%3Dihub=
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Sanofi R&D; Universite de Strasbourg; Equipe 3Bio
Keywords: SARS-CoV-2, mRNA vaccine, lipid nanoparticles, stability, mice, primates
Summary of Study: The thermostability of mRNA/LNP is improved by a novel imidazole modified lipid, DOG-IM4, in combination with standard helper lipids.
References: PMID: 35576809 / doi: 10.1016/j.biomaterials.2022.121570
Contact Info: Jean Haensler: [email protected];
URL: https://www.sciencedirect.com/science/article/pii/S0142961222002101?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Zhongshan School of Medicine; Qianyang Biomedical Research Institute; Guangdong Provincial Center for Disease Control and Prevention
Keywords: SARS-CoV-2, bivalent vaccine, D614G/B.1.351, vaccine dosage, mice, primates
Summary of Study: With a prime-boost or single-dose strategy a bivalent D614G/B.1.351 RBD nanoparticle vaccine elicited robust nAbs and full protection against infection with the authentic D614 or B.1.351 strains in human ACE2 transgene mice. Furthermore, 8 months after inoculation with the D614G-specific vaccine, a new boost with this bivalent vaccine potently elicited cross-nAbs for SARS-CoV-2 variants in rhesus macaques.
References: PMID: 34990583 / doi: 10.1016/j.celrep.2021.110256
Contact Info: Yiwen Zhang: [email protected]; Hui Zhang: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S221112472101768X?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Zhongshan School of Medicine; Qianyang Biomedical Research Institute; Guangdong Provincial Center for Disease Control and Prevention
Keywords: SARS-CoV-2, bivalent vaccine, D614G/B.1.351, vaccine dosage, mice, primates
Summary of Study: With a prime-boost or single-dose strategy a bivalent D614G/B.1.351 RBD nanoparticle vaccine elicited robust nAbs and full protection against infection with the authentic D614 or B.1.351 strains in human ACE2 transgene mice. Furthermore, 8 months after inoculation with the D614G-specific vaccine, a new boost with this bivalent vaccine potently elicited cross-nAbs for SARS-CoV-2 variants in rhesus macaques.
References: PMID: 34990583 / doi: 10.1016/j.celrep.2021.110256
Contact Info: Yiwen Zhang: [email protected]; Hui Zhang: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S221112472101768X?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Emergent BioSolutions; Yoh Services LLC; Sanofi Pasteur; Translate Bio; UT Health Science Center at Houston
Keywords: SARS-CoV-2, virus variants, vaccine, boost, neutralizing effects, primates
Summary of Study: This study showed that a third vaccination administered as a booster, regardless of composition, to the currently approved two dose regimens could effectively promote broadly neutralizing antibodies against all variants of concern.
References: PMID: 35101265 / doi: 10.1016/j.vaccine.2022.01.021
Contact Info: Natalie Anosova: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22000457?via%3Dihub=
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Emergent BioSolutions; Yoh Services LLC; Sanofi Pasteur; Translate Bio; UT Health Science Center at Houston
Keywords: SARS-CoV-2, virus variants, vaccine, boost, neutralizing effects, primates
Summary of Study: This study showed that a third vaccination administered as a booster, regardless of composition, to the currently approved two dose regimens could effectively promote broadly neutralizing antibodies against all variants of concern.
References: PMID: 35101265 / doi: 10.1016/j.vaccine.2022.01.021
Contact Info: Natalie Anosova: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22000457?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Medicago Inc.; Stanford University School of Medicine; Tulane National Primate Research Center; Tulane University School of Medicine; Research Institute of the McGill University Health Centre
Keywords: SARS-CoV-2, unadjuvanted and adjuvanted formulations, recombinant plant-derived virus-like particle vaccine, safety, immune response, primates
Summary of Study: A VLP bearing a SARS-CoV-2 spike protein vaccine candidate formulated with Adjuvant System 03 (AS03) was shown to be safe and effective and was therefore selected for vaccine development and clinical trials.
References: PMID: 34983950 / doi: 10.1038/s41423-021-00809-2
Contact Info: Brian Ward: [email protected]
URL: https://www.nature.com/articles/s41423-021-00809-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Medicago Inc.; Stanford University School of Medicine; Tulane National Primate Research Center; Tulane University School of Medicine; Research Institute of the McGill University Health Centre
Keywords: SARS-CoV-2, unadjuvanted and adjuvanted formulations, recombinant plant-derived virus-like particle vaccine, safety, immune response, primates
Summary of Study: A VLP bearing a SARS-CoV-2 spike protein vaccine candidate formulated with Adjuvant System 03 (AS03) was shown to be safe and effective and was therefore selected for vaccine development and clinical trials.
References: PMID: 34983950 / doi: 10.1038/s41423-021-00809-2
Contact Info: Brian Ward: [email protected]
URL: https://www.nature.com/articles/s41423-021-00809-2
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: MIT; Harvard Medical School; University of Kansas; Tufts University; SpyBiotech Limited; Bioqual; Bill and Melinda Gates Medical Research Institute; Serum Institute of India; University of Oxford; Ragon Institute of MGH, MIT, and Harvard; Massachusetts Consortium on Pathogen Readiness
Keywords: SARS-CoV-2, receptor binding domain, HBsAg virus–like particles, immune response, primates
Summary of Study: A clinical-stage vaccine candidate comprising a SARS-CoV-2 receptor binding domain-hepatitis B surface antigen virus-like particle elicited protective immunity in cynomolgus macaques.
References: PMID: 35294244 / doi: 10.1126/sciadv.abl6015
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.abl6015?url_ver=Z39.88-2003&rfr_id=o…
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: MIT; Harvard Medical School; University of Kansas; Tufts University; SpyBiotech Limited; Bioqual; Bill and Melinda Gates Medical Research Institute; Serum Institute of India; University of Oxford; Ragon Institute of MGH, MIT, and Harvard; Massachusetts Consortium on Pathogen Readiness
Keywords: SARS-CoV-2, receptor binding domain, HBsAg virus–like particles, immune response, primates
Summary of Study: A clinical-stage vaccine candidate comprising a SARS-CoV-2 receptor binding domain-hepatitis B surface antigen virus-like particle elicited protective immunity in cynomolgus macaques.
References: PMID: 35294244 / doi: 10.1126/sciadv.abl6015
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.abl6015?url_ver=Z39.88-2003&rfr_id=o…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: prevention
NPRC/Institute: AstraZeneca; BIOQUAL; Vanderbilt University; USAMRIID
Keywords: SARS-CoV-2, monoclonal antibody combination, AZD7442,virus protection, humans, primates
Summary of Study: AZD7442, a monoclonal antibody comprised of AZD8895 and AZD1061, demonstrated potent in vitro neutralization against SARS-CoV-2 VOCs, in vivo efficacy in both prevention and treatment settings of SARS-CoV-2 infection in NHPs, and extended half-life in NHPs and healthy adult participants.
References: PMID: 35076282 / doi: 10.1126/scitranslmed.abl8124
Contact Info: Mark Esser: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abl8124?url_ver=Z39.88-2003&rf…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: prevention
NPRC/Institute: AstraZeneca; BIOQUAL; Vanderbilt University; USAMRIID
Keywords: SARS-CoV-2, monoclonal antibody combination, AZD7442,virus protection, humans, primates
Summary of Study: AZD7442, a monoclonal antibody comprised of AZD8895 and AZD1061, demonstrated potent in vitro neutralization against SARS-CoV-2 VOCs, in vivo efficacy in both prevention and treatment settings of SARS-CoV-2 infection in NHPs, and extended half-life in NHPs and healthy adult participants.
References: PMID: 35076282 / doi: 10.1126/scitranslmed.abl8124
Contact Info: Mark Esser: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abl8124?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Northwestern University; Tulane National Primate Research Center; NIAID; Sanford Burnham Prebys Medical Discovery Institute; Bioqual; New Iberia Research Center
Keywords: SARS-CoV-2, antibody-based in vivo probe system, lungs, primates
Summary of Study: Results provide proof of concept for the use of in vivo antibody-based probes to study SARS-CoV-2 infection dynamics in rhesus macaques.
References: PMID: 35003140 / doi: 10.3389/fimmu.2021.810047
Contact Info: Thomas Hope: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.810047/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Northwestern University; Tulane National Primate Research Center; NIAID; Sanford Burnham Prebys Medical Discovery Institute; Bioqual; New Iberia Research Center
Keywords: SARS-CoV-2, antibody-based in vivo probe system, lungs, primates
Summary of Study: Results provide proof of concept for the use of in vivo antibody-based probes to study SARS-CoV-2 infection dynamics in rhesus macaques.
References: PMID: 35003140 / doi: 10.3389/fimmu.2021.810047
Contact Info: Thomas Hope: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.810047/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, longitudinal analyses, lungs, intestines, immune response, primates
Summary of Study: Findings indicate an imbalance of immune dynamic in intestinal mucosa during SARS-CoV-2 infection, which may underlie ongoing rectal viral shedding and mild tissue damage.
References: PMID: 35594870 / doi: 10.1016/j.celrep.2022.110864
Contact Info: Zhanlong He: [email protected]; Haijing Shi: [email protected]; Qihan Li: [email protected]; Longing Liu: [email protected]
URL: https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00637-4?_returnURL=htt…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, longitudinal analyses, lungs, intestines, immune response, primates
Summary of Study: Findings indicate an imbalance of immune dynamic in intestinal mucosa during SARS-CoV-2 infection, which may underlie ongoing rectal viral shedding and mild tissue damage.
References: PMID: 35594870 / doi: 10.1016/j.celrep.2022.110864
Contact Info: Zhanlong He: [email protected]; Haijing Shi: [email protected]; Qihan Li: [email protected]; Longing Liu: [email protected]
URL: https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00637-4?_returnURL=htt…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; China Agricultural University; Capital Medical University; University of Science & Technology of China; Chinese Academy of Medical Sciences and Peking Union Medical College; Chinese Center for Disease Control and Prevention
Keywords: SARS-CoV-2, human neutralizing antibodies, virus variants, mice, primates
Summary of Study: bsAB15 was developed and shown to efficiently neutralize all single-mAb escape mutants. This bsAb is a feasible and effective strategy to treat and prevent severe COVID-19.
References: PMID: 35228696 / doi: 10.1038/s41590-022-01138-w
Contact Info: Yan Wu: [email protected]; Feng Gao: [email protected]
URL: https://www.nature.com/articles/s41590-022-01138-w
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; China Agricultural University; Capital Medical University; University of Science & Technology of China; Chinese Academy of Medical Sciences and Peking Union Medical College; Chinese Center for Disease Control and Prevention
Keywords: SARS-CoV-2, human neutralizing antibodies, virus variants, mice, primates
Summary of Study: bsAB15 was developed and shown to efficiently neutralize all single-mAb escape mutants. This bsAb is a feasible and effective strategy to treat and prevent severe COVID-19.
References: PMID: 35228696 / doi: 10.1038/s41590-022-01138-w
Contact Info: Yan Wu: [email protected]; Feng Gao: [email protected]
URL: https://www.nature.com/articles/s41590-022-01138-w
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Ology Bioservices; Harvard Medical School, Vanderbilt University Medical Center; US Department of Defense; Logistics Management Institute; Washington University School of Medicine; Bioqual, Inc.
Keywords: SARS-CoV-2, neutralizing human monoclonal antibodies, primates
Summary of Study: Neutralizing antibodies with extended half-life and lacking Fc-mediated effector functions are efficient for pre-exposure prophylaxis of SARS-CoV-2 infection in NHPs.
References: PMID: 35132398 / doi: 10.1016/j.medj.2022.01.004
Contact Info: Dan Barouch: [email protected]
URL: https://www.cell.com/med/fulltext/S2666-6340(22)00039-3?_returnURL=https%3A//li…
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Ology Bioservices; Harvard Medical School, Vanderbilt University Medical Center; US Department of Defense; Logistics Management Institute; Washington University School of Medicine; Bioqual, Inc.
Keywords: SARS-CoV-2, neutralizing human monoclonal antibodies, primates
Summary of Study: Neutralizing antibodies with extended half-life and lacking Fc-mediated effector functions are efficient for pre-exposure prophylaxis of SARS-CoV-2 infection in NHPs.
References: PMID: 35132398 / doi: 10.1016/j.medj.2022.01.004
Contact Info: Dan Barouch: [email protected]
URL: https://www.cell.com/med/fulltext/S2666-6340(22)00039-3?_returnURL=https%3A//li…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Institute of Infectious Diseases, Tokyo; Kumamoto University; ID Pharma Co., Ltd.
Keywords: SARS-CoV-2, intranasal vaccine, non-S antigens, immune response, primates
Summary of Study: CD8+ T cell induction by intranasal vaccination with a vaccine expressing viral non-S antigens can result in NAb-independent control of SARS-CoV-2 infection.
References: PMID: 35233545 / doi: 10.1016/j.xcrm.2022.100520
Contact Info: Tetsuro Matano: [email protected]
URL: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00020-9?_retu…
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Institute of Infectious Diseases, Tokyo; Kumamoto University; ID Pharma Co., Ltd.
Keywords: SARS-CoV-2, intranasal vaccine, non-S antigens, immune response, primates
Summary of Study: CD8+ T cell induction by intranasal vaccination with a vaccine expressing viral non-S antigens can result in NAb-independent control of SARS-CoV-2 infection.
References: PMID: 35233545 / doi: 10.1016/j.xcrm.2022.100520
Contact Info: Tetsuro Matano: [email protected]
URL: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00020-9?_retu…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Ragon Institution of MGH, MIT, and Harvard; Bioqual; Washington University School of Medicine; Emory School of Medicine, Tufts University Cummings School of Veterinary Medicine
Keywords: SARS-CoV-2, mRNA-based BNT162b2 vaccine, virus variants, immune response, primates
Summary of Study: BNT162b2 and Ad26.COV2.S provided robust protection against high-dose challenge with the SARS-CoV-2 Omicron variant in macaques. Protection against this highly mutated SARS-CoV-2 variant correlated with both humoral and cellular immune responses.
References: PMID: 35169798 / doi: 10.1101/2022.02.06.479285
Contact Info: Dan Barouch: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.02.06.479285v1
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Ragon Institution of MGH, MIT, and Harvard; Bioqual; Washington University School of Medicine; Emory School of Medicine, Tufts University Cummings School of Veterinary Medicine
Keywords: SARS-CoV-2, mRNA-based BNT162b2 vaccine, virus variants, immune response, primates
Summary of Study: BNT162b2 and Ad26.COV2.S provided robust protection against high-dose challenge with the SARS-CoV-2 Omicron variant in macaques. Protection against this highly mutated SARS-CoV-2 variant correlated with both humoral and cellular immune responses.
References: PMID: 35169798 / doi: 10.1101/2022.02.06.479285
Contact Info: Dan Barouch: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.02.06.479285v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tsinghua University; Chongqing Medical University; Boston University School of Medicine; Chinese Academy of Sciences; Shenzhen Bay Laboratory; Peking University Shenshen Graduate School; Fudan University
Keywords: SARS-CoV-2, pathogenesis, neutralization antibodies, primates
Summary of Study: Kappa, Delta, or B.1.618 spike uses human angiotensin-converting enzyme 2 (ACE2) with no or slightly increased efficiency, while it gains a significantly increased binding affinity with mouse, marmoset, and koala ACE2 orthologs, which exhibit limited binding with wild-type (WT) spike. Collectively, this study revealed that enhanced human and mouse ASE receptor engagement, increased spike cleavage, and reduced sensitivity to neutralization antibodies of Kapa, Delta and B.1.618 may contribute to the rapid spread of these variants.
References: PMID: 35266815 / doi: 10.1128/mbio.00099-22
Contact Info: Qiang Ding: [email protected]
URL: https://journals.asm.org/doi/full/10.1128/mbio.00099-22?rfr_dat=cr_pub%20%200pu…
NHP Species: marmosets
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tsinghua University; Chongqing Medical University; Boston University School of Medicine; Chinese Academy of Sciences; Shenzhen Bay Laboratory; Peking University Shenshen Graduate School; Fudan University
Keywords: SARS-CoV-2, pathogenesis, neutralization antibodies, primates
Summary of Study: Kappa, Delta, or B.1.618 spike uses human angiotensin-converting enzyme 2 (ACE2) with no or slightly increased efficiency, while it gains a significantly increased binding affinity with mouse, marmoset, and koala ACE2 orthologs, which exhibit limited binding with wild-type (WT) spike. Collectively, this study revealed that enhanced human and mouse ASE receptor engagement, increased spike cleavage, and reduced sensitivity to neutralization antibodies of Kapa, Delta and B.1.618 may contribute to the rapid spread of these variants.
References: PMID: 35266815 / doi: 10.1128/mbio.00099-22
Contact Info: Qiang Ding: [email protected]
URL: https://journals.asm.org/doi/full/10.1128/mbio.00099-22?rfr_dat=cr_pub%20%200pu…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: diagnostics
NPRC/Institute: Universite Paris-Saclay, Inserm, CEA; Sorbonne Universite; BioPredictive; Institut Pasteur
Keywords: SARS-CoV-2, blood test, diagnostics, primates
Summary of Study: Results validate the diagnostic and prognostic performances of A1HPV6 in patients infected by SARS-CoV-2, not hospitalized in ICU. These results are reinforced by similar kinetics of A1, HP, and A2M observed in the macaque model.
References: PMID: 35174366 / doi: 10.1016/j.gastha.2021.12.009
Contact Info: Thierry Poynard: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818442/
NHP Species:
Year Published: 2022
Study Type/Review: diagnostics
NPRC/Institute: Universite Paris-Saclay, Inserm, CEA; Sorbonne Universite; BioPredictive; Institut Pasteur
Keywords: SARS-CoV-2, blood test, diagnostics, primates
Summary of Study: Results validate the diagnostic and prognostic performances of A1HPV6 in patients infected by SARS-CoV-2, not hospitalized in ICU. These results are reinforced by similar kinetics of A1, HP, and A2M observed in the macaque model.
References: PMID: 35174366 / doi: 10.1016/j.gastha.2021.12.009
Contact Info: Thierry Poynard: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818442/
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine
Keywords: SARS-CoV-2, virus genome, gut, virus evolution, primates
Summary of Study: Previous reports that an intact furin cleavage site is important for infection in vivo were confirmed in this study. Additionally, three mutations were identified that may represent an adaptation of SARS-CoV2 to African green monkeys or to NHP generally.
References: PMID: 35062281 / doi: 10.3390/v14010077
Contact Info: Nicholas Maness: [email protected]
URL: https://www.mdpi.com/1999-4915/14/1/77
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine
Keywords: SARS-CoV-2, virus genome, gut, virus evolution, primates
Summary of Study: Previous reports that an intact furin cleavage site is important for infection in vivo were confirmed in this study. Additionally, three mutations were identified that may represent an adaptation of SARS-CoV2 to African green monkeys or to NHP generally.
References: PMID: 35062281 / doi: 10.3390/v14010077
Contact Info: Nicholas Maness: [email protected]
URL: https://www.mdpi.com/1999-4915/14/1/77
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: prevention
NPRC/Institute: University of Washington; Washington National Primate Research Center; Institute of Biomedical Sciences, Taipei; Fred Hutchinson Cancer Research Center
Keywords: SARS-CoV-2, helper-dependent adenovirus (HDAd5/35++), HSC gene therapy, safety, virus protection, mice, primates
Summary of Study: Pilot studies of a simple and portable in vivo hematopoietic HSC transduction approach that involves HSC mobilization from the bone marrow into the peripheral blood stream and the intravenous injection of an integrating, helper-dependent adenovirus vector system demonstrated safety and efficacy in mice and a rhesus macaque.
References: PMID: 35057635 / doi: 10.1089/hum.2021.295
Contact Info: Andre Lieber: [email protected]; Steve Roffler: [email protected]; Hans-Peter Kiem: [email protected]; Deborah Fuller: [email protected]
URL: https://www.liebertpub.com/doi/10.1089/hum.2021.295?url_ver=Z39.88-2003&rfr_id=…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: prevention
NPRC/Institute: University of Washington; Washington National Primate Research Center; Institute of Biomedical Sciences, Taipei; Fred Hutchinson Cancer Research Center
Keywords: SARS-CoV-2, helper-dependent adenovirus (HDAd5/35++), HSC gene therapy, safety, virus protection, mice, primates
Summary of Study: Pilot studies of a simple and portable in vivo hematopoietic HSC transduction approach that involves HSC mobilization from the bone marrow into the peripheral blood stream and the intravenous injection of an integrating, helper-dependent adenovirus vector system demonstrated safety and efficacy in mice and a rhesus macaque.
References: PMID: 35057635 / doi: 10.1089/hum.2021.295
Contact Info: Andre Lieber: [email protected]; Steve Roffler: [email protected]; Hans-Peter Kiem: [email protected]; Deborah Fuller: [email protected]
URL: https://www.liebertpub.com/doi/10.1089/hum.2021.295?url_ver=Z39.88-2003&rfr_id=…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Peking University; Chinese Academy of Medical Sciences and Peking Union Medical College; WHO Collaborating Center for Standardization and Evaluation of Biologicals
Keywords: SARS-CoV-2, circRNA vaccine, neutralizing antibodies, virus variants, primates
Summary of Study: CircRNA/RBD-Omicron vaccine induced effective neutralizing antibodies against the Omicron but not the Delta variant. In contrast, the circRNA/RBD-Delta vaccine protected against both Delta and Omicron or functioned as a booster after two doses of either native- or Delta-specific vaccination, making it a favorable choice against the current variants of concern of SARS-CoV-2.
References: PMID: 35460644 / doi: 10.1016/j.cell.2022.03.044
Contact Info: Wensheng Wei: [email protected]
URL: https://www.cell.com/cell/fulltext/S0092-8674(22)00394-4?_returnURL=https%3A//l…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Peking University; Chinese Academy of Medical Sciences and Peking Union Medical College; WHO Collaborating Center for Standardization and Evaluation of Biologicals
Keywords: SARS-CoV-2, circRNA vaccine, neutralizing antibodies, virus variants, primates
Summary of Study: CircRNA/RBD-Omicron vaccine induced effective neutralizing antibodies against the Omicron but not the Delta variant. In contrast, the circRNA/RBD-Delta vaccine protected against both Delta and Omicron or functioned as a booster after two doses of either native- or Delta-specific vaccination, making it a favorable choice against the current variants of concern of SARS-CoV-2.
References: PMID: 35460644 / doi: 10.1016/j.cell.2022.03.044
Contact Info: Wensheng Wei: [email protected]
URL: https://www.cell.com/cell/fulltext/S0092-8674(22)00394-4?_returnURL=https%3A//l…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; China National Center for Bioinformation; Capital Medical University; Chinese Academy of Medical Sciences and Peking Union Medical College; Huazhong University of Science & Technology
Keywords: SARS-CoV-2, transcriptomic profiling, virus replication, primates
Summary of Study: This study provides the transcriptome profiling of various tissues from the living primate host post SARS-CoV-2 infection. It illustrates that wide-spread transcriptomic changes involving diverse functions exist in multi-organs; an elevated immune response in cerebral cortex was the prominent feature at the early stage of SARS-CoV-2 infection.
References: PMID: 35377064 / doi: 10.1007/s13238-022-00915-5
Contact Info: Ying Yang: [email protected]; Yun-Gui Yang: [email protected]; Chuan Qin: [email protected]; Wei-Min Tong: [email protected]
URL: https://link.springer.com/article/10.1007/s13238-022-00915-5
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; China National Center for Bioinformation; Capital Medical University; Chinese Academy of Medical Sciences and Peking Union Medical College; Huazhong University of Science & Technology
Keywords: SARS-CoV-2, transcriptomic profiling, virus replication, primates
Summary of Study: This study provides the transcriptome profiling of various tissues from the living primate host post SARS-CoV-2 infection. It illustrates that wide-spread transcriptomic changes involving diverse functions exist in multi-organs; an elevated immune response in cerebral cortex was the prominent feature at the early stage of SARS-CoV-2 infection.
References: PMID: 35377064 / doi: 10.1007/s13238-022-00915-5
Contact Info: Ying Yang: [email protected]; Yun-Gui Yang: [email protected]; Chuan Qin: [email protected]; Wei-Min Tong: [email protected]
URL: https://link.springer.com/article/10.1007/s13238-022-00915-5
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Tulane National Primate Research Center
Keywords: SARS-CoV-2, noncompeting antibody cocktail, vaccine, immune response, primates
Summary of Study: A neutralizing mAB cocktail with extended half-life can be delivered intramuscularly to provide prophylactic protection against infection in rhesus macaques.
References: PMID: 35291730 / doi: 10.1016/j.medj.2022.02.004
Contact Info: Jay Rappaport: [email protected]
URL: https://www.cell.com/med/fulltext/S2666-6340(22)00087-3?_returnURL=https%3A//li…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Tulane National Primate Research Center
Keywords: SARS-CoV-2, noncompeting antibody cocktail, vaccine, immune response, primates
Summary of Study: A neutralizing mAB cocktail with extended half-life can be delivered intramuscularly to provide prophylactic protection against infection in rhesus macaques.
References: PMID: 35291730 / doi: 10.1016/j.medj.2022.02.004
Contact Info: Jay Rappaport: [email protected]
URL: https://www.cell.com/med/fulltext/S2666-6340(22)00087-3?_returnURL=https%3A//li…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; Yerkes National Primate Research Center; Emory School of Medicine; Bioqual; Modernal; Harvard T.H. Chan School of Public Health
Keywords: SARS-CoV-2, vaccination, mRNA-1273 or mRNA-Omicron boost, pathology, primates
Summary of Study: Boosting with homologous mRNA-1273 or mRNA-Omicron leads to comparable and significant increases in neutralizing antibody responses against all VOC, including Omicron.
References: PMID: 35447072 / doi: 10.1016/j.cell.2022.03.038
Contact Info: Daniel Douek: [email protected]; Robert Seder: [email protected]
URL: https://www.cell.com/cell/fulltext/S0092-8674(22)00388-9?_returnURL=https%3A//l…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; Yerkes National Primate Research Center; Emory School of Medicine; Bioqual; Modernal; Harvard T.H. Chan School of Public Health
Keywords: SARS-CoV-2, vaccination, mRNA-1273 or mRNA-Omicron boost, pathology, primates
Summary of Study: Boosting with homologous mRNA-1273 or mRNA-Omicron leads to comparable and significant increases in neutralizing antibody responses against all VOC, including Omicron.
References: PMID: 35447072 / doi: 10.1016/j.cell.2022.03.038
Contact Info: Daniel Douek: [email protected]; Robert Seder: [email protected]
URL: https://www.cell.com/cell/fulltext/S0092-8674(22)00388-9?_returnURL=https%3A//l…
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Fred Hutchinson Cancer Research Center; University of Washington; HDT Bio; NIAID; Washington National Primate Research Center
Keywords: SARS-CoV-2, phage-based deep mutational scanning, immune response, vaccination, primates
Summary of Study: Findings suggest that the antibody response to SARS-CoV-2 in macaques shares many features with humans, but with substantial differences in the recognition of certain epitopes and considerable individual variability in antibody escape profiles, suggesting a diverse repertoire of antibodies that can respond to major epitopes in both humans and macaques.
References: PMID: 35404959 / doi: 10.1371/journal.ppat.1010155
Contact Info: Julie Overbaugh: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010155
NHP Species: pigtail macaques, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Fred Hutchinson Cancer Research Center; University of Washington; HDT Bio; NIAID; Washington National Primate Research Center
Keywords: SARS-CoV-2, phage-based deep mutational scanning, immune response, vaccination, primates
Summary of Study: Findings suggest that the antibody response to SARS-CoV-2 in macaques shares many features with humans, but with substantial differences in the recognition of certain epitopes and considerable individual variability in antibody escape profiles, suggesting a diverse repertoire of antibodies that can respond to major epitopes in both humans and macaques.
References: PMID: 35404959 / doi: 10.1371/journal.ppat.1010155
Contact Info: Julie Overbaugh: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010155
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Emergent BioSolutions; Yoh Services LLC; Sanofi Pasteur; Translate Bio; UT Health Science Center at Houston
Keywords: SARS-CoV-2, virus variants, vaccine, boost, neutralizing effects, primates
Summary of Study: This study showed that a third vaccination administered as a booster, regardless of composition, to the currently approved two dose regimens could effectively promote broadly neutralizing antibodies against all variants of concern.
References: PMID: 35101265 / doi: 10.1016/j.vaccine.2022.01.021
Contact Info: Natalie Anosova: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22000457?via%3Dihub=
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Emergent BioSolutions; Yoh Services LLC; Sanofi Pasteur; Translate Bio; UT Health Science Center at Houston
Keywords: SARS-CoV-2, virus variants, vaccine, boost, neutralizing effects, primates
Summary of Study: This study showed that a third vaccination administered as a booster, regardless of composition, to the currently approved two dose regimens could effectively promote broadly neutralizing antibodies against all variants of concern.
References: PMID: 35101265 / doi: 10.1016/j.vaccine.2022.01.021
Contact Info: Natalie Anosova: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22000457?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; Gilead Sciences
Keywords: SARS-CoV-2, Remdesivir, subcutaneous administration, pathology, virus load, primates
Summary of Study: Early subcutaneous administration of remdesivir can protect from lower respiratory tract disease caused by SARS-CoV-2.
References: PMID: 35032523 / doi: 10.1016/j.antiviral.2022.105246
Contact Info: Emmie de Wit: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0166354222000146?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; Gilead Sciences
Keywords: SARS-CoV-2, Remdesivir, subcutaneous administration, pathology, virus load, primates
Summary of Study: Early subcutaneous administration of remdesivir can protect from lower respiratory tract disease caused by SARS-CoV-2.
References: PMID: 35032523 / doi: 10.1016/j.antiviral.2022.105246
Contact Info: Emmie de Wit: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0166354222000146?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane School of Medicine
Keywords: SARS-CoV-2, monoclonal antibody prophylaxis, virus reproduction, primates
Summary of Study: High viral loads were observed in the intestinal mucosa of a rhesus macaque post challenge with SARS-CoV-2 after prophylactic administration of combination anti-spike antibody therapy. Intrahost evolution of virus was seen, with sequences changing in accordance with enhanced replication capacity, as well as site-specific differences potentially indicating preferential replication.
References: PMID: 35429402 / doi: 10.1093/infdis/jiac134
Contact Info: Chad Roy: [email protected]
URL: https://academic.oup.com/jid/article/226/9/1588/6569365?login=false
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane School of Medicine
Keywords: SARS-CoV-2, monoclonal antibody prophylaxis, virus reproduction, primates
Summary of Study: High viral loads were observed in the intestinal mucosa of a rhesus macaque post challenge with SARS-CoV-2 after prophylactic administration of combination anti-spike antibody therapy. Intrahost evolution of virus was seen, with sequences changing in accordance with enhanced replication capacity, as well as site-specific differences potentially indicating preferential replication.
References: PMID: 35429402 / doi: 10.1093/infdis/jiac134
Contact Info: Chad Roy: [email protected]
URL: https://academic.oup.com/jid/article/226/9/1588/6569365?login=false
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine; Tulane National Primate Research Center
Keywords: SARS-CoV-2, neuropathogenesis, primates
Summary of Study: Substantial pathological changes in brains of SARS-CoV-2 infected NHPs are compatible with autopsy and imaging reports of infected human subjects.
References: PMID: 35365631 / doi: 10.1038/s41467-022-29440-z
Contact Info: Tracy Fischer: [email protected]
URL: https://www.nature.com/articles/s41467-022-29440-z
NHP Species: african green monkeys, rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine; Tulane National Primate Research Center
Keywords: SARS-CoV-2, neuropathogenesis, primates
Summary of Study: Substantial pathological changes in brains of SARS-CoV-2 infected NHPs are compatible with autopsy and imaging reports of infected human subjects.
References: PMID: 35365631 / doi: 10.1038/s41467-022-29440-z
Contact Info: Tracy Fischer: [email protected]
URL: https://www.nature.com/articles/s41467-022-29440-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Tufts University Cummings School of Veterinary Medicine; Vaccine & Gene Therapy Institute/OHSU; University of Montreal; Oregon National Primate Research Center; Ragon Institute of MGH, MIT, and Harvard
Keywords: SARS-CoV-2, Ad26.COV2.S vaccine, transcriptional and proteomic profiling, primates
Summary of Study: Study showed that vaccination with Ad26.COV2.S protected hamsters and rhesus macaques challenged with SARS-CoV-2 from developing excessive proinflammatory responses mediated by IL-6 and IL-1, macrophages, and neutrophil activation.
References: PMID: 35395058 / doi: 10.1371/journal.ppat.1009990
Contact Info: Dan Barouch: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009990
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Tufts University Cummings School of Veterinary Medicine; Vaccine & Gene Therapy Institute/OHSU; University of Montreal; Oregon National Primate Research Center; Ragon Institute of MGH, MIT, and Harvard
Keywords: SARS-CoV-2, Ad26.COV2.S vaccine, transcriptional and proteomic profiling, primates
Summary of Study: Study showed that vaccination with Ad26.COV2.S protected hamsters and rhesus macaques challenged with SARS-CoV-2 from developing excessive proinflammatory responses mediated by IL-6 and IL-1, macrophages, and neutrophil activation.
References: PMID: 35395058 / doi: 10.1371/journal.ppat.1009990
Contact Info: Dan Barouch: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009990
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Fred Hutchinson Cancer Research Center; Department of Medicine, University of Washington
Keywords: SARS-CoV-2, remdesivir, math modeling, antiviral potency, nasal passages, lungs, primates
Summary of Study: In rhesus macaques, the nonlinear forces governing SARS-CoV-2 viral load trajectories in the lung and nasal passages differ substantially in the presence of a partially effective antiviral therapy. To the extent that the rhesus macaque model approximates human infection, nasal viral load remains a promising surrogate endpoint marker but perhaps only in the context of a highly potent antiviral therapy.
References: PMID: 35634576 / doi: 10.1016/j.isci.2022.104448
Contact Info: Joshua Schiffer: [email protected]
URL: https://www.cell.com/iscience/fulltext/S2589-0042(22)00719-2?_returnURL=https%3…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Fred Hutchinson Cancer Research Center; Department of Medicine, University of Washington
Keywords: SARS-CoV-2, remdesivir, math modeling, antiviral potency, nasal passages, lungs, primates
Summary of Study: In rhesus macaques, the nonlinear forces governing SARS-CoV-2 viral load trajectories in the lung and nasal passages differ substantially in the presence of a partially effective antiviral therapy. To the extent that the rhesus macaque model approximates human infection, nasal viral load remains a promising surrogate endpoint marker but perhaps only in the context of a highly potent antiviral therapy.
References: PMID: 35634576 / doi: 10.1016/j.isci.2022.104448
Contact Info: Joshua Schiffer: [email protected]
URL: https://www.cell.com/iscience/fulltext/S2589-0042(22)00719-2?_returnURL=https%3…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Biomedical Primate Research Centre; Consejo Superior de Investigaciones Cientificas (CSIC); Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas (CIBERINFEC); Erasmus Medical Center; Instituto de Investigacion Hospital Universitario 12 de Octubre (imas12); Universidad Complutense School of Medicine, Biofabri
Keywords: SARS-CoV-2, vaccine, modified vaccinia virus Ankara vector, immune response, primates
Summary of Study: The MVA-S vaccine is safe and well tolerated in rhesus macaques, being highly immunogenic with the induction of potent levels of binding and neutralizing antibodies against several SARS-CoV-2 VOC, as well as Th1-skewed cell responses.
References: PMID: 35371043 / doi: 10.3389/fimmu.2022.845887
Contact Info: Petra Mooij: [email protected]; Juan Garcia-Arriaza: [email protected]; Gerrit Koopman: [email protected]; Mariano Esteban: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.845887/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Biomedical Primate Research Centre; Consejo Superior de Investigaciones Cientificas (CSIC); Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas (CIBERINFEC); Erasmus Medical Center; Instituto de Investigacion Hospital Universitario 12 de Octubre (imas12); Universidad Complutense School of Medicine, Biofabri
Keywords: SARS-CoV-2, vaccine, modified vaccinia virus Ankara vector, immune response, primates
Summary of Study: The MVA-S vaccine is safe and well tolerated in rhesus macaques, being highly immunogenic with the induction of potent levels of binding and neutralizing antibodies against several SARS-CoV-2 VOC, as well as Th1-skewed cell responses.
References: PMID: 35371043 / doi: 10.3389/fimmu.2022.845887
Contact Info: Petra Mooij: [email protected]; Juan Garcia-Arriaza: [email protected]; Gerrit Koopman: [email protected]; Mariano Esteban: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.845887/full
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Guangzhou Medical University; Macau University of Science and Technology; St. Januario Central Hospital Macau
Keywords: SARS-CoV-2, homologous or heterogenous vaccination boosters, virus variants, primates
Summary of Study: The Omicron BA.1 variant showed little sensitivity to all of the neutralizing antibodies evaluated in this study, adding to the emerging body of evidence that the resistance to neutralizing antibodies is conferred largely by the mutations in the RBD, since pseudovirus harboring additional spike protein mutations did not significantly change the resistance to neutralizing activity. A recombinant RBD protein vaccine may be a promising approach for future vaccine development.
References: PMID: 35592756 / doi: 10.1002/mco2.143
Contact Info: Kang Zhang: [email protected]; Gen Li: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095991/
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Guangzhou Medical University; Macau University of Science and Technology; St. Januario Central Hospital Macau
Keywords: SARS-CoV-2, homologous or heterogenous vaccination boosters, virus variants, primates
Summary of Study: The Omicron BA.1 variant showed little sensitivity to all of the neutralizing antibodies evaluated in this study, adding to the emerging body of evidence that the resistance to neutralizing antibodies is conferred largely by the mutations in the RBD, since pseudovirus harboring additional spike protein mutations did not significantly change the resistance to neutralizing activity. A recombinant RBD protein vaccine may be a promising approach for future vaccine development.
References: PMID: 35592756 / doi: 10.1002/mco2.143
Contact Info: Kang Zhang: [email protected]; Gen Li: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095991/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, proteomic and phosphoproteomic profiling, lung and liver pathology, primates
Summary of Study: Proteomic and phosphoproteomic profiling of SARS-CoV-2-infected lung and liver tissues showed potentially active protein synthesis and processing, and dysregulated ECM, cell-to-cell junction, and cytoskeleton but no fibrosis in both the infected lung and liver.
References: PMID: 35091530 / doi: 10.1038/s41392-022-00882-7
Contact Info: Shaui-Yao Lu: [email protected]
URL: https://www.nature.com/articles/s41392-022-00882-7
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, proteomic and phosphoproteomic profiling, lung and liver pathology, primates
Summary of Study: Proteomic and phosphoproteomic profiling of SARS-CoV-2-infected lung and liver tissues showed potentially active protein synthesis and processing, and dysregulated ECM, cell-to-cell junction, and cytoskeleton but no fibrosis in both the infected lung and liver.
References: PMID: 35091530 / doi: 10.1038/s41392-022-00882-7
Contact Info: Shaui-Yao Lu: [email protected]
URL: https://www.nature.com/articles/s41392-022-00882-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center, Texas Biomedical Research Institute; Washington University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, longitudinal scRNAseq, bronchoalveolar lavage, immune response, primates
Summary of Study: Results unequivocally show that in protected, immunocompetent hosts, SARS-CoV-2 infection is characterized by an acute inflammatory response leading to a myeloid cell influx into the lung compartment. Induction of a robust IFN response in macrophages strongly correlates with viremia and subsequent clearance of SARS-CoV-2 from the airways of macaques.
References: PMID: 35115549 / doi: 10.1038/s41467-022-28315-7
Contact Info: Maxim Artyomov: [email protected]
URL: https://www.nature.com/articles/s41467-022-28315-7
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center, Texas Biomedical Research Institute; Washington University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, longitudinal scRNAseq, bronchoalveolar lavage, immune response, primates
Summary of Study: Results unequivocally show that in protected, immunocompetent hosts, SARS-CoV-2 infection is characterized by an acute inflammatory response leading to a myeloid cell influx into the lung compartment. Induction of a robust IFN response in macrophages strongly correlates with viremia and subsequent clearance of SARS-CoV-2 from the airways of macaques.
References: PMID: 35115549 / doi: 10.1038/s41467-022-28315-7
Contact Info: Maxim Artyomov: [email protected]
URL: https://www.nature.com/articles/s41467-022-28315-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Inovio Pharmaceuticals; The Wistar Institute
Keywords: SARS-CoV-2, DNA vaccine, prime-boost vaccination, immune response, primates
Summary of Study: Illustrates the durability of immunity following vaccination with synthetic DNA vaccine encoding the wild-type Spike protein, INO-4800, and additionally supports the use of either INO-4800 or INO-4802 in prime-boost regimens.
References: PMID: 35428500 / doi: 10.1016/j.vaccine.2022.03.060
Contact Info: Kate Broderick: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22003681?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Inovio Pharmaceuticals; The Wistar Institute
Keywords: SARS-CoV-2, DNA vaccine, prime-boost vaccination, immune response, primates
Summary of Study: Illustrates the durability of immunity following vaccination with synthetic DNA vaccine encoding the wild-type Spike protein, INO-4800, and additionally supports the use of either INO-4800 or INO-4802 in prime-boost regimens.
References: PMID: 35428500 / doi: 10.1016/j.vaccine.2022.03.060
Contact Info: Kate Broderick: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22003681?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center, Texas Biomedical Research Institute; Washington University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, longitudinal scRNAseq, bronchoalveolar lavage, immune response, primates
Summary of Study: Results unequivocally show that in protected, immunocompetent hosts, SARS-CoV-2 infection is characterized by an acute inflammatory response leading to a myeloid cell influx into the lung compartment. Induction of a robust IFN response in macrophages strongly correlates with viremia and subsequent clearance of SARS-CoV-2 from the airways of macaques.
References: PMID: 35115549 / doi: 10.1038/s41467-022-28315-7
Contact Info: Maxim Artyomov: [email protected]
URL: https://www.nature.com/articles/s41467-022-28315-7
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center, Texas Biomedical Research Institute; Washington University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, longitudinal scRNAseq, bronchoalveolar lavage, immune response, primates
Summary of Study: Results unequivocally show that in protected, immunocompetent hosts, SARS-CoV-2 infection is characterized by an acute inflammatory response leading to a myeloid cell influx into the lung compartment. Induction of a robust IFN response in macrophages strongly correlates with viremia and subsequent clearance of SARS-CoV-2 from the airways of macaques.
References: PMID: 35115549 / doi: 10.1038/s41467-022-28315-7
Contact Info: Maxim Artyomov: [email protected]
URL: https://www.nature.com/articles/s41467-022-28315-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Henry M. Jackson Foundation for the Advancement of Military Medicine; Washington University; NCI/NIH; Bioqual; Oak Ridge Institute of Science and Education; Columbia University Vagelos College of Physicians and Surgeons; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, nanoparticle vaccine, cellular and humoral immune responses, primates
Summary of Study: Nonhuman primates vaccinated with two doses of SpFN (a SARS-CoV-2 spike protein ferritin nanoparticle vaccine) were protected against SARS-CoV-2 challenge. SErum isolated from vaccinated animals neutralized several variants of concern, including the delta variant.
References: PMID: 39414540 / doi: 10.1126/scitranslmed.abi5735
Contact Info: M. Gordon Joyce: [email protected]; Kayvon Modjarrad: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abi5735
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Henry M. Jackson Foundation for the Advancement of Military Medicine; Washington University; NCI/NIH; Bioqual; Oak Ridge Institute of Science and Education; Columbia University Vagelos College of Physicians and Surgeons; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, nanoparticle vaccine, cellular and humoral immune responses, primates
Summary of Study: Nonhuman primates vaccinated with two doses of SpFN (a SARS-CoV-2 spike protein ferritin nanoparticle vaccine) were protected against SARS-CoV-2 challenge. SErum isolated from vaccinated animals neutralized several variants of concern, including the delta variant.
References: PMID: 39414540 / doi: 10.1126/scitranslmed.abi5735
Contact Info: M. Gordon Joyce: [email protected]; Kayvon Modjarrad: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abi5735
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; University of Oxford
Keywords: SARS-CoV-2, age-specific immune responses, viral load, primates
Summary of Study: Despite similar disease outcomes, multiomics profiling suggests that age may delay or impair antiviral cellular immune responses and delay efficient return to homeostasis.
References: PMID: 35039442 / doi: 10.26508/lsa.202101314
Contact Info: Emmie de Wit: [email protected]
URL: https://www.life-science-alliance.org/content/5/4/e202101314
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; University of Oxford
Keywords: SARS-CoV-2, age-specific immune responses, viral load, primates
Summary of Study: Despite similar disease outcomes, multiomics profiling suggests that age may delay or impair antiviral cellular immune responses and delay efficient return to homeostasis.
References: PMID: 35039442 / doi: 10.26508/lsa.202101314
Contact Info: Emmie de Wit: [email protected]
URL: https://www.life-science-alliance.org/content/5/4/e202101314
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Paris-East Creteil University; Universite Paris-Saclay Fontenay-aux-Roses; CEA-INSERM, University of Lille; Universite de Lyon; Centre de Recherche en Cancerologie de Lyon; Institut Curie; Justus Liebig University
Keywords: SARS-CoV-2, lung cell senescence, RNA analysis, pathology, humans, primates
Summary of Study: Cell senescence was monitored in cynomolgus macaques to evaluate potential links between SARS-CoV-2 infection and aging. Data constitute the first evidence of temporal and topographic relations between senescent cell accumulation and pulmonary lesions induced by SARS-CoV-2.
References: PMID: 34648725 / doi: 10.1165/rcmb.2021-0205LE
Contact Info: Serge Adnot: [email protected]
URL: https://www.atsjournals.org/doi/10.1165/rcmb.2021-0205LE?url_ver=Z39.88-2003&rf…
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Paris-East Creteil University; Universite Paris-Saclay Fontenay-aux-Roses; CEA-INSERM, University of Lille; Universite de Lyon; Centre de Recherche en Cancerologie de Lyon; Institut Curie; Justus Liebig University
Keywords: SARS-CoV-2, lung cell senescence, RNA analysis, pathology, humans, primates
Summary of Study: Cell senescence was monitored in cynomolgus macaques to evaluate potential links between SARS-CoV-2 infection and aging. Data constitute the first evidence of temporal and topographic relations between senescent cell accumulation and pulmonary lesions induced by SARS-CoV-2.
References: PMID: 34648725 / doi: 10.1165/rcmb.2021-0205LE
Contact Info: Serge Adnot: [email protected]
URL: https://www.atsjournals.org/doi/10.1165/rcmb.2021-0205LE?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Shanghai Jiao Tong University; Westlake University, Hangzhou; University of Texas; Jecho Biopharmaceuticals; Jecho Laboratories; Zhengzhou University People's Hospital
Keywords: SARS-CoV-2, virus variants, neutralizing monoclonal antibodies, immune response, mice, primates
Summary of Study: An antibody designated as 2G1 efficiently neutralized all VOCs including widely spread Alpha, Beta, Gamma, Delta variants and Cluster 5, a variant with Y453F substitution that once caused public concern due to its zoonotic characteristics.
References: PMID: 35169121 / doi: 10.1038/s41421-022-00381-7
Contact Info: Lei Han: [email protected]
URL: https://www.nature.com/articles/s41421-022-00381-7
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Shanghai Jiao Tong University; Westlake University, Hangzhou; University of Texas; Jecho Biopharmaceuticals; Jecho Laboratories; Zhengzhou University People's Hospital
Keywords: SARS-CoV-2, virus variants, neutralizing monoclonal antibodies, immune response, mice, primates
Summary of Study: An antibody designated as 2G1 efficiently neutralized all VOCs including widely spread Alpha, Beta, Gamma, Delta variants and Cluster 5, a variant with Y453F substitution that once caused public concern due to its zoonotic characteristics.
References: PMID: 35169121 / doi: 10.1038/s41421-022-00381-7
Contact Info: Lei Han: [email protected]
URL: https://www.nature.com/articles/s41421-022-00381-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Fudan University; The University of Hong Kong; Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park; Graduate School of Peking Union Medical College; National Institute for Food and Drug Control, Beijing, China; Fulgent Pharma LLC
Keywords: SARS-CoV-2, pan-sarbecovirus vaccine, immune response, virus variants, primates
Summary of Study: A pan-sarbecovirus vaccine consisting of human IgG Fc fragment-conjugated RBC of the original SARS-CoV-2 WA1 strain as the immunogen and a novel small-molecule non-nucleotide STING agonist as the adjuvant could be used to prevent infection by the current SARS-CoV-2 variants, including Omicron, and future emerging sarbecoviruses.
References: PMID: 35210607 / doi: 10. 1038/s41422-022-00631-z
Contact Info: Youchun Wang: [email protected]
URL: https://www.nature.com/articles/s41422-022-00631-z
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Fudan University; The University of Hong Kong; Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park; Graduate School of Peking Union Medical College; National Institute for Food and Drug Control, Beijing, China; Fulgent Pharma LLC
Keywords: SARS-CoV-2, pan-sarbecovirus vaccine, immune response, virus variants, primates
Summary of Study: A pan-sarbecovirus vaccine consisting of human IgG Fc fragment-conjugated RBC of the original SARS-CoV-2 WA1 strain as the immunogen and a novel small-molecule non-nucleotide STING agonist as the adjuvant could be used to prevent infection by the current SARS-CoV-2 variants, including Omicron, and future emerging sarbecoviruses.
References: PMID: 35210607 / doi: 10. 1038/s41422-022-00631-z
Contact Info: Youchun Wang: [email protected]
URL: https://www.nature.com/articles/s41422-022-00631-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medicine Sciences & Peking Union Medical College; National Institute for Viral Disease Control and Prevention
Keywords: SARS-CoV-2, heterologous vaccines, intradermal administration, immune response, primates
Summary of Study: This study reports a new heterologous prime-boost strategy of intradermal immunization with the inactivated vaccine and K-S antigen. This strategy can significantly increase the neutralizing antibody titers and promote specific T cell responses in mice and macaques.
References: PMID: 34931939 / doi: 10.1080/22221751.2021807https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
Contact Info: Wenbo Xu: [email protected]; Qihan Li: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medicine Sciences & Peking Union Medical College; National Institute for Viral Disease Control and Prevention
Keywords: SARS-CoV-2, heterologous vaccines, intradermal administration, immune response, primates
Summary of Study: This study reports a new heterologous prime-boost strategy of intradermal immunization with the inactivated vaccine and K-S antigen. This strategy can significantly increase the neutralizing antibody titers and promote specific T cell responses in mice and macaques.
References: PMID: 34931939 / doi: 10.1080/22221751.2021807https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
Contact Info: Wenbo Xu: [email protected]; Qihan Li: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shanghai Medical College, Fudan University; Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College; the First Affiliated Hospital of Guangzhou Medical University; Guangzhou Eighth People's Hospital of Guangzhou Medical University; Bio-Island; Graduate School of Peking Union Medical College; NIFDC; Fulgent Pharma LLC
Keywords: SARS-CoV-2, pan-sarbecovirus vaccines, STING agonist CF501, virus variants, immune response, mice, rabbits, primates.
Summary of Study: A pan-sarbecovirus vaccine was designed by using human IgG Fc-conjugated RBD from the original SARS-CoV-2 strain as the vaccine's immunogen and the STING agonist CF501 as the vaccine's adjuvant. This CF501/RBD-Fc vaccine candidate was able to induce extremely potent, durable, and broad-spectrum nAb and T cell responses, as well as protective immunity, suggesting its potential for development as a highly potent and durable pan-sarbecovirus vaccine.
References: PMID: 35046518 / doi: 10.1038/s41422-022-00612-2
Contact Info: Youchun Wang: [email protected]; Yilong Zhang: [email protected]; Jincun Zhao: [email protected]
URL: https://www.nature.com/articles/s41422-022-00612-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shanghai Medical College, Fudan University; Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College; the First Affiliated Hospital of Guangzhou Medical University; Guangzhou Eighth People's Hospital of Guangzhou Medical University; Bio-Island; Graduate School of Peking Union Medical College; NIFDC; Fulgent Pharma LLC
Keywords: SARS-CoV-2, pan-sarbecovirus vaccines, STING agonist CF501, virus variants, immune response, mice, rabbits, primates.
Summary of Study: A pan-sarbecovirus vaccine was designed by using human IgG Fc-conjugated RBD from the original SARS-CoV-2 strain as the vaccine's immunogen and the STING agonist CF501 as the vaccine's adjuvant. This CF501/RBD-Fc vaccine candidate was able to induce extremely potent, durable, and broad-spectrum nAb and T cell responses, as well as protective immunity, suggesting its potential for development as a highly potent and durable pan-sarbecovirus vaccine.
References: PMID: 35046518 / doi: 10.1038/s41422-022-00612-2
Contact Info: Youchun Wang: [email protected]; Yilong Zhang: [email protected]; Jincun Zhao: [email protected]
URL: https://www.nature.com/articles/s41422-022-00612-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: China Pharmaceutical University; Yunnan Walvax Biotech
Keywords: SARS-CoV-2, chimpanzee adenovirus-based vaccine, immunogenicity, toxicology, rats, primates
Summary of Study: AdC68-19S, a recombinant chimpanzee adenovirus serotype 68 vector-based vaccine encoding the full-length spike protein of SARS-CoV-2, induced an effective immune response with a good safety profile in rhesus macaques.
References: PMID: 35226134 / doi: 10.1007/s00204-021-03221-x
Contact Info: Zhen Huang: [email protected]
URL: https://link.springer.com/article/10.1007/s00204-021-03221-x
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: China Pharmaceutical University; Yunnan Walvax Biotech
Keywords: SARS-CoV-2, chimpanzee adenovirus-based vaccine, immunogenicity, toxicology, rats, primates
Summary of Study: AdC68-19S, a recombinant chimpanzee adenovirus serotype 68 vector-based vaccine encoding the full-length spike protein of SARS-CoV-2, induced an effective immune response with a good safety profile in rhesus macaques.
References: PMID: 35226134 / doi: 10.1007/s00204-021-03221-x
Contact Info: Zhen Huang: [email protected]
URL: https://link.springer.com/article/10.1007/s00204-021-03221-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: City of Hope National Medical Center
Keywords: SARS-CoV-2, synthetic multiantigen modified vaccine, COH04S1, immune response, hamsters, primates
Summary of Study: Vaccine candidate C0H04S1 stimulates protective immunity against SARS-CoV-2 in Syrian hamsters by intramuscular and intranasal vaccination and in non-human primates through two-dose and single-dose regimens.
References: PMID: 35064109 / doi: 10.1038/s41541-022-00436-6
Contact Info: Felix Wussow: [email protected]
URL: https://www.nature.com/articles/s41541-022-00436-6
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: City of Hope National Medical Center
Keywords: SARS-CoV-2, synthetic multiantigen modified vaccine, COH04S1, immune response, hamsters, primates
Summary of Study: Vaccine candidate C0H04S1 stimulates protective immunity against SARS-CoV-2 in Syrian hamsters by intramuscular and intranasal vaccination and in non-human primates through two-dose and single-dose regimens.
References: PMID: 35064109 / doi: 10.1038/s41541-022-00436-6
Contact Info: Felix Wussow: [email protected]
URL: https://www.nature.com/articles/s41541-022-00436-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: SUNY Upstate Medical University; Walter Reed Army Institute of Research; NIAID
Keywords: SARS-CoV-2, mRNA-1273 vaccine, respiratory tract, inflammation, primates
Summary of Study: This study defines the lower respiratory tract cellular and transcriptional signature associated with SARS-CoV-2 in macaques using two distinct viral variants, and identifies conserved signatures of vaccine-elicited protection from infection-attendant inflammation. These date emphasize the contribution of inflammatory/migratory DCs and macrophages to lower respiratory tract inflammation following SARS-CoV-2 infection, and define a critical relationship between antibody titers, post-challenge viral burden, and broad infection-elicited inflammation.
References: PMID: 35653196 / doi: 10.1172/jci.insight.160039
Contact Info: Robert Seder: Robert Seder: [email protected]
URL: https://insight.jci.org/articles/view/160039
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: SUNY Upstate Medical University; Walter Reed Army Institute of Research; NIAID
Keywords: SARS-CoV-2, mRNA-1273 vaccine, respiratory tract, inflammation, primates
Summary of Study: This study defines the lower respiratory tract cellular and transcriptional signature associated with SARS-CoV-2 in macaques using two distinct viral variants, and identifies conserved signatures of vaccine-elicited protection from infection-attendant inflammation. These date emphasize the contribution of inflammatory/migratory DCs and macrophages to lower respiratory tract inflammation following SARS-CoV-2 infection, and define a critical relationship between antibody titers, post-challenge viral burden, and broad infection-elicited inflammation.
References: PMID: 35653196 / doi: 10.1172/jci.insight.160039
Contact Info: Robert Seder: Robert Seder: [email protected]
URL: https://insight.jci.org/articles/view/160039
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Washington; Washington National Primate Research Center; HDT Bio
Keywords: SARS-CoV-2, immunocompromised animals, SIV, RNA vaccine, immunogenicity, primates
Summary of Study: SARS-CoV-2 alphavirus-derived replicon RNA vaccine formulated with a novel Lipid InOrganic Nanoparticle (LION) emulsion (repRNA-CoV2S) induced robust cellular and humoral immune responses after a single immunization in immunocompromised SIV-infected animals as a highly relevant model of untreated HIV infection in humans.
References: PMID: 34992610 / doi: 10.3389/fimmu.2021.800723
Contact Info: Deborah Fuller: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.800723/full
NHP Species: pigtail macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Washington; Washington National Primate Research Center; HDT Bio
Keywords: SARS-CoV-2, immunocompromised animals, SIV, RNA vaccine, immunogenicity, primates
Summary of Study: SARS-CoV-2 alphavirus-derived replicon RNA vaccine formulated with a novel Lipid InOrganic Nanoparticle (LION) emulsion (repRNA-CoV2S) induced robust cellular and humoral immune responses after a single immunization in immunocompromised SIV-infected animals as a highly relevant model of untreated HIV infection in humans.
References: PMID: 34992610 / doi: 10.3389/fimmu.2021.800723
Contact Info: Deborah Fuller: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.800723/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shanghai Medical College, Fudan University; Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College; the First Affiliated Hospital of Guangzhou Medical University; Guangzhou Eighth People's Hospital of Guangzhou Medical University; Bio-Island; Graduate School of Peking Union Medical College; NIFDC; Fulgent Pharma LLC
Keywords: SARS-CoV-2, pan-sarbecovirus vaccines, STING agonist CF501, virus variants, immune response, mice, rabbits, primates.
Summary of Study: A pan-sarbecovirus vaccine was designed by using human IgG Fc-conjugated RBD from the original SARS-CoV-2 strain as the vaccine's immunogen and the STING agonist CF501 as the vaccine's adjuvant. This CF501/RBD-Fc vaccine candidate was able to induce extremely potent, durable, and broad-spectrum nAb and T cell responses, as well as protective immunity, suggesting its potential for development as a highly potent and durable pan-sarbecovirus vaccine.
References: PMID: 35046518 / doi: 10.1038/s41422-022-00612-2
Contact Info: Youchun Wang: [email protected]; Yilong Zhang: [email protected]; Jincun Zhao: [email protected]
URL: https://www.nature.com/articles/s41422-022-00612-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shanghai Medical College, Fudan University; Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College; the First Affiliated Hospital of Guangzhou Medical University; Guangzhou Eighth People's Hospital of Guangzhou Medical University; Bio-Island; Graduate School of Peking Union Medical College; NIFDC; Fulgent Pharma LLC
Keywords: SARS-CoV-2, pan-sarbecovirus vaccines, STING agonist CF501, virus variants, immune response, mice, rabbits, primates.
Summary of Study: A pan-sarbecovirus vaccine was designed by using human IgG Fc-conjugated RBD from the original SARS-CoV-2 strain as the vaccine's immunogen and the STING agonist CF501 as the vaccine's adjuvant. This CF501/RBD-Fc vaccine candidate was able to induce extremely potent, durable, and broad-spectrum nAb and T cell responses, as well as protective immunity, suggesting its potential for development as a highly potent and durable pan-sarbecovirus vaccine.
References: PMID: 35046518 / doi: 10.1038/s41422-022-00612-2
Contact Info: Youchun Wang: [email protected]; Yilong Zhang: [email protected]; Jincun Zhao: [email protected]
URL: https://www.nature.com/articles/s41422-022-00612-2