Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: Gujarat Biotechnology Research Centre (GBRC), India; Kamdhenu University, Gujarat, India; University of California Santa Barbara, Santa Barbara, CA.
Keywords: SARS-CoV-2, surveillance, RT-PCR, several animal species, primates
Summary of Study: Highlights transmission of SARS-CoV-2 infection from human to animals and suggests being watchful for zoonosis.
References: doi: 10.3390/ijerph192114391
Contact Info: Arunkumar Patel: [email protected]
URL: https://www.mdpi.com/1660-4601/19/21/14391
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: Gujarat Biotechnology Research Centre (GBRC), India; Kamdhenu University, Gujarat, India; University of California Santa Barbara, Santa Barbara, CA.
Keywords: SARS-CoV-2, surveillance, RT-PCR, several animal species, primates
Summary of Study: Highlights transmission of SARS-CoV-2 infection from human to animals and suggests being watchful for zoonosis.
References: doi: 10.3390/ijerph192114391
Contact Info: Arunkumar Patel: [email protected]
URL: https://www.mdpi.com/1660-4601/19/21/14391
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane School of Medicine
Keywords: SARS-CoV-2, aerosol or intra-tracheal/intra-nasal infection, viral load, inflammation, primates
Summary of Study: Cellular mechanisms underlying acute respiratory distress syndrome
References: doi: 10.1038/s42003-022-04310-y
Contact Info: Namita Rout: [email protected]
URL: https://www.nature.com/articles/s42003-022-04310-y
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane School of Medicine
Keywords: SARS-CoV-2, aerosol or intra-tracheal/intra-nasal infection, viral load, inflammation, primates
Summary of Study: Cellular mechanisms underlying acute respiratory distress syndrome
References: doi: 10.1038/s42003-022-04310-y
Contact Info: Namita Rout: [email protected]
URL: https://www.nature.com/articles/s42003-022-04310-y
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Emory University; University of Sao Paulo School of Medicine; Butantan Institute; La Jolla Institute for Immunology
Keywords: SARS-CoV-2, DNA vaccine HIVBr18, HLA class II vaccine epitopes, immunity, humans and primates
Summary of Study: Results provide preliminary proof of concept that immunization with a vaccine encoding epitopes with high and redundant coverage of the human population can elicit potent T cell responses to multiple epitopes, across species and MHC barriers.
References: PMID: 34961636 / doi: 10.1016/j.vaccine.2021.11.076
Contact Info: Edecio Cunha-Neto: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21015504?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Emory University; University of Sao Paulo School of Medicine; Butantan Institute; La Jolla Institute for Immunology
Keywords: SARS-CoV-2, DNA vaccine HIVBr18, HLA class II vaccine epitopes, immunity, humans and primates
Summary of Study: Results provide preliminary proof of concept that immunization with a vaccine encoding epitopes with high and redundant coverage of the human population can elicit potent T cell responses to multiple epitopes, across species and MHC barriers.
References: PMID: 34961636 / doi: 10.1016/j.vaccine.2021.11.076
Contact Info: Edecio Cunha-Neto: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21015504?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medicine Sciences & Peking Union Medical College; National Institute for Viral Disease Control and Prevention
Keywords: SARS-CoV-2, heterologous vaccines, intradermal administration, immune response, primates
Summary of Study: This study reports a new heterologous prime-boost strategy of intradermal immunization with the inactivated vaccine and K-S antigen. This strategy can significantly increase the neutralizing antibody titers and promote specific T cell responses in mice and macaques.
References: PMID: 34931939 / doi: 10.1080/22221751.2021807https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
Contact Info: Wenbo Xu: [email protected]; Qihan Li: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medicine Sciences & Peking Union Medical College; National Institute for Viral Disease Control and Prevention
Keywords: SARS-CoV-2, heterologous vaccines, intradermal administration, immune response, primates
Summary of Study: This study reports a new heterologous prime-boost strategy of intradermal immunization with the inactivated vaccine and K-S antigen. This strategy can significantly increase the neutralizing antibody titers and promote specific T cell responses in mice and macaques.
References: PMID: 34931939 / doi: 10.1080/22221751.2021807https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
Contact Info: Wenbo Xu: [email protected]; Qihan Li: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine
Keywords: SARS-CoV-2, virus genome, gut, virus evolution, primates
Summary of Study: Previous reports that an intact furin cleavage site is important for infection in vivo were confirmed in this study. Additionally, three mutations were identified that may represent an adaptation of SARS-CoV2 to African green monkeys or to NHP generally.
References: PMID: 35062281 / doi: 10.3390/v14010077
Contact Info: Nicholas Maness: [email protected]
URL: https://www.mdpi.com/1999-4915/14/1/77
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine
Keywords: SARS-CoV-2, virus genome, gut, virus evolution, primates
Summary of Study: Previous reports that an intact furin cleavage site is important for infection in vivo were confirmed in this study. Additionally, three mutations were identified that may represent an adaptation of SARS-CoV2 to African green monkeys or to NHP generally.
References: PMID: 35062281 / doi: 10.3390/v14010077
Contact Info: Nicholas Maness: [email protected]
URL: https://www.mdpi.com/1999-4915/14/1/77
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Shanghai Jiao Tong University; Westlake University, Hangzhou; University of Texas; Jecho Biopharmaceuticals; Jecho Laboratories; Zhengzhou University People's Hospital
Keywords: SARS-CoV-2, virus variants, neutralizing monoclonal antibodies, immune response, mice, primates
Summary of Study: An antibody designated as 2G1 efficiently neutralized all VOCs including widely spread Alpha, Beta, Gamma, Delta variants and Cluster 5, a variant with Y453F substitution that once caused public concern due to its zoonotic characteristics.
References: PMID: 35169121 / doi: 10.1038/s41421-022-00381-7
Contact Info: Lei Han: [email protected]
URL: https://www.nature.com/articles/s41421-022-00381-7
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Shanghai Jiao Tong University; Westlake University, Hangzhou; University of Texas; Jecho Biopharmaceuticals; Jecho Laboratories; Zhengzhou University People's Hospital
Keywords: SARS-CoV-2, virus variants, neutralizing monoclonal antibodies, immune response, mice, primates
Summary of Study: An antibody designated as 2G1 efficiently neutralized all VOCs including widely spread Alpha, Beta, Gamma, Delta variants and Cluster 5, a variant with Y453F substitution that once caused public concern due to its zoonotic characteristics.
References: PMID: 35169121 / doi: 10.1038/s41421-022-00381-7
Contact Info: Lei Han: [email protected]
URL: https://www.nature.com/articles/s41421-022-00381-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Peking University; Chinese Academy of Medical Sciences and Peking Union Medical College; WHO Collaborating Center for Standardization and Evaluation of Biologicals
Keywords: SARS-CoV-2, circRNA vaccine, neutralizing antibodies, virus variants, primates
Summary of Study: CircRNA/RBD-Omicron vaccine induced effective neutralizing antibodies against the Omicron but not the Delta variant. In contrast, the circRNA/RBD-Delta vaccine protected against both Delta and Omicron or functioned as a booster after two doses of either native- or Delta-specific vaccination, making it a favorable choice against the current variants of concern of SARS-CoV-2.
References: PMID: 35460644 / doi: 10.1016/j.cell.2022.03.044
Contact Info: Wensheng Wei: [email protected]
URL: https://www.cell.com/cell/fulltext/S0092-8674(22)00394-4?_returnURL=https%3A%2F…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Peking University; Chinese Academy of Medical Sciences and Peking Union Medical College; WHO Collaborating Center for Standardization and Evaluation of Biologicals
Keywords: SARS-CoV-2, circRNA vaccine, neutralizing antibodies, virus variants, primates
Summary of Study: CircRNA/RBD-Omicron vaccine induced effective neutralizing antibodies against the Omicron but not the Delta variant. In contrast, the circRNA/RBD-Delta vaccine protected against both Delta and Omicron or functioned as a booster after two doses of either native- or Delta-specific vaccination, making it a favorable choice against the current variants of concern of SARS-CoV-2.
References: PMID: 35460644 / doi: 10.1016/j.cell.2022.03.044
Contact Info: Wensheng Wei: [email protected]
URL: https://www.cell.com/cell/fulltext/S0092-8674(22)00394-4?_returnURL=https%3A%2F…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: SUNY Upstate Medical University; Walter Reed Army Institute of Research; NIAID
Keywords: SARS-CoV-2, mRNA-1273 vaccine, respiratory tract, inflammation, primates
Summary of Study: This study defines the lower respiratory tract cellular and transcriptional signature associated with SARS-CoV-2 in macaques using two distinct viral variants, and identifies conserved signatures of vaccine-elicited protection from infection-attendant inflammation. These date emphasize the contribution of inflammatory/migratory DCs and macrophages to lower respiratory tract inflammation following SARS-CoV-2 infection, and define a critical relationship between antibody titers, post-challenge viral burden, and broad infection-elicited inflammation.
References: PMID: 35653196 / doi: 10.1172/jci.insight.160039
Contact Info: Robert Seder: Robert Seder: [email protected]
URL: https://insight.jci.org/articles/view/160039
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: SUNY Upstate Medical University; Walter Reed Army Institute of Research; NIAID
Keywords: SARS-CoV-2, mRNA-1273 vaccine, respiratory tract, inflammation, primates
Summary of Study: This study defines the lower respiratory tract cellular and transcriptional signature associated with SARS-CoV-2 in macaques using two distinct viral variants, and identifies conserved signatures of vaccine-elicited protection from infection-attendant inflammation. These date emphasize the contribution of inflammatory/migratory DCs and macrophages to lower respiratory tract inflammation following SARS-CoV-2 infection, and define a critical relationship between antibody titers, post-challenge viral burden, and broad infection-elicited inflammation.
References: PMID: 35653196 / doi: 10.1172/jci.insight.160039
Contact Info: Robert Seder: Robert Seder: [email protected]
URL: https://insight.jci.org/articles/view/160039
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: CAS Key Laboratory of Computational Biology; Shanghai Institute of Nutrition and Health; University of Chinese Academy of Sciences; Chinese Academy of Sciences; Max Planck Institute of Psychiatry, Proteomics and Biomarkers
Keywords: SARS-CoV-2, circadian gene networks, transcriptome, primates
Summary of Study: Many mammalian genes are controlled by a central clock under circadian control, resulting in a rhythmic expression of genes involved in homeostasis. SARS-CoV-2 related genes are also rhythmically expressed, suggesting close interactions with circadian regulators.
References: PMID: 35906476 / doi: 10.1038/s42003-022-03722-0
Contact Info: Guang-Zhong Wang: [email protected]
URL: https://www.nature.com/articles/s42003-022-03722-0
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: CAS Key Laboratory of Computational Biology; Shanghai Institute of Nutrition and Health; University of Chinese Academy of Sciences; Chinese Academy of Sciences; Max Planck Institute of Psychiatry, Proteomics and Biomarkers
Keywords: SARS-CoV-2, circadian gene networks, transcriptome, primates
Summary of Study: Many mammalian genes are controlled by a central clock under circadian control, resulting in a rhythmic expression of genes involved in homeostasis. SARS-CoV-2 related genes are also rhythmically expressed, suggesting close interactions with circadian regulators.
References: PMID: 35906476 / doi: 10.1038/s42003-022-03722-0
Contact Info: Guang-Zhong Wang: [email protected]
URL: https://www.nature.com/articles/s42003-022-03722-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Institutes for Food and Drug Control, Beijing; Guangzhou Laboratory; Kunming National High-level Biosafety Primate Research Center
Keywords: SARS-CoV-2, vaccine, chimpanzee adenovirus vector, immune response, mice, primates
Summary of Study: Using a chimpanzee adenovirus vectored vaccine expressing SARS-CoV2 spike in combination with an inactivated vaccine reduced lung injury risk while maintaining flexibility of the antibody regulation system.
References: PMID: 36059554 / doi: 10.3389/fimmu.2022.949248
Contact Info: Junzhi Wang: [email protected]; Zhenglun Liang: [email protected]; Miao Xu: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.949248/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Institutes for Food and Drug Control, Beijing; Guangzhou Laboratory; Kunming National High-level Biosafety Primate Research Center
Keywords: SARS-CoV-2, vaccine, chimpanzee adenovirus vector, immune response, mice, primates
Summary of Study: Using a chimpanzee adenovirus vectored vaccine expressing SARS-CoV2 spike in combination with an inactivated vaccine reduced lung injury risk while maintaining flexibility of the antibody regulation system.
References: PMID: 36059554 / doi: 10.3389/fimmu.2022.949248
Contact Info: Junzhi Wang: [email protected]; Zhenglun Liang: [email protected]; Miao Xu: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.949248/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane University, Memorial Sloan Kettering Cancer Ctr, Weill Cornell Medical College, Instuto de Química Pontificia Universidad Católica de Valparaíso
Keywords: SARS-CoV-2, urokinase plasminogen activator receptor, renal dysfunction, pathology, primates
Summary of Study: Elevated soluble urokinase plasminogen activator receptor
References: doi: 10.1111/jmp.12626
Contact Info: Minolfa Prieto: [email protected]
URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/jmp.12626
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane University, Memorial Sloan Kettering Cancer Ctr, Weill Cornell Medical College, Instuto de Química Pontificia Universidad Católica de Valparaíso
Keywords: SARS-CoV-2, urokinase plasminogen activator receptor, renal dysfunction, pathology, primates
Summary of Study: Elevated soluble urokinase plasminogen activator receptor
References: doi: 10.1111/jmp.12626
Contact Info: Minolfa Prieto: [email protected]
URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/jmp.12626
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; Gilead Sciences
Keywords: SARS-CoV-2, Remdesivir, subcutaneous administration, pathology, virus load, primates
Summary of Study: Early subcutaneous administration of remdesivir can protect from lower respiratory tract disease caused by SARS-CoV-2.
References: PMID: 35032523 / doi: 10.1016/j.antiviral.2022.105246
Contact Info: Emmie de Wit: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0166354222000146?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; Gilead Sciences
Keywords: SARS-CoV-2, Remdesivir, subcutaneous administration, pathology, virus load, primates
Summary of Study: Early subcutaneous administration of remdesivir can protect from lower respiratory tract disease caused by SARS-CoV-2.
References: PMID: 35032523 / doi: 10.1016/j.antiviral.2022.105246
Contact Info: Emmie de Wit: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0166354222000146?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Janssen Vaccines and Prevention; Ragon Institute of MGH, MIT and Harvard; BIOQUAL; Amsterdam University Medical Center
Keywords: SARS-CoV-2, homologous or variant booster vaccine, humoral and cellular immune responses, primates
Summary of Study: A late boost with Ad26.COV2.S or Ad26.COV2.S.351 resulted in a marked increase in humoral and cellular immune responses that were highly cross-reactive across multiple SARS-CoV-2 variants in rhesus macaques.
References: PMID: 35191769 / doi: 10.1126/scitranslmed.bm4996
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abm4996?rfr_dat=cr_pub++0…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Janssen Vaccines and Prevention; Ragon Institute of MGH, MIT and Harvard; BIOQUAL; Amsterdam University Medical Center
Keywords: SARS-CoV-2, homologous or variant booster vaccine, humoral and cellular immune responses, primates
Summary of Study: A late boost with Ad26.COV2.S or Ad26.COV2.S.351 resulted in a marked increase in humoral and cellular immune responses that were highly cross-reactive across multiple SARS-CoV-2 variants in rhesus macaques.
References: PMID: 35191769 / doi: 10.1126/scitranslmed.bm4996
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abm4996?rfr_dat=cr_pub++0…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre; Department of Pathology, Amsterdam UMC; Utrecht University; Leiden University Medical Center; University of Twente
Keywords: SARS-CoV-2, neuropathology, immune response, primates
Summary of Study: Data highlight the potential of SARS-CoV-2 to cause pathology in the brain of macaques. A range of neurological abnormalities were observed, including hypermetabolic pituitary gland, alpha-synuclein inclusions, activated microglia in the brain parenchyma, and infiltrating T-cells.
References: PMID: 35458506 / doi: 10.3390/v14040776
Contact Info: Ernst Verschoor: [email protected]
URL: https://www.mdpi.com/1999-4915/14/4/776
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre; Department of Pathology, Amsterdam UMC; Utrecht University; Leiden University Medical Center; University of Twente
Keywords: SARS-CoV-2, neuropathology, immune response, primates
Summary of Study: Data highlight the potential of SARS-CoV-2 to cause pathology in the brain of macaques. A range of neurological abnormalities were observed, including hypermetabolic pituitary gland, alpha-synuclein inclusions, activated microglia in the brain parenchyma, and infiltrating T-cells.
References: PMID: 35458506 / doi: 10.3390/v14040776
Contact Info: Ernst Verschoor: [email protected]
URL: https://www.mdpi.com/1999-4915/14/4/776
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Universite Paris-Saclay, INSERM, CEA; Life and Soft; IRCCS Ospedale San Raffaele; Institut Pasteur
Keywords: SARS-CoV-2, neonate animals, immune response, pathology, primates
Summary of Study: This pilot study demonstrates that neonatal NHPs are a relevant model for pediatric SARS-CoV-2 infection.
References: PMID: 35603150 / doi: 10.3389/fimmu.2022.855230
Contact Info: Nabila Seddiki: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.855230/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Universite Paris-Saclay, INSERM, CEA; Life and Soft; IRCCS Ospedale San Raffaele; Institut Pasteur
Keywords: SARS-CoV-2, neonate animals, immune response, pathology, primates
Summary of Study: This pilot study demonstrates that neonatal NHPs are a relevant model for pediatric SARS-CoV-2 infection.
References: PMID: 35603150 / doi: 10.3389/fimmu.2022.855230
Contact Info: Nabila Seddiki: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.855230/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Tulane University School of Medicine; Beijing Forestry University; Beijing Institute of Lifeomics; Ochsner Clinic Foundation; University of Texas Southwestern Medical Center; Tulane National Primate Research Center
Keywords: SARS-CoV-2, peptide microarrays, neutralizing antibodies, vaccine, primates
Summary of Study: Linear peptide epitopes detected by immunoglobulins after infection have been localized to functionally important virus regions, which can be used to inform vaccine evaluation and targets for site-specific therapy.
References: PMID: 35928300 / doi: 10.34133/2022/9769803
Contact Info: Xiaobo Yu: [email protected]; Tony Hu: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297724/
NHP Species: african green monkeys, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Tulane University School of Medicine; Beijing Forestry University; Beijing Institute of Lifeomics; Ochsner Clinic Foundation; University of Texas Southwestern Medical Center; Tulane National Primate Research Center
Keywords: SARS-CoV-2, peptide microarrays, neutralizing antibodies, vaccine, primates
Summary of Study: Linear peptide epitopes detected by immunoglobulins after infection have been localized to functionally important virus regions, which can be used to inform vaccine evaluation and targets for site-specific therapy.
References: PMID: 35928300 / doi: 10.34133/2022/9769803
Contact Info: Xiaobo Yu: [email protected]; Tony Hu: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297724/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Betuvax LLC; Lomonosov Moscow State University; Clinical Excellence Group LLC; I.I. Mechnikov North-Western State Medical University; PJSC Human Stem Cells Institute; Center of Genetics and Reproductive Medicine; Sechenov First Moscow State Medical University; Biotechnology Developments LLC; Ministry of Health of the Russian Federation
Keywords: SARS-CoV-2, subunit vaccine, “Betuvax-CoV-2”, preclinical studies, several animal species, primates
Summary of Study: A vaccine developed as a subunit that contains a recombinant receptor-binding domain fusion protein and virus-like nanoparticles demonstrates effective protection through COVID-19 neutralizing antibody production and conferring infection and lung damage protection.
References: PMID: 36016181 / doi: 10.3390/vaccines10081290
Contact Info: Anna Vakrusheva: [email protected]
URL: https://www.mdpi.com/2076-393X/10/8/1290
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Betuvax LLC; Lomonosov Moscow State University; Clinical Excellence Group LLC; I.I. Mechnikov North-Western State Medical University; PJSC Human Stem Cells Institute; Center of Genetics and Reproductive Medicine; Sechenov First Moscow State Medical University; Biotechnology Developments LLC; Ministry of Health of the Russian Federation
Keywords: SARS-CoV-2, subunit vaccine, “Betuvax-CoV-2”, preclinical studies, several animal species, primates
Summary of Study: A vaccine developed as a subunit that contains a recombinant receptor-binding domain fusion protein and virus-like nanoparticles demonstrates effective protection through COVID-19 neutralizing antibody production and conferring infection and lung damage protection.
References: PMID: 36016181 / doi: 10.3390/vaccines10081290
Contact Info: Anna Vakrusheva: [email protected]
URL: https://www.mdpi.com/2076-393X/10/8/1290
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Wuhan Institute of Virology; Chinese Academy of Science; Wuhan National Biosafety Library, others
Keywords: SARS-CoV-2, testicular pathological damage, inflammation, primates
Summary of Study: SARS-CoV-2 infection induces testicular injury in Rhesus macaque
References: 10.1016/j.virs.2022.10.008
Contact Info: Z. Wuan: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1995820X22001833?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Wuhan Institute of Virology; Chinese Academy of Science; Wuhan National Biosafety Library, others
Keywords: SARS-CoV-2, testicular pathological damage, inflammation, primates
Summary of Study: SARS-CoV-2 infection induces testicular injury in Rhesus macaque
References: 10.1016/j.virs.2022.10.008
Contact Info: Z. Wuan: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1995820X22001833?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Praesidium Bioscience, Inc., New York, NY; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Intima Bioscience, Inc., New York, NY; Ragon Institute of Massachusetts General Hospital, Massac
Keywords: SARS-CoV-2, CRISPR, stem cell, iPSC, vaccine, universal cell, primates
Summary of Study: A genetically engineered, stem-cell-derived cellular vaccine
References: doi: 10.1016/j.xcrm.2022.100843
Contact Info: Tom Henley: [email protected]; Dan H. Barouch: dbarouch@[email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379122004074?via%3Dihub
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Praesidium Bioscience, Inc., New York, NY; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Intima Bioscience, Inc., New York, NY; Ragon Institute of Massachusetts General Hospital, Massac
Keywords: SARS-CoV-2, CRISPR, stem cell, iPSC, vaccine, universal cell, primates
Summary of Study: A genetically engineered, stem-cell-derived cellular vaccine
References: doi: 10.1016/j.xcrm.2022.100843
Contact Info: Tom Henley: [email protected]; Dan H. Barouch: dbarouch@[email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379122004074?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; Yerkes National Primate Research Center; Emory University School of Medicine; Bioqual; Moderna, Inc.
Keywords: SARS-CoV-2, mRNA-1273 vaccination, longitudinal study, immune response, primates
Summary of Study: While mRNA-1273 provided durable protection against B.1.617.2 challenge, control of the virus was briefly delayed in the lungs and limited in the nose, which may provide the virus with a greater opportunity for transmission.
References: PMID: 34921774 / doi: 10.1016/j.cell.2021.12.002
Contact Info: Robert Seder: [email protected]; Daniel Douek: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0092867421014057?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; Yerkes National Primate Research Center; Emory University School of Medicine; Bioqual; Moderna, Inc.
Keywords: SARS-CoV-2, mRNA-1273 vaccination, longitudinal study, immune response, primates
Summary of Study: While mRNA-1273 provided durable protection against B.1.617.2 challenge, control of the virus was briefly delayed in the lungs and limited in the nose, which may provide the virus with a greater opportunity for transmission.
References: PMID: 34921774 / doi: 10.1016/j.cell.2021.12.002
Contact Info: Robert Seder: [email protected]; Daniel Douek: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0092867421014057?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; University of Oxford
Keywords: SARS-CoV-2, age-specific immune responses, viral load, primates
Summary of Study: Despite similar disease outcomes, multiomics profiling suggests that age may delay or impair antiviral cellular immune responses and delay efficient return to homeostasis.
References: PMID: 35039442 / doi: 10.26508/lsa.202101314
Contact Info: Emmie de Wit: [email protected]
URL: https://www.life-science-alliance.org/content/5/4/e202101314
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; University of Oxford
Keywords: SARS-CoV-2, age-specific immune responses, viral load, primates
Summary of Study: Despite similar disease outcomes, multiomics profiling suggests that age may delay or impair antiviral cellular immune responses and delay efficient return to homeostasis.
References: PMID: 35039442 / doi: 10.26508/lsa.202101314
Contact Info: Emmie de Wit: [email protected]
URL: https://www.life-science-alliance.org/content/5/4/e202101314
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Paris-East Creteil University; Universite Paris-Saclay Fontenay-aux-Roses; CEA-INSERM, University of Lille; Universite de Lyon; Centre de Recherche en Cancerologie de Lyon; Institut Curie; Justus Liebig University
Keywords: SARS-CoV-2, lung cell senescence, RNA analysis, pathology, humans, primates
Summary of Study: Cell senescence was monitored in cynomolgus macaques to evaluate potential links between SARS-CoV-2 infection and aging. Data constitute the first evidence of temporal and topographic relations between senescent cell accumulation and pulmonary lesions induced by SARS-CoV-2.
References: PMID: 34648725 / doi: 10.1165/rcmb.2021-0205LE
Contact Info: Serge Adnot: [email protected]
URL: https://www.atsjournals.org/doi/10.1165/rcmb.2021-0205LE?url_ver=Z39.88-2003&rf…
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Paris-East Creteil University; Universite Paris-Saclay Fontenay-aux-Roses; CEA-INSERM, University of Lille; Universite de Lyon; Centre de Recherche en Cancerologie de Lyon; Institut Curie; Justus Liebig University
Keywords: SARS-CoV-2, lung cell senescence, RNA analysis, pathology, humans, primates
Summary of Study: Cell senescence was monitored in cynomolgus macaques to evaluate potential links between SARS-CoV-2 infection and aging. Data constitute the first evidence of temporal and topographic relations between senescent cell accumulation and pulmonary lesions induced by SARS-CoV-2.
References: PMID: 34648725 / doi: 10.1165/rcmb.2021-0205LE
Contact Info: Serge Adnot: [email protected]
URL: https://www.atsjournals.org/doi/10.1165/rcmb.2021-0205LE?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Central Florida; Tulane National Primate Research Center
Keywords: SARS-CoV-2, pathology, heart, immune response, primates
Summary of Study: SARS-CoV-2 infection is characterized by an exaggerated inflammatory immune response in the heart, which possibly contributes to myocardial remodeling and subsequent fibrosis.
References: PMID: 35203260 / doi: 10.3390/cells11040611
Contact Info: Manish Kumar Gupta: [email protected]
URL: https://www.mdpi.com/2073-4409/11/4/611
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Central Florida; Tulane National Primate Research Center
Keywords: SARS-CoV-2, pathology, heart, immune response, primates
Summary of Study: SARS-CoV-2 infection is characterized by an exaggerated inflammatory immune response in the heart, which possibly contributes to myocardial remodeling and subsequent fibrosis.
References: PMID: 35203260 / doi: 10.3390/cells11040611
Contact Info: Manish Kumar Gupta: [email protected]
URL: https://www.mdpi.com/2073-4409/11/4/611
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Inovio Pharmaceuticals; The Wistar Institute
Keywords: SARS-CoV-2, DNA vaccine, prime-boost vaccination, immune response, primates
Summary of Study: Illustrates the durability of immunity following vaccination with synthetic DNA vaccine encoding the wild-type Spike protein, INO-4800, and additionally supports the use of either INO-4800 or INO-4802 in prime-boost regimens.
References: PMID: 35428500 / doi: 10.1016/j.vaccine.2022.03.060
Contact Info: Kate Broderick: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22003681?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Inovio Pharmaceuticals; The Wistar Institute
Keywords: SARS-CoV-2, DNA vaccine, prime-boost vaccination, immune response, primates
Summary of Study: Illustrates the durability of immunity following vaccination with synthetic DNA vaccine encoding the wild-type Spike protein, INO-4800, and additionally supports the use of either INO-4800 or INO-4802 in prime-boost regimens.
References: PMID: 35428500 / doi: 10.1016/j.vaccine.2022.03.060
Contact Info: Kate Broderick: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22003681?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Guangzhou Medical University; Macau University of Science and Technology; St. Januario Central Hospital Macau
Keywords: SARS-CoV-2, homologous or heterogenous vaccination boosters, virus variants, primates
Summary of Study: The Omicron BA.1 variant showed little sensitivity to all of the neutralizing antibodies evaluated in this study, adding to the emerging body of evidence that the resistance to neutralizing antibodies is conferred largely by the mutations in the RBD, since pseudovirus harboring additional spike protein mutations did not significantly change the resistance to neutralizing activity. A recombinant RBD protein vaccine may be a promising approach for future vaccine development.
References: PMID: 35592756 / doi: 10.1002/mco2.143
Contact Info: Kang Zhang: [email protected]; Gen Li: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095991/
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Guangzhou Medical University; Macau University of Science and Technology; St. Januario Central Hospital Macau
Keywords: SARS-CoV-2, homologous or heterogenous vaccination boosters, virus variants, primates
Summary of Study: The Omicron BA.1 variant showed little sensitivity to all of the neutralizing antibodies evaluated in this study, adding to the emerging body of evidence that the resistance to neutralizing antibodies is conferred largely by the mutations in the RBD, since pseudovirus harboring additional spike protein mutations did not significantly change the resistance to neutralizing activity. A recombinant RBD protein vaccine may be a promising approach for future vaccine development.
References: PMID: 35592756 / doi: 10.1002/mco2.143
Contact Info: Kang Zhang: [email protected]; Gen Li: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095991/
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Affinivax; Ragon Institute of MGH, MIT, and Harvard; Boston Children's Hospital
Keywords: SARS-CoV-2, multiple antigen-presenting system vaccine, pathology, primates
Summary of Study: Multiple Antigen-Presenting System is a novel way to create a vaccine presenting proteins on a polymer and is able to induce antibody formation and reduce viral load in NHPS.
References: PMID: 35891233 / doi: 10.3390/vaccines10071069
Contact Info: Gilles Besin: [email protected]
URL: https://www.mdpi.com/2076-393X/10/7/1069
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Affinivax; Ragon Institute of MGH, MIT, and Harvard; Boston Children's Hospital
Keywords: SARS-CoV-2, multiple antigen-presenting system vaccine, pathology, primates
Summary of Study: Multiple Antigen-Presenting System is a novel way to create a vaccine presenting proteins on a polymer and is able to induce antibody formation and reduce viral load in NHPS.
References: PMID: 35891233 / doi: 10.3390/vaccines10071069
Contact Info: Gilles Besin: [email protected]
URL: https://www.mdpi.com/2076-393X/10/7/1069
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Washington; Stanford University School of Medicine; University of Louisiana at Lafayette; Washington University School of Medicine
Keywords: SARS-CoV-2, vaccine, immune response, mice, primates
Summary of Study: Non-human primates and humans are better models than mice when looking at the potency of neutralizing antibody responses from vaccine as their immune and caution should be used when generalizing data from mouse models.
References: PMID: 35988541 / doi: 10.1016/j.celrep.2022.111299
Contact Info: David Veesler: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2211124722011196?via%3Dihub
NHP Species: pigtail macaques, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Washington; Stanford University School of Medicine; University of Louisiana at Lafayette; Washington University School of Medicine
Keywords: SARS-CoV-2, vaccine, immune response, mice, primates
Summary of Study: Non-human primates and humans are better models than mice when looking at the potency of neutralizing antibody responses from vaccine as their immune and caution should be used when generalizing data from mouse models.
References: PMID: 35988541 / doi: 10.1016/j.celrep.2022.111299
Contact Info: David Veesler: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2211124722011196?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID Laboratory of Virology and NIAID Rocky Mountain Veterinary Branch, Hamilton, MT
Keywords: SARS-CoV-2, pathology, virus variants, primates
Summary of Study: Omicron BA.1 and BA.2 are attenuated in rhesus macaques as compared to Delta
References: doi: 10.1126/sciadv.ade1860
Contact Info: Kyle Rosenke: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.ade1860
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID Laboratory of Virology and NIAID Rocky Mountain Veterinary Branch, Hamilton, MT
Keywords: SARS-CoV-2, pathology, virus variants, primates
Summary of Study: Omicron BA.1 and BA.2 are attenuated in rhesus macaques as compared to Delta
References: doi: 10.1126/sciadv.ade1860
Contact Info: Kyle Rosenke: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.ade1860
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Medicago Inc.; Stanford University School of Medicine; Tulane National Primate Research Center; Tulane University School of Medicine; Research Institute of the McGill University Health Centre
Keywords: SARS-CoV-2, unadjuvanted and adjuvanted formulations, recombinant plant-derived virus-like particle vaccine, safety, immune response, primates
Summary of Study: A VLP bearing a SARS-CoV-2 spike protein vaccine candidate formulated with Adjuvant System 03 (AS03) was shown to be safe and effective and was therefore selected for vaccine development and clinical trials.
References: PMID: 34983950 / doi: 10.1038/s41423-021-00809-2
Contact Info: Brian Ward: [email protected]
URL: https://www.nature.com/articles/s41423-021-00809-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Medicago Inc.; Stanford University School of Medicine; Tulane National Primate Research Center; Tulane University School of Medicine; Research Institute of the McGill University Health Centre
Keywords: SARS-CoV-2, unadjuvanted and adjuvanted formulations, recombinant plant-derived virus-like particle vaccine, safety, immune response, primates
Summary of Study: A VLP bearing a SARS-CoV-2 spike protein vaccine candidate formulated with Adjuvant System 03 (AS03) was shown to be safe and effective and was therefore selected for vaccine development and clinical trials.
References: PMID: 34983950 / doi: 10.1038/s41423-021-00809-2
Contact Info: Brian Ward: [email protected]
URL: https://www.nature.com/articles/s41423-021-00809-2
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Ology Bioservices; Harvard Medical School, Vanderbilt University Medical Center; US Department of Defense; Logistics Management Institute; Washington University School of Medicine; Bioqual, Inc.
Keywords: SARS-CoV-2, neutralizing human monoclonal antibodies, primates
Summary of Study: Neutralizing antibodies with extended half-life and lacking Fc-mediated effector functions are efficient for pre-exposure prophylaxis of SARS-CoV-2 infection in NHPs.
References: PMID: 35132398 / doi: 10.1016/j.medj.2022.01.004
Contact Info: Dan Barouch: [email protected]
URL: https://www.cell.com/med/fulltext/S2666-6340(22)00039-3?_returnURL=https%3A%2F%…
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Ology Bioservices; Harvard Medical School, Vanderbilt University Medical Center; US Department of Defense; Logistics Management Institute; Washington University School of Medicine; Bioqual, Inc.
Keywords: SARS-CoV-2, neutralizing human monoclonal antibodies, primates
Summary of Study: Neutralizing antibodies with extended half-life and lacking Fc-mediated effector functions are efficient for pre-exposure prophylaxis of SARS-CoV-2 infection in NHPs.
References: PMID: 35132398 / doi: 10.1016/j.medj.2022.01.004
Contact Info: Dan Barouch: [email protected]
URL: https://www.cell.com/med/fulltext/S2666-6340(22)00039-3?_returnURL=https%3A%2F%…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: MIT; Harvard Medical School; University of Kansas; Tufts University; SpyBiotech Limited; Bioqual; Bill and Melinda Gates Medical Research Institute; Serum Institute of India; University of Oxford; Ragon Institute of MGH, MIT, and Harvard; Massachusetts Consortium on Pathogen Readiness
Keywords: SARS-CoV-2, receptor binding domain, HBsAg virus–like particles, immune response, primates
Summary of Study: A clinical-stage vaccine candidate comprising a SARS-CoV-2 receptor binding domain-hepatitis B surface antigen virus-like particle elicited protective immunity in cynomolgus macaques.
References: PMID: 35294244 / doi: 10.1126/sciadv.abl6015
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.abl6015?url_ver=Z39.88-2003&rfr_id=o…
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: MIT; Harvard Medical School; University of Kansas; Tufts University; SpyBiotech Limited; Bioqual; Bill and Melinda Gates Medical Research Institute; Serum Institute of India; University of Oxford; Ragon Institute of MGH, MIT, and Harvard; Massachusetts Consortium on Pathogen Readiness
Keywords: SARS-CoV-2, receptor binding domain, HBsAg virus–like particles, immune response, primates
Summary of Study: A clinical-stage vaccine candidate comprising a SARS-CoV-2 receptor binding domain-hepatitis B surface antigen virus-like particle elicited protective immunity in cynomolgus macaques.
References: PMID: 35294244 / doi: 10.1126/sciadv.abl6015
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.abl6015?url_ver=Z39.88-2003&rfr_id=o…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Tufts University Cummings School of Veterinary Medicine; Vaccine & Gene Therapy Institute/OHSU; University of Montreal; Oregon National Primate Research Center; Ragon Institute of MGH, MIT, and Harvard
Keywords: SARS-CoV-2, Ad26.COV2.S vaccine, transcriptional and proteomic profiling, primates
Summary of Study: Study showed that vaccination with Ad26.COV2.S protected hamsters and rhesus macaques challenged with SARS-CoV-2 from developing excessive proinflammatory responses mediated by IL-6 and IL-1, macrophages, and neutrophil activation.
References: PMID: 35395058 / doi: 10.1371/journal.ppat.1009990
Contact Info: Dan Barouch: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009990
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Tufts University Cummings School of Veterinary Medicine; Vaccine & Gene Therapy Institute/OHSU; University of Montreal; Oregon National Primate Research Center; Ragon Institute of MGH, MIT, and Harvard
Keywords: SARS-CoV-2, Ad26.COV2.S vaccine, transcriptional and proteomic profiling, primates
Summary of Study: Study showed that vaccination with Ad26.COV2.S protected hamsters and rhesus macaques challenged with SARS-CoV-2 from developing excessive proinflammatory responses mediated by IL-6 and IL-1, macrophages, and neutrophil activation.
References: PMID: 35395058 / doi: 10.1371/journal.ppat.1009990
Contact Info: Dan Barouch: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009990
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Cellid Co., Ltd; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology; International Vaccine Institute; Seoul National University
Keywords: SARS-CoV-2, adenovirus, AdCLD-CoV19 vaccine, immune response, virus variants, primates
Summary of Study: AdCLD-CoV19 can prevent SARS-CoV-2 with a single vaccination, and the new vaccine administration strategy that responds to various variants can maintain the efficacy of the vaccine.
References: PMID: 35632468 / doi: 10.3390/vaccines10050712
Contact Info: Chang-Yuil Kang: [email protected]
URL: https://www.mdpi.com/2076-393X/10/5/712
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Cellid Co., Ltd; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology; International Vaccine Institute; Seoul National University
Keywords: SARS-CoV-2, adenovirus, AdCLD-CoV19 vaccine, immune response, virus variants, primates
Summary of Study: AdCLD-CoV19 can prevent SARS-CoV-2 with a single vaccination, and the new vaccine administration strategy that responds to various variants can maintain the efficacy of the vaccine.
References: PMID: 35632468 / doi: 10.3390/vaccines10050712
Contact Info: Chang-Yuil Kang: [email protected]
URL: https://www.mdpi.com/2076-393X/10/5/712
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Bordeaux; Université Paris-Saclay; Vaccine Research Institute Créteil; Inserm U955 Créteil; Baylor Scott and White Research Institute; Institut Pasteur Paris; CNRS UMR 3569; University of Amsterdam Amsterdam Infection & Immunity Institute Amsterdam; Hôpital Henri-Mondor Albert-Chenevier; CHU Bordeaux
Keywords: SARS-CoV-2, mathematical modelling, vaccine, viral dynamics, primates
Summary of Study: A model-based approach can identify mechanistic correlates of protection that vaccines provide against infection, such that inhibition of the receptor-binding domain to ACE2 represents a strong mechanism of protection.
References: PMID: 35801637 / doi: 10.7554/eLife.75427
Contact Info: Rodolphe Thiébaut: [email protected]
URL: https://elifesciences.org/articles/75427
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Bordeaux; Université Paris-Saclay; Vaccine Research Institute Créteil; Inserm U955 Créteil; Baylor Scott and White Research Institute; Institut Pasteur Paris; CNRS UMR 3569; University of Amsterdam Amsterdam Infection & Immunity Institute Amsterdam; Hôpital Henri-Mondor Albert-Chenevier; CHU Bordeaux
Keywords: SARS-CoV-2, mathematical modelling, vaccine, viral dynamics, primates
Summary of Study: A model-based approach can identify mechanistic correlates of protection that vaccines provide against infection, such that inhibition of the receptor-binding domain to ACE2 represents a strong mechanism of protection.
References: PMID: 35801637 / doi: 10.7554/eLife.75427
Contact Info: Rodolphe Thiébaut: [email protected]
URL: https://elifesciences.org/articles/75427
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Université Paris-Saclay; Université de Paris; Laboratoire de Pharmacocinétique et Toxicologie; Institut Pasteur; Centre International de Recherche en Infectiologie; Unité des Virus Emergents, Aix Marseille Univ; VirNext, Université Claude Bernard Lyon 1; University Hospital, Bordeaux & Inserm
Keywords: SARS-CoV-2, Zika, favipiravir, antiviral activity, primates
Summary of Study: A nucleoside analogue with activity against RNA viruses shows antiviral activity that reduces viral load and kinetics in Zika, but not COVID-19.
References: PMID: 36042198 / doi: 10.1038/s41467-022-32565-w
Contact Info: Roger Le Grand: [email protected]; Jeremie Guedj: [email protected]
URL: https://www.nature.com/articles/s41467-022-32565-w
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Université Paris-Saclay; Université de Paris; Laboratoire de Pharmacocinétique et Toxicologie; Institut Pasteur; Centre International de Recherche en Infectiologie; Unité des Virus Emergents, Aix Marseille Univ; VirNext, Université Claude Bernard Lyon 1; University Hospital, Bordeaux & Inserm
Keywords: SARS-CoV-2, Zika, favipiravir, antiviral activity, primates
Summary of Study: A nucleoside analogue with activity against RNA viruses shows antiviral activity that reduces viral load and kinetics in Zika, but not COVID-19.
References: PMID: 36042198 / doi: 10.1038/s41467-022-32565-w
Contact Info: Roger Le Grand: [email protected]; Jeremie Guedj: [email protected]
URL: https://www.nature.com/articles/s41467-022-32565-w
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chulalongkorn University, Bangkok, Thailand; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathum Thani, Thailand; Baiya Phytopharm Co., Ltd., Bangkok, Thailand; Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand; National Primate Research Center of Thailand-Chulalongkorn University, Saraburi, Thailand.
Keywords: SARS-CoV-2, recombinant subunit vaccine, plants, immune response, mice, primates
Summary of Study: Three-dose regimen of Baiya SARS-CoV-2 Vax 1 vaccine elicits neutralizing immune response against SARS-CoV-2 variants.
References: doi: 10.3389/fpls.2022.901978
Contact Info: Waranyoo Phoolcharoen: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fpls.2022.901978/full
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chulalongkorn University, Bangkok, Thailand; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathum Thani, Thailand; Baiya Phytopharm Co., Ltd., Bangkok, Thailand; Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand; National Primate Research Center of Thailand-Chulalongkorn University, Saraburi, Thailand.
Keywords: SARS-CoV-2, recombinant subunit vaccine, plants, immune response, mice, primates
Summary of Study: Three-dose regimen of Baiya SARS-CoV-2 Vax 1 vaccine elicits neutralizing immune response against SARS-CoV-2 variants.
References: doi: 10.3389/fpls.2022.901978
Contact Info: Waranyoo Phoolcharoen: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fpls.2022.901978/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIBSC Division of Infectious Disease Diagnostics, Division of Virology, Division of Analytical and Biological Sciences, other, Hertfordshire, UK
Keywords: SARS-CoV-2, virology, molecular and pathological outcomes, several animal species, primates
Summary of Study: Viral outcomes in multiple species
References: doi: 10.1038/s41598-022-23339-x
Contact Info: Neil Berry: [email protected]
URL: https://www.nature.com/articles/s41598-022-23339-x
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIBSC Division of Infectious Disease Diagnostics, Division of Virology, Division of Analytical and Biological Sciences, other, Hertfordshire, UK
Keywords: SARS-CoV-2, virology, molecular and pathological outcomes, several animal species, primates
Summary of Study: Viral outcomes in multiple species
References: doi: 10.1038/s41598-022-23339-x
Contact Info: Neil Berry: [email protected]
URL: https://www.nature.com/articles/s41598-022-23339-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: prevention
NPRC/Institute: AstraZeneca; BIOQUAL; Vanderbilt University; USAMRIID
Keywords: SARS-CoV-2, monoclonal antibody combination, AZD7442,virus protection, humans, primates
Summary of Study: AZD7442, a monoclonal antibody comprised of AZD8895 and AZD1061, demonstrated potent in vitro neutralization against SARS-CoV-2 VOCs, in vivo efficacy in both prevention and treatment settings of SARS-CoV-2 infection in NHPs, and extended half-life in NHPs and healthy adult participants.
References: PMID: 35076282 / doi: 10.1126/scitranslmed.abl8124
Contact Info: Mark Esser: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abl8124?url_ver=Z39.88-2003&rf…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: prevention
NPRC/Institute: AstraZeneca; BIOQUAL; Vanderbilt University; USAMRIID
Keywords: SARS-CoV-2, monoclonal antibody combination, AZD7442,virus protection, humans, primates
Summary of Study: AZD7442, a monoclonal antibody comprised of AZD8895 and AZD1061, demonstrated potent in vitro neutralization against SARS-CoV-2 VOCs, in vivo efficacy in both prevention and treatment settings of SARS-CoV-2 infection in NHPs, and extended half-life in NHPs and healthy adult participants.
References: PMID: 35076282 / doi: 10.1126/scitranslmed.abl8124
Contact Info: Mark Esser: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abl8124?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Northwestern University; Tulane National Primate Research Center; NIAID; Sanford Burnham Prebys Medical Discovery Institute; Bioqual; New Iberia Research Center
Keywords: SARS-CoV-2, antibody-based in vivo probe system, lungs, primates
Summary of Study: Results provide proof of concept for the use of in vivo antibody-based probes to study SARS-CoV-2 infection dynamics in rhesus macaques.
References: PMID: 35003140 / doi: 10.3389/fimmu.2021.810047
Contact Info: Thomas Hope: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.810047/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Northwestern University; Tulane National Primate Research Center; NIAID; Sanford Burnham Prebys Medical Discovery Institute; Bioqual; New Iberia Research Center
Keywords: SARS-CoV-2, antibody-based in vivo probe system, lungs, primates
Summary of Study: Results provide proof of concept for the use of in vivo antibody-based probes to study SARS-CoV-2 infection dynamics in rhesus macaques.
References: PMID: 35003140 / doi: 10.3389/fimmu.2021.810047
Contact Info: Thomas Hope: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.810047/full
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Ragon Institution of MGH, MIT, and Harvard; Bioqual; Washington University School of Medicine; Emory School of Medicine, Tufts University Cummings School of Veterinary Medicine
Keywords: SARS-CoV-2, mRNA-based BNT162b2 vaccine, virus variants, immune response, primates
Summary of Study: BNT162b2 and Ad26.COV2.S provided robust protection against high-dose challenge with the SARS-CoV-2 Omicron variant in macaques. Protection against this highly mutated SARS-CoV-2 variant correlated with both humoral and cellular immune responses.
References: PMID: 35169798 / doi: 10.1101/2022.02.06.479285
Contact Info: Dan Barouch: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.02.06.479285v1
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Ragon Institution of MGH, MIT, and Harvard; Bioqual; Washington University School of Medicine; Emory School of Medicine, Tufts University Cummings School of Veterinary Medicine
Keywords: SARS-CoV-2, mRNA-based BNT162b2 vaccine, virus variants, immune response, primates
Summary of Study: BNT162b2 and Ad26.COV2.S provided robust protection against high-dose challenge with the SARS-CoV-2 Omicron variant in macaques. Protection against this highly mutated SARS-CoV-2 variant correlated with both humoral and cellular immune responses.
References: PMID: 35169798 / doi: 10.1101/2022.02.06.479285
Contact Info: Dan Barouch: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.02.06.479285v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; Yerkes National Primate Research Center; Emory School of Medicine; Bioqual; Modernal; Harvard T.H. Chan School of Public Health
Keywords: SARS-CoV-2, vaccination, mRNA-1273 or mRNA-Omicron boost, pathology, primates
Summary of Study: Boosting with homologous mRNA-1273 or mRNA-Omicron leads to comparable and significant increases in neutralizing antibody responses against all VOC, including Omicron.
References: PMID: 35447072 / doi: 10.1016/j.cell.2022.03.038
Contact Info: Daniel Douek: [email protected]; Robert Seder: [email protected]
URL: https://www.cell.com/cell/fulltext/S0092-8674(22)00388-9?_returnURL=https%3A%2F…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; Yerkes National Primate Research Center; Emory School of Medicine; Bioqual; Modernal; Harvard T.H. Chan School of Public Health
Keywords: SARS-CoV-2, vaccination, mRNA-1273 or mRNA-Omicron boost, pathology, primates
Summary of Study: Boosting with homologous mRNA-1273 or mRNA-Omicron leads to comparable and significant increases in neutralizing antibody responses against all VOC, including Omicron.
References: PMID: 35447072 / doi: 10.1016/j.cell.2022.03.038
Contact Info: Daniel Douek: [email protected]; Robert Seder: [email protected]
URL: https://www.cell.com/cell/fulltext/S0092-8674(22)00388-9?_returnURL=https%3A%2F…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, longitudinal analyses, lungs, intestines, immune response, primates
Summary of Study: Findings indicate an imbalance of immune dynamic in intestinal mucosa during SARS-CoV-2 infection, which may underlie ongoing rectal viral shedding and mild tissue damage.
References: PMID: 35594870 / doi: 10.1016/j.celrep.2022.110864
Contact Info: Zhanlong He: [email protected]; Haijing Shi: [email protected]; Qihan Li: [email protected]; Longing Liu: [email protected]
URL: https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00637-4?_returnURL=htt…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, longitudinal analyses, lungs, intestines, immune response, primates
Summary of Study: Findings indicate an imbalance of immune dynamic in intestinal mucosa during SARS-CoV-2 infection, which may underlie ongoing rectal viral shedding and mild tissue damage.
References: PMID: 35594870 / doi: 10.1016/j.celrep.2022.110864
Contact Info: Zhanlong He: [email protected]; Haijing Shi: [email protected]; Qihan Li: [email protected]; Longing Liu: [email protected]
URL: https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00637-4?_returnURL=htt…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Zalgen Labs, LLC; Duke University Medical Center, Duke Human Vaccine Institute;
Keywords: SARS-CoV-2, viral kinetics, immune response, primates
Summary of Study: Pulmonary outcome of COVID-19 is not influenced by route of infection even though clinical onset shows differences.
References: PMID: 35789343 / doi: 10.1371/journal.ppat.1010618
Contact Info: Chad Roy: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010618
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Zalgen Labs, LLC; Duke University Medical Center, Duke Human Vaccine Institute;
Keywords: SARS-CoV-2, viral kinetics, immune response, primates
Summary of Study: Pulmonary outcome of COVID-19 is not influenced by route of infection even though clinical onset shows differences.
References: PMID: 35789343 / doi: 10.1371/journal.ppat.1010618
Contact Info: Chad Roy: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010618
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Stanford University; University of Washington; Emory National Primate Research Center, and Emory University School of Medicine; Tulane National Primate Research Center; University of Louisiana at Lafayette; University of Maryland School of Medicine; University of California, San Diego; La Jolla Institute for Immunology; GSK; Bill and Melinda Gates Foundation; Tulane University School of Medicine;
Keywords: SARS-CoV-2, adjuvanted subunit vaccine, immune response, primates
Summary of Study: An adjuvanted subunit vaccine results in significant and durable memory T- and B-cell responses to Beta and Omicron variants and was found to suppress viral load and protect lungs after Omicron infection.
References: PMID: 35976993 / doi: 10.1126/scitranslmed.abq4130
Contact Info: Bali Pulendran: [email protected]
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abq4130?rfr_dat=cr_pub++0…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Stanford University; University of Washington; Emory National Primate Research Center, and Emory University School of Medicine; Tulane National Primate Research Center; University of Louisiana at Lafayette; University of Maryland School of Medicine; University of California, San Diego; La Jolla Institute for Immunology; GSK; Bill and Melinda Gates Foundation; Tulane University School of Medicine;
Keywords: SARS-CoV-2, adjuvanted subunit vaccine, immune response, primates
Summary of Study: An adjuvanted subunit vaccine results in significant and durable memory T- and B-cell responses to Beta and Omicron variants and was found to suppress viral load and protect lungs after Omicron infection.
References: PMID: 35976993 / doi: 10.1126/scitranslmed.abq4130
Contact Info: Bali Pulendran: [email protected]
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abq4130?rfr_dat=cr_pub++0…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Beijing Institute for Brain Disorders, Capital Medical University, China; State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing , numerous others.
Keywords: SARS-CoV-2, single-nucleus transcriptomics, pathology, immune response, primates
Summary of Study: Single-nucleus transcriptomic profiling of multiple organs
References: doi: 10.24272/j.issn.2095-8137.2022.443
Contact Info: Xiaoqun Wang: nc.ude.unb@gnawnuqoaix
URL: https://www.zoores.ac.cn/en/article/doi/10.24272/j.issn.2095-8137.2022.443
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Beijing Institute for Brain Disorders, Capital Medical University, China; State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing , numerous others.
Keywords: SARS-CoV-2, single-nucleus transcriptomics, pathology, immune response, primates
Summary of Study: Single-nucleus transcriptomic profiling of multiple organs
References: doi: 10.24272/j.issn.2095-8137.2022.443
Contact Info: Xiaoqun Wang: nc.ude.unb@gnawnuqoaix
URL: https://www.zoores.ac.cn/en/article/doi/10.24272/j.issn.2095-8137.2022.443
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, proteomic and phosphoproteomic profiling, lung and liver pathology, primates
Summary of Study: Proteomic and phosphoproteomic profiling of SARS-CoV-2-infected lung and liver tissues showed potentially active protein synthesis and processing, and dysregulated ECM, cell-to-cell junction, and cytoskeleton but no fibrosis in both the infected lung and liver.
References: PMID: 35091530 / doi: 10.1038/s41392-022-00882-7
Contact Info: Shaui-Yao Lu: [email protected]
URL: https://www.nature.com/articles/s41392-022-00882-7
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, proteomic and phosphoproteomic profiling, lung and liver pathology, primates
Summary of Study: Proteomic and phosphoproteomic profiling of SARS-CoV-2-infected lung and liver tissues showed potentially active protein synthesis and processing, and dysregulated ECM, cell-to-cell junction, and cytoskeleton but no fibrosis in both the infected lung and liver.
References: PMID: 35091530 / doi: 10.1038/s41392-022-00882-7
Contact Info: Shaui-Yao Lu: [email protected]
URL: https://www.nature.com/articles/s41392-022-00882-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Institute of Biological Products; Chinese Academy of Medicine Sciences & Peking Union Medical College
Keywords: SARS-CoV-2, recombinant protein subunit vaccine and an inactivated vaccine, virus variants, primates
Summary of Study: Both vaccines evaluated in this study significantly reduced the viral load in the respiratory tract, alleviated pathological changes, and relieved lung inflammation in vaccinated macaques. The possible contribution of antibodies possessing neutralizing reactivity or cell-mediated cytotoxicity and immune memory to vaccine induced protection was also highlighted.
References: PMID: 35241645 / doi: 10.1038/s41392-022-00926-y
Contact Info: Junzhi Wang: [email protected]
URL: https://www.nature.com/articles/s41392-022-00926-y
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Institute of Biological Products; Chinese Academy of Medicine Sciences & Peking Union Medical College
Keywords: SARS-CoV-2, recombinant protein subunit vaccine and an inactivated vaccine, virus variants, primates
Summary of Study: Both vaccines evaluated in this study significantly reduced the viral load in the respiratory tract, alleviated pathological changes, and relieved lung inflammation in vaccinated macaques. The possible contribution of antibodies possessing neutralizing reactivity or cell-mediated cytotoxicity and immune memory to vaccine induced protection was also highlighted.
References: PMID: 35241645 / doi: 10.1038/s41392-022-00926-y
Contact Info: Junzhi Wang: [email protected]
URL: https://www.nature.com/articles/s41392-022-00926-y
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Tulane National Primate Research Center
Keywords: SARS-CoV-2, noncompeting antibody cocktail, vaccine, immune response, primates
Summary of Study: A neutralizing mAB cocktail with extended half-life can be delivered intramuscularly to provide prophylactic protection against infection in rhesus macaques.
References: PMID: 35291730 / doi: 10.1016/j.medj.2022.02.004
Contact Info: Jay Rappaport: [email protected]
URL: https://www.cell.com/med/fulltext/S2666-6340(22)00087-3?_returnURL=https%3A%2F%…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Tulane National Primate Research Center
Keywords: SARS-CoV-2, noncompeting antibody cocktail, vaccine, immune response, primates
Summary of Study: A neutralizing mAB cocktail with extended half-life can be delivered intramuscularly to provide prophylactic protection against infection in rhesus macaques.
References: PMID: 35291730 / doi: 10.1016/j.medj.2022.02.004
Contact Info: Jay Rappaport: [email protected]
URL: https://www.cell.com/med/fulltext/S2666-6340(22)00087-3?_returnURL=https%3A%2F%…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Bavarian Nordic GmbH; Biomedical Primate Research Centre; Aarhus University; University of Copenhagen; AdaptVac Aps
Keywords: SARS-CoV-2, capsid virus-like particle-based vaccine ABNCoV2, immunogenicity, primates
Summary of Study: ABNCoV2 induced strong and long-lasting neutralizing antibody responses and efficacy against SARS-CoV-2 in NHP.
References: PMID: 35479095 / doi: 10.3389/fimmu.2022.857440
Contact Info: Ariane Volkmann: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.857440/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Bavarian Nordic GmbH; Biomedical Primate Research Centre; Aarhus University; University of Copenhagen; AdaptVac Aps
Keywords: SARS-CoV-2, capsid virus-like particle-based vaccine ABNCoV2, immunogenicity, primates
Summary of Study: ABNCoV2 induced strong and long-lasting neutralizing antibody responses and efficacy against SARS-CoV-2 in NHP.
References: PMID: 35479095 / doi: 10.3389/fimmu.2022.857440
Contact Info: Ariane Volkmann: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.857440/full
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Institute Pasteur; Universite Paris Saclay-INSERM; Beth Israel Deaconess Medical Center
Keywords: SARS-CoV-2, NK cells, macrophages, blood and bronchoalveolar lavage, immune response, primates
Summary of Study: Viral antigen is found in alveolar macrophages up to at least 18 months after SARS-CoV-2 infection in macaques. Additionally, an association was revealed between lower level of persisting viral antigen in alveolar macrophages and the activity of Spike-specific adaptive NH cells in the lung.
References: PMID: 35547853 / doi: 12.21203/rs.3.rs-1561222/v1
Contact Info: Nicolas Huot: [email protected]
URL: https://www.researchsquare.com/article/rs-1561222/v1
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Institute Pasteur; Universite Paris Saclay-INSERM; Beth Israel Deaconess Medical Center
Keywords: SARS-CoV-2, NK cells, macrophages, blood and bronchoalveolar lavage, immune response, primates
Summary of Study: Viral antigen is found in alveolar macrophages up to at least 18 months after SARS-CoV-2 infection in macaques. Additionally, an association was revealed between lower level of persisting viral antigen in alveolar macrophages and the activity of Spike-specific adaptive NH cells in the lung.
References: PMID: 35547853 / doi: 12.21203/rs.3.rs-1561222/v1
Contact Info: Nicolas Huot: [email protected]
URL: https://www.researchsquare.com/article/rs-1561222/v1