Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Vaxxiniy, Inc., Dallas, Texas; United Biomedical, Inc. (Taiwan and USA); Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX, USA; others.
Keywords: SARS-CoV-2, subunit protein-peptide vaccine, immunogenicity, rat, mice, primates
Summary of Study: RBD-Protein/Peptide Vaccine Elicits Broadly Neutralizing Antibodies
References: doi: 10.1080/22221751.2022.2140608
Contact Info: Farshad Guirakhoo: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2140608
NHP Species: cynomolgus macaques, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Vaxxiniy, Inc., Dallas, Texas; United Biomedical, Inc. (Taiwan and USA); Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX, USA; others.
Keywords: SARS-CoV-2, subunit protein-peptide vaccine, immunogenicity, rat, mice, primates
Summary of Study: RBD-Protein/Peptide Vaccine Elicits Broadly Neutralizing Antibodies
References: doi: 10.1080/22221751.2022.2140608
Contact Info: Farshad Guirakhoo: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2140608
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, numerous others
Keywords: SARS-CoV-2, vaccine, BNT162b2, mRNA-1273, infants, immune response, primates
Summary of Study: Protection in immunized infant macaques
References: doi: 10.1126/scitranslmed.add6383
Contact Info: Kristina de Paris: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.add6383
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, numerous others
Keywords: SARS-CoV-2, vaccine, BNT162b2, mRNA-1273, infants, immune response, primates
Summary of Study: Protection in immunized infant macaques
References: doi: 10.1126/scitranslmed.add6383
Contact Info: Kristina de Paris: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.add6383
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Medicago Inc.; Stanford University School of Medicine; Tulane National Primate Research Center; Tulane University School of Medicine; Research Institute of the McGill University Health Centre
Keywords: SARS-CoV-2, unadjuvanted and adjuvanted formulations, recombinant plant-derived virus-like particle vaccine, safety, immune response, primates
Summary of Study: A VLP bearing a SARS-CoV-2 spike protein vaccine candidate formulated with Adjuvant System 03 (AS03) was shown to be safe and effective and was therefore selected for vaccine development and clinical trials.
References: PMID: 34983950 / doi: 10.1038/s41423-021-00809-2
Contact Info: Brian Ward: [email protected]
URL: https://www.nature.com/articles/s41423-021-00809-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Medicago Inc.; Stanford University School of Medicine; Tulane National Primate Research Center; Tulane University School of Medicine; Research Institute of the McGill University Health Centre
Keywords: SARS-CoV-2, unadjuvanted and adjuvanted formulations, recombinant plant-derived virus-like particle vaccine, safety, immune response, primates
Summary of Study: A VLP bearing a SARS-CoV-2 spike protein vaccine candidate formulated with Adjuvant System 03 (AS03) was shown to be safe and effective and was therefore selected for vaccine development and clinical trials.
References: PMID: 34983950 / doi: 10.1038/s41423-021-00809-2
Contact Info: Brian Ward: [email protected]
URL: https://www.nature.com/articles/s41423-021-00809-2
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Ology Bioservices; Harvard Medical School, Vanderbilt University Medical Center; US Department of Defense; Logistics Management Institute; Washington University School of Medicine; Bioqual, Inc.
Keywords: SARS-CoV-2, neutralizing human monoclonal antibodies, primates
Summary of Study: Neutralizing antibodies with extended half-life and lacking Fc-mediated effector functions are efficient for pre-exposure prophylaxis of SARS-CoV-2 infection in NHPs.
References: PMID: 35132398 / doi: 10.1016/j.medj.2022.01.004
Contact Info: Dan Barouch: [email protected]
URL: https://www.cell.com/med/fulltext/S2666-6340(22)00039-3?_returnURL=https%3A//li…
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Ology Bioservices; Harvard Medical School, Vanderbilt University Medical Center; US Department of Defense; Logistics Management Institute; Washington University School of Medicine; Bioqual, Inc.
Keywords: SARS-CoV-2, neutralizing human monoclonal antibodies, primates
Summary of Study: Neutralizing antibodies with extended half-life and lacking Fc-mediated effector functions are efficient for pre-exposure prophylaxis of SARS-CoV-2 infection in NHPs.
References: PMID: 35132398 / doi: 10.1016/j.medj.2022.01.004
Contact Info: Dan Barouch: [email protected]
URL: https://www.cell.com/med/fulltext/S2666-6340(22)00039-3?_returnURL=https%3A//li…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: MIT; Harvard Medical School; University of Kansas; Tufts University; SpyBiotech Limited; Bioqual; Bill and Melinda Gates Medical Research Institute; Serum Institute of India; University of Oxford; Ragon Institute of MGH, MIT, and Harvard; Massachusetts Consortium on Pathogen Readiness
Keywords: SARS-CoV-2, receptor binding domain, HBsAg virus–like particles, immune response, primates
Summary of Study: A clinical-stage vaccine candidate comprising a SARS-CoV-2 receptor binding domain-hepatitis B surface antigen virus-like particle elicited protective immunity in cynomolgus macaques.
References: PMID: 35294244 / doi: 10.1126/sciadv.abl6015
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.abl6015?url_ver=Z39.88-2003&rfr_id=o…
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: MIT; Harvard Medical School; University of Kansas; Tufts University; SpyBiotech Limited; Bioqual; Bill and Melinda Gates Medical Research Institute; Serum Institute of India; University of Oxford; Ragon Institute of MGH, MIT, and Harvard; Massachusetts Consortium on Pathogen Readiness
Keywords: SARS-CoV-2, receptor binding domain, HBsAg virus–like particles, immune response, primates
Summary of Study: A clinical-stage vaccine candidate comprising a SARS-CoV-2 receptor binding domain-hepatitis B surface antigen virus-like particle elicited protective immunity in cynomolgus macaques.
References: PMID: 35294244 / doi: 10.1126/sciadv.abl6015
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.abl6015?url_ver=Z39.88-2003&rfr_id=o…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Tufts University Cummings School of Veterinary Medicine; Vaccine & Gene Therapy Institute/OHSU; University of Montreal; Oregon National Primate Research Center; Ragon Institute of MGH, MIT, and Harvard
Keywords: SARS-CoV-2, Ad26.COV2.S vaccine, transcriptional and proteomic profiling, primates
Summary of Study: Study showed that vaccination with Ad26.COV2.S protected hamsters and rhesus macaques challenged with SARS-CoV-2 from developing excessive proinflammatory responses mediated by IL-6 and IL-1, macrophages, and neutrophil activation.
References: PMID: 35395058 / doi: 10.1371/journal.ppat.1009990
Contact Info: Dan Barouch: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009990
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Tufts University Cummings School of Veterinary Medicine; Vaccine & Gene Therapy Institute/OHSU; University of Montreal; Oregon National Primate Research Center; Ragon Institute of MGH, MIT, and Harvard
Keywords: SARS-CoV-2, Ad26.COV2.S vaccine, transcriptional and proteomic profiling, primates
Summary of Study: Study showed that vaccination with Ad26.COV2.S protected hamsters and rhesus macaques challenged with SARS-CoV-2 from developing excessive proinflammatory responses mediated by IL-6 and IL-1, macrophages, and neutrophil activation.
References: PMID: 35395058 / doi: 10.1371/journal.ppat.1009990
Contact Info: Dan Barouch: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009990
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Massachusetts Institute of Technology; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University; Scripps Research Institute; University of Louisiana at Lafayette; Beth Israel Deaconess Medical Center, Harvard Medical School; Howard Hughes Medical Institute
Keywords: SARS-CoV-2, lipid-conjugated immunogen, intranasal vaccination, mice, primates
Summary of Study: To combat the problem of poor vaccine uptake across mucus and epithelial linings, intranasal immunization with amphilic albumin binding components was created with the ability to be delivered across the mucosal epithelium and generate an antigen-specific response.
References: PMID: 35857825 / doi: 10.1126/scitranslmed.abn1413
Contact Info: Darrell Irvine: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abn1413?url_ver=Z39.88-2003&rf…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Massachusetts Institute of Technology; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University; Scripps Research Institute; University of Louisiana at Lafayette; Beth Israel Deaconess Medical Center, Harvard Medical School; Howard Hughes Medical Institute
Keywords: SARS-CoV-2, lipid-conjugated immunogen, intranasal vaccination, mice, primates
Summary of Study: To combat the problem of poor vaccine uptake across mucus and epithelial linings, intranasal immunization with amphilic albumin binding components was created with the ability to be delivered across the mucosal epithelium and generate an antigen-specific response.
References: PMID: 35857825 / doi: 10.1126/scitranslmed.abn1413
Contact Info: Darrell Irvine: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abn1413?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: China Biotechnology Co.LTD; Beijing Chaoyang Hospital, Capital Medical University; Laboratory Animal Center, Academy of Military Medical Sciences
Keywords: SARS-CoV-2, angiotensin-converting enzyme 2, gene sequences, primates
Summary of Study: Angiotensin-converting enzyme (ACE2) binds to the SARS-CoV2 virus as a receptor, and variation of the ACE2 sequence and binding affinity may account for differences in susceptibility and responses to infection
References: PMID: 36105891 / doi: 10.1016/j.bsheal.2022.09.001
Contact Info: Xiaojun Zhou, Jingjing Zhao, Yefeng Qiu, Rui Jia
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461283/
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: China Biotechnology Co.LTD; Beijing Chaoyang Hospital, Capital Medical University; Laboratory Animal Center, Academy of Military Medical Sciences
Keywords: SARS-CoV-2, angiotensin-converting enzyme 2, gene sequences, primates
Summary of Study: Angiotensin-converting enzyme (ACE2) binds to the SARS-CoV2 virus as a receptor, and variation of the ACE2 sequence and binding affinity may account for differences in susceptibility and responses to infection
References: PMID: 36105891 / doi: 10.1016/j.bsheal.2022.09.001
Contact Info: Xiaojun Zhou, Jingjing Zhao, Yefeng Qiu, Rui Jia
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461283/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chin Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, China
Keywords: SARS-CoV-2, review, traditional Chinese medicine, mice, hamsters, primates
Summary of Study: Model exploration for discovering COVID-19 targeted traditional Chinese medicine
References: doi: 10.1016/j.heliyon.2022.e12333
Contact Info: Fengmei Lian: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2405844022036210?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chin Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, China
Keywords: SARS-CoV-2, review, traditional Chinese medicine, mice, hamsters, primates
Summary of Study: Model exploration for discovering COVID-19 targeted traditional Chinese medicine
References: doi: 10.1016/j.heliyon.2022.e12333
Contact Info: Fengmei Lian: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2405844022036210?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; University of Oxford
Keywords: SARS-CoV-2, age-specific immune responses, viral load, primates
Summary of Study: Despite similar disease outcomes, multiomics profiling suggests that age may delay or impair antiviral cellular immune responses and delay efficient return to homeostasis.
References: PMID: 35039442 / doi: 10.26508/lsa.202101314
Contact Info: Emmie de Wit: [email protected]
URL: https://www.life-science-alliance.org/content/5/4/e202101314
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; University of Oxford
Keywords: SARS-CoV-2, age-specific immune responses, viral load, primates
Summary of Study: Despite similar disease outcomes, multiomics profiling suggests that age may delay or impair antiviral cellular immune responses and delay efficient return to homeostasis.
References: PMID: 35039442 / doi: 10.26508/lsa.202101314
Contact Info: Emmie de Wit: [email protected]
URL: https://www.life-science-alliance.org/content/5/4/e202101314
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Paris-East Creteil University; Universite Paris-Saclay Fontenay-aux-Roses; CEA-INSERM, University of Lille; Universite de Lyon; Centre de Recherche en Cancerologie de Lyon; Institut Curie; Justus Liebig University
Keywords: SARS-CoV-2, lung cell senescence, RNA analysis, pathology, humans, primates
Summary of Study: Cell senescence was monitored in cynomolgus macaques to evaluate potential links between SARS-CoV-2 infection and aging. Data constitute the first evidence of temporal and topographic relations between senescent cell accumulation and pulmonary lesions induced by SARS-CoV-2.
References: PMID: 34648725 / doi: 10.1165/rcmb.2021-0205LE
Contact Info: Serge Adnot: [email protected]
URL: https://www.atsjournals.org/doi/10.1165/rcmb.2021-0205LE?url_ver=Z39.88-2003&rf…
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Paris-East Creteil University; Universite Paris-Saclay Fontenay-aux-Roses; CEA-INSERM, University of Lille; Universite de Lyon; Centre de Recherche en Cancerologie de Lyon; Institut Curie; Justus Liebig University
Keywords: SARS-CoV-2, lung cell senescence, RNA analysis, pathology, humans, primates
Summary of Study: Cell senescence was monitored in cynomolgus macaques to evaluate potential links between SARS-CoV-2 infection and aging. Data constitute the first evidence of temporal and topographic relations between senescent cell accumulation and pulmonary lesions induced by SARS-CoV-2.
References: PMID: 34648725 / doi: 10.1165/rcmb.2021-0205LE
Contact Info: Serge Adnot: [email protected]
URL: https://www.atsjournals.org/doi/10.1165/rcmb.2021-0205LE?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Central Florida; Tulane National Primate Research Center
Keywords: SARS-CoV-2, pathology, heart, immune response, primates
Summary of Study: SARS-CoV-2 infection is characterized by an exaggerated inflammatory immune response in the heart, which possibly contributes to myocardial remodeling and subsequent fibrosis.
References: PMID: 35203260 / doi: 10.3390/cells11040611
Contact Info: Manish Kumar Gupta: [email protected]
URL: https://www.mdpi.com/2073-4409/11/4/611
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Central Florida; Tulane National Primate Research Center
Keywords: SARS-CoV-2, pathology, heart, immune response, primates
Summary of Study: SARS-CoV-2 infection is characterized by an exaggerated inflammatory immune response in the heart, which possibly contributes to myocardial remodeling and subsequent fibrosis.
References: PMID: 35203260 / doi: 10.3390/cells11040611
Contact Info: Manish Kumar Gupta: [email protected]
URL: https://www.mdpi.com/2073-4409/11/4/611
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Inovio Pharmaceuticals; The Wistar Institute
Keywords: SARS-CoV-2, DNA vaccine, prime-boost vaccination, immune response, primates
Summary of Study: Illustrates the durability of immunity following vaccination with synthetic DNA vaccine encoding the wild-type Spike protein, INO-4800, and additionally supports the use of either INO-4800 or INO-4802 in prime-boost regimens.
References: PMID: 35428500 / doi: 10.1016/j.vaccine.2022.03.060
Contact Info: Kate Broderick: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22003681?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Inovio Pharmaceuticals; The Wistar Institute
Keywords: SARS-CoV-2, DNA vaccine, prime-boost vaccination, immune response, primates
Summary of Study: Illustrates the durability of immunity following vaccination with synthetic DNA vaccine encoding the wild-type Spike protein, INO-4800, and additionally supports the use of either INO-4800 or INO-4802 in prime-boost regimens.
References: PMID: 35428500 / doi: 10.1016/j.vaccine.2022.03.060
Contact Info: Kate Broderick: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22003681?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Guangzhou Medical University; Macau University of Science and Technology; St. Januario Central Hospital Macau
Keywords: SARS-CoV-2, homologous or heterogenous vaccination boosters, virus variants, primates
Summary of Study: The Omicron BA.1 variant showed little sensitivity to all of the neutralizing antibodies evaluated in this study, adding to the emerging body of evidence that the resistance to neutralizing antibodies is conferred largely by the mutations in the RBD, since pseudovirus harboring additional spike protein mutations did not significantly change the resistance to neutralizing activity. A recombinant RBD protein vaccine may be a promising approach for future vaccine development.
References: PMID: 35592756 / doi: 10.1002/mco2.143
Contact Info: Kang Zhang: [email protected]; Gen Li: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095991/
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Guangzhou Medical University; Macau University of Science and Technology; St. Januario Central Hospital Macau
Keywords: SARS-CoV-2, homologous or heterogenous vaccination boosters, virus variants, primates
Summary of Study: The Omicron BA.1 variant showed little sensitivity to all of the neutralizing antibodies evaluated in this study, adding to the emerging body of evidence that the resistance to neutralizing antibodies is conferred largely by the mutations in the RBD, since pseudovirus harboring additional spike protein mutations did not significantly change the resistance to neutralizing activity. A recombinant RBD protein vaccine may be a promising approach for future vaccine development.
References: PMID: 35592756 / doi: 10.1002/mco2.143
Contact Info: Kang Zhang: [email protected]; Gen Li: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095991/
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: Departments of Biochemistry and Pathology & Laboratory Medicine, Bhopal, India
Keywords: SARS-CoV-2, review, animal models, infection, pathology, primates
Summary of Study: Review of the immunological and clinical manifestations observed in various natural and genetically-modified animal models of numerous COVID-19 studies. The authors also summarize up-to-date laboratory findings on available and significant COVID-19 animal models, and put forth their perspective for the objective dependent usage of animal models.
References: PMID: 35757923 DOI: 10.1080/08830185.2022.2089666
Contact Info: Ashok Kumar: [email protected]
URL: https://www.tandfonline.com/doi/abs/10.1080/08830185.2022.2089666?journalCode=i…
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: Departments of Biochemistry and Pathology & Laboratory Medicine, Bhopal, India
Keywords: SARS-CoV-2, review, animal models, infection, pathology, primates
Summary of Study: Review of the immunological and clinical manifestations observed in various natural and genetically-modified animal models of numerous COVID-19 studies. The authors also summarize up-to-date laboratory findings on available and significant COVID-19 animal models, and put forth their perspective for the objective dependent usage of animal models.
References: PMID: 35757923 DOI: 10.1080/08830185.2022.2089666
Contact Info: Ashok Kumar: [email protected]
URL: https://www.tandfonline.com/doi/abs/10.1080/08830185.2022.2089666?journalCode=i…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Ragon Institute of MGH, MIT, and Harvard; University of Massachusetts; Bioqual
Keywords: SARS-CoV-2, adenovirus vector–based vaccine Ad26.COV2.S, immune response, primates
Summary of Study: Cytotoxic T-cells that are vaccine induced contribute to virus control, and when depleted, higher viral loads are seen in the respiratory tract.
References: PMID: 35943359 / doi: 10.1126/sciimmunol.abq7647
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/full/10.1126/sciimmunol.abq7647?rfr_dat=cr_pub%20%2…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Ragon Institute of MGH, MIT, and Harvard; University of Massachusetts; Bioqual
Keywords: SARS-CoV-2, adenovirus vector–based vaccine Ad26.COV2.S, immune response, primates
Summary of Study: Cytotoxic T-cells that are vaccine induced contribute to virus control, and when depleted, higher viral loads are seen in the respiratory tract.
References: PMID: 35943359 / doi: 10.1126/sciimmunol.abq7647
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/full/10.1126/sciimmunol.abq7647?rfr_dat=cr_pub%20%2…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shanghai East Hospital, Tongji University School of Medicine; Renji Hospital, Shanghai Jiao Tong University School of Medicine; National Kunming High-level Biosafety Primate Research Center; Naval Medical University; China Pharmaceutical University
Keywords: SARS-CoV-2, vaccine, single-cell transcriptome, immune response, primates
Summary of Study: A lipopolyplex-based mRNA vaccine provides a strong immune response by inhibiting the recruitment of proinflammatory macrophages and by providing lung protecting through inhibiting the apoptotic processes in long epithelial and endothelial cells.
References: PMID: 36124363 / doi: 10.1002/jmv.28161
Contact Info: Ang Lin: [email protected]; Zhenzhen Zhan: [email protected]; Xingguang Liu: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/jmv.28161
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shanghai East Hospital, Tongji University School of Medicine; Renji Hospital, Shanghai Jiao Tong University School of Medicine; National Kunming High-level Biosafety Primate Research Center; Naval Medical University; China Pharmaceutical University
Keywords: SARS-CoV-2, vaccine, single-cell transcriptome, immune response, primates
Summary of Study: A lipopolyplex-based mRNA vaccine provides a strong immune response by inhibiting the recruitment of proinflammatory macrophages and by providing lung protecting through inhibiting the apoptotic processes in long epithelial and endothelial cells.
References: PMID: 36124363 / doi: 10.1002/jmv.28161
Contact Info: Ang Lin: [email protected]; Zhenzhen Zhan: [email protected]; Xingguang Liu: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/jmv.28161
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Elicio Therapeutics; New Iberia Research Center, Louisiana
Keywords: SARS-CoV-2, vaccine, amphiphile adjuvant, immune response, mice, primates
Summary of Study: Lymph-node adjuvant-targeting to coordinate innate immunity and generate robust adaptive responses critical for vaccine efficacy.
References: doi: 10.1038/s41541-022-00560-3
Contact Info: Peter DeMuth: [email protected]
URL: https://www.nature.com/articles/s41541-022-00560-3
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Elicio Therapeutics; New Iberia Research Center, Louisiana
Keywords: SARS-CoV-2, vaccine, amphiphile adjuvant, immune response, mice, primates
Summary of Study: Lymph-node adjuvant-targeting to coordinate innate immunity and generate robust adaptive responses critical for vaccine efficacy.
References: doi: 10.1038/s41541-022-00560-3
Contact Info: Peter DeMuth: [email protected]
URL: https://www.nature.com/articles/s41541-022-00560-3
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shionogi & Co., Ltd., Biopharmaceutical Research Division, Osaka, Japan
Keywords: SARS-CoV-2, recombinant spike protein vaccine, virus variants, immune response
Summary of Study: Homologous and heterologous booster vaccinations of S-268019-b, a recombinant S protein-based vaccine
References: doi: 10.1016/j.vaccine.2022.10.092
Contact Info: Shinya Omoto: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22013792?via%3Dihub=
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shionogi & Co., Ltd., Biopharmaceutical Research Division, Osaka, Japan
Keywords: SARS-CoV-2, recombinant spike protein vaccine, virus variants, immune response
Summary of Study: Homologous and heterologous booster vaccinations of S-268019-b, a recombinant S protein-based vaccine
References: doi: 10.1016/j.vaccine.2022.10.092
Contact Info: Shinya Omoto: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22013792?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, proteomic and phosphoproteomic profiling, lung and liver pathology, primates
Summary of Study: Proteomic and phosphoproteomic profiling of SARS-CoV-2-infected lung and liver tissues showed potentially active protein synthesis and processing, and dysregulated ECM, cell-to-cell junction, and cytoskeleton but no fibrosis in both the infected lung and liver.
References: PMID: 35091530 / doi: 10.1038/s41392-022-00882-7
Contact Info: Shaui-Yao Lu: [email protected]
URL: https://www.nature.com/articles/s41392-022-00882-7
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, proteomic and phosphoproteomic profiling, lung and liver pathology, primates
Summary of Study: Proteomic and phosphoproteomic profiling of SARS-CoV-2-infected lung and liver tissues showed potentially active protein synthesis and processing, and dysregulated ECM, cell-to-cell junction, and cytoskeleton but no fibrosis in both the infected lung and liver.
References: PMID: 35091530 / doi: 10.1038/s41392-022-00882-7
Contact Info: Shaui-Yao Lu: [email protected]
URL: https://www.nature.com/articles/s41392-022-00882-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Institute of Biological Products; Chinese Academy of Medicine Sciences & Peking Union Medical College
Keywords: SARS-CoV-2, recombinant protein subunit vaccine and an inactivated vaccine, virus variants, primates
Summary of Study: Both vaccines evaluated in this study significantly reduced the viral load in the respiratory tract, alleviated pathological changes, and relieved lung inflammation in vaccinated macaques. The possible contribution of antibodies possessing neutralizing reactivity or cell-mediated cytotoxicity and immune memory to vaccine induced protection was also highlighted.
References: PMID: 35241645 / doi: 10.1038/s41392-022-00926-y
Contact Info: Junzhi Wang: [email protected]
URL: https://www.nature.com/articles/s41392-022-00926-y
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Institute of Biological Products; Chinese Academy of Medicine Sciences & Peking Union Medical College
Keywords: SARS-CoV-2, recombinant protein subunit vaccine and an inactivated vaccine, virus variants, primates
Summary of Study: Both vaccines evaluated in this study significantly reduced the viral load in the respiratory tract, alleviated pathological changes, and relieved lung inflammation in vaccinated macaques. The possible contribution of antibodies possessing neutralizing reactivity or cell-mediated cytotoxicity and immune memory to vaccine induced protection was also highlighted.
References: PMID: 35241645 / doi: 10.1038/s41392-022-00926-y
Contact Info: Junzhi Wang: [email protected]
URL: https://www.nature.com/articles/s41392-022-00926-y
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Tulane National Primate Research Center
Keywords: SARS-CoV-2, noncompeting antibody cocktail, vaccine, immune response, primates
Summary of Study: A neutralizing mAB cocktail with extended half-life can be delivered intramuscularly to provide prophylactic protection against infection in rhesus macaques.
References: PMID: 35291730 / doi: 10.1016/j.medj.2022.02.004
Contact Info: Jay Rappaport: [email protected]
URL: https://www.cell.com/med/fulltext/S2666-6340(22)00087-3?_returnURL=https%3A//li…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Tulane National Primate Research Center
Keywords: SARS-CoV-2, noncompeting antibody cocktail, vaccine, immune response, primates
Summary of Study: A neutralizing mAB cocktail with extended half-life can be delivered intramuscularly to provide prophylactic protection against infection in rhesus macaques.
References: PMID: 35291730 / doi: 10.1016/j.medj.2022.02.004
Contact Info: Jay Rappaport: [email protected]
URL: https://www.cell.com/med/fulltext/S2666-6340(22)00087-3?_returnURL=https%3A//li…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Bavarian Nordic GmbH; Biomedical Primate Research Centre; Aarhus University; University of Copenhagen; AdaptVac Aps
Keywords: SARS-CoV-2, capsid virus-like particle-based vaccine ABNCoV2, immunogenicity, primates
Summary of Study: ABNCoV2 induced strong and long-lasting neutralizing antibody responses and efficacy against SARS-CoV-2 in NHP.
References: PMID: 35479095 / doi: 10.3389/fimmu.2022.857440
Contact Info: Ariane Volkmann: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.857440/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Bavarian Nordic GmbH; Biomedical Primate Research Centre; Aarhus University; University of Copenhagen; AdaptVac Aps
Keywords: SARS-CoV-2, capsid virus-like particle-based vaccine ABNCoV2, immunogenicity, primates
Summary of Study: ABNCoV2 induced strong and long-lasting neutralizing antibody responses and efficacy against SARS-CoV-2 in NHP.
References: PMID: 35479095 / doi: 10.3389/fimmu.2022.857440
Contact Info: Ariane Volkmann: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.857440/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre (BPRC), Rijswijk, Netherlands; Department of Radiology and Nuclear Medicine, Tracer Center Amsterdam (TCA), Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands
Keywords: SARS-CoV-2, PET-CT imaging, lungs, inflammation, primates
Summary of Study: Vaccine candidate involving a valuable radiotracer to visualize SARS-CoV-2-associated pulmonary inflammation
References: PMID: 35660200 PMCID: PMC9148436 DOI: 10.1016/j.nucmedbio.2022.05.002
Contact Info: Marieke A Stammes: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0969805122020509?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre (BPRC), Rijswijk, Netherlands; Department of Radiology and Nuclear Medicine, Tracer Center Amsterdam (TCA), Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands
Keywords: SARS-CoV-2, PET-CT imaging, lungs, inflammation, primates
Summary of Study: Vaccine candidate involving a valuable radiotracer to visualize SARS-CoV-2-associated pulmonary inflammation
References: PMID: 35660200 PMCID: PMC9148436 DOI: 10.1016/j.nucmedbio.2022.05.002
Contact Info: Marieke A Stammes: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0969805122020509?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2022
Study Type/Review:
NPRC/Institute: Defence Science and Technology Laboratory; United Kingdom Health and Security Agency
Keywords: SARS-CoV-2, aerosolized virus, pathology, immune response, primates
Summary of Study: Following COVID-19 exposure, marmosets did not develop clinical signs other than a disruption to the diurnal temperature rhythm. This may be due to an innate immunological response, which included an increase in neutrophils and monocytes and a reduction in T-cells.
References: PMID: 35891560 / doi: 10.3390/v14071580
Contact Info: Rachel Ireland: [email protected]
URL: https://www.mdpi.com/1999-4915/14/7/1580
NHP Species: marmosets
Year Published: 2022
Study Type/Review:
NPRC/Institute: Defence Science and Technology Laboratory; United Kingdom Health and Security Agency
Keywords: SARS-CoV-2, aerosolized virus, pathology, immune response, primates
Summary of Study: Following COVID-19 exposure, marmosets did not develop clinical signs other than a disruption to the diurnal temperature rhythm. This may be due to an innate immunological response, which included an increase in neutrophils and monocytes and a reduction in T-cells.
References: PMID: 35891560 / doi: 10.3390/v14071580
Contact Info: Rachel Ireland: [email protected]
URL: https://www.mdpi.com/1999-4915/14/7/1580
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Veterinary and Animal Sciences, Pakistan
Keywords: SARS-CoV-2, iodine complexes, treatment, primates
Summary of Study: Iodine complexes have antiviral activity and help to clear coronavirus from monkeys, and Renessans with iodine complexes and ascorbic acid may provide an additive option for treatment.
References: PMID: 36143459; doi: 10.3390/life12091424
Contact Info: Tahir Yaqub: [email protected]
URL: https://www.mdpi.com/2075-1729/12/9/1424
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Veterinary and Animal Sciences, Pakistan
Keywords: SARS-CoV-2, iodine complexes, treatment, primates
Summary of Study: Iodine complexes have antiviral activity and help to clear coronavirus from monkeys, and Renessans with iodine complexes and ascorbic acid may provide an additive option for treatment.
References: PMID: 36143459; doi: 10.3390/life12091424
Contact Info: Tahir Yaqub: [email protected]
URL: https://www.mdpi.com/2075-1729/12/9/1424
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Duke University School of Medicine, Durham, NC; California National Primate Research Center; others.
Keywords: SARS-CoV-2, age-dependent responses, immune response, pathology, primates
Summary of Study: Age-dependent responses to SARS-CoV-2 in dam/infant pairs
References: doi: 10.4049/immunohorizons.2200075
Contact Info: Maria Blasi: [email protected]
URL: https://journals.aai.org/immunohorizons/article/6/12/851/237621/Dam-Infant-Rhes…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Duke University School of Medicine, Durham, NC; California National Primate Research Center; others.
Keywords: SARS-CoV-2, age-dependent responses, immune response, pathology, primates
Summary of Study: Age-dependent responses to SARS-CoV-2 in dam/infant pairs
References: doi: 10.4049/immunohorizons.2200075
Contact Info: Maria Blasi: [email protected]
URL: https://journals.aai.org/immunohorizons/article/6/12/851/237621/Dam-Infant-Rhes…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: prevention
NPRC/Institute: AstraZeneca; BIOQUAL; Vanderbilt University; USAMRIID
Keywords: SARS-CoV-2, monoclonal antibody combination, AZD7442,virus protection, humans, primates
Summary of Study: AZD7442, a monoclonal antibody comprised of AZD8895 and AZD1061, demonstrated potent in vitro neutralization against SARS-CoV-2 VOCs, in vivo efficacy in both prevention and treatment settings of SARS-CoV-2 infection in NHPs, and extended half-life in NHPs and healthy adult participants.
References: PMID: 35076282 / doi: 10.1126/scitranslmed.abl8124
Contact Info: Mark Esser: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abl8124?url_ver=Z39.88-2003&rf…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: prevention
NPRC/Institute: AstraZeneca; BIOQUAL; Vanderbilt University; USAMRIID
Keywords: SARS-CoV-2, monoclonal antibody combination, AZD7442,virus protection, humans, primates
Summary of Study: AZD7442, a monoclonal antibody comprised of AZD8895 and AZD1061, demonstrated potent in vitro neutralization against SARS-CoV-2 VOCs, in vivo efficacy in both prevention and treatment settings of SARS-CoV-2 infection in NHPs, and extended half-life in NHPs and healthy adult participants.
References: PMID: 35076282 / doi: 10.1126/scitranslmed.abl8124
Contact Info: Mark Esser: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abl8124?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Northwestern University; Tulane National Primate Research Center; NIAID; Sanford Burnham Prebys Medical Discovery Institute; Bioqual; New Iberia Research Center
Keywords: SARS-CoV-2, antibody-based in vivo probe system, lungs, primates
Summary of Study: Results provide proof of concept for the use of in vivo antibody-based probes to study SARS-CoV-2 infection dynamics in rhesus macaques.
References: PMID: 35003140 / doi: 10.3389/fimmu.2021.810047
Contact Info: Thomas Hope: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.810047/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Northwestern University; Tulane National Primate Research Center; NIAID; Sanford Burnham Prebys Medical Discovery Institute; Bioqual; New Iberia Research Center
Keywords: SARS-CoV-2, antibody-based in vivo probe system, lungs, primates
Summary of Study: Results provide proof of concept for the use of in vivo antibody-based probes to study SARS-CoV-2 infection dynamics in rhesus macaques.
References: PMID: 35003140 / doi: 10.3389/fimmu.2021.810047
Contact Info: Thomas Hope: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.810047/full
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Ragon Institution of MGH, MIT, and Harvard; Bioqual; Washington University School of Medicine; Emory School of Medicine, Tufts University Cummings School of Veterinary Medicine
Keywords: SARS-CoV-2, mRNA-based BNT162b2 vaccine, virus variants, immune response, primates
Summary of Study: BNT162b2 and Ad26.COV2.S provided robust protection against high-dose challenge with the SARS-CoV-2 Omicron variant in macaques. Protection against this highly mutated SARS-CoV-2 variant correlated with both humoral and cellular immune responses.
References: PMID: 35169798 / doi: 10.1101/2022.02.06.479285
Contact Info: Dan Barouch: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.02.06.479285v1
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Ragon Institution of MGH, MIT, and Harvard; Bioqual; Washington University School of Medicine; Emory School of Medicine, Tufts University Cummings School of Veterinary Medicine
Keywords: SARS-CoV-2, mRNA-based BNT162b2 vaccine, virus variants, immune response, primates
Summary of Study: BNT162b2 and Ad26.COV2.S provided robust protection against high-dose challenge with the SARS-CoV-2 Omicron variant in macaques. Protection against this highly mutated SARS-CoV-2 variant correlated with both humoral and cellular immune responses.
References: PMID: 35169798 / doi: 10.1101/2022.02.06.479285
Contact Info: Dan Barouch: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.02.06.479285v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; Yerkes National Primate Research Center; Emory School of Medicine; Bioqual; Modernal; Harvard T.H. Chan School of Public Health
Keywords: SARS-CoV-2, vaccination, mRNA-1273 or mRNA-Omicron boost, pathology, primates
Summary of Study: Boosting with homologous mRNA-1273 or mRNA-Omicron leads to comparable and significant increases in neutralizing antibody responses against all VOC, including Omicron.
References: PMID: 35447072 / doi: 10.1016/j.cell.2022.03.038
Contact Info: Daniel Douek: [email protected]; Robert Seder: [email protected]
URL: https://www.cell.com/cell/fulltext/S0092-8674(22)00388-9?_returnURL=https%3A//l…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; Yerkes National Primate Research Center; Emory School of Medicine; Bioqual; Modernal; Harvard T.H. Chan School of Public Health
Keywords: SARS-CoV-2, vaccination, mRNA-1273 or mRNA-Omicron boost, pathology, primates
Summary of Study: Boosting with homologous mRNA-1273 or mRNA-Omicron leads to comparable and significant increases in neutralizing antibody responses against all VOC, including Omicron.
References: PMID: 35447072 / doi: 10.1016/j.cell.2022.03.038
Contact Info: Daniel Douek: [email protected]; Robert Seder: [email protected]
URL: https://www.cell.com/cell/fulltext/S0092-8674(22)00388-9?_returnURL=https%3A//l…
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2022
Study Type/Review:
NPRC/Institute: Universidade Federal Rural do Rio de Janeiro; Universidade Federal do Mato Grosso; Universidade Federal do Parana
Keywords: SARS-CoV-2, natural infections, free-ranging animals, pathology, primates
Summary of Study: Free-ranging non-human primates are potential hosts for natural SARS-CoV-2 infection.
References: PMID: 35577455 / doi: 10.1016/j.jcpa.2022.03.005
Contact Info: Valeria Dutra: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0021997522000433?via%3Dihub=
NHP Species: marmosets
Year Published: 2022
Study Type/Review:
NPRC/Institute: Universidade Federal Rural do Rio de Janeiro; Universidade Federal do Mato Grosso; Universidade Federal do Parana
Keywords: SARS-CoV-2, natural infections, free-ranging animals, pathology, primates
Summary of Study: Free-ranging non-human primates are potential hosts for natural SARS-CoV-2 infection.
References: PMID: 35577455 / doi: 10.1016/j.jcpa.2022.03.005
Contact Info: Valeria Dutra: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0021997522000433?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shionogi & Co., Ltd.; Department of Pathology and Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan
Keywords: SARS-CoV-2, recombinant S-protein vaccine S-268019-b, immune response, primates
Summary of Study: Immunogenicity and protective efficacy of SARS-CoV-2 recombinant S-protein vaccine S-268019-b in cynomolgus monkeys
References: PMID: 35691872 PMCID: PMC9167832 DOI: 10.1016/j.vaccine.22.05.081
Contact Info: Hideki Hasegawa: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22007186?via%3Dihub=
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shionogi & Co., Ltd.; Department of Pathology and Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan
Keywords: SARS-CoV-2, recombinant S-protein vaccine S-268019-b, immune response, primates
Summary of Study: Immunogenicity and protective efficacy of SARS-CoV-2 recombinant S-protein vaccine S-268019-b in cynomolgus monkeys
References: PMID: 35691872 PMCID: PMC9167832 DOI: 10.1016/j.vaccine.22.05.081
Contact Info: Hideki Hasegawa: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22007186?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: ReNAP Therapeutics; Mashhad Medical Technologies Science Park; Mashhad University of Medical Sciences; Alzahra University; Tehran University of Medical Sciences; Shahid Beheshti University of Medical Sciences;
Keywords: SARS-CoV-2, mRNA-vaccine, COReNAPCIN®, immune response, mice, primates
Summary of Study: COReNAPCIN is a nucleoside modified mRNA-based vaccine that creates a strong humoral response and protects from symptomatic SARS-CoV-2 infection and clinical damage, thus making it a potent vaccine candidate.
References: PMID: 36056015 / doi: 10.1038/s41541-022-00528-3
Contact Info: Somaye Dehghanizadeh: [email protected]
URL: https://www.nature.com/articles/s41541-022-00528-3
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: ReNAP Therapeutics; Mashhad Medical Technologies Science Park; Mashhad University of Medical Sciences; Alzahra University; Tehran University of Medical Sciences; Shahid Beheshti University of Medical Sciences;
Keywords: SARS-CoV-2, mRNA-vaccine, COReNAPCIN®, immune response, mice, primates
Summary of Study: COReNAPCIN is a nucleoside modified mRNA-based vaccine that creates a strong humoral response and protects from symptomatic SARS-CoV-2 infection and clinical damage, thus making it a potent vaccine candidate.
References: PMID: 36056015 / doi: 10.1038/s41541-022-00528-3
Contact Info: Somaye Dehghanizadeh: [email protected]
URL: https://www.nature.com/articles/s41541-022-00528-3
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Department of Biotechnology, Indian Institute of Technology Hyderabad, Kandi India
Keywords: SARS-CoV-2, virus variants, geographical distribution, genome sequencing, several animal species, primates
Summary of Study: Mutations and evolution of seven distinct clades in non?human hosts
References: doi: 10.1111/zph.12971
Contact Info: Thenmalarchelvi Rathinavelan: [email protected]
URL: https://onlinelibrary.wiley.com/doi/full/10.1111/zph.12971
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Department of Biotechnology, Indian Institute of Technology Hyderabad, Kandi India
Keywords: SARS-CoV-2, virus variants, geographical distribution, genome sequencing, several animal species, primates
Summary of Study: Mutations and evolution of seven distinct clades in non?human hosts
References: doi: 10.1111/zph.12971
Contact Info: Thenmalarchelvi Rathinavelan: [email protected]
URL: https://onlinelibrary.wiley.com/doi/full/10.1111/zph.12971
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Keio University School of Medicine, Tokyo, Japan; RIKEN Center for Integrative Medical Sciences, Infectious Diseases Research unit, Kanagawa, Japan, numerous others.
Keywords: SARS-CoV-2, therapeutic neutralizing antibodies, virus variants, immune response, hamsters, primates
Summary of Study: Potent SARS-CoV-2 neutralizing antibodies with therapeutic effects
References: doi: 10.1016/j.isci.2022.105596
Contact Info: Masaru Takeshita: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2589004222018685?via%3Dihub=
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Keio University School of Medicine, Tokyo, Japan; RIKEN Center for Integrative Medical Sciences, Infectious Diseases Research unit, Kanagawa, Japan, numerous others.
Keywords: SARS-CoV-2, therapeutic neutralizing antibodies, virus variants, immune response, hamsters, primates
Summary of Study: Potent SARS-CoV-2 neutralizing antibodies with therapeutic effects
References: doi: 10.1016/j.isci.2022.105596
Contact Info: Masaru Takeshita: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2589004222018685?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: MIT; Broad Institute of MIT and Harvard; Ragan Institute of MGH, MIT, and Harvard; University of Duisburg-Essen; Space Exploration Technologies Corp.; Harvard University; Vanderbilt University Medical Center; Northwestern University Feinberg School of Medicine; University of Bonn; Howard Hughes Medical Institute; Massachusetts Consortium on Pathogen Readiness; Harvard Medical School; Brigham and Womoen's Hospital; Harvard Humanitarian Initiative
Keywords: SARS-CoV-2, immune biomarkers, reinfection, immune response, primates
Summary of Study: A specific set of SARS-CoV-2-specific humoral features, including spike RBD-specific IgG1 titers, nucleocapsid-specific IgG3 titers, and anti-spike RBD FcyR2A binding activity, were identified as robust biomarkers of reinfection that translate across species. When reinfection cannot be confirmed by viral sequence, changes in SARS-CoV-2 humoral immune responses may offer inexpensive, reliable, and effective measures to track reinfection.
References: PMID: 35073738 / doi: 10.1128/mbio.02141-21
Contact Info: Douglas Lauffenburger: [email protected]; Galit Alter: [email protected]
URL: https://journals.asm.org/doi/full/10.1128/mbio.02141-21?rfr_dat=cr_pub%20%200pu…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: MIT; Broad Institute of MIT and Harvard; Ragan Institute of MGH, MIT, and Harvard; University of Duisburg-Essen; Space Exploration Technologies Corp.; Harvard University; Vanderbilt University Medical Center; Northwestern University Feinberg School of Medicine; University of Bonn; Howard Hughes Medical Institute; Massachusetts Consortium on Pathogen Readiness; Harvard Medical School; Brigham and Womoen's Hospital; Harvard Humanitarian Initiative
Keywords: SARS-CoV-2, immune biomarkers, reinfection, immune response, primates
Summary of Study: A specific set of SARS-CoV-2-specific humoral features, including spike RBD-specific IgG1 titers, nucleocapsid-specific IgG3 titers, and anti-spike RBD FcyR2A binding activity, were identified as robust biomarkers of reinfection that translate across species. When reinfection cannot be confirmed by viral sequence, changes in SARS-CoV-2 humoral immune responses may offer inexpensive, reliable, and effective measures to track reinfection.
References: PMID: 35073738 / doi: 10.1128/mbio.02141-21
Contact Info: Douglas Lauffenburger: [email protected]; Galit Alter: [email protected]
URL: https://journals.asm.org/doi/full/10.1128/mbio.02141-21?rfr_dat=cr_pub%20%200pu…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; China Agricultural University; Capital Medical University; University of Science & Technology of China; Chinese Academy of Medical Sciences and Peking Union Medical College; Chinese Center for Disease Control and Prevention
Keywords: SARS-CoV-2, human neutralizing antibodies, virus variants, mice, primates
Summary of Study: bsAB15 was developed and shown to efficiently neutralize all single-mAb escape mutants. This bsAb is a feasible and effective strategy to treat and prevent severe COVID-19.
References: PMID: 35228696 / doi: 10.1038/s41590-022-01138-w
Contact Info: Yan Wu: [email protected]; Feng Gao: [email protected]
URL: https://www.nature.com/articles/s41590-022-01138-w
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; China Agricultural University; Capital Medical University; University of Science & Technology of China; Chinese Academy of Medical Sciences and Peking Union Medical College; Chinese Center for Disease Control and Prevention
Keywords: SARS-CoV-2, human neutralizing antibodies, virus variants, mice, primates
Summary of Study: bsAB15 was developed and shown to efficiently neutralize all single-mAb escape mutants. This bsAb is a feasible and effective strategy to treat and prevent severe COVID-19.
References: PMID: 35228696 / doi: 10.1038/s41590-022-01138-w
Contact Info: Yan Wu: [email protected]; Feng Gao: [email protected]
URL: https://www.nature.com/articles/s41590-022-01138-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; University of California, San Diego; University of Cape Town, Observatory, South Africa
Keywords: SARS-CoV-2, mild infection, pathology, immune response, primates
Summary of Study: SARS-CoV-2 replication wanes in the lungs, as well as the nasal and oral mucosa, of rhesus macaques before antigen-specific effector T cells arrive at those sites, suggesting that innate immunity efficiently restricts viral replication during mild COVID-19.
References: PMID: 35271298 / doi: 10.1126/sciimmunol.abo0535
Contact Info: Daniel Barber: [email protected]
URL: https://www.science.org/doi/full/10.1126/sciimmunol.abo0535?rfr_dat=cr_pub%20%2…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; University of California, San Diego; University of Cape Town, Observatory, South Africa
Keywords: SARS-CoV-2, mild infection, pathology, immune response, primates
Summary of Study: SARS-CoV-2 replication wanes in the lungs, as well as the nasal and oral mucosa, of rhesus macaques before antigen-specific effector T cells arrive at those sites, suggesting that innate immunity efficiently restricts viral replication during mild COVID-19.
References: PMID: 35271298 / doi: 10.1126/sciimmunol.abo0535
Contact Info: Daniel Barber: [email protected]
URL: https://www.science.org/doi/full/10.1126/sciimmunol.abo0535?rfr_dat=cr_pub%20%2…
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine; Tulane National Primate Research Center
Keywords: SARS-CoV-2, neuropathogenesis, primates
Summary of Study: Substantial pathological changes in brains of SARS-CoV-2 infected NHPs are compatible with autopsy and imaging reports of infected human subjects.
References: PMID: 35365631 / doi: 10.1038/s41467-022-29440-z
Contact Info: Tracy Fischer: [email protected]
URL: https://www.nature.com/articles/s41467-022-29440-z
NHP Species: african green monkeys, rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine; Tulane National Primate Research Center
Keywords: SARS-CoV-2, neuropathogenesis, primates
Summary of Study: Substantial pathological changes in brains of SARS-CoV-2 infected NHPs are compatible with autopsy and imaging reports of infected human subjects.
References: PMID: 35365631 / doi: 10.1038/s41467-022-29440-z
Contact Info: Tracy Fischer: [email protected]
URL: https://www.nature.com/articles/s41467-022-29440-z
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Center for Genetic Engineering and Biotechnology, CIGB, Ave. 31 E/158 y 190, Havana 10600, Cuba
Keywords: SARS-CoV-2, chimeric antigen vaccine, immune response, mice, primates
Summary of Study: Fusion of SARS-CoV-2 receptor binding domain with the extracellular domain of human CD154 is a promising vaccine candidate
References: PMID: 35746505 PMCID: PMC9228316 DOI: 10.3390/vaccines10060897
Contact Info: Yamila Carpio and Mario Pablo Estrada: [email protected]; [email protected]
URL: https://www.mdpi.com/2076-393X/10/6/897
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Center for Genetic Engineering and Biotechnology, CIGB, Ave. 31 E/158 y 190, Havana 10600, Cuba
Keywords: SARS-CoV-2, chimeric antigen vaccine, immune response, mice, primates
Summary of Study: Fusion of SARS-CoV-2 receptor binding domain with the extracellular domain of human CD154 is a promising vaccine candidate
References: PMID: 35746505 PMCID: PMC9228316 DOI: 10.3390/vaccines10060897
Contact Info: Yamila Carpio and Mario Pablo Estrada: [email protected]; [email protected]
URL: https://www.mdpi.com/2076-393X/10/6/897
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Meissa Vaccines Inc; Bill & Melinda Gates Foundation; BIOQUAL Inc; Butler University; Vanderbilt University School of Medicine; University of Texas Medical Branch
Keywords: SARS-CoV-2, attenuated recombinant vaccine, immune response, primates
Summary of Study: A live, attenuated, recombinant human respiratory virus that expresses a chimeric SARS-CoV-2 spike protected against challenge and induced immunoglobulin and neutralizing antibodies.
References: PMID: 35906244 / doi: 10.1038/s41541-022-00509-6
Contact Info: Mariana F. Tioni: [email protected]
URL: https://www.nature.com/articles/s41541-022-00509-6
NHP Species: marmosets
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Meissa Vaccines Inc; Bill & Melinda Gates Foundation; BIOQUAL Inc; Butler University; Vanderbilt University School of Medicine; University of Texas Medical Branch
Keywords: SARS-CoV-2, attenuated recombinant vaccine, immune response, primates
Summary of Study: A live, attenuated, recombinant human respiratory virus that expresses a chimeric SARS-CoV-2 spike protected against challenge and induced immunoglobulin and neutralizing antibodies.
References: PMID: 35906244 / doi: 10.1038/s41541-022-00509-6
Contact Info: Mariana F. Tioni: [email protected]
URL: https://www.nature.com/articles/s41541-022-00509-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: Gujarat Biotechnology Research Centre (GBRC), India; Kamdhenu University, Gujarat, India; University of California Santa Barbara, Santa Barbara, CA.
Keywords: SARS-CoV-2, surveillance, RT-PCR, several animal species, primates
Summary of Study: Highlights transmission of SARS-CoV-2 infection from human to animals and suggests being watchful for zoonosis.
References: doi: 10.3390/ijerph192114391
Contact Info: Arunkumar Patel: [email protected]
URL: https://www.mdpi.com/1660-4601/19/21/14391
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: Gujarat Biotechnology Research Centre (GBRC), India; Kamdhenu University, Gujarat, India; University of California Santa Barbara, Santa Barbara, CA.
Keywords: SARS-CoV-2, surveillance, RT-PCR, several animal species, primates
Summary of Study: Highlights transmission of SARS-CoV-2 infection from human to animals and suggests being watchful for zoonosis.
References: doi: 10.3390/ijerph192114391
Contact Info: Arunkumar Patel: [email protected]
URL: https://www.mdpi.com/1660-4601/19/21/14391
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane School of Medicine
Keywords: SARS-CoV-2, aerosol or intra-tracheal/intra-nasal infection, viral load, inflammation, primates
Summary of Study: Cellular mechanisms underlying acute respiratory distress syndrome
References: doi: 10.1038/s42003-022-04310-y
Contact Info: Namita Rout: [email protected]
URL: https://www.nature.com/articles/s42003-022-04310-y
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane School of Medicine
Keywords: SARS-CoV-2, aerosol or intra-tracheal/intra-nasal infection, viral load, inflammation, primates
Summary of Study: Cellular mechanisms underlying acute respiratory distress syndrome
References: doi: 10.1038/s42003-022-04310-y
Contact Info: Namita Rout: [email protected]
URL: https://www.nature.com/articles/s42003-022-04310-y
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shanghai Medical College, Fudan University; Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College; the First Affiliated Hospital of Guangzhou Medical University; Guangzhou Eighth People's Hospital of Guangzhou Medical University; Bio-Island; Graduate School of Peking Union Medical College; NIFDC; Fulgent Pharma LLC
Keywords: SARS-CoV-2, pan-sarbecovirus vaccines, STING agonist CF501, virus variants, immune response, mice, rabbits, primates.
Summary of Study: A pan-sarbecovirus vaccine was designed by using human IgG Fc-conjugated RBD from the original SARS-CoV-2 strain as the vaccine's immunogen and the STING agonist CF501 as the vaccine's adjuvant. This CF501/RBD-Fc vaccine candidate was able to induce extremely potent, durable, and broad-spectrum nAb and T cell responses, as well as protective immunity, suggesting its potential for development as a highly potent and durable pan-sarbecovirus vaccine.
References: PMID: 35046518 / doi: 10.1038/s41422-022-00612-2
Contact Info: Youchun Wang: [email protected]; Yilong Zhang: [email protected]; Jincun Zhao: [email protected]
URL: https://www.nature.com/articles/s41422-022-00612-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shanghai Medical College, Fudan University; Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College; the First Affiliated Hospital of Guangzhou Medical University; Guangzhou Eighth People's Hospital of Guangzhou Medical University; Bio-Island; Graduate School of Peking Union Medical College; NIFDC; Fulgent Pharma LLC
Keywords: SARS-CoV-2, pan-sarbecovirus vaccines, STING agonist CF501, virus variants, immune response, mice, rabbits, primates.
Summary of Study: A pan-sarbecovirus vaccine was designed by using human IgG Fc-conjugated RBD from the original SARS-CoV-2 strain as the vaccine's immunogen and the STING agonist CF501 as the vaccine's adjuvant. This CF501/RBD-Fc vaccine candidate was able to induce extremely potent, durable, and broad-spectrum nAb and T cell responses, as well as protective immunity, suggesting its potential for development as a highly potent and durable pan-sarbecovirus vaccine.
References: PMID: 35046518 / doi: 10.1038/s41422-022-00612-2
Contact Info: Youchun Wang: [email protected]; Yilong Zhang: [email protected]; Jincun Zhao: [email protected]
URL: https://www.nature.com/articles/s41422-022-00612-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Washington; Washington National Primate Research Center; HDT Bio
Keywords: SARS-CoV-2, immunocompromised animals, SIV, RNA vaccine, immunogenicity, primates
Summary of Study: SARS-CoV-2 alphavirus-derived replicon RNA vaccine formulated with a novel Lipid InOrganic Nanoparticle (LION) emulsion (repRNA-CoV2S) induced robust cellular and humoral immune responses after a single immunization in immunocompromised SIV-infected animals as a highly relevant model of untreated HIV infection in humans.
References: PMID: 34992610 / doi: 10.3389/fimmu.2021.800723
Contact Info: Deborah Fuller: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.800723/full
NHP Species: pigtail macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Washington; Washington National Primate Research Center; HDT Bio
Keywords: SARS-CoV-2, immunocompromised animals, SIV, RNA vaccine, immunogenicity, primates
Summary of Study: SARS-CoV-2 alphavirus-derived replicon RNA vaccine formulated with a novel Lipid InOrganic Nanoparticle (LION) emulsion (repRNA-CoV2S) induced robust cellular and humoral immune responses after a single immunization in immunocompromised SIV-infected animals as a highly relevant model of untreated HIV infection in humans.
References: PMID: 34992610 / doi: 10.3389/fimmu.2021.800723
Contact Info: Deborah Fuller: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.800723/full
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: diagnostics
NPRC/Institute: Universite Paris-Saclay, Inserm, CEA; Sorbonne Universite; BioPredictive; Institut Pasteur
Keywords: SARS-CoV-2, blood test, diagnostics, primates
Summary of Study: Results validate the diagnostic and prognostic performances of A1HPV6 in patients infected by SARS-CoV-2, not hospitalized in ICU. These results are reinforced by similar kinetics of A1, HP, and A2M observed in the macaque model.
References: PMID: 35174366 / doi: 10.1016/j.gastha.2021.12.009
Contact Info: Thierry Poynard: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818442/
NHP Species:
Year Published: 2022
Study Type/Review: diagnostics
NPRC/Institute: Universite Paris-Saclay, Inserm, CEA; Sorbonne Universite; BioPredictive; Institut Pasteur
Keywords: SARS-CoV-2, blood test, diagnostics, primates
Summary of Study: Results validate the diagnostic and prognostic performances of A1HPV6 in patients infected by SARS-CoV-2, not hospitalized in ICU. These results are reinforced by similar kinetics of A1, HP, and A2M observed in the macaque model.
References: PMID: 35174366 / doi: 10.1016/j.gastha.2021.12.009
Contact Info: Thierry Poynard: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818442/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: California National Primate Research Center; University of California, Davis; Vitalant Research Institute; University of Colorado School of Medicine; University of California, Irvine; University of California, San Francisco
Keywords: SARS-CoV-2, human convalescent plasma, inflammation, primates
Summary of Study: Administration of CCP had minimal effects on reducing virus replication in the respiratory tract, but it significantly reduced lung inflammation. These data, combined with the results of monoclonal antibody studies, emphasize the need to use products with high titers of neutralizing antibodies, and guide the future development of antibody-based therapies.
References: PMID: 35443018 / doi: 10.1371/journal.ppat.1009925
Contact Info: Koen Van Rompay: [email protected]; Michael Busch: [email protected]; Rachel Reader: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009925
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: California National Primate Research Center; University of California, Davis; Vitalant Research Institute; University of Colorado School of Medicine; University of California, Irvine; University of California, San Francisco
Keywords: SARS-CoV-2, human convalescent plasma, inflammation, primates
Summary of Study: Administration of CCP had minimal effects on reducing virus replication in the respiratory tract, but it significantly reduced lung inflammation. These data, combined with the results of monoclonal antibody studies, emphasize the need to use products with high titers of neutralizing antibodies, and guide the future development of antibody-based therapies.
References: PMID: 35443018 / doi: 10.1371/journal.ppat.1009925
Contact Info: Koen Van Rompay: [email protected]; Michael Busch: [email protected]; Rachel Reader: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009925
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, longitudinal analyses, lungs, intestines, immune response, primates
Summary of Study: Findings indicate an imbalance of immune dynamic in intestinal mucosa during SARS-CoV-2 infection, which may underlie ongoing rectal viral shedding and mild tissue damage.
References: PMID: 35594870 / doi: 10.1016/j.celrep.2022.110864
Contact Info: Zhanlong He: [email protected]; Haijing Shi: [email protected]; Qihan Li: [email protected]; Longing Liu: [email protected]
URL: https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00637-4?_returnURL=htt…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, longitudinal analyses, lungs, intestines, immune response, primates
Summary of Study: Findings indicate an imbalance of immune dynamic in intestinal mucosa during SARS-CoV-2 infection, which may underlie ongoing rectal viral shedding and mild tissue damage.
References: PMID: 35594870 / doi: 10.1016/j.celrep.2022.110864
Contact Info: Zhanlong He: [email protected]; Haijing Shi: [email protected]; Qihan Li: [email protected]; Longing Liu: [email protected]
URL: https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00637-4?_returnURL=htt…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: CAS Key Laboratory of Computational Biology; Shanghai Institute of Nutrition and Health; University of Chinese Academy of Sciences; Chinese Academy of Sciences; Max Planck Institute of Psychiatry, Proteomics and Biomarkers
Keywords: SARS-CoV-2, circadian gene networks, transcriptome, primates
Summary of Study: Many mammalian genes are controlled by a central clock under circadian control, resulting in a rhythmic expression of genes involved in homeostasis. SARS-CoV-2 related genes are also rhythmically expressed, suggesting close interactions with circadian regulators.
References: PMID: 35906476 / doi: 10.1038/s42003-022-03722-0
Contact Info: Guang-Zhong Wang: [email protected]
URL: https://www.nature.com/articles/s42003-022-03722-0
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: CAS Key Laboratory of Computational Biology; Shanghai Institute of Nutrition and Health; University of Chinese Academy of Sciences; Chinese Academy of Sciences; Max Planck Institute of Psychiatry, Proteomics and Biomarkers
Keywords: SARS-CoV-2, circadian gene networks, transcriptome, primates
Summary of Study: Many mammalian genes are controlled by a central clock under circadian control, resulting in a rhythmic expression of genes involved in homeostasis. SARS-CoV-2 related genes are also rhythmically expressed, suggesting close interactions with circadian regulators.
References: PMID: 35906476 / doi: 10.1038/s42003-022-03722-0
Contact Info: Guang-Zhong Wang: [email protected]
URL: https://www.nature.com/articles/s42003-022-03722-0