Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School, Boston, MA, USA; Beth Israel Deaconess Medical Center, Boston, MA, USA, others
Keywords: SARS-CoV-2, immunogenicity and protective efficacy, Ad26.COV2.S vaccine, primates
Summary of Study: Spike protein ferritin nanoparticle vaccine
References: PMID: 37023746 / doi: 10.1016/j.xcrm.2023.101018
Contact Info: Dan Barouch: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379123001283?via%3Dihub=
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School, Boston, MA, USA; Beth Israel Deaconess Medical Center, Boston, MA, USA, others
Keywords: SARS-CoV-2, immunogenicity and protective efficacy, Ad26.COV2.S vaccine, primates
Summary of Study: Spike protein ferritin nanoparticle vaccine
References: PMID: 37023746 / doi: 10.1016/j.xcrm.2023.101018
Contact Info: Dan Barouch: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379123001283?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Center for Genetic Engineering and Biotechnology, Production Division, Havana, Cuba
Keywords: SARS-CoV-2, chimeric antigen, vaccine, immune response, mice, primates
Summary of Study: chimeric antigen, based on nucleocapsid of SARS-CoV-2 fused to the extracellular domain of human CD154 in HEK-293 cells
References: DOI: 10.1371/journal.pone.0288006
Contact Info: Mario Pablo Estrada: [email protected]; Yamila Carpio: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0288006
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Center for Genetic Engineering and Biotechnology, Production Division, Havana, Cuba
Keywords: SARS-CoV-2, chimeric antigen, vaccine, immune response, mice, primates
Summary of Study: chimeric antigen, based on nucleocapsid of SARS-CoV-2 fused to the extracellular domain of human CD154 in HEK-293 cells
References: DOI: 10.1371/journal.pone.0288006
Contact Info: Mario Pablo Estrada: [email protected]; Yamila Carpio: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0288006
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Stanford University, Scripps Research Institute, others
Keywords: SARS-CoV-2, virus variants, vaccine, immune response, primates
Summary of Study: Extremely potent monoclonal antibodies (mAbs) neutralize multiple sarbecoviruses from macaques vaccinated with AS03-adjuvanted monovalent subunit vaccines.
References: doi: 10.1126/scitranslmed.adg7404
Contact Info: Bali Pulendran: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.adg7404
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Stanford University, Scripps Research Institute, others
Keywords: SARS-CoV-2, virus variants, vaccine, immune response, primates
Summary of Study: Extremely potent monoclonal antibodies (mAbs) neutralize multiple sarbecoviruses from macaques vaccinated with AS03-adjuvanted monovalent subunit vaccines.
References: doi: 10.1126/scitranslmed.adg7404
Contact Info: Bali Pulendran: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.adg7404
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, PA; others
Keywords: SARS-CoV-2, tetravalent S1 subunit protein vaccine, immune response, virus variants, primates
Summary of Study: Tetravalent S1 subunit protein vaccination elicits robust humoral and cellular immune responses
References: doi: 10.1101/2023.03.15.532808. Preprint
Contact Info: Christian Apetrei: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.03.15.532808v1
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, PA; others
Keywords: SARS-CoV-2, tetravalent S1 subunit protein vaccine, immune response, virus variants, primates
Summary of Study: Tetravalent S1 subunit protein vaccination elicits robust humoral and cellular immune responses
References: doi: 10.1101/2023.03.15.532808. Preprint
Contact Info: Christian Apetrei: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.03.15.532808v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review: review
NPRC/Institute: Department de Sanitat i Anatomia Animals, Facultat de Veterinària, Campus de la UAB, Bellaterra, Spain; Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.; others
Keywords: SARS-CoV-2, review, animal models, neurological and neuropsychiatric symptoms, several species, primates
Summary of Study: Animal models to study neurological manifestations
References: DOI: 10.1038/s41684-023-01231-z
Contact Info: Joaquim Segalés: [email protected]
URL: https://www.nature.com/articles/s41684-023-01231-z
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review: review
NPRC/Institute: Department de Sanitat i Anatomia Animals, Facultat de Veterinària, Campus de la UAB, Bellaterra, Spain; Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.; others
Keywords: SARS-CoV-2, review, animal models, neurological and neuropsychiatric symptoms, several species, primates
Summary of Study: Animal models to study neurological manifestations
References: DOI: 10.1038/s41684-023-01231-z
Contact Info: Joaquim Segalés: [email protected]
URL: https://www.nature.com/articles/s41684-023-01231-z
Coronavirus Investigated:
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: National Kunming High-level Biosafety Primate Research Center Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College Yunnan China.; State Key Laboratory of Common Mechanism Research for Major Diseases Department of Biochemistry and Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College Beijing China; others
Keywords: SARS-CoV-2, proteomic and phosphoproteomic profiling, liver, virus variants, primates
Summary of Study: Proteomic and phosphoproteomic profiling of SARS?CoV?2?associated liver injury
References: DOI: 10.1002/mco2.358
Contact Info: Juntao Yang: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458660/
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: National Kunming High-level Biosafety Primate Research Center Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College Yunnan China.; State Key Laboratory of Common Mechanism Research for Major Diseases Department of Biochemistry and Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College Beijing China; others
Keywords: SARS-CoV-2, proteomic and phosphoproteomic profiling, liver, virus variants, primates
Summary of Study: Proteomic and phosphoproteomic profiling of SARS?CoV?2?associated liver injury
References: DOI: 10.1002/mco2.358
Contact Info: Juntao Yang: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458660/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Patronus Biotech Co. Ltd., Yantai, China
Keywords: SARS-CoV-2, RBD virus-like particle vaccine, immune response, virus infection, mice, primates
Summary of Study: RBD virus-like particle vaccine induces cross-variant antibody responses
References: PMID: 37120453 / doi: 10.1038/s41392-023-01425-4
Contact Info: Yuanyuan Li: [email protected]
URL: https://www.nature.com/articles/s41392-023-01425-4
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Patronus Biotech Co. Ltd., Yantai, China
Keywords: SARS-CoV-2, RBD virus-like particle vaccine, immune response, virus infection, mice, primates
Summary of Study: RBD virus-like particle vaccine induces cross-variant antibody responses
References: PMID: 37120453 / doi: 10.1038/s41392-023-01425-4
Contact Info: Yuanyuan Li: [email protected]
URL: https://www.nature.com/articles/s41392-023-01425-4
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Institut Pasteur, Université Paris Cité, National Reference Center for Respiratory Viruses, Paris, France; others
Keywords: SARS-CoV-2, monoclonal antibody treatment, immune response, primates
Summary of Study: Sotrovimab retains activity against SARS-CoV-2 omicron variant BQ.1.1 in a non-human primate model.
References: DOI: 10.1016/j.heliyon.2023.e16664
Contact Info: Roger Le Grand: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2405844023038719?via%3Dihub=
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Institut Pasteur, Université Paris Cité, National Reference Center for Respiratory Viruses, Paris, France; others
Keywords: SARS-CoV-2, monoclonal antibody treatment, immune response, primates
Summary of Study: Sotrovimab retains activity against SARS-CoV-2 omicron variant BQ.1.1 in a non-human primate model.
References: DOI: 10.1016/j.heliyon.2023.e16664
Contact Info: Roger Le Grand: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2405844023038719?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Vaxine Pty Ltd., Warradale, Australia; Flinders University, Bedford Park, Australia; others
Keywords: SARS-CoV-2, spike protein, adjuvanted vaccine, immune response, primates
Summary of Study: Advax-CpG55.2™ adjuvanted recombinant spike protein vaccine protects cynomolgus macaques from a homologous SARS-CoV-2 virus challenge.
References: DOI: 10.1016/j.vaccine.2023.06.063
Contact Info: Nikolai Petrovsky: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X2300748X?via%3Dihub=
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Vaxine Pty Ltd., Warradale, Australia; Flinders University, Bedford Park, Australia; others
Keywords: SARS-CoV-2, spike protein, adjuvanted vaccine, immune response, primates
Summary of Study: Advax-CpG55.2™ adjuvanted recombinant spike protein vaccine protects cynomolgus macaques from a homologous SARS-CoV-2 virus challenge.
References: DOI: 10.1016/j.vaccine.2023.06.063
Contact Info: Nikolai Petrovsky: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X2300748X?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: National Institutes of Health, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
Keywords: SARS-CoV-2, attenuated murine pneumonia virus vector, vaccine immune response, primates
Summary of Study: Mucosal prime-boost immunization with live murine pneumonia virus-vectored vaccine
References: DOI: 10.21203/rs.3.rs-3278289/v1
Contact Info: Ursula Buchholz: [email protected]
URL: https://www.researchsquare.com/article/rs-3278289/v1
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: National Institutes of Health, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
Keywords: SARS-CoV-2, attenuated murine pneumonia virus vector, vaccine immune response, primates
Summary of Study: Mucosal prime-boost immunization with live murine pneumonia virus-vectored vaccine
References: DOI: 10.21203/rs.3.rs-3278289/v1
Contact Info: Ursula Buchholz: [email protected]
URL: https://www.researchsquare.com/article/rs-3278289/v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Dhirubhai Ambani Life Sciences Centre, Reliance Life Sciences Pvt. Ltd., Rabale, Navi Mubai, India
Keywords: SARS-CoV-2, vaccine, dual receptor binding domain, immune response, safety, several species, primates
Summary of Study: Safety, immunogenicity and efficacy of Relcovax®
References: DOI: 10.1016/j.vaccine.2023.10.006
Contact Info: R.L. Ramnath: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23011763?via%3Dihub=
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Dhirubhai Ambani Life Sciences Centre, Reliance Life Sciences Pvt. Ltd., Rabale, Navi Mubai, India
Keywords: SARS-CoV-2, vaccine, dual receptor binding domain, immune response, safety, several species, primates
Summary of Study: Safety, immunogenicity and efficacy of Relcovax®
References: DOI: 10.1016/j.vaccine.2023.10.006
Contact Info: R.L. Ramnath: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23011763?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA; University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania, USA; others
Keywords: SARS-CoV-2, tetravalent vaccine, adjuvant, immune response, primates
Summary of Study: Tetravalent SARS-CoV-2 S1 subunit protein vaccination
References: DOI: 10.1128/mbio.02070-23
Contact Info: Andrea Gambotto: [email protected]
URL: https://journals.asm.org/doi/full/10.1128/mbio.02070-23?rfr_dat=cr_pub%20%200pu…
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA; University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania, USA; others
Keywords: SARS-CoV-2, tetravalent vaccine, adjuvant, immune response, primates
Summary of Study: Tetravalent SARS-CoV-2 S1 subunit protein vaccination
References: DOI: 10.1128/mbio.02070-23
Contact Info: Andrea Gambotto: [email protected]
URL: https://journals.asm.org/doi/full/10.1128/mbio.02070-23?rfr_dat=cr_pub%20%200pu…
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing, China, many others
Keywords: SARS-CoV-2, aerosol immunization, immune response, virus variants, primates
Summary of Study: Inhaled vaccine for single-dose dry powder aerosol immunization
References: PMID: 38093012 DOI: 10.1038/s41586-023-06809-8
Contact Info: Wei Wei: [email protected]
URL: https://www.nature.com/articles/s41586-023-06809-8
NHP Species: cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing, China, many others
Keywords: SARS-CoV-2, aerosol immunization, immune response, virus variants, primates
Summary of Study: Inhaled vaccine for single-dose dry powder aerosol immunization
References: PMID: 38093012 DOI: 10.1038/s41586-023-06809-8
Contact Info: Wei Wei: [email protected]
URL: https://www.nature.com/articles/s41586-023-06809-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: National Institutes of Health, Islamabad, Pakistan; Department of Pathology and Laboratory Medicine, University of California, Davis, Davis, California, USA; others
Keywords: SARS-CoV-2, mRNA vaccine, immune response, humans, primates
Summary of Study: Immune responses in nonhuman primates and humans immunized with COVID-19 vaccines
References: DOI: 10.1371/journal.pone.0287377
Contact Info: Imran H. Khan: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0287377
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: National Institutes of Health, Islamabad, Pakistan; Department of Pathology and Laboratory Medicine, University of California, Davis, Davis, California, USA; others
Keywords: SARS-CoV-2, mRNA vaccine, immune response, humans, primates
Summary of Study: Immune responses in nonhuman primates and humans immunized with COVID-19 vaccines
References: DOI: 10.1371/journal.pone.0287377
Contact Info: Imran H. Khan: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0287377
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China; others
Keywords: SARS-CoV-2, transcriptome analysis, virus variants, subgenomic RNA, primates
Summary of Study: Differential Transcriptomic Landscapes of SARS-CoV-2 Variants in Multiple Organs
References: doi:10.1016/j.gpb.2023.06.002
Contact Info: Xiaozhong Peng: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1672022923000955?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China; others
Keywords: SARS-CoV-2, transcriptome analysis, virus variants, subgenomic RNA, primates
Summary of Study: Differential Transcriptomic Landscapes of SARS-CoV-2 Variants in Multiple Organs
References: doi:10.1016/j.gpb.2023.06.002
Contact Info: Xiaozhong Peng: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1672022923000955?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Spain; others
Keywords: SARS-CoV-2, PHH-1V, vaccine, immune response, airways, primates
Summary of Study: Preclinical evaluation of PHH-1V vaccine candidate
References: DOI: 10.1016/j.isci.2023.107224
Contact Info: Antoni Prenafeta: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2589004223013019?via%3Dihub=
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Spain; others
Keywords: SARS-CoV-2, PHH-1V, vaccine, immune response, airways, primates
Summary of Study: Preclinical evaluation of PHH-1V vaccine candidate
References: DOI: 10.1016/j.isci.2023.107224
Contact Info: Antoni Prenafeta: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2589004223013019?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: School of Pharmacy, University of Chinese Academy of Sciences, Beijing, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China, others
Keywords: SARS-CoV-2, nelfinavir, prophylactics, virus protection, humans, primates
Summary of Study: Nelfinavir preventive and therapeutic effects
References: PMID: 37095086 / doi: 10.1038/s41392-023-01429-0
Contact Info: Weiliang Zhu: [email protected]
URL: https://www.nature.com/articles/s41392-023-01429-0
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: School of Pharmacy, University of Chinese Academy of Sciences, Beijing, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China, others
Keywords: SARS-CoV-2, nelfinavir, prophylactics, virus protection, humans, primates
Summary of Study: Nelfinavir preventive and therapeutic effects
References: PMID: 37095086 / doi: 10.1038/s41392-023-01429-0
Contact Info: Weiliang Zhu: [email protected]
URL: https://www.nature.com/articles/s41392-023-01429-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Gwanak-gu, Seoul, 08826, Republic of Korea; others
Keywords: SARS-CoV-2, pulmonary lesions, histopathology, primates
Summary of Study: Histopathological pulmonary lesions in SARS-CoV-2
References: PMID: 38007889 DOI: 10.1016/j.jcpa.2023.10.008
Contact Info: Jae-Hak Park: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0021997523002967?via%3Dihub=
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Gwanak-gu, Seoul, 08826, Republic of Korea; others
Keywords: SARS-CoV-2, pulmonary lesions, histopathology, primates
Summary of Study: Histopathological pulmonary lesions in SARS-CoV-2
References: PMID: 38007889 DOI: 10.1016/j.jcpa.2023.10.008
Contact Info: Jae-Hak Park: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0021997523002967?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: State Key Laboratory of Medical Molecular Biology Department of Molecular Biology and Biochemistry Institute of Basic Medical Sciences Medical Primate Research Center Neuroscience Center Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical College Beijing China; others
Keywords: SARS-CoV-2, immune response, PBMCs, single?cell sequencing, virus variants, primates
Summary of Study: Single-cell transcriptomic atlas of distinct early immune responses
References: PMID: 38020713 PMCID: PMC10661830 DOI: 10.1002/mco2.432
Contact Info: Xiaozhong Peng: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661830/
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: State Key Laboratory of Medical Molecular Biology Department of Molecular Biology and Biochemistry Institute of Basic Medical Sciences Medical Primate Research Center Neuroscience Center Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical College Beijing China; others
Keywords: SARS-CoV-2, immune response, PBMCs, single?cell sequencing, virus variants, primates
Summary of Study: Single-cell transcriptomic atlas of distinct early immune responses
References: PMID: 38020713 PMCID: PMC10661830 DOI: 10.1002/mco2.432
Contact Info: Xiaozhong Peng: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661830/
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: University of Alabama at Birmingham, University of Florida
Keywords: SARS-CoV-2, sexual dimorphism, transcriptomics, translation, immunogenicity, primates
Summary of Study: Sex differences in brain and susceptibility to COVID-19
References: PMID: 38045237 PMCID: PMC10690328 DOI: 10.21203/rs.3.rs-3422091/v1
Contact Info: Coy Heldermon: [email protected]
URL: https://www.researchsquare.com/article/rs-3422091/v1
NHP Species: cynomolgus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: University of Alabama at Birmingham, University of Florida
Keywords: SARS-CoV-2, sexual dimorphism, transcriptomics, translation, immunogenicity, primates
Summary of Study: Sex differences in brain and susceptibility to COVID-19
References: PMID: 38045237 PMCID: PMC10690328 DOI: 10.21203/rs.3.rs-3422091/v1
Contact Info: Coy Heldermon: [email protected]
URL: https://www.researchsquare.com/article/rs-3422091/v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Tulane National Primate Research Center, Covington, Louisiana; others
Keywords: SARS-CoV-2, SIV-Induced Immunodeficiency, immune response, coinfection, primates
Summary of Study: Impact of SIV-Induced Immunodeficiency on Clinical Manifestation, Immune Response, and Viral Dynamics in SARS-CoV-2 Coinfection
References: bioRxiv.2023 Nov 16:2023.11.15.567132. doi: 10.1101/2023.11.15.567132. Preprint. PMID: 38014096 PMCID: PMC10680717 DOI: 10.1101/2023.11.15.567132
Contact Info: Nicholas Maness: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.11.15.567132v1
NHP Species: pigtail macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Tulane National Primate Research Center, Covington, Louisiana; others
Keywords: SARS-CoV-2, SIV-Induced Immunodeficiency, immune response, coinfection, primates
Summary of Study: Impact of SIV-Induced Immunodeficiency on Clinical Manifestation, Immune Response, and Viral Dynamics in SARS-CoV-2 Coinfection
References: bioRxiv.2023 Nov 16:2023.11.15.567132. doi: 10.1101/2023.11.15.567132. Preprint. PMID: 38014096 PMCID: PMC10680717 DOI: 10.1101/2023.11.15.567132
Contact Info: Nicholas Maness: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.11.15.567132v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; others
Keywords: SARS-CoV-2, Beta-spike-containing boosters, immune response, primates
Summary of Study: Beta-spike-containing boosters induce robust and functional antibody responses
References: PMID: 38007686 DOI: 10.1016/j.celrep.2023.113292
Contact Info: Ryan McNamara: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2211124723013049?via%3Dihub=
NHP Species: rhesus macaques, cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; others
Keywords: SARS-CoV-2, Beta-spike-containing boosters, immune response, primates
Summary of Study: Beta-spike-containing boosters induce robust and functional antibody responses
References: PMID: 38007686 DOI: 10.1016/j.celrep.2023.113292
Contact Info: Ryan McNamara: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2211124723013049?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Tonix Pharmaceuticals; others
Keywords: SARS-CoV-2, vaccine, horsepox virus, spike protein, antibody titer, immunogenicity, primates
Summary of Study: TNX-1800, a live virus recombinant poxvirus vaccine candidate
References: PMID: 38006014 PMCID: PMC10674175 DOI: 10.3390/vaccines11111682
Contact Info: Seth Lederman: seth.lederman@tonix
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674175/pdf/vaccines-11-01682.pdf
NHP Species: african green monkeys, cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Tonix Pharmaceuticals; others
Keywords: SARS-CoV-2, vaccine, horsepox virus, spike protein, antibody titer, immunogenicity, primates
Summary of Study: TNX-1800, a live virus recombinant poxvirus vaccine candidate
References: PMID: 38006014 PMCID: PMC10674175 DOI: 10.3390/vaccines11111682
Contact Info: Seth Lederman: seth.lederman@tonix
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674175/pdf/vaccines-11-01682.pdf
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Emory University School of Medicine; Emory, Oregon and Tulane NPRCs; numerous others
Keywords: SARS-CoV-2, IFN-I, immune response, pathology, primates
Summary of Study: Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation
References: DOI: 10.1126/sciimmunol.adg0033
Contact Info: Mirko Paiardini: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.adg0033
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Emory University School of Medicine; Emory, Oregon and Tulane NPRCs; numerous others
Keywords: SARS-CoV-2, IFN-I, immune response, pathology, primates
Summary of Study: Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation
References: DOI: 10.1126/sciimmunol.adg0033
Contact Info: Mirko Paiardini: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.adg0033
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Vaccine Research Institute, Créteil, France; Université Paris Cité, IAME, Inserm, Paris, France; others
Keywords: SARS-CoV-2, mathematical model, viral dynamic, primates
Summary of Study: Impact of variants of concern on SARS-CoV-2 viral dynamics
References: DOI: 10.1371/journal.pcbi.1010721
Contact Info: Aurélien Marc: [email protected]
URL: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1010721
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Vaccine Research Institute, Créteil, France; Université Paris Cité, IAME, Inserm, Paris, France; others
Keywords: SARS-CoV-2, mathematical model, viral dynamic, primates
Summary of Study: Impact of variants of concern on SARS-CoV-2 viral dynamics
References: DOI: 10.1371/journal.pcbi.1010721
Contact Info: Aurélien Marc: [email protected]
URL: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1010721
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: The First Affiliated Hospital of Jinan University, Guangzhou 510630, China; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA USA
Keywords: SARS-CoV-2, favipiravir, biodistribution and pharmacokinetics, positron emission tomography, mice, primates
Summary of Study: Evaluating Favipiravir in rodents and nonhuman primates (NHP) with positron emission tomography
References: PMID: 37111280 / doi: 10.3390/ph16040524
Contact Info: Steven Liang: [email protected]
URL: https://www.mdpi.com/1424-8247/16/4/524
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: The First Affiliated Hospital of Jinan University, Guangzhou 510630, China; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA USA
Keywords: SARS-CoV-2, favipiravir, biodistribution and pharmacokinetics, positron emission tomography, mice, primates
Summary of Study: Evaluating Favipiravir in rodents and nonhuman primates (NHP) with positron emission tomography
References: PMID: 37111280 / doi: 10.3390/ph16040524
Contact Info: Steven Liang: [email protected]
URL: https://www.mdpi.com/1424-8247/16/4/524
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Chulalongkorn University, Bangkok, Thailand and others
Keywords: SARS-CoV-2, recombinant plant-based RBD vaccine, immunogenicity, efficacy, safety, mice, primates
Summary of Study: Recombinant plant based RBD vaccine formulated with 3M-052-Alum adjuvant
References: PMID: 36963999 / doi: 10.1016/j.vaccine.2023.03.027
Contact Info: Waranyoo Phoolcharoen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003122?via%3Dihub=
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Chulalongkorn University, Bangkok, Thailand and others
Keywords: SARS-CoV-2, recombinant plant-based RBD vaccine, immunogenicity, efficacy, safety, mice, primates
Summary of Study: Recombinant plant based RBD vaccine formulated with 3M-052-Alum adjuvant
References: PMID: 36963999 / doi: 10.1016/j.vaccine.2023.03.027
Contact Info: Waranyoo Phoolcharoen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003122?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Janssen Research and Development, Beerse, Belgium and Janssen Vaccines and Prevention B.V., Leiden, The Netherlands
Keywords: SARS-CoV-2, mechanistic modeling, vaccination, immune response, primates
Summary of Study: Humoral Immunity Following Ad26.COV2.S Vaccination
References: DOI: 10.1124/jpet.123.001591
Contact Info: Anna Dari: [email protected]
URL: https://jpet.aspetjournals.org/content/387/1/121.long
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Janssen Research and Development, Beerse, Belgium and Janssen Vaccines and Prevention B.V., Leiden, The Netherlands
Keywords: SARS-CoV-2, mechanistic modeling, vaccination, immune response, primates
Summary of Study: Humoral Immunity Following Ad26.COV2.S Vaccination
References: DOI: 10.1124/jpet.123.001591
Contact Info: Anna Dari: [email protected]
URL: https://jpet.aspetjournals.org/content/387/1/121.long
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Emory National Primate Research Center, Emory School of Medicine, others
Keywords: SARS-CoV-2, vaccine comparison, immune response, nasopharynx, primates
Summary of Study: Efficacy of mRNA-1273 and Novavax ancestral or BA.1 spike booster vaccines
References: doi: 10.1126/sciimmunol.adg7015
Contact Info: Rama Rao Amara: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.adg7015
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Emory National Primate Research Center, Emory School of Medicine, others
Keywords: SARS-CoV-2, vaccine comparison, immune response, nasopharynx, primates
Summary of Study: Efficacy of mRNA-1273 and Novavax ancestral or BA.1 spike booster vaccines
References: doi: 10.1126/sciimmunol.adg7015
Contact Info: Rama Rao Amara: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.adg7015
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Massachusetts General Hospital, Charlestown, Massachusetts USA; Brigham and Women's Hospital, Boston, Massachusetts, and others
Keywords: SARS-CoV-2, review, brain autopsies, neuropathological findings, humans, animal models, primates
Summary of Study: Review: What Can We Still Learn from Brain Autopsies in COVID-19?
References: PMID: 37023787 / doi: 10.1055/s-0043-1767716
Contact Info: Shibani Mukerji: [email protected]
URL: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-17677…
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Massachusetts General Hospital, Charlestown, Massachusetts USA; Brigham and Women's Hospital, Boston, Massachusetts, and others
Keywords: SARS-CoV-2, review, brain autopsies, neuropathological findings, humans, animal models, primates
Summary of Study: Review: What Can We Still Learn from Brain Autopsies in COVID-19?
References: PMID: 37023787 / doi: 10.1055/s-0043-1767716
Contact Info: Shibani Mukerji: [email protected]
URL: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-17677…
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine, Tulane National Primate Research Center, others
Keywords: SARS-CoV-2, CSF, neuropathology, proteomics, mass-spectrometry, primates
Summary of Study: Cerebrospinal Fluid Protein Markers Indicate Neuro-Damage in SARS-CoV-2-Infected Nonhuman Primates.
References: DOI: 10.1016/j.mcpro.2023.100523
Contact Info: Jia Fan: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981268/
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine, Tulane National Primate Research Center, others
Keywords: SARS-CoV-2, CSF, neuropathology, proteomics, mass-spectrometry, primates
Summary of Study: Cerebrospinal Fluid Protein Markers Indicate Neuro-Damage in SARS-CoV-2-Infected Nonhuman Primates.
References: DOI: 10.1016/j.mcpro.2023.100523
Contact Info: Jia Fan: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981268/
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Virology and Immunology, Graduate School of Medicine, Osaka University, Osaka, 565-0871 Japan, others
Keywords: SARS-CoV-2, vaccine, Spike (S) receptor binding domain, immune response, primates
Summary of Study: saRNA vaccine expressing membrane-anchored RBD elicits broad and durable immunity
References: doi: 10.1038/s41467-023-38457-x
Contact Info: Takuya Yamamoto: [email protected]
URL: https://www.nature.com/articles/s41467-023-38457-x
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Virology and Immunology, Graduate School of Medicine, Osaka University, Osaka, 565-0871 Japan, others
Keywords: SARS-CoV-2, vaccine, Spike (S) receptor binding domain, immune response, primates
Summary of Study: saRNA vaccine expressing membrane-anchored RBD elicits broad and durable immunity
References: doi: 10.1038/s41467-023-38457-x
Contact Info: Takuya Yamamoto: [email protected]
URL: https://www.nature.com/articles/s41467-023-38457-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China; others
Keywords: SARS-CoV-2, pathogenesis, immune response, mice, hamsters, primates
Summary of Study: SARS-CoV-2 Omicron (B.1.1.529) infection in rhesus macaques, hamsters, and BALB/c mice with severe lung histopathological damage.
References: DOI: 10.1002/jmv.28846
Contact Info: Shuaiyao Lu: [email protected]
URL: https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.28846
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China; others
Keywords: SARS-CoV-2, pathogenesis, immune response, mice, hamsters, primates
Summary of Study: SARS-CoV-2 Omicron (B.1.1.529) infection in rhesus macaques, hamsters, and BALB/c mice with severe lung histopathological damage.
References: DOI: 10.1002/jmv.28846
Contact Info: Shuaiyao Lu: [email protected]
URL: https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.28846
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, China; others
Keywords: SARS-CoV-2, inactivated vaccine, immune response, primates
Summary of Study: Preclinical safety evaluation of intradermal SARS-CoV-2 inactivated vaccine (Vero cells) administration in macaques.
References: DOI: 10.1016/j.vaccine.2023.03.033
Contact Info: Qihan Li: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003171?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, China; others
Keywords: SARS-CoV-2, inactivated vaccine, immune response, primates
Summary of Study: Preclinical safety evaluation of intradermal SARS-CoV-2 inactivated vaccine (Vero cells) administration in macaques.
References: DOI: 10.1016/j.vaccine.2023.03.033
Contact Info: Qihan Li: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003171?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea; others
Keywords: SARS-CoV-2, spatial transcriptomic profiling, lungs, virus variants, primates
Summary of Study: Comparative spatial transcriptomic profiling of severe acute respiratory syndrome coronavirus 2 Delta and Omicron variants infections in the lungs of cynomolgus macaques.
References: DOI: 10.1002/jmv.28847
Contact Info: Jung Joo Hong: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/jmv.28847
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea; others
Keywords: SARS-CoV-2, spatial transcriptomic profiling, lungs, virus variants, primates
Summary of Study: Comparative spatial transcriptomic profiling of severe acute respiratory syndrome coronavirus 2 Delta and Omicron variants infections in the lungs of cynomolgus macaques.
References: DOI: 10.1002/jmv.28847
Contact Info: Jung Joo Hong: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/jmv.28847
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: University of South Carolina; Tulane National Primate Research Center
Keywords: SARS-CoV-2, brain, pathology, in situ hybridization, primates
Summary of Study: SARS-CoV-2 RNA Persists in the Central Nervous System despite clinical recovery
References: DOI: 10.1101/2023.08.29.555368
Contact Info: Rosemarie Booze: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491216/
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: University of South Carolina; Tulane National Primate Research Center
Keywords: SARS-CoV-2, brain, pathology, in situ hybridization, primates
Summary of Study: SARS-CoV-2 RNA Persists in the Central Nervous System despite clinical recovery
References: DOI: 10.1101/2023.08.29.555368
Contact Info: Rosemarie Booze: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491216/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; others
Keywords: SARS-CoV-2, mRNA-lipid nanoparticle vaccine candidate, safety, immune response, mice, primate
Summary of Study: Characterization of stability, safety and immunogenicity of the mRNA lipid nanoparticle vaccine Iribovax® against COVID-19 in nonhuman primates.
References: DOI: 10.1016/j.jconrel.2023.06.025
Contact Info: Sina Mozaffari-Jovin: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S016836592300398X?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; others
Keywords: SARS-CoV-2, mRNA-lipid nanoparticle vaccine candidate, safety, immune response, mice, primate
Summary of Study: Characterization of stability, safety and immunogenicity of the mRNA lipid nanoparticle vaccine Iribovax® against COVID-19 in nonhuman primates.
References: DOI: 10.1016/j.jconrel.2023.06.025
Contact Info: Sina Mozaffari-Jovin: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S016836592300398X?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Executive Office, Shanghai BravoBio Co., Ltd., Shanghai, China; BravoVax Co., Ltd., Wuhan, China
Keywords: SARS-CoV-2, adenovirus vaccine, aerosol inhalation, immune response, primates
Summary of Study: Aerosol Inhalation of Chimpanzee Adenovirus Vectors (ChAd68) Expressing Ancestral or Omicron BA.1 Stabilized Pre-Fusion Spike Glycoproteins
References: DOI: 10.3390/vaccines11091427
Contact Info: Ke Wu: [email protected]
URL: https://www.mdpi.com/2076-393X/11/9/1427
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Executive Office, Shanghai BravoBio Co., Ltd., Shanghai, China; BravoVax Co., Ltd., Wuhan, China
Keywords: SARS-CoV-2, adenovirus vaccine, aerosol inhalation, immune response, primates
Summary of Study: Aerosol Inhalation of Chimpanzee Adenovirus Vectors (ChAd68) Expressing Ancestral or Omicron BA.1 Stabilized Pre-Fusion Spike Glycoproteins
References: DOI: 10.3390/vaccines11091427
Contact Info: Ke Wu: [email protected]
URL: https://www.mdpi.com/2076-393X/11/9/1427
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: SingHealth Duke-NUS Global Health Institute, Singapore; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore; others
Keywords: SARS-CoV-2, mast cells, lungs, pathology, mice, primates, humans.
Summary of Study: Mast cell activation in lungs and severe COVID-19
References: DOI: 10.1172/JCI149834
Contact Info: Ashley L. St. John: [email protected]
URL: https://www.jci.org/articles/view/149834
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: SingHealth Duke-NUS Global Health Institute, Singapore; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore; others
Keywords: SARS-CoV-2, mast cells, lungs, pathology, mice, primates, humans.
Summary of Study: Mast cell activation in lungs and severe COVID-19
References: DOI: 10.1172/JCI149834
Contact Info: Ashley L. St. John: [email protected]
URL: https://www.jci.org/articles/view/149834
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Emory University, Emory National Primate Research Center, others
Keywords: SARS-CoV-2, innate immune system, airway inflammation, humans, primates
Summary of Study: TREM2+ and interstitial-like macrophages orchestrate airway inflammation
References: PMID: 37024448 / doi: 10.1038/s41467-023-37425-9
Contact Info: Mirko Paiardini: [email protected]
URL: https://www.nature.com/articles/s41467-023-37425-9
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Emory University, Emory National Primate Research Center, others
Keywords: SARS-CoV-2, innate immune system, airway inflammation, humans, primates
Summary of Study: TREM2+ and interstitial-like macrophages orchestrate airway inflammation
References: PMID: 37024448 / doi: 10.1038/s41467-023-37425-9
Contact Info: Mirko Paiardini: [email protected]
URL: https://www.nature.com/articles/s41467-023-37425-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: NIAID, Bethesda MD; Weizmann Inst. Of Science, Rehovot, Israel; others
Keywords: SARS-CoV-2, in vitro evolution, ACE2 binding affinity, airways, immune response, primates
Summary of Study: RBD-based high affinity ACE2 antagonist limits SARS-CoV-2 replication in upper and lower airways
References: DOI: 10.1101/2023.06.09.544432
Contact Info: Daniel Douek: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.06.09.544432v1
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: NIAID, Bethesda MD; Weizmann Inst. Of Science, Rehovot, Israel; others
Keywords: SARS-CoV-2, in vitro evolution, ACE2 binding affinity, airways, immune response, primates
Summary of Study: RBD-based high affinity ACE2 antagonist limits SARS-CoV-2 replication in upper and lower airways
References: DOI: 10.1101/2023.06.09.544432
Contact Info: Daniel Douek: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.06.09.544432v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: prevention
NPRC/Institute: Graduate School of Medicine and Veterinary Medicine, University of Miyazaki, Miyazaki, 889-2155, Japan; Laboratory of Immunoregulation and Vaccine Research, Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Tsukuba, 305-0843, Japan.; others
Keywords: SARS-CoV-2, ACE2 decoy, immune response, pathology, mice, hamsters, primates
Summary of Study: Inhaled ACE2 decoy confers protection
References: DOI: 10.1126/scitranslmed.adi2623
Contact Info: Atsushi Hoshino: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.adi2623
NHP Species:
Year Published: 2023
Study Type/Review: prevention
NPRC/Institute: Graduate School of Medicine and Veterinary Medicine, University of Miyazaki, Miyazaki, 889-2155, Japan; Laboratory of Immunoregulation and Vaccine Research, Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Tsukuba, 305-0843, Japan.; others
Keywords: SARS-CoV-2, ACE2 decoy, immune response, pathology, mice, hamsters, primates
Summary of Study: Inhaled ACE2 decoy confers protection
References: DOI: 10.1126/scitranslmed.adi2623
Contact Info: Atsushi Hoshino: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.adi2623
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Frederick National Laboratory for Cancer Research, Frederick, MD, USA; others
Keywords: SARS-CoV-2, machine-learning, radiomics, biomarkers, immune response, disease progression, primates
Summary of Study: Novel machine-learning analysis of infection using radiomics and blood biomarkers
References: PMID: 37950044 PMCID: PMC10638262 DOI: 10.1038/s41598-023-46694-9
Contact Info: Jeffrey Solomon: [email protected]
URL: https://www.nature.com/articles/s41598-023-46694-9
NHP Species: cynomolgus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Frederick National Laboratory for Cancer Research, Frederick, MD, USA; others
Keywords: SARS-CoV-2, machine-learning, radiomics, biomarkers, immune response, disease progression, primates
Summary of Study: Novel machine-learning analysis of infection using radiomics and blood biomarkers
References: PMID: 37950044 PMCID: PMC10638262 DOI: 10.1038/s41598-023-46694-9
Contact Info: Jeffrey Solomon: [email protected]
URL: https://www.nature.com/articles/s41598-023-46694-9
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: University of Maryland School of Medicine, Baltimore, MD; others
Keywords: SARS-CoV-2, prefusion-stabilized spike protein, vaccine, immune response, virus variants, primates
Summary of Study: Immunogenicity and protection of a variant nanoparticle vaccine
References: DOI: 10.1038/s41467-022-35606-6
Contact Info: Matthew B. Frieman: [email protected]
URL: https://www.nature.com/articles/s41467-022-35606-6
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: University of Maryland School of Medicine, Baltimore, MD; others
Keywords: SARS-CoV-2, prefusion-stabilized spike protein, vaccine, immune response, virus variants, primates
Summary of Study: Immunogenicity and protection of a variant nanoparticle vaccine
References: DOI: 10.1038/s41467-022-35606-6
Contact Info: Matthew B. Frieman: [email protected]
URL: https://www.nature.com/articles/s41467-022-35606-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Cognitive and Neural Science Program, Department of Psychology, University of South Carolina, Columbia, SC, 29208, USA; others
Keywords: SARS-CoV-2, nervous system, pathophysiology, virus persistence, primates
Summary of Study: Viral persistence in central nervous system despite clinical recovery
References: PMID: 37934362 PMCID: PMC10630293 DOI: 10.1186/s43556-023-00153-z
Contact Info: Rosemarie Booze: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630293/
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Cognitive and Neural Science Program, Department of Psychology, University of South Carolina, Columbia, SC, 29208, USA; others
Keywords: SARS-CoV-2, nervous system, pathophysiology, virus persistence, primates
Summary of Study: Viral persistence in central nervous system despite clinical recovery
References: PMID: 37934362 PMCID: PMC10630293 DOI: 10.1186/s43556-023-00153-z
Contact Info: Rosemarie Booze: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630293/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microbes and Infection, Fudan University, Shanghai, China
Keywords: SARS-CoV-2, fusion inhibitor, IgG-binding peptide, immune response, primates
Summary of Study: IgG Fc-Binding Peptide-Conjugated Pan-CoV Fusion Inhibitor Combined with Neutralizing Antibodies
References: DOI: 10.3390/biom13091283
Contact Info: Shibo Jiang:[email protected]; Shuai Xia: [email protected]
URL: https://www.mdpi.com/2218-273X/13/9/1283
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microbes and Infection, Fudan University, Shanghai, China
Keywords: SARS-CoV-2, fusion inhibitor, IgG-binding peptide, immune response, primates
Summary of Study: IgG Fc-Binding Peptide-Conjugated Pan-CoV Fusion Inhibitor Combined with Neutralizing Antibodies
References: DOI: 10.3390/biom13091283
Contact Info: Shibo Jiang:[email protected]; Shuai Xia: [email protected]
URL: https://www.mdpi.com/2218-273X/13/9/1283
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Federal Medical-Biological Agency of Russia, Moscow, Russia; Saint Petersburg Scientific Research Institute of Vaccines and Serums of the Federal Medical-Biological Agency of Russia; others
Keywords: SARS-CoV-2, nucleocapsid, vaccine, immune response, primates
Summary of Study: Recombinant Nucleocapsid-Based Vaccine Convacell®
References: DOI: 10.3390/vaccines11040874
Contact Info: Sevastyan Rabdano: [email protected]
URL: https://www.mdpi.com/2076-393X/11/4/874
NHP Species: multiple species
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Federal Medical-Biological Agency of Russia, Moscow, Russia; Saint Petersburg Scientific Research Institute of Vaccines and Serums of the Federal Medical-Biological Agency of Russia; others
Keywords: SARS-CoV-2, nucleocapsid, vaccine, immune response, primates
Summary of Study: Recombinant Nucleocapsid-Based Vaccine Convacell®
References: DOI: 10.3390/vaccines11040874
Contact Info: Sevastyan Rabdano: [email protected]
URL: https://www.mdpi.com/2076-393X/11/4/874
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Universitas Airlangga, Surabaya, Indonesia
Keywords: SARS-CoV-2, inactivated vaccine, immune response, primates
Summary of Study: Inactivated SARS-CoV-2 vaccine candidate immunization
References: DOI: 10.1016/j.heliyon.2023.e18039
Contact Info: Fedik Abdul Rantam: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2405844023052477?via%3Dihub=
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Universitas Airlangga, Surabaya, Indonesia
Keywords: SARS-CoV-2, inactivated vaccine, immune response, primates
Summary of Study: Inactivated SARS-CoV-2 vaccine candidate immunization
References: DOI: 10.1016/j.heliyon.2023.e18039
Contact Info: Fedik Abdul Rantam: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2405844023052477?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: University of Kentucky, University of California Irvine, USA
Keywords: SARS-CoV-2, alcohol, lung, scRNA sequencing, flow cytometry, primates
Summary of Study: Chronic alcohol consumption dysregulates innate immune response to SARS-CoV-2 in the lung
References: DOI: 10.1016/j.ebiom.2023.104812
Contact Info: Ilhem Messaoudi: ilhem@[email protected]
URL: https://www.sciencedirect.com/science/article/pii/S235239642300378X?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: University of Kentucky, University of California Irvine, USA
Keywords: SARS-CoV-2, alcohol, lung, scRNA sequencing, flow cytometry, primates
Summary of Study: Chronic alcohol consumption dysregulates innate immune response to SARS-CoV-2 in the lung
References: DOI: 10.1016/j.ebiom.2023.104812
Contact Info: Ilhem Messaoudi: ilhem@[email protected]
URL: https://www.sciencedirect.com/science/article/pii/S235239642300378X?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, China and others
Keywords: SARS-CoV-2, intradermal inactivated vaccine, immune response, virus variants, primates
Summary of Study: Preclinical safety evaluation of Intradermal inactivated vaccine (vero cells) administration
References: PMID: 37003910 / doi: 10.1016/j.vaccine.2023.03.033
Contact Info: Qihan Li: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003171?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, China and others
Keywords: SARS-CoV-2, intradermal inactivated vaccine, immune response, virus variants, primates
Summary of Study: Preclinical safety evaluation of Intradermal inactivated vaccine (vero cells) administration
References: PMID: 37003910 / doi: 10.1016/j.vaccine.2023.03.033
Contact Info: Qihan Li: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003171?via%3Dihub=