Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Patronus Biotech Co. Ltd., Yantai, China
Keywords: SARS-CoV-2, RBD virus-like particle vaccine, immune response, virus infection, mice, primates
Summary of Study: RBD virus-like particle vaccine induces cross-variant antibody responses
References: PMID: 37120453 / doi: 10.1038/s41392-023-01425-4
Contact Info: Yuanyuan Li: [email protected]
URL: https://www.nature.com/articles/s41392-023-01425-4
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Patronus Biotech Co. Ltd., Yantai, China
Keywords: SARS-CoV-2, RBD virus-like particle vaccine, immune response, virus infection, mice, primates
Summary of Study: RBD virus-like particle vaccine induces cross-variant antibody responses
References: PMID: 37120453 / doi: 10.1038/s41392-023-01425-4
Contact Info: Yuanyuan Li: [email protected]
URL: https://www.nature.com/articles/s41392-023-01425-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Pathology, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liege, Liège, Belgium; others
Keywords: SARS-CoV-2, macrophages, single-cell RNA-seq analysis, immune response, hamsters, primates
Summary of Study: Central role of lung macrophages in SARS-CoV-2 physiopathology: a cross-model single-cell RNA-seq perspective.
References: DOI: 10.3389/fimmu.2023.1197588
Contact Info: Thibaut Olivier: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1197588/full
NHP Species: african green monkeys
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Pathology, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liege, Liège, Belgium; others
Keywords: SARS-CoV-2, macrophages, single-cell RNA-seq analysis, immune response, hamsters, primates
Summary of Study: Central role of lung macrophages in SARS-CoV-2 physiopathology: a cross-model single-cell RNA-seq perspective.
References: DOI: 10.3389/fimmu.2023.1197588
Contact Info: Thibaut Olivier: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1197588/full
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Universitas Airlangga, Surabaya, Indonesia
Keywords: SARS-CoV-2, inactivated vaccine, immune response, primates
Summary of Study: Inactivated SARS-CoV-2 vaccine candidate immunization
References: DOI: 10.1016/j.heliyon.2023.e18039
Contact Info: Fedik Abdul Rantam: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2405844023052477?via%3Dihub
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Universitas Airlangga, Surabaya, Indonesia
Keywords: SARS-CoV-2, inactivated vaccine, immune response, primates
Summary of Study: Inactivated SARS-CoV-2 vaccine candidate immunization
References: DOI: 10.1016/j.heliyon.2023.e18039
Contact Info: Fedik Abdul Rantam: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2405844023052477?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA; University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania, USA; others
Keywords: SARS-CoV-2, tetravalent vaccine, adjuvant, immune response, primates
Summary of Study: Tetravalent SARS-CoV-2 S1 subunit protein vaccination
References: DOI: 10.1128/mbio.02070-23
Contact Info: Andrea Gambotto: [email protected]
URL: https://journals.asm.org/doi/full/10.1128/mbio.02070-23?rfr_dat=cr_pub++0pubmed…
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA; University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania, USA; others
Keywords: SARS-CoV-2, tetravalent vaccine, adjuvant, immune response, primates
Summary of Study: Tetravalent SARS-CoV-2 S1 subunit protein vaccination
References: DOI: 10.1128/mbio.02070-23
Contact Info: Andrea Gambotto: [email protected]
URL: https://journals.asm.org/doi/full/10.1128/mbio.02070-23?rfr_dat=cr_pub++0pubmed…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Research Institute for Biological Safety Problems, The Ministry of Health of the Republic of Kazakhstan
Keywords: SARS-CoV-2, subunit vaccine; antigens; toxicity; safety; immunizing dose; immunogenicity, primates
Summary of Study: Coronavirus protein-based subunit vaccine safety and immunogenicity
References: PMID: 38140175 PMCID: PMC10748237 DOI: 10.3390/vaccines11121771
Contact Info: Ainur Nurpeisova: [email protected]
URL: https://www.mdpi.com/2076-393X/11/12/1771
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Research Institute for Biological Safety Problems, The Ministry of Health of the Republic of Kazakhstan
Keywords: SARS-CoV-2, subunit vaccine; antigens; toxicity; safety; immunizing dose; immunogenicity, primates
Summary of Study: Coronavirus protein-based subunit vaccine safety and immunogenicity
References: PMID: 38140175 PMCID: PMC10748237 DOI: 10.3390/vaccines11121771
Contact Info: Ainur Nurpeisova: [email protected]
URL: https://www.mdpi.com/2076-393X/11/12/1771
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Texas Biomedical Research Institute, Institute of Science and Technology on Biomodels, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
Keywords: SARS-CoV-2, review, coinfections, primate models, housing, screening
Summary of Study: Eliminating Potential Effects of Other Infections During Selection of Nonhuman Primates for COVID-19 Research
References: doi: 10.30802/AALAS-CM-21-000086
Contact Info: Marcia Andrade: [email protected]
URL: https://aalas.kglmeridian.com/view/journals/72010023/73/1/article-p91.xml
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Texas Biomedical Research Institute, Institute of Science and Technology on Biomodels, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
Keywords: SARS-CoV-2, review, coinfections, primate models, housing, screening
Summary of Study: Eliminating Potential Effects of Other Infections During Selection of Nonhuman Primates for COVID-19 Research
References: doi: 10.30802/AALAS-CM-21-000086
Contact Info: Marcia Andrade: [email protected]
URL: https://aalas.kglmeridian.com/view/journals/72010023/73/1/article-p91.xml
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Mymetics SA, Epalinges, Switzerland; Department of Virology, Biomedical Primate Research Centre (BPRC), Rijswijk, The Netherlands; others
Keywords: SARS-CoV-2, influenza virosomes, vaccine, immune response, primates
Summary of Study: Low dose RBD and TLR7/8 agonist displayed on influenza virosome particles is protective
References: doi: 10.1038/s41598-023-31818-y
Contact Info: Sylvain Fleury: [email protected]
URL: https://pubmed.ncbi.nlm.nih.gov/36977691/
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Mymetics SA, Epalinges, Switzerland; Department of Virology, Biomedical Primate Research Centre (BPRC), Rijswijk, The Netherlands; others
Keywords: SARS-CoV-2, influenza virosomes, vaccine, immune response, primates
Summary of Study: Low dose RBD and TLR7/8 agonist displayed on influenza virosome particles is protective
References: doi: 10.1038/s41598-023-31818-y
Contact Info: Sylvain Fleury: [email protected]
URL: https://pubmed.ncbi.nlm.nih.gov/36977691/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Indian Council of Medical Research-National Institute of Virology (ICMR-NIV), Pune, India
Keywords: SARS-CoV-2, immune response, virus variants, vaccine, primates
Summary of Study: Immune response in aged monkeys post vaccine
References: doi: 10.3389/fimmu.2023.1161571
Contact Info: Pragya Yadov: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1161571/full
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Indian Council of Medical Research-National Institute of Virology (ICMR-NIV), Pune, India
Keywords: SARS-CoV-2, immune response, virus variants, vaccine, primates
Summary of Study: Immune response in aged monkeys post vaccine
References: doi: 10.3389/fimmu.2023.1161571
Contact Info: Pragya Yadov: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1161571/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; others
Keywords: SARS-CoV-2, mRNA-lipid nanoparticle vaccine candidate, safety, immune response, mice, primate
Summary of Study: Characterization of stability, safety and immunogenicity of the mRNA lipid nanoparticle vaccine Iribovax® against COVID-19 in nonhuman primates.
References: DOI: 10.1016/j.jconrel.2023.06.025
Contact Info: Sina Mozaffari-Jovin: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S016836592300398X?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; others
Keywords: SARS-CoV-2, mRNA-lipid nanoparticle vaccine candidate, safety, immune response, mice, primate
Summary of Study: Characterization of stability, safety and immunogenicity of the mRNA lipid nanoparticle vaccine Iribovax® against COVID-19 in nonhuman primates.
References: DOI: 10.1016/j.jconrel.2023.06.025
Contact Info: Sina Mozaffari-Jovin: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S016836592300398X?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Bioqual, Rockville, MD; NHLBI, NIAID, others
Keywords: SARS-CoV-2, clonal hematopoiesis, transplantation, immune response, pathology, primates
Summary of Study: Impact of clonal hematopoiesis on severity and pathophysiology
References: DOI: 10.3389/fvets.2023.1182197
Contact Info: Tae-Hoon Shin: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fvets.2023.1182197/full
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Bioqual, Rockville, MD; NHLBI, NIAID, others
Keywords: SARS-CoV-2, clonal hematopoiesis, transplantation, immune response, pathology, primates
Summary of Study: Impact of clonal hematopoiesis on severity and pathophysiology
References: DOI: 10.3389/fvets.2023.1182197
Contact Info: Tae-Hoon Shin: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fvets.2023.1182197/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Institute of Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, USA; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA; others
Keywords: SARS-CoV-2, review, preclinical models, neuropathic physiology, several species, primates
Summary of Study: Preclinical models for studying COVID-19 neurologic diseases
References: DOI: 10.1021/acsptsci.3c00127
Contact Info: Hu Wang: jhmi.edu
URL: https://pubs.acs.org/doi/full/10.1021/acsptsci.3c00127
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Institute of Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, USA; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA; others
Keywords: SARS-CoV-2, review, preclinical models, neuropathic physiology, several species, primates
Summary of Study: Preclinical models for studying COVID-19 neurologic diseases
References: DOI: 10.1021/acsptsci.3c00127
Contact Info: Hu Wang: jhmi.edu
URL: https://pubs.acs.org/doi/full/10.1021/acsptsci.3c00127
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing, China, many others
Keywords: SARS-CoV-2, aerosol immunization, immune response, virus variants, primates
Summary of Study: Inhaled vaccine for single-dose dry powder aerosol immunization
References: PMID: 38093012 DOI: 10.1038/s41586-023-06809-8
Contact Info: Wei Wei: [email protected]
URL: https://www.nature.com/articles/s41586-023-06809-8
NHP Species: cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing, China, many others
Keywords: SARS-CoV-2, aerosol immunization, immune response, virus variants, primates
Summary of Study: Inhaled vaccine for single-dose dry powder aerosol immunization
References: PMID: 38093012 DOI: 10.1038/s41586-023-06809-8
Contact Info: Wei Wei: [email protected]
URL: https://www.nature.com/articles/s41586-023-06809-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Wayne State University, Detroit, Michigan, Center for Comparative Medicine, Massachusetts General Hospital, Boston, Massachusetts, Division of Animal Resources, University of Illinois at Urbana-Champaign, Champaign, Illinois
Keywords: SARS-CoV-2, review, neurological symptoms, humans, mice, hamsters, ferrets, primates
Summary of Study: Animal Models for the Study of Neurologic Manifestations Of COVID-19
References: doi: 10.30802/AALAS-CM-22-000073
Contact Info: Kelsey Carpenter: [email protected]
URL: https://aalas.kglmeridian.com/view/journals/72010023/73/1/article-p91.xml
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Wayne State University, Detroit, Michigan, Center for Comparative Medicine, Massachusetts General Hospital, Boston, Massachusetts, Division of Animal Resources, University of Illinois at Urbana-Champaign, Champaign, Illinois
Keywords: SARS-CoV-2, review, neurological symptoms, humans, mice, hamsters, ferrets, primates
Summary of Study: Animal Models for the Study of Neurologic Manifestations Of COVID-19
References: doi: 10.30802/AALAS-CM-22-000073
Contact Info: Kelsey Carpenter: [email protected]
URL: https://aalas.kglmeridian.com/view/journals/72010023/73/1/article-p91.xml
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Biosystems, Laboratory of Gene Technology, KU Leuven, Leuven Belgium
Keywords: SARS-CoV-2, review, vaccine development, mice, hamsters, primates
Summary of Study: Do we need nasal vaccines against COVID 19
References: doi: 10.1111/1751-7915.14181
Contact Info: Harald Brüssow: [email protected]
URL: https://ami-journals.onlinelibrary.wiley.com/doi/full/10.1111/1751-7915.14181
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Biosystems, Laboratory of Gene Technology, KU Leuven, Leuven Belgium
Keywords: SARS-CoV-2, review, vaccine development, mice, hamsters, primates
Summary of Study: Do we need nasal vaccines against COVID 19
References: doi: 10.1111/1751-7915.14181
Contact Info: Harald Brüssow: [email protected]
URL: https://ami-journals.onlinelibrary.wiley.com/doi/full/10.1111/1751-7915.14181
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2023
Study Type/Review:
NPRC/Institute: Center for Cellular and Molecular Diagnostics, Tulane University School of Medicine, New Orleans, Louisiana; Tulane National Primate Research Center, Covington, Louisiana, others
Keywords: SARS-CoV-2, neuropathology, proteomics, mass-spectrometry, primates
Summary of Study: Cerebrospinal fluid protein markers indicate neuro-damage
References: doi: 10.1016/j.mcpro.2023.100523
Contact Info: Jia Fan: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981268/
NHP Species: rhesus macaques, african green monkeys
Year Published: 2023
Study Type/Review:
NPRC/Institute: Center for Cellular and Molecular Diagnostics, Tulane University School of Medicine, New Orleans, Louisiana; Tulane National Primate Research Center, Covington, Louisiana, others
Keywords: SARS-CoV-2, neuropathology, proteomics, mass-spectrometry, primates
Summary of Study: Cerebrospinal fluid protein markers indicate neuro-damage
References: doi: 10.1016/j.mcpro.2023.100523
Contact Info: Jia Fan: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981268/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: University of Kentucky, Oregon National Primate Research Center, University of California, Irvine
Keywords: SARS-CoV-2, alcohol, lung, scRNA-seq, inflammation, primates
Summary of Study: Alcohol consumption dysregulates immune response in lungs
References: doi: 10.1101/2023.05.02.539139. Preprint
Contact Info: Ilhelm Messaoudi: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187161/
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: University of Kentucky, Oregon National Primate Research Center, University of California, Irvine
Keywords: SARS-CoV-2, alcohol, lung, scRNA-seq, inflammation, primates
Summary of Study: Alcohol consumption dysregulates immune response in lungs
References: doi: 10.1101/2023.05.02.539139. Preprint
Contact Info: Ilhelm Messaoudi: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187161/
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Vaxine Pty Ltd., Warradale, Australia; Flinders University, Bedford Park, Australia; others
Keywords: SARS-CoV-2, spike protein, adjuvanted vaccine, immune response, primates
Summary of Study: Advax-CpG55.2™ adjuvanted recombinant spike protein vaccine protects cynomolgus macaques from a homologous SARS-CoV-2 virus challenge.
References: DOI: 10.1016/j.vaccine.2023.06.063
Contact Info: Nikolai Petrovsky: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X2300748X?via%3Dihub
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Vaxine Pty Ltd., Warradale, Australia; Flinders University, Bedford Park, Australia; others
Keywords: SARS-CoV-2, spike protein, adjuvanted vaccine, immune response, primates
Summary of Study: Advax-CpG55.2™ adjuvanted recombinant spike protein vaccine protects cynomolgus macaques from a homologous SARS-CoV-2 virus challenge.
References: DOI: 10.1016/j.vaccine.2023.06.063
Contact Info: Nikolai Petrovsky: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X2300748X?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: NIAID, Bethesda MD; Weizmann Inst. Of Science, Rehovot, Israel; others
Keywords: SARS-CoV-2, in vitro evolution, ACE2 binding affinity, airways, immune response, primates
Summary of Study: RBD-based high affinity ACE2 antagonist limits SARS-CoV-2 replication in upper and lower airways
References: DOI: 10.1101/2023.06.09.544432
Contact Info: Daniel Douek: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.06.09.544432v1
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: NIAID, Bethesda MD; Weizmann Inst. Of Science, Rehovot, Israel; others
Keywords: SARS-CoV-2, in vitro evolution, ACE2 binding affinity, airways, immune response, primates
Summary of Study: RBD-based high affinity ACE2 antagonist limits SARS-CoV-2 replication in upper and lower airways
References: DOI: 10.1101/2023.06.09.544432
Contact Info: Daniel Douek: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.06.09.544432v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: National Institutes of Health, Islamabad, Pakistan; Department of Pathology and Laboratory Medicine, University of California, Davis, Davis, California, USA; others
Keywords: SARS-CoV-2, mRNA vaccine, immune response, humans, primates
Summary of Study: Immune responses in nonhuman primates and humans immunized with COVID-19 vaccines
References: DOI: 10.1371/journal.pone.0287377
Contact Info: Imran H. Khan: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0287377
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: National Institutes of Health, Islamabad, Pakistan; Department of Pathology and Laboratory Medicine, University of California, Davis, Davis, California, USA; others
Keywords: SARS-CoV-2, mRNA vaccine, immune response, humans, primates
Summary of Study: Immune responses in nonhuman primates and humans immunized with COVID-19 vaccines
References: DOI: 10.1371/journal.pone.0287377
Contact Info: Imran H. Khan: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0287377
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Vaccine Research Center, NIAID, NIH, Bethesda, MD, 20892, USA
Keywords: SARS-CoV-2, mRNA vaccine, immune response, single-cell sequencing, transcriptomics, primates
Summary of Study: Interaction dynamics between innate and adaptive immune cells responding to vaccine
References: PMID: 38042809 PMCID: PMC10693617 DOI: 10.1038/s41467-023-43420-x
Contact Info: Daniel Douek: [email protected]
URL: https://www.nature.com/articles/s41467-023-43420-x
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Vaccine Research Center, NIAID, NIH, Bethesda, MD, 20892, USA
Keywords: SARS-CoV-2, mRNA vaccine, immune response, single-cell sequencing, transcriptomics, primates
Summary of Study: Interaction dynamics between innate and adaptive immune cells responding to vaccine
References: PMID: 38042809 PMCID: PMC10693617 DOI: 10.1038/s41467-023-43420-x
Contact Info: Daniel Douek: [email protected]
URL: https://www.nature.com/articles/s41467-023-43420-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX; Office of Regulated Nonclinical Studies, University of Texas Medical Branch, Galveston, TX; others
Keywords: SARS-CoV-2, Molnupiravir, efficacy, oral administration, primates
Summary of Study: Evaluation of the drug molnupiravir (EIDD-2801) for mild to moderate COVID-19
References: doi: 10.1016/j.antiviral.2022.105492
Contact Info: Jason Comer: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0166354222002613?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX; Office of Regulated Nonclinical Studies, University of Texas Medical Branch, Galveston, TX; others
Keywords: SARS-CoV-2, Molnupiravir, efficacy, oral administration, primates
Summary of Study: Evaluation of the drug molnupiravir (EIDD-2801) for mild to moderate COVID-19
References: doi: 10.1016/j.antiviral.2022.105492
Contact Info: Jason Comer: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0166354222002613?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Social and Administrative Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand; Center of Excellence in Plant-produced Pharmaceuticals, Chulalongkorn University, Bangkok, Thailand; others.
Keywords: SARS-CoV-2, plant-produced subunit vaccine, receptor binding domain, neutralizing antibody, primates
Summary of Study: Preclinical evaluation of immunogenicity, efficacy and safety of a recombinant plant-based vaccine
References: doi: 10.1016/j.vaccine.2023.03.027
Contact Info: Waranyoo Phoolcharoen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003122?via%3Dihub
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Social and Administrative Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand; Center of Excellence in Plant-produced Pharmaceuticals, Chulalongkorn University, Bangkok, Thailand; others.
Keywords: SARS-CoV-2, plant-produced subunit vaccine, receptor binding domain, neutralizing antibody, primates
Summary of Study: Preclinical evaluation of immunogenicity, efficacy and safety of a recombinant plant-based vaccine
References: doi: 10.1016/j.vaccine.2023.03.027
Contact Info: Waranyoo Phoolcharoen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003122?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Stanford University, Scripps Research Institute, others
Keywords: SARS-CoV-2, virus variants, vaccine, immune response, primates
Summary of Study: Extremely potent monoclonal antibodies (mAbs) neutralize multiple sarbecoviruses from macaques vaccinated with AS03-adjuvanted monovalent subunit vaccines.
References: doi: 10.1126/scitranslmed.adg7404
Contact Info: Bali Pulendran: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.adg7404
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Stanford University, Scripps Research Institute, others
Keywords: SARS-CoV-2, virus variants, vaccine, immune response, primates
Summary of Study: Extremely potent monoclonal antibodies (mAbs) neutralize multiple sarbecoviruses from macaques vaccinated with AS03-adjuvanted monovalent subunit vaccines.
References: doi: 10.1126/scitranslmed.adg7404
Contact Info: Bali Pulendran: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.adg7404
Coronavirus Investigated:
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: National Kunming High-level Biosafety Primate Research Center Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College Yunnan China.; State Key Laboratory of Common Mechanism Research for Major Diseases Department of Biochemistry and Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College Beijing China; others
Keywords: SARS-CoV-2, proteomic and phosphoproteomic profiling, liver, virus variants, primates
Summary of Study: Proteomic and phosphoproteomic profiling of SARS?CoV?2?associated liver injury
References: DOI: 10.1002/mco2.358
Contact Info: Juntao Yang: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458660/
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: National Kunming High-level Biosafety Primate Research Center Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College Yunnan China.; State Key Laboratory of Common Mechanism Research for Major Diseases Department of Biochemistry and Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College Beijing China; others
Keywords: SARS-CoV-2, proteomic and phosphoproteomic profiling, liver, virus variants, primates
Summary of Study: Proteomic and phosphoproteomic profiling of SARS?CoV?2?associated liver injury
References: DOI: 10.1002/mco2.358
Contact Info: Juntao Yang: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458660/
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: University of Maryland School of Medicine, Baltimore, MD; others
Keywords: SARS-CoV-2, prefusion-stabilized spike protein, vaccine, immune response, virus variants, primates
Summary of Study: Immunogenicity and protection of a variant nanoparticle vaccine
References: DOI: 10.1038/s41467-022-35606-6
Contact Info: Matthew B. Frieman: [email protected]
URL: https://www.nature.com/articles/s41467-022-35606-6
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: University of Maryland School of Medicine, Baltimore, MD; others
Keywords: SARS-CoV-2, prefusion-stabilized spike protein, vaccine, immune response, virus variants, primates
Summary of Study: Immunogenicity and protection of a variant nanoparticle vaccine
References: DOI: 10.1038/s41467-022-35606-6
Contact Info: Matthew B. Frieman: [email protected]
URL: https://www.nature.com/articles/s41467-022-35606-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Tonix Pharmaceuticals; others
Keywords: SARS-CoV-2, vaccine, horsepox virus, spike protein, antibody titer, immunogenicity, primates
Summary of Study: TNX-1800, a live virus recombinant poxvirus vaccine candidate
References: PMID: 38006014 PMCID: PMC10674175 DOI: 10.3390/vaccines11111682
Contact Info: Seth Lederman: seth.lederman@tonix
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674175/pdf/vaccines-11-01682.pdf
NHP Species: african green monkeys, cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Tonix Pharmaceuticals; others
Keywords: SARS-CoV-2, vaccine, horsepox virus, spike protein, antibody titer, immunogenicity, primates
Summary of Study: TNX-1800, a live virus recombinant poxvirus vaccine candidate
References: PMID: 38006014 PMCID: PMC10674175 DOI: 10.3390/vaccines11111682
Contact Info: Seth Lederman: seth.lederman@tonix
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674175/pdf/vaccines-11-01682.pdf
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review: pathogenesis, review
NPRC/Institute: Primate Resources Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup-si, Jeonbuk, Korea; Korea National University of Science and Technology (UST), Daejeon, Korea.
Keywords: SARS-CoV-2, animal models, species sensitivity, other viruses, primates
Summary of Study: NHPs to combat COVID-19 and viral infectious disease outbreaks
References: PMID: 38084001 DOI: 10.1111/jmp.12689
Contact Info: Taeho Kwan: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1111/jmp.12689
NHP Species: multiple species
Year Published: 2023
Study Type/Review: pathogenesis, review
NPRC/Institute: Primate Resources Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup-si, Jeonbuk, Korea; Korea National University of Science and Technology (UST), Daejeon, Korea.
Keywords: SARS-CoV-2, animal models, species sensitivity, other viruses, primates
Summary of Study: NHPs to combat COVID-19 and viral infectious disease outbreaks
References: PMID: 38084001 DOI: 10.1111/jmp.12689
Contact Info: Taeho Kwan: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1111/jmp.12689
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland; Adimab LLC, Lebanon, New Hampshire; Invivyd, Inc., Waltham, Massachusetts; others
Keywords: SARS-CoV-2, Adintrevimab, prophylactics, viral load, pathology, hamsters, primates
Summary of Study: Monoclonal Antibody Adintrevimab Protects against COVID-19
References: doi: 10.1128/aac.01353-22
Contact Info: Kristin Narayan: [email protected]
URL: https://journals.asm.org/doi/10.1128/aac.01353-22
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland; Adimab LLC, Lebanon, New Hampshire; Invivyd, Inc., Waltham, Massachusetts; others
Keywords: SARS-CoV-2, Adintrevimab, prophylactics, viral load, pathology, hamsters, primates
Summary of Study: Monoclonal Antibody Adintrevimab Protects against COVID-19
References: doi: 10.1128/aac.01353-22
Contact Info: Kristin Narayan: [email protected]
URL: https://journals.asm.org/doi/10.1128/aac.01353-22
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: University of Oklahoma Health Sciences Center, Oklahoma City, OK USA and others.
Keywords: SARS-CoV-2, air–liquid interface, airway epithelium, immune response, innate immunity, inflammation, primates
Summary of Study: Isolation and in vitro differentiation of primary fetal baboon tracheal epithelial cells for studying host-virus Interactions
References: PMID: 37112842 / doi: 10.3390/v15040862
Contact Info: Matthew Walters: [email protected]
URL: https://www.mdpi.com/1999-4915/15/4/862
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: University of Oklahoma Health Sciences Center, Oklahoma City, OK USA and others.
Keywords: SARS-CoV-2, air–liquid interface, airway epithelium, immune response, innate immunity, inflammation, primates
Summary of Study: Isolation and in vitro differentiation of primary fetal baboon tracheal epithelial cells for studying host-virus Interactions
References: PMID: 37112842 / doi: 10.3390/v15040862
Contact Info: Matthew Walters: [email protected]
URL: https://www.mdpi.com/1999-4915/15/4/862
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Emory National Primate Research Center, Emory School of Medicine, others
Keywords: SARS-CoV-2, vaccine comparison, immune response, nasopharynx, primates
Summary of Study: Efficacy of mRNA-1273 and Novavax ancestral or BA.1 spike booster vaccines
References: doi: 10.1126/sciimmunol.adg7015
Contact Info: Rama Rao Amara: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.adg7015
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Emory National Primate Research Center, Emory School of Medicine, others
Keywords: SARS-CoV-2, vaccine comparison, immune response, nasopharynx, primates
Summary of Study: Efficacy of mRNA-1273 and Novavax ancestral or BA.1 spike booster vaccines
References: doi: 10.1126/sciimmunol.adg7015
Contact Info: Rama Rao Amara: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.adg7015
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Janssen Research and Development, Beerse, Belgium and Janssen Vaccines and Prevention B.V., Leiden, The Netherlands
Keywords: SARS-CoV-2, mechanistic modeling, vaccination, immune response, primates
Summary of Study: Humoral Immunity Following Ad26.COV2.S Vaccination
References: DOI: 10.1124/jpet.123.001591
Contact Info: Anna Dari: [email protected]
URL: https://jpet.aspetjournals.org/content/387/1/121.long
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Janssen Research and Development, Beerse, Belgium and Janssen Vaccines and Prevention B.V., Leiden, The Netherlands
Keywords: SARS-CoV-2, mechanistic modeling, vaccination, immune response, primates
Summary of Study: Humoral Immunity Following Ad26.COV2.S Vaccination
References: DOI: 10.1124/jpet.123.001591
Contact Info: Anna Dari: [email protected]
URL: https://jpet.aspetjournals.org/content/387/1/121.long
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Federal Medical-Biological Agency of Russia, Moscow, Russia; Saint Petersburg Scientific Research Institute of Vaccines and Serums of the Federal Medical-Biological Agency of Russia; others
Keywords: SARS-CoV-2, nucleocapsid, vaccine, immune response, primates
Summary of Study: Recombinant Nucleocapsid-Based Vaccine Convacell®
References: DOI: 10.3390/vaccines11040874
Contact Info: Sevastyan Rabdano: [email protected]
URL: https://www.mdpi.com/2076-393X/11/4/874
NHP Species: multiple species
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Federal Medical-Biological Agency of Russia, Moscow, Russia; Saint Petersburg Scientific Research Institute of Vaccines and Serums of the Federal Medical-Biological Agency of Russia; others
Keywords: SARS-CoV-2, nucleocapsid, vaccine, immune response, primates
Summary of Study: Recombinant Nucleocapsid-Based Vaccine Convacell®
References: DOI: 10.3390/vaccines11040874
Contact Info: Sevastyan Rabdano: [email protected]
URL: https://www.mdpi.com/2076-393X/11/4/874
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: therapeutics
NPRC/Institute: Oregon National Primate Research Center and numerous collaborators
Keywords: SARS-CoV-2, aerosol mAb, immune response, protection, primates
Summary of Study: Aerosol delivery of monoclonal antibodies limits viral replication and lung pathology
References: PMID: 37923717 PMCID: PMC10624670 DOI: 10.1038/s41467-023-42440-x
Contact Info: Nancy Haigwood: [email protected]
URL: https://www.nature.com/articles/s41467-023-42440-x
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: therapeutics
NPRC/Institute: Oregon National Primate Research Center and numerous collaborators
Keywords: SARS-CoV-2, aerosol mAb, immune response, protection, primates
Summary of Study: Aerosol delivery of monoclonal antibodies limits viral replication and lung pathology
References: PMID: 37923717 PMCID: PMC10624670 DOI: 10.1038/s41467-023-42440-x
Contact Info: Nancy Haigwood: [email protected]
URL: https://www.nature.com/articles/s41467-023-42440-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA, others
Keywords: SARS-CoV-2, intratracheal boosting, bivalent Ad26-based vaccine, immune response, primates
Summary of Study: Mucosal boosting enhances vaccine protection
References: PMID: 38096903 DOI: 10.1038/s41586-023-06951-3
Contact Info: Dan Barouch: [email protected]
URL: https://www.nature.com/articles/s41586-023-06951-3
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA, others
Keywords: SARS-CoV-2, intratracheal boosting, bivalent Ad26-based vaccine, immune response, primates
Summary of Study: Mucosal boosting enhances vaccine protection
References: PMID: 38096903 DOI: 10.1038/s41586-023-06951-3
Contact Info: Dan Barouch: [email protected]
URL: https://www.nature.com/articles/s41586-023-06951-3
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Fudan University; The University of Hong Kong; Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park; Graduate School of Peking Union Medical College; National Institute for Food and Drug Control, Beijing, China; Fulgent Pharma LLC
Keywords: SARS-CoV-2, pan-sarbecovirus vaccine, immune response, virus variants, primates
Summary of Study: A pan-sarbecovirus vaccine consisting of human IgG Fc fragment-conjugated RBC of the original SARS-CoV-2 WA1 strain as the immunogen and a novel small-molecule non-nucleotide STING agonist as the adjuvant could be used to prevent infection by the current SARS-CoV-2 variants, including Omicron, and future emerging sarbecoviruses.
References: PMID: 35210607 / doi: 10. 1038/s41422-022-00631-z
Contact Info: Youchun Wang: [email protected]
URL: https://www.nature.com/articles/s41422-022-00631-z
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Fudan University; The University of Hong Kong; Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park; Graduate School of Peking Union Medical College; National Institute for Food and Drug Control, Beijing, China; Fulgent Pharma LLC
Keywords: SARS-CoV-2, pan-sarbecovirus vaccine, immune response, virus variants, primates
Summary of Study: A pan-sarbecovirus vaccine consisting of human IgG Fc fragment-conjugated RBC of the original SARS-CoV-2 WA1 strain as the immunogen and a novel small-molecule non-nucleotide STING agonist as the adjuvant could be used to prevent infection by the current SARS-CoV-2 variants, including Omicron, and future emerging sarbecoviruses.
References: PMID: 35210607 / doi: 10. 1038/s41422-022-00631-z
Contact Info: Youchun Wang: [email protected]
URL: https://www.nature.com/articles/s41422-022-00631-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tsinghua University; Chongqing Medical University; Boston University School of Medicine; Chinese Academy of Sciences; Shenzhen Bay Laboratory; Peking University Shenshen Graduate School; Fudan University
Keywords: SARS-CoV-2, pathogenesis, neutralization antibodies, primates
Summary of Study: Kappa, Delta, or B.1.618 spike uses human angiotensin-converting enzyme 2 (ACE2) with no or slightly increased efficiency, while it gains a significantly increased binding affinity with mouse, marmoset, and koala ACE2 orthologs, which exhibit limited binding with wild-type (WT) spike. Collectively, this study revealed that enhanced human and mouse ASE receptor engagement, increased spike cleavage, and reduced sensitivity to neutralization antibodies of Kapa, Delta and B.1.618 may contribute to the rapid spread of these variants.
References: PMID: 35266815 / doi: 10.1128/mbio.00099-22
Contact Info: Qiang Ding: [email protected]
URL: https://journals.asm.org/doi/full/10.1128/mbio.00099-22?rfr_dat=cr_pub++0pubmed…
NHP Species: marmosets
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tsinghua University; Chongqing Medical University; Boston University School of Medicine; Chinese Academy of Sciences; Shenzhen Bay Laboratory; Peking University Shenshen Graduate School; Fudan University
Keywords: SARS-CoV-2, pathogenesis, neutralization antibodies, primates
Summary of Study: Kappa, Delta, or B.1.618 spike uses human angiotensin-converting enzyme 2 (ACE2) with no or slightly increased efficiency, while it gains a significantly increased binding affinity with mouse, marmoset, and koala ACE2 orthologs, which exhibit limited binding with wild-type (WT) spike. Collectively, this study revealed that enhanced human and mouse ASE receptor engagement, increased spike cleavage, and reduced sensitivity to neutralization antibodies of Kapa, Delta and B.1.618 may contribute to the rapid spread of these variants.
References: PMID: 35266815 / doi: 10.1128/mbio.00099-22
Contact Info: Qiang Ding: [email protected]
URL: https://journals.asm.org/doi/full/10.1128/mbio.00099-22?rfr_dat=cr_pub++0pubmed…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane School of Medicine
Keywords: SARS-CoV-2, monoclonal antibody prophylaxis, virus reproduction, primates
Summary of Study: High viral loads were observed in the intestinal mucosa of a rhesus macaque post challenge with SARS-CoV-2 after prophylactic administration of combination anti-spike antibody therapy. Intrahost evolution of virus was seen, with sequences changing in accordance with enhanced replication capacity, as well as site-specific differences potentially indicating preferential replication.
References: PMID: 35429402 / doi: 10.1093/infdis/jiac134
Contact Info: Chad Roy: [email protected]
URL: https://academic.oup.com/jid/article/226/9/1588/6569365?login=false
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane School of Medicine
Keywords: SARS-CoV-2, monoclonal antibody prophylaxis, virus reproduction, primates
Summary of Study: High viral loads were observed in the intestinal mucosa of a rhesus macaque post challenge with SARS-CoV-2 after prophylactic administration of combination anti-spike antibody therapy. Intrahost evolution of virus was seen, with sequences changing in accordance with enhanced replication capacity, as well as site-specific differences potentially indicating preferential replication.
References: PMID: 35429402 / doi: 10.1093/infdis/jiac134
Contact Info: Chad Roy: [email protected]
URL: https://academic.oup.com/jid/article/226/9/1588/6569365?login=false
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Universite Paris-Saclay, INSERM, CEA; Life and Soft; IRCCS Ospedale San Raffaele; Institut Pasteur
Keywords: SARS-CoV-2, neonate animals, immune response, pathology, primates
Summary of Study: This pilot study demonstrates that neonatal NHPs are a relevant model for pediatric SARS-CoV-2 infection.
References: PMID: 35603150 / doi: 10.3389/fimmu.2022.855230
Contact Info: Nabila Seddiki: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.855230/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Universite Paris-Saclay, INSERM, CEA; Life and Soft; IRCCS Ospedale San Raffaele; Institut Pasteur
Keywords: SARS-CoV-2, neonate animals, immune response, pathology, primates
Summary of Study: This pilot study demonstrates that neonatal NHPs are a relevant model for pediatric SARS-CoV-2 infection.
References: PMID: 35603150 / doi: 10.3389/fimmu.2022.855230
Contact Info: Nabila Seddiki: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.855230/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Tulane University School of Medicine; Beijing Forestry University; Beijing Institute of Lifeomics; Ochsner Clinic Foundation; University of Texas Southwestern Medical Center; Tulane National Primate Research Center
Keywords: SARS-CoV-2, peptide microarrays, neutralizing antibodies, vaccine, primates
Summary of Study: Linear peptide epitopes detected by immunoglobulins after infection have been localized to functionally important virus regions, which can be used to inform vaccine evaluation and targets for site-specific therapy.
References: PMID: 35928300 / doi: 10.34133/2022/9769803
Contact Info: Xiaobo Yu: [email protected]; Tony Hu: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297724/
NHP Species: african green monkeys, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Tulane University School of Medicine; Beijing Forestry University; Beijing Institute of Lifeomics; Ochsner Clinic Foundation; University of Texas Southwestern Medical Center; Tulane National Primate Research Center
Keywords: SARS-CoV-2, peptide microarrays, neutralizing antibodies, vaccine, primates
Summary of Study: Linear peptide epitopes detected by immunoglobulins after infection have been localized to functionally important virus regions, which can be used to inform vaccine evaluation and targets for site-specific therapy.
References: PMID: 35928300 / doi: 10.34133/2022/9769803
Contact Info: Xiaobo Yu: [email protected]; Tony Hu: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297724/
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Université Paris-Saclay; Université de Paris; Laboratoire de Pharmacocinétique et Toxicologie; Institut Pasteur; Centre International de Recherche en Infectiologie; Unité des Virus Emergents, Aix Marseille Univ; VirNext, Université Claude Bernard Lyon 1; University Hospital, Bordeaux & Inserm
Keywords: SARS-CoV-2, Zika, favipiravir, antiviral activity, primates
Summary of Study: A nucleoside analogue with activity against RNA viruses shows antiviral activity that reduces viral load and kinetics in Zika, but not COVID-19.
References: PMID: 36042198 / doi: 10.1038/s41467-022-32565-w
Contact Info: Roger Le Grand: [email protected]; Jeremie Guedj: [email protected]
URL: https://www.nature.com/articles/s41467-022-32565-w
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Université Paris-Saclay; Université de Paris; Laboratoire de Pharmacocinétique et Toxicologie; Institut Pasteur; Centre International de Recherche en Infectiologie; Unité des Virus Emergents, Aix Marseille Univ; VirNext, Université Claude Bernard Lyon 1; University Hospital, Bordeaux & Inserm
Keywords: SARS-CoV-2, Zika, favipiravir, antiviral activity, primates
Summary of Study: A nucleoside analogue with activity against RNA viruses shows antiviral activity that reduces viral load and kinetics in Zika, but not COVID-19.
References: PMID: 36042198 / doi: 10.1038/s41467-022-32565-w
Contact Info: Roger Le Grand: [email protected]; Jeremie Guedj: [email protected]
URL: https://www.nature.com/articles/s41467-022-32565-w
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shionogi & Co., Ltd., Biopharmaceutical Research Division, Osaka, Japan
Keywords: SARS-CoV-2, recombinant spike protein vaccine, virus variants, immune response
Summary of Study: Homologous and heterologous booster vaccinations of S-268019-b, a recombinant S protein-based vaccine
References: doi: 10.1016/j.vaccine.2022.10.092
Contact Info: Shinya Omoto: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22013792?via%3Dihub
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shionogi & Co., Ltd., Biopharmaceutical Research Division, Osaka, Japan
Keywords: SARS-CoV-2, recombinant spike protein vaccine, virus variants, immune response
Summary of Study: Homologous and heterologous booster vaccinations of S-268019-b, a recombinant S protein-based vaccine
References: doi: 10.1016/j.vaccine.2022.10.092
Contact Info: Shinya Omoto: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22013792?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Washington University; National Cancer Institute/NIH; Bioqual; Oak Ridge Institute of Science & Education; Columbia University Vagelos College of Physicians and Surgeons; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, spike protein ferritin nanoparticle (SpFN) vaccine, immune response, primates
Summary of Study: NHPs vaccinated with two doses of SpFN plus adjuvant separated by 28 days developed potent SARS-CoV-2-specific B and T cell responses, which conferred protection against SARS-CoV-2 challenge.
References: PMID: 34914540 / doi: 10.1126/scitranslmed.abi5735
Contact Info: Kayvon Modjarrad: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abi5735?url_ver=Z39.88-2003&rf…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Washington University; National Cancer Institute/NIH; Bioqual; Oak Ridge Institute of Science & Education; Columbia University Vagelos College of Physicians and Surgeons; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, spike protein ferritin nanoparticle (SpFN) vaccine, immune response, primates
Summary of Study: NHPs vaccinated with two doses of SpFN plus adjuvant separated by 28 days developed potent SARS-CoV-2-specific B and T cell responses, which conferred protection against SARS-CoV-2 challenge.
References: PMID: 34914540 / doi: 10.1126/scitranslmed.abi5735
Contact Info: Kayvon Modjarrad: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abi5735?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: prevention
NPRC/Institute: University of Washington; Washington National Primate Research Center; Institute of Biomedical Sciences, Taipei; Fred Hutchinson Cancer Research Center
Keywords: SARS-CoV-2, helper-dependent adenovirus (HDAd5/35++), HSC gene therapy, safety, virus protection, mice, primates
Summary of Study: Pilot studies of a simple and portable in vivo hematopoietic HSC transduction approach that involves HSC mobilization from the bone marrow into the peripheral blood stream and the intravenous injection of an integrating, helper-dependent adenovirus vector system demonstrated safety and efficacy in mice and a rhesus macaque.
References: PMID: 35057635 / doi: 10.1089/hum.2021.295
Contact Info: Andre Lieber: [email protected]; Steve Roffler: [email protected]; Hans-Peter Kiem: [email protected]; Deborah Fuller: [email protected]
URL: https://www.liebertpub.com/doi/10.1089/hum.2021.295?url_ver=Z39.88-2003&rfr_id=…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: prevention
NPRC/Institute: University of Washington; Washington National Primate Research Center; Institute of Biomedical Sciences, Taipei; Fred Hutchinson Cancer Research Center
Keywords: SARS-CoV-2, helper-dependent adenovirus (HDAd5/35++), HSC gene therapy, safety, virus protection, mice, primates
Summary of Study: Pilot studies of a simple and portable in vivo hematopoietic HSC transduction approach that involves HSC mobilization from the bone marrow into the peripheral blood stream and the intravenous injection of an integrating, helper-dependent adenovirus vector system demonstrated safety and efficacy in mice and a rhesus macaque.
References: PMID: 35057635 / doi: 10.1089/hum.2021.295
Contact Info: Andre Lieber: [email protected]; Steve Roffler: [email protected]; Hans-Peter Kiem: [email protected]; Deborah Fuller: [email protected]
URL: https://www.liebertpub.com/doi/10.1089/hum.2021.295?url_ver=Z39.88-2003&rfr_id=…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Henry M. Jackson Foundation for the Advancement of Military Medicine; Washington University; NCI/NIH; Bioqual; Oak Ridge Institute of Science and Education; Columbia University Vagelos College of Physicians and Surgeons; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, nanoparticle vaccine, cellular and humoral immune responses, primates
Summary of Study: Nonhuman primates vaccinated with two doses of SpFN (a SARS-CoV-2 spike protein ferritin nanoparticle vaccine) were protected against SARS-CoV-2 challenge. SErum isolated from vaccinated animals neutralized several variants of concern, including the delta variant.
References: PMID: 39414540 / doi: 10.1126/scitranslmed.abi5735
Contact Info: M. Gordon Joyce: [email protected]; Kayvon Modjarrad: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abi5735
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Henry M. Jackson Foundation for the Advancement of Military Medicine; Washington University; NCI/NIH; Bioqual; Oak Ridge Institute of Science and Education; Columbia University Vagelos College of Physicians and Surgeons; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, nanoparticle vaccine, cellular and humoral immune responses, primates
Summary of Study: Nonhuman primates vaccinated with two doses of SpFN (a SARS-CoV-2 spike protein ferritin nanoparticle vaccine) were protected against SARS-CoV-2 challenge. SErum isolated from vaccinated animals neutralized several variants of concern, including the delta variant.
References: PMID: 39414540 / doi: 10.1126/scitranslmed.abi5735
Contact Info: M. Gordon Joyce: [email protected]; Kayvon Modjarrad: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abi5735
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: MIT; Scripps Research Institute; La Jolla Institute for Immunology; Ragon Institute of Massachusetts General Hospital, MIT, and Harvard University; University of California, San Diego; Yerkes National Primate Research Center; Emory University School of Medicine; MIT
Keywords: SARS-CoV-2, saponin/TLR agonist, vaccine adjuvant, immune response, primates
Summary of Study: Compared with a panel of tested adjuvants including other saponin-based formulations, saponin/MPLA nanoparticles (SMNP) induced superior antibody and germinal center responses after immunization with a poorly immunogenic HIV antigen in both mice and rhesus macaques, suggesting that SMNP may be a promising adjuvant in the setting of HIV, SARS-CoV-2, and other pathogens.
References: PMID: 34860581 / doi: 10.1126/sciimmunol.abf1152
Contact Info: Darrell J. Irvine: [email protected]; Shane Crotty: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.abf1152?url_ver=Z39.88-2003&rfr_…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: MIT; Scripps Research Institute; La Jolla Institute for Immunology; Ragon Institute of Massachusetts General Hospital, MIT, and Harvard University; University of California, San Diego; Yerkes National Primate Research Center; Emory University School of Medicine; MIT
Keywords: SARS-CoV-2, saponin/TLR agonist, vaccine adjuvant, immune response, primates
Summary of Study: Compared with a panel of tested adjuvants including other saponin-based formulations, saponin/MPLA nanoparticles (SMNP) induced superior antibody and germinal center responses after immunization with a poorly immunogenic HIV antigen in both mice and rhesus macaques, suggesting that SMNP may be a promising adjuvant in the setting of HIV, SARS-CoV-2, and other pathogens.
References: PMID: 34860581 / doi: 10.1126/sciimmunol.abf1152
Contact Info: Darrell J. Irvine: [email protected]; Shane Crotty: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.abf1152?url_ver=Z39.88-2003&rfr_…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Biomedical Primate Research Centre; Consejo Superior de Investigaciones Cientificas (CSIC); Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas (CIBERINFEC); Erasmus Medical Center; Instituto de Investigacion Hospital Universitario 12 de Octubre (imas12); Universidad Complutense School of Medicine, Biofabri
Keywords: SARS-CoV-2, vaccine, modified vaccinia virus Ankara vector, immune response, primates
Summary of Study: The MVA-S vaccine is safe and well tolerated in rhesus macaques, being highly immunogenic with the induction of potent levels of binding and neutralizing antibodies against several SARS-CoV-2 VOC, as well as Th1-skewed cell responses.
References: PMID: 35371043 / doi: 10.3389/fimmu.2022.845887
Contact Info: Petra Mooij: [email protected]; Juan Garcia-Arriaza: [email protected]; Gerrit Koopman: [email protected]; Mariano Esteban: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.845887/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Biomedical Primate Research Centre; Consejo Superior de Investigaciones Cientificas (CSIC); Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas (CIBERINFEC); Erasmus Medical Center; Instituto de Investigacion Hospital Universitario 12 de Octubre (imas12); Universidad Complutense School of Medicine, Biofabri
Keywords: SARS-CoV-2, vaccine, modified vaccinia virus Ankara vector, immune response, primates
Summary of Study: The MVA-S vaccine is safe and well tolerated in rhesus macaques, being highly immunogenic with the induction of potent levels of binding and neutralizing antibodies against several SARS-CoV-2 VOC, as well as Th1-skewed cell responses.
References: PMID: 35371043 / doi: 10.3389/fimmu.2022.845887
Contact Info: Petra Mooij: [email protected]; Juan Garcia-Arriaza: [email protected]; Gerrit Koopman: [email protected]; Mariano Esteban: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.845887/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre (BPRC), Rijswijk, Netherlands; Department of Radiology and Nuclear Medicine, Tracer Center Amsterdam (TCA), Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands
Keywords: SARS-CoV-2, PET-CT imaging, lungs, inflammation, primates
Summary of Study: Vaccine candidate involving a valuable radiotracer to visualize SARS-CoV-2-associated pulmonary inflammation
References: PMID: 35660200 PMCID: PMC9148436 DOI: 10.1016/j.nucmedbio.2022.05.002
Contact Info: Marieke A Stammes: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0969805122020509?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre (BPRC), Rijswijk, Netherlands; Department of Radiology and Nuclear Medicine, Tracer Center Amsterdam (TCA), Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands
Keywords: SARS-CoV-2, PET-CT imaging, lungs, inflammation, primates
Summary of Study: Vaccine candidate involving a valuable radiotracer to visualize SARS-CoV-2-associated pulmonary inflammation
References: PMID: 35660200 PMCID: PMC9148436 DOI: 10.1016/j.nucmedbio.2022.05.002
Contact Info: Marieke A Stammes: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0969805122020509?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2022
Study Type/Review:
NPRC/Institute: Defence Science and Technology Laboratory; United Kingdom Health and Security Agency
Keywords: SARS-CoV-2, aerosolized virus, pathology, immune response, primates
Summary of Study: Following COVID-19 exposure, marmosets did not develop clinical signs other than a disruption to the diurnal temperature rhythm. This may be due to an innate immunological response, which included an increase in neutrophils and monocytes and a reduction in T-cells.
References: PMID: 35891560 / doi: 10.3390/v14071580
Contact Info: Rachel Ireland: [email protected]
URL: https://www.mdpi.com/1999-4915/14/7/1580
NHP Species: marmosets
Year Published: 2022
Study Type/Review:
NPRC/Institute: Defence Science and Technology Laboratory; United Kingdom Health and Security Agency
Keywords: SARS-CoV-2, aerosolized virus, pathology, immune response, primates
Summary of Study: Following COVID-19 exposure, marmosets did not develop clinical signs other than a disruption to the diurnal temperature rhythm. This may be due to an innate immunological response, which included an increase in neutrophils and monocytes and a reduction in T-cells.
References: PMID: 35891560 / doi: 10.3390/v14071580
Contact Info: Rachel Ireland: [email protected]
URL: https://www.mdpi.com/1999-4915/14/7/1580
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: China Biotechnology Co.LTD; Beijing Chaoyang Hospital, Capital Medical University; Laboratory Animal Center, Academy of Military Medical Sciences
Keywords: SARS-CoV-2, angiotensin-converting enzyme 2, gene sequences, primates
Summary of Study: Angiotensin-converting enzyme (ACE2) binds to the SARS-CoV2 virus as a receptor, and variation of the ACE2 sequence and binding affinity may account for differences in susceptibility and responses to infection
References: PMID: 36105891 / doi: 10.1016/j.bsheal.2022.09.001
Contact Info: Xiaojun Zhou, Jingjing Zhao, Yefeng Qiu, Rui Jia
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461283/
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: China Biotechnology Co.LTD; Beijing Chaoyang Hospital, Capital Medical University; Laboratory Animal Center, Academy of Military Medical Sciences
Keywords: SARS-CoV-2, angiotensin-converting enzyme 2, gene sequences, primates
Summary of Study: Angiotensin-converting enzyme (ACE2) binds to the SARS-CoV2 virus as a receptor, and variation of the ACE2 sequence and binding affinity may account for differences in susceptibility and responses to infection
References: PMID: 36105891 / doi: 10.1016/j.bsheal.2022.09.001
Contact Info: Xiaojun Zhou, Jingjing Zhao, Yefeng Qiu, Rui Jia
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9461283/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Respiratory Disease, China; Guanzhou Laboratory, China; University of Science and Technology Hong Kong, numerous others
Keywords: SARS-CoV-2, spike protein vaccine, immune response, virus variants, mice, primates
Summary of Study: RBMRNA-176 is a vaccine candidate for prevention of COVID-19
References: doi: 10.3390/vaccines10101698
Contact Info: Wei Yang: [email protected]
URL: https://www.mdpi.com/2076-393X/10/10/1698
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Respiratory Disease, China; Guanzhou Laboratory, China; University of Science and Technology Hong Kong, numerous others
Keywords: SARS-CoV-2, spike protein vaccine, immune response, virus variants, mice, primates
Summary of Study: RBMRNA-176 is a vaccine candidate for prevention of COVID-19
References: doi: 10.3390/vaccines10101698
Contact Info: Wei Yang: [email protected]
URL: https://www.mdpi.com/2076-393X/10/10/1698