Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Social and Administrative Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand; Center of Excellence in Plant-produced Pharmaceuticals, Chulalongkorn University, Bangkok, Thailand; others.
Keywords: SARS-CoV-2, plant-produced subunit vaccine, receptor binding domain, neutralizing antibody, primates
Summary of Study: Preclinical evaluation of immunogenicity, efficacy and safety of a recombinant plant-based vaccine
References: doi: 10.1016/j.vaccine.2023.03.027
Contact Info: Waranyoo Phoolcharoen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003122?via%3Dihub=
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Social and Administrative Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand; Center of Excellence in Plant-produced Pharmaceuticals, Chulalongkorn University, Bangkok, Thailand; others.
Keywords: SARS-CoV-2, plant-produced subunit vaccine, receptor binding domain, neutralizing antibody, primates
Summary of Study: Preclinical evaluation of immunogenicity, efficacy and safety of a recombinant plant-based vaccine
References: doi: 10.1016/j.vaccine.2023.03.027
Contact Info: Waranyoo Phoolcharoen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003122?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Stanford University, Scripps Research Institute, others
Keywords: SARS-CoV-2, virus variants, vaccine, immune response, primates
Summary of Study: Extremely potent monoclonal antibodies (mAbs) neutralize multiple sarbecoviruses from macaques vaccinated with AS03-adjuvanted monovalent subunit vaccines.
References: doi: 10.1126/scitranslmed.adg7404
Contact Info: Bali Pulendran: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.adg7404
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Stanford University, Scripps Research Institute, others
Keywords: SARS-CoV-2, virus variants, vaccine, immune response, primates
Summary of Study: Extremely potent monoclonal antibodies (mAbs) neutralize multiple sarbecoviruses from macaques vaccinated with AS03-adjuvanted monovalent subunit vaccines.
References: doi: 10.1126/scitranslmed.adg7404
Contact Info: Bali Pulendran: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.adg7404
Coronavirus Investigated:
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: National Kunming High-level Biosafety Primate Research Center Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College Yunnan China.; State Key Laboratory of Common Mechanism Research for Major Diseases Department of Biochemistry and Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College Beijing China; others
Keywords: SARS-CoV-2, proteomic and phosphoproteomic profiling, liver, virus variants, primates
Summary of Study: Proteomic and phosphoproteomic profiling of SARS?CoV?2?associated liver injury
References: DOI: 10.1002/mco2.358
Contact Info: Juntao Yang: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458660/
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: National Kunming High-level Biosafety Primate Research Center Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College Yunnan China.; State Key Laboratory of Common Mechanism Research for Major Diseases Department of Biochemistry and Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College Beijing China; others
Keywords: SARS-CoV-2, proteomic and phosphoproteomic profiling, liver, virus variants, primates
Summary of Study: Proteomic and phosphoproteomic profiling of SARS?CoV?2?associated liver injury
References: DOI: 10.1002/mco2.358
Contact Info: Juntao Yang: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458660/
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: University of Maryland School of Medicine, Baltimore, MD; others
Keywords: SARS-CoV-2, prefusion-stabilized spike protein, vaccine, immune response, virus variants, primates
Summary of Study: Immunogenicity and protection of a variant nanoparticle vaccine
References: DOI: 10.1038/s41467-022-35606-6
Contact Info: Matthew B. Frieman: [email protected]
URL: https://www.nature.com/articles/s41467-022-35606-6
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: University of Maryland School of Medicine, Baltimore, MD; others
Keywords: SARS-CoV-2, prefusion-stabilized spike protein, vaccine, immune response, virus variants, primates
Summary of Study: Immunogenicity and protection of a variant nanoparticle vaccine
References: DOI: 10.1038/s41467-022-35606-6
Contact Info: Matthew B. Frieman: [email protected]
URL: https://www.nature.com/articles/s41467-022-35606-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Tonix Pharmaceuticals; others
Keywords: SARS-CoV-2, vaccine, horsepox virus, spike protein, antibody titer, immunogenicity, primates
Summary of Study: TNX-1800, a live virus recombinant poxvirus vaccine candidate
References: PMID: 38006014 PMCID: PMC10674175 DOI: 10.3390/vaccines11111682
Contact Info: Seth Lederman: seth.lederman@tonix
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674175/pdf/vaccines-11-01682.pdf
NHP Species: african green monkeys, cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Tonix Pharmaceuticals; others
Keywords: SARS-CoV-2, vaccine, horsepox virus, spike protein, antibody titer, immunogenicity, primates
Summary of Study: TNX-1800, a live virus recombinant poxvirus vaccine candidate
References: PMID: 38006014 PMCID: PMC10674175 DOI: 10.3390/vaccines11111682
Contact Info: Seth Lederman: seth.lederman@tonix
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674175/pdf/vaccines-11-01682.pdf
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review: pathogenesis, review
NPRC/Institute: Primate Resources Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup-si, Jeonbuk, Korea; Korea National University of Science and Technology (UST), Daejeon, Korea.
Keywords: SARS-CoV-2, animal models, species sensitivity, other viruses, primates
Summary of Study: NHPs to combat COVID-19 and viral infectious disease outbreaks
References: PMID: 38084001 DOI: 10.1111/jmp.12689
Contact Info: Taeho Kwan: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1111/jmp.12689
NHP Species: multiple species
Year Published: 2023
Study Type/Review: pathogenesis, review
NPRC/Institute: Primate Resources Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup-si, Jeonbuk, Korea; Korea National University of Science and Technology (UST), Daejeon, Korea.
Keywords: SARS-CoV-2, animal models, species sensitivity, other viruses, primates
Summary of Study: NHPs to combat COVID-19 and viral infectious disease outbreaks
References: PMID: 38084001 DOI: 10.1111/jmp.12689
Contact Info: Taeho Kwan: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1111/jmp.12689
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland; Adimab LLC, Lebanon, New Hampshire; Invivyd, Inc., Waltham, Massachusetts; others
Keywords: SARS-CoV-2, Adintrevimab, prophylactics, viral load, pathology, hamsters, primates
Summary of Study: Monoclonal Antibody Adintrevimab Protects against COVID-19
References: doi: 10.1128/aac.01353-22
Contact Info: Kristin Narayan: [email protected]
URL: https://journals.asm.org/doi/10.1128/aac.01353-22
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland; Adimab LLC, Lebanon, New Hampshire; Invivyd, Inc., Waltham, Massachusetts; others
Keywords: SARS-CoV-2, Adintrevimab, prophylactics, viral load, pathology, hamsters, primates
Summary of Study: Monoclonal Antibody Adintrevimab Protects against COVID-19
References: doi: 10.1128/aac.01353-22
Contact Info: Kristin Narayan: [email protected]
URL: https://journals.asm.org/doi/10.1128/aac.01353-22
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: University of Oklahoma Health Sciences Center, Oklahoma City, OK USA and others.
Keywords: SARS-CoV-2, air–liquid interface, airway epithelium, immune response, innate immunity, inflammation, primates
Summary of Study: Isolation and in vitro differentiation of primary fetal baboon tracheal epithelial cells for studying host-virus Interactions
References: PMID: 37112842 / doi: 10.3390/v15040862
Contact Info: Matthew Walters: [email protected]
URL: https://www.mdpi.com/1999-4915/15/4/862
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: University of Oklahoma Health Sciences Center, Oklahoma City, OK USA and others.
Keywords: SARS-CoV-2, air–liquid interface, airway epithelium, immune response, innate immunity, inflammation, primates
Summary of Study: Isolation and in vitro differentiation of primary fetal baboon tracheal epithelial cells for studying host-virus Interactions
References: PMID: 37112842 / doi: 10.3390/v15040862
Contact Info: Matthew Walters: [email protected]
URL: https://www.mdpi.com/1999-4915/15/4/862
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Emory National Primate Research Center, Emory School of Medicine, others
Keywords: SARS-CoV-2, vaccine comparison, immune response, nasopharynx, primates
Summary of Study: Efficacy of mRNA-1273 and Novavax ancestral or BA.1 spike booster vaccines
References: doi: 10.1126/sciimmunol.adg7015
Contact Info: Rama Rao Amara: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.adg7015
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Emory National Primate Research Center, Emory School of Medicine, others
Keywords: SARS-CoV-2, vaccine comparison, immune response, nasopharynx, primates
Summary of Study: Efficacy of mRNA-1273 and Novavax ancestral or BA.1 spike booster vaccines
References: doi: 10.1126/sciimmunol.adg7015
Contact Info: Rama Rao Amara: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.adg7015
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Janssen Research and Development, Beerse, Belgium and Janssen Vaccines and Prevention B.V., Leiden, The Netherlands
Keywords: SARS-CoV-2, mechanistic modeling, vaccination, immune response, primates
Summary of Study: Humoral Immunity Following Ad26.COV2.S Vaccination
References: DOI: 10.1124/jpet.123.001591
Contact Info: Anna Dari: [email protected]
URL: https://jpet.aspetjournals.org/content/387/1/121.long
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Janssen Research and Development, Beerse, Belgium and Janssen Vaccines and Prevention B.V., Leiden, The Netherlands
Keywords: SARS-CoV-2, mechanistic modeling, vaccination, immune response, primates
Summary of Study: Humoral Immunity Following Ad26.COV2.S Vaccination
References: DOI: 10.1124/jpet.123.001591
Contact Info: Anna Dari: [email protected]
URL: https://jpet.aspetjournals.org/content/387/1/121.long
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Federal Medical-Biological Agency of Russia, Moscow, Russia; Saint Petersburg Scientific Research Institute of Vaccines and Serums of the Federal Medical-Biological Agency of Russia; others
Keywords: SARS-CoV-2, nucleocapsid, vaccine, immune response, primates
Summary of Study: Recombinant Nucleocapsid-Based Vaccine Convacell®
References: DOI: 10.3390/vaccines11040874
Contact Info: Sevastyan Rabdano: [email protected]
URL: https://www.mdpi.com/2076-393X/11/4/874
NHP Species: multiple species
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Federal Medical-Biological Agency of Russia, Moscow, Russia; Saint Petersburg Scientific Research Institute of Vaccines and Serums of the Federal Medical-Biological Agency of Russia; others
Keywords: SARS-CoV-2, nucleocapsid, vaccine, immune response, primates
Summary of Study: Recombinant Nucleocapsid-Based Vaccine Convacell®
References: DOI: 10.3390/vaccines11040874
Contact Info: Sevastyan Rabdano: [email protected]
URL: https://www.mdpi.com/2076-393X/11/4/874
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: therapeutics
NPRC/Institute: Oregon National Primate Research Center and numerous collaborators
Keywords: SARS-CoV-2, aerosol mAb, immune response, protection, primates
Summary of Study: Aerosol delivery of monoclonal antibodies limits viral replication and lung pathology
References: PMID: 37923717 PMCID: PMC10624670 DOI: 10.1038/s41467-023-42440-x
Contact Info: Nancy Haigwood: [email protected]
URL: https://www.nature.com/articles/s41467-023-42440-x
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: therapeutics
NPRC/Institute: Oregon National Primate Research Center and numerous collaborators
Keywords: SARS-CoV-2, aerosol mAb, immune response, protection, primates
Summary of Study: Aerosol delivery of monoclonal antibodies limits viral replication and lung pathology
References: PMID: 37923717 PMCID: PMC10624670 DOI: 10.1038/s41467-023-42440-x
Contact Info: Nancy Haigwood: [email protected]
URL: https://www.nature.com/articles/s41467-023-42440-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA, others
Keywords: SARS-CoV-2, intratracheal boosting, bivalent Ad26-based vaccine, immune response, primates
Summary of Study: Mucosal boosting enhances vaccine protection
References: PMID: 38096903 DOI: 10.1038/s41586-023-06951-3
Contact Info: Dan Barouch: [email protected]
URL: https://www.nature.com/articles/s41586-023-06951-3
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA, others
Keywords: SARS-CoV-2, intratracheal boosting, bivalent Ad26-based vaccine, immune response, primates
Summary of Study: Mucosal boosting enhances vaccine protection
References: PMID: 38096903 DOI: 10.1038/s41586-023-06951-3
Contact Info: Dan Barouch: [email protected]
URL: https://www.nature.com/articles/s41586-023-06951-3
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: The First Affiliated Hospital of Jinan University, Guangzhou 510630, China; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA USA
Keywords: SARS-CoV-2, favipiravir, biodistribution and pharmacokinetics, positron emission tomography, mice, primates
Summary of Study: Evaluating Favipiravir in rodents and nonhuman primates (NHP) with positron emission tomography
References: PMID: 37111280 / doi: 10.3390/ph16040524
Contact Info: Steven Liang: [email protected]
URL: https://www.mdpi.com/1424-8247/16/4/524
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: The First Affiliated Hospital of Jinan University, Guangzhou 510630, China; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA USA
Keywords: SARS-CoV-2, favipiravir, biodistribution and pharmacokinetics, positron emission tomography, mice, primates
Summary of Study: Evaluating Favipiravir in rodents and nonhuman primates (NHP) with positron emission tomography
References: PMID: 37111280 / doi: 10.3390/ph16040524
Contact Info: Steven Liang: [email protected]
URL: https://www.mdpi.com/1424-8247/16/4/524
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Virology and Immunology, Graduate School of Medicine, Osaka University, Osaka, 565-0871 Japan, others
Keywords: SARS-CoV-2, vaccine, Spike (S) receptor binding domain, immune response, primates
Summary of Study: saRNA vaccine expressing membrane-anchored RBD elicits broad and durable immunity
References: doi: 10.1038/s41467-023-38457-x
Contact Info: Takuya Yamamoto: [email protected]
URL: https://www.nature.com/articles/s41467-023-38457-x
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Virology and Immunology, Graduate School of Medicine, Osaka University, Osaka, 565-0871 Japan, others
Keywords: SARS-CoV-2, vaccine, Spike (S) receptor binding domain, immune response, primates
Summary of Study: saRNA vaccine expressing membrane-anchored RBD elicits broad and durable immunity
References: doi: 10.1038/s41467-023-38457-x
Contact Info: Takuya Yamamoto: [email protected]
URL: https://www.nature.com/articles/s41467-023-38457-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review: review
NPRC/Institute: Department de Sanitat i Anatomia Animals, Facultat de Veterinària, Campus de la UAB, Bellaterra, Spain; Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.; others
Keywords: SARS-CoV-2, review, animal models, neurological and neuropsychiatric symptoms, several species, primates
Summary of Study: Animal models to study neurological manifestations
References: DOI: 10.1038/s41684-023-01231-z
Contact Info: Joaquim Segalés: [email protected]
URL: https://www.nature.com/articles/s41684-023-01231-z
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review: review
NPRC/Institute: Department de Sanitat i Anatomia Animals, Facultat de Veterinària, Campus de la UAB, Bellaterra, Spain; Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.; others
Keywords: SARS-CoV-2, review, animal models, neurological and neuropsychiatric symptoms, several species, primates
Summary of Study: Animal models to study neurological manifestations
References: DOI: 10.1038/s41684-023-01231-z
Contact Info: Joaquim Segalés: [email protected]
URL: https://www.nature.com/articles/s41684-023-01231-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microbes and Infection, Fudan University, Shanghai, China
Keywords: SARS-CoV-2, fusion inhibitor, IgG-binding peptide, immune response, primates
Summary of Study: IgG Fc-Binding Peptide-Conjugated Pan-CoV Fusion Inhibitor Combined with Neutralizing Antibodies
References: DOI: 10.3390/biom13091283
Contact Info: Shibo Jiang:[email protected]; Shuai Xia: [email protected]
URL: https://www.mdpi.com/2218-273X/13/9/1283
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microbes and Infection, Fudan University, Shanghai, China
Keywords: SARS-CoV-2, fusion inhibitor, IgG-binding peptide, immune response, primates
Summary of Study: IgG Fc-Binding Peptide-Conjugated Pan-CoV Fusion Inhibitor Combined with Neutralizing Antibodies
References: DOI: 10.3390/biom13091283
Contact Info: Shibo Jiang:[email protected]; Shuai Xia: [email protected]
URL: https://www.mdpi.com/2218-273X/13/9/1283
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Novavax, Inc., Gaithersburg, MD, USA
Keywords: SARS-CoV-2, recombinant spike protein vaccine, immune response, mice, primates
Summary of Study: XBB.1.5 spike protein vaccine against EG.5.1 and emerging XBB variants
References: PMID: 37932354 PMCID: PMC10628164 DOI: 10.1038/s41598-023-46025-y
Contact Info: Gale Smith: [email protected]
URL: https://www.nature.com/articles/s41598-023-46025-y
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Novavax, Inc., Gaithersburg, MD, USA
Keywords: SARS-CoV-2, recombinant spike protein vaccine, immune response, mice, primates
Summary of Study: XBB.1.5 spike protein vaccine against EG.5.1 and emerging XBB variants
References: PMID: 37932354 PMCID: PMC10628164 DOI: 10.1038/s41598-023-46025-y
Contact Info: Gale Smith: [email protected]
URL: https://www.nature.com/articles/s41598-023-46025-y
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Core Unit of National Clinical Research Center for Laboratory Medicine Hefei Anhui P. R. China, others
Keywords: SARS-CoV-2, antibody response, immunological memory, long?term immune response, Omicron subvariants, primates
Summary of Study: Long-term immune response to Omicron-specific mRNA vaccination
References: PMID: 38107058 PMCID: PMC10724501 DOI: 10.1002/mco2.460
Contact Info: Wei Wang: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10724501/
NHP Species: multiple species
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Core Unit of National Clinical Research Center for Laboratory Medicine Hefei Anhui P. R. China, others
Keywords: SARS-CoV-2, antibody response, immunological memory, long?term immune response, Omicron subvariants, primates
Summary of Study: Long-term immune response to Omicron-specific mRNA vaccination
References: PMID: 38107058 PMCID: PMC10724501 DOI: 10.1002/mco2.460
Contact Info: Wei Wang: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10724501/
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Wayne State University, Detroit, Michigan, Center for Comparative Medicine, Massachusetts General Hospital, Boston, Massachusetts, Division of Animal Resources, University of Illinois at Urbana-Champaign, Champaign, Illinois
Keywords: SARS-CoV-2, review, neurological symptoms, humans, mice, hamsters, ferrets, primates
Summary of Study: Animal Models for the Study of Neurologic Manifestations Of COVID-19
References: doi: 10.30802/AALAS-CM-22-000073
Contact Info: Kelsey Carpenter: [email protected]
URL: https://www.ingentaconnect.com/content/aalas/cm/2023/00000073/00000001/art00006
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Wayne State University, Detroit, Michigan, Center for Comparative Medicine, Massachusetts General Hospital, Boston, Massachusetts, Division of Animal Resources, University of Illinois at Urbana-Champaign, Champaign, Illinois
Keywords: SARS-CoV-2, review, neurological symptoms, humans, mice, hamsters, ferrets, primates
Summary of Study: Animal Models for the Study of Neurologic Manifestations Of COVID-19
References: doi: 10.30802/AALAS-CM-22-000073
Contact Info: Kelsey Carpenter: [email protected]
URL: https://www.ingentaconnect.com/content/aalas/cm/2023/00000073/00000001/art00006
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Massachusetts General Hospital, Charlestown, Massachusetts USA; Brigham and Women's Hospital, Boston, Massachusetts, and others
Keywords: SARS-CoV-2, review, brain autopsies, neuropathological findings, humans, animal models, primates
Summary of Study: Review: What Can We Still Learn from Brain Autopsies in COVID-19?
References: PMID: 37023787 / doi: 10.1055/s-0043-1767716
Contact Info: Shibani Mukerji: [email protected]
URL: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-17677…
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Massachusetts General Hospital, Charlestown, Massachusetts USA; Brigham and Women's Hospital, Boston, Massachusetts, and others
Keywords: SARS-CoV-2, review, brain autopsies, neuropathological findings, humans, animal models, primates
Summary of Study: Review: What Can We Still Learn from Brain Autopsies in COVID-19?
References: PMID: 37023787 / doi: 10.1055/s-0043-1767716
Contact Info: Shibani Mukerji: [email protected]
URL: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-17677…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, 200438, China., many others
Keywords: SARS-CoV-2, vaccine, mRNA-based T-cell-inducing antigen, immune response, primates
Summary of Study: mRNA-based T-cell-inducing antigen strengthens COVID-19 vaccine
References: doi: 10.1038/s41467-023-38751-8
Contact Info: Jinzhong Lin: [email protected]
URL: https://www.nature.com/articles/s41467-023-38751-8
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, 200438, China., many others
Keywords: SARS-CoV-2, vaccine, mRNA-based T-cell-inducing antigen, immune response, primates
Summary of Study: mRNA-based T-cell-inducing antigen strengthens COVID-19 vaccine
References: doi: 10.1038/s41467-023-38751-8
Contact Info: Jinzhong Lin: [email protected]
URL: https://www.nature.com/articles/s41467-023-38751-8
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: prevention
NPRC/Institute: Graduate School of Medicine and Veterinary Medicine, University of Miyazaki, Miyazaki, 889-2155, Japan; Laboratory of Immunoregulation and Vaccine Research, Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Tsukuba, 305-0843, Japan.; others
Keywords: SARS-CoV-2, ACE2 decoy, immune response, pathology, mice, hamsters, primates
Summary of Study: Inhaled ACE2 decoy confers protection
References: DOI: 10.1126/scitranslmed.adi2623
Contact Info: Atsushi Hoshino: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.adi2623
NHP Species:
Year Published: 2023
Study Type/Review: prevention
NPRC/Institute: Graduate School of Medicine and Veterinary Medicine, University of Miyazaki, Miyazaki, 889-2155, Japan; Laboratory of Immunoregulation and Vaccine Research, Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Tsukuba, 305-0843, Japan.; others
Keywords: SARS-CoV-2, ACE2 decoy, immune response, pathology, mice, hamsters, primates
Summary of Study: Inhaled ACE2 decoy confers protection
References: DOI: 10.1126/scitranslmed.adi2623
Contact Info: Atsushi Hoshino: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.adi2623
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Executive Office, Shanghai BravoBio Co., Ltd., Shanghai, China; BravoVax Co., Ltd., Wuhan, China
Keywords: SARS-CoV-2, adenovirus vaccine, aerosol inhalation, immune response, primates
Summary of Study: Aerosol Inhalation of Chimpanzee Adenovirus Vectors (ChAd68) Expressing Ancestral or Omicron BA.1 Stabilized Pre-Fusion Spike Glycoproteins
References: DOI: 10.3390/vaccines11091427
Contact Info: Ke Wu: [email protected]
URL: https://www.mdpi.com/2076-393X/11/9/1427
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Executive Office, Shanghai BravoBio Co., Ltd., Shanghai, China; BravoVax Co., Ltd., Wuhan, China
Keywords: SARS-CoV-2, adenovirus vaccine, aerosol inhalation, immune response, primates
Summary of Study: Aerosol Inhalation of Chimpanzee Adenovirus Vectors (ChAd68) Expressing Ancestral or Omicron BA.1 Stabilized Pre-Fusion Spike Glycoproteins
References: DOI: 10.3390/vaccines11091427
Contact Info: Ke Wu: [email protected]
URL: https://www.mdpi.com/2076-393X/11/9/1427
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Cognitive and Neural Science Program, Department of Psychology, University of South Carolina, Columbia, SC, 29208, USA; others
Keywords: SARS-CoV-2, nervous system, pathophysiology, virus persistence, primates
Summary of Study: Viral persistence in central nervous system despite clinical recovery
References: PMID: 37934362 PMCID: PMC10630293 DOI: 10.1186/s43556-023-00153-z
Contact Info: Rosemarie Booze: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630293/
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Cognitive and Neural Science Program, Department of Psychology, University of South Carolina, Columbia, SC, 29208, USA; others
Keywords: SARS-CoV-2, nervous system, pathophysiology, virus persistence, primates
Summary of Study: Viral persistence in central nervous system despite clinical recovery
References: PMID: 37934362 PMCID: PMC10630293 DOI: 10.1186/s43556-023-00153-z
Contact Info: Rosemarie Booze: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630293/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: NIAID, NIH, Bethesda, MD 20892, USA.
Keywords: SARS-CoV-2, murine pneumonia virus-vectored vaccine, immune response, primates
Summary of Study: Intranasal murine pneumonia virus-vectored vaccine induces mucosal and serum antibodies
References: PMID: 38144450 PMCID: PMC10746510 DOI: 10.1016/j.isci.2023.108490
Contact Info: Ursula Buchholz: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2589004223025671?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: NIAID, NIH, Bethesda, MD 20892, USA.
Keywords: SARS-CoV-2, murine pneumonia virus-vectored vaccine, immune response, primates
Summary of Study: Intranasal murine pneumonia virus-vectored vaccine induces mucosal and serum antibodies
References: PMID: 38144450 PMCID: PMC10746510 DOI: 10.1016/j.isci.2023.108490
Contact Info: Ursula Buchholz: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2589004223025671?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: lemurs
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Department of Pharmacy, Faculty of Health Sciences, Universidad Cardenal Herrera-CEU, 46113 Valencia, Spain; others
Keywords: SARS-CoV-2, captive animals, one health, serological testing, primates
Summary of Study: Molecular and serological studies
References: PMID: 38200871 PMCID: PMC10778278 DOI: 10.3390/ani14010140
Contact Info: Consuelo Rubio-Guerri: [email protected]
URL: https://www.mdpi.com/2076-2615/14/1/140
NHP Species: lemurs
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Department of Pharmacy, Faculty of Health Sciences, Universidad Cardenal Herrera-CEU, 46113 Valencia, Spain; others
Keywords: SARS-CoV-2, captive animals, one health, serological testing, primates
Summary of Study: Molecular and serological studies
References: PMID: 38200871 PMCID: PMC10778278 DOI: 10.3390/ani14010140
Contact Info: Consuelo Rubio-Guerri: [email protected]
URL: https://www.mdpi.com/2076-2615/14/1/140
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Tulane NPRC; Duke University Medical Center
Keywords: SARS-CoV-2, prophylactic administration, convalescent plasma, disease progression and severity, primates
Summary of Study: Convalescent plasma administration results in suboptimal prophylaxis against SARS-CoV-2 infection
References: doi: 10.3389/fimmu.2023.1085883
Contact Info: Chad Roy: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1085883/full
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Tulane NPRC; Duke University Medical Center
Keywords: SARS-CoV-2, prophylactic administration, convalescent plasma, disease progression and severity, primates
Summary of Study: Convalescent plasma administration results in suboptimal prophylaxis against SARS-CoV-2 infection
References: doi: 10.3389/fimmu.2023.1085883
Contact Info: Chad Roy: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1085883/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Emory University, Emory National Primate Research Center, others
Keywords: SARS-CoV-2, innate immune system, airway inflammation, humans, primates
Summary of Study: TREM2+ and interstitial-like macrophages orchestrate airway inflammation
References: PMID: 37024448 / doi: 10.1038/s41467-023-37425-9
Contact Info: Mirko Paiardini: [email protected]
URL: https://www.nature.com/articles/s41467-023-37425-9
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Emory University, Emory National Primate Research Center, others
Keywords: SARS-CoV-2, innate immune system, airway inflammation, humans, primates
Summary of Study: TREM2+ and interstitial-like macrophages orchestrate airway inflammation
References: PMID: 37024448 / doi: 10.1038/s41467-023-37425-9
Contact Info: Mirko Paiardini: [email protected]
URL: https://www.nature.com/articles/s41467-023-37425-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Shulan International Medical College, Zhejiang Shuren University, Hangzhou, 310000, China, others
Keywords: SARS-CoV-2, inactivated vaccine, immune response, primates
Summary of Study: Delta (B.1.617.2) inactivated vaccine candidate elicits neutralizing antibodies
References: doi: 10.1016/j.virs.2023.05.009
Contact Info: Keda Chen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1995820X23000573?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Shulan International Medical College, Zhejiang Shuren University, Hangzhou, 310000, China, others
Keywords: SARS-CoV-2, inactivated vaccine, immune response, primates
Summary of Study: Delta (B.1.617.2) inactivated vaccine candidate elicits neutralizing antibodies
References: doi: 10.1016/j.virs.2023.05.009
Contact Info: Keda Chen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1995820X23000573?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: KRIBB School of Bioscience, Korea University of Science & Technology (UST), Daejeon, Republic of Korea; National Primate Research Centre, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Chungcheongbuk, Republic of Korea.; others
Keywords: SARS-CoV-2, spatial transcriptome atlas, lungs, immune response, primates
Summary of Study: Pulmonary microstructure-specific COVID-19 gene signatures
References: DOI: 10.1038/s42003-023-05253-8
Contact Info: Jung Joo Hong: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462721/
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: KRIBB School of Bioscience, Korea University of Science & Technology (UST), Daejeon, Republic of Korea; National Primate Research Centre, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Chungcheongbuk, Republic of Korea.; others
Keywords: SARS-CoV-2, spatial transcriptome atlas, lungs, immune response, primates
Summary of Study: Pulmonary microstructure-specific COVID-19 gene signatures
References: DOI: 10.1038/s42003-023-05253-8
Contact Info: Jung Joo Hong: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462721/
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: University of South Carolina; Tulane National Primate Research Center
Keywords: SARS-CoV-2, brain, pathology, in situ hybridization, primates
Summary of Study: SARS-CoV-2 RNA Persists in the Central Nervous System despite clinical recovery
References: DOI: 10.1101/2023.08.29.555368
Contact Info: Rosemarie Booze: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491216/
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: University of South Carolina; Tulane National Primate Research Center
Keywords: SARS-CoV-2, brain, pathology, in situ hybridization, primates
Summary of Study: SARS-CoV-2 RNA Persists in the Central Nervous System despite clinical recovery
References: DOI: 10.1101/2023.08.29.555368
Contact Info: Rosemarie Booze: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491216/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD 20892, USA; others
Keywords: SARS-CoV-2, Adenoviral-vectored Vaccine Boosting, immune response, primates
Summary of Study: Mucosal adenoviral-vectored vaccine boosting prevents XBB.1.16 infection
References: bioRxiv. 2023 Nov 8:2023.11.06.565765. doi: 10.1101/2023.11.06.565765. Preprint. PMID: 37986823 PMCID: PMC10659340 DOI: 10.1101/2023.11.06.565765
Contact Info: Daniel Douek: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.11.06.565765v1
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD 20892, USA; others
Keywords: SARS-CoV-2, Adenoviral-vectored Vaccine Boosting, immune response, primates
Summary of Study: Mucosal adenoviral-vectored vaccine boosting prevents XBB.1.16 infection
References: bioRxiv. 2023 Nov 8:2023.11.06.565765. doi: 10.1101/2023.11.06.565765. Preprint. PMID: 37986823 PMCID: PMC10659340 DOI: 10.1101/2023.11.06.565765
Contact Info: Daniel Douek: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.11.06.565765v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Shanghai Institute for Advanced Immunochemical Studies, School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510300, P. R. China, many others
Keywords: SARS-CoV-2, mosaic RBD nanoparticle vaccine, immune response, primates
Summary of Study: Mosaic RBD nanoparticles elicit protective immunity
References: PMID: 38105421 DOI: 10.1002/advs.202303366
Contact Info: Jincun Zhao: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10916629/
NHP Species: cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Shanghai Institute for Advanced Immunochemical Studies, School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510300, P. R. China, many others
Keywords: SARS-CoV-2, mosaic RBD nanoparticle vaccine, immune response, primates
Summary of Study: Mosaic RBD nanoparticles elicit protective immunity
References: PMID: 38105421 DOI: 10.1002/advs.202303366
Contact Info: Jincun Zhao: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10916629/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; Gilead Sciences
Keywords: SARS-CoV-2, Remdesivir, subcutaneous administration, pathology, virus load, primates
Summary of Study: Early subcutaneous administration of remdesivir can protect from lower respiratory tract disease caused by SARS-CoV-2.
References: PMID: 35032523 / doi: 10.1016/j.antiviral.2022.105246
Contact Info: Emmie de Wit: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0166354222000146?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; Gilead Sciences
Keywords: SARS-CoV-2, Remdesivir, subcutaneous administration, pathology, virus load, primates
Summary of Study: Early subcutaneous administration of remdesivir can protect from lower respiratory tract disease caused by SARS-CoV-2.
References: PMID: 35032523 / doi: 10.1016/j.antiviral.2022.105246
Contact Info: Emmie de Wit: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0166354222000146?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Janssen Vaccines and Prevention; Ragon Institute of MGH, MIT and Harvard; BIOQUAL; Amsterdam University Medical Center
Keywords: SARS-CoV-2, homologous or variant booster vaccine, humoral and cellular immune responses, primates
Summary of Study: A late boost with Ad26.COV2.S or Ad26.COV2.S.351 resulted in a marked increase in humoral and cellular immune responses that were highly cross-reactive across multiple SARS-CoV-2 variants in rhesus macaques.
References: PMID: 35191769 / doi: 10.1126/scitranslmed.bm4996
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abm4996?rfr_dat=cr_pub%20…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Janssen Vaccines and Prevention; Ragon Institute of MGH, MIT and Harvard; BIOQUAL; Amsterdam University Medical Center
Keywords: SARS-CoV-2, homologous or variant booster vaccine, humoral and cellular immune responses, primates
Summary of Study: A late boost with Ad26.COV2.S or Ad26.COV2.S.351 resulted in a marked increase in humoral and cellular immune responses that were highly cross-reactive across multiple SARS-CoV-2 variants in rhesus macaques.
References: PMID: 35191769 / doi: 10.1126/scitranslmed.bm4996
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abm4996?rfr_dat=cr_pub%20…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre; Department of Pathology, Amsterdam UMC; Utrecht University; Leiden University Medical Center; University of Twente
Keywords: SARS-CoV-2, neuropathology, immune response, primates
Summary of Study: Data highlight the potential of SARS-CoV-2 to cause pathology in the brain of macaques. A range of neurological abnormalities were observed, including hypermetabolic pituitary gland, alpha-synuclein inclusions, activated microglia in the brain parenchyma, and infiltrating T-cells.
References: PMID: 35458506 / doi: 10.3390/v14040776
Contact Info: Ernst Verschoor: [email protected]
URL: https://www.mdpi.com/1999-4915/14/4/776
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre; Department of Pathology, Amsterdam UMC; Utrecht University; Leiden University Medical Center; University of Twente
Keywords: SARS-CoV-2, neuropathology, immune response, primates
Summary of Study: Data highlight the potential of SARS-CoV-2 to cause pathology in the brain of macaques. A range of neurological abnormalities were observed, including hypermetabolic pituitary gland, alpha-synuclein inclusions, activated microglia in the brain parenchyma, and infiltrating T-cells.
References: PMID: 35458506 / doi: 10.3390/v14040776
Contact Info: Ernst Verschoor: [email protected]
URL: https://www.mdpi.com/1999-4915/14/4/776
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, protocols, animal models, immunology, primates
Summary of Study: This book describes the different aspects of modelling the SARS-CoV-2 infection in NHPs along with the associated methods used in immunology.
References: PMID: 35554911 / doi. 10.1007/978-1-2111-0_15
Contact Info: Deepak Kaushal: [email protected]
URL: https://link.springer.com/protocol/10.1007/978-1-0716-2111-0_15
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, protocols, animal models, immunology, primates
Summary of Study: This book describes the different aspects of modelling the SARS-CoV-2 infection in NHPs along with the associated methods used in immunology.
References: PMID: 35554911 / doi. 10.1007/978-1-2111-0_15
Contact Info: Deepak Kaushal: [email protected]
URL: https://link.springer.com/protocol/10.1007/978-1-0716-2111-0_15
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Institute of Zoonosis, and College of Veterinary Medicine, Jilin University; Chinese Academy of Medicine Sciences & Peking Union Medical College; Walvax Biotechnology Co., Ltd; Inner Mongolia University for Nationalities; Chinese Academy of Agricultural Sciences; Yuxi JOZO Biotechnology co., LTD; Tongji Medical College, Huazhong University of Science and Technology
Keywords: SARS-CoV-2, equine immunoglobulin, anti virus efficacy, histopathology, immune response, primates
Summary of Study: Therapeutic-grade equine immunoglobins are effective at improving the clinical symptoms of those hospitalized with SARS-CoV-2 and can be rapidly developed.
References: PMID: 35798694 / doi: 10.1038/s41392-022-01095-8
Contact Info: Zhongping Xie: [email protected]; Ningyi Jin: [email protected]; Mingyuan Liu: [email protected]
URL: https://www.nature.com/articles/s41392-022-01095-8
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Institute of Zoonosis, and College of Veterinary Medicine, Jilin University; Chinese Academy of Medicine Sciences & Peking Union Medical College; Walvax Biotechnology Co., Ltd; Inner Mongolia University for Nationalities; Chinese Academy of Agricultural Sciences; Yuxi JOZO Biotechnology co., LTD; Tongji Medical College, Huazhong University of Science and Technology
Keywords: SARS-CoV-2, equine immunoglobulin, anti virus efficacy, histopathology, immune response, primates
Summary of Study: Therapeutic-grade equine immunoglobins are effective at improving the clinical symptoms of those hospitalized with SARS-CoV-2 and can be rapidly developed.
References: PMID: 35798694 / doi: 10.1038/s41392-022-01095-8
Contact Info: Zhongping Xie: [email protected]; Ningyi Jin: [email protected]; Mingyuan Liu: [email protected]
URL: https://www.nature.com/articles/s41392-022-01095-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences & Peking Union Medical College; Kunming No.1 High School; Kunming National High-level Biosafety Primate Research Center
Keywords: SARS-CoV-2, vaccines, repertoire diversities of B cells and T cells, whole-virus inactivated and S1 protein subunit vaccine, primates
Summary of Study: Comparison of B-cell and T-cell responses between a whole-virus inactivated vaccine and an S1 protein subunit vaccine.
References: PMID: 36070519 / doi: 10.1080/21645515.2022.2118477
Contact Info: Huiwen Zheng: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/21645515.2022.2118477
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences & Peking Union Medical College; Kunming No.1 High School; Kunming National High-level Biosafety Primate Research Center
Keywords: SARS-CoV-2, vaccines, repertoire diversities of B cells and T cells, whole-virus inactivated and S1 protein subunit vaccine, primates
Summary of Study: Comparison of B-cell and T-cell responses between a whole-virus inactivated vaccine and an S1 protein subunit vaccine.
References: PMID: 36070519 / doi: 10.1080/21645515.2022.2118477
Contact Info: Huiwen Zheng: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/21645515.2022.2118477
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Shiga University of Medical Science, Otsu, Japan; others
Keywords: SARS-CoV-2, vaccine development, attenuated vaccinia virus, immune response, proteomics, virus variants, mice, primates
Summary of Study: Vaccine protects monkeys and transgenic mice from SARS-CoV-2 and variants
References: doi: 10.3389/fmicb.2022.967019
Contact Info: Michinori Kohara: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2022.967019/full
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Shiga University of Medical Science, Otsu, Japan; others
Keywords: SARS-CoV-2, vaccine development, attenuated vaccinia virus, immune response, proteomics, virus variants, mice, primates
Summary of Study: Vaccine protects monkeys and transgenic mice from SARS-CoV-2 and variants
References: doi: 10.3389/fmicb.2022.967019
Contact Info: Michinori Kohara: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2022.967019/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; Yerkes National Primate Research Center; Emory University School of Medicine; Bioqual; Moderna, Inc.
Keywords: SARS-CoV-2, mRNA-1273 vaccination, longitudinal study, immune response, primates
Summary of Study: While mRNA-1273 provided durable protection against B.1.617.2 challenge, control of the virus was briefly delayed in the lungs and limited in the nose, which may provide the virus with a greater opportunity for transmission.
References: PMID: 34921774 / doi: 10.1016/j.cell.2021.12.002
Contact Info: Robert Seder: [email protected]; Daniel Douek: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0092867421014057?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; Yerkes National Primate Research Center; Emory University School of Medicine; Bioqual; Moderna, Inc.
Keywords: SARS-CoV-2, mRNA-1273 vaccination, longitudinal study, immune response, primates
Summary of Study: While mRNA-1273 provided durable protection against B.1.617.2 challenge, control of the virus was briefly delayed in the lungs and limited in the nose, which may provide the virus with a greater opportunity for transmission.
References: PMID: 34921774 / doi: 10.1016/j.cell.2021.12.002
Contact Info: Robert Seder: [email protected]; Daniel Douek: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0092867421014057?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medicine Sciences & Peking Union Medical College; National Institute for Viral Disease Control and Prevention
Keywords: SARS-CoV-2, heterologous vaccines, intradermal administration, immune response, primates
Summary of Study: This study reports a new heterologous prime-boost strategy of intradermal immunization with the inactivated vaccine and K-S antigen. This strategy can significantly increase the neutralizing antibody titers and promote specific T cell responses in mice and macaques.
References: PMID: 34931939 / doi: 10.1080/22221751.2021807https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
Contact Info: Wenbo Xu: [email protected]; Qihan Li: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medicine Sciences & Peking Union Medical College; National Institute for Viral Disease Control and Prevention
Keywords: SARS-CoV-2, heterologous vaccines, intradermal administration, immune response, primates
Summary of Study: This study reports a new heterologous prime-boost strategy of intradermal immunization with the inactivated vaccine and K-S antigen. This strategy can significantly increase the neutralizing antibody titers and promote specific T cell responses in mice and macaques.
References: PMID: 34931939 / doi: 10.1080/22221751.2021807https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
Contact Info: Wenbo Xu: [email protected]; Qihan Li: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine
Keywords: SARS-CoV-2, virus genome, gut, virus evolution, primates
Summary of Study: Previous reports that an intact furin cleavage site is important for infection in vivo were confirmed in this study. Additionally, three mutations were identified that may represent an adaptation of SARS-CoV2 to African green monkeys or to NHP generally.
References: PMID: 35062281 / doi: 10.3390/v14010077
Contact Info: Nicholas Maness: [email protected]
URL: https://www.mdpi.com/1999-4915/14/1/77
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine
Keywords: SARS-CoV-2, virus genome, gut, virus evolution, primates
Summary of Study: Previous reports that an intact furin cleavage site is important for infection in vivo were confirmed in this study. Additionally, three mutations were identified that may represent an adaptation of SARS-CoV2 to African green monkeys or to NHP generally.
References: PMID: 35062281 / doi: 10.3390/v14010077
Contact Info: Nicholas Maness: [email protected]
URL: https://www.mdpi.com/1999-4915/14/1/77
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Shanghai Jiao Tong University; Westlake University, Hangzhou; University of Texas; Jecho Biopharmaceuticals; Jecho Laboratories; Zhengzhou University People's Hospital
Keywords: SARS-CoV-2, virus variants, neutralizing monoclonal antibodies, immune response, mice, primates
Summary of Study: An antibody designated as 2G1 efficiently neutralized all VOCs including widely spread Alpha, Beta, Gamma, Delta variants and Cluster 5, a variant with Y453F substitution that once caused public concern due to its zoonotic characteristics.
References: PMID: 35169121 / doi: 10.1038/s41421-022-00381-7
Contact Info: Lei Han: [email protected]
URL: https://www.nature.com/articles/s41421-022-00381-7
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Shanghai Jiao Tong University; Westlake University, Hangzhou; University of Texas; Jecho Biopharmaceuticals; Jecho Laboratories; Zhengzhou University People's Hospital
Keywords: SARS-CoV-2, virus variants, neutralizing monoclonal antibodies, immune response, mice, primates
Summary of Study: An antibody designated as 2G1 efficiently neutralized all VOCs including widely spread Alpha, Beta, Gamma, Delta variants and Cluster 5, a variant with Y453F substitution that once caused public concern due to its zoonotic characteristics.
References: PMID: 35169121 / doi: 10.1038/s41421-022-00381-7
Contact Info: Lei Han: [email protected]
URL: https://www.nature.com/articles/s41421-022-00381-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Peking University; Chinese Academy of Medical Sciences and Peking Union Medical College; WHO Collaborating Center for Standardization and Evaluation of Biologicals
Keywords: SARS-CoV-2, circRNA vaccine, neutralizing antibodies, virus variants, primates
Summary of Study: CircRNA/RBD-Omicron vaccine induced effective neutralizing antibodies against the Omicron but not the Delta variant. In contrast, the circRNA/RBD-Delta vaccine protected against both Delta and Omicron or functioned as a booster after two doses of either native- or Delta-specific vaccination, making it a favorable choice against the current variants of concern of SARS-CoV-2.
References: PMID: 35460644 / doi: 10.1016/j.cell.2022.03.044
Contact Info: Wensheng Wei: [email protected]
URL: https://www.cell.com/cell/fulltext/S0092-8674(22)00394-4?_returnURL=https%3A//l…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Peking University; Chinese Academy of Medical Sciences and Peking Union Medical College; WHO Collaborating Center for Standardization and Evaluation of Biologicals
Keywords: SARS-CoV-2, circRNA vaccine, neutralizing antibodies, virus variants, primates
Summary of Study: CircRNA/RBD-Omicron vaccine induced effective neutralizing antibodies against the Omicron but not the Delta variant. In contrast, the circRNA/RBD-Delta vaccine protected against both Delta and Omicron or functioned as a booster after two doses of either native- or Delta-specific vaccination, making it a favorable choice against the current variants of concern of SARS-CoV-2.
References: PMID: 35460644 / doi: 10.1016/j.cell.2022.03.044
Contact Info: Wensheng Wei: [email protected]
URL: https://www.cell.com/cell/fulltext/S0092-8674(22)00394-4?_returnURL=https%3A//l…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: SUNY Upstate Medical University; Walter Reed Army Institute of Research; NIAID
Keywords: SARS-CoV-2, mRNA-1273 vaccine, respiratory tract, inflammation, primates
Summary of Study: This study defines the lower respiratory tract cellular and transcriptional signature associated with SARS-CoV-2 in macaques using two distinct viral variants, and identifies conserved signatures of vaccine-elicited protection from infection-attendant inflammation. These date emphasize the contribution of inflammatory/migratory DCs and macrophages to lower respiratory tract inflammation following SARS-CoV-2 infection, and define a critical relationship between antibody titers, post-challenge viral burden, and broad infection-elicited inflammation.
References: PMID: 35653196 / doi: 10.1172/jci.insight.160039
Contact Info: Robert Seder: Robert Seder: [email protected]
URL: https://insight.jci.org/articles/view/160039
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: SUNY Upstate Medical University; Walter Reed Army Institute of Research; NIAID
Keywords: SARS-CoV-2, mRNA-1273 vaccine, respiratory tract, inflammation, primates
Summary of Study: This study defines the lower respiratory tract cellular and transcriptional signature associated with SARS-CoV-2 in macaques using two distinct viral variants, and identifies conserved signatures of vaccine-elicited protection from infection-attendant inflammation. These date emphasize the contribution of inflammatory/migratory DCs and macrophages to lower respiratory tract inflammation following SARS-CoV-2 infection, and define a critical relationship between antibody titers, post-challenge viral burden, and broad infection-elicited inflammation.
References: PMID: 35653196 / doi: 10.1172/jci.insight.160039
Contact Info: Robert Seder: Robert Seder: [email protected]
URL: https://insight.jci.org/articles/view/160039
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Gritstone bio, Inc.; Battelle Biomedical Research Center
Keywords: SARS-CoV-2, self-amplifying mRNA vaccine, immune response, primates
Summary of Study: Report of the preclinical development of a strong self-amplifying mRNA (SAM) vaccine being evaluated in clinical trials as both a homologous prime-boost regimen at low doses and as a boost following heterologous prime
References: PMID: 35672369 PMCID: PMC9173840 DOI: 10.1038/s41467-022-31005-z
Contact Info: Karin Jooss: [email protected]
URL: https://www.nature.com/articles/s41467-022-31005-z
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Gritstone bio, Inc.; Battelle Biomedical Research Center
Keywords: SARS-CoV-2, self-amplifying mRNA vaccine, immune response, primates
Summary of Study: Report of the preclinical development of a strong self-amplifying mRNA (SAM) vaccine being evaluated in clinical trials as both a homologous prime-boost regimen at low doses and as a boost following heterologous prime
References: PMID: 35672369 PMCID: PMC9173840 DOI: 10.1038/s41467-022-31005-z
Contact Info: Karin Jooss: [email protected]
URL: https://www.nature.com/articles/s41467-022-31005-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Center for Genetic Engineering and Biotechnology; Civilian Defense Scienti?c Research Center, Carretera de Jamaica y Autopista Nacional; Biotechnology and Pharmaceutical Industries Group, BioCubaFarma, Ave; Latin American School of Medicine
Keywords: SARS-CoV-2, vaccine, yeast, manufacturing, mice, primates
Summary of Study: The COVID-19 receptor-binding domain produced in yeast cells can be modified by adding amino acids in order to create a possible vaccine candidate due to its ability to stimulate anti-inflammatory cells and inhibit binding to ACE2.
References: PMID: 35953030 / doi: 10.1016/j.nbt.2022.08.002
Contact Info: Gerardo Guillén-Nieto: Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Ave. 31 E/ 158 y 190, La Habana 10600, Cuba
URL: https://www.sciencedirect.com/science/article/pii/S1871678422000462?via%3Dihub=
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Center for Genetic Engineering and Biotechnology; Civilian Defense Scienti?c Research Center, Carretera de Jamaica y Autopista Nacional; Biotechnology and Pharmaceutical Industries Group, BioCubaFarma, Ave; Latin American School of Medicine
Keywords: SARS-CoV-2, vaccine, yeast, manufacturing, mice, primates
Summary of Study: The COVID-19 receptor-binding domain produced in yeast cells can be modified by adding amino acids in order to create a possible vaccine candidate due to its ability to stimulate anti-inflammatory cells and inhibit binding to ACE2.
References: PMID: 35953030 / doi: 10.1016/j.nbt.2022.08.002
Contact Info: Gerardo Guillén-Nieto: Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Ave. 31 E/ 158 y 190, La Habana 10600, Cuba
URL: https://www.sciencedirect.com/science/article/pii/S1871678422000462?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital; National Kunming High-level Biosafety Primate Research Center; Nagasaki University; Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, self-assembled trimeric protein vaccine, virus variants, mice, primates
Summary of Study: A self-assembled trimeric protein made from linking a sequence from the Delta variant and a subunit in SARS-CoV-2 shows a strong immune response against Omicron variants.
References: PMID: 36115859 / doi: 10.1038/s41467-022-33209-9
Contact Info: Xiangrong Song: [email protected]; Shuaiyao Lu: [email protected]; Xiaozhong Peng: [email protected]; Guangwen Lu: [email protected]; Xiawei Wei: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482656/
NHP Species: multiple species
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital; National Kunming High-level Biosafety Primate Research Center; Nagasaki University; Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, self-assembled trimeric protein vaccine, virus variants, mice, primates
Summary of Study: A self-assembled trimeric protein made from linking a sequence from the Delta variant and a subunit in SARS-CoV-2 shows a strong immune response against Omicron variants.
References: PMID: 36115859 / doi: 10.1038/s41467-022-33209-9
Contact Info: Xiangrong Song: [email protected]; Shuaiyao Lu: [email protected]; Xiaozhong Peng: [email protected]; Guangwen Lu: [email protected]; Xiawei Wei: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482656/