Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Vaccine Research Center, NIAID, NIH, Bethesda, MD, 20892, USA
Keywords: SARS-CoV-2, mRNA vaccine, immune response, single-cell sequencing, transcriptomics, primates
Summary of Study: Interaction dynamics between innate and adaptive immune cells responding to vaccine
References: PMID: 38042809 PMCID: PMC10693617 DOI: 10.1038/s41467-023-43420-x
Contact Info: Daniel Douek: [email protected]
URL: https://www.nature.com/articles/s41467-023-43420-x
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Vaccine Research Center, NIAID, NIH, Bethesda, MD, 20892, USA
Keywords: SARS-CoV-2, mRNA vaccine, immune response, single-cell sequencing, transcriptomics, primates
Summary of Study: Interaction dynamics between innate and adaptive immune cells responding to vaccine
References: PMID: 38042809 PMCID: PMC10693617 DOI: 10.1038/s41467-023-43420-x
Contact Info: Daniel Douek: [email protected]
URL: https://www.nature.com/articles/s41467-023-43420-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Neurobiology and Aging, Biomedical Primate Research Centre (BPRC), Lange Kleiweg 161, 2288GJ, Rijswijk, The Netherlands; others
Keywords: SARS-CoV-2, neuroinflammation, positron emission tomography, brain, primates
Summary of Study: Widespread neuroinflammation in SARS-CoV-2 infection
References: DOI: 10.1186/s12974-023-02857-z
Contact Info: Jinte Middeldorp: [email protected]
URL: https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-023-02857-z
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Neurobiology and Aging, Biomedical Primate Research Centre (BPRC), Lange Kleiweg 161, 2288GJ, Rijswijk, The Netherlands; others
Keywords: SARS-CoV-2, neuroinflammation, positron emission tomography, brain, primates
Summary of Study: Widespread neuroinflammation in SARS-CoV-2 infection
References: DOI: 10.1186/s12974-023-02857-z
Contact Info: Jinte Middeldorp: [email protected]
URL: https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-023-02857-z
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Chulalongkorn University, Bangkok, Thailand and others
Keywords: SARS-CoV-2, recombinant plant-based RBD vaccine, immunogenicity, efficacy, safety, mice, primates
Summary of Study: Recombinant plant based RBD vaccine formulated with 3M-052-Alum adjuvant
References: PMID: 36963999 / doi: 10.1016/j.vaccine.2023.03.027
Contact Info: Waranyoo Phoolcharoen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003122?via%3Dihub=
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Chulalongkorn University, Bangkok, Thailand and others
Keywords: SARS-CoV-2, recombinant plant-based RBD vaccine, immunogenicity, efficacy, safety, mice, primates
Summary of Study: Recombinant plant based RBD vaccine formulated with 3M-052-Alum adjuvant
References: PMID: 36963999 / doi: 10.1016/j.vaccine.2023.03.027
Contact Info: Waranyoo Phoolcharoen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003122?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: lemurs
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Department of Pharmacy, Faculty of Health Sciences, Universidad Cardenal Herrera-CEU, 46113 Valencia, Spain; others
Keywords: SARS-CoV-2, captive animals, one health, serological testing, primates
Summary of Study: Molecular and serological studies
References: PMID: 38200871 PMCID: PMC10778278 DOI: 10.3390/ani14010140
Contact Info: Consuelo Rubio-Guerri: [email protected]
URL: https://www.mdpi.com/2076-2615/14/1/140
NHP Species: lemurs
Year Published: 2023
Study Type/Review: pathogenesis
NPRC/Institute: Department of Pharmacy, Faculty of Health Sciences, Universidad Cardenal Herrera-CEU, 46113 Valencia, Spain; others
Keywords: SARS-CoV-2, captive animals, one health, serological testing, primates
Summary of Study: Molecular and serological studies
References: PMID: 38200871 PMCID: PMC10778278 DOI: 10.3390/ani14010140
Contact Info: Consuelo Rubio-Guerri: [email protected]
URL: https://www.mdpi.com/2076-2615/14/1/140
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Federal Medical-Biological Agency of Russia, Moscow, Russia; Saint Petersburg Scientific Research Institute of Vaccines and Serums of the Federal Medical-Biological Agency of Russia; others
Keywords: SARS-CoV-2, nucleocapsid, vaccine, immune response, primates
Summary of Study: Recombinant Nucleocapsid-Based Vaccine Convacell®
References: DOI: 10.3390/vaccines11040874
Contact Info: Sevastyan Rabdano: [email protected]
URL: https://www.mdpi.com/2076-393X/11/4/874
NHP Species: multiple species
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Federal Medical-Biological Agency of Russia, Moscow, Russia; Saint Petersburg Scientific Research Institute of Vaccines and Serums of the Federal Medical-Biological Agency of Russia; others
Keywords: SARS-CoV-2, nucleocapsid, vaccine, immune response, primates
Summary of Study: Recombinant Nucleocapsid-Based Vaccine Convacell®
References: DOI: 10.3390/vaccines11040874
Contact Info: Sevastyan Rabdano: [email protected]
URL: https://www.mdpi.com/2076-393X/11/4/874
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Vaxxinity, Inc., Merritt Island, FL, USA; University of Texas Medical Branch, Galveston, TX, USA; others
Keywords: SARS-CoV-2, subunit vaccine, Fc-mediated effector function, immune response, primates
Summary of Study: RBD-Protein/Peptide Vaccine UB-612 Elicits Mucosal and Fc-Mediated Antibody Responses
References: PMID: 38250853 PMCID: PMC10818657 DOI: 10.3390/vaccines12010040
Contact Info: Shixia Wang: [email protected]
URL: https://www.mdpi.com/2076-393X/12/1/40
NHP Species: cynomolgus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Vaxxinity, Inc., Merritt Island, FL, USA; University of Texas Medical Branch, Galveston, TX, USA; others
Keywords: SARS-CoV-2, subunit vaccine, Fc-mediated effector function, immune response, primates
Summary of Study: RBD-Protein/Peptide Vaccine UB-612 Elicits Mucosal and Fc-Mediated Antibody Responses
References: PMID: 38250853 PMCID: PMC10818657 DOI: 10.3390/vaccines12010040
Contact Info: Shixia Wang: [email protected]
URL: https://www.mdpi.com/2076-393X/12/1/40
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Veterinary Research Institute, Lahore, Pakistan; Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan; others
Keywords: SARS-CoV-2, inactivated vaccine, efficacy, immunogenicity, virus variant, rabbits, primates
Summary of Study: Molecular characterization and selection of delta variant for vaccine
References: doi: 10.3390/vaccines11030607
Contact Info: Tahir Yaqub: [email protected]
URL: https://www.mdpi.com/2076-393X/11/3/607
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Veterinary Research Institute, Lahore, Pakistan; Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan; others
Keywords: SARS-CoV-2, inactivated vaccine, efficacy, immunogenicity, virus variant, rabbits, primates
Summary of Study: Molecular characterization and selection of delta variant for vaccine
References: doi: 10.3390/vaccines11030607
Contact Info: Tahir Yaqub: [email protected]
URL: https://www.mdpi.com/2076-393X/11/3/607
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Wayne State University, Detroit, Michigan, Center for Comparative Medicine, Massachusetts General Hospital, Boston, Massachusetts, Division of Animal Resources, University of Illinois at Urbana-Champaign, Champaign, Illinois
Keywords: SARS-CoV-2, review, neurological symptoms, humans, mice, hamsters, ferrets, primates
Summary of Study: Animal Models for the Study of Neurologic Manifestations Of COVID-19
References: doi: 10.30802/AALAS-CM-22-000073
Contact Info: Kelsey Carpenter: [email protected]
URL: https://aalas.kglmeridian.com/view/journals/72010023/73/1/article-p91.xml
NHP Species: multiple species
Year Published: 2023
Study Type/Review:
NPRC/Institute: Wayne State University, Detroit, Michigan, Center for Comparative Medicine, Massachusetts General Hospital, Boston, Massachusetts, Division of Animal Resources, University of Illinois at Urbana-Champaign, Champaign, Illinois
Keywords: SARS-CoV-2, review, neurological symptoms, humans, mice, hamsters, ferrets, primates
Summary of Study: Animal Models for the Study of Neurologic Manifestations Of COVID-19
References: doi: 10.30802/AALAS-CM-22-000073
Contact Info: Kelsey Carpenter: [email protected]
URL: https://aalas.kglmeridian.com/view/journals/72010023/73/1/article-p91.xml
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland; Adimab LLC, Lebanon, New Hampshire; Invivyd, Inc., Waltham, Massachusetts; others
Keywords: SARS-CoV-2, Adintrevimab, prophylactics, viral load, pathology, hamsters, primates
Summary of Study: Monoclonal Antibody Adintrevimab Protects against COVID-19
References: doi: 10.1128/aac.01353-22
Contact Info: Kristin Narayan: [email protected]
URL: https://journals.asm.org/doi/10.1128/aac.01353-22
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland; Adimab LLC, Lebanon, New Hampshire; Invivyd, Inc., Waltham, Massachusetts; others
Keywords: SARS-CoV-2, Adintrevimab, prophylactics, viral load, pathology, hamsters, primates
Summary of Study: Monoclonal Antibody Adintrevimab Protects against COVID-19
References: doi: 10.1128/aac.01353-22
Contact Info: Kristin Narayan: [email protected]
URL: https://journals.asm.org/doi/10.1128/aac.01353-22
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Vaxine Pty Ltd., Warradale, Australia; Flinders University, Bedford Park, Australia; others
Keywords: SARS-CoV-2, spike protein, adjuvanted vaccine, immune response, primates
Summary of Study: Advax-CpG55.2™ adjuvanted recombinant spike protein vaccine protects cynomolgus macaques from a homologous SARS-CoV-2 virus challenge.
References: DOI: 10.1016/j.vaccine.2023.06.063
Contact Info: Nikolai Petrovsky: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X2300748X?via%3Dihub=
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Vaxine Pty Ltd., Warradale, Australia; Flinders University, Bedford Park, Australia; others
Keywords: SARS-CoV-2, spike protein, adjuvanted vaccine, immune response, primates
Summary of Study: Advax-CpG55.2™ adjuvanted recombinant spike protein vaccine protects cynomolgus macaques from a homologous SARS-CoV-2 virus challenge.
References: DOI: 10.1016/j.vaccine.2023.06.063
Contact Info: Nikolai Petrovsky: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X2300748X?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Biosystems, Laboratory of Gene Technology, KU Leuven, Leuven Belgium
Keywords: SARS-CoV-2, review, vaccine development, mice, hamsters, primates
Summary of Study: Do we need nasal vaccines against COVID 19
References: doi: 10.1111/1751-7915.14181
Contact Info: Harald Brüssow: [email protected]
URL: https://ami-journals.onlinelibrary.wiley.com/doi/full/10.1111/1751-7915.14181
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Biosystems, Laboratory of Gene Technology, KU Leuven, Leuven Belgium
Keywords: SARS-CoV-2, review, vaccine development, mice, hamsters, primates
Summary of Study: Do we need nasal vaccines against COVID 19
References: doi: 10.1111/1751-7915.14181
Contact Info: Harald Brüssow: [email protected]
URL: https://ami-journals.onlinelibrary.wiley.com/doi/full/10.1111/1751-7915.14181
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: The First Affiliated Hospital of Jinan University, Guangzhou 510630, China; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA USA
Keywords: SARS-CoV-2, favipiravir, biodistribution and pharmacokinetics, positron emission tomography, mice, primates
Summary of Study: Evaluating Favipiravir in rodents and nonhuman primates (NHP) with positron emission tomography
References: PMID: 37111280 / doi: 10.3390/ph16040524
Contact Info: Steven Liang: [email protected]
URL: https://www.mdpi.com/1424-8247/16/4/524
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: The First Affiliated Hospital of Jinan University, Guangzhou 510630, China; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA USA
Keywords: SARS-CoV-2, favipiravir, biodistribution and pharmacokinetics, positron emission tomography, mice, primates
Summary of Study: Evaluating Favipiravir in rodents and nonhuman primates (NHP) with positron emission tomography
References: PMID: 37111280 / doi: 10.3390/ph16040524
Contact Info: Steven Liang: [email protected]
URL: https://www.mdpi.com/1424-8247/16/4/524
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Faculty of Mathematics and Natural Sciences, University of Greifswald, Greifswald, Germany; Institute of Immunology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany; others
Keywords: SARS-CoV-2, review, tuberculosis, pathogenesis, several species, primates
Summary of Study: Animal models for COVID-19 and tuberculosis
References: DOI: 10.3389/fimmu.2023.1223260
Contact Info: Björn Corleis: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1223260/full
NHP Species: african green monkeys, rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: Faculty of Mathematics and Natural Sciences, University of Greifswald, Greifswald, Germany; Institute of Immunology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany; others
Keywords: SARS-CoV-2, review, tuberculosis, pathogenesis, several species, primates
Summary of Study: Animal models for COVID-19 and tuberculosis
References: DOI: 10.3389/fimmu.2023.1223260
Contact Info: Björn Corleis: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1223260/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, PA; others
Keywords: SARS-CoV-2, tetravalent S1 subunit protein vaccine, immune response, virus variants, primates
Summary of Study: Tetravalent S1 subunit protein vaccination elicits robust humoral and cellular immune responses
References: doi: 10.1101/2023.03.15.532808. Preprint
Contact Info: Christian Apetrei: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.03.15.532808v1
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, PA; others
Keywords: SARS-CoV-2, tetravalent S1 subunit protein vaccine, immune response, virus variants, primates
Summary of Study: Tetravalent S1 subunit protein vaccination elicits robust humoral and cellular immune responses
References: doi: 10.1101/2023.03.15.532808. Preprint
Contact Info: Christian Apetrei: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.03.15.532808v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Molecular Genetics, University of Toronto; Toronto, Canada; Icosagen Cell Factory OÜ; Tartu, Estonia; others
Keywords: SARS-CoV-2, humanized antibodies, immune response, vaccine, primates
Summary of Study: bnAb protection through inhalation-based delivery
References: DOI: 10.1371/journal.ppat.1011532
Contact Info: Mart Ustav, Jr.: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011532
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Department of Molecular Genetics, University of Toronto; Toronto, Canada; Icosagen Cell Factory OÜ; Tartu, Estonia; others
Keywords: SARS-CoV-2, humanized antibodies, immune response, vaccine, primates
Summary of Study: bnAb protection through inhalation-based delivery
References: DOI: 10.1371/journal.ppat.1011532
Contact Info: Mart Ustav, Jr.: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011532
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Microbiology, Shanghai Municipal Center for Disease Control and Prevention, Shanghai , China; Key Laboratory of Medical Molecular Virology, Shanghai Institute of Infectious Disease and Biosecurity, others.
Keywords: SARS-CoV-2, pan-sarbecovirus vaccine, immune response, virus protection, primates
Summary of Study: Pan-sarbecovirus vaccines against sarbecoviruses, including SARS-CoV-2 and its variants
References: doi: 10.1073/pnas.2221713120
Contact Info: LuLu: [email protected] (and other authors
URL: https://www.pnas.org/doi/10.1073/pnas.2221713120
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Microbiology, Shanghai Municipal Center for Disease Control and Prevention, Shanghai , China; Key Laboratory of Medical Molecular Virology, Shanghai Institute of Infectious Disease and Biosecurity, others.
Keywords: SARS-CoV-2, pan-sarbecovirus vaccine, immune response, virus protection, primates
Summary of Study: Pan-sarbecovirus vaccines against sarbecoviruses, including SARS-CoV-2 and its variants
References: doi: 10.1073/pnas.2221713120
Contact Info: LuLu: [email protected] (and other authors
URL: https://www.pnas.org/doi/10.1073/pnas.2221713120
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Federal Medical-Biological Agency of Russia, Moscow, Russia and others
Keywords: SARS-CoV-2, nucleocapsid (N) protein, vaccine, immune response, pathology, mice, hamsters, primates
Summary of Study: Recombinant nucleocapsid-based vaccine Convacell®.
References: PMID: 37112786 / doi: 10.3390/vaccines11040874
Contact Info: Sevastyan Rabdano: [email protected]
URL: https://www.mdpi.com/2076-393X/11/4/874
NHP Species: marmosets
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Federal Medical-Biological Agency of Russia, Moscow, Russia and others
Keywords: SARS-CoV-2, nucleocapsid (N) protein, vaccine, immune response, pathology, mice, hamsters, primates
Summary of Study: Recombinant nucleocapsid-based vaccine Convacell®.
References: PMID: 37112786 / doi: 10.3390/vaccines11040874
Contact Info: Sevastyan Rabdano: [email protected]
URL: https://www.mdpi.com/2076-393X/11/4/874
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Social and Administrative Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand; Center of Excellence in Plant-produced Pharmaceuticals, Chulalongkorn University, Bangkok, Thailand; others.
Keywords: SARS-CoV-2, plant-produced subunit vaccine, receptor binding domain, neutralizing antibody, primates
Summary of Study: Preclinical evaluation of immunogenicity, efficacy and safety of a recombinant plant-based vaccine
References: doi: 10.1016/j.vaccine.2023.03.027
Contact Info: Waranyoo Phoolcharoen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003122?via%3Dihub=
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Department of Social and Administrative Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand; Center of Excellence in Plant-produced Pharmaceuticals, Chulalongkorn University, Bangkok, Thailand; others.
Keywords: SARS-CoV-2, plant-produced subunit vaccine, receptor binding domain, neutralizing antibody, primates
Summary of Study: Preclinical evaluation of immunogenicity, efficacy and safety of a recombinant plant-based vaccine
References: doi: 10.1016/j.vaccine.2023.03.027
Contact Info: Waranyoo Phoolcharoen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003122?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD 20892, USA; others
Keywords: SARS-CoV-2, Adenoviral-vectored Vaccine Boosting, immune response, primates
Summary of Study: Mucosal adenoviral-vectored vaccine boosting prevents XBB.1.16 infection
References: bioRxiv. 2023 Nov 8:2023.11.06.565765. doi: 10.1101/2023.11.06.565765. Preprint. PMID: 37986823 PMCID: PMC10659340 DOI: 10.1101/2023.11.06.565765
Contact Info: Daniel Douek: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.11.06.565765v1
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD 20892, USA; others
Keywords: SARS-CoV-2, Adenoviral-vectored Vaccine Boosting, immune response, primates
Summary of Study: Mucosal adenoviral-vectored vaccine boosting prevents XBB.1.16 infection
References: bioRxiv. 2023 Nov 8:2023.11.06.565765. doi: 10.1101/2023.11.06.565765. Preprint. PMID: 37986823 PMCID: PMC10659340 DOI: 10.1101/2023.11.06.565765
Contact Info: Daniel Douek: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.11.06.565765v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Emory National Primate Research Center, Emory School of Medicine, others
Keywords: SARS-CoV-2, vaccine comparison, immune response, nasopharynx, primates
Summary of Study: Efficacy of mRNA-1273 and Novavax ancestral or BA.1 spike booster vaccines
References: doi: 10.1126/sciimmunol.adg7015
Contact Info: Rama Rao Amara: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.adg7015
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Emory National Primate Research Center, Emory School of Medicine, others
Keywords: SARS-CoV-2, vaccine comparison, immune response, nasopharynx, primates
Summary of Study: Efficacy of mRNA-1273 and Novavax ancestral or BA.1 spike booster vaccines
References: doi: 10.1126/sciimmunol.adg7015
Contact Info: Rama Rao Amara: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.adg7015
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: School of Pharmacy, University of Chinese Academy of Sciences, Beijing, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China, others
Keywords: SARS-CoV-2, nelfinavir, prophylactics, virus protection, humans, primates
Summary of Study: Nelfinavir preventive and therapeutic effects
References: PMID: 37095086 / doi: 10.1038/s41392-023-01429-0
Contact Info: Weiliang Zhu: [email protected]
URL: https://www.nature.com/articles/s41392-023-01429-0
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: School of Pharmacy, University of Chinese Academy of Sciences, Beijing, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China, others
Keywords: SARS-CoV-2, nelfinavir, prophylactics, virus protection, humans, primates
Summary of Study: Nelfinavir preventive and therapeutic effects
References: PMID: 37095086 / doi: 10.1038/s41392-023-01429-0
Contact Info: Weiliang Zhu: [email protected]
URL: https://www.nature.com/articles/s41392-023-01429-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2023
Study Type/Review: pathogenesis, review
NPRC/Institute: Primate Resources Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup-si, Jeonbuk, Korea; Korea National University of Science and Technology (UST), Daejeon, Korea.
Keywords: SARS-CoV-2, animal models, species sensitivity, other viruses, primates
Summary of Study: NHPs to combat COVID-19 and viral infectious disease outbreaks
References: PMID: 38084001 DOI: 10.1111/jmp.12689
Contact Info: Taeho Kwan: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1111/jmp.12689
NHP Species: multiple species
Year Published: 2023
Study Type/Review: pathogenesis, review
NPRC/Institute: Primate Resources Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup-si, Jeonbuk, Korea; Korea National University of Science and Technology (UST), Daejeon, Korea.
Keywords: SARS-CoV-2, animal models, species sensitivity, other viruses, primates
Summary of Study: NHPs to combat COVID-19 and viral infectious disease outbreaks
References: PMID: 38084001 DOI: 10.1111/jmp.12689
Contact Info: Taeho Kwan: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1111/jmp.12689
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China; others
Keywords: SARS-CoV-2, pathogenesis, immune response, mice, hamsters, primates
Summary of Study: SARS-CoV-2 Omicron (B.1.1.529) infection in rhesus macaques, hamsters, and BALB/c mice with severe lung histopathological damage.
References: DOI: 10.1002/jmv.28846
Contact Info: Shuaiyao Lu: [email protected]
URL: https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.28846
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China; others
Keywords: SARS-CoV-2, pathogenesis, immune response, mice, hamsters, primates
Summary of Study: SARS-CoV-2 Omicron (B.1.1.529) infection in rhesus macaques, hamsters, and BALB/c mice with severe lung histopathological damage.
References: DOI: 10.1002/jmv.28846
Contact Info: Shuaiyao Lu: [email protected]
URL: https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.28846
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, China and others
Keywords: SARS-CoV-2, intradermal inactivated vaccine, immune response, virus variants, primates
Summary of Study: Preclinical safety evaluation of Intradermal inactivated vaccine (vero cells) administration
References: PMID: 37003910 / doi: 10.1016/j.vaccine.2023.03.033
Contact Info: Qihan Li: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003171?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, China and others
Keywords: SARS-CoV-2, intradermal inactivated vaccine, immune response, virus variants, primates
Summary of Study: Preclinical safety evaluation of Intradermal inactivated vaccine (vero cells) administration
References: PMID: 37003910 / doi: 10.1016/j.vaccine.2023.03.033
Contact Info: Qihan Li: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X23003171?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: University of Bremen, Bremen, Germany and others
Keywords: SARS-CoV-2, mRNA vaccination, elderly animals, immune response, primates
Summary of Study: Monitoring vaccination in laboratory rhesus monkeys
References: doi: 10.1038/s41598-023-30473-7
Contact Info: Detlef Wegener: [email protected]
URL: https://www.nature.com/articles/s41598-023-30473-7
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: University of Bremen, Bremen, Germany and others
Keywords: SARS-CoV-2, mRNA vaccination, elderly animals, immune response, primates
Summary of Study: Monitoring vaccination in laboratory rhesus monkeys
References: doi: 10.1038/s41598-023-30473-7
Contact Info: Detlef Wegener: [email protected]
URL: https://www.nature.com/articles/s41598-023-30473-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Sanofi, Vaccines R&D, Marcy l'Etoile, France, and others
Keywords: SARS-CoV-2, bivalent vaccine, virus variants, immune response, primates
Summary of Study: Beta-containing bivalent SARS-CoV-2 protein vaccine elicits durable broad neutralization
References: doi: 10.1038/s43856-023-00302-z
Contact Info: Valerie Lecouturier: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212738/
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Sanofi, Vaccines R&D, Marcy l'Etoile, France, and others
Keywords: SARS-CoV-2, bivalent vaccine, virus variants, immune response, primates
Summary of Study: Beta-containing bivalent SARS-CoV-2 protein vaccine elicits durable broad neutralization
References: doi: 10.1038/s43856-023-00302-z
Contact Info: Valerie Lecouturier: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212738/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Shulan International Medical College, Zhejiang Shuren University, Hangzhou, 310000, China, others
Keywords: SARS-CoV-2, inactivated vaccine, immune response, primates
Summary of Study: Delta (B.1.617.2) inactivated vaccine candidate elicits neutralizing antibodies
References: doi: 10.1016/j.virs.2023.05.009
Contact Info: Keda Chen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1995820X23000573?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Shulan International Medical College, Zhejiang Shuren University, Hangzhou, 310000, China, others
Keywords: SARS-CoV-2, inactivated vaccine, immune response, primates
Summary of Study: Delta (B.1.617.2) inactivated vaccine candidate elicits neutralizing antibodies
References: doi: 10.1016/j.virs.2023.05.009
Contact Info: Keda Chen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1995820X23000573?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Janssen Research and Development, Beerse, Belgium and Janssen Vaccines and Prevention B.V., Leiden, The Netherlands
Keywords: SARS-CoV-2, mechanistic modeling, vaccination, immune response, primates
Summary of Study: Humoral Immunity Following Ad26.COV2.S Vaccination
References: DOI: 10.1124/jpet.123.001591
Contact Info: Anna Dari: [email protected]
URL: https://jpet.aspetjournals.org/content/387/1/121.long
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Janssen Research and Development, Beerse, Belgium and Janssen Vaccines and Prevention B.V., Leiden, The Netherlands
Keywords: SARS-CoV-2, mechanistic modeling, vaccination, immune response, primates
Summary of Study: Humoral Immunity Following Ad26.COV2.S Vaccination
References: DOI: 10.1124/jpet.123.001591
Contact Info: Anna Dari: [email protected]
URL: https://jpet.aspetjournals.org/content/387/1/121.long
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Institut Pasteur, Université Paris Cité, National Reference Center for Respiratory Viruses, Paris, France; others
Keywords: SARS-CoV-2, monoclonal antibody treatment, immune response, primates
Summary of Study: Sotrovimab retains activity against SARS-CoV-2 omicron variant BQ.1.1 in a non-human primate model.
References: DOI: 10.1016/j.heliyon.2023.e16664
Contact Info: Roger Le Grand: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2405844023038719?via%3Dihub=
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Institut Pasteur, Université Paris Cité, National Reference Center for Respiratory Viruses, Paris, France; others
Keywords: SARS-CoV-2, monoclonal antibody treatment, immune response, primates
Summary of Study: Sotrovimab retains activity against SARS-CoV-2 omicron variant BQ.1.1 in a non-human primate model.
References: DOI: 10.1016/j.heliyon.2023.e16664
Contact Info: Roger Le Grand: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2405844023038719?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: University of Kentucky, Oregon National Primate Research Center, University of California, Irvine
Keywords: SARS-CoV-2, alcohol, lung, scRNA-seq, inflammation, primates
Summary of Study: Alcohol consumption dysregulates immune response in lungs
References: doi: 10.1101/2023.05.02.539139. Preprint
Contact Info: Ilhelm Messaoudi: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187161/
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: University of Kentucky, Oregon National Primate Research Center, University of California, Irvine
Keywords: SARS-CoV-2, alcohol, lung, scRNA-seq, inflammation, primates
Summary of Study: Alcohol consumption dysregulates immune response in lungs
References: doi: 10.1101/2023.05.02.539139. Preprint
Contact Info: Ilhelm Messaoudi: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187161/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China; others
Keywords: SARS-CoV-2, pathogenesis, immune response, mice, hamsters, primates
Summary of Study: SARS-CoV-2 Omicron (B.1.1.529) infection in rhesus macaques, hamsters, and BALB/c mice with severe lung histopathological damage.
References: DOI: 10.1002/jmv.28846
Contact Info: Shuaiyao Lu: [email protected]
URL: https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.28846
NHP Species: rhesus macaques
Year Published: 2023
Study Type/Review:
NPRC/Institute: State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China; others
Keywords: SARS-CoV-2, pathogenesis, immune response, mice, hamsters, primates
Summary of Study: SARS-CoV-2 Omicron (B.1.1.529) infection in rhesus macaques, hamsters, and BALB/c mice with severe lung histopathological damage.
References: DOI: 10.1002/jmv.28846
Contact Info: Shuaiyao Lu: [email protected]
URL: https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.28846
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland; Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Mary
Keywords: SARS-CoV-2, deep learning, computerized tomography, lung lesions, primates
Summary of Study: Modeling whole lung and lung lesions to detect and quantify disease
References: doi: 10.1016/j.acra.2023.02.027
Contact Info: [email protected]
URL: https://pubmed.ncbi.nlm.nih.gov/36966070/
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland; Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Mary
Keywords: SARS-CoV-2, deep learning, computerized tomography, lung lesions, primates
Summary of Study: Modeling whole lung and lung lesions to detect and quantify disease
References: doi: 10.1016/j.acra.2023.02.027
Contact Info: [email protected]
URL: https://pubmed.ncbi.nlm.nih.gov/36966070/
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School, Boston, MA, USA; Beth Israel Deaconess Medical Center, Boston, MA, USA, others
Keywords: SARS-CoV-2, immunogenicity and protective efficacy, Ad26.COV2.S vaccine, primates
Summary of Study: Spike protein ferritin nanoparticle vaccine
References: PMID: 37023746 / doi: 10.1016/j.xcrm.2023.101018
Contact Info: Dan Barouch: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379123001283?via%3Dihub=
NHP Species:
Year Published: 2023
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School, Boston, MA, USA; Beth Israel Deaconess Medical Center, Boston, MA, USA, others
Keywords: SARS-CoV-2, immunogenicity and protective efficacy, Ad26.COV2.S vaccine, primates
Summary of Study: Spike protein ferritin nanoparticle vaccine
References: PMID: 37023746 / doi: 10.1016/j.xcrm.2023.101018
Contact Info: Dan Barouch: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379123001283?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Vaccine Research Institute, Créteil, France; Université Paris Cité, IAME, Inserm, Paris, France; others
Keywords: SARS-CoV-2, mathematical model, viral dynamic, primates
Summary of Study: Impact of variants of concern on SARS-CoV-2 viral dynamics
References: DOI: 10.1371/journal.pcbi.1010721
Contact Info: Aurélien Marc: [email protected]
URL: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1010721
NHP Species:
Year Published: 2023
Study Type/Review:
NPRC/Institute: Vaccine Research Institute, Créteil, France; Université Paris Cité, IAME, Inserm, Paris, France; others
Keywords: SARS-CoV-2, mathematical model, viral dynamic, primates
Summary of Study: Impact of variants of concern on SARS-CoV-2 viral dynamics
References: DOI: 10.1371/journal.pcbi.1010721
Contact Info: Aurélien Marc: [email protected]
URL: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1010721
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Washington University; National Cancer Institute/NIH; Bioqual; Oak Ridge Institute of Science & Education; Columbia University Vagelos College of Physicians and Surgeons; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, spike protein ferritin nanoparticle (SpFN) vaccine, immune response, primates
Summary of Study: NHPs vaccinated with two doses of SpFN plus adjuvant separated by 28 days developed potent SARS-CoV-2-specific B and T cell responses, which conferred protection against SARS-CoV-2 challenge.
References: PMID: 34914540 / doi: 10.1126/scitranslmed.abi5735
Contact Info: Kayvon Modjarrad: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abi5735?url_ver=Z39.88-2003&rf…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Washington University; National Cancer Institute/NIH; Bioqual; Oak Ridge Institute of Science & Education; Columbia University Vagelos College of Physicians and Surgeons; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, spike protein ferritin nanoparticle (SpFN) vaccine, immune response, primates
Summary of Study: NHPs vaccinated with two doses of SpFN plus adjuvant separated by 28 days developed potent SARS-CoV-2-specific B and T cell responses, which conferred protection against SARS-CoV-2 challenge.
References: PMID: 34914540 / doi: 10.1126/scitranslmed.abi5735
Contact Info: Kayvon Modjarrad: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abi5735?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center, Texas Biomedical Research Institute; Washington University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, longitudinal scRNAseq, bronchoalveolar lavage, immune response, primates
Summary of Study: Results unequivocally show that in protected, immunocompetent hosts, SARS-CoV-2 infection is characterized by an acute inflammatory response leading to a myeloid cell influx into the lung compartment. Induction of a robust IFN response in macrophages strongly correlates with viremia and subsequent clearance of SARS-CoV-2 from the airways of macaques.
References: PMID: 35115549 / doi: 10.1038/s41467-022-28315-7
Contact Info: Maxim Artyomov: [email protected]
URL: https://www.nature.com/articles/s41467-022-28315-7
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center, Texas Biomedical Research Institute; Washington University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, longitudinal scRNAseq, bronchoalveolar lavage, immune response, primates
Summary of Study: Results unequivocally show that in protected, immunocompetent hosts, SARS-CoV-2 infection is characterized by an acute inflammatory response leading to a myeloid cell influx into the lung compartment. Induction of a robust IFN response in macrophages strongly correlates with viremia and subsequent clearance of SARS-CoV-2 from the airways of macaques.
References: PMID: 35115549 / doi: 10.1038/s41467-022-28315-7
Contact Info: Maxim Artyomov: [email protected]
URL: https://www.nature.com/articles/s41467-022-28315-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: MIT; Broad Institute of MIT and Harvard; Ragan Institute of MGH, MIT, and Harvard; University of Duisburg-Essen; Space Exploration Technologies Corp.; Harvard University; Vanderbilt University Medical Center; Northwestern University Feinberg School of Medicine; University of Bonn; Howard Hughes Medical Institute; Massachusetts Consortium on Pathogen Readiness; Harvard Medical School; Brigham and Womoen's Hospital; Harvard Humanitarian Initiative
Keywords: SARS-CoV-2, immune biomarkers, reinfection, immune response, primates
Summary of Study: A specific set of SARS-CoV-2-specific humoral features, including spike RBD-specific IgG1 titers, nucleocapsid-specific IgG3 titers, and anti-spike RBD FcyR2A binding activity, were identified as robust biomarkers of reinfection that translate across species. When reinfection cannot be confirmed by viral sequence, changes in SARS-CoV-2 humoral immune responses may offer inexpensive, reliable, and effective measures to track reinfection.
References: PMID: 35073738 / doi: 10.1128/mbio.02141-21
Contact Info: Douglas Lauffenburger: [email protected]; Galit Alter: [email protected]
URL: https://journals.asm.org/doi/full/10.1128/mbio.02141-21?rfr_dat=cr_pub%20%200pu…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: MIT; Broad Institute of MIT and Harvard; Ragan Institute of MGH, MIT, and Harvard; University of Duisburg-Essen; Space Exploration Technologies Corp.; Harvard University; Vanderbilt University Medical Center; Northwestern University Feinberg School of Medicine; University of Bonn; Howard Hughes Medical Institute; Massachusetts Consortium on Pathogen Readiness; Harvard Medical School; Brigham and Womoen's Hospital; Harvard Humanitarian Initiative
Keywords: SARS-CoV-2, immune biomarkers, reinfection, immune response, primates
Summary of Study: A specific set of SARS-CoV-2-specific humoral features, including spike RBD-specific IgG1 titers, nucleocapsid-specific IgG3 titers, and anti-spike RBD FcyR2A binding activity, were identified as robust biomarkers of reinfection that translate across species. When reinfection cannot be confirmed by viral sequence, changes in SARS-CoV-2 humoral immune responses may offer inexpensive, reliable, and effective measures to track reinfection.
References: PMID: 35073738 / doi: 10.1128/mbio.02141-21
Contact Info: Douglas Lauffenburger: [email protected]; Galit Alter: [email protected]
URL: https://journals.asm.org/doi/full/10.1128/mbio.02141-21?rfr_dat=cr_pub%20%200pu…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medicine Sciences & Peking Union Medical College; National Institute for Viral Disease Control and Prevention
Keywords: SARS-CoV-2, heterologous vaccines, intradermal administration, immune response, primates
Summary of Study: This study reports a new heterologous prime-boost strategy of intradermal immunization with the inactivated vaccine and K-S antigen. This strategy can significantly increase the neutralizing antibody titers and promote specific T cell responses in mice and macaques.
References: PMID: 34931939 / doi: 10.1080/22221751.2021807https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
Contact Info: Wenbo Xu: [email protected]; Qihan Li: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medicine Sciences & Peking Union Medical College; National Institute for Viral Disease Control and Prevention
Keywords: SARS-CoV-2, heterologous vaccines, intradermal administration, immune response, primates
Summary of Study: This study reports a new heterologous prime-boost strategy of intradermal immunization with the inactivated vaccine and K-S antigen. This strategy can significantly increase the neutralizing antibody titers and promote specific T cell responses in mice and macaques.
References: PMID: 34931939 / doi: 10.1080/22221751.2021807https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
Contact Info: Wenbo Xu: [email protected]; Qihan Li: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2021807
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Medicago Inc.; Stanford University School of Medicine; Tulane National Primate Research Center; Tulane University School of Medicine; Research Institute of the McGill University Health Centre
Keywords: SARS-CoV-2, unadjuvanted and adjuvanted formulations, recombinant plant-derived virus-like particle vaccine, safety, immune response, primates
Summary of Study: A VLP bearing a SARS-CoV-2 spike protein vaccine candidate formulated with Adjuvant System 03 (AS03) was shown to be safe and effective and was therefore selected for vaccine development and clinical trials.
References: PMID: 34983950 / doi: 10.1038/s41423-021-00809-2
Contact Info: Brian Ward: [email protected]
URL: https://www.nature.com/articles/s41423-021-00809-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Medicago Inc.; Stanford University School of Medicine; Tulane National Primate Research Center; Tulane University School of Medicine; Research Institute of the McGill University Health Centre
Keywords: SARS-CoV-2, unadjuvanted and adjuvanted formulations, recombinant plant-derived virus-like particle vaccine, safety, immune response, primates
Summary of Study: A VLP bearing a SARS-CoV-2 spike protein vaccine candidate formulated with Adjuvant System 03 (AS03) was shown to be safe and effective and was therefore selected for vaccine development and clinical trials.
References: PMID: 34983950 / doi: 10.1038/s41423-021-00809-2
Contact Info: Brian Ward: [email protected]
URL: https://www.nature.com/articles/s41423-021-00809-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: City of Hope National Medical Center
Keywords: SARS-CoV-2, synthetic multiantigen modified vaccine, COH04S1, immune response, hamsters, primates
Summary of Study: Vaccine candidate C0H04S1 stimulates protective immunity against SARS-CoV-2 in Syrian hamsters by intramuscular and intranasal vaccination and in non-human primates through two-dose and single-dose regimens.
References: PMID: 35064109 / doi: 10.1038/s41541-022-00436-6
Contact Info: Felix Wussow: [email protected]
URL: https://www.nature.com/articles/s41541-022-00436-6
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: City of Hope National Medical Center
Keywords: SARS-CoV-2, synthetic multiantigen modified vaccine, COH04S1, immune response, hamsters, primates
Summary of Study: Vaccine candidate C0H04S1 stimulates protective immunity against SARS-CoV-2 in Syrian hamsters by intramuscular and intranasal vaccination and in non-human primates through two-dose and single-dose regimens.
References: PMID: 35064109 / doi: 10.1038/s41541-022-00436-6
Contact Info: Felix Wussow: [email protected]
URL: https://www.nature.com/articles/s41541-022-00436-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shanghai Medical College, Fudan University; Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College; the First Affiliated Hospital of Guangzhou Medical University; Guangzhou Eighth People's Hospital of Guangzhou Medical University; Bio-Island; Graduate School of Peking Union Medical College; NIFDC; Fulgent Pharma LLC
Keywords: SARS-CoV-2, pan-sarbecovirus vaccines, STING agonist CF501, virus variants, immune response, mice, rabbits, primates.
Summary of Study: A pan-sarbecovirus vaccine was designed by using human IgG Fc-conjugated RBD from the original SARS-CoV-2 strain as the vaccine's immunogen and the STING agonist CF501 as the vaccine's adjuvant. This CF501/RBD-Fc vaccine candidate was able to induce extremely potent, durable, and broad-spectrum nAb and T cell responses, as well as protective immunity, suggesting its potential for development as a highly potent and durable pan-sarbecovirus vaccine.
References: PMID: 35046518 / doi: 10.1038/s41422-022-00612-2
Contact Info: Youchun Wang: [email protected]; Yilong Zhang: [email protected]; Jincun Zhao: [email protected]
URL: https://www.nature.com/articles/s41422-022-00612-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shanghai Medical College, Fudan University; Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College; the First Affiliated Hospital of Guangzhou Medical University; Guangzhou Eighth People's Hospital of Guangzhou Medical University; Bio-Island; Graduate School of Peking Union Medical College; NIFDC; Fulgent Pharma LLC
Keywords: SARS-CoV-2, pan-sarbecovirus vaccines, STING agonist CF501, virus variants, immune response, mice, rabbits, primates.
Summary of Study: A pan-sarbecovirus vaccine was designed by using human IgG Fc-conjugated RBD from the original SARS-CoV-2 strain as the vaccine's immunogen and the STING agonist CF501 as the vaccine's adjuvant. This CF501/RBD-Fc vaccine candidate was able to induce extremely potent, durable, and broad-spectrum nAb and T cell responses, as well as protective immunity, suggesting its potential for development as a highly potent and durable pan-sarbecovirus vaccine.
References: PMID: 35046518 / doi: 10.1038/s41422-022-00612-2
Contact Info: Youchun Wang: [email protected]; Yilong Zhang: [email protected]; Jincun Zhao: [email protected]
URL: https://www.nature.com/articles/s41422-022-00612-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Zhongshan School of Medicine; Qianyang Biomedical Research Institute; Guangdong Provincial Center for Disease Control and Prevention
Keywords: SARS-CoV-2, bivalent vaccine, D614G/B.1.351, vaccine dosage, mice, primates
Summary of Study: With a prime-boost or single-dose strategy a bivalent D614G/B.1.351 RBD nanoparticle vaccine elicited robust nAbs and full protection against infection with the authentic D614 or B.1.351 strains in human ACE2 transgene mice. Furthermore, 8 months after inoculation with the D614G-specific vaccine, a new boost with this bivalent vaccine potently elicited cross-nAbs for SARS-CoV-2 variants in rhesus macaques.
References: PMID: 34990583 / doi: 10.1016/j.celrep.2021.110256
Contact Info: Yiwen Zhang: [email protected]; Hui Zhang: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S221112472101768X?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Zhongshan School of Medicine; Qianyang Biomedical Research Institute; Guangdong Provincial Center for Disease Control and Prevention
Keywords: SARS-CoV-2, bivalent vaccine, D614G/B.1.351, vaccine dosage, mice, primates
Summary of Study: With a prime-boost or single-dose strategy a bivalent D614G/B.1.351 RBD nanoparticle vaccine elicited robust nAbs and full protection against infection with the authentic D614 or B.1.351 strains in human ACE2 transgene mice. Furthermore, 8 months after inoculation with the D614G-specific vaccine, a new boost with this bivalent vaccine potently elicited cross-nAbs for SARS-CoV-2 variants in rhesus macaques.
References: PMID: 34990583 / doi: 10.1016/j.celrep.2021.110256
Contact Info: Yiwen Zhang: [email protected]; Hui Zhang: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S221112472101768X?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre/The Netherlands; NIAID; University Paris-Saclay, Inserm; Tulane National Primate Research Center; University of Pittsburgh School of Medicine; University of Pittsburgh Center for Vaccine Research; Texas Biomedical Research Institute; Frederick National Laboratory for Cancer Research
Keywords: SARS-CoV-2, advanced medical imaging, pathogenesis, primates
Summary of Study: The reviewers argue that advanced imaging tools add unique insight into poorly understood relationships of SARS-CV-2 exposure, infection, the host response, and disease presentation in the lungs.
References: PMID: 34955425 / doi: 10.1016/j.molmed.2021.12.001
Contact Info: Marieke Stammes: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1471491421003166?via%3Dihub=
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre/The Netherlands; NIAID; University Paris-Saclay, Inserm; Tulane National Primate Research Center; University of Pittsburgh School of Medicine; University of Pittsburgh Center for Vaccine Research; Texas Biomedical Research Institute; Frederick National Laboratory for Cancer Research
Keywords: SARS-CoV-2, advanced medical imaging, pathogenesis, primates
Summary of Study: The reviewers argue that advanced imaging tools add unique insight into poorly understood relationships of SARS-CV-2 exposure, infection, the host response, and disease presentation in the lungs.
References: PMID: 34955425 / doi: 10.1016/j.molmed.2021.12.001
Contact Info: Marieke Stammes: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1471491421003166?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; University of Oxford
Keywords: SARS-CoV-2, age-specific immune responses, viral load, primates
Summary of Study: Despite similar disease outcomes, multiomics profiling suggests that age may delay or impair antiviral cellular immune responses and delay efficient return to homeostasis.
References: PMID: 35039442 / doi: 10.26508/lsa.202101314
Contact Info: Emmie de Wit: [email protected]
URL: https://www.life-science-alliance.org/content/5/4/e202101314
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; University of Oxford
Keywords: SARS-CoV-2, age-specific immune responses, viral load, primates
Summary of Study: Despite similar disease outcomes, multiomics profiling suggests that age may delay or impair antiviral cellular immune responses and delay efficient return to homeostasis.
References: PMID: 35039442 / doi: 10.26508/lsa.202101314
Contact Info: Emmie de Wit: [email protected]
URL: https://www.life-science-alliance.org/content/5/4/e202101314
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: prevention
NPRC/Institute: AstraZeneca; BIOQUAL; Vanderbilt University; USAMRIID
Keywords: SARS-CoV-2, monoclonal antibody combination, AZD7442,virus protection, humans, primates
Summary of Study: AZD7442, a monoclonal antibody comprised of AZD8895 and AZD1061, demonstrated potent in vitro neutralization against SARS-CoV-2 VOCs, in vivo efficacy in both prevention and treatment settings of SARS-CoV-2 infection in NHPs, and extended half-life in NHPs and healthy adult participants.
References: PMID: 35076282 / doi: 10.1126/scitranslmed.abl8124
Contact Info: Mark Esser: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abl8124?url_ver=Z39.88-2003&rf…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: prevention
NPRC/Institute: AstraZeneca; BIOQUAL; Vanderbilt University; USAMRIID
Keywords: SARS-CoV-2, monoclonal antibody combination, AZD7442,virus protection, humans, primates
Summary of Study: AZD7442, a monoclonal antibody comprised of AZD8895 and AZD1061, demonstrated potent in vitro neutralization against SARS-CoV-2 VOCs, in vivo efficacy in both prevention and treatment settings of SARS-CoV-2 infection in NHPs, and extended half-life in NHPs and healthy adult participants.
References: PMID: 35076282 / doi: 10.1126/scitranslmed.abl8124
Contact Info: Mark Esser: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abl8124?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine; Nanchang University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, CRISPR-RT–PCR assay, longitudinal analysis, mucosal, plasma, and breath samples, primates
Summary of Study: CRISPR-FDS may provide a means to evaluate systemic viral/viral RNA burden not detectable by RT-qPCR to improve diagnosis and better predict outcomes for SARS-CoV-2 infections.
References: PMID: 35108153 / doi: 10.1080/22221751.2038020
Contact Info: Tony Hu: tonyhu2tulane.edu
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2038020
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine; Nanchang University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, CRISPR-RT–PCR assay, longitudinal analysis, mucosal, plasma, and breath samples, primates
Summary of Study: CRISPR-FDS may provide a means to evaluate systemic viral/viral RNA burden not detectable by RT-qPCR to improve diagnosis and better predict outcomes for SARS-CoV-2 infections.
References: PMID: 35108153 / doi: 10.1080/22221751.2038020
Contact Info: Tony Hu: tonyhu2tulane.edu
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2038020
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences; Fudan University; Shanghai King-Cell Biotechnology Co., Ltd.; Mabwell Bioscience Co., Ltd.; Shenzhen University; University of Chinese Academy of Sciences
Keywords: SARS-CoV-2, self-adjuvanting peptide vaccine, CoVac501, immune response, virus variants, primates
Summary of Study: CoVac501, a novel SARS-CoV-2 vaccine that is fully chemically synthesized and self-adjuvanting, provided potent protection for cynomolgus macaques against challenges from very high doses of SARS-CoV-2.
References: PMID: 35102138 / doi: 10.1038/s41421-021-00370-2
Contact Info: Qiuping Qin: [email protected]
URL: https://www.nature.com/articles/s41421-021-00370-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences; Fudan University; Shanghai King-Cell Biotechnology Co., Ltd.; Mabwell Bioscience Co., Ltd.; Shenzhen University; University of Chinese Academy of Sciences
Keywords: SARS-CoV-2, self-adjuvanting peptide vaccine, CoVac501, immune response, virus variants, primates
Summary of Study: CoVac501, a novel SARS-CoV-2 vaccine that is fully chemically synthesized and self-adjuvanting, provided potent protection for cynomolgus macaques against challenges from very high doses of SARS-CoV-2.
References: PMID: 35102138 / doi: 10.1038/s41421-021-00370-2
Contact Info: Qiuping Qin: [email protected]
URL: https://www.nature.com/articles/s41421-021-00370-2
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Emergent BioSolutions; Yoh Services LLC; Sanofi Pasteur; Translate Bio; UT Health Science Center at Houston
Keywords: SARS-CoV-2, virus variants, vaccine, boost, neutralizing effects, primates
Summary of Study: This study showed that a third vaccination administered as a booster, regardless of composition, to the currently approved two dose regimens could effectively promote broadly neutralizing antibodies against all variants of concern.
References: PMID: 35101265 / doi: 10.1016/j.vaccine.2022.01.021
Contact Info: Natalie Anosova: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22000457?via%3Dihub=
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Emergent BioSolutions; Yoh Services LLC; Sanofi Pasteur; Translate Bio; UT Health Science Center at Houston
Keywords: SARS-CoV-2, virus variants, vaccine, boost, neutralizing effects, primates
Summary of Study: This study showed that a third vaccination administered as a booster, regardless of composition, to the currently approved two dose regimens could effectively promote broadly neutralizing antibodies against all variants of concern.
References: PMID: 35101265 / doi: 10.1016/j.vaccine.2022.01.021
Contact Info: Natalie Anosova: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22000457?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, proteomic and phosphoproteomic profiling, lung and liver pathology, primates
Summary of Study: Proteomic and phosphoproteomic profiling of SARS-CoV-2-infected lung and liver tissues showed potentially active protein synthesis and processing, and dysregulated ECM, cell-to-cell junction, and cytoskeleton but no fibrosis in both the infected lung and liver.
References: PMID: 35091530 / doi: 10.1038/s41392-022-00882-7
Contact Info: Shaui-Yao Lu: [email protected]
URL: https://www.nature.com/articles/s41392-022-00882-7
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, proteomic and phosphoproteomic profiling, lung and liver pathology, primates
Summary of Study: Proteomic and phosphoproteomic profiling of SARS-CoV-2-infected lung and liver tissues showed potentially active protein synthesis and processing, and dysregulated ECM, cell-to-cell junction, and cytoskeleton but no fibrosis in both the infected lung and liver.
References: PMID: 35091530 / doi: 10.1038/s41392-022-00882-7
Contact Info: Shaui-Yao Lu: [email protected]
URL: https://www.nature.com/articles/s41392-022-00882-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; Gilead Sciences
Keywords: SARS-CoV-2, Remdesivir, subcutaneous administration, pathology, virus load, primates
Summary of Study: Early subcutaneous administration of remdesivir can protect from lower respiratory tract disease caused by SARS-CoV-2.
References: PMID: 35032523 / doi: 10.1016/j.antiviral.2022.105246
Contact Info: Emmie de Wit: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0166354222000146?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; Gilead Sciences
Keywords: SARS-CoV-2, Remdesivir, subcutaneous administration, pathology, virus load, primates
Summary of Study: Early subcutaneous administration of remdesivir can protect from lower respiratory tract disease caused by SARS-CoV-2.
References: PMID: 35032523 / doi: 10.1016/j.antiviral.2022.105246
Contact Info: Emmie de Wit: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0166354222000146?via%3Dihub=