Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Institutes for Food and Drug Control, Beijing; Guangzhou Laboratory; Kunming National High-level Biosafety Primate Research Center
Keywords: SARS-CoV-2, vaccine, chimpanzee adenovirus vector, immune response, mice, primates
Summary of Study: Using a chimpanzee adenovirus vectored vaccine expressing SARS-CoV2 spike in combination with an inactivated vaccine reduced lung injury risk while maintaining flexibility of the antibody regulation system.
References: PMID: 36059554 / doi: 10.3389/fimmu.2022.949248
Contact Info: Junzhi Wang: [email protected]; Zhenglun Liang: [email protected]; Miao Xu: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.949248/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Institutes for Food and Drug Control, Beijing; Guangzhou Laboratory; Kunming National High-level Biosafety Primate Research Center
Keywords: SARS-CoV-2, vaccine, chimpanzee adenovirus vector, immune response, mice, primates
Summary of Study: Using a chimpanzee adenovirus vectored vaccine expressing SARS-CoV2 spike in combination with an inactivated vaccine reduced lung injury risk while maintaining flexibility of the antibody regulation system.
References: PMID: 36059554 / doi: 10.3389/fimmu.2022.949248
Contact Info: Junzhi Wang: [email protected]; Zhenglun Liang: [email protected]; Miao Xu: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.949248/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: North Carolina State University; University of North Carolina at Chapel Hill
Keywords: SARS-CoV-2, dry powder mRNA vaccine, tissue distribution, mice, primates
Summary of Study: Room-temperature stable inhalable lung-derived exosomes have been developed as mRNA and protein drug carriers, and they are deliverable to the lungs by dry powder inhalation and result in a greater immunoglobulin responsecompared to the standard.
References: PMID: 35847197 / doi: 10.1016/j.matt.2022.06.012
Contact Info: Ke Cheng: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272513/
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: North Carolina State University; University of North Carolina at Chapel Hill
Keywords: SARS-CoV-2, dry powder mRNA vaccine, tissue distribution, mice, primates
Summary of Study: Room-temperature stable inhalable lung-derived exosomes have been developed as mRNA and protein drug carriers, and they are deliverable to the lungs by dry powder inhalation and result in a greater immunoglobulin responsecompared to the standard.
References: PMID: 35847197 / doi: 10.1016/j.matt.2022.06.012
Contact Info: Ke Cheng: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272513/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: California National Primate Research Center; University of California, Davis
Keywords: SARS-CoV-2, neurotropism, microglia, astrocytes, inflammation, aging, primates
Summary of Study: SARS-CoV-2 infects neurons and induces neuroinflammation
References: doi: 10.1016/j.celrep.2022.111573
Contact Info: John H. Morrison: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554328/#:~:text=Seven%20days%20af…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: pathogenesis
NPRC/Institute: California National Primate Research Center; University of California, Davis
Keywords: SARS-CoV-2, neurotropism, microglia, astrocytes, inflammation, aging, primates
Summary of Study: SARS-CoV-2 infects neurons and induces neuroinflammation
References: doi: 10.1016/j.celrep.2022.111573
Contact Info: John H. Morrison: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554328/#:~:text=Seven%20days%20af…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Oxford, UK; Ifakara Health Institute, Bagamoyo, Tanzania
Keywords: SARS-CoV-2, review, long-lived plasma cells, lymph node germinal centers, humans, primates
Summary of Study: Human lymphoid tissue sampling for vaccinology
References: doi: 10.3389/fimmu.2022.1045529
Contact Info: Carolyn M. Nielsen: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1045529/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Oxford, UK; Ifakara Health Institute, Bagamoyo, Tanzania
Keywords: SARS-CoV-2, review, long-lived plasma cells, lymph node germinal centers, humans, primates
Summary of Study: Human lymphoid tissue sampling for vaccinology
References: doi: 10.3389/fimmu.2022.1045529
Contact Info: Carolyn M. Nielsen: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1045529/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: City of Hope National Medical Center
Keywords: SARS-CoV-2, synthetic multiantigen modified vaccine, COH04S1, immune response, hamsters, primates
Summary of Study: Vaccine candidate C0H04S1 stimulates protective immunity against SARS-CoV-2 in Syrian hamsters by intramuscular and intranasal vaccination and in non-human primates through two-dose and single-dose regimens.
References: PMID: 35064109 / doi: 10.1038/s41541-022-00436-6
Contact Info: Felix Wussow: [email protected]
URL: https://www.nature.com/articles/s41541-022-00436-6
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: City of Hope National Medical Center
Keywords: SARS-CoV-2, synthetic multiantigen modified vaccine, COH04S1, immune response, hamsters, primates
Summary of Study: Vaccine candidate C0H04S1 stimulates protective immunity against SARS-CoV-2 in Syrian hamsters by intramuscular and intranasal vaccination and in non-human primates through two-dose and single-dose regimens.
References: PMID: 35064109 / doi: 10.1038/s41541-022-00436-6
Contact Info: Felix Wussow: [email protected]
URL: https://www.nature.com/articles/s41541-022-00436-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences & Peking Union Medical College; National Institute for Viral Disease Control and Prevention
Keywords: SARS-CoV-2, inactivated vaccine, pathology, virus variants, primates
Summary of Study: Three doses of a prototypic SARS-CoV-2 inactivated vaccine reduced viral loads in nasal, throat and anal swabs and pulmonary tissues and improved the pathological changes lungs of animals infected by variants of Alpha, Beta and Delta.
References: PMID: 35217639 / doi: 10.1038/s41392-022-00920-4
Contact Info: Zhongping Xie: [email protected]; Wenjie Tan: [email protected]
URL: https://www.nature.com/articles/s41392-022-00920-4
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences & Peking Union Medical College; National Institute for Viral Disease Control and Prevention
Keywords: SARS-CoV-2, inactivated vaccine, pathology, virus variants, primates
Summary of Study: Three doses of a prototypic SARS-CoV-2 inactivated vaccine reduced viral loads in nasal, throat and anal swabs and pulmonary tissues and improved the pathological changes lungs of animals infected by variants of Alpha, Beta and Delta.
References: PMID: 35217639 / doi: 10.1038/s41392-022-00920-4
Contact Info: Zhongping Xie: [email protected]; Wenjie Tan: [email protected]
URL: https://www.nature.com/articles/s41392-022-00920-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Michigan Technological University; Tulane University
Keywords: SARS-CoV-2, renin-angiotensin system, HIV co-infection, gene expression, primates
Summary of Study: Findings suggest a possible impact of SIV/HIV infection on expression of ACE2 and RAS-associated proteins resulting in the loss of gut homeostasis.
References: PMID: 35281029 / doi: 10.3389/fimmu.2022.835686
Contact Info: Bapi Pahar: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.835686/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Michigan Technological University; Tulane University
Keywords: SARS-CoV-2, renin-angiotensin system, HIV co-infection, gene expression, primates
Summary of Study: Findings suggest a possible impact of SIV/HIV infection on expression of ACE2 and RAS-associated proteins resulting in the loss of gut homeostasis.
References: PMID: 35281029 / doi: 10.3389/fimmu.2022.835686
Contact Info: Bapi Pahar: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.835686/full
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Université Paris-Saclay; Assistance Publique-Hôpitaux de Paris; Obesity Center, Department of Digestive, Oncologic and Metabolic Surgery, Institut Mutualiste Montsouris, Paris
Keywords: SARS-CoV-2, fat tissue, diagnostics, immunity, primates
Summary of Study: Subcutaneous adipose tissue (SCAT) is selectively infected by SARS-CoV-2 although changes in the immune properties of adispose tissue are observed in both SCAT and visceral adipose tissue
References: PMID: 35661814 PMCID: PMC9166782 DOI: 10.1038/s42003-022-03503-9
Contact Info: Christine Bourgeois: [email protected]
URL: https://www.nature.com/articles/s42003-022-03503-9
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Université Paris-Saclay; Assistance Publique-Hôpitaux de Paris; Obesity Center, Department of Digestive, Oncologic and Metabolic Surgery, Institut Mutualiste Montsouris, Paris
Keywords: SARS-CoV-2, fat tissue, diagnostics, immunity, primates
Summary of Study: Subcutaneous adipose tissue (SCAT) is selectively infected by SARS-CoV-2 although changes in the immune properties of adispose tissue are observed in both SCAT and visceral adipose tissue
References: PMID: 35661814 PMCID: PMC9166782 DOI: 10.1038/s42003-022-03503-9
Contact Info: Christine Bourgeois: [email protected]
URL: https://www.nature.com/articles/s42003-022-03503-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Wuhan Institute of Virology; Chinese Academy of Science; Wuhan National Biosafety Library, others
Keywords: SARS-CoV-2, testicular pathological damage, inflammation, primates
Summary of Study: SARS-CoV-2 infection induces testicular injury in Rhesus macaque
References: 10.1016/j.virs.2022.10.008
Contact Info: Z. Wuan: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1995820X22001833?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Wuhan Institute of Virology; Chinese Academy of Science; Wuhan National Biosafety Library, others
Keywords: SARS-CoV-2, testicular pathological damage, inflammation, primates
Summary of Study: SARS-CoV-2 infection induces testicular injury in Rhesus macaque
References: 10.1016/j.virs.2022.10.008
Contact Info: Z. Wuan: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1995820X22001833?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Emergent BioSolutions; Yoh Services LLC; Sanofi Pasteur; Translate Bio; UT Health Science Center at Houston
Keywords: SARS-CoV-2, virus variants, vaccine, boost, neutralizing effects, primates
Summary of Study: This study showed that a third vaccination administered as a booster, regardless of composition, to the currently approved two dose regimens could effectively promote broadly neutralizing antibodies against all variants of concern.
References: PMID: 35101265 / doi: 10.1016/j.vaccine.2022.01.021
Contact Info: Natalie Anosova: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22000457?via%3Dihub=
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Emergent BioSolutions; Yoh Services LLC; Sanofi Pasteur; Translate Bio; UT Health Science Center at Houston
Keywords: SARS-CoV-2, virus variants, vaccine, boost, neutralizing effects, primates
Summary of Study: This study showed that a third vaccination administered as a booster, regardless of composition, to the currently approved two dose regimens could effectively promote broadly neutralizing antibodies against all variants of concern.
References: PMID: 35101265 / doi: 10.1016/j.vaccine.2022.01.021
Contact Info: Natalie Anosova: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22000457?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: China Pharmaceutical University; Yunnan Walvax Biotech
Keywords: SARS-CoV-2, chimpanzee adenovirus-based vaccine, immunogenicity, toxicology, rats, primates
Summary of Study: AdC68-19S, a recombinant chimpanzee adenovirus serotype 68 vector-based vaccine encoding the full-length spike protein of SARS-CoV-2, induced an effective immune response with a good safety profile in rhesus macaques.
References: PMID: 35226134 / doi: 10.1007/s00204-021-03221-x
Contact Info: Zhen Huang: [email protected]
URL: https://link.springer.com/article/10.1007/s00204-021-03221-x
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: China Pharmaceutical University; Yunnan Walvax Biotech
Keywords: SARS-CoV-2, chimpanzee adenovirus-based vaccine, immunogenicity, toxicology, rats, primates
Summary of Study: AdC68-19S, a recombinant chimpanzee adenovirus serotype 68 vector-based vaccine encoding the full-length spike protein of SARS-CoV-2, induced an effective immune response with a good safety profile in rhesus macaques.
References: PMID: 35226134 / doi: 10.1007/s00204-021-03221-x
Contact Info: Zhen Huang: [email protected]
URL: https://link.springer.com/article/10.1007/s00204-021-03221-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beijing Institute of Microbiology and Epidemiology; Sinocelltech, Ltd.; Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, polysaccharide–protein-conjugated nanoparticle vaccine, virus variants, mice, rats, primates
Summary of Study: A novel nanoparticle vaccine was designed and prepared by chemically conjugating recombinant SARD-CoV-2 RBD and PPS14. Studies have demonstrated that SCTV01B vaccination induced potent and broad neutralizing antibodies and cellular immune responses against SARS-CoV-2 in mice, rats, and nonhuman primates, as well as high OPA against S. pneumoniae serotype 14.
References: PMID: 35332581 / doi: 10.1002/adma.202200443
Contact Info: Liangzhi Xie: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/adma.202200443
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beijing Institute of Microbiology and Epidemiology; Sinocelltech, Ltd.; Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, polysaccharide–protein-conjugated nanoparticle vaccine, virus variants, mice, rats, primates
Summary of Study: A novel nanoparticle vaccine was designed and prepared by chemically conjugating recombinant SARD-CoV-2 RBD and PPS14. Studies have demonstrated that SCTV01B vaccination induced potent and broad neutralizing antibodies and cellular immune responses against SARS-CoV-2 in mice, rats, and nonhuman primates, as well as high OPA against S. pneumoniae serotype 14.
References: PMID: 35332581 / doi: 10.1002/adma.202200443
Contact Info: Liangzhi Xie: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/adma.202200443
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Peking Union Medical College; National Center of Technology Innovation for Animal Model; Chinese Academy of Sciences; Capital Medical University
Keywords: SARS-CoV-2, inactivated vaccine, booster, immune response, virus variants, primates
Summary of Study: Animals administered with an indicated booster dose and subsequently challenged with Delta or Omicron variants showed markedly reduced viral loads and improved histopathological profiles compared to control animals, indicating that sequential immunization could protect primates against Omicron.
References: PMID: 35436986 / doi: 10.1038/s41392-022-00979-z
Contact Info: Chuan Qin: [email protected];
URL: https://www.nature.com/articles/s41392-022-00979-z
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Peking Union Medical College; National Center of Technology Innovation for Animal Model; Chinese Academy of Sciences; Capital Medical University
Keywords: SARS-CoV-2, inactivated vaccine, booster, immune response, virus variants, primates
Summary of Study: Animals administered with an indicated booster dose and subsequently challenged with Delta or Omicron variants showed markedly reduced viral loads and improved histopathological profiles compared to control animals, indicating that sequential immunization could protect primates against Omicron.
References: PMID: 35436986 / doi: 10.1038/s41392-022-00979-z
Contact Info: Chuan Qin: [email protected];
URL: https://www.nature.com/articles/s41392-022-00979-z
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Sun Yat-sen University; The First Affiliated Hospital of Guangzhou Medical University; Southern University of Science and Technology; The First Affiliated Hospital of Sun Yat-sen University; Guangdong Provincial Center for Disease Control and Prevention; Guangdong-Hong Kong Joint Laboratory for RNA Medicine
Keywords: SARS-CoV-2, quadrivalent mosaic HexaPro-bearing nanoparticle vaccine, virus variants, mice and primates
Summary of Study: A quadrivalent mosaic nanoparticle vaccine displaying spike proteins from the SARS-CoV-2 prototype and 3 different VOCs elicits equivalent or superior neutralizing antibodies against variant strains in mice and non-human primates with only small reduction in neutralization titers against the ancestral strain.
References: PMID: 35562337 / doi: 10.1038/s41467-022-30222-w
Contact Info: Jin-Cun Zhao: [email protected]; Run-Yu Yuan: [email protected]; Mu-Sheng Zeng: [email protected]
URL: https://www.nature.com/articles/s41467-022-30222-w
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Sun Yat-sen University; The First Affiliated Hospital of Guangzhou Medical University; Southern University of Science and Technology; The First Affiliated Hospital of Sun Yat-sen University; Guangdong Provincial Center for Disease Control and Prevention; Guangdong-Hong Kong Joint Laboratory for RNA Medicine
Keywords: SARS-CoV-2, quadrivalent mosaic HexaPro-bearing nanoparticle vaccine, virus variants, mice and primates
Summary of Study: A quadrivalent mosaic nanoparticle vaccine displaying spike proteins from the SARS-CoV-2 prototype and 3 different VOCs elicits equivalent or superior neutralizing antibodies against variant strains in mice and non-human primates with only small reduction in neutralization titers against the ancestral strain.
References: PMID: 35562337 / doi: 10.1038/s41467-022-30222-w
Contact Info: Jin-Cun Zhao: [email protected]; Run-Yu Yuan: [email protected]; Mu-Sheng Zeng: [email protected]
URL: https://www.nature.com/articles/s41467-022-30222-w
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Affinivax; Ragon Institute of MGH, MIT, and Harvard; Boston Children's Hospital
Keywords: SARS-CoV-2, multiple antigen-presenting system vaccine, pathology, primates
Summary of Study: Multiple Antigen-Presenting System is a novel way to create a vaccine presenting proteins on a polymer and is able to induce antibody formation and reduce viral load in NHPS.
References: PMID: 35891233 / doi: 10.3390/vaccines10071069
Contact Info: Gilles Besin: [email protected]
URL: https://www.mdpi.com/2076-393X/10/7/1069
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Affinivax; Ragon Institute of MGH, MIT, and Harvard; Boston Children's Hospital
Keywords: SARS-CoV-2, multiple antigen-presenting system vaccine, pathology, primates
Summary of Study: Multiple Antigen-Presenting System is a novel way to create a vaccine presenting proteins on a polymer and is able to induce antibody formation and reduce viral load in NHPS.
References: PMID: 35891233 / doi: 10.3390/vaccines10071069
Contact Info: Gilles Besin: [email protected]
URL: https://www.mdpi.com/2076-393X/10/7/1069
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Washington; Stanford University School of Medicine; University of Louisiana at Lafayette; Washington University School of Medicine
Keywords: SARS-CoV-2, vaccine, immune response, mice, primates
Summary of Study: Non-human primates and humans are better models than mice when looking at the potency of neutralizing antibody responses from vaccine as their immune and caution should be used when generalizing data from mouse models.
References: PMID: 35988541 / doi: 10.1016/j.celrep.2022.111299
Contact Info: David Veesler: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2211124722011196?via%3Dihub=
NHP Species: pigtail macaques, rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Washington; Stanford University School of Medicine; University of Louisiana at Lafayette; Washington University School of Medicine
Keywords: SARS-CoV-2, vaccine, immune response, mice, primates
Summary of Study: Non-human primates and humans are better models than mice when looking at the potency of neutralizing antibody responses from vaccine as their immune and caution should be used when generalizing data from mouse models.
References: PMID: 35988541 / doi: 10.1016/j.celrep.2022.111299
Contact Info: David Veesler: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2211124722011196?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Research Centre for Epidemiology and Microbiology; Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences; Sechenov First Moscow State Medical University
Keywords: SARS-CoV-2, vector-based heterologous vaccine, immune response, mice, primates
Summary of Study: Intranasal Sputnik V vaccine is a novel mucosal vaccine with immunogenic and protective properties identified by immunoglobin and neutralizing antibody production, antigen-specific T-cell response, and cytokine release.
References: PMID: 36031930 / doi: 10.1080/22221751.2022.2119169
Contact Info: Amir I. Tukhvatulin: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2119169
NHP Species: marmosets
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Research Centre for Epidemiology and Microbiology; Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences; Sechenov First Moscow State Medical University
Keywords: SARS-CoV-2, vector-based heterologous vaccine, immune response, mice, primates
Summary of Study: Intranasal Sputnik V vaccine is a novel mucosal vaccine with immunogenic and protective properties identified by immunoglobin and neutralizing antibody production, antigen-specific T-cell response, and cytokine release.
References: PMID: 36031930 / doi: 10.1080/22221751.2022.2119169
Contact Info: Amir I. Tukhvatulin: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2022.2119169
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: National Biodefense Analysis and Countermeasures Center; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health; Censeo Insight, Seattle, Washington, USA.
Keywords: SARS-CoV-2, dose–response relationships, aerosol, virus isolates, primates
Summary of Study: Provides dose response data important to inform disease transmission and hazard modeling
References: doi: 10.1089/jamp.2022.0043
Contact Info: Paul Dabisch: [email protected]
URL: https://www.liebertpub.com/doi/10.1089/jamp.2022.0043
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: National Biodefense Analysis and Countermeasures Center; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health; Censeo Insight, Seattle, Washington, USA.
Keywords: SARS-CoV-2, dose–response relationships, aerosol, virus isolates, primates
Summary of Study: Provides dose response data important to inform disease transmission and hazard modeling
References: doi: 10.1089/jamp.2022.0043
Contact Info: Paul Dabisch: [email protected]
URL: https://www.liebertpub.com/doi/10.1089/jamp.2022.0043
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Shiga University of Medical Science, Otsu, Japan; others
Keywords: SARS-CoV-2, vaccine development, attenuated vaccinia virus, immune response, proteomics, virus variants, mice, primates
Summary of Study: Vaccine protects monkeys and transgenic mice from SARS-CoV-2 and variants
References: doi: 10.3389/fmicb.2022.967019
Contact Info: Michinori Kohara: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2022.967019/full
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Shiga University of Medical Science, Otsu, Japan; others
Keywords: SARS-CoV-2, vaccine development, attenuated vaccinia virus, immune response, proteomics, virus variants, mice, primates
Summary of Study: Vaccine protects monkeys and transgenic mice from SARS-CoV-2 and variants
References: doi: 10.3389/fmicb.2022.967019
Contact Info: Michinori Kohara: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2022.967019/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: therapeutics
NPRC/Institute: Lovelace Biomedical; Gilead Sciences; Inspired - Pulmonary Solutions
Keywords: SARS-CoV-2, remdesivir, inhalation, viral load, pharmacokinetics, primates
Summary of Study: Inhaled remdesivir reduced viral load as compared with placebo in African green monkeys infected with SARS-CoV-2.
References: PMID: 34968150 / doi: 10.1126/scitranslmed.abl8282
Contact Info: Danielle Porter: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abl8282?url_ver=Z39.88-2003&rf…
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: therapeutics
NPRC/Institute: Lovelace Biomedical; Gilead Sciences; Inspired - Pulmonary Solutions
Keywords: SARS-CoV-2, remdesivir, inhalation, viral load, pharmacokinetics, primates
Summary of Study: Inhaled remdesivir reduced viral load as compared with placebo in African green monkeys infected with SARS-CoV-2.
References: PMID: 34968150 / doi: 10.1126/scitranslmed.abl8282
Contact Info: Danielle Porter: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abl8282?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: prevention
NPRC/Institute: University of Washington; Washington National Primate Research Center; Institute of Biomedical Sciences, Taipei; Fred Hutchinson Cancer Research Center
Keywords: SARS-CoV-2, helper-dependent adenovirus (HDAd5/35++), HSC gene therapy, safety, virus protection, mice, primates
Summary of Study: Pilot studies of a simple and portable in vivo hematopoietic HSC transduction approach that involves HSC mobilization from the bone marrow into the peripheral blood stream and the intravenous injection of an integrating, helper-dependent adenovirus vector system demonstrated safety and efficacy in mice and a rhesus macaque.
References: PMID: 35057635 / doi: 10.1089/hum.2021.295
Contact Info: Andre Lieber: [email protected]; Steve Roffler: [email protected]; Hans-Peter Kiem: [email protected]; Deborah Fuller: [email protected]
URL: https://www.liebertpub.com/doi/10.1089/hum.2021.295?url_ver=Z39.88-2003&rfr_id=…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: prevention
NPRC/Institute: University of Washington; Washington National Primate Research Center; Institute of Biomedical Sciences, Taipei; Fred Hutchinson Cancer Research Center
Keywords: SARS-CoV-2, helper-dependent adenovirus (HDAd5/35++), HSC gene therapy, safety, virus protection, mice, primates
Summary of Study: Pilot studies of a simple and portable in vivo hematopoietic HSC transduction approach that involves HSC mobilization from the bone marrow into the peripheral blood stream and the intravenous injection of an integrating, helper-dependent adenovirus vector system demonstrated safety and efficacy in mice and a rhesus macaque.
References: PMID: 35057635 / doi: 10.1089/hum.2021.295
Contact Info: Andre Lieber: [email protected]; Steve Roffler: [email protected]; Hans-Peter Kiem: [email protected]; Deborah Fuller: [email protected]
URL: https://www.liebertpub.com/doi/10.1089/hum.2021.295?url_ver=Z39.88-2003&rfr_id=…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Henry M. Jackson Foundation for the Advancement of Military Medicine; Washington University; NCI/NIH; Bioqual; Oak Ridge Institute of Science and Education; Columbia University Vagelos College of Physicians and Surgeons; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, nanoparticle vaccine, cellular and humoral immune responses, primates
Summary of Study: Nonhuman primates vaccinated with two doses of SpFN (a SARS-CoV-2 spike protein ferritin nanoparticle vaccine) were protected against SARS-CoV-2 challenge. SErum isolated from vaccinated animals neutralized several variants of concern, including the delta variant.
References: PMID: 39414540 / doi: 10.1126/scitranslmed.abi5735
Contact Info: M. Gordon Joyce: [email protected]; Kayvon Modjarrad: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abi5735
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Henry M. Jackson Foundation for the Advancement of Military Medicine; Washington University; NCI/NIH; Bioqual; Oak Ridge Institute of Science and Education; Columbia University Vagelos College of Physicians and Surgeons; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, nanoparticle vaccine, cellular and humoral immune responses, primates
Summary of Study: Nonhuman primates vaccinated with two doses of SpFN (a SARS-CoV-2 spike protein ferritin nanoparticle vaccine) were protected against SARS-CoV-2 challenge. SErum isolated from vaccinated animals neutralized several variants of concern, including the delta variant.
References: PMID: 39414540 / doi: 10.1126/scitranslmed.abi5735
Contact Info: M. Gordon Joyce: [email protected]; Kayvon Modjarrad: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abi5735
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: MIT; Scripps Research Institute; La Jolla Institute for Immunology; Ragon Institute of Massachusetts General Hospital, MIT, and Harvard University; University of California, San Diego; Yerkes National Primate Research Center; Emory University School of Medicine; MIT
Keywords: SARS-CoV-2, saponin/TLR agonist, vaccine adjuvant, immune response, primates
Summary of Study: Compared with a panel of tested adjuvants including other saponin-based formulations, saponin/MPLA nanoparticles (SMNP) induced superior antibody and germinal center responses after immunization with a poorly immunogenic HIV antigen in both mice and rhesus macaques, suggesting that SMNP may be a promising adjuvant in the setting of HIV, SARS-CoV-2, and other pathogens.
References: PMID: 34860581 / doi: 10.1126/sciimmunol.abf1152
Contact Info: Darrell J. Irvine: [email protected]; Shane Crotty: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.abf1152?url_ver=Z39.88-2003&rfr_…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: MIT; Scripps Research Institute; La Jolla Institute for Immunology; Ragon Institute of Massachusetts General Hospital, MIT, and Harvard University; University of California, San Diego; Yerkes National Primate Research Center; Emory University School of Medicine; MIT
Keywords: SARS-CoV-2, saponin/TLR agonist, vaccine adjuvant, immune response, primates
Summary of Study: Compared with a panel of tested adjuvants including other saponin-based formulations, saponin/MPLA nanoparticles (SMNP) induced superior antibody and germinal center responses after immunization with a poorly immunogenic HIV antigen in both mice and rhesus macaques, suggesting that SMNP may be a promising adjuvant in the setting of HIV, SARS-CoV-2, and other pathogens.
References: PMID: 34860581 / doi: 10.1126/sciimmunol.abf1152
Contact Info: Darrell J. Irvine: [email protected]; Shane Crotty: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.abf1152?url_ver=Z39.88-2003&rfr_…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Biomedical Primate Research Centre; Consejo Superior de Investigaciones Cientificas (CSIC); Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas (CIBERINFEC); Erasmus Medical Center; Instituto de Investigacion Hospital Universitario 12 de Octubre (imas12); Universidad Complutense School of Medicine, Biofabri
Keywords: SARS-CoV-2, vaccine, modified vaccinia virus Ankara vector, immune response, primates
Summary of Study: The MVA-S vaccine is safe and well tolerated in rhesus macaques, being highly immunogenic with the induction of potent levels of binding and neutralizing antibodies against several SARS-CoV-2 VOC, as well as Th1-skewed cell responses.
References: PMID: 35371043 / doi: 10.3389/fimmu.2022.845887
Contact Info: Petra Mooij: [email protected]; Juan Garcia-Arriaza: [email protected]; Gerrit Koopman: [email protected]; Mariano Esteban: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.845887/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Biomedical Primate Research Centre; Consejo Superior de Investigaciones Cientificas (CSIC); Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas (CIBERINFEC); Erasmus Medical Center; Instituto de Investigacion Hospital Universitario 12 de Octubre (imas12); Universidad Complutense School of Medicine, Biofabri
Keywords: SARS-CoV-2, vaccine, modified vaccinia virus Ankara vector, immune response, primates
Summary of Study: The MVA-S vaccine is safe and well tolerated in rhesus macaques, being highly immunogenic with the induction of potent levels of binding and neutralizing antibodies against several SARS-CoV-2 VOC, as well as Th1-skewed cell responses.
References: PMID: 35371043 / doi: 10.3389/fimmu.2022.845887
Contact Info: Petra Mooij: [email protected]; Juan Garcia-Arriaza: [email protected]; Gerrit Koopman: [email protected]; Mariano Esteban: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.845887/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Gritstone bio, Inc.; Battelle Biomedical Research Center
Keywords: SARS-CoV-2, self-amplifying mRNA vaccine, immune response, primates
Summary of Study: Report of the preclinical development of a strong self-amplifying mRNA (SAM) vaccine being evaluated in clinical trials as both a homologous prime-boost regimen at low doses and as a boost following heterologous prime
References: PMID: 35672369 PMCID: PMC9173840 DOI: 10.1038/s41467-022-31005-z
Contact Info: Karin Jooss: [email protected]
URL: https://www.nature.com/articles/s41467-022-31005-z
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Gritstone bio, Inc.; Battelle Biomedical Research Center
Keywords: SARS-CoV-2, self-amplifying mRNA vaccine, immune response, primates
Summary of Study: Report of the preclinical development of a strong self-amplifying mRNA (SAM) vaccine being evaluated in clinical trials as both a homologous prime-boost regimen at low doses and as a boost following heterologous prime
References: PMID: 35672369 PMCID: PMC9173840 DOI: 10.1038/s41467-022-31005-z
Contact Info: Karin Jooss: [email protected]
URL: https://www.nature.com/articles/s41467-022-31005-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Center for Genetic Engineering and Biotechnology; Civilian Defense Scienti?c Research Center, Carretera de Jamaica y Autopista Nacional; Biotechnology and Pharmaceutical Industries Group, BioCubaFarma, Ave; Latin American School of Medicine
Keywords: SARS-CoV-2, vaccine, yeast, manufacturing, mice, primates
Summary of Study: The COVID-19 receptor-binding domain produced in yeast cells can be modified by adding amino acids in order to create a possible vaccine candidate due to its ability to stimulate anti-inflammatory cells and inhibit binding to ACE2.
References: PMID: 35953030 / doi: 10.1016/j.nbt.2022.08.002
Contact Info: Gerardo Guillén-Nieto: Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Ave. 31 E/ 158 y 190, La Habana 10600, Cuba
URL: https://www.sciencedirect.com/science/article/pii/S1871678422000462?via%3Dihub=
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Center for Genetic Engineering and Biotechnology; Civilian Defense Scienti?c Research Center, Carretera de Jamaica y Autopista Nacional; Biotechnology and Pharmaceutical Industries Group, BioCubaFarma, Ave; Latin American School of Medicine
Keywords: SARS-CoV-2, vaccine, yeast, manufacturing, mice, primates
Summary of Study: The COVID-19 receptor-binding domain produced in yeast cells can be modified by adding amino acids in order to create a possible vaccine candidate due to its ability to stimulate anti-inflammatory cells and inhibit binding to ACE2.
References: PMID: 35953030 / doi: 10.1016/j.nbt.2022.08.002
Contact Info: Gerardo Guillén-Nieto: Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Ave. 31 E/ 158 y 190, La Habana 10600, Cuba
URL: https://www.sciencedirect.com/science/article/pii/S1871678422000462?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIBSC Division of Infectious Disease Diagnostics, Division of Virology, Division of Analytical and Biological Sciences, other, Hertfordshire, UK
Keywords: SARS-CoV-2, virology, molecular and pathological outcomes, several animal species, primates
Summary of Study: Viral outcomes in multiple species
References: doi: 10.1038/s41598-022-23339-x
Contact Info: Neil Berry: [email protected]
URL: https://www.nature.com/articles/s41598-022-23339-x
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIBSC Division of Infectious Disease Diagnostics, Division of Virology, Division of Analytical and Biological Sciences, other, Hertfordshire, UK
Keywords: SARS-CoV-2, virology, molecular and pathological outcomes, several animal species, primates
Summary of Study: Viral outcomes in multiple species
References: doi: 10.1038/s41598-022-23339-x
Contact Info: Neil Berry: [email protected]
URL: https://www.nature.com/articles/s41598-022-23339-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Fudan University; The University of Hong Kong; Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park; Graduate School of Peking Union Medical College; National Institute for Food and Drug Control, Beijing, China; Fulgent Pharma LLC
Keywords: SARS-CoV-2, pan-sarbecovirus vaccine, immune response, virus variants, primates
Summary of Study: A pan-sarbecovirus vaccine consisting of human IgG Fc fragment-conjugated RBC of the original SARS-CoV-2 WA1 strain as the immunogen and a novel small-molecule non-nucleotide STING agonist as the adjuvant could be used to prevent infection by the current SARS-CoV-2 variants, including Omicron, and future emerging sarbecoviruses.
References: PMID: 35210607 / doi: 10. 1038/s41422-022-00631-z
Contact Info: Youchun Wang: [email protected]
URL: https://www.nature.com/articles/s41422-022-00631-z
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Fudan University; The University of Hong Kong; Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park; Graduate School of Peking Union Medical College; National Institute for Food and Drug Control, Beijing, China; Fulgent Pharma LLC
Keywords: SARS-CoV-2, pan-sarbecovirus vaccine, immune response, virus variants, primates
Summary of Study: A pan-sarbecovirus vaccine consisting of human IgG Fc fragment-conjugated RBC of the original SARS-CoV-2 WA1 strain as the immunogen and a novel small-molecule non-nucleotide STING agonist as the adjuvant could be used to prevent infection by the current SARS-CoV-2 variants, including Omicron, and future emerging sarbecoviruses.
References: PMID: 35210607 / doi: 10. 1038/s41422-022-00631-z
Contact Info: Youchun Wang: [email protected]
URL: https://www.nature.com/articles/s41422-022-00631-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tsinghua University; Chongqing Medical University; Boston University School of Medicine; Chinese Academy of Sciences; Shenzhen Bay Laboratory; Peking University Shenshen Graduate School; Fudan University
Keywords: SARS-CoV-2, pathogenesis, neutralization antibodies, primates
Summary of Study: Kappa, Delta, or B.1.618 spike uses human angiotensin-converting enzyme 2 (ACE2) with no or slightly increased efficiency, while it gains a significantly increased binding affinity with mouse, marmoset, and koala ACE2 orthologs, which exhibit limited binding with wild-type (WT) spike. Collectively, this study revealed that enhanced human and mouse ASE receptor engagement, increased spike cleavage, and reduced sensitivity to neutralization antibodies of Kapa, Delta and B.1.618 may contribute to the rapid spread of these variants.
References: PMID: 35266815 / doi: 10.1128/mbio.00099-22
Contact Info: Qiang Ding: [email protected]
URL: https://journals.asm.org/doi/full/10.1128/mbio.00099-22?rfr_dat=cr_pub%20%200pu…
NHP Species: marmosets
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tsinghua University; Chongqing Medical University; Boston University School of Medicine; Chinese Academy of Sciences; Shenzhen Bay Laboratory; Peking University Shenshen Graduate School; Fudan University
Keywords: SARS-CoV-2, pathogenesis, neutralization antibodies, primates
Summary of Study: Kappa, Delta, or B.1.618 spike uses human angiotensin-converting enzyme 2 (ACE2) with no or slightly increased efficiency, while it gains a significantly increased binding affinity with mouse, marmoset, and koala ACE2 orthologs, which exhibit limited binding with wild-type (WT) spike. Collectively, this study revealed that enhanced human and mouse ASE receptor engagement, increased spike cleavage, and reduced sensitivity to neutralization antibodies of Kapa, Delta and B.1.618 may contribute to the rapid spread of these variants.
References: PMID: 35266815 / doi: 10.1128/mbio.00099-22
Contact Info: Qiang Ding: [email protected]
URL: https://journals.asm.org/doi/full/10.1128/mbio.00099-22?rfr_dat=cr_pub%20%200pu…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane School of Medicine
Keywords: SARS-CoV-2, monoclonal antibody prophylaxis, virus reproduction, primates
Summary of Study: High viral loads were observed in the intestinal mucosa of a rhesus macaque post challenge with SARS-CoV-2 after prophylactic administration of combination anti-spike antibody therapy. Intrahost evolution of virus was seen, with sequences changing in accordance with enhanced replication capacity, as well as site-specific differences potentially indicating preferential replication.
References: PMID: 35429402 / doi: 10.1093/infdis/jiac134
Contact Info: Chad Roy: [email protected]
URL: https://academic.oup.com/jid/article/226/9/1588/6569365?login=false
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane School of Medicine
Keywords: SARS-CoV-2, monoclonal antibody prophylaxis, virus reproduction, primates
Summary of Study: High viral loads were observed in the intestinal mucosa of a rhesus macaque post challenge with SARS-CoV-2 after prophylactic administration of combination anti-spike antibody therapy. Intrahost evolution of virus was seen, with sequences changing in accordance with enhanced replication capacity, as well as site-specific differences potentially indicating preferential replication.
References: PMID: 35429402 / doi: 10.1093/infdis/jiac134
Contact Info: Chad Roy: [email protected]
URL: https://academic.oup.com/jid/article/226/9/1588/6569365?login=false
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: USAMRIID
Keywords: SARS-CoV-2, routes of exposure, pathology, primates
Summary of Study: Cynomolgus macaques may be the better model for SARS-CoV-2 than RM, as these animals had the most severe and consistent disease presentation.
References: PMID: 35632755 / doi: 10.3390/v14051013
Contact Info: Jay Hooper: [email protected]; Jeffrey Koehler: [email protected]; Charles Shoemaker: [email protected]; Tamara Clements: [email protected]; Alexandra Jay: [email protected]
URL: https://www.mdpi.com/1999-4915/14/5/1013
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: USAMRIID
Keywords: SARS-CoV-2, routes of exposure, pathology, primates
Summary of Study: Cynomolgus macaques may be the better model for SARS-CoV-2 than RM, as these animals had the most severe and consistent disease presentation.
References: PMID: 35632755 / doi: 10.3390/v14051013
Contact Info: Jay Hooper: [email protected]; Jeffrey Koehler: [email protected]; Charles Shoemaker: [email protected]; Tamara Clements: [email protected]; Alexandra Jay: [email protected]
URL: https://www.mdpi.com/1999-4915/14/5/1013
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Zalgen Labs, LLC; Duke University Medical Center, Duke Human Vaccine Institute;
Keywords: SARS-CoV-2, viral kinetics, immune response, primates
Summary of Study: Pulmonary outcome of COVID-19 is not influenced by route of infection even though clinical onset shows differences.
References: PMID: 35789343 / doi: 10.1371/journal.ppat.1010618
Contact Info: Chad Roy: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010618
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Zalgen Labs, LLC; Duke University Medical Center, Duke Human Vaccine Institute;
Keywords: SARS-CoV-2, viral kinetics, immune response, primates
Summary of Study: Pulmonary outcome of COVID-19 is not influenced by route of infection even though clinical onset shows differences.
References: PMID: 35789343 / doi: 10.1371/journal.ppat.1010618
Contact Info: Chad Roy: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010618
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Stanford University; University of Washington; Emory National Primate Research Center, and Emory University School of Medicine; Tulane National Primate Research Center; University of Louisiana at Lafayette; University of Maryland School of Medicine; University of California, San Diego; La Jolla Institute for Immunology; GSK; Bill and Melinda Gates Foundation; Tulane University School of Medicine;
Keywords: SARS-CoV-2, adjuvanted subunit vaccine, immune response, primates
Summary of Study: An adjuvanted subunit vaccine results in significant and durable memory T- and B-cell responses to Beta and Omicron variants and was found to suppress viral load and protect lungs after Omicron infection.
References: PMID: 35976993 / doi: 10.1126/scitranslmed.abq4130
Contact Info: Bali Pulendran: [email protected]
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abq4130?rfr_dat=cr_pub%20…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Stanford University; University of Washington; Emory National Primate Research Center, and Emory University School of Medicine; Tulane National Primate Research Center; University of Louisiana at Lafayette; University of Maryland School of Medicine; University of California, San Diego; La Jolla Institute for Immunology; GSK; Bill and Melinda Gates Foundation; Tulane University School of Medicine;
Keywords: SARS-CoV-2, adjuvanted subunit vaccine, immune response, primates
Summary of Study: An adjuvanted subunit vaccine results in significant and durable memory T- and B-cell responses to Beta and Omicron variants and was found to suppress viral load and protect lungs after Omicron infection.
References: PMID: 35976993 / doi: 10.1126/scitranslmed.abq4130
Contact Info: Bali Pulendran: [email protected]
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abq4130?rfr_dat=cr_pub%20…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: California National Primate Research Center; University of California, Davis
Keywords: SARS-CoV-2, surveillance, diagnostics, multi-antigen assays , RT-PCR, primates
Summary of Study: Colony management practices including restricted access, PPE, personnel vaccination and testing requirements have been adequate to prevent the spread of COVID-19 within the CNPRC NHP colony along with developing multi-antigen assays to survey the population.
References: PMID: 35794847 / doi: 10.1111/jmp.12604
Contact Info: JoAnn Yee: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1111/jmp.12604
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: California National Primate Research Center; University of California, Davis
Keywords: SARS-CoV-2, surveillance, diagnostics, multi-antigen assays , RT-PCR, primates
Summary of Study: Colony management practices including restricted access, PPE, personnel vaccination and testing requirements have been adequate to prevent the spread of COVID-19 within the CNPRC NHP colony along with developing multi-antigen assays to survey the population.
References: PMID: 35794847 / doi: 10.1111/jmp.12604
Contact Info: JoAnn Yee: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1111/jmp.12604
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; CureVac AG, Tübingen, Germany
Keywords: SARS-CoV-2, unmodified mRNA vaccine, CVnCoV, immune response, primates
Summary of Study: A third dose of the unmodified COVID-19 mRNA vaccine CVnCoV enhances quality and quantity of immune responses.
References: doi: 10.1016/j.omtm.2022.10.001
Contact Info: Karin Loré: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2329050122001437?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; CureVac AG, Tübingen, Germany
Keywords: SARS-CoV-2, unmodified mRNA vaccine, CVnCoV, immune response, primates
Summary of Study: A third dose of the unmodified COVID-19 mRNA vaccine CVnCoV enhances quality and quantity of immune responses.
References: doi: 10.1016/j.omtm.2022.10.001
Contact Info: Karin Loré: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2329050122001437?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chin Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, China
Keywords: SARS-CoV-2, review, traditional Chinese medicine, mice, hamsters, primates
Summary of Study: Model exploration for discovering COVID-19 targeted traditional Chinese medicine
References: doi: 10.1016/j.heliyon.2022.e12333
Contact Info: Fengmei Lian: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2405844022036210?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chin Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, China
Keywords: SARS-CoV-2, review, traditional Chinese medicine, mice, hamsters, primates
Summary of Study: Model exploration for discovering COVID-19 targeted traditional Chinese medicine
References: doi: 10.1016/j.heliyon.2022.e12333
Contact Info: Fengmei Lian: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2405844022036210?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Washington University; National Cancer Institute/NIH; Bioqual; Oak Ridge Institute of Science & Education; Columbia University Vagelos College of Physicians and Surgeons; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, spike protein ferritin nanoparticle (SpFN) vaccine, immune response, primates
Summary of Study: NHPs vaccinated with two doses of SpFN plus adjuvant separated by 28 days developed potent SARS-CoV-2-specific B and T cell responses, which conferred protection against SARS-CoV-2 challenge.
References: PMID: 34914540 / doi: 10.1126/scitranslmed.abi5735
Contact Info: Kayvon Modjarrad: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abi5735?url_ver=Z39.88-2003&rf…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Washington University; National Cancer Institute/NIH; Bioqual; Oak Ridge Institute of Science & Education; Columbia University Vagelos College of Physicians and Surgeons; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, spike protein ferritin nanoparticle (SpFN) vaccine, immune response, primates
Summary of Study: NHPs vaccinated with two doses of SpFN plus adjuvant separated by 28 days developed potent SARS-CoV-2-specific B and T cell responses, which conferred protection against SARS-CoV-2 challenge.
References: PMID: 34914540 / doi: 10.1126/scitranslmed.abi5735
Contact Info: Kayvon Modjarrad: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abi5735?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Zhongshan School of Medicine; Qianyang Biomedical Research Institute; Guangdong Provincial Center for Disease Control and Prevention
Keywords: SARS-CoV-2, bivalent vaccine, D614G/B.1.351, vaccine dosage, mice, primates
Summary of Study: With a prime-boost or single-dose strategy a bivalent D614G/B.1.351 RBD nanoparticle vaccine elicited robust nAbs and full protection against infection with the authentic D614 or B.1.351 strains in human ACE2 transgene mice. Furthermore, 8 months after inoculation with the D614G-specific vaccine, a new boost with this bivalent vaccine potently elicited cross-nAbs for SARS-CoV-2 variants in rhesus macaques.
References: PMID: 34990583 / doi: 10.1016/j.celrep.2021.110256
Contact Info: Yiwen Zhang: [email protected]; Hui Zhang: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S221112472101768X?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Zhongshan School of Medicine; Qianyang Biomedical Research Institute; Guangdong Provincial Center for Disease Control and Prevention
Keywords: SARS-CoV-2, bivalent vaccine, D614G/B.1.351, vaccine dosage, mice, primates
Summary of Study: With a prime-boost or single-dose strategy a bivalent D614G/B.1.351 RBD nanoparticle vaccine elicited robust nAbs and full protection against infection with the authentic D614 or B.1.351 strains in human ACE2 transgene mice. Furthermore, 8 months after inoculation with the D614G-specific vaccine, a new boost with this bivalent vaccine potently elicited cross-nAbs for SARS-CoV-2 variants in rhesus macaques.
References: PMID: 34990583 / doi: 10.1016/j.celrep.2021.110256
Contact Info: Yiwen Zhang: [email protected]; Hui Zhang: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S221112472101768X?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Institute de Biologie Structurale; Universite Paris-Saclay, Inserm, CEA; Amsterdam University Medical Centers; Institute Pasteur, Universite de Paris; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, vaccine candidate, synthetic spike (S) glycoprotein-coated lipid vesicles, immune response, primates
Summary of Study: Immunization of cynomolgus macaques with S coated onto lipid vesicles (S-LVs) induces high antibody titers with potent neutralizing activity against the vaccine strain, Alpha, Beta, and Gamma variants as well as T helper (Th)1 CD4+-biased T cell responses.
References: PMID: 35233549 / doi: 10.1016/j.xcrm.2022.100528
Contact Info: Winfried Weissenhorn: [email protected]; Roger Le Grand: [email protected]
URL: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00028-3?_retu…
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Institute de Biologie Structurale; Universite Paris-Saclay, Inserm, CEA; Amsterdam University Medical Centers; Institute Pasteur, Universite de Paris; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, vaccine candidate, synthetic spike (S) glycoprotein-coated lipid vesicles, immune response, primates
Summary of Study: Immunization of cynomolgus macaques with S coated onto lipid vesicles (S-LVs) induces high antibody titers with potent neutralizing activity against the vaccine strain, Alpha, Beta, and Gamma variants as well as T helper (Th)1 CD4+-biased T cell responses.
References: PMID: 35233549 / doi: 10.1016/j.xcrm.2022.100528
Contact Info: Winfried Weissenhorn: [email protected]; Roger Le Grand: [email protected]
URL: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00028-3?_retu…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; China National Center for Bioinformation; Capital Medical University; Chinese Academy of Medical Sciences and Peking Union Medical College; Huazhong University of Science & Technology
Keywords: SARS-CoV-2, transcriptomic profiling, virus replication, primates
Summary of Study: This study provides the transcriptome profiling of various tissues from the living primate host post SARS-CoV-2 infection. It illustrates that wide-spread transcriptomic changes involving diverse functions exist in multi-organs; an elevated immune response in cerebral cortex was the prominent feature at the early stage of SARS-CoV-2 infection.
References: PMID: 35377064 / doi: 10.1007/s13238-022-00915-5
Contact Info: Ying Yang: [email protected]; Yun-Gui Yang: [email protected]; Chuan Qin: [email protected]; Wei-Min Tong: [email protected]
URL: https://link.springer.com/article/10.1007/s13238-022-00915-5
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; China National Center for Bioinformation; Capital Medical University; Chinese Academy of Medical Sciences and Peking Union Medical College; Huazhong University of Science & Technology
Keywords: SARS-CoV-2, transcriptomic profiling, virus replication, primates
Summary of Study: This study provides the transcriptome profiling of various tissues from the living primate host post SARS-CoV-2 infection. It illustrates that wide-spread transcriptomic changes involving diverse functions exist in multi-organs; an elevated immune response in cerebral cortex was the prominent feature at the early stage of SARS-CoV-2 infection.
References: PMID: 35377064 / doi: 10.1007/s13238-022-00915-5
Contact Info: Ying Yang: [email protected]; Yun-Gui Yang: [email protected]; Chuan Qin: [email protected]; Wei-Min Tong: [email protected]
URL: https://link.springer.com/article/10.1007/s13238-022-00915-5
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Sanofi R&D; Universite de Strasbourg; Equipe 3Bio
Keywords: SARS-CoV-2, mRNA vaccine, lipid nanoparticles, stability, mice, primates
Summary of Study: The thermostability of mRNA/LNP is improved by a novel imidazole modified lipid, DOG-IM4, in combination with standard helper lipids.
References: PMID: 35576809 / doi: 10.1016/j.biomaterials.2022.121570
Contact Info: Jean Haensler: [email protected];
URL: https://www.sciencedirect.com/science/article/pii/S0142961222002101?via%3Dihub=
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Sanofi R&D; Universite de Strasbourg; Equipe 3Bio
Keywords: SARS-CoV-2, mRNA vaccine, lipid nanoparticles, stability, mice, primates
Summary of Study: The thermostability of mRNA/LNP is improved by a novel imidazole modified lipid, DOG-IM4, in combination with standard helper lipids.
References: PMID: 35576809 / doi: 10.1016/j.biomaterials.2022.121570
Contact Info: Jean Haensler: [email protected];
URL: https://www.sciencedirect.com/science/article/pii/S0142961222002101?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: Departments of Biochemistry and Pathology & Laboratory Medicine, Bhopal, India
Keywords: SARS-CoV-2, review, animal models, infection, pathology, primates
Summary of Study: Review of the immunological and clinical manifestations observed in various natural and genetically-modified animal models of numerous COVID-19 studies. The authors also summarize up-to-date laboratory findings on available and significant COVID-19 animal models, and put forth their perspective for the objective dependent usage of animal models.
References: PMID: 35757923 DOI: 10.1080/08830185.2022.2089666
Contact Info: Ashok Kumar: [email protected]
URL: https://www.tandfonline.com/doi/abs/10.1080/08830185.2022.2089666?journalCode=i…
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: Departments of Biochemistry and Pathology & Laboratory Medicine, Bhopal, India
Keywords: SARS-CoV-2, review, animal models, infection, pathology, primates
Summary of Study: Review of the immunological and clinical manifestations observed in various natural and genetically-modified animal models of numerous COVID-19 studies. The authors also summarize up-to-date laboratory findings on available and significant COVID-19 animal models, and put forth their perspective for the objective dependent usage of animal models.
References: PMID: 35757923 DOI: 10.1080/08830185.2022.2089666
Contact Info: Ashok Kumar: [email protected]
URL: https://www.tandfonline.com/doi/abs/10.1080/08830185.2022.2089666?journalCode=i…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Ragon Institute of MGH, MIT, and Harvard; University of Massachusetts; Bioqual
Keywords: SARS-CoV-2, adenovirus vector–based vaccine Ad26.COV2.S, immune response, primates
Summary of Study: Cytotoxic T-cells that are vaccine induced contribute to virus control, and when depleted, higher viral loads are seen in the respiratory tract.
References: PMID: 35943359 / doi: 10.1126/sciimmunol.abq7647
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/full/10.1126/sciimmunol.abq7647?rfr_dat=cr_pub%20%2…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Ragon Institute of MGH, MIT, and Harvard; University of Massachusetts; Bioqual
Keywords: SARS-CoV-2, adenovirus vector–based vaccine Ad26.COV2.S, immune response, primates
Summary of Study: Cytotoxic T-cells that are vaccine induced contribute to virus control, and when depleted, higher viral loads are seen in the respiratory tract.
References: PMID: 35943359 / doi: 10.1126/sciimmunol.abq7647
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/full/10.1126/sciimmunol.abq7647?rfr_dat=cr_pub%20%2…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID RNA Viruses Section, Laboratory of Infectious Diseases, numerous others
Keywords: SARS-CoV-2, pediatric vaccine, live-attenuated parainfluenza-virus-vectored vaccine, immunogenicity, primates
Summary of Study: Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine is protective in monkeys
References: doi: 10.1016/j.cell.2022.11.006
Contact Info: Ursula Buchholz: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0092867422014180?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID RNA Viruses Section, Laboratory of Infectious Diseases, numerous others
Keywords: SARS-CoV-2, pediatric vaccine, live-attenuated parainfluenza-virus-vectored vaccine, immunogenicity, primates
Summary of Study: Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine is protective in monkeys
References: doi: 10.1016/j.cell.2022.11.006
Contact Info: Ursula Buchholz: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0092867422014180?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center, Texas Biomedical Research Institute; Washington University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, longitudinal scRNAseq, bronchoalveolar lavage, immune response, primates
Summary of Study: Results unequivocally show that in protected, immunocompetent hosts, SARS-CoV-2 infection is characterized by an acute inflammatory response leading to a myeloid cell influx into the lung compartment. Induction of a robust IFN response in macrophages strongly correlates with viremia and subsequent clearance of SARS-CoV-2 from the airways of macaques.
References: PMID: 35115549 / doi: 10.1038/s41467-022-28315-7
Contact Info: Maxim Artyomov: [email protected]
URL: https://www.nature.com/articles/s41467-022-28315-7
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center, Texas Biomedical Research Institute; Washington University; Tulane National Primate Research Center
Keywords: SARS-CoV-2, longitudinal scRNAseq, bronchoalveolar lavage, immune response, primates
Summary of Study: Results unequivocally show that in protected, immunocompetent hosts, SARS-CoV-2 infection is characterized by an acute inflammatory response leading to a myeloid cell influx into the lung compartment. Induction of a robust IFN response in macrophages strongly correlates with viremia and subsequent clearance of SARS-CoV-2 from the airways of macaques.
References: PMID: 35115549 / doi: 10.1038/s41467-022-28315-7
Contact Info: Maxim Artyomov: [email protected]
URL: https://www.nature.com/articles/s41467-022-28315-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Sun Yat-sen University; Guangdong Academy of Medical Sciences; Qianyang Biomedical Research Institute; Guangdong Provincial Center for Disease Control and Prevention
Keywords: SARS-CoV-2, Receptor Binding Domain (RBD)-Conjugated Nanoparticle Vaccine, virus variants, hACE2 mice, primates
Summary of Study: RBD-based monovalent or multivalent nanoparticle vaccines provide a promising second-generation vaccine strategy for SARS-CoV-2 variants.
References: PMID: 35142444 / doi: 10.1002/advs.202105378
Contact Info: Ting Pan: [email protected]; Hui Zhang: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008796/
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Sun Yat-sen University; Guangdong Academy of Medical Sciences; Qianyang Biomedical Research Institute; Guangdong Provincial Center for Disease Control and Prevention
Keywords: SARS-CoV-2, Receptor Binding Domain (RBD)-Conjugated Nanoparticle Vaccine, virus variants, hACE2 mice, primates
Summary of Study: RBD-based monovalent or multivalent nanoparticle vaccines provide a promising second-generation vaccine strategy for SARS-CoV-2 variants.
References: PMID: 35142444 / doi: 10.1002/advs.202105378
Contact Info: Ting Pan: [email protected]; Hui Zhang: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008796/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Universite Paris-Saclay, Inserm, CEA; University of Amsterdam; Grousbeck Gene Therapy Center; Harvard Medical School; The Broad Institute of Harvard and MIT; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, computed X-ray tomography and [18F]-FDG positron emission tomography, pathology, primates
Summary of Study: CT, combined with [18F]-FDG PET imaging, to study SARS-CoV-2 infected NHPs, can produce strong and transposable readouts to monitor COVID-19 disease as well as the efficacy of future treatments and vaccine candidates.
References: PMID: 35313622 / doi: 10.1016/j.isci.2022.104101
Contact Info: Thibaut Naninck: [email protected]
URL: https://www.cell.com/iscience/fulltext/S2589-0042(22)00371-6?_returnURL=https%3…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Universite Paris-Saclay, Inserm, CEA; University of Amsterdam; Grousbeck Gene Therapy Center; Harvard Medical School; The Broad Institute of Harvard and MIT; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, computed X-ray tomography and [18F]-FDG positron emission tomography, pathology, primates
Summary of Study: CT, combined with [18F]-FDG PET imaging, to study SARS-CoV-2 infected NHPs, can produce strong and transposable readouts to monitor COVID-19 disease as well as the efficacy of future treatments and vaccine candidates.
References: PMID: 35313622 / doi: 10.1016/j.isci.2022.104101
Contact Info: Thibaut Naninck: [email protected]
URL: https://www.cell.com/iscience/fulltext/S2589-0042(22)00371-6?_returnURL=https%3…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of California, Davis, School of Medicine
Keywords: SARS-CoV-2, pre-existing HIV infection, gene expression, metabolomics, primates
Summary of Study: SIV infection resulted in sustained or increased ACE2 expression in an inflamed and immune-impaired gut mucosal microenvironment.
References: PMID: 35495669 / doi: 10.3389/fmicb.2022.879152
Contact Info: Satya Dandekar: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2022.879152/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of California, Davis, School of Medicine
Keywords: SARS-CoV-2, pre-existing HIV infection, gene expression, metabolomics, primates
Summary of Study: SIV infection resulted in sustained or increased ACE2 expression in an inflamed and immune-impaired gut mucosal microenvironment.
References: PMID: 35495669 / doi: 10.3389/fmicb.2022.879152
Contact Info: Satya Dandekar: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2022.879152/full
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: The Broad Institute of Harvard and MIT; Harvard University; Universite Paris-Saclay, Inserm, CEA; Genethon INTEGRARE UMR; Rega Institute; University of Siena; University of Pennsylvania
Keywords: SARS-CoV-2, AAV-based vaccine, virus variants, immune response, mice, primates
Summary of Study: AAV-based vaccines for COVID-19 can be effective from a single, low dose and lead to durable humoral and strong T cell immunogenicity.
References: PMID: 35546782 / doi: 10.1016/j.ymthe.2022.05.007
Contact Info: Luk Vandenberghe: [email protected]
URL: https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-…
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: The Broad Institute of Harvard and MIT; Harvard University; Universite Paris-Saclay, Inserm, CEA; Genethon INTEGRARE UMR; Rega Institute; University of Siena; University of Pennsylvania
Keywords: SARS-CoV-2, AAV-based vaccine, virus variants, immune response, mice, primates
Summary of Study: AAV-based vaccines for COVID-19 can be effective from a single, low dose and lead to durable humoral and strong T cell immunogenicity.
References: PMID: 35546782 / doi: 10.1016/j.ymthe.2022.05.007
Contact Info: Luk Vandenberghe: [email protected]
URL: https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: GigaGen, Inc.; Alira Health, Inc.; Grifols S.A.; Vitalant Research Institute; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, drugs, GMP, clinical manufacturing, therapy, mice, primates
Summary of Study: A novel class of drugs, recombinant hyperimmune globulins are a safe and protective possible treatment to COVID-19 that could be made through large-scale production.
References: PMID: 35890050 / doi: 10.3390/pathogens11070806
Contact Info: Adam Adler: [email protected]
URL: https://www.mdpi.com/2076-0817/11/7/806
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: GigaGen, Inc.; Alira Health, Inc.; Grifols S.A.; Vitalant Research Institute; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, drugs, GMP, clinical manufacturing, therapy, mice, primates
Summary of Study: A novel class of drugs, recombinant hyperimmune globulins are a safe and protective possible treatment to COVID-19 that could be made through large-scale production.
References: PMID: 35890050 / doi: 10.3390/pathogens11070806
Contact Info: Adam Adler: [email protected]
URL: https://www.mdpi.com/2076-0817/11/7/806