Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of California, Davis, School of Medicine
Keywords: SARS-CoV-2, pre-existing HIV infection, gene expression, metabolomics, primates
Summary of Study: SIV infection resulted in sustained or increased ACE2 expression in an inflamed and immune-impaired gut mucosal microenvironment.
References: PMID: 35495669 / doi: 10.3389/fmicb.2022.879152
Contact Info: Satya Dandekar: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2022.879152/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of California, Davis, School of Medicine
Keywords: SARS-CoV-2, pre-existing HIV infection, gene expression, metabolomics, primates
Summary of Study: SIV infection resulted in sustained or increased ACE2 expression in an inflamed and immune-impaired gut mucosal microenvironment.
References: PMID: 35495669 / doi: 10.3389/fmicb.2022.879152
Contact Info: Satya Dandekar: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2022.879152/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Central Florida; Tulane National Primate Research Center
Keywords: SARS-CoV-2, pathology, heart, immune response, primates
Summary of Study: SARS-CoV-2 infection is characterized by an exaggerated inflammatory immune response in the heart, which possibly contributes to myocardial remodeling and subsequent fibrosis.
References: PMID: 35203260 / doi: 10.3390/cells11040611
Contact Info: Manish Kumar Gupta: [email protected]
URL: https://www.mdpi.com/2073-4409/11/4/611
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Central Florida; Tulane National Primate Research Center
Keywords: SARS-CoV-2, pathology, heart, immune response, primates
Summary of Study: SARS-CoV-2 infection is characterized by an exaggerated inflammatory immune response in the heart, which possibly contributes to myocardial remodeling and subsequent fibrosis.
References: PMID: 35203260 / doi: 10.3390/cells11040611
Contact Info: Manish Kumar Gupta: [email protected]
URL: https://www.mdpi.com/2073-4409/11/4/611
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Ology Bioservices; Harvard Medical School, Vanderbilt University Medical Center; US Department of Defense; Logistics Management Institute; Washington University School of Medicine; Bioqual, Inc.
Keywords: SARS-CoV-2, neutralizing human monoclonal antibodies, primates
Summary of Study: Neutralizing antibodies with extended half-life and lacking Fc-mediated effector functions are efficient for pre-exposure prophylaxis of SARS-CoV-2 infection in NHPs.
References: PMID: 35132398 / doi: 10.1016/j.medj.2022.01.004
Contact Info: Dan Barouch: [email protected]
URL: https://www.cell.com/med/fulltext/S2666-6340(22)00039-3?_returnURL=https%3A//li…
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Ology Bioservices; Harvard Medical School, Vanderbilt University Medical Center; US Department of Defense; Logistics Management Institute; Washington University School of Medicine; Bioqual, Inc.
Keywords: SARS-CoV-2, neutralizing human monoclonal antibodies, primates
Summary of Study: Neutralizing antibodies with extended half-life and lacking Fc-mediated effector functions are efficient for pre-exposure prophylaxis of SARS-CoV-2 infection in NHPs.
References: PMID: 35132398 / doi: 10.1016/j.medj.2022.01.004
Contact Info: Dan Barouch: [email protected]
URL: https://www.cell.com/med/fulltext/S2666-6340(22)00039-3?_returnURL=https%3A//li…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; Tongji Medical College of Huazhong University of Science & Technology
Keywords: SARS-CoV-2, infection, pathogenesis, virus variants, primates
Summary of Study: Delta variant of SARS-CoV-2 can effectively infect the Rhesus macaque.
References: PMID: 35279412 / doi: 10.1016/j.virs.2022.02.001
Contact Info: Zhiming Yuan: [email protected]; Chao Shan: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1995820X22000335?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; Tongji Medical College of Huazhong University of Science & Technology
Keywords: SARS-CoV-2, infection, pathogenesis, virus variants, primates
Summary of Study: Delta variant of SARS-CoV-2 can effectively infect the Rhesus macaque.
References: PMID: 35279412 / doi: 10.1016/j.virs.2022.02.001
Contact Info: Zhiming Yuan: [email protected]; Chao Shan: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1995820X22000335?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Illinois College of Medicine
Keywords: SARS-CoV-2, transcriptomic profiling, lung endothelial cells, primates
Summary of Study: The specific genes that distinguished immuneEC and devEC populations in the NHP lungs after SARS-CoV-2 infection were different from the endotoxemic mouse lung. This may reflect either species differences or different injury-specific responses (bacterial endotoxin vs. SARS-CoV-2).
References: PMID: 35511435 / doi: 10.1172/jci.insight.158079
Contact Info: Lianghui Zhang: [email protected]; Jalees Rehman: [email protected]
URL: https://insight.jci.org/articles/view/158079
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Illinois College of Medicine
Keywords: SARS-CoV-2, transcriptomic profiling, lung endothelial cells, primates
Summary of Study: The specific genes that distinguished immuneEC and devEC populations in the NHP lungs after SARS-CoV-2 infection were different from the endotoxemic mouse lung. This may reflect either species differences or different injury-specific responses (bacterial endotoxin vs. SARS-CoV-2).
References: PMID: 35511435 / doi: 10.1172/jci.insight.158079
Contact Info: Lianghui Zhang: [email protected]; Jalees Rehman: [email protected]
URL: https://insight.jci.org/articles/view/158079
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Inovio Pharmaceuticals; The Wistar Institute
Keywords: SARS-CoV-2, DNA vaccine, prime-boost vaccination, immune response, primates
Summary of Study: Illustrates the durability of immunity following vaccination with synthetic DNA vaccine encoding the wild-type Spike protein, INO-4800, and additionally supports the use of either INO-4800 or INO-4802 in prime-boost regimens.
References: PMID: 35428500 / doi: 10.1016/j.vaccine.2022.03.060
Contact Info: Kate Broderick: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22003681?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Inovio Pharmaceuticals; The Wistar Institute
Keywords: SARS-CoV-2, DNA vaccine, prime-boost vaccination, immune response, primates
Summary of Study: Illustrates the durability of immunity following vaccination with synthetic DNA vaccine encoding the wild-type Spike protein, INO-4800, and additionally supports the use of either INO-4800 or INO-4802 in prime-boost regimens.
References: PMID: 35428500 / doi: 10.1016/j.vaccine.2022.03.060
Contact Info: Kate Broderick: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22003681?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; University of California, San Diego; University of Cape Town, Observatory, South Africa
Keywords: SARS-CoV-2, mild infection, pathology, immune response, primates
Summary of Study: SARS-CoV-2 replication wanes in the lungs, as well as the nasal and oral mucosa, of rhesus macaques before antigen-specific effector T cells arrive at those sites, suggesting that innate immunity efficiently restricts viral replication during mild COVID-19.
References: PMID: 35271298 / doi: 10.1126/sciimmunol.abo0535
Contact Info: Daniel Barber: [email protected]
URL: https://www.science.org/doi/full/10.1126/sciimmunol.abo0535?rfr_dat=cr_pub%20%2…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; University of California, San Diego; University of Cape Town, Observatory, South Africa
Keywords: SARS-CoV-2, mild infection, pathology, immune response, primates
Summary of Study: SARS-CoV-2 replication wanes in the lungs, as well as the nasal and oral mucosa, of rhesus macaques before antigen-specific effector T cells arrive at those sites, suggesting that innate immunity efficiently restricts viral replication during mild COVID-19.
References: PMID: 35271298 / doi: 10.1126/sciimmunol.abo0535
Contact Info: Daniel Barber: [email protected]
URL: https://www.science.org/doi/full/10.1126/sciimmunol.abo0535?rfr_dat=cr_pub%20%2…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; China National Center for Bioinformation; Capital Medical University; Chinese Academy of Medical Sciences and Peking Union Medical College; Huazhong University of Science & Technology
Keywords: SARS-CoV-2, transcriptomic profiling, virus replication, primates
Summary of Study: This study provides the transcriptome profiling of various tissues from the living primate host post SARS-CoV-2 infection. It illustrates that wide-spread transcriptomic changes involving diverse functions exist in multi-organs; an elevated immune response in cerebral cortex was the prominent feature at the early stage of SARS-CoV-2 infection.
References: PMID: 35377064 / doi: 10.1007/s13238-022-00915-5
Contact Info: Ying Yang: [email protected]; Yun-Gui Yang: [email protected]; Chuan Qin: [email protected]; Wei-Min Tong: [email protected]
URL: https://link.springer.com/article/10.1007/s13238-022-00915-5
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; China National Center for Bioinformation; Capital Medical University; Chinese Academy of Medical Sciences and Peking Union Medical College; Huazhong University of Science & Technology
Keywords: SARS-CoV-2, transcriptomic profiling, virus replication, primates
Summary of Study: This study provides the transcriptome profiling of various tissues from the living primate host post SARS-CoV-2 infection. It illustrates that wide-spread transcriptomic changes involving diverse functions exist in multi-organs; an elevated immune response in cerebral cortex was the prominent feature at the early stage of SARS-CoV-2 infection.
References: PMID: 35377064 / doi: 10.1007/s13238-022-00915-5
Contact Info: Ying Yang: [email protected]; Yun-Gui Yang: [email protected]; Chuan Qin: [email protected]; Wei-Min Tong: [email protected]
URL: https://link.springer.com/article/10.1007/s13238-022-00915-5
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Institute de Biologie Structurale; Universite Paris-Saclay, Inserm, CEA; Amsterdam University Medical Centers; Institute Pasteur, Universite de Paris; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, vaccine candidate, synthetic spike (S) glycoprotein-coated lipid vesicles, immune response, primates
Summary of Study: Immunization of cynomolgus macaques with S coated onto lipid vesicles (S-LVs) induces high antibody titers with potent neutralizing activity against the vaccine strain, Alpha, Beta, and Gamma variants as well as T helper (Th)1 CD4+-biased T cell responses.
References: PMID: 35233549 / doi: 10.1016/j.xcrm.2022.100528
Contact Info: Winfried Weissenhorn: [email protected]; Roger Le Grand: [email protected]
URL: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00028-3?_retu…
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Institute de Biologie Structurale; Universite Paris-Saclay, Inserm, CEA; Amsterdam University Medical Centers; Institute Pasteur, Universite de Paris; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, vaccine candidate, synthetic spike (S) glycoprotein-coated lipid vesicles, immune response, primates
Summary of Study: Immunization of cynomolgus macaques with S coated onto lipid vesicles (S-LVs) induces high antibody titers with potent neutralizing activity against the vaccine strain, Alpha, Beta, and Gamma variants as well as T helper (Th)1 CD4+-biased T cell responses.
References: PMID: 35233549 / doi: 10.1016/j.xcrm.2022.100528
Contact Info: Winfried Weissenhorn: [email protected]; Roger Le Grand: [email protected]
URL: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00028-3?_retu…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Inovio Pharmaceuticals; The Wistar Institute
Keywords: SARS-CoV-2, DNA vaccine, prime-boost vaccination, immune response, primates
Summary of Study: Illustrates the durability of immunity following vaccination with synthetic DNA vaccine encoding the wild-type Spike protein, INO-4800, and additionally supports the use of either INO-4800 or INO-4802 in prime-boost regimens.
References: PMID: 35428500 / doi: 10.1016/j.vaccine.2022.03.060
Contact Info: Kate Broderick: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22003681?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Inovio Pharmaceuticals; The Wistar Institute
Keywords: SARS-CoV-2, DNA vaccine, prime-boost vaccination, immune response, primates
Summary of Study: Illustrates the durability of immunity following vaccination with synthetic DNA vaccine encoding the wild-type Spike protein, INO-4800, and additionally supports the use of either INO-4800 or INO-4802 in prime-boost regimens.
References: PMID: 35428500 / doi: 10.1016/j.vaccine.2022.03.060
Contact Info: Kate Broderick: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22003681?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: California National Primate Research Center; University of California, Davis; Vitalant Research Institute; University of Colorado School of Medicine; University of California, Irvine; University of California, San Francisco
Keywords: SARS-CoV-2, human convalescent plasma, inflammation, primates
Summary of Study: Administration of CCP had minimal effects on reducing virus replication in the respiratory tract, but it significantly reduced lung inflammation. These data, combined with the results of monoclonal antibody studies, emphasize the need to use products with high titers of neutralizing antibodies, and guide the future development of antibody-based therapies.
References: PMID: 35443018 / doi: 10.1371/journal.ppat.1009925
Contact Info: Koen Van Rompay: [email protected]; Michael Busch: [email protected]; Rachel Reader: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009925
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: California National Primate Research Center; University of California, Davis; Vitalant Research Institute; University of Colorado School of Medicine; University of California, Irvine; University of California, San Francisco
Keywords: SARS-CoV-2, human convalescent plasma, inflammation, primates
Summary of Study: Administration of CCP had minimal effects on reducing virus replication in the respiratory tract, but it significantly reduced lung inflammation. These data, combined with the results of monoclonal antibody studies, emphasize the need to use products with high titers of neutralizing antibodies, and guide the future development of antibody-based therapies.
References: PMID: 35443018 / doi: 10.1371/journal.ppat.1009925
Contact Info: Koen Van Rompay: [email protected]; Michael Busch: [email protected]; Rachel Reader: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009925
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Institute of Infectious Diseases, Tokyo; Kumamoto University; ID Pharma Co., Ltd.
Keywords: SARS-CoV-2, intranasal vaccine, non-S antigens, immune response, primates
Summary of Study: CD8+ T cell induction by intranasal vaccination with a vaccine expressing viral non-S antigens can result in NAb-independent control of SARS-CoV-2 infection.
References: PMID: 35233545 / doi: 10.1016/j.xcrm.2022.100520
Contact Info: Tetsuro Matano: [email protected]
URL: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00020-9?_retu…
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Institute of Infectious Diseases, Tokyo; Kumamoto University; ID Pharma Co., Ltd.
Keywords: SARS-CoV-2, intranasal vaccine, non-S antigens, immune response, primates
Summary of Study: CD8+ T cell induction by intranasal vaccination with a vaccine expressing viral non-S antigens can result in NAb-independent control of SARS-CoV-2 infection.
References: PMID: 35233545 / doi: 10.1016/j.xcrm.2022.100520
Contact Info: Tetsuro Matano: [email protected]
URL: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00020-9?_retu…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Tufts University Cummings School of Veterinary Medicine; Vaccine & Gene Therapy Institute/OHSU; University of Montreal; Oregon National Primate Research Center; Ragon Institute of MGH, MIT, and Harvard
Keywords: SARS-CoV-2, Ad26.COV2.S vaccine, transcriptional and proteomic profiling, primates
Summary of Study: Study showed that vaccination with Ad26.COV2.S protected hamsters and rhesus macaques challenged with SARS-CoV-2 from developing excessive proinflammatory responses mediated by IL-6 and IL-1, macrophages, and neutrophil activation.
References: PMID: 35395058 / doi: 10.1371/journal.ppat.1009990
Contact Info: Dan Barouch: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009990
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Tufts University Cummings School of Veterinary Medicine; Vaccine & Gene Therapy Institute/OHSU; University of Montreal; Oregon National Primate Research Center; Ragon Institute of MGH, MIT, and Harvard
Keywords: SARS-CoV-2, Ad26.COV2.S vaccine, transcriptional and proteomic profiling, primates
Summary of Study: Study showed that vaccination with Ad26.COV2.S protected hamsters and rhesus macaques challenged with SARS-CoV-2 from developing excessive proinflammatory responses mediated by IL-6 and IL-1, macrophages, and neutrophil activation.
References: PMID: 35395058 / doi: 10.1371/journal.ppat.1009990
Contact Info: Dan Barouch: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009990
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane School of Medicine
Keywords: SARS-CoV-2, monoclonal antibody prophylaxis, virus reproduction, primates
Summary of Study: High viral loads were observed in the intestinal mucosa of a rhesus macaque post challenge with SARS-CoV-2 after prophylactic administration of combination anti-spike antibody therapy. Intrahost evolution of virus was seen, with sequences changing in accordance with enhanced replication capacity, as well as site-specific differences potentially indicating preferential replication.
References: PMID: 35429402 / doi: 10.1093/infdis/jiac134
Contact Info: Chad Roy: [email protected]
URL: https://academic.oup.com/jid/article/226/9/1588/6569365?login=false
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane School of Medicine
Keywords: SARS-CoV-2, monoclonal antibody prophylaxis, virus reproduction, primates
Summary of Study: High viral loads were observed in the intestinal mucosa of a rhesus macaque post challenge with SARS-CoV-2 after prophylactic administration of combination anti-spike antibody therapy. Intrahost evolution of virus was seen, with sequences changing in accordance with enhanced replication capacity, as well as site-specific differences potentially indicating preferential replication.
References: PMID: 35429402 / doi: 10.1093/infdis/jiac134
Contact Info: Chad Roy: [email protected]
URL: https://academic.oup.com/jid/article/226/9/1588/6569365?login=false
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Bavarian Nordic GmbH; Biomedical Primate Research Centre; Aarhus University; University of Copenhagen; AdaptVac Aps
Keywords: SARS-CoV-2, capsid virus-like particle-based vaccine ABNCoV2, immunogenicity, primates
Summary of Study: ABNCoV2 induced strong and long-lasting neutralizing antibody responses and efficacy against SARS-CoV-2 in NHP.
References: PMID: 35479095 / doi: 10.3389/fimmu.2022.857440
Contact Info: Ariane Volkmann: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.857440/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Bavarian Nordic GmbH; Biomedical Primate Research Centre; Aarhus University; University of Copenhagen; AdaptVac Aps
Keywords: SARS-CoV-2, capsid virus-like particle-based vaccine ABNCoV2, immunogenicity, primates
Summary of Study: ABNCoV2 induced strong and long-lasting neutralizing antibody responses and efficacy against SARS-CoV-2 in NHP.
References: PMID: 35479095 / doi: 10.3389/fimmu.2022.857440
Contact Info: Ariane Volkmann: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.857440/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre; Department of Pathology, Amsterdam UMC; Utrecht University; Leiden University Medical Center; University of Twente
Keywords: SARS-CoV-2, neuropathology, immune response, primates
Summary of Study: Data highlight the potential of SARS-CoV-2 to cause pathology in the brain of macaques. A range of neurological abnormalities were observed, including hypermetabolic pituitary gland, alpha-synuclein inclusions, activated microglia in the brain parenchyma, and infiltrating T-cells.
References: PMID: 35458506 / doi: 10.3390/v14040776
Contact Info: Ernst Verschoor: [email protected]
URL: https://www.mdpi.com/1999-4915/14/4/776
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre; Department of Pathology, Amsterdam UMC; Utrecht University; Leiden University Medical Center; University of Twente
Keywords: SARS-CoV-2, neuropathology, immune response, primates
Summary of Study: Data highlight the potential of SARS-CoV-2 to cause pathology in the brain of macaques. A range of neurological abnormalities were observed, including hypermetabolic pituitary gland, alpha-synuclein inclusions, activated microglia in the brain parenchyma, and infiltrating T-cells.
References: PMID: 35458506 / doi: 10.3390/v14040776
Contact Info: Ernst Verschoor: [email protected]
URL: https://www.mdpi.com/1999-4915/14/4/776
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Sanofi R&D; Universite de Strasbourg; Equipe 3Bio
Keywords: SARS-CoV-2, mRNA vaccine, lipid nanoparticles, stability, mice, primates
Summary of Study: The thermostability of mRNA/LNP is improved by a novel imidazole modified lipid, DOG-IM4, in combination with standard helper lipids.
References: PMID: 35576809 / doi: 10.1016/j.biomaterials.2022.121570
Contact Info: Jean Haensler: [email protected];
URL: https://www.sciencedirect.com/science/article/pii/S0142961222002101?via%3Dihub=
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Sanofi R&D; Universite de Strasbourg; Equipe 3Bio
Keywords: SARS-CoV-2, mRNA vaccine, lipid nanoparticles, stability, mice, primates
Summary of Study: The thermostability of mRNA/LNP is improved by a novel imidazole modified lipid, DOG-IM4, in combination with standard helper lipids.
References: PMID: 35576809 / doi: 10.1016/j.biomaterials.2022.121570
Contact Info: Jean Haensler: [email protected];
URL: https://www.sciencedirect.com/science/article/pii/S0142961222002101?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Central Florida; Tulane National Primate Research Center
Keywords: SARS-CoV-2, pathology, heart, immune response, primates
Summary of Study: SARS-CoV-2 infection is characterized by an exaggerated inflammatory immune response in the heart, which possibly contributes to myocardial remodeling and subsequent fibrosis.
References: PMID: 35203260 / doi: 10.3390/cells11040611
Contact Info: Manish Kumar Gupta: [email protected]
URL: https://www.mdpi.com/2073-4409/11/4/611
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Central Florida; Tulane National Primate Research Center
Keywords: SARS-CoV-2, pathology, heart, immune response, primates
Summary of Study: SARS-CoV-2 infection is characterized by an exaggerated inflammatory immune response in the heart, which possibly contributes to myocardial remodeling and subsequent fibrosis.
References: PMID: 35203260 / doi: 10.3390/cells11040611
Contact Info: Manish Kumar Gupta: [email protected]
URL: https://www.mdpi.com/2073-4409/11/4/611
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Guangzhou Medical University; Macau University of Science and Technology; St. Januario Central Hospital Macau
Keywords: SARS-CoV-2, homologous or heterogenous vaccination boosters, virus variants, primates
Summary of Study: The Omicron BA.1 variant showed little sensitivity to all of the neutralizing antibodies evaluated in this study, adding to the emerging body of evidence that the resistance to neutralizing antibodies is conferred largely by the mutations in the RBD, since pseudovirus harboring additional spike protein mutations did not significantly change the resistance to neutralizing activity. A recombinant RBD protein vaccine may be a promising approach for future vaccine development.
References: PMID: 35592756 / doi: 10.1002/mco2.143
Contact Info: Kang Zhang: [email protected]; Gen Li: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095991/
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Guangzhou Medical University; Macau University of Science and Technology; St. Januario Central Hospital Macau
Keywords: SARS-CoV-2, homologous or heterogenous vaccination boosters, virus variants, primates
Summary of Study: The Omicron BA.1 variant showed little sensitivity to all of the neutralizing antibodies evaluated in this study, adding to the emerging body of evidence that the resistance to neutralizing antibodies is conferred largely by the mutations in the RBD, since pseudovirus harboring additional spike protein mutations did not significantly change the resistance to neutralizing activity. A recombinant RBD protein vaccine may be a promising approach for future vaccine development.
References: PMID: 35592756 / doi: 10.1002/mco2.143
Contact Info: Kang Zhang: [email protected]; Gen Li: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095991/
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Université Paris-Saclay; Assistance Publique-Hôpitaux de Paris; Obesity Center, Department of Digestive, Oncologic and Metabolic Surgery, Institut Mutualiste Montsouris, Paris
Keywords: SARS-CoV-2, fat tissue, diagnostics, immunity, primates
Summary of Study: Subcutaneous adipose tissue (SCAT) is selectively infected by SARS-CoV-2 although changes in the immune properties of adispose tissue are observed in both SCAT and visceral adipose tissue
References: PMID: 35661814 PMCID: PMC9166782 DOI: 10.1038/s42003-022-03503-9
Contact Info: Christine Bourgeois: [email protected]
URL: https://www.nature.com/articles/s42003-022-03503-9
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Université Paris-Saclay; Assistance Publique-Hôpitaux de Paris; Obesity Center, Department of Digestive, Oncologic and Metabolic Surgery, Institut Mutualiste Montsouris, Paris
Keywords: SARS-CoV-2, fat tissue, diagnostics, immunity, primates
Summary of Study: Subcutaneous adipose tissue (SCAT) is selectively infected by SARS-CoV-2 although changes in the immune properties of adispose tissue are observed in both SCAT and visceral adipose tissue
References: PMID: 35661814 PMCID: PMC9166782 DOI: 10.1038/s42003-022-03503-9
Contact Info: Christine Bourgeois: [email protected]
URL: https://www.nature.com/articles/s42003-022-03503-9
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: USAMRIID; Henry M. Jackson Foundation for the Advancement of Military Medicine; Walter Reed Army Institute of Research
Keywords: SARS-CoV-2, spike ferritin nanoparticle vaccine, immune response, primates
Summary of Study: Two adjuvants were compared (ALFQ and AIOH3): Robust humoral and cellular immunological responses were observed for vaccinated animals, with the ALFQ-adjuvanted group generating a significantly higher response compared ot the AIOH3 group. Vaccination with either adjuvant resulted in fewer clinical signs of disease compared to controls, including a significant reduction in lesions and virus replication in the lungs.
References: PMID: 35632473 / doi: 10.3390/vaccines10050717
Contact Info: Jeffrey Smith: [email protected]; Jay Hooper: [email protected]; Keersten Ricks: [email protected]; Hannah King: [email protected]; Kristina Peachman: [email protected]; Alexandra Jay: [email protected]
URL: https://www.mdpi.com/2076-393X/10/5/717
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: USAMRIID; Henry M. Jackson Foundation for the Advancement of Military Medicine; Walter Reed Army Institute of Research
Keywords: SARS-CoV-2, spike ferritin nanoparticle vaccine, immune response, primates
Summary of Study: Two adjuvants were compared (ALFQ and AIOH3): Robust humoral and cellular immunological responses were observed for vaccinated animals, with the ALFQ-adjuvanted group generating a significantly higher response compared ot the AIOH3 group. Vaccination with either adjuvant resulted in fewer clinical signs of disease compared to controls, including a significant reduction in lesions and virus replication in the lungs.
References: PMID: 35632473 / doi: 10.3390/vaccines10050717
Contact Info: Jeffrey Smith: [email protected]; Jay Hooper: [email protected]; Keersten Ricks: [email protected]; Hannah King: [email protected]; Kristina Peachman: [email protected]; Alexandra Jay: [email protected]
URL: https://www.mdpi.com/2076-393X/10/5/717
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, protocols, animal models, immunology, primates
Summary of Study: This book describes the different aspects of modelling the SARS-CoV-2 infection in NHPs along with the associated methods used in immunology.
References: PMID: 35554911 / doi. 10.1007/978-1-2111-0_15
Contact Info: Deepak Kaushal: [email protected]
URL: https://link.springer.com/protocol/10.1007/978-1-0716-2111-0_15
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, protocols, animal models, immunology, primates
Summary of Study: This book describes the different aspects of modelling the SARS-CoV-2 infection in NHPs along with the associated methods used in immunology.
References: PMID: 35554911 / doi. 10.1007/978-1-2111-0_15
Contact Info: Deepak Kaushal: [email protected]
URL: https://link.springer.com/protocol/10.1007/978-1-0716-2111-0_15
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Universite Paris-Saclay, INSERM, CEA; Life and Soft; IRCCS Ospedale San Raffaele; Institut Pasteur
Keywords: SARS-CoV-2, neonate animals, immune response, pathology, primates
Summary of Study: This pilot study demonstrates that neonatal NHPs are a relevant model for pediatric SARS-CoV-2 infection.
References: PMID: 35603150 / doi: 10.3389/fimmu.2022.855230
Contact Info: Nabila Seddiki: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.855230/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Universite Paris-Saclay, INSERM, CEA; Life and Soft; IRCCS Ospedale San Raffaele; Institut Pasteur
Keywords: SARS-CoV-2, neonate animals, immune response, pathology, primates
Summary of Study: This pilot study demonstrates that neonatal NHPs are a relevant model for pediatric SARS-CoV-2 infection.
References: PMID: 35603150 / doi: 10.3389/fimmu.2022.855230
Contact Info: Nabila Seddiki: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.855230/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Peking Union Medical College; National Center of Technology Innovation for Animal Model; Chinese Academy of Sciences; Capital Medical University
Keywords: SARS-CoV-2, inactivated vaccine, booster, immune response, virus variants, primates
Summary of Study: Animals administered with an indicated booster dose and subsequently challenged with Delta or Omicron variants showed markedly reduced viral loads and improved histopathological profiles compared to control animals, indicating that sequential immunization could protect primates against Omicron.
References: PMID: 35436986 / doi: 10.1038/s41392-022-00979-z
Contact Info: Chuan Qin: [email protected];
URL: https://www.nature.com/articles/s41392-022-00979-z
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Peking Union Medical College; National Center of Technology Innovation for Animal Model; Chinese Academy of Sciences; Capital Medical University
Keywords: SARS-CoV-2, inactivated vaccine, booster, immune response, virus variants, primates
Summary of Study: Animals administered with an indicated booster dose and subsequently challenged with Delta or Omicron variants showed markedly reduced viral loads and improved histopathological profiles compared to control animals, indicating that sequential immunization could protect primates against Omicron.
References: PMID: 35436986 / doi: 10.1038/s41392-022-00979-z
Contact Info: Chuan Qin: [email protected];
URL: https://www.nature.com/articles/s41392-022-00979-z
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Center for Genetic Engineering and Biotechnology, CIGB, Ave. 31 E/158 y 190, Havana 10600, Cuba
Keywords: SARS-CoV-2, chimeric antigen vaccine, immune response, mice, primates
Summary of Study: Fusion of SARS-CoV-2 receptor binding domain with the extracellular domain of human CD154 is a promising vaccine candidate
References: PMID: 35746505 PMCID: PMC9228316 DOI: 10.3390/vaccines10060897
Contact Info: Yamila Carpio and Mario Pablo Estrada: [email protected]; [email protected]
URL: https://www.mdpi.com/2076-393X/10/6/897
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Center for Genetic Engineering and Biotechnology, CIGB, Ave. 31 E/158 y 190, Havana 10600, Cuba
Keywords: SARS-CoV-2, chimeric antigen vaccine, immune response, mice, primates
Summary of Study: Fusion of SARS-CoV-2 receptor binding domain with the extracellular domain of human CD154 is a promising vaccine candidate
References: PMID: 35746505 PMCID: PMC9228316 DOI: 10.3390/vaccines10060897
Contact Info: Yamila Carpio and Mario Pablo Estrada: [email protected]; [email protected]
URL: https://www.mdpi.com/2076-393X/10/6/897
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Betuvax LLC; Lomonosov Moscow State University; Clinical Excellence Group LLC; I.I. Mechnikov North-Western State Medical University; PJSC Human Stem Cells Institute; Center of Genetics and Reproductive Medicine; Sechenov First Moscow State Medical University; Biotechnology Developments LLC; Ministry of Health of the Russian Federation
Keywords: SARS-CoV-2, subunit vaccine, “Betuvax-CoV-2”, preclinical studies, several animal species, primates
Summary of Study: A vaccine developed as a subunit that contains a recombinant receptor-binding domain fusion protein and virus-like nanoparticles demonstrates effective protection through COVID-19 neutralizing antibody production and conferring infection and lung damage protection.
References: PMID: 36016181 / doi: 10.3390/vaccines10081290
Contact Info: Anna Vakrusheva: [email protected]
URL: https://www.mdpi.com/2076-393X/10/8/1290
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Betuvax LLC; Lomonosov Moscow State University; Clinical Excellence Group LLC; I.I. Mechnikov North-Western State Medical University; PJSC Human Stem Cells Institute; Center of Genetics and Reproductive Medicine; Sechenov First Moscow State Medical University; Biotechnology Developments LLC; Ministry of Health of the Russian Federation
Keywords: SARS-CoV-2, subunit vaccine, “Betuvax-CoV-2”, preclinical studies, several animal species, primates
Summary of Study: A vaccine developed as a subunit that contains a recombinant receptor-binding domain fusion protein and virus-like nanoparticles demonstrates effective protection through COVID-19 neutralizing antibody production and conferring infection and lung damage protection.
References: PMID: 36016181 / doi: 10.3390/vaccines10081290
Contact Info: Anna Vakrusheva: [email protected]
URL: https://www.mdpi.com/2076-393X/10/8/1290
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Universite Paris-Saclay, Inserm, CEA; University of Amsterdam; Grousbeck Gene Therapy Center; Harvard Medical School; The Broad Institute of Harvard and MIT; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, computed X-ray tomography and [18F]-FDG positron emission tomography, pathology, primates
Summary of Study: CT, combined with [18F]-FDG PET imaging, to study SARS-CoV-2 infected NHPs, can produce strong and transposable readouts to monitor COVID-19 disease as well as the efficacy of future treatments and vaccine candidates.
References: PMID: 35313622 / doi: 10.1016/j.isci.2022.104101
Contact Info: Thibaut Naninck: [email protected]
URL: https://www.cell.com/iscience/fulltext/S2589-0042(22)00371-6?_returnURL=https%3…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Universite Paris-Saclay, Inserm, CEA; University of Amsterdam; Grousbeck Gene Therapy Center; Harvard Medical School; The Broad Institute of Harvard and MIT; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, computed X-ray tomography and [18F]-FDG positron emission tomography, pathology, primates
Summary of Study: CT, combined with [18F]-FDG PET imaging, to study SARS-CoV-2 infected NHPs, can produce strong and transposable readouts to monitor COVID-19 disease as well as the efficacy of future treatments and vaccine candidates.
References: PMID: 35313622 / doi: 10.1016/j.isci.2022.104101
Contact Info: Thibaut Naninck: [email protected]
URL: https://www.cell.com/iscience/fulltext/S2589-0042(22)00371-6?_returnURL=https%3…
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: Departments of Biochemistry and Pathology & Laboratory Medicine, Bhopal, India
Keywords: SARS-CoV-2, review, animal models, infection, pathology, primates
Summary of Study: Review of the immunological and clinical manifestations observed in various natural and genetically-modified animal models of numerous COVID-19 studies. The authors also summarize up-to-date laboratory findings on available and significant COVID-19 animal models, and put forth their perspective for the objective dependent usage of animal models.
References: PMID: 35757923 DOI: 10.1080/08830185.2022.2089666
Contact Info: Ashok Kumar: [email protected]
URL: https://www.tandfonline.com/doi/abs/10.1080/08830185.2022.2089666?journalCode=i…
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: Departments of Biochemistry and Pathology & Laboratory Medicine, Bhopal, India
Keywords: SARS-CoV-2, review, animal models, infection, pathology, primates
Summary of Study: Review of the immunological and clinical manifestations observed in various natural and genetically-modified animal models of numerous COVID-19 studies. The authors also summarize up-to-date laboratory findings on available and significant COVID-19 animal models, and put forth their perspective for the objective dependent usage of animal models.
References: PMID: 35757923 DOI: 10.1080/08830185.2022.2089666
Contact Info: Ashok Kumar: [email protected]
URL: https://www.tandfonline.com/doi/abs/10.1080/08830185.2022.2089666?journalCode=i…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; Tongji Medical College of Huazhong University of Science & Technology
Keywords: SARS-CoV-2, infection, pathogenesis, virus variants, primates
Summary of Study: Delta variant of SARS-CoV-2 can effectively infect the Rhesus macaque.
References: PMID: 35279412 / doi: 10.1016/j.virs.2022.02.001
Contact Info: Zhiming Yuan: [email protected]; Chao Shan: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1995820X22000335?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; Tongji Medical College of Huazhong University of Science & Technology
Keywords: SARS-CoV-2, infection, pathogenesis, virus variants, primates
Summary of Study: Delta variant of SARS-CoV-2 can effectively infect the Rhesus macaque.
References: PMID: 35279412 / doi: 10.1016/j.virs.2022.02.001
Contact Info: Zhiming Yuan: [email protected]; Chao Shan: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1995820X22000335?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: MIT; Harvard Medical School; University of Kansas; Tufts University; SpyBiotech Limited; Bioqual; Bill and Melinda Gates Medical Research Institute; Serum Institute of India; University of Oxford; Ragon Institute of MGH, MIT, and Harvard; Massachusetts Consortium on Pathogen Readiness
Keywords: SARS-CoV-2, receptor binding domain, HBsAg virus–like particles, immune response, primates
Summary of Study: A clinical-stage vaccine candidate comprising a SARS-CoV-2 receptor binding domain-hepatitis B surface antigen virus-like particle elicited protective immunity in cynomolgus macaques.
References: PMID: 35294244 / doi: 10.1126/sciadv.abl6015
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.abl6015?url_ver=Z39.88-2003&rfr_id=o…
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: MIT; Harvard Medical School; University of Kansas; Tufts University; SpyBiotech Limited; Bioqual; Bill and Melinda Gates Medical Research Institute; Serum Institute of India; University of Oxford; Ragon Institute of MGH, MIT, and Harvard; Massachusetts Consortium on Pathogen Readiness
Keywords: SARS-CoV-2, receptor binding domain, HBsAg virus–like particles, immune response, primates
Summary of Study: A clinical-stage vaccine candidate comprising a SARS-CoV-2 receptor binding domain-hepatitis B surface antigen virus-like particle elicited protective immunity in cynomolgus macaques.
References: PMID: 35294244 / doi: 10.1126/sciadv.abl6015
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.abl6015?url_ver=Z39.88-2003&rfr_id=o…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane School of Medicine
Keywords: SARS-CoV-2, monoclonal antibody prophylaxis, virus reproduction, primates
Summary of Study: High viral loads were observed in the intestinal mucosa of a rhesus macaque post challenge with SARS-CoV-2 after prophylactic administration of combination anti-spike antibody therapy. Intrahost evolution of virus was seen, with sequences changing in accordance with enhanced replication capacity, as well as site-specific differences potentially indicating preferential replication.
References: PMID: 35429402 / doi: 10.1093/infdis/jiac134
Contact Info: Chad Roy: [email protected]
URL: https://academic.oup.com/jid/article/226/9/1588/6569365?login=false
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane School of Medicine
Keywords: SARS-CoV-2, monoclonal antibody prophylaxis, virus reproduction, primates
Summary of Study: High viral loads were observed in the intestinal mucosa of a rhesus macaque post challenge with SARS-CoV-2 after prophylactic administration of combination anti-spike antibody therapy. Intrahost evolution of virus was seen, with sequences changing in accordance with enhanced replication capacity, as well as site-specific differences potentially indicating preferential replication.
References: PMID: 35429402 / doi: 10.1093/infdis/jiac134
Contact Info: Chad Roy: [email protected]
URL: https://academic.oup.com/jid/article/226/9/1588/6569365?login=false
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Institute of Biological Products; Chinese Academy of Medicine Sciences & Peking Union Medical College
Keywords: SARS-CoV-2, recombinant protein subunit vaccine and an inactivated vaccine, virus variants, primates
Summary of Study: Both vaccines evaluated in this study significantly reduced the viral load in the respiratory tract, alleviated pathological changes, and relieved lung inflammation in vaccinated macaques. The possible contribution of antibodies possessing neutralizing reactivity or cell-mediated cytotoxicity and immune memory to vaccine induced protection was also highlighted.
References: PMID: 35241645 / doi: 10.1038/s41392-022-00926-y
Contact Info: Junzhi Wang: [email protected]
URL: https://www.nature.com/articles/s41392-022-00926-y
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Institute of Biological Products; Chinese Academy of Medicine Sciences & Peking Union Medical College
Keywords: SARS-CoV-2, recombinant protein subunit vaccine and an inactivated vaccine, virus variants, primates
Summary of Study: Both vaccines evaluated in this study significantly reduced the viral load in the respiratory tract, alleviated pathological changes, and relieved lung inflammation in vaccinated macaques. The possible contribution of antibodies possessing neutralizing reactivity or cell-mediated cytotoxicity and immune memory to vaccine induced protection was also highlighted.
References: PMID: 35241645 / doi: 10.1038/s41392-022-00926-y
Contact Info: Junzhi Wang: [email protected]
URL: https://www.nature.com/articles/s41392-022-00926-y
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; University of California, San Diego; University of Cape Town, Observatory, South Africa
Keywords: SARS-CoV-2, mild infection, pathology, immune response, primates
Summary of Study: SARS-CoV-2 replication wanes in the lungs, as well as the nasal and oral mucosa, of rhesus macaques before antigen-specific effector T cells arrive at those sites, suggesting that innate immunity efficiently restricts viral replication during mild COVID-19.
References: PMID: 35271298 / doi: 10.1126/sciimmunol.abo0535
Contact Info: Daniel Barber: [email protected]
URL: https://www.science.org/doi/full/10.1126/sciimmunol.abo0535?rfr_dat=cr_pub%20%2…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; University of California, San Diego; University of Cape Town, Observatory, South Africa
Keywords: SARS-CoV-2, mild infection, pathology, immune response, primates
Summary of Study: SARS-CoV-2 replication wanes in the lungs, as well as the nasal and oral mucosa, of rhesus macaques before antigen-specific effector T cells arrive at those sites, suggesting that innate immunity efficiently restricts viral replication during mild COVID-19.
References: PMID: 35271298 / doi: 10.1126/sciimmunol.abo0535
Contact Info: Daniel Barber: [email protected]
URL: https://www.science.org/doi/full/10.1126/sciimmunol.abo0535?rfr_dat=cr_pub%20%2…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Institute of Zoonosis, and College of Veterinary Medicine, Jilin University; Chinese Academy of Medicine Sciences & Peking Union Medical College; Walvax Biotechnology Co., Ltd; Inner Mongolia University for Nationalities; Chinese Academy of Agricultural Sciences; Yuxi JOZO Biotechnology co., LTD; Tongji Medical College, Huazhong University of Science and Technology
Keywords: SARS-CoV-2, equine immunoglobulin, anti virus efficacy, histopathology, immune response, primates
Summary of Study: Therapeutic-grade equine immunoglobins are effective at improving the clinical symptoms of those hospitalized with SARS-CoV-2 and can be rapidly developed.
References: PMID: 35798694 / doi: 10.1038/s41392-022-01095-8
Contact Info: Zhongping Xie: [email protected]; Ningyi Jin: [email protected]; Mingyuan Liu: [email protected]
URL: https://www.nature.com/articles/s41392-022-01095-8
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Institute of Zoonosis, and College of Veterinary Medicine, Jilin University; Chinese Academy of Medicine Sciences & Peking Union Medical College; Walvax Biotechnology Co., Ltd; Inner Mongolia University for Nationalities; Chinese Academy of Agricultural Sciences; Yuxi JOZO Biotechnology co., LTD; Tongji Medical College, Huazhong University of Science and Technology
Keywords: SARS-CoV-2, equine immunoglobulin, anti virus efficacy, histopathology, immune response, primates
Summary of Study: Therapeutic-grade equine immunoglobins are effective at improving the clinical symptoms of those hospitalized with SARS-CoV-2 and can be rapidly developed.
References: PMID: 35798694 / doi: 10.1038/s41392-022-01095-8
Contact Info: Zhongping Xie: [email protected]; Ningyi Jin: [email protected]; Mingyuan Liu: [email protected]
URL: https://www.nature.com/articles/s41392-022-01095-8
Coronavirus Investigated: SARS-CoV-1, SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: The Scripps Research Institute; Massachusetts Institute of Technology; Alpha Genesis; University of California, San Diego; La Jolla Institute for Immunology; Howard Hughes Medical Institute; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University
Keywords: SARS-CoV-2, SARS-CoV-1, comparative studies, immune response, primates
Summary of Study: Using a two-shot protocol immunization with SARS-CoV-2 spike protein created strong serum receptor binding domain neutralizing antibody responses to both SARS-CoV-1 and SARS-CoV-2.
References: PMID: 35947674 / doi: 10.1126/scitranslmed.abl9605
Contact Info: Ian Wilson: [email protected]; Dennis Burton: [email protected]; Raiees Andrabi: [email protected]
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abl9605?rfr_dat=cr_pub%20…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: The Scripps Research Institute; Massachusetts Institute of Technology; Alpha Genesis; University of California, San Diego; La Jolla Institute for Immunology; Howard Hughes Medical Institute; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University
Keywords: SARS-CoV-2, SARS-CoV-1, comparative studies, immune response, primates
Summary of Study: Using a two-shot protocol immunization with SARS-CoV-2 spike protein created strong serum receptor binding domain neutralizing antibody responses to both SARS-CoV-1 and SARS-CoV-2.
References: PMID: 35947674 / doi: 10.1126/scitranslmed.abl9605
Contact Info: Ian Wilson: [email protected]; Dennis Burton: [email protected]; Raiees Andrabi: [email protected]
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abl9605?rfr_dat=cr_pub%20…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: MIT; Harvard Medical School; University of Kansas; Tufts University; SpyBiotech Limited; Bioqual; Bill and Melinda Gates Medical Research Institute; Serum Institute of India; University of Oxford; Ragon Institute of MGH, MIT, and Harvard; Massachusetts Consortium on Pathogen Readiness
Keywords: SARS-CoV-2, receptor binding domain, HBsAg virus–like particles, immune response, primates
Summary of Study: A clinical-stage vaccine candidate comprising a SARS-CoV-2 receptor binding domain-hepatitis B surface antigen virus-like particle elicited protective immunity in cynomolgus macaques.
References: PMID: 35294244 / doi: 10.1126/sciadv.abl6015
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.abl6015?url_ver=Z39.88-2003&rfr_id=o…
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: MIT; Harvard Medical School; University of Kansas; Tufts University; SpyBiotech Limited; Bioqual; Bill and Melinda Gates Medical Research Institute; Serum Institute of India; University of Oxford; Ragon Institute of MGH, MIT, and Harvard; Massachusetts Consortium on Pathogen Readiness
Keywords: SARS-CoV-2, receptor binding domain, HBsAg virus–like particles, immune response, primates
Summary of Study: A clinical-stage vaccine candidate comprising a SARS-CoV-2 receptor binding domain-hepatitis B surface antigen virus-like particle elicited protective immunity in cynomolgus macaques.
References: PMID: 35294244 / doi: 10.1126/sciadv.abl6015
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.abl6015?url_ver=Z39.88-2003&rfr_id=o…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Ragon Institute of MGH, MIT, and Harvard; University of Massachusetts; Bioqual
Keywords: SARS-CoV-2, adenovirus vector–based vaccine Ad26.COV2.S, immune response, primates
Summary of Study: Cytotoxic T-cells that are vaccine induced contribute to virus control, and when depleted, higher viral loads are seen in the respiratory tract.
References: PMID: 35943359 / doi: 10.1126/sciimmunol.abq7647
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/full/10.1126/sciimmunol.abq7647?rfr_dat=cr_pub%20%2…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Ragon Institute of MGH, MIT, and Harvard; University of Massachusetts; Bioqual
Keywords: SARS-CoV-2, adenovirus vector–based vaccine Ad26.COV2.S, immune response, primates
Summary of Study: Cytotoxic T-cells that are vaccine induced contribute to virus control, and when depleted, higher viral loads are seen in the respiratory tract.
References: PMID: 35943359 / doi: 10.1126/sciimmunol.abq7647
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/full/10.1126/sciimmunol.abq7647?rfr_dat=cr_pub%20%2…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre; Department of Pathology, Amsterdam UMC; Utrecht University; Leiden University Medical Center; University of Twente
Keywords: SARS-CoV-2, neuropathology, immune response, primates
Summary of Study: Data highlight the potential of SARS-CoV-2 to cause pathology in the brain of macaques. A range of neurological abnormalities were observed, including hypermetabolic pituitary gland, alpha-synuclein inclusions, activated microglia in the brain parenchyma, and infiltrating T-cells.
References: PMID: 35458506 / doi: 10.3390/v14040776
Contact Info: Ernst Verschoor: [email protected]
URL: https://www.mdpi.com/1999-4915/14/4/776
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre; Department of Pathology, Amsterdam UMC; Utrecht University; Leiden University Medical Center; University of Twente
Keywords: SARS-CoV-2, neuropathology, immune response, primates
Summary of Study: Data highlight the potential of SARS-CoV-2 to cause pathology in the brain of macaques. A range of neurological abnormalities were observed, including hypermetabolic pituitary gland, alpha-synuclein inclusions, activated microglia in the brain parenchyma, and infiltrating T-cells.
References: PMID: 35458506 / doi: 10.3390/v14040776
Contact Info: Ernst Verschoor: [email protected]
URL: https://www.mdpi.com/1999-4915/14/4/776
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Institutes for Food and Drug Control, Beijing; Guangzhou Laboratory; Kunming National High-level Biosafety Primate Research Center
Keywords: SARS-CoV-2, vaccine, chimpanzee adenovirus vector, immune response, mice, primates
Summary of Study: Using a chimpanzee adenovirus vectored vaccine expressing SARS-CoV2 spike in combination with an inactivated vaccine reduced lung injury risk while maintaining flexibility of the antibody regulation system.
References: PMID: 36059554 / doi: 10.3389/fimmu.2022.949248
Contact Info: Junzhi Wang: [email protected]; Zhenglun Liang: [email protected]; Miao Xu: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.949248/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: National Institutes for Food and Drug Control, Beijing; Guangzhou Laboratory; Kunming National High-level Biosafety Primate Research Center
Keywords: SARS-CoV-2, vaccine, chimpanzee adenovirus vector, immune response, mice, primates
Summary of Study: Using a chimpanzee adenovirus vectored vaccine expressing SARS-CoV2 spike in combination with an inactivated vaccine reduced lung injury risk while maintaining flexibility of the antibody regulation system.
References: PMID: 36059554 / doi: 10.3389/fimmu.2022.949248
Contact Info: Junzhi Wang: [email protected]; Zhenglun Liang: [email protected]; Miao Xu: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.949248/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; China National Center for Bioinformation; Capital Medical University; Chinese Academy of Medical Sciences and Peking Union Medical College; Huazhong University of Science & Technology
Keywords: SARS-CoV-2, transcriptomic profiling, virus replication, primates
Summary of Study: This study provides the transcriptome profiling of various tissues from the living primate host post SARS-CoV-2 infection. It illustrates that wide-spread transcriptomic changes involving diverse functions exist in multi-organs; an elevated immune response in cerebral cortex was the prominent feature at the early stage of SARS-CoV-2 infection.
References: PMID: 35377064 / doi: 10.1007/s13238-022-00915-5
Contact Info: Ying Yang: [email protected]; Yun-Gui Yang: [email protected]; Chuan Qin: [email protected]; Wei-Min Tong: [email protected]
URL: https://link.springer.com/article/10.1007/s13238-022-00915-5
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; China National Center for Bioinformation; Capital Medical University; Chinese Academy of Medical Sciences and Peking Union Medical College; Huazhong University of Science & Technology
Keywords: SARS-CoV-2, transcriptomic profiling, virus replication, primates
Summary of Study: This study provides the transcriptome profiling of various tissues from the living primate host post SARS-CoV-2 infection. It illustrates that wide-spread transcriptomic changes involving diverse functions exist in multi-organs; an elevated immune response in cerebral cortex was the prominent feature at the early stage of SARS-CoV-2 infection.
References: PMID: 35377064 / doi: 10.1007/s13238-022-00915-5
Contact Info: Ying Yang: [email protected]; Yun-Gui Yang: [email protected]; Chuan Qin: [email protected]; Wei-Min Tong: [email protected]
URL: https://link.springer.com/article/10.1007/s13238-022-00915-5
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Université Paris-Saclay; Université de Paris; Laboratoire de Pharmacocinétique et Toxicologie; Institut Pasteur; Centre International de Recherche en Infectiologie; Unité des Virus Emergents, Aix Marseille Univ; VirNext, Université Claude Bernard Lyon 1; University Hospital, Bordeaux & Inserm
Keywords: SARS-CoV-2, Zika, favipiravir, antiviral activity, primates
Summary of Study: A nucleoside analogue with activity against RNA viruses shows antiviral activity that reduces viral load and kinetics in Zika, but not COVID-19.
References: PMID: 36042198 / doi: 10.1038/s41467-022-32565-w
Contact Info: Roger Le Grand: [email protected]; Jeremie Guedj: [email protected]
URL: https://www.nature.com/articles/s41467-022-32565-w
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Université Paris-Saclay; Université de Paris; Laboratoire de Pharmacocinétique et Toxicologie; Institut Pasteur; Centre International de Recherche en Infectiologie; Unité des Virus Emergents, Aix Marseille Univ; VirNext, Université Claude Bernard Lyon 1; University Hospital, Bordeaux & Inserm
Keywords: SARS-CoV-2, Zika, favipiravir, antiviral activity, primates
Summary of Study: A nucleoside analogue with activity against RNA viruses shows antiviral activity that reduces viral load and kinetics in Zika, but not COVID-19.
References: PMID: 36042198 / doi: 10.1038/s41467-022-32565-w
Contact Info: Roger Le Grand: [email protected]; Jeremie Guedj: [email protected]
URL: https://www.nature.com/articles/s41467-022-32565-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Veterinary and Animal Sciences, Pakistan
Keywords: SARS-CoV-2, iodine complexes, treatment, primates
Summary of Study: Iodine complexes have antiviral activity and help to clear coronavirus from monkeys, and Renessans with iodine complexes and ascorbic acid may provide an additive option for treatment.
References: PMID: 36143459; doi: 10.3390/life12091424
Contact Info: Tahir Yaqub: [email protected]
URL: https://www.mdpi.com/2075-1729/12/9/1424
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Veterinary and Animal Sciences, Pakistan
Keywords: SARS-CoV-2, iodine complexes, treatment, primates
Summary of Study: Iodine complexes have antiviral activity and help to clear coronavirus from monkeys, and Renessans with iodine complexes and ascorbic acid may provide an additive option for treatment.
References: PMID: 36143459; doi: 10.3390/life12091424
Contact Info: Tahir Yaqub: [email protected]
URL: https://www.mdpi.com/2075-1729/12/9/1424
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences & Peking Union Medical College; Kunming No.1 High School; Kunming National High-level Biosafety Primate Research Center
Keywords: SARS-CoV-2, vaccines, repertoire diversities of B cells and T cells, whole-virus inactivated and S1 protein subunit vaccine, primates
Summary of Study: Comparison of B-cell and T-cell responses between a whole-virus inactivated vaccine and an S1 protein subunit vaccine.
References: PMID: 36070519 / doi: 10.1080/21645515.2022.2118477
Contact Info: Huiwen Zheng: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/21645515.2022.2118477
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences & Peking Union Medical College; Kunming No.1 High School; Kunming National High-level Biosafety Primate Research Center
Keywords: SARS-CoV-2, vaccines, repertoire diversities of B cells and T cells, whole-virus inactivated and S1 protein subunit vaccine, primates
Summary of Study: Comparison of B-cell and T-cell responses between a whole-virus inactivated vaccine and an S1 protein subunit vaccine.
References: PMID: 36070519 / doi: 10.1080/21645515.2022.2118477
Contact Info: Huiwen Zheng: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/21645515.2022.2118477
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: California National Primate Research Center; University of California, Davis
Keywords: SARS-CoV-2, surveillance, diagnostics, multi-antigen assays , RT-PCR, primates
Summary of Study: Colony management practices including restricted access, PPE, personnel vaccination and testing requirements have been adequate to prevent the spread of COVID-19 within the CNPRC NHP colony along with developing multi-antigen assays to survey the population.
References: PMID: 35794847 / doi: 10.1111/jmp.12604
Contact Info: JoAnn Yee: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1111/jmp.12604
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: California National Primate Research Center; University of California, Davis
Keywords: SARS-CoV-2, surveillance, diagnostics, multi-antigen assays , RT-PCR, primates
Summary of Study: Colony management practices including restricted access, PPE, personnel vaccination and testing requirements have been adequate to prevent the spread of COVID-19 within the CNPRC NHP colony along with developing multi-antigen assays to survey the population.
References: PMID: 35794847 / doi: 10.1111/jmp.12604
Contact Info: JoAnn Yee: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1111/jmp.12604
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: California National Primate Research Center; University of California, Davis; Vitalant Research Institute; University of Colorado School of Medicine; University of California, Irvine; University of California, San Francisco
Keywords: SARS-CoV-2, human convalescent plasma, inflammation, primates
Summary of Study: Administration of CCP had minimal effects on reducing virus replication in the respiratory tract, but it significantly reduced lung inflammation. These data, combined with the results of monoclonal antibody studies, emphasize the need to use products with high titers of neutralizing antibodies, and guide the future development of antibody-based therapies.
References: PMID: 35443018 / doi: 10.1371/journal.ppat.1009925
Contact Info: Koen Van Rompay: [email protected]; Michael Busch: [email protected]; Rachel Reader: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009925
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: California National Primate Research Center; University of California, Davis; Vitalant Research Institute; University of Colorado School of Medicine; University of California, Irvine; University of California, San Francisco
Keywords: SARS-CoV-2, human convalescent plasma, inflammation, primates
Summary of Study: Administration of CCP had minimal effects on reducing virus replication in the respiratory tract, but it significantly reduced lung inflammation. These data, combined with the results of monoclonal antibody studies, emphasize the need to use products with high titers of neutralizing antibodies, and guide the future development of antibody-based therapies.
References: PMID: 35443018 / doi: 10.1371/journal.ppat.1009925
Contact Info: Koen Van Rompay: [email protected]; Michael Busch: [email protected]; Rachel Reader: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009925
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital; National Kunming High-level Biosafety Primate Research Center; Nagasaki University; Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, self-assembled trimeric protein vaccine, virus variants, mice, primates
Summary of Study: A self-assembled trimeric protein made from linking a sequence from the Delta variant and a subunit in SARS-CoV-2 shows a strong immune response against Omicron variants.
References: PMID: 36115859 / doi: 10.1038/s41467-022-33209-9
Contact Info: Xiangrong Song: [email protected]; Shuaiyao Lu: [email protected]; Xiaozhong Peng: [email protected]; Guangwen Lu: [email protected]; Xiawei Wei: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482656/
NHP Species: multiple species
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital; National Kunming High-level Biosafety Primate Research Center; Nagasaki University; Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, self-assembled trimeric protein vaccine, virus variants, mice, primates
Summary of Study: A self-assembled trimeric protein made from linking a sequence from the Delta variant and a subunit in SARS-CoV-2 shows a strong immune response against Omicron variants.
References: PMID: 36115859 / doi: 10.1038/s41467-022-33209-9
Contact Info: Xiangrong Song: [email protected]; Shuaiyao Lu: [email protected]; Xiaozhong Peng: [email protected]; Guangwen Lu: [email protected]; Xiawei Wei: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482656/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; Yerkes National Primate Research Center; Emory School of Medicine; Bioqual; Modernal; Harvard T.H. Chan School of Public Health
Keywords: SARS-CoV-2, vaccination, mRNA-1273 or mRNA-Omicron boost, pathology, primates
Summary of Study: Boosting with homologous mRNA-1273 or mRNA-Omicron leads to comparable and significant increases in neutralizing antibody responses against all VOC, including Omicron.
References: PMID: 35447072 / doi: 10.1016/j.cell.2022.03.038
Contact Info: Daniel Douek: [email protected]; Robert Seder: [email protected]
URL: https://www.cell.com/cell/fulltext/S0092-8674(22)00388-9?_returnURL=https%3A//l…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; Yerkes National Primate Research Center; Emory School of Medicine; Bioqual; Modernal; Harvard T.H. Chan School of Public Health
Keywords: SARS-CoV-2, vaccination, mRNA-1273 or mRNA-Omicron boost, pathology, primates
Summary of Study: Boosting with homologous mRNA-1273 or mRNA-Omicron leads to comparable and significant increases in neutralizing antibody responses against all VOC, including Omicron.
References: PMID: 35447072 / doi: 10.1016/j.cell.2022.03.038
Contact Info: Daniel Douek: [email protected]; Robert Seder: [email protected]
URL: https://www.cell.com/cell/fulltext/S0092-8674(22)00388-9?_returnURL=https%3A//l…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Bordeaux; Université Paris-Saclay; Vaccine Research Institute Créteil; Inserm U955 Créteil; Baylor Scott and White Research Institute; Institut Pasteur Paris; CNRS UMR 3569; University of Amsterdam Amsterdam Infection & Immunity Institute Amsterdam; Hôpital Henri-Mondor Albert-Chenevier; CHU Bordeaux
Keywords: SARS-CoV-2, mathematical modelling, vaccine, viral dynamics, primates
Summary of Study: A model-based approach can identify mechanistic correlates of protection that vaccines provide against infection, such that inhibition of the receptor-binding domain to ACE2 represents a strong mechanism of protection.
References: PMID: 35801637 / doi: 10.7554/eLife.75427
Contact Info: Rodolphe Thiébaut: [email protected]
URL: https://elifesciences.org/articles/75427
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Bordeaux; Université Paris-Saclay; Vaccine Research Institute Créteil; Inserm U955 Créteil; Baylor Scott and White Research Institute; Institut Pasteur Paris; CNRS UMR 3569; University of Amsterdam Amsterdam Infection & Immunity Institute Amsterdam; Hôpital Henri-Mondor Albert-Chenevier; CHU Bordeaux
Keywords: SARS-CoV-2, mathematical modelling, vaccine, viral dynamics, primates
Summary of Study: A model-based approach can identify mechanistic correlates of protection that vaccines provide against infection, such that inhibition of the receptor-binding domain to ACE2 represents a strong mechanism of protection.
References: PMID: 35801637 / doi: 10.7554/eLife.75427
Contact Info: Rodolphe Thiébaut: [email protected]
URL: https://elifesciences.org/articles/75427
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Merck & Co., Inc., Rahway, NJ, USA; Certara, Princeton, NJ, USA
Keywords: SARS-CoV-2, vaccine, meta-analysis, preclinical and clinical data, immunogenicity, primates
Summary of Study: Development and application of a model-based meta-analysis (MBMA) approach integrating non-clinical and clinical immunogenicity and protection data.
References: doi: 10.1016/j.ebiom.2022.104264
Contact Info: Bhargava Kandala: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2352396422004467?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Merck & Co., Inc., Rahway, NJ, USA; Certara, Princeton, NJ, USA
Keywords: SARS-CoV-2, vaccine, meta-analysis, preclinical and clinical data, immunogenicity, primates
Summary of Study: Development and application of a model-based meta-analysis (MBMA) approach integrating non-clinical and clinical immunogenicity and protection data.
References: doi: 10.1016/j.ebiom.2022.104264
Contact Info: Bhargava Kandala: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2352396422004467?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: CAS Key Laboratory of Computational Biology; Shanghai Institute of Nutrition and Health; University of Chinese Academy of Sciences; Chinese Academy of Sciences; Max Planck Institute of Psychiatry, Proteomics and Biomarkers
Keywords: SARS-CoV-2, circadian gene networks, transcriptome, primates
Summary of Study: Many mammalian genes are controlled by a central clock under circadian control, resulting in a rhythmic expression of genes involved in homeostasis. SARS-CoV-2 related genes are also rhythmically expressed, suggesting close interactions with circadian regulators.
References: PMID: 35906476 / doi: 10.1038/s42003-022-03722-0
Contact Info: Guang-Zhong Wang: [email protected]
URL: https://www.nature.com/articles/s42003-022-03722-0
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: CAS Key Laboratory of Computational Biology; Shanghai Institute of Nutrition and Health; University of Chinese Academy of Sciences; Chinese Academy of Sciences; Max Planck Institute of Psychiatry, Proteomics and Biomarkers
Keywords: SARS-CoV-2, circadian gene networks, transcriptome, primates
Summary of Study: Many mammalian genes are controlled by a central clock under circadian control, resulting in a rhythmic expression of genes involved in homeostasis. SARS-CoV-2 related genes are also rhythmically expressed, suggesting close interactions with circadian regulators.
References: PMID: 35906476 / doi: 10.1038/s42003-022-03722-0
Contact Info: Guang-Zhong Wang: [email protected]
URL: https://www.nature.com/articles/s42003-022-03722-0