Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Science, Trinomab Biotech Co.
Keywords: SARS-CoV-2, ferritin nanoparticles, receptor-binding domain of SARS-CoV-2, immune response, primates
Summary of Study: Self-assembling nanoparticle vaccines displaying the RBD of SARS-CoV-2 were prepared, and the vaccine candidate elicited robust humoral and T cell responses and protected the rhesus monkeys from infection with short-term shedding and only minor pathological damage.
References: PMID: 33951913 / doi: 10.1021/acs.bioconjchem.1c00208
Contact Info: Longding Liu: [email protected]; Qihan Li: [email protected]; Zhanlong He: [email protected]
URL: https://pubs.acs.org/doi/10.1021/acs.bioconjchem.1c00208
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Science, Trinomab Biotech Co.
Keywords: SARS-CoV-2, ferritin nanoparticles, receptor-binding domain of SARS-CoV-2, immune response, primates
Summary of Study: Self-assembling nanoparticle vaccines displaying the RBD of SARS-CoV-2 were prepared, and the vaccine candidate elicited robust humoral and T cell responses and protected the rhesus monkeys from infection with short-term shedding and only minor pathological damage.
References: PMID: 33951913 / doi: 10.1021/acs.bioconjchem.1c00208
Contact Info: Longding Liu: [email protected]; Qihan Li: [email protected]; Zhanlong He: [email protected]
URL: https://pubs.acs.org/doi/10.1021/acs.bioconjchem.1c00208
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Clover Biopharmaceuticals, Kunming Institute of Zoology
Keywords: SARS-CoV-2, S-Trimer, subunit vaccine candidate, immunogenicity, efficacy, primates
Summary of Study: Rhesus macaques immunized with adjuvanted S-Trimer were protected from SARS-CoV-2 challenge. Trimer-Tag may be an important platform technology for scalable production and rapid development of safe and effective subunit vaccines against current and future emerging RNA viruses.
References: PMID: 33649323 / doi: 10.1038/s41467-021-21634-1
Contact Info: Peng Liang: [email protected]
URL: https://www.nature.com/articles/s41467-021-21634-1
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Clover Biopharmaceuticals, Kunming Institute of Zoology
Keywords: SARS-CoV-2, S-Trimer, subunit vaccine candidate, immunogenicity, efficacy, primates
Summary of Study: Rhesus macaques immunized with adjuvanted S-Trimer were protected from SARS-CoV-2 challenge. Trimer-Tag may be an important platform technology for scalable production and rapid development of safe and effective subunit vaccines against current and future emerging RNA viruses.
References: PMID: 33649323 / doi: 10.1038/s41467-021-21634-1
Contact Info: Peng Liang: [email protected]
URL: https://www.nature.com/articles/s41467-021-21634-1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: California National Primate Research Center, UC Davis
Keywords: SARS-CoV-2, CD4 T follicular helper (Tfh) cells, primates
Summary of Study: SARC-CoV-2 infection in rhesus macaques, either infused with convalescent plasma, normal plasma, or receiving no infusion showed induction of germinal center (GC) responses.
References: PMID: 33483492 / doi: 10.1038/s41467-020-20642-x
Contact Info: Koen Van Rompay: [email protected]; Smita Iyer: [email protected]
URL: https://www.nature.com/articles/s41467-020-20642-x
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: California National Primate Research Center, UC Davis
Keywords: SARS-CoV-2, CD4 T follicular helper (Tfh) cells, primates
Summary of Study: SARC-CoV-2 infection in rhesus macaques, either infused with convalescent plasma, normal plasma, or receiving no infusion showed induction of germinal center (GC) responses.
References: PMID: 33483492 / doi: 10.1038/s41467-020-20642-x
Contact Info: Koen Van Rompay: [email protected]; Smita Iyer: [email protected]
URL: https://www.nature.com/articles/s41467-020-20642-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: The Wistar Institute; Inovio Pharmaceuticals; Bioqual
Keywords: SARS-CoV-2, DNA vaccine, immunogenicity, immune response, adaptive immune response, primates
Summary of Study: INO-4800, an intradermal-delivered SARS-CoV-2 spike DNA vaccine, induced both humoral and cellular arms of the adaptive immune system.
References: PMID: 34604818 / doi: 10.1016/j.xcrm.2021.100420
Contact Info: Kate Broderick: [email protected]; David Weiner: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379121002822?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: The Wistar Institute; Inovio Pharmaceuticals; Bioqual
Keywords: SARS-CoV-2, DNA vaccine, immunogenicity, immune response, adaptive immune response, primates
Summary of Study: INO-4800, an intradermal-delivered SARS-CoV-2 spike DNA vaccine, induced both humoral and cellular arms of the adaptive immune system.
References: PMID: 34604818 / doi: 10.1016/j.xcrm.2021.100420
Contact Info: Kate Broderick: [email protected]; David Weiner: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379121002822?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Beth Israel Deaconess Medical Center, MIT, Harvard
Keywords: SARS-CoV-2, DNA- and Ad26-based vaccines, serum profiles, primates
Summary of Study: Data highlight the similarities between infection and vaccine induced humoral immunity for SARS-Cov-2 and cross-reactivity of these responses to other CoVs.
References: PMID: 33692201 / doi: 10.1128/JVI.00117-21
Contact Info: Dan Barouch: [email protected]
URL: https://journals.asm.org/doi/10.1128/JVI.00117-21?url_ver=Z39.88-2003&rfr_id=or…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Beth Israel Deaconess Medical Center, MIT, Harvard
Keywords: SARS-CoV-2, DNA- and Ad26-based vaccines, serum profiles, primates
Summary of Study: Data highlight the similarities between infection and vaccine induced humoral immunity for SARS-Cov-2 and cross-reactivity of these responses to other CoVs.
References: PMID: 33692201 / doi: 10.1128/JVI.00117-21
Contact Info: Dan Barouch: [email protected]
URL: https://journals.asm.org/doi/10.1128/JVI.00117-21?url_ver=Z39.88-2003&rfr_id=or…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Univ. of Pennsylvania Perelman School of Medicine
Keywords: SARS-CoV-2, D614G Spike Mutation, Vaccinated and immune sera, neutralization, primates
Summary of Study: Vaccinated NHPs using the nucleoside-modified mRNA-LNP vaccine platform encoding four differentSARS-CoV-2 spike immunogens generate antibody responses that not only recognize the G614 mutation that has taken over the pandemic, but also have stronger titers of neutralization to this virus variant.
References: PMID: 33306985/doi: 10.1016/j.chom.2020.11.012
Contact Info: Drew Weissman (no contact information)
URL: https://www.sciencedirect.com/science/article/pii/S193131282030634X?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Univ. of Pennsylvania Perelman School of Medicine
Keywords: SARS-CoV-2, D614G Spike Mutation, Vaccinated and immune sera, neutralization, primates
Summary of Study: Vaccinated NHPs using the nucleoside-modified mRNA-LNP vaccine platform encoding four differentSARS-CoV-2 spike immunogens generate antibody responses that not only recognize the G614 mutation that has taken over the pandemic, but also have stronger titers of neutralization to this virus variant.
References: PMID: 33306985/doi: 10.1016/j.chom.2020.11.012
Contact Info: Drew Weissman (no contact information)
URL: https://www.sciencedirect.com/science/article/pii/S193131282030634X?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Shiga University of Medical Science, Otsu, Japan
Keywords: SARS-CoV-2, severe acute respiratory syndrome, immune response, primates
Summary of Study: Cynomolgus macaques infected with SARS-CoV-2 showed body temperature rises and X-ray radiographic pneumonia without life-threatening clinical signs of disease. Because of similar symptoms to approximately 80% of patients, cynomolgus macaques are appropriate to extrapolate the efficacy of vaccines and antiviral drugs for humans.
References: PMID: 33412411/doi: 10.1016/j.virol.2020.12.013
Contact Info: Yasushi Itoh (no contact information)
URL: https://www.sciencedirect.com/science/article/pii/S0042682220302609?via%3Dihub=
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Shiga University of Medical Science, Otsu, Japan
Keywords: SARS-CoV-2, severe acute respiratory syndrome, immune response, primates
Summary of Study: Cynomolgus macaques infected with SARS-CoV-2 showed body temperature rises and X-ray radiographic pneumonia without life-threatening clinical signs of disease. Because of similar symptoms to approximately 80% of patients, cynomolgus macaques are appropriate to extrapolate the efficacy of vaccines and antiviral drugs for humans.
References: PMID: 33412411/doi: 10.1016/j.virol.2020.12.013
Contact Info: Yasushi Itoh (no contact information)
URL: https://www.sciencedirect.com/science/article/pii/S0042682220302609?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Universite de Paris, Institut Pasteur and others
Keywords: SARS-CoV-2, mathematical model, viral dynamics, immune response, viral clearance, primates
Summary of Study: Results provide estimates of SARS-CoV-2 viral kinetic parameters in an experimental model of mild infection and they provide means to assess the efficacy of future antiviral treatments.
References: PMID: 33730053 / doi: 10.1371/journal.pcbi.1008785
Contact Info: Antonio Goncalves: [email protected]
URL: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008785
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Universite de Paris, Institut Pasteur and others
Keywords: SARS-CoV-2, mathematical model, viral dynamics, immune response, viral clearance, primates
Summary of Study: Results provide estimates of SARS-CoV-2 viral kinetic parameters in an experimental model of mild infection and they provide means to assess the efficacy of future antiviral treatments.
References: PMID: 33730053 / doi: 10.1371/journal.pcbi.1008785
Contact Info: Antonio Goncalves: [email protected]
URL: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008785
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIAID; University of Colorado School of Medicine
Keywords: SARS-CoV-2, role of T cells in recovery, immune response, primates
Summary of Study: Results suggest that T cells are not critical for recovery from acute SARS-CoV-2 infections in the rhesus macaque model (which develop only mild COVID-19, similar to most humans), pointing toward B cell responses and antibodies as the essential mediators of protection from re-exposure.
References: PMID: 34311582 / doi: 10.1128/mBio.01503-21
Contact Info: Kim Hasenkrug: [email protected]
URL: https://journals.asm.org/doi/10.1128/mBio.01503-21
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIAID; University of Colorado School of Medicine
Keywords: SARS-CoV-2, role of T cells in recovery, immune response, primates
Summary of Study: Results suggest that T cells are not critical for recovery from acute SARS-CoV-2 infections in the rhesus macaque model (which develop only mild COVID-19, similar to most humans), pointing toward B cell responses and antibodies as the essential mediators of protection from re-exposure.
References: PMID: 34311582 / doi: 10.1128/mBio.01503-21
Contact Info: Kim Hasenkrug: [email protected]
URL: https://journals.asm.org/doi/10.1128/mBio.01503-21
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Indian Veterinary Research Institute and others
Keywords: SARS-CoV-2, domestic and wild animal species, public health
Summary of Study: This review analyzes the current evidence of SARS-CoV-2 natural infection in domestic and wild animal species and their possible implications on public health.
References: PMID: 33892621 / doi: 10.1080/01652176/2021.1921311
Contact Info: Khan Sharun: [email protected]; Kuldeep Dhama: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128218/pdf/TVEQ_41_1921311.pdf
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Indian Veterinary Research Institute and others
Keywords: SARS-CoV-2, domestic and wild animal species, public health
Summary of Study: This review analyzes the current evidence of SARS-CoV-2 natural infection in domestic and wild animal species and their possible implications on public health.
References: PMID: 33892621 / doi: 10.1080/01652176/2021.1921311
Contact Info: Khan Sharun: [email protected]; Kuldeep Dhama: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128218/pdf/TVEQ_41_1921311.pdf
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences, Nanjing University
Keywords: SARS-CoV-2, pathology, primates
Summary of Study: SARS-CoV-2-infected northern pig-tailed macaques could be considered as a critically ill animal model in COVID-19 research.
References: PMID: 33998182 / doi: 10.24272/j.issn.2095-8137.2020.334
Contact Info: Yong-Tang Zheng: [email protected]
URL: http://www.zoores.ac.cn/article/doi/10.24272/j.issn.2095-8137.2020.334
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences, Nanjing University
Keywords: SARS-CoV-2, pathology, primates
Summary of Study: SARS-CoV-2-infected northern pig-tailed macaques could be considered as a critically ill animal model in COVID-19 research.
References: PMID: 33998182 / doi: 10.24272/j.issn.2095-8137.2020.334
Contact Info: Yong-Tang Zheng: [email protected]
URL: http://www.zoores.ac.cn/article/doi/10.24272/j.issn.2095-8137.2020.334
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Karolinska Institutet; University of Cape Town
Keywords: SARS-CoV-2, virus genomic variants, antigenic sin, boost, passive immunization, mice, primates
Summary of Study: A single dose of adjuvanted beta variant receptor binding domain (RBD) protein broadens neutralizing antibody responses to heterologous VOCs.
References: PMID: 34723224 / doi: 10.1016/j.xcrm.2021.100450
Contact Info: Daniel Sheward: [email protected]; Gunilla Karlsson Hedestam: [email protected]; Ben Murrell: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379121003189?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Karolinska Institutet; University of Cape Town
Keywords: SARS-CoV-2, virus genomic variants, antigenic sin, boost, passive immunization, mice, primates
Summary of Study: A single dose of adjuvanted beta variant receptor binding domain (RBD) protein broadens neutralizing antibody responses to heterologous VOCs.
References: PMID: 34723224 / doi: 10.1016/j.xcrm.2021.100450
Contact Info: Daniel Sheward: [email protected]; Gunilla Karlsson Hedestam: [email protected]; Ben Murrell: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379121003189?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Karolinska Institute, University of Cape Town
Keywords: SARS-CoV-2, spike protein subunit vaccine, mice and primates, immune response
Summary of Study: Adjuvanted protein immunization with soluble SARS-CoV-2 Spike trimers, stabilized in prefusion conformation, results in potent antibody responses in mice and rhesus macaques, with neutralizing antibody titers exceeding those typically measured in SARS-CoV-2 seropositive humans by more than one order of magnitude.
References: PMID: 33842900 / doi: 10.1016/j.xcrm.2021.10052
Contact Info: Ben Murrell: [email protected]; Daniel Sheward: [email protected], Gunilla Karlsson Hedestam: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379121000689?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Karolinska Institute, University of Cape Town
Keywords: SARS-CoV-2, spike protein subunit vaccine, mice and primates, immune response
Summary of Study: Adjuvanted protein immunization with soluble SARS-CoV-2 Spike trimers, stabilized in prefusion conformation, results in potent antibody responses in mice and rhesus macaques, with neutralizing antibody titers exceeding those typically measured in SARS-CoV-2 seropositive humans by more than one order of magnitude.
References: PMID: 33842900 / doi: 10.1016/j.xcrm.2021.10052
Contact Info: Ben Murrell: [email protected]; Daniel Sheward: [email protected], Gunilla Karlsson Hedestam: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379121000689?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane NPRC, North Carolina State University
Keywords: SARS-CoV-2, portable, ultrasensitive saliva-based virus assay, primates
Summary of Study: CRISPR-FDS determined that mean SARS-Cov-2 RNA levels were 3.6 fold to 124-fold higher, and more stable, in oropharyngeal versus nasal swab samples from nonhuman primates at all time points after infection, suggesting that saliva may represent a more robust diagnostic sample than nasal swabs both early and later in infection.
References: PMID: 33310733 / doi: 10.1126/sciadv.abe3703
Contact Info: Tony Hu: [email protected]
URL: https://advances.sciencemag.org/content/7/2/eabe3703
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane NPRC, North Carolina State University
Keywords: SARS-CoV-2, portable, ultrasensitive saliva-based virus assay, primates
Summary of Study: CRISPR-FDS determined that mean SARS-Cov-2 RNA levels were 3.6 fold to 124-fold higher, and more stable, in oropharyngeal versus nasal swab samples from nonhuman primates at all time points after infection, suggesting that saliva may represent a more robust diagnostic sample than nasal swabs both early and later in infection.
References: PMID: 33310733 / doi: 10.1126/sciadv.abe3703
Contact Info: Tony Hu: [email protected]
URL: https://advances.sciencemag.org/content/7/2/eabe3703
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Dalhousie University; University of Calgary
Keywords: SARS-CoV-2, anthropozoonosis, virus transmission between the animal species, primates
Summary of Study: While the risk of transmission of SARS-CoV-2 via wastewater is low, tracing of viral RNA in wastewater does provide a unique testing approach to help protect NHPs at zoos and wildlife sanctuaries.
References: PMID: 34662463 / doi: 10.1002/ajp.23340
Contact Info: Graham Dellaire: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/ajp.23340
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Dalhousie University; University of Calgary
Keywords: SARS-CoV-2, anthropozoonosis, virus transmission between the animal species, primates
Summary of Study: While the risk of transmission of SARS-CoV-2 via wastewater is low, tracing of viral RNA in wastewater does provide a unique testing approach to help protect NHPs at zoos and wildlife sanctuaries.
References: PMID: 34662463 / doi: 10.1002/ajp.23340
Contact Info: Graham Dellaire: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/ajp.23340
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Melbourne, Monash University
Keywords: SARS-CoV-2, prime-boost protein subunit vaccine, mice and primates
Summary of Study: Both S and RBD vaccines are comparably immunogenic and produced strong serological neutralizing responses in pig-tailed macaques. Overall, immunization with recombinant S immunogens reliably elicits potentially protective humoral immunity at levels in excess of those observed in convalescent human, confirming recombinant S proteins as promising vaccine candidates.
References: PMID: 33658497 / doi: 10.1038/s41467-021-21665-8
Contact Info: Stephen Kent: [email protected]
URL: https://www.nature.com/articles/s41467-021-21665-8
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Melbourne, Monash University
Keywords: SARS-CoV-2, prime-boost protein subunit vaccine, mice and primates
Summary of Study: Both S and RBD vaccines are comparably immunogenic and produced strong serological neutralizing responses in pig-tailed macaques. Overall, immunization with recombinant S immunogens reliably elicits potentially protective humoral immunity at levels in excess of those observed in convalescent human, confirming recombinant S proteins as promising vaccine candidates.
References: PMID: 33658497 / doi: 10.1038/s41467-021-21665-8
Contact Info: Stephen Kent: [email protected]
URL: https://www.nature.com/articles/s41467-021-21665-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Texas Medical Branch, Pfizer
Keywords: SARS-CoV-2, vaccine-elicited immunity, virus variant, primates
Summary of Study: The D614G mutation modestly reduced SARS-CoV-2 neutralization by BNT162b2 vaccine-elicited mouse, rhesus, and human sera, concurring with the 95% vaccine efficacy observed in clinical trial.
References: PMID: 33767200 / doi: 10.1038/s41541-021-00313-8
Contact Info: Philip Dormitzer: philip,[email protected]
URL: https://www.nature.com/articles/s41541-021-00313-8
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Texas Medical Branch, Pfizer
Keywords: SARS-CoV-2, vaccine-elicited immunity, virus variant, primates
Summary of Study: The D614G mutation modestly reduced SARS-CoV-2 neutralization by BNT162b2 vaccine-elicited mouse, rhesus, and human sera, concurring with the 95% vaccine efficacy observed in clinical trial.
References: PMID: 33767200 / doi: 10.1038/s41541-021-00313-8
Contact Info: Philip Dormitzer: philip,[email protected]
URL: https://www.nature.com/articles/s41541-021-00313-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Iowa; University of Florida
Keywords: SARS-CoV-2, meta analysis, airway mucus, mucin glycoproteins, inflammation, primates
Summary of Study: Ferrets, nonhuman primates, and cats may have advantages over other models to investigate mucus in COVID-19.
References: PMID: 34794359 / doi: 10.1177/03009858211058837
Contact Info: not available
URL: https://journals.sagepub.com/doi/10.1177/03009858211058837?url_ver=Z39.88-2003&…
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Iowa; University of Florida
Keywords: SARS-CoV-2, meta analysis, airway mucus, mucin glycoproteins, inflammation, primates
Summary of Study: Ferrets, nonhuman primates, and cats may have advantages over other models to investigate mucus in COVID-19.
References: PMID: 34794359 / doi: 10.1177/03009858211058837
Contact Info: not available
URL: https://journals.sagepub.com/doi/10.1177/03009858211058837?url_ver=Z39.88-2003&…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Perelman School of Medicine (UPenn)
Keywords: SARS-CoV-2, clinical and pathologic consequences, ACE2 decoy protein, primates
Summary of Study: The ACE2 decoy (soluble forms of angiotensin-converting enzyme 2) gene therapy approach could be effectively deployed to vulnerable populations in the COVID-19 pandemic and potentially to broader populations at the outset of future coronavirus pandemics.
References: PMID: 34265018 / doi: 10.1371/journal.ppat.1009544
Contact Info: James Wilson: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009544
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Perelman School of Medicine (UPenn)
Keywords: SARS-CoV-2, clinical and pathologic consequences, ACE2 decoy protein, primates
Summary of Study: The ACE2 decoy (soluble forms of angiotensin-converting enzyme 2) gene therapy approach could be effectively deployed to vulnerable populations in the COVID-19 pandemic and potentially to broader populations at the outset of future coronavirus pandemics.
References: PMID: 34265018 / doi: 10.1371/journal.ppat.1009544
Contact Info: James Wilson: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009544
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Copycat Sciences; Sporos Bioventures
Keywords: SARS-CoV-2, redelivery, analysis of the preclinical data and clinical efficacy, primates
Summary of Study: The gap between the strong preclinical data with remdesivir (RDV) across many virus models and its questionable clinical activity suggests that assumptions are being made at the preclinical level that do not reflect the conditions observed in patients.
References: PMID: 34252308 / doi: 10.1128/AAC.01117-21
Contact Info: Victoria Yan: [email protected]
URL: https://journals.asm.org/doi/10.1128/AAC.01117-21?url_ver=Z39.88-2003&rfr_id=or…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Copycat Sciences; Sporos Bioventures
Keywords: SARS-CoV-2, redelivery, analysis of the preclinical data and clinical efficacy, primates
Summary of Study: The gap between the strong preclinical data with remdesivir (RDV) across many virus models and its questionable clinical activity suggests that assumptions are being made at the preclinical level that do not reflect the conditions observed in patients.
References: PMID: 34252308 / doi: 10.1128/AAC.01117-21
Contact Info: Victoria Yan: [email protected]
URL: https://journals.asm.org/doi/10.1128/AAC.01117-21?url_ver=Z39.88-2003&rfr_id=or…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Emory University School of Medicine
Keywords: SARS-CoV-2, several animal species, anti-viral therapeutic, vaccine development, primates
Summary of Study: Summarizing key features, strengths and weaknesses of animal models for SARS-CoV-2, focusing on their application in anti-viral therapeutic and vaccine development.
References: PMID: 33906125 / doi: 10.1016/j.coviro.2021.03.009
Contact Info: Anice Lowen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1879625721000316?via%3Dihub=
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Emory University School of Medicine
Keywords: SARS-CoV-2, several animal species, anti-viral therapeutic, vaccine development, primates
Summary of Study: Summarizing key features, strengths and weaknesses of animal models for SARS-CoV-2, focusing on their application in anti-viral therapeutic and vaccine development.
References: PMID: 33906125 / doi: 10.1016/j.coviro.2021.03.009
Contact Info: Anice Lowen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1879625721000316?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, resources, pathology, primates
Summary of Study: Because the SARS-CoV-2 pandemic has significantly increased the demand for rhesus macaques biomedical researchers will need to consider alternative NHP models for COVID-19 research and for other biomedical research studies. The authors suggest alternatives.
References: PMID: 33785923 / doi: 10.1038/s41684-021-00755-6
Contact Info: Michael Chang: chang,[email protected]
URL: https://www.nature.com/articles/s41684-021-00755-6
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, resources, pathology, primates
Summary of Study: Because the SARS-CoV-2 pandemic has significantly increased the demand for rhesus macaques biomedical researchers will need to consider alternative NHP models for COVID-19 research and for other biomedical research studies. The authors suggest alternatives.
References: PMID: 33785923 / doi: 10.1038/s41684-021-00755-6
Contact Info: Michael Chang: chang,[email protected]
URL: https://www.nature.com/articles/s41684-021-00755-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: NCR Biotech Science Cluster; Indian Institute of Technology Kharagpur; Krishi Vigyan Kendra; Inter University Centre for Biomedical Research and Super Speciality Hospital
Keywords: SARS-CoV-2, zoonotic diseases, one health approach, multiple species, primates
Summary of Study: This review examines the different natural and experimentally induced cases of human to animal SARS-CoV-2 infection (reverse zoonosis).
References: PMID: 34903944 / doi: 10.14202/vetworld.2021.2817-2826
Contact Info: R. Kumar Pramod: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654767/pdf/Vetworld-14-2817.pdf
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: NCR Biotech Science Cluster; Indian Institute of Technology Kharagpur; Krishi Vigyan Kendra; Inter University Centre for Biomedical Research and Super Speciality Hospital
Keywords: SARS-CoV-2, zoonotic diseases, one health approach, multiple species, primates
Summary of Study: This review examines the different natural and experimentally induced cases of human to animal SARS-CoV-2 infection (reverse zoonosis).
References: PMID: 34903944 / doi: 10.14202/vetworld.2021.2817-2826
Contact Info: R. Kumar Pramod: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654767/pdf/Vetworld-14-2817.pdf
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Sichuan University; Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, review of the current animal models, pathology, immune response, use for the testing therapeutics and vaccines, mice, hamsters, nonhuman primates, and ferrets
Summary of Study: A variety of animal models have been developed to demonstrate the transmission, pathogenesis, and immunology induced by SARS-CoV-2 and to evaluate the immunomodulatory and antiviral drugs and vaccines against COVID-19. None of these models can completely recapitulate the changes seen in COVID-19 patients. It may be beneficial for investigators to apply appropriate options of animal models depending on the scientific goals.
References: PMID: 34909757 / doi: 10.1002/mco2.98
Contact Info: Shuaiyao Lu: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662225/pdf/MCO2-2-548.pdf
NHP Species: african green monkeys, rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Sichuan University; Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, review of the current animal models, pathology, immune response, use for the testing therapeutics and vaccines, mice, hamsters, nonhuman primates, and ferrets
Summary of Study: A variety of animal models have been developed to demonstrate the transmission, pathogenesis, and immunology induced by SARS-CoV-2 and to evaluate the immunomodulatory and antiviral drugs and vaccines against COVID-19. None of these models can completely recapitulate the changes seen in COVID-19 patients. It may be beneficial for investigators to apply appropriate options of animal models depending on the scientific goals.
References: PMID: 34909757 / doi: 10.1002/mco2.98
Contact Info: Shuaiyao Lu: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662225/pdf/MCO2-2-548.pdf
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Tulane National primate Research Center; Tulane School of Medicine; Duke University Medical Center
Keywords: SARS-CoV-2, anti-SARS-CoV-2 monoclonal antibodies, pharmacokinetics, immune response, primates
Summary of Study: A combination of two high-affinity anti-SARS-CoV-2 monoclonal antibodies (mAbs; C144-LS and C135-LS) effectively blocks development of COVID-19 in the rhesus disease model and accelerates the prospect of clinical studies with this effective antibody combination.
References: PMID: 34869063 / doi: 10.3389/fcimb.2021.753444
Contact Info: Chad Roy: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637877/
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Tulane National primate Research Center; Tulane School of Medicine; Duke University Medical Center
Keywords: SARS-CoV-2, anti-SARS-CoV-2 monoclonal antibodies, pharmacokinetics, immune response, primates
Summary of Study: A combination of two high-affinity anti-SARS-CoV-2 monoclonal antibodies (mAbs; C144-LS and C135-LS) effectively blocks development of COVID-19 in the rhesus disease model and accelerates the prospect of clinical studies with this effective antibody combination.
References: PMID: 34869063 / doi: 10.3389/fcimb.2021.753444
Contact Info: Chad Roy: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637877/
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Amsterdam; University Paris-Saclay, Inserm, CEA; AIMM Therapeutics BV; J&S Preclinical Solutions; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, variants of concern, third vaccination, mice, rabbits, primates
Summary of Study: A third immunization improves neutralizing antibody titers against the variants-of-concern (Alpha, Beta, Gamma, and Delta).
References: PMID: 34862406 / doi: 10.1038/s41541-021-00411-7
Contact Info: Rogier Sanders: [email protected]
URL: https://www.nature.com/articles/s41541-021-00411-7
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Amsterdam; University Paris-Saclay, Inserm, CEA; AIMM Therapeutics BV; J&S Preclinical Solutions; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, variants of concern, third vaccination, mice, rabbits, primates
Summary of Study: A third immunization improves neutralizing antibody titers against the variants-of-concern (Alpha, Beta, Gamma, and Delta).
References: PMID: 34862406 / doi: 10.1038/s41541-021-00411-7
Contact Info: Rogier Sanders: [email protected]
URL: https://www.nature.com/articles/s41541-021-00411-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, pigtail macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Fred Hutchinson Cancer Research Center; University of Washington; Washington National Primate Research Center; NIAID
Keywords: SARS-CoV-2, phage-based deep mutational scanning, epitope targets, spike protein, humans, primates
Summary of Study: Findings suggest that the antibody response to SARS-CoV-2 in macaques shares many features with humans, but with substantial differences in the recognition of certain epitopes and considerable individual variability in antibody escape profiles, suggesting a diverse repertoire of antibodies that can respond to major epitopes in both humans and macaques.
References: PMID: 34909774 / doi: 10.1101/2021.12.01.470697
Contact Info: Julie Overbaugh: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.12.01.470697v1
NHP Species: rhesus macaques, pigtail macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Fred Hutchinson Cancer Research Center; University of Washington; Washington National Primate Research Center; NIAID
Keywords: SARS-CoV-2, phage-based deep mutational scanning, epitope targets, spike protein, humans, primates
Summary of Study: Findings suggest that the antibody response to SARS-CoV-2 in macaques shares many features with humans, but with substantial differences in the recognition of certain epitopes and considerable individual variability in antibody escape profiles, suggesting a diverse repertoire of antibodies that can respond to major epitopes in both humans and macaques.
References: PMID: 34909774 / doi: 10.1101/2021.12.01.470697
Contact Info: Julie Overbaugh: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.12.01.470697v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: therapeutics
NPRC/Institute: Chinese Academy of Medical Science and Peking Union Medical College; Genuine Biotech, Inc.; Wuhan Research Center for Infectious Diseases and Cancer; The First Affiliated Hospital of Henan University of Chinese Medicine; Henan Provincial Peoples Hospital; Henan Normal University; Zhengzhou University
Keywords: SARS-CoV-2, Azvudine, preclinical studies, Phase III trial, humans, primates
Summary of Study: Treating SARS-CoV-2 infected rhesus macaques with FNC reduced viral load, recuperated the thymus, improved lymphocyte profiles, alleviated inflammation and organ damage, and lessened ground-glass opacities in chest X-ray.
References: PMID: 34873151 / doi: 10.1038/s41392-021-00835-6
Contact Info: Zhenshun Cheng: [email protected]; Jun-Biao Chang: [email protected]; Jian-Dong Jiang: [email protected]
URL: https://www.nature.com/articles/s41392-021-00835-6
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: therapeutics
NPRC/Institute: Chinese Academy of Medical Science and Peking Union Medical College; Genuine Biotech, Inc.; Wuhan Research Center for Infectious Diseases and Cancer; The First Affiliated Hospital of Henan University of Chinese Medicine; Henan Provincial Peoples Hospital; Henan Normal University; Zhengzhou University
Keywords: SARS-CoV-2, Azvudine, preclinical studies, Phase III trial, humans, primates
Summary of Study: Treating SARS-CoV-2 infected rhesus macaques with FNC reduced viral load, recuperated the thymus, improved lymphocyte profiles, alleviated inflammation and organ damage, and lessened ground-glass opacities in chest X-ray.
References: PMID: 34873151 / doi: 10.1038/s41392-021-00835-6
Contact Info: Zhenshun Cheng: [email protected]; Jun-Biao Chang: [email protected]; Jian-Dong Jiang: [email protected]
URL: https://www.nature.com/articles/s41392-021-00835-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Nanogen Pharmaceutical Biotechnology Joint Stock Company; National Institute of Hygiene and Epidemiology (Hanoi, Vietnam)
Keywords: SARS-CoV-2, protein subunit vaccine, Nanocovax, pathogenesis, mice, hamsters, primates
Summary of Study: Nanocovax, a SARS-CoV-2 vaccine candidates based on recombinant protein production of the extracellular portion of the spike protein, was shown to be safe and effective in three animal models.
References: PMID: 34938290 / doi: 10.3389/fimmu.2021.766112
Contact Info: Min Si Do: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.766112/full
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Nanogen Pharmaceutical Biotechnology Joint Stock Company; National Institute of Hygiene and Epidemiology (Hanoi, Vietnam)
Keywords: SARS-CoV-2, protein subunit vaccine, Nanocovax, pathogenesis, mice, hamsters, primates
Summary of Study: Nanocovax, a SARS-CoV-2 vaccine candidates based on recombinant protein production of the extracellular portion of the spike protein, was shown to be safe and effective in three animal models.
References: PMID: 34938290 / doi: 10.3389/fimmu.2021.766112
Contact Info: Min Si Do: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.766112/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID; Emory University Vaccine Center; BIOQUAL; Moderna; Johns Hopkins University
Keywords: SARS-CoV-2, variants of concern, booster, immune response, primates
Summary of Study: An additional, delayed boost with mRNA vaccines matched to either the original vaccine strain or to the heterologous challenge strain can have a marked and sustained effect on increasing the breadth of neutralization against all VOCs tested and protection in both the lower and upper airways against the beta variant.
References: PMID: 34672695 / doi: 10.1126/science.abl8912
Contact Info: Robert Seder: [email protected]; Barney Graham: [email protected]
URL: https://www.science.org/doi/10.1126/science.abl8912?url_ver=Z39.88-2003&rfr_id=…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID; Emory University Vaccine Center; BIOQUAL; Moderna; Johns Hopkins University
Keywords: SARS-CoV-2, variants of concern, booster, immune response, primates
Summary of Study: An additional, delayed boost with mRNA vaccines matched to either the original vaccine strain or to the heterologous challenge strain can have a marked and sustained effect on increasing the breadth of neutralization against all VOCs tested and protection in both the lower and upper airways against the beta variant.
References: PMID: 34672695 / doi: 10.1126/science.abl8912
Contact Info: Robert Seder: [email protected]; Barney Graham: [email protected]
URL: https://www.science.org/doi/10.1126/science.abl8912?url_ver=Z39.88-2003&rfr_id=…
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Florida State University; University of Texas Medical Branch; Perelman School of Medicine; Duke University Medical Center; Johns Hopkins School of Medicine
Keywords: SARS-CoV-2, respiratory viral challenge, immune response, pathology, primates
Summary of Study: Data demonstrate that SARS-CoV-2 infection of pigtail macaques recapitulates important features of COVID-19 and reveals new immune and viral dynamics and thus may serve as a useful animal model for studying pathogenesis and testing vaccines and therapeutics.
References: PMID: 34929014 / doi: 10.1371/journal.ppat.1010162
Contact Info: Nicholas Maness: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010162
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Florida State University; University of Texas Medical Branch; Perelman School of Medicine; Duke University Medical Center; Johns Hopkins School of Medicine
Keywords: SARS-CoV-2, respiratory viral challenge, immune response, pathology, primates
Summary of Study: Data demonstrate that SARS-CoV-2 infection of pigtail macaques recapitulates important features of COVID-19 and reveals new immune and viral dynamics and thus may serve as a useful animal model for studying pathogenesis and testing vaccines and therapeutics.
References: PMID: 34929014 / doi: 10.1371/journal.ppat.1010162
Contact Info: Nicholas Maness: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010162
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Statens Serum Institute; Robert Koch Institute; BIOQUAL; University of Southern Denmark
Keywords: SARS-CoV-2, DNA plasmid vaccine, immune response, primates
Summary of Study: The candidate plasmid DNA vaccine encoding the SARS-CoV-2 spike protein is immunogenic in different models and confers protection against lung infection in nonhuman primates. Further evaluation of this DNA vaccine candidate in clinical trials is warranted.
References: PMID: 34930909 / doi: 10.1038/s41541-021-00419-z
Contact Info: Anders Fomsgaard: [email protected]
URL: https://www.nature.com/articles/s41541-021-00419-z
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Statens Serum Institute; Robert Koch Institute; BIOQUAL; University of Southern Denmark
Keywords: SARS-CoV-2, DNA plasmid vaccine, immune response, primates
Summary of Study: The candidate plasmid DNA vaccine encoding the SARS-CoV-2 spike protein is immunogenic in different models and confers protection against lung infection in nonhuman primates. Further evaluation of this DNA vaccine candidate in clinical trials is warranted.
References: PMID: 34930909 / doi: 10.1038/s41541-021-00419-z
Contact Info: Anders Fomsgaard: [email protected]
URL: https://www.nature.com/articles/s41541-021-00419-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, pigtail macaques, african green monkeys, squirrel monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIAID
Keywords: SARS-CoV-2, pulmonary histopathologic characteristics, immunohistochemistry, species comparison, primates
Summary of Study: Histopathology does not appear to be a superior readout for interpretation of vaccine and therapeutic evaluations in the NHPs studied. The recommendation of which NHP is a superior model should be based on virology data as well as further work on genetic factors that contribute to significant disease.
References: PMID: 34963391 / doi: 10.1177/03009858211067468
Contact Info: Chad Clancy: [email protected]
URL: https://journals.sagepub.com/doi/10.1177/03009858211067468?url_ver=Z39.88-2003&…
NHP Species: rhesus macaques, pigtail macaques, african green monkeys, squirrel monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIAID
Keywords: SARS-CoV-2, pulmonary histopathologic characteristics, immunohistochemistry, species comparison, primates
Summary of Study: Histopathology does not appear to be a superior readout for interpretation of vaccine and therapeutic evaluations in the NHPs studied. The recommendation of which NHP is a superior model should be based on virology data as well as further work on genetic factors that contribute to significant disease.
References: PMID: 34963391 / doi: 10.1177/03009858211067468
Contact Info: Chad Clancy: [email protected]
URL: https://journals.sagepub.com/doi/10.1177/03009858211067468?url_ver=Z39.88-2003&…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIH
Keywords: SARS-CoV-2, review, different primate species
Summary of Study: The authors advocate for baboons as a viable alternative to rhesus macaques in SARS-CoV-2 research.
References: PMID: 33785923 / doi:10.1038/s41684-021-00755-6
Contact Info: Michael Chang: [email protected]
URL: https://www.nature.com/articles/s41684-021-00755-6
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIH
Keywords: SARS-CoV-2, review, different primate species
Summary of Study: The authors advocate for baboons as a viable alternative to rhesus macaques in SARS-CoV-2 research.
References: PMID: 33785923 / doi:10.1038/s41684-021-00755-6
Contact Info: Michael Chang: [email protected]
URL: https://www.nature.com/articles/s41684-021-00755-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIH
Keywords: SARS-CoV-2, single-cell RNA sequencing, lung cells, primates
Summary of Study: Monocyte-derived macrophages recruited to the lungs, rather than tissue-resident alveolar macrophages, were most likely to be responsible for phagocytosis of infected cells and cellular debris early in infection, with their roles switching during clearance of infection.
References: PMID: 33431511 / doi: 10.1126/scitranslmed.abe8146
Contact Info: Emmie DeWit: [email protected]
URL: https://stm.sciencemag.org/content/13/578/eabe8146.short
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIH
Keywords: SARS-CoV-2, single-cell RNA sequencing, lung cells, primates
Summary of Study: Monocyte-derived macrophages recruited to the lungs, rather than tissue-resident alveolar macrophages, were most likely to be responsible for phagocytosis of infected cells and cellular debris early in infection, with their roles switching during clearance of infection.
References: PMID: 33431511 / doi: 10.1126/scitranslmed.abe8146
Contact Info: Emmie DeWit: [email protected]
URL: https://stm.sciencemag.org/content/13/578/eabe8146.short
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIAID
Keywords: SARS-CoV-2, virus genomic variants, virus replication, immune response, pathology, primates
Summary of Study: A study of pathogenesis of B.1.1.7 and B.1.351 compared to a SARS-CoV-2 isolate containing the D614G spike substitution showed that B.1.351 was slightly less pathogenic than the other two variants, but there were no differences in virus shedding between the variants that could explain increased transmissibility.
References: PMID: 34678071 / doi: 10.1126/sciadv.abj3627
Contact Info: Emmie de Wit: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.abj3627?url_ver=Z39.88-2003&rfr_id=o…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIAID
Keywords: SARS-CoV-2, virus genomic variants, virus replication, immune response, pathology, primates
Summary of Study: A study of pathogenesis of B.1.1.7 and B.1.351 compared to a SARS-CoV-2 isolate containing the D614G spike substitution showed that B.1.351 was slightly less pathogenic than the other two variants, but there were no differences in virus shedding between the variants that could explain increased transmissibility.
References: PMID: 34678071 / doi: 10.1126/sciadv.abj3627
Contact Info: Emmie de Wit: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.abj3627?url_ver=Z39.88-2003&rfr_id=o…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: NCI/NIH
Keywords: SARS-CoV-2, ACE2, type I interferon, pathology, primates
Summary of Study: Type I interferon mediates an important innate immune response against viral infection by directly inhibiting viral replication. It also bridges innate to adaptive immunity for long-term protection against viral reinfections.
References: PMID: 34149696 / doi: 10.3389/fimmu.2021.658428
Contact Info: Yongjun Sui: [email protected]; Jay Berzofsky: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.658428/full
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: NCI/NIH
Keywords: SARS-CoV-2, ACE2, type I interferon, pathology, primates
Summary of Study: Type I interferon mediates an important innate immune response against viral infection by directly inhibiting viral replication. It also bridges innate to adaptive immunity for long-term protection against viral reinfections.
References: PMID: 34149696 / doi: 10.3389/fimmu.2021.658428
Contact Info: Yongjun Sui: [email protected]; Jay Berzofsky: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.658428/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, animal models, viruses, resources, primates
Summary of Study: The SARS-CoV-2/COVID-19 pandemic has significantly increased the demand for specific-pathogen-free (SPF) nonhuman primates (NHPs) for development of vaccines and therapeutics, thus straining the supply of these animals for biomedical research studies. Non-SPF animals, which are available in greater numbers and include well-characterized primate species, should be considered in lieu of limited SPF animals for appropriate research studies.
References: PMID: 34163043 / doi: 10.1038/s41684-021-008102
Contact Info: Miguel Contreras: [email protected]
URL: https://www.nature.com/articles/s41684-021-00810-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, animal models, viruses, resources, primates
Summary of Study: The SARS-CoV-2/COVID-19 pandemic has significantly increased the demand for specific-pathogen-free (SPF) nonhuman primates (NHPs) for development of vaccines and therapeutics, thus straining the supply of these animals for biomedical research studies. Non-SPF animals, which are available in greater numbers and include well-characterized primate species, should be considered in lieu of limited SPF animals for appropriate research studies.
References: PMID: 34163043 / doi: 10.1038/s41684-021-008102
Contact Info: Miguel Contreras: [email protected]
URL: https://www.nature.com/articles/s41684-021-00810-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, primates, animal resources, biosafety
Summary of Study: Sustaining and increasing NHP research capacity will require careful preparation and collaborations to improve existing infrastructure and expand established facilities, expertise, and programs.
References: PMID: 33927412 / doi: 10.1038/s41684-021-00760-9
Contact Info: Sheri Ann Hild: [email protected]
URL: https://www.nature.com/articles/s41684-021-00760-9
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, primates, animal resources, biosafety
Summary of Study: Sustaining and increasing NHP research capacity will require careful preparation and collaborations to improve existing infrastructure and expand established facilities, expertise, and programs.
References: PMID: 33927412 / doi: 10.1038/s41684-021-00760-9
Contact Info: Sheri Ann Hild: [email protected]
URL: https://www.nature.com/articles/s41684-021-00760-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP, NIH
Keywords: SARS-CoV-2, the use of primates for COVID research, animal resources
Summary of Study: The SARS-CoV-2/COVID-19 pandemic has significantly increased the demand for specific-pathogen-free (SFP) NHPs for development of vaccines and therapeutics. Non-SPF animals, which are available in greater numbers and include well-characterized primate species, should be considered in lieu of limited SPF animals for appropriate research studies.
References: doi: 10.1038/s41684-021-00810-2
Contact Info: Miguel Contreras: miguel.contreras
URL: https://www.nature.com/articles/s41684-021-00810-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP, NIH
Keywords: SARS-CoV-2, the use of primates for COVID research, animal resources
Summary of Study: The SARS-CoV-2/COVID-19 pandemic has significantly increased the demand for specific-pathogen-free (SFP) NHPs for development of vaccines and therapeutics. Non-SPF animals, which are available in greater numbers and include well-characterized primate species, should be considered in lieu of limited SPF animals for appropriate research studies.
References: doi: 10.1038/s41684-021-00810-2
Contact Info: Miguel Contreras: miguel.contreras
URL: https://www.nature.com/articles/s41684-021-00810-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chungbuk National University
Keywords: SARS-CoV-2, several animal species, transduction, pathology, primates
Summary of Study: Review of various animal models employed for SARS-CoV-2 infection studies that outlines their individual strengths and limitations for use in studies aimed at increasing understanding of coronavirus pathogenesis.
References: PMID: 33996168 / doi: 10.4110/in.2021.21.e12
Contact Info: Young Ki Choi: [email protected]
URL: https://immunenetwork.org/DOIx.php?id=10.4110/in.2021.21.e12
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chungbuk National University
Keywords: SARS-CoV-2, several animal species, transduction, pathology, primates
Summary of Study: Review of various animal models employed for SARS-CoV-2 infection studies that outlines their individual strengths and limitations for use in studies aimed at increasing understanding of coronavirus pathogenesis.
References: PMID: 33996168 / doi: 10.4110/in.2021.21.e12
Contact Info: Young Ki Choi: [email protected]
URL: https://immunenetwork.org/DOIx.php?id=10.4110/in.2021.21.e12
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Wheaten College, Cornell University
Keywords: SARS-CoV-2, virus susceptibility, animal welfare, hamsters, ferrets, primates
Summary of Study: Paper reviews virus susceptibilities in species with frequent human contact, and factors that are best predictors of virus susceptibility.
References: PMID: 34359172 / doi: 10.3390/ani11072044
Contact Info: Kathleen Morgan: [email protected]
URL: https://www.mdpi.com/2076-2615/11/7/2044
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Wheaten College, Cornell University
Keywords: SARS-CoV-2, virus susceptibility, animal welfare, hamsters, ferrets, primates
Summary of Study: Paper reviews virus susceptibilities in species with frequent human contact, and factors that are best predictors of virus susceptibility.
References: PMID: 34359172 / doi: 10.3390/ani11072044
Contact Info: Kathleen Morgan: [email protected]
URL: https://www.mdpi.com/2076-2615/11/7/2044
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, inactivated vaccines, antibody-dependent enhancement, immunopathology, primates
Summary of Study: Results show that in the absence of cellular immunity, passive infusion of subneutralizing or nonneutralizing anti-SARS-CoV-2 antibodies could still provide some level of protection against infection upon challenge, and no low-level antibody-enhanced infection was observed.
References: PMID: 34736354 / doi: 10.1080/22221751.2021.2002670
Contact Info: Qihan Li: [email protected]; Longding Liu: [email protected]; Cunbao Liu: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2002670
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, inactivated vaccines, antibody-dependent enhancement, immunopathology, primates
Summary of Study: Results show that in the absence of cellular immunity, passive infusion of subneutralizing or nonneutralizing anti-SARS-CoV-2 antibodies could still provide some level of protection against infection upon challenge, and no low-level antibody-enhanced infection was observed.
References: PMID: 34736354 / doi: 10.1080/22221751.2021.2002670
Contact Info: Qihan Li: [email protected]; Longding Liu: [email protected]; Cunbao Liu: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2002670
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Texas Medical Branch
Keywords: SARS-CoV-2, convalescent sera, primates
Summary of Study: Convalescent plasma therapy in humans may be an effective strategy provided that donor sera contain high anti-SARS-CoV-2 neutralizing titers given in early states of the disease.
References: PMID: 33662255 / doi: 10.1016/j.celrep.2021.108837
Contact Info: Thomas W. Geisbert:
URL: https://www.sciencedirect.com/science/article/pii/S2211124721001510?via%3Dihub=
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Texas Medical Branch
Keywords: SARS-CoV-2, convalescent sera, primates
Summary of Study: Convalescent plasma therapy in humans may be an effective strategy provided that donor sera contain high anti-SARS-CoV-2 neutralizing titers given in early states of the disease.
References: PMID: 33662255 / doi: 10.1016/j.celrep.2021.108837
Contact Info: Thomas W. Geisbert:
URL: https://www.sciencedirect.com/science/article/pii/S2211124721001510?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Texas Medical Branch
Keywords: SARS-CoV-2, apoptosis, lung tissues, pathology, primates
Summary of Study: Significant increases in apoptotic signals in postmortem lung sections from COVID-19 patients and lungs of NHPs infected with SARS-CoV-2 on day 21 p.i.
References: PMID: 33922476 / doi: 10.3390/pathogens10050509
Contact Info: Paul Boor: [email protected]; Jason Comer: [email protected]; Bin Gong: [email protected]
URL: https://www.mdpi.com/2076-0817/10/5/509
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Texas Medical Branch
Keywords: SARS-CoV-2, apoptosis, lung tissues, pathology, primates
Summary of Study: Significant increases in apoptotic signals in postmortem lung sections from COVID-19 patients and lungs of NHPs infected with SARS-CoV-2 on day 21 p.i.
References: PMID: 33922476 / doi: 10.3390/pathogens10050509
Contact Info: Paul Boor: [email protected]; Jason Comer: [email protected]; Bin Gong: [email protected]
URL: https://www.mdpi.com/2076-0817/10/5/509
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: USC, , UCLA, City of Hope, Bioqual
Keywords: SARS-CoV-2, pancreatic beta cells, toxicity, metabolism, primates
Summary of Study: SARS-CoV-2 infection enhances beta cell stress that may compromise beta-cell function beyond the duration of the disease course, raising the possibility that the beta cell stress and injury may have clinical implications to the long-term future health of patients that have recovered from COVID19.
References: PMID: 34312617 / doi: 10.21203/rs.3.rs-592374/v1
Contact Info: Senta Georgia: [email protected]
URL: https://www.researchsquare.com/article/rs-592374/v1
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: USC, , UCLA, City of Hope, Bioqual
Keywords: SARS-CoV-2, pancreatic beta cells, toxicity, metabolism, primates
Summary of Study: SARS-CoV-2 infection enhances beta cell stress that may compromise beta-cell function beyond the duration of the disease course, raising the possibility that the beta cell stress and injury may have clinical implications to the long-term future health of patients that have recovered from COVID19.
References: PMID: 34312617 / doi: 10.21203/rs.3.rs-592374/v1
Contact Info: Senta Georgia: [email protected]
URL: https://www.researchsquare.com/article/rs-592374/v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Beijing DanXu Biopharmaceuticals
Keywords: SARS-CoV-2, monoclonal antibody, ELISA assay, pharmacokinetic, primates
Summary of Study: In cynomolgus monkeys, BD-604 (a fully human monoclonal antibody) possesses pharmacokinetic properties similar to natural IgGs.
References: PMID: 34215019 / doi: 10.1002/dta.3122
Contact Info: Xu Zhang: [email protected]
URL: https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/dta.3122
NHP Species:
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Beijing DanXu Biopharmaceuticals
Keywords: SARS-CoV-2, monoclonal antibody, ELISA assay, pharmacokinetic, primates
Summary of Study: In cynomolgus monkeys, BD-604 (a fully human monoclonal antibody) possesses pharmacokinetic properties similar to natural IgGs.
References: PMID: 34215019 / doi: 10.1002/dta.3122
Contact Info: Xu Zhang: [email protected]
URL: https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/dta.3122
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Weill Cornell Medical College
Keywords: SARS-CoV-2, vaccines, antibody and T cell immunogenicity, review, primates
Summary of Study: This review article looks at what is known of the antibody and T cell immunogenicity of vaccines that have advanced to human clinical trials. Includes summary of press releases on the outcomes of vaccine efficacy trials.
References: PMID: 33608249 / doi: 10.1126/sciadv.abe8065
Contact Info: John P. Moore: [email protected]
URL: https://advances.sciencemag.org/content/7/12/eabe8065
NHP Species: multiple species
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Weill Cornell Medical College
Keywords: SARS-CoV-2, vaccines, antibody and T cell immunogenicity, review, primates
Summary of Study: This review article looks at what is known of the antibody and T cell immunogenicity of vaccines that have advanced to human clinical trials. Includes summary of press releases on the outcomes of vaccine efficacy trials.
References: PMID: 33608249 / doi: 10.1126/sciadv.abe8065
Contact Info: John P. Moore: [email protected]
URL: https://advances.sciencemag.org/content/7/12/eabe8065
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Weill Cornell Medical College
Keywords: SARS-CoV-2, antibody and T cell immunogenicity, testing vaccines in humans and primates, review
Summary of Study: This review article summaries what is known of the antibody and T cell immunogenicity of multiple preventive vaccines in NHPs and humans.
References: PMID: 33608249 / doi: 10.1126/sciadv.abe8065
Contact Info: John Moore: [email protected]
URL: https://advances.sciencemag.org/content/7/12/eabe8065
NHP Species: multiple species
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Weill Cornell Medical College
Keywords: SARS-CoV-2, antibody and T cell immunogenicity, testing vaccines in humans and primates, review
Summary of Study: This review article summaries what is known of the antibody and T cell immunogenicity of multiple preventive vaccines in NHPs and humans.
References: PMID: 33608249 / doi: 10.1126/sciadv.abe8065
Contact Info: John Moore: [email protected]
URL: https://advances.sciencemag.org/content/7/12/eabe8065
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, marmosets
Year Published: 2021
Study Type/Review:
NPRC/Institute: Southwest NPRC
Keywords: SARS-CoV-2, young and old animals, Acute respiratory distress, primates
Summary of Study: Acute respiratory distress in macaques and baboons recapitulates the progression of COVID-19 in humans, making them suitable as models to test vaccines and therapies.
References: PMID: 33340034/doi: 10.1038/s41564-020-00841-4
Contact Info: Deepak Kaushal: [email protected]
URL: https://www.nature.com/articles/s41564-020-00841-4
NHP Species: rhesus macaques, marmosets
Year Published: 2021
Study Type/Review:
NPRC/Institute: Southwest NPRC
Keywords: SARS-CoV-2, young and old animals, Acute respiratory distress, primates
Summary of Study: Acute respiratory distress in macaques and baboons recapitulates the progression of COVID-19 in humans, making them suitable as models to test vaccines and therapies.
References: PMID: 33340034/doi: 10.1038/s41564-020-00841-4
Contact Info: Deepak Kaushal: [email protected]
URL: https://www.nature.com/articles/s41564-020-00841-4