Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: MIT; Harvard Medical School; University of Kansas; Tufts University; SpyBiotech Limited; Bioqual; Bill and Melinda Gates Medical Research Institute; Serum Institute of India; University of Oxford; Ragon Institute of MGH, MIT, and Harvard; Massachusetts Consortium on Pathogen Readiness
Keywords: SARS-CoV-2, receptor binding domain, HBsAg virus–like particles, immune response, primates
Summary of Study: A clinical-stage vaccine candidate comprising a SARS-CoV-2 receptor binding domain-hepatitis B surface antigen virus-like particle elicited protective immunity in cynomolgus macaques.
References: PMID: 35294244 / doi: 10.1126/sciadv.abl6015
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.abl6015?url_ver=Z39.88-2003&rfr_id=o…
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: MIT; Harvard Medical School; University of Kansas; Tufts University; SpyBiotech Limited; Bioqual; Bill and Melinda Gates Medical Research Institute; Serum Institute of India; University of Oxford; Ragon Institute of MGH, MIT, and Harvard; Massachusetts Consortium on Pathogen Readiness
Keywords: SARS-CoV-2, receptor binding domain, HBsAg virus–like particles, immune response, primates
Summary of Study: A clinical-stage vaccine candidate comprising a SARS-CoV-2 receptor binding domain-hepatitis B surface antigen virus-like particle elicited protective immunity in cynomolgus macaques.
References: PMID: 35294244 / doi: 10.1126/sciadv.abl6015
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.abl6015?url_ver=Z39.88-2003&rfr_id=o…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Tufts University Cummings School of Veterinary Medicine; Vaccine & Gene Therapy Institute/OHSU; University of Montreal; Oregon National Primate Research Center; Ragon Institute of MGH, MIT, and Harvard
Keywords: SARS-CoV-2, Ad26.COV2.S vaccine, transcriptional and proteomic profiling, primates
Summary of Study: Study showed that vaccination with Ad26.COV2.S protected hamsters and rhesus macaques challenged with SARS-CoV-2 from developing excessive proinflammatory responses mediated by IL-6 and IL-1, macrophages, and neutrophil activation.
References: PMID: 35395058 / doi: 10.1371/journal.ppat.1009990
Contact Info: Dan Barouch: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009990
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Tufts University Cummings School of Veterinary Medicine; Vaccine & Gene Therapy Institute/OHSU; University of Montreal; Oregon National Primate Research Center; Ragon Institute of MGH, MIT, and Harvard
Keywords: SARS-CoV-2, Ad26.COV2.S vaccine, transcriptional and proteomic profiling, primates
Summary of Study: Study showed that vaccination with Ad26.COV2.S protected hamsters and rhesus macaques challenged with SARS-CoV-2 from developing excessive proinflammatory responses mediated by IL-6 and IL-1, macrophages, and neutrophil activation.
References: PMID: 35395058 / doi: 10.1371/journal.ppat.1009990
Contact Info: Dan Barouch: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009990
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Cellid Co., Ltd; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology; International Vaccine Institute; Seoul National University
Keywords: SARS-CoV-2, adenovirus, AdCLD-CoV19 vaccine, immune response, virus variants, primates
Summary of Study: AdCLD-CoV19 can prevent SARS-CoV-2 with a single vaccination, and the new vaccine administration strategy that responds to various variants can maintain the efficacy of the vaccine.
References: PMID: 35632468 / doi: 10.3390/vaccines10050712
Contact Info: Chang-Yuil Kang: [email protected]
URL: https://www.mdpi.com/2076-393X/10/5/712
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Cellid Co., Ltd; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology; International Vaccine Institute; Seoul National University
Keywords: SARS-CoV-2, adenovirus, AdCLD-CoV19 vaccine, immune response, virus variants, primates
Summary of Study: AdCLD-CoV19 can prevent SARS-CoV-2 with a single vaccination, and the new vaccine administration strategy that responds to various variants can maintain the efficacy of the vaccine.
References: PMID: 35632468 / doi: 10.3390/vaccines10050712
Contact Info: Chang-Yuil Kang: [email protected]
URL: https://www.mdpi.com/2076-393X/10/5/712
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Bordeaux; Université Paris-Saclay; Vaccine Research Institute Créteil; Inserm U955 Créteil; Baylor Scott and White Research Institute; Institut Pasteur Paris; CNRS UMR 3569; University of Amsterdam Amsterdam Infection & Immunity Institute Amsterdam; Hôpital Henri-Mondor Albert-Chenevier; CHU Bordeaux
Keywords: SARS-CoV-2, mathematical modelling, vaccine, viral dynamics, primates
Summary of Study: A model-based approach can identify mechanistic correlates of protection that vaccines provide against infection, such that inhibition of the receptor-binding domain to ACE2 represents a strong mechanism of protection.
References: PMID: 35801637 / doi: 10.7554/eLife.75427
Contact Info: Rodolphe Thiébaut: [email protected]
URL: https://elifesciences.org/articles/75427
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Bordeaux; Université Paris-Saclay; Vaccine Research Institute Créteil; Inserm U955 Créteil; Baylor Scott and White Research Institute; Institut Pasteur Paris; CNRS UMR 3569; University of Amsterdam Amsterdam Infection & Immunity Institute Amsterdam; Hôpital Henri-Mondor Albert-Chenevier; CHU Bordeaux
Keywords: SARS-CoV-2, mathematical modelling, vaccine, viral dynamics, primates
Summary of Study: A model-based approach can identify mechanistic correlates of protection that vaccines provide against infection, such that inhibition of the receptor-binding domain to ACE2 represents a strong mechanism of protection.
References: PMID: 35801637 / doi: 10.7554/eLife.75427
Contact Info: Rodolphe Thiébaut: [email protected]
URL: https://elifesciences.org/articles/75427
Coronavirus Investigated: SARS-CoV-2
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Université Paris-Saclay; Université de Paris; Laboratoire de Pharmacocinétique et Toxicologie; Institut Pasteur; Centre International de Recherche en Infectiologie; Unité des Virus Emergents, Aix Marseille Univ; VirNext, Université Claude Bernard Lyon 1; University Hospital, Bordeaux & Inserm
Keywords: SARS-CoV-2, Zika, favipiravir, antiviral activity, primates
Summary of Study: A nucleoside analogue with activity against RNA viruses shows antiviral activity that reduces viral load and kinetics in Zika, but not COVID-19.
References: PMID: 36042198 / doi: 10.1038/s41467-022-32565-w
Contact Info: Roger Le Grand: [email protected]; Jeremie Guedj: [email protected]
URL: https://www.nature.com/articles/s41467-022-32565-w
NHP Species: cynomolgus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Université Paris-Saclay; Université de Paris; Laboratoire de Pharmacocinétique et Toxicologie; Institut Pasteur; Centre International de Recherche en Infectiologie; Unité des Virus Emergents, Aix Marseille Univ; VirNext, Université Claude Bernard Lyon 1; University Hospital, Bordeaux & Inserm
Keywords: SARS-CoV-2, Zika, favipiravir, antiviral activity, primates
Summary of Study: A nucleoside analogue with activity against RNA viruses shows antiviral activity that reduces viral load and kinetics in Zika, but not COVID-19.
References: PMID: 36042198 / doi: 10.1038/s41467-022-32565-w
Contact Info: Roger Le Grand: [email protected]; Jeremie Guedj: [email protected]
URL: https://www.nature.com/articles/s41467-022-32565-w
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chulalongkorn University, Bangkok, Thailand; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathum Thani, Thailand; Baiya Phytopharm Co., Ltd., Bangkok, Thailand; Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand; National Primate Research Center of Thailand-Chulalongkorn University, Saraburi, Thailand.
Keywords: SARS-CoV-2, recombinant subunit vaccine, plants, immune response, mice, primates
Summary of Study: Three-dose regimen of Baiya SARS-CoV-2 Vax 1 vaccine elicits neutralizing immune response against SARS-CoV-2 variants.
References: doi: 10.3389/fpls.2022.901978
Contact Info: Waranyoo Phoolcharoen: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fpls.2022.901978/full
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Chulalongkorn University, Bangkok, Thailand; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathum Thani, Thailand; Baiya Phytopharm Co., Ltd., Bangkok, Thailand; Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand; National Primate Research Center of Thailand-Chulalongkorn University, Saraburi, Thailand.
Keywords: SARS-CoV-2, recombinant subunit vaccine, plants, immune response, mice, primates
Summary of Study: Three-dose regimen of Baiya SARS-CoV-2 Vax 1 vaccine elicits neutralizing immune response against SARS-CoV-2 variants.
References: doi: 10.3389/fpls.2022.901978
Contact Info: Waranyoo Phoolcharoen: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fpls.2022.901978/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIBSC Division of Infectious Disease Diagnostics, Division of Virology, Division of Analytical and Biological Sciences, other, Hertfordshire, UK
Keywords: SARS-CoV-2, virology, molecular and pathological outcomes, several animal species, primates
Summary of Study: Viral outcomes in multiple species
References: doi: 10.1038/s41598-022-23339-x
Contact Info: Neil Berry: [email protected]
URL: https://www.nature.com/articles/s41598-022-23339-x
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIBSC Division of Infectious Disease Diagnostics, Division of Virology, Division of Analytical and Biological Sciences, other, Hertfordshire, UK
Keywords: SARS-CoV-2, virology, molecular and pathological outcomes, several animal species, primates
Summary of Study: Viral outcomes in multiple species
References: doi: 10.1038/s41598-022-23339-x
Contact Info: Neil Berry: [email protected]
URL: https://www.nature.com/articles/s41598-022-23339-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: prevention
NPRC/Institute: AstraZeneca; BIOQUAL; Vanderbilt University; USAMRIID
Keywords: SARS-CoV-2, monoclonal antibody combination, AZD7442,virus protection, humans, primates
Summary of Study: AZD7442, a monoclonal antibody comprised of AZD8895 and AZD1061, demonstrated potent in vitro neutralization against SARS-CoV-2 VOCs, in vivo efficacy in both prevention and treatment settings of SARS-CoV-2 infection in NHPs, and extended half-life in NHPs and healthy adult participants.
References: PMID: 35076282 / doi: 10.1126/scitranslmed.abl8124
Contact Info: Mark Esser: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abl8124?url_ver=Z39.88-2003&rf…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: prevention
NPRC/Institute: AstraZeneca; BIOQUAL; Vanderbilt University; USAMRIID
Keywords: SARS-CoV-2, monoclonal antibody combination, AZD7442,virus protection, humans, primates
Summary of Study: AZD7442, a monoclonal antibody comprised of AZD8895 and AZD1061, demonstrated potent in vitro neutralization against SARS-CoV-2 VOCs, in vivo efficacy in both prevention and treatment settings of SARS-CoV-2 infection in NHPs, and extended half-life in NHPs and healthy adult participants.
References: PMID: 35076282 / doi: 10.1126/scitranslmed.abl8124
Contact Info: Mark Esser: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abl8124?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Northwestern University; Tulane National Primate Research Center; NIAID; Sanford Burnham Prebys Medical Discovery Institute; Bioqual; New Iberia Research Center
Keywords: SARS-CoV-2, antibody-based in vivo probe system, lungs, primates
Summary of Study: Results provide proof of concept for the use of in vivo antibody-based probes to study SARS-CoV-2 infection dynamics in rhesus macaques.
References: PMID: 35003140 / doi: 10.3389/fimmu.2021.810047
Contact Info: Thomas Hope: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.810047/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Northwestern University; Tulane National Primate Research Center; NIAID; Sanford Burnham Prebys Medical Discovery Institute; Bioqual; New Iberia Research Center
Keywords: SARS-CoV-2, antibody-based in vivo probe system, lungs, primates
Summary of Study: Results provide proof of concept for the use of in vivo antibody-based probes to study SARS-CoV-2 infection dynamics in rhesus macaques.
References: PMID: 35003140 / doi: 10.3389/fimmu.2021.810047
Contact Info: Thomas Hope: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.810047/full
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Ragon Institution of MGH, MIT, and Harvard; Bioqual; Washington University School of Medicine; Emory School of Medicine, Tufts University Cummings School of Veterinary Medicine
Keywords: SARS-CoV-2, mRNA-based BNT162b2 vaccine, virus variants, immune response, primates
Summary of Study: BNT162b2 and Ad26.COV2.S provided robust protection against high-dose challenge with the SARS-CoV-2 Omicron variant in macaques. Protection against this highly mutated SARS-CoV-2 variant correlated with both humoral and cellular immune responses.
References: PMID: 35169798 / doi: 10.1101/2022.02.06.479285
Contact Info: Dan Barouch: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.02.06.479285v1
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beth Israel Deaconess Medical Center; Ragon Institution of MGH, MIT, and Harvard; Bioqual; Washington University School of Medicine; Emory School of Medicine, Tufts University Cummings School of Veterinary Medicine
Keywords: SARS-CoV-2, mRNA-based BNT162b2 vaccine, virus variants, immune response, primates
Summary of Study: BNT162b2 and Ad26.COV2.S provided robust protection against high-dose challenge with the SARS-CoV-2 Omicron variant in macaques. Protection against this highly mutated SARS-CoV-2 variant correlated with both humoral and cellular immune responses.
References: PMID: 35169798 / doi: 10.1101/2022.02.06.479285
Contact Info: Dan Barouch: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.02.06.479285v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; Yerkes National Primate Research Center; Emory School of Medicine; Bioqual; Modernal; Harvard T.H. Chan School of Public Health
Keywords: SARS-CoV-2, vaccination, mRNA-1273 or mRNA-Omicron boost, pathology, primates
Summary of Study: Boosting with homologous mRNA-1273 or mRNA-Omicron leads to comparable and significant increases in neutralizing antibody responses against all VOC, including Omicron.
References: PMID: 35447072 / doi: 10.1016/j.cell.2022.03.038
Contact Info: Daniel Douek: [email protected]; Robert Seder: [email protected]
URL: https://www.cell.com/cell/fulltext/S0092-8674(22)00388-9?_returnURL=https%3A//l…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID; Yerkes National Primate Research Center; Emory School of Medicine; Bioqual; Modernal; Harvard T.H. Chan School of Public Health
Keywords: SARS-CoV-2, vaccination, mRNA-1273 or mRNA-Omicron boost, pathology, primates
Summary of Study: Boosting with homologous mRNA-1273 or mRNA-Omicron leads to comparable and significant increases in neutralizing antibody responses against all VOC, including Omicron.
References: PMID: 35447072 / doi: 10.1016/j.cell.2022.03.038
Contact Info: Daniel Douek: [email protected]; Robert Seder: [email protected]
URL: https://www.cell.com/cell/fulltext/S0092-8674(22)00388-9?_returnURL=https%3A//l…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, longitudinal analyses, lungs, intestines, immune response, primates
Summary of Study: Findings indicate an imbalance of immune dynamic in intestinal mucosa during SARS-CoV-2 infection, which may underlie ongoing rectal viral shedding and mild tissue damage.
References: PMID: 35594870 / doi: 10.1016/j.celrep.2022.110864
Contact Info: Zhanlong He: [email protected]; Haijing Shi: [email protected]; Qihan Li: [email protected]; Longing Liu: [email protected]
URL: https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00637-4?_returnURL=htt…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, longitudinal analyses, lungs, intestines, immune response, primates
Summary of Study: Findings indicate an imbalance of immune dynamic in intestinal mucosa during SARS-CoV-2 infection, which may underlie ongoing rectal viral shedding and mild tissue damage.
References: PMID: 35594870 / doi: 10.1016/j.celrep.2022.110864
Contact Info: Zhanlong He: [email protected]; Haijing Shi: [email protected]; Qihan Li: [email protected]; Longing Liu: [email protected]
URL: https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00637-4?_returnURL=htt…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Zalgen Labs, LLC; Duke University Medical Center, Duke Human Vaccine Institute;
Keywords: SARS-CoV-2, viral kinetics, immune response, primates
Summary of Study: Pulmonary outcome of COVID-19 is not influenced by route of infection even though clinical onset shows differences.
References: PMID: 35789343 / doi: 10.1371/journal.ppat.1010618
Contact Info: Chad Roy: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010618
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Zalgen Labs, LLC; Duke University Medical Center, Duke Human Vaccine Institute;
Keywords: SARS-CoV-2, viral kinetics, immune response, primates
Summary of Study: Pulmonary outcome of COVID-19 is not influenced by route of infection even though clinical onset shows differences.
References: PMID: 35789343 / doi: 10.1371/journal.ppat.1010618
Contact Info: Chad Roy: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010618
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Stanford University; University of Washington; Emory National Primate Research Center, and Emory University School of Medicine; Tulane National Primate Research Center; University of Louisiana at Lafayette; University of Maryland School of Medicine; University of California, San Diego; La Jolla Institute for Immunology; GSK; Bill and Melinda Gates Foundation; Tulane University School of Medicine;
Keywords: SARS-CoV-2, adjuvanted subunit vaccine, immune response, primates
Summary of Study: An adjuvanted subunit vaccine results in significant and durable memory T- and B-cell responses to Beta and Omicron variants and was found to suppress viral load and protect lungs after Omicron infection.
References: PMID: 35976993 / doi: 10.1126/scitranslmed.abq4130
Contact Info: Bali Pulendran: [email protected]
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abq4130?rfr_dat=cr_pub%20…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Stanford University; University of Washington; Emory National Primate Research Center, and Emory University School of Medicine; Tulane National Primate Research Center; University of Louisiana at Lafayette; University of Maryland School of Medicine; University of California, San Diego; La Jolla Institute for Immunology; GSK; Bill and Melinda Gates Foundation; Tulane University School of Medicine;
Keywords: SARS-CoV-2, adjuvanted subunit vaccine, immune response, primates
Summary of Study: An adjuvanted subunit vaccine results in significant and durable memory T- and B-cell responses to Beta and Omicron variants and was found to suppress viral load and protect lungs after Omicron infection.
References: PMID: 35976993 / doi: 10.1126/scitranslmed.abq4130
Contact Info: Bali Pulendran: [email protected]
URL: https://www.science.org/doi/full/10.1126/scitranslmed.abq4130?rfr_dat=cr_pub%20…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Beijing Institute for Brain Disorders, Capital Medical University, China; State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing , numerous others.
Keywords: SARS-CoV-2, single-nucleus transcriptomics, pathology, immune response, primates
Summary of Study: Single-nucleus transcriptomic profiling of multiple organs
References: doi: 10.24272/j.issn.2095-8137.2022.443
Contact Info: Xiaoqun Wang: nc.ude.unb@gnawnuqoaix
URL: https://www.zoores.ac.cn/en/article/doi/10.24272/j.issn.2095-8137.2022.443
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Beijing Institute for Brain Disorders, Capital Medical University, China; State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing , numerous others.
Keywords: SARS-CoV-2, single-nucleus transcriptomics, pathology, immune response, primates
Summary of Study: Single-nucleus transcriptomic profiling of multiple organs
References: doi: 10.24272/j.issn.2095-8137.2022.443
Contact Info: Xiaoqun Wang: nc.ude.unb@gnawnuqoaix
URL: https://www.zoores.ac.cn/en/article/doi/10.24272/j.issn.2095-8137.2022.443
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, proteomic and phosphoproteomic profiling, lung and liver pathology, primates
Summary of Study: Proteomic and phosphoproteomic profiling of SARS-CoV-2-infected lung and liver tissues showed potentially active protein synthesis and processing, and dysregulated ECM, cell-to-cell junction, and cytoskeleton but no fibrosis in both the infected lung and liver.
References: PMID: 35091530 / doi: 10.1038/s41392-022-00882-7
Contact Info: Shaui-Yao Lu: [email protected]
URL: https://www.nature.com/articles/s41392-022-00882-7
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, proteomic and phosphoproteomic profiling, lung and liver pathology, primates
Summary of Study: Proteomic and phosphoproteomic profiling of SARS-CoV-2-infected lung and liver tissues showed potentially active protein synthesis and processing, and dysregulated ECM, cell-to-cell junction, and cytoskeleton but no fibrosis in both the infected lung and liver.
References: PMID: 35091530 / doi: 10.1038/s41392-022-00882-7
Contact Info: Shaui-Yao Lu: [email protected]
URL: https://www.nature.com/articles/s41392-022-00882-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Institute of Biological Products; Chinese Academy of Medicine Sciences & Peking Union Medical College
Keywords: SARS-CoV-2, recombinant protein subunit vaccine and an inactivated vaccine, virus variants, primates
Summary of Study: Both vaccines evaluated in this study significantly reduced the viral load in the respiratory tract, alleviated pathological changes, and relieved lung inflammation in vaccinated macaques. The possible contribution of antibodies possessing neutralizing reactivity or cell-mediated cytotoxicity and immune memory to vaccine induced protection was also highlighted.
References: PMID: 35241645 / doi: 10.1038/s41392-022-00926-y
Contact Info: Junzhi Wang: [email protected]
URL: https://www.nature.com/articles/s41392-022-00926-y
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Institute of Biological Products; Chinese Academy of Medicine Sciences & Peking Union Medical College
Keywords: SARS-CoV-2, recombinant protein subunit vaccine and an inactivated vaccine, virus variants, primates
Summary of Study: Both vaccines evaluated in this study significantly reduced the viral load in the respiratory tract, alleviated pathological changes, and relieved lung inflammation in vaccinated macaques. The possible contribution of antibodies possessing neutralizing reactivity or cell-mediated cytotoxicity and immune memory to vaccine induced protection was also highlighted.
References: PMID: 35241645 / doi: 10.1038/s41392-022-00926-y
Contact Info: Junzhi Wang: [email protected]
URL: https://www.nature.com/articles/s41392-022-00926-y
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Tulane National Primate Research Center
Keywords: SARS-CoV-2, noncompeting antibody cocktail, vaccine, immune response, primates
Summary of Study: A neutralizing mAB cocktail with extended half-life can be delivered intramuscularly to provide prophylactic protection against infection in rhesus macaques.
References: PMID: 35291730 / doi: 10.1016/j.medj.2022.02.004
Contact Info: Jay Rappaport: [email protected]
URL: https://www.cell.com/med/fulltext/S2666-6340(22)00087-3?_returnURL=https%3A//li…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Tulane National Primate Research Center
Keywords: SARS-CoV-2, noncompeting antibody cocktail, vaccine, immune response, primates
Summary of Study: A neutralizing mAB cocktail with extended half-life can be delivered intramuscularly to provide prophylactic protection against infection in rhesus macaques.
References: PMID: 35291730 / doi: 10.1016/j.medj.2022.02.004
Contact Info: Jay Rappaport: [email protected]
URL: https://www.cell.com/med/fulltext/S2666-6340(22)00087-3?_returnURL=https%3A//li…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Bavarian Nordic GmbH; Biomedical Primate Research Centre; Aarhus University; University of Copenhagen; AdaptVac Aps
Keywords: SARS-CoV-2, capsid virus-like particle-based vaccine ABNCoV2, immunogenicity, primates
Summary of Study: ABNCoV2 induced strong and long-lasting neutralizing antibody responses and efficacy against SARS-CoV-2 in NHP.
References: PMID: 35479095 / doi: 10.3389/fimmu.2022.857440
Contact Info: Ariane Volkmann: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.857440/full
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Bavarian Nordic GmbH; Biomedical Primate Research Centre; Aarhus University; University of Copenhagen; AdaptVac Aps
Keywords: SARS-CoV-2, capsid virus-like particle-based vaccine ABNCoV2, immunogenicity, primates
Summary of Study: ABNCoV2 induced strong and long-lasting neutralizing antibody responses and efficacy against SARS-CoV-2 in NHP.
References: PMID: 35479095 / doi: 10.3389/fimmu.2022.857440
Contact Info: Ariane Volkmann: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.857440/full
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Institute Pasteur; Universite Paris Saclay-INSERM; Beth Israel Deaconess Medical Center
Keywords: SARS-CoV-2, NK cells, macrophages, blood and bronchoalveolar lavage, immune response, primates
Summary of Study: Viral antigen is found in alveolar macrophages up to at least 18 months after SARS-CoV-2 infection in macaques. Additionally, an association was revealed between lower level of persisting viral antigen in alveolar macrophages and the activity of Spike-specific adaptive NH cells in the lung.
References: PMID: 35547853 / doi: 12.21203/rs.3.rs-1561222/v1
Contact Info: Nicolas Huot: [email protected]
URL: https://www.researchsquare.com/article/rs-1561222/v1
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Institute Pasteur; Universite Paris Saclay-INSERM; Beth Israel Deaconess Medical Center
Keywords: SARS-CoV-2, NK cells, macrophages, blood and bronchoalveolar lavage, immune response, primates
Summary of Study: Viral antigen is found in alveolar macrophages up to at least 18 months after SARS-CoV-2 infection in macaques. Additionally, an association was revealed between lower level of persisting viral antigen in alveolar macrophages and the activity of Spike-specific adaptive NH cells in the lung.
References: PMID: 35547853 / doi: 12.21203/rs.3.rs-1561222/v1
Contact Info: Nicolas Huot: [email protected]
URL: https://www.researchsquare.com/article/rs-1561222/v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: National Rodent Laboratory Animal Resources Center; School of Basic Medical Sciences, Peking University Health Science Center; Northwest University; National Institutes for Food and Drug Control
Keywords: SARS-CoV-2, review, preclinical models, several animal species, primates
Summary of Study: Current animal models for COVID-19 have limitations, and novel models must be developed to truly evaluate the virulence of variants and comorbidities. Proposed model improvements include the use of transgenes or knock-ins to create multiple gene combinations, or reselecting receptor genes.
References: PMID: 35798699 / doi: 10.1038/s41392-022-01087-8
Contact Info: Youchun Wang: [email protected]
URL: https://www.nature.com/articles/s41392-022-01087-8
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: National Rodent Laboratory Animal Resources Center; School of Basic Medical Sciences, Peking University Health Science Center; Northwest University; National Institutes for Food and Drug Control
Keywords: SARS-CoV-2, review, preclinical models, several animal species, primates
Summary of Study: Current animal models for COVID-19 have limitations, and novel models must be developed to truly evaluate the virulence of variants and comorbidities. Proposed model improvements include the use of transgenes or knock-ins to create multiple gene combinations, or reselecting receptor genes.
References: PMID: 35798699 / doi: 10.1038/s41392-022-01087-8
Contact Info: Youchun Wang: [email protected]
URL: https://www.nature.com/articles/s41392-022-01087-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: National Institutes for Food and Drug Control, Beijing; Chinese Academy of Medicine Sciences & Peking Union Medical College; Guangzhou Laboratory; Kunming National High-level Biosafety Primate Research Center
Keywords: SARS-CoV-2, virus variants, virulence, pathogenesis, immune response, primates
Summary of Study: Pathogenic differences of ancestral SARS-CoV-2 strain and a beta variant found the variant resulted in more severe lung injury and an elevated level of inflammatory cytokines, but a lower transmission ability.
References: PMID: 36069561 / doi: 10.1128/spectrum.02263-22
Contact Info: Junzhi Wang: [email protected]; Miao Xu: [email protected]
URL: https://journals.asm.org/doi/full/10.1128/spectrum.02263-22?rfr_dat=cr_pub%20%2…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: National Institutes for Food and Drug Control, Beijing; Chinese Academy of Medicine Sciences & Peking Union Medical College; Guangzhou Laboratory; Kunming National High-level Biosafety Primate Research Center
Keywords: SARS-CoV-2, virus variants, virulence, pathogenesis, immune response, primates
Summary of Study: Pathogenic differences of ancestral SARS-CoV-2 strain and a beta variant found the variant resulted in more severe lung injury and an elevated level of inflammatory cytokines, but a lower transmission ability.
References: PMID: 36069561 / doi: 10.1128/spectrum.02263-22
Contact Info: Junzhi Wang: [email protected]; Miao Xu: [email protected]
URL: https://journals.asm.org/doi/full/10.1128/spectrum.02263-22?rfr_dat=cr_pub%20%2…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Merck & Co., Inc., Rahway, NJ, USA; Certara, Princeton, NJ, USA
Keywords: SARS-CoV-2, vaccine, meta-analysis, preclinical and clinical data, immunogenicity, primates
Summary of Study: Development and application of a model-based meta-analysis (MBMA) approach integrating non-clinical and clinical immunogenicity and protection data.
References: doi: 10.1016/j.ebiom.2022.104264
Contact Info: Bhargava Kandala: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2352396422004467?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Merck & Co., Inc., Rahway, NJ, USA; Certara, Princeton, NJ, USA
Keywords: SARS-CoV-2, vaccine, meta-analysis, preclinical and clinical data, immunogenicity, primates
Summary of Study: Development and application of a model-based meta-analysis (MBMA) approach integrating non-clinical and clinical immunogenicity and protection data.
References: doi: 10.1016/j.ebiom.2022.104264
Contact Info: Bhargava Kandala: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2352396422004467?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID RNA Viruses Section, Laboratory of Infectious Diseases, numerous others
Keywords: SARS-CoV-2, pediatric vaccine, live-attenuated parainfluenza-virus-vectored vaccine, immunogenicity, primates
Summary of Study: Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine is protective in monkeys
References: doi: 10.1016/j.cell.2022.11.006
Contact Info: Ursula Buchholz: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0092867422014180?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: NIAID RNA Viruses Section, Laboratory of Infectious Diseases, numerous others
Keywords: SARS-CoV-2, pediatric vaccine, live-attenuated parainfluenza-virus-vectored vaccine, immunogenicity, primates
Summary of Study: Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine is protective in monkeys
References: doi: 10.1016/j.cell.2022.11.006
Contact Info: Ursula Buchholz: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0092867422014180?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shanghai Medical College, Fudan University; Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College; the First Affiliated Hospital of Guangzhou Medical University; Guangzhou Eighth People's Hospital of Guangzhou Medical University; Bio-Island; Graduate School of Peking Union Medical College; NIFDC; Fulgent Pharma LLC
Keywords: SARS-CoV-2, pan-sarbecovirus vaccines, STING agonist CF501, virus variants, immune response, mice, rabbits, primates.
Summary of Study: A pan-sarbecovirus vaccine was designed by using human IgG Fc-conjugated RBD from the original SARS-CoV-2 strain as the vaccine's immunogen and the STING agonist CF501 as the vaccine's adjuvant. This CF501/RBD-Fc vaccine candidate was able to induce extremely potent, durable, and broad-spectrum nAb and T cell responses, as well as protective immunity, suggesting its potential for development as a highly potent and durable pan-sarbecovirus vaccine.
References: PMID: 35046518 / doi: 10.1038/s41422-022-00612-2
Contact Info: Youchun Wang: [email protected]; Yilong Zhang: [email protected]; Jincun Zhao: [email protected]
URL: https://www.nature.com/articles/s41422-022-00612-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shanghai Medical College, Fudan University; Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College; the First Affiliated Hospital of Guangzhou Medical University; Guangzhou Eighth People's Hospital of Guangzhou Medical University; Bio-Island; Graduate School of Peking Union Medical College; NIFDC; Fulgent Pharma LLC
Keywords: SARS-CoV-2, pan-sarbecovirus vaccines, STING agonist CF501, virus variants, immune response, mice, rabbits, primates.
Summary of Study: A pan-sarbecovirus vaccine was designed by using human IgG Fc-conjugated RBD from the original SARS-CoV-2 strain as the vaccine's immunogen and the STING agonist CF501 as the vaccine's adjuvant. This CF501/RBD-Fc vaccine candidate was able to induce extremely potent, durable, and broad-spectrum nAb and T cell responses, as well as protective immunity, suggesting its potential for development as a highly potent and durable pan-sarbecovirus vaccine.
References: PMID: 35046518 / doi: 10.1038/s41422-022-00612-2
Contact Info: Youchun Wang: [email protected]; Yilong Zhang: [email protected]; Jincun Zhao: [email protected]
URL: https://www.nature.com/articles/s41422-022-00612-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Washington; Washington National Primate Research Center; HDT Bio
Keywords: SARS-CoV-2, immunocompromised animals, SIV, RNA vaccine, immunogenicity, primates
Summary of Study: SARS-CoV-2 alphavirus-derived replicon RNA vaccine formulated with a novel Lipid InOrganic Nanoparticle (LION) emulsion (repRNA-CoV2S) induced robust cellular and humoral immune responses after a single immunization in immunocompromised SIV-infected animals as a highly relevant model of untreated HIV infection in humans.
References: PMID: 34992610 / doi: 10.3389/fimmu.2021.800723
Contact Info: Deborah Fuller: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.800723/full
NHP Species: pigtail macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: University of Washington; Washington National Primate Research Center; HDT Bio
Keywords: SARS-CoV-2, immunocompromised animals, SIV, RNA vaccine, immunogenicity, primates
Summary of Study: SARS-CoV-2 alphavirus-derived replicon RNA vaccine formulated with a novel Lipid InOrganic Nanoparticle (LION) emulsion (repRNA-CoV2S) induced robust cellular and humoral immune responses after a single immunization in immunocompromised SIV-infected animals as a highly relevant model of untreated HIV infection in humans.
References: PMID: 34992610 / doi: 10.3389/fimmu.2021.800723
Contact Info: Deborah Fuller: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.800723/full
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: diagnostics
NPRC/Institute: Universite Paris-Saclay, Inserm, CEA; Sorbonne Universite; BioPredictive; Institut Pasteur
Keywords: SARS-CoV-2, blood test, diagnostics, primates
Summary of Study: Results validate the diagnostic and prognostic performances of A1HPV6 in patients infected by SARS-CoV-2, not hospitalized in ICU. These results are reinforced by similar kinetics of A1, HP, and A2M observed in the macaque model.
References: PMID: 35174366 / doi: 10.1016/j.gastha.2021.12.009
Contact Info: Thierry Poynard: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818442/
NHP Species:
Year Published: 2022
Study Type/Review: diagnostics
NPRC/Institute: Universite Paris-Saclay, Inserm, CEA; Sorbonne Universite; BioPredictive; Institut Pasteur
Keywords: SARS-CoV-2, blood test, diagnostics, primates
Summary of Study: Results validate the diagnostic and prognostic performances of A1HPV6 in patients infected by SARS-CoV-2, not hospitalized in ICU. These results are reinforced by similar kinetics of A1, HP, and A2M observed in the macaque model.
References: PMID: 35174366 / doi: 10.1016/j.gastha.2021.12.009
Contact Info: Thierry Poynard: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818442/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: California National Primate Research Center; University of California, Davis; Vitalant Research Institute; University of Colorado School of Medicine; University of California, Irvine; University of California, San Francisco
Keywords: SARS-CoV-2, human convalescent plasma, inflammation, primates
Summary of Study: Administration of CCP had minimal effects on reducing virus replication in the respiratory tract, but it significantly reduced lung inflammation. These data, combined with the results of monoclonal antibody studies, emphasize the need to use products with high titers of neutralizing antibodies, and guide the future development of antibody-based therapies.
References: PMID: 35443018 / doi: 10.1371/journal.ppat.1009925
Contact Info: Koen Van Rompay: [email protected]; Michael Busch: [email protected]; Rachel Reader: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009925
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: California National Primate Research Center; University of California, Davis; Vitalant Research Institute; University of Colorado School of Medicine; University of California, Irvine; University of California, San Francisco
Keywords: SARS-CoV-2, human convalescent plasma, inflammation, primates
Summary of Study: Administration of CCP had minimal effects on reducing virus replication in the respiratory tract, but it significantly reduced lung inflammation. These data, combined with the results of monoclonal antibody studies, emphasize the need to use products with high titers of neutralizing antibodies, and guide the future development of antibody-based therapies.
References: PMID: 35443018 / doi: 10.1371/journal.ppat.1009925
Contact Info: Koen Van Rompay: [email protected]; Michael Busch: [email protected]; Rachel Reader: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009925
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Sun Yat-sen University; The First Affiliated Hospital of Guangzhou Medical University; Southern University of Science and Technology; The First Affiliated Hospital of Sun Yat-sen University; Guangdong Provincial Center for Disease Control and Prevention; Guangdong-Hong Kong Joint Laboratory for RNA Medicine
Keywords: SARS-CoV-2, quadrivalent mosaic HexaPro-bearing nanoparticle vaccine, virus variants, mice and primates
Summary of Study: A quadrivalent mosaic nanoparticle vaccine displaying spike proteins from the SARS-CoV-2 prototype and 3 different VOCs elicits equivalent or superior neutralizing antibodies against variant strains in mice and non-human primates with only small reduction in neutralization titers against the ancestral strain.
References: PMID: 35562337 / doi: 10.1038/s41467-022-30222-w
Contact Info: Jin-Cun Zhao: [email protected]; Run-Yu Yuan: [email protected]; Mu-Sheng Zeng: [email protected]
URL: https://www.nature.com/articles/s41467-022-30222-w
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Sun Yat-sen University; The First Affiliated Hospital of Guangzhou Medical University; Southern University of Science and Technology; The First Affiliated Hospital of Sun Yat-sen University; Guangdong Provincial Center for Disease Control and Prevention; Guangdong-Hong Kong Joint Laboratory for RNA Medicine
Keywords: SARS-CoV-2, quadrivalent mosaic HexaPro-bearing nanoparticle vaccine, virus variants, mice and primates
Summary of Study: A quadrivalent mosaic nanoparticle vaccine displaying spike proteins from the SARS-CoV-2 prototype and 3 different VOCs elicits equivalent or superior neutralizing antibodies against variant strains in mice and non-human primates with only small reduction in neutralization titers against the ancestral strain.
References: PMID: 35562337 / doi: 10.1038/s41467-022-30222-w
Contact Info: Jin-Cun Zhao: [email protected]; Run-Yu Yuan: [email protected]; Mu-Sheng Zeng: [email protected]
URL: https://www.nature.com/articles/s41467-022-30222-w
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: GigaGen, Inc.; Alira Health, Inc.; Grifols S.A.; Vitalant Research Institute; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, drugs, GMP, clinical manufacturing, therapy, mice, primates
Summary of Study: A novel class of drugs, recombinant hyperimmune globulins are a safe and protective possible treatment to COVID-19 that could be made through large-scale production.
References: PMID: 35890050 / doi: 10.3390/pathogens11070806
Contact Info: Adam Adler: [email protected]
URL: https://www.mdpi.com/2076-0817/11/7/806
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: GigaGen, Inc.; Alira Health, Inc.; Grifols S.A.; Vitalant Research Institute; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, drugs, GMP, clinical manufacturing, therapy, mice, primates
Summary of Study: A novel class of drugs, recombinant hyperimmune globulins are a safe and protective possible treatment to COVID-19 that could be made through large-scale production.
References: PMID: 35890050 / doi: 10.3390/pathogens11070806
Contact Info: Adam Adler: [email protected]
URL: https://www.mdpi.com/2076-0817/11/7/806
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Research Institute for Biological Safety Problems, Kazakhstan
Keywords: SARS-CoV-2, inactivated vaccine, safety, immune response, several animal species, primates
Summary of Study: The first COVID-19 inactivated vaccine developed in Kazakhstan did not result in any adverse effect or change in condition of the animals' health, has high immunogenic potential, and is safe to move to clinical research.
References: PMID: 35960911 / doi: 10.1080/21645515.2022.2087412
Contact Info: Zhandos Abay: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/21645515.2022.2087412
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Research Institute for Biological Safety Problems, Kazakhstan
Keywords: SARS-CoV-2, inactivated vaccine, safety, immune response, several animal species, primates
Summary of Study: The first COVID-19 inactivated vaccine developed in Kazakhstan did not result in any adverse effect or change in condition of the animals' health, has high immunogenic potential, and is safe to move to clinical research.
References: PMID: 35960911 / doi: 10.1080/21645515.2022.2087412
Contact Info: Zhandos Abay: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/21645515.2022.2087412
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA; numerous others
Keywords: SARS-CoV-2, vaccine, Ad26.COV2.S, spike ferritin nanoparticles, immune response, primates
Summary of Study: Protection against SARS-CoV-2 Omicron BA.1 variant challenge
References: doi: 10.1126/sciadv.ade4433
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.ade4433
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA; numerous others
Keywords: SARS-CoV-2, vaccine, Ad26.COV2.S, spike ferritin nanoparticles, immune response, primates
Summary of Study: Protection against SARS-CoV-2 Omicron BA.1 variant challenge
References: doi: 10.1126/sciadv.ade4433
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.ade4433
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: MIT; Broad Institute of MIT and Harvard; Ragan Institute of MGH, MIT, and Harvard; University of Duisburg-Essen; Space Exploration Technologies Corp.; Harvard University; Vanderbilt University Medical Center; Northwestern University Feinberg School of Medicine; University of Bonn; Howard Hughes Medical Institute; Massachusetts Consortium on Pathogen Readiness; Harvard Medical School; Brigham and Womoen's Hospital; Harvard Humanitarian Initiative
Keywords: SARS-CoV-2, immune biomarkers, reinfection, immune response, primates
Summary of Study: A specific set of SARS-CoV-2-specific humoral features, including spike RBD-specific IgG1 titers, nucleocapsid-specific IgG3 titers, and anti-spike RBD FcyR2A binding activity, were identified as robust biomarkers of reinfection that translate across species. When reinfection cannot be confirmed by viral sequence, changes in SARS-CoV-2 humoral immune responses may offer inexpensive, reliable, and effective measures to track reinfection.
References: PMID: 35073738 / doi: 10.1128/mbio.02141-21
Contact Info: Douglas Lauffenburger: [email protected]; Galit Alter: [email protected]
URL: https://journals.asm.org/doi/full/10.1128/mbio.02141-21?rfr_dat=cr_pub%20%200pu…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: MIT; Broad Institute of MIT and Harvard; Ragan Institute of MGH, MIT, and Harvard; University of Duisburg-Essen; Space Exploration Technologies Corp.; Harvard University; Vanderbilt University Medical Center; Northwestern University Feinberg School of Medicine; University of Bonn; Howard Hughes Medical Institute; Massachusetts Consortium on Pathogen Readiness; Harvard Medical School; Brigham and Womoen's Hospital; Harvard Humanitarian Initiative
Keywords: SARS-CoV-2, immune biomarkers, reinfection, immune response, primates
Summary of Study: A specific set of SARS-CoV-2-specific humoral features, including spike RBD-specific IgG1 titers, nucleocapsid-specific IgG3 titers, and anti-spike RBD FcyR2A binding activity, were identified as robust biomarkers of reinfection that translate across species. When reinfection cannot be confirmed by viral sequence, changes in SARS-CoV-2 humoral immune responses may offer inexpensive, reliable, and effective measures to track reinfection.
References: PMID: 35073738 / doi: 10.1128/mbio.02141-21
Contact Info: Douglas Lauffenburger: [email protected]; Galit Alter: [email protected]
URL: https://journals.asm.org/doi/full/10.1128/mbio.02141-21?rfr_dat=cr_pub%20%200pu…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; China Agricultural University; Capital Medical University; University of Science & Technology of China; Chinese Academy of Medical Sciences and Peking Union Medical College; Chinese Center for Disease Control and Prevention
Keywords: SARS-CoV-2, human neutralizing antibodies, virus variants, mice, primates
Summary of Study: bsAB15 was developed and shown to efficiently neutralize all single-mAb escape mutants. This bsAb is a feasible and effective strategy to treat and prevent severe COVID-19.
References: PMID: 35228696 / doi: 10.1038/s41590-022-01138-w
Contact Info: Yan Wu: [email protected]; Feng Gao: [email protected]
URL: https://www.nature.com/articles/s41590-022-01138-w
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; China Agricultural University; Capital Medical University; University of Science & Technology of China; Chinese Academy of Medical Sciences and Peking Union Medical College; Chinese Center for Disease Control and Prevention
Keywords: SARS-CoV-2, human neutralizing antibodies, virus variants, mice, primates
Summary of Study: bsAB15 was developed and shown to efficiently neutralize all single-mAb escape mutants. This bsAb is a feasible and effective strategy to treat and prevent severe COVID-19.
References: PMID: 35228696 / doi: 10.1038/s41590-022-01138-w
Contact Info: Yan Wu: [email protected]; Feng Gao: [email protected]
URL: https://www.nature.com/articles/s41590-022-01138-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; University of California, San Diego; University of Cape Town, Observatory, South Africa
Keywords: SARS-CoV-2, mild infection, pathology, immune response, primates
Summary of Study: SARS-CoV-2 replication wanes in the lungs, as well as the nasal and oral mucosa, of rhesus macaques before antigen-specific effector T cells arrive at those sites, suggesting that innate immunity efficiently restricts viral replication during mild COVID-19.
References: PMID: 35271298 / doi: 10.1126/sciimmunol.abo0535
Contact Info: Daniel Barber: [email protected]
URL: https://www.science.org/doi/full/10.1126/sciimmunol.abo0535?rfr_dat=cr_pub%20%2…
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: NIAID; University of California, San Diego; University of Cape Town, Observatory, South Africa
Keywords: SARS-CoV-2, mild infection, pathology, immune response, primates
Summary of Study: SARS-CoV-2 replication wanes in the lungs, as well as the nasal and oral mucosa, of rhesus macaques before antigen-specific effector T cells arrive at those sites, suggesting that innate immunity efficiently restricts viral replication during mild COVID-19.
References: PMID: 35271298 / doi: 10.1126/sciimmunol.abo0535
Contact Info: Daniel Barber: [email protected]
URL: https://www.science.org/doi/full/10.1126/sciimmunol.abo0535?rfr_dat=cr_pub%20%2…
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine; Tulane National Primate Research Center
Keywords: SARS-CoV-2, neuropathogenesis, primates
Summary of Study: Substantial pathological changes in brains of SARS-CoV-2 infected NHPs are compatible with autopsy and imaging reports of infected human subjects.
References: PMID: 35365631 / doi: 10.1038/s41467-022-29440-z
Contact Info: Tracy Fischer: [email protected]
URL: https://www.nature.com/articles/s41467-022-29440-z
NHP Species: african green monkeys, rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine; Tulane National Primate Research Center
Keywords: SARS-CoV-2, neuropathogenesis, primates
Summary of Study: Substantial pathological changes in brains of SARS-CoV-2 infected NHPs are compatible with autopsy and imaging reports of infected human subjects.
References: PMID: 35365631 / doi: 10.1038/s41467-022-29440-z
Contact Info: Tracy Fischer: [email protected]
URL: https://www.nature.com/articles/s41467-022-29440-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, protocols, animal models, immunology, primates
Summary of Study: This book describes the different aspects of modelling the SARS-CoV-2 infection in NHPs along with the associated methods used in immunology.
References: PMID: 35554911 / doi. 10.1007/978-1-2111-0_15
Contact Info: Deepak Kaushal: [email protected]
URL: https://link.springer.com/protocol/10.1007/978-1-0716-2111-0_15
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center; Texas Biomedical Research Institute
Keywords: SARS-CoV-2, protocols, animal models, immunology, primates
Summary of Study: This book describes the different aspects of modelling the SARS-CoV-2 infection in NHPs along with the associated methods used in immunology.
References: PMID: 35554911 / doi. 10.1007/978-1-2111-0_15
Contact Info: Deepak Kaushal: [email protected]
URL: https://link.springer.com/protocol/10.1007/978-1-0716-2111-0_15
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Institute of Zoonosis, and College of Veterinary Medicine, Jilin University; Chinese Academy of Medicine Sciences & Peking Union Medical College; Walvax Biotechnology Co., Ltd; Inner Mongolia University for Nationalities; Chinese Academy of Agricultural Sciences; Yuxi JOZO Biotechnology co., LTD; Tongji Medical College, Huazhong University of Science and Technology
Keywords: SARS-CoV-2, equine immunoglobulin, anti virus efficacy, histopathology, immune response, primates
Summary of Study: Therapeutic-grade equine immunoglobins are effective at improving the clinical symptoms of those hospitalized with SARS-CoV-2 and can be rapidly developed.
References: PMID: 35798694 / doi: 10.1038/s41392-022-01095-8
Contact Info: Zhongping Xie: [email protected]; Ningyi Jin: [email protected]; Mingyuan Liu: [email protected]
URL: https://www.nature.com/articles/s41392-022-01095-8
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review:
NPRC/Institute: Institute of Zoonosis, and College of Veterinary Medicine, Jilin University; Chinese Academy of Medicine Sciences & Peking Union Medical College; Walvax Biotechnology Co., Ltd; Inner Mongolia University for Nationalities; Chinese Academy of Agricultural Sciences; Yuxi JOZO Biotechnology co., LTD; Tongji Medical College, Huazhong University of Science and Technology
Keywords: SARS-CoV-2, equine immunoglobulin, anti virus efficacy, histopathology, immune response, primates
Summary of Study: Therapeutic-grade equine immunoglobins are effective at improving the clinical symptoms of those hospitalized with SARS-CoV-2 and can be rapidly developed.
References: PMID: 35798694 / doi: 10.1038/s41392-022-01095-8
Contact Info: Zhongping Xie: [email protected]; Ningyi Jin: [email protected]; Mingyuan Liu: [email protected]
URL: https://www.nature.com/articles/s41392-022-01095-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Saskatchewan; Dalhousie University; University of Pittsburgh
Keywords: SARS-CoV-2, review, post-acute sequelae, pathology, immune response, several animal species, primates
Summary of Study: Analysis of work done in different animal models in order to understand the mechanisms of Long COVID that could help identify treatments.
References: PMID: 36070309 / doi: 10.1371/journal.ppat.1010741
Contact Info: Alyson A. Kelvin: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010741
NHP Species: rhesus macaques, african green monkeys
Year Published: 2022
Study Type/Review:
NPRC/Institute: University of Saskatchewan; Dalhousie University; University of Pittsburgh
Keywords: SARS-CoV-2, review, post-acute sequelae, pathology, immune response, several animal species, primates
Summary of Study: Analysis of work done in different animal models in order to understand the mechanisms of Long COVID that could help identify treatments.
References: PMID: 36070309 / doi: 10.1371/journal.ppat.1010741
Contact Info: Alyson A. Kelvin: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010741
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China; National Center of Technology Innovation for Animal Model, Beijing, China.
Keywords: SARS-CoV-2, review, animal model resources, comparative analysis, several animal species, primates
Summary of Study: Characterization of animal model resources
References: doi: 10.1002/ame2.12278
Contact Info: Chuan Qin: nc.ude.cmup@nauhcniq
URL: https://onlinelibrary.wiley.com/doi/full/10.1002/ame2.12278
NHP Species: multiple species
Year Published: 2022
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China; National Center of Technology Innovation for Animal Model, Beijing, China.
Keywords: SARS-CoV-2, review, animal model resources, comparative analysis, several animal species, primates
Summary of Study: Characterization of animal model resources
References: doi: 10.1002/ame2.12278
Contact Info: Chuan Qin: nc.ude.cmup@nauhcniq
URL: https://onlinelibrary.wiley.com/doi/full/10.1002/ame2.12278
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shanghai Zerun Biotech Co., Ltd.; numerous others
Keywords: SARS-CoV-2, recombinant vaccine, immunogenicity, virus variants, hamster, primates
Summary of Study: A potent, broadly protective vaccine against SARS-CoV-2 variants of concern.
References: doi: 10.1038/s41541-022-00571-0
Contact Info: Chenliang Zhou: [email protected]
URL: https://www.nature.com/articles/s41541-022-00571-0
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Shanghai Zerun Biotech Co., Ltd.; numerous others
Keywords: SARS-CoV-2, recombinant vaccine, immunogenicity, virus variants, hamster, primates
Summary of Study: A potent, broadly protective vaccine against SARS-CoV-2 variants of concern.
References: doi: 10.1038/s41541-022-00571-0
Contact Info: Chenliang Zhou: [email protected]
URL: https://www.nature.com/articles/s41541-022-00571-0
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Emergent BioSolutions; Yoh Services LLC; Sanofi Pasteur; Translate Bio; UT Health Science Center at Houston
Keywords: SARS-CoV-2, virus variants, vaccine, boost, neutralizing effects, primates
Summary of Study: This study showed that a third vaccination administered as a booster, regardless of composition, to the currently approved two dose regimens could effectively promote broadly neutralizing antibodies against all variants of concern.
References: PMID: 35101265 / doi: 10.1016/j.vaccine.2022.01.021
Contact Info: Natalie Anosova: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22000457?via%3Dihub=
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Emergent BioSolutions; Yoh Services LLC; Sanofi Pasteur; Translate Bio; UT Health Science Center at Houston
Keywords: SARS-CoV-2, virus variants, vaccine, boost, neutralizing effects, primates
Summary of Study: This study showed that a third vaccination administered as a booster, regardless of composition, to the currently approved two dose regimens could effectively promote broadly neutralizing antibodies against all variants of concern.
References: PMID: 35101265 / doi: 10.1016/j.vaccine.2022.01.021
Contact Info: Natalie Anosova: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X22000457?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: China Pharmaceutical University; Yunnan Walvax Biotech
Keywords: SARS-CoV-2, chimpanzee adenovirus-based vaccine, immunogenicity, toxicology, rats, primates
Summary of Study: AdC68-19S, a recombinant chimpanzee adenovirus serotype 68 vector-based vaccine encoding the full-length spike protein of SARS-CoV-2, induced an effective immune response with a good safety profile in rhesus macaques.
References: PMID: 35226134 / doi: 10.1007/s00204-021-03221-x
Contact Info: Zhen Huang: [email protected]
URL: https://link.springer.com/article/10.1007/s00204-021-03221-x
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: China Pharmaceutical University; Yunnan Walvax Biotech
Keywords: SARS-CoV-2, chimpanzee adenovirus-based vaccine, immunogenicity, toxicology, rats, primates
Summary of Study: AdC68-19S, a recombinant chimpanzee adenovirus serotype 68 vector-based vaccine encoding the full-length spike protein of SARS-CoV-2, induced an effective immune response with a good safety profile in rhesus macaques.
References: PMID: 35226134 / doi: 10.1007/s00204-021-03221-x
Contact Info: Zhen Huang: [email protected]
URL: https://link.springer.com/article/10.1007/s00204-021-03221-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beijing Institute of Microbiology and Epidemiology; Sinocelltech, Ltd.; Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, polysaccharide–protein-conjugated nanoparticle vaccine, virus variants, mice, rats, primates
Summary of Study: A novel nanoparticle vaccine was designed and prepared by chemically conjugating recombinant SARD-CoV-2 RBD and PPS14. Studies have demonstrated that SCTV01B vaccination induced potent and broad neutralizing antibodies and cellular immune responses against SARS-CoV-2 in mice, rats, and nonhuman primates, as well as high OPA against S. pneumoniae serotype 14.
References: PMID: 35332581 / doi: 10.1002/adma.202200443
Contact Info: Liangzhi Xie: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/adma.202200443
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Beijing Institute of Microbiology and Epidemiology; Sinocelltech, Ltd.; Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, polysaccharide–protein-conjugated nanoparticle vaccine, virus variants, mice, rats, primates
Summary of Study: A novel nanoparticle vaccine was designed and prepared by chemically conjugating recombinant SARD-CoV-2 RBD and PPS14. Studies have demonstrated that SCTV01B vaccination induced potent and broad neutralizing antibodies and cellular immune responses against SARS-CoV-2 in mice, rats, and nonhuman primates, as well as high OPA against S. pneumoniae serotype 14.
References: PMID: 35332581 / doi: 10.1002/adma.202200443
Contact Info: Liangzhi Xie: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/adma.202200443
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Peking Union Medical College; National Center of Technology Innovation for Animal Model; Chinese Academy of Sciences; Capital Medical University
Keywords: SARS-CoV-2, inactivated vaccine, booster, immune response, virus variants, primates
Summary of Study: Animals administered with an indicated booster dose and subsequently challenged with Delta or Omicron variants showed markedly reduced viral loads and improved histopathological profiles compared to control animals, indicating that sequential immunization could protect primates against Omicron.
References: PMID: 35436986 / doi: 10.1038/s41392-022-00979-z
Contact Info: Chuan Qin: [email protected];
URL: https://www.nature.com/articles/s41392-022-00979-z
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Peking Union Medical College; National Center of Technology Innovation for Animal Model; Chinese Academy of Sciences; Capital Medical University
Keywords: SARS-CoV-2, inactivated vaccine, booster, immune response, virus variants, primates
Summary of Study: Animals administered with an indicated booster dose and subsequently challenged with Delta or Omicron variants showed markedly reduced viral loads and improved histopathological profiles compared to control animals, indicating that sequential immunization could protect primates against Omicron.
References: PMID: 35436986 / doi: 10.1038/s41392-022-00979-z
Contact Info: Chuan Qin: [email protected];
URL: https://www.nature.com/articles/s41392-022-00979-z
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: The Broad Institute of Harvard and MIT; Harvard University; Universite Paris-Saclay, Inserm, CEA; Genethon INTEGRARE UMR; Rega Institute; University of Siena; University of Pennsylvania
Keywords: SARS-CoV-2, AAV-based vaccine, virus variants, immune response, mice, primates
Summary of Study: AAV-based vaccines for COVID-19 can be effective from a single, low dose and lead to durable humoral and strong T cell immunogenicity.
References: PMID: 35546782 / doi: 10.1016/j.ymthe.2022.05.007
Contact Info: Luk Vandenberghe: [email protected]
URL: https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-…
NHP Species:
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: The Broad Institute of Harvard and MIT; Harvard University; Universite Paris-Saclay, Inserm, CEA; Genethon INTEGRARE UMR; Rega Institute; University of Siena; University of Pennsylvania
Keywords: SARS-CoV-2, AAV-based vaccine, virus variants, immune response, mice, primates
Summary of Study: AAV-based vaccines for COVID-19 can be effective from a single, low dose and lead to durable humoral and strong T cell immunogenicity.
References: PMID: 35546782 / doi: 10.1016/j.ymthe.2022.05.007
Contact Info: Luk Vandenberghe: [email protected]
URL: https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses; Jilin University First Hospital; Beijing Institute of Biotechnology; College of Basic Medical Sciences; Zhongshan Hospital Fudan University; Beijing Institute of Microbiology and Epidemiology; Shaanxi Normal University
Keywords: SARS-CoV-2, proteomics, metabolomics, pathology, immune response, primates
Summary of Study: An established COVID-19 model demonstrates that the innate immune response, neutrophil and platelet activation were dysregulated in infected NHPs, and these were greatly weakened in the most infected NHPs, which models moderately infected humans.
References: PMID: 35903092 / doi: 10.3389/fimmu.2022.954121
Contact Info: Yuwei Gao: [email protected]; Yan Liu: [email protected]; Xiaochang Xue: [email protected]; Hui Wang: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.954121/full
NHP Species:
Year Published: 2022
Study Type/Review:
NPRC/Institute: Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses; Jilin University First Hospital; Beijing Institute of Biotechnology; College of Basic Medical Sciences; Zhongshan Hospital Fudan University; Beijing Institute of Microbiology and Epidemiology; Shaanxi Normal University
Keywords: SARS-CoV-2, proteomics, metabolomics, pathology, immune response, primates
Summary of Study: An established COVID-19 model demonstrates that the innate immune response, neutrophil and platelet activation were dysregulated in infected NHPs, and these were greatly weakened in the most infected NHPs, which models moderately infected humans.
References: PMID: 35903092 / doi: 10.3389/fimmu.2022.954121
Contact Info: Yuwei Gao: [email protected]; Yan Liu: [email protected]; Xiaochang Xue: [email protected]; Hui Wang: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2022.954121/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Betuvax LLC; Lomonosov Moscow State University; Clinical Excellence Group LLC; I.I. Mechnikov North-Western State Medical University; PJSC Human Stem Cells Institute; Center of Genetics and Reproductive Medicine; Sechenov First Moscow State Medical University; Biotechnology Developments LLC; Ministry of Health of the Russian Federation
Keywords: SARS-CoV-2, subunit vaccine, “Betuvax-CoV-2”, preclinical studies, several animal species, primates
Summary of Study: A vaccine developed as a subunit that contains a recombinant receptor-binding domain fusion protein and virus-like nanoparticles demonstrates effective protection through COVID-19 neutralizing antibody production and conferring infection and lung damage protection.
References: PMID: 36016181 / doi: 10.3390/vaccines10081290
Contact Info: Anna Vakrusheva: [email protected]
URL: https://www.mdpi.com/2076-393X/10/8/1290
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Betuvax LLC; Lomonosov Moscow State University; Clinical Excellence Group LLC; I.I. Mechnikov North-Western State Medical University; PJSC Human Stem Cells Institute; Center of Genetics and Reproductive Medicine; Sechenov First Moscow State Medical University; Biotechnology Developments LLC; Ministry of Health of the Russian Federation
Keywords: SARS-CoV-2, subunit vaccine, “Betuvax-CoV-2”, preclinical studies, several animal species, primates
Summary of Study: A vaccine developed as a subunit that contains a recombinant receptor-binding domain fusion protein and virus-like nanoparticles demonstrates effective protection through COVID-19 neutralizing antibody production and conferring infection and lung damage protection.
References: PMID: 36016181 / doi: 10.3390/vaccines10081290
Contact Info: Anna Vakrusheva: [email protected]
URL: https://www.mdpi.com/2076-393X/10/8/1290
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, numerous others
Keywords: SARS-CoV-2, vaccine, BNT162b2, mRNA-1273, infants, immune response, primates
Summary of Study: Protection in immunized infant macaques
References: doi: 10.1126/scitranslmed.add6383
Contact Info: Kristina de Paris: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.add6383
NHP Species: rhesus macaques
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, numerous others
Keywords: SARS-CoV-2, vaccine, BNT162b2, mRNA-1273, infants, immune response, primates
Summary of Study: Protection in immunized infant macaques
References: doi: 10.1126/scitranslmed.add6383
Contact Info: Kristina de Paris: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.add6383
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: City of Hope National Medical Center
Keywords: SARS-CoV-2, synthetic multiantigen modified vaccine, COH04S1, immune response, hamsters, primates
Summary of Study: Vaccine candidate C0H04S1 stimulates protective immunity against SARS-CoV-2 in Syrian hamsters by intramuscular and intranasal vaccination and in non-human primates through two-dose and single-dose regimens.
References: PMID: 35064109 / doi: 10.1038/s41541-022-00436-6
Contact Info: Felix Wussow: [email protected]
URL: https://www.nature.com/articles/s41541-022-00436-6
NHP Species: african green monkeys
Year Published: 2022
Study Type/Review: vaccine
NPRC/Institute: City of Hope National Medical Center
Keywords: SARS-CoV-2, synthetic multiantigen modified vaccine, COH04S1, immune response, hamsters, primates
Summary of Study: Vaccine candidate C0H04S1 stimulates protective immunity against SARS-CoV-2 in Syrian hamsters by intramuscular and intranasal vaccination and in non-human primates through two-dose and single-dose regimens.
References: PMID: 35064109 / doi: 10.1038/s41541-022-00436-6
Contact Info: Felix Wussow: [email protected]
URL: https://www.nature.com/articles/s41541-022-00436-6