Supercomputing Technologies Funded by ORIP Helped Spur Approval of COVID-19 Vaccines and Save Lives*
Supercomputing has been gaining attention for its applications across biomedical research. A type of high-performance computing...
ARRA Funds Enhance Training Opportunities in Neurological Research
Composed of 86 billion neurons and an array of intricate structures, the human brain is a complex organ that regulates every process within the body.
ARRA-Funded Rutgers Repository Pivots to COVID-19 Testing During Pandemic
In 2010, the Rutgers University Cell and DNA Repository (RUCDR) was awarded nearly $10 million (C06RR030323) to renovate space for a core facility offering biological sample storage and repository services.
An Interdisciplinary Team Assembled to Preserve Aquatic Genetic Resources and to Develop Capacity Building at Resource Center Cryo-Repositories
Researchers use a diverse array of aquatic organisms—such as fish, amphibians, and invertebrates—to explore various biological questions.
NIH ARRA Investment Funds State-of-the-Art Core Facility to Support the Future of RNA Medicine at Beth Israel Deaconess Medical Center
Dr. Frank Slack, Director of the Harvard Medical School Initiative for RNA Medicine (HIRM), envisions a promising future for RNA-based therapeutics...
ORIP Support for Small Businesses Leads to New Commercial Technology Outcomes That Benefit Community Resources and Advance Research Discoveries
ORIP participates in two federal grant programs that provide funding to small businesses: the Small Business Innovation Research (SBIR) program and the Small Business Technology Transfer (STTR) program. The primary goal of ORIP’s small business programs is to attract innovative SBIR/STTR projects that could benefit research resources and communities associated with ORIP’s mission.
Mouse Research Yields New Insights on Mendelian Disease Genetics
Gregor Mendel’s work in the 19th century laid the foundation for our current understanding of heritability—the ways in which phenotypes (i.e., an individual’s observable traits) are...
Gnotobiotic Mouse Resources Support Studies of Microbial Interactions
Microorganisms affect nearly every aspect of life, regulating numerous biological processes at the ecosystem and organismal levels. All multi-organ animals maintain a unique gut microbiome that plays a key role in regulation of their metabolic, immune, and neurological functions. This area of research has expanded thanks to studies catalyzed by the NIH Human Microbiome Project, but the functional consequences of microbial changes—and the role of individual bacterial species and combinations—remain unknown.
Reproducibility of Rodent Models for Human Disease: MiniMUGA as a Critical Genetic Tool
Mice are a crucial resource for the scientific community. Scientific researchers from numerous disciplines use the mouse as a model to mimic and recapitulate diseases and test scientific questions related to human health and disease. These efforts include basic research, studies on the pathogenesis of disease, therapeutics to treat disease, markers for the diagnosis of disease, and strategies (e.g., vaccines) to prevent disease (Figure 1).