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ORIP Support for Small Businesses Leads to New Commercial Technology Outcomes That Benefit Community Resources and Advance Research Discoveries

ORIP participates in two federal grant programs that provide funding to small businesses: the Small Business Innovation Research (SBIR) program and the Small Business Technology Transfer (STTR) program. The primary goal of ORIP’s small business programs is to attract innovative SBIR/STTR projects that could benefit research resources and communities associated with ORIP’s mission.

Gnotobiotic Mouse Resources Support Studies of Microbial Interactions

Microorganisms affect nearly every aspect of life, regulating numerous biological processes at the ecosystem and organismal levels. All multi-organ animals maintain a unique gut microbiome that plays a key role in regulation of their metabolic, immune, and neurological functions. This area of research has expanded thanks to studies catalyzed by the NIH Human Microbiome Project, but the functional consequences of microbial changes—and the role of individual bacterial species and combinations—remain unknown.

Reproducibility of Rodent Models for Human Disease: MiniMUGA as a Critical Genetic Tool

Mice are a crucial resource for the scientific community. Scientific researchers from numerous disciplines use the mouse as a model to mimic and recapitulate diseases and test scientific questions related to human health and disease. These efforts include basic research, studies on the pathogenesis of disease, therapeutics to treat disease, markers for the diagnosis of disease, and strategies (e.g., vaccines) to prevent disease (Figure 1).

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