Division of Construction and Instruments

ORIP’s Division of Construction and Instruments (DCI) supports research infrastructure in three areas: the S10 Instrumentation Programs (acquisition of state-of-the-art research instruments), the S15 Equipment Program (acquisition of modern research or auxiliary equipment to enhance operations of shared-use biomedical research facilities, formerly under the R24 activity code), and Extramural Construction Programs (construction and modernization of research facilities).

For more information on the S10 and S15 programs, view DCI's fact sheets:

C06 Extramural Construction Programs

S10 Instrumentation Programs

S15 Equipment Program

DCI Funding Opportunities

DCI Awards

New S10 Publications

DCI News and Research Highlights

Dr. Eric A. Hoffman (right), Advanced Pulmonary Physiomic Imaging Laboratory (APPIL) Director, and Dr. Jessica C. Sieren (left), APPIL Deputy Director.

Seeing the Invisible: Detecting Early Lung Diseases with Advanced Computed Tomographic Imaging

For decades, physicians have relied on spirometry to detect chronic obstructive pulmonary disease (COPD). However, the global metrics derived from spirometry (a noninvasive breathing test) cannot sense regional lung damage in early disease.

NMR of bacterial extracellular vesicles reveals pH-driven conformational change of the Salmonella surface protein PagC.

Structural Studies In Situ Show How Bacteria Infect Humans, Leading to Chronic Diseases

Understanding the biological mechanisms that support human health and drive disease is essential for developing preventive and curative therapeutics. Direct structural analyses of proteins in their native environment are even more important.

Germ-free breeding cages in a gnotobiotic mouse facility.

NIH-Funded Gnotobiotic Facility Advances Microbiome Research in Chronic Liver Diseases and Obese Conditions at the University of California, San Diego

Many areas of biological research—including immunology, metabolic disorders, neurology, infectious disease, cancer, and translational microbiome research—require a well-controlled environment to study the role of the microbiome and host–microbe interactions.

S10 Mass Spectrometers Accelerate Collaborations on Aging and Women’s Health Research

Scientific and health innovations rely on continuous access to cutting-edge technology and instruments. Dr. Birgit Schilling, Professor, Buck Institute for Research on Aging, and Director of the Proteomics Core and Mass Spectrometry Center, knows this better than most.

Architecture and antigenicity of the PRD-0038 S trimer

New S10 Publications

This list of recent publications is sourced from PubMed and has been curated. For an exhaustive list please visit PubMed.

Author List	Title	Journal Title	Publication Date
Saiswaroop Rajaratnam,Danthasinghe Waduge Badrajee Piyarathna,Ranjit K Mehta,Venugopalareddy Mekala…	DHODH links mitochondrial bioenergetics, one-carbon metabolism, and DNA repair to sustain aggressive prostate adenocarcinoma	Cell communication and signaling : CCS	2026-01-30
Maria A Vratsanos,Evangelos Bakalis,Chiwoo Park,Francesco Zerbetto,Nathan C Gianneschi	Liquid Phase TEM of Diffusing Emulsion Droplets	Small (Weinheim an der Bergstrasse, Germany)	2026-01-30
Chao Tang,Jiaxin Yang,Xiaoyang Lei,Ming Zhang,Yi Chen,Xiaoxue Peng,Dian He	Association between brain volume and depression in Alzheimer's disease: Neuroimaging insights	Alzheimer's & dementia : the journal of the Alzheimer's Association	2026-01-29
Chenyang Zhao,Fanhua Guo,Zidong Yang,Xingfeng Shao,Samantha J Ma,Alexander J S Beckett,An T Vu…	Next Generation 7 Tesla Arterial Spin Labeling With Rotated Spiral Acquisition Enables Mesoscale Resolution in 3D Brain Perfusion and Functional MRI	Magnetic resonance in medicine	2026-01-29
Brianna M Krusen,Phyllis A Gimotty,Greg Donahue,Jacob E Till,Melinda Yin,Erin E Carlson,William R…	Improving a Plasma Biomarker Panel for Early Detection of Pancreatic Ductal Adenocarcinoma with Aminopeptidase N (ANPEP) and Polymeric Immunoglobin Receptor (PIGR)	Clinical cancer research : an official journal of the American Association for Cancer Research	2026-01-28