Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences; Shenzhen Third People's Hospital; Guangzhou Medical University; UT Southwestern Medical Center; and others
Keywords: SARS-CoV-2, fusion protein vaccine, immune response, rodents and primates
Summary of Study: the pan-epitope modified human I-R-F (I-P-R-F) vaccine provides rapid and complete protection throughout the upper and lower respiratory tracts against a high-dose SARS-C0V-2 challenge in rhesus macaques.
References: PMID: 34267349 / doi: 10.1038/s41422-021-00531-8
Contact Info: Yang-Xin Fu: [email protected]
URL: https://www.nature.com/articles/s41422-021-00531-8
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences; Shenzhen Third People's Hospital; Guangzhou Medical University; UT Southwestern Medical Center; and others
Keywords: SARS-CoV-2, fusion protein vaccine, immune response, rodents and primates
Summary of Study: the pan-epitope modified human I-R-F (I-P-R-F) vaccine provides rapid and complete protection throughout the upper and lower respiratory tracts against a high-dose SARS-C0V-2 challenge in rhesus macaques.
References: PMID: 34267349 / doi: 10.1038/s41422-021-00531-8
Contact Info: Yang-Xin Fu: [email protected]
URL: https://www.nature.com/articles/s41422-021-00531-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Milad Daro Noor Pharmaceutical (MDNP) Co., Iran; Stem Cell Technology Research Center (STRC); Imam Hussein University
Keywords: SARS-CoV-2, inactivated vaccine candidate, immunization, immune response, mice, guinea pigs, rabbits, primates
Summary of Study: FAKHRAVAC, a purified inactivated SARS-CoV-2 virus vaccine candidate induced neutralizing antibodies in Balb/c mice, guinea pigs, rabbits, and rhesus macaques.
References: PMID: 34835202 / doi: 10.3390/vaccines9111271
Contact Info: Ahmad Karimi Rahjerdi: [email protected] or [email protected]
URL: https://www.mdpi.com/2076-393X/9/11/1271
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Milad Daro Noor Pharmaceutical (MDNP) Co., Iran; Stem Cell Technology Research Center (STRC); Imam Hussein University
Keywords: SARS-CoV-2, inactivated vaccine candidate, immunization, immune response, mice, guinea pigs, rabbits, primates
Summary of Study: FAKHRAVAC, a purified inactivated SARS-CoV-2 virus vaccine candidate induced neutralizing antibodies in Balb/c mice, guinea pigs, rabbits, and rhesus macaques.
References: PMID: 34835202 / doi: 10.3390/vaccines9111271
Contact Info: Ahmad Karimi Rahjerdi: [email protected] or [email protected]
URL: https://www.mdpi.com/2076-393X/9/11/1271
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Eli Lilly and Co., AbCellera Biologics, UNC - Chapel Hill, University of Texas Medical Branch, and others.
Keywords: SARS-CoV-2, monoclonal antibodies, immune response, primates
Summary of Study: LY-CoV555 (aka bamlanivimab), a potent anti-spike neutralizing antibody from a hospitalized, convalescent patient with COVID-19 was followed in a pharmacokinetic study in cynomolgus monkeys and in a challenge model in rhesus macaques, where it showed impressive results. Currently in clinical testing.
References: PMID: 33820835 / doi: 10.1126/scitranslmed.abf1906
Contact Info: Bryan Jones: [email protected]; Ester Falconer: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abf1906?url_ver=Z39.88-2003&rf…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Eli Lilly and Co., AbCellera Biologics, UNC - Chapel Hill, University of Texas Medical Branch, and others.
Keywords: SARS-CoV-2, monoclonal antibodies, immune response, primates
Summary of Study: LY-CoV555 (aka bamlanivimab), a potent anti-spike neutralizing antibody from a hospitalized, convalescent patient with COVID-19 was followed in a pharmacokinetic study in cynomolgus monkeys and in a challenge model in rhesus macaques, where it showed impressive results. Currently in clinical testing.
References: PMID: 33820835 / doi: 10.1126/scitranslmed.abf1906
Contact Info: Bryan Jones: [email protected]; Ester Falconer: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abf1906?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Washington Univ, SW National Primate Research Center, Texas Biomedical Research Institute
Keywords: SARS-CoV-2, transcriptional signatures, juvenile and old animals, lungs, primates
Summary of Study: Transcriptional profiles of lungs from juvenile and old macaques infected with SARS-CoV-2 were interrogated, providing fundamentally new information on the host response in young and old macaques. This model provides relevant insights necessary for further vaccine and therapeutic development for COVID-19.
References: PMID: 33674719 / doi: 10.1038/s42003-021-01829-4
Contact Info: Makedonka Mitreva: [email protected]; Deepak Kaushal: [email protected]
URL: https://www.nature.com/articles/s42003-021-01829-4
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Washington Univ, SW National Primate Research Center, Texas Biomedical Research Institute
Keywords: SARS-CoV-2, transcriptional signatures, juvenile and old animals, lungs, primates
Summary of Study: Transcriptional profiles of lungs from juvenile and old macaques infected with SARS-CoV-2 were interrogated, providing fundamentally new information on the host response in young and old macaques. This model provides relevant insights necessary for further vaccine and therapeutic development for COVID-19.
References: PMID: 33674719 / doi: 10.1038/s42003-021-01829-4
Contact Info: Makedonka Mitreva: [email protected]; Deepak Kaushal: [email protected]
URL: https://www.nature.com/articles/s42003-021-01829-4
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Hebei Agricultural University; Military Veterinary Research Institute
Keywords: SARS-CoV-2, aerosol particles, virus transduction, primates
Summary of Study: Most SARS-CoV-2 aerosol particles exhaled by the cynomolgus monkeys in this study were smaller (<4.7 um), suggesting that aerosols might be a route for SARS-CoV-2 transmission.
References: PMID: 34152969 / doi: 10.3201/eid2707.203948
Contact Info: Yuwei Gao: [email protected]
URL: https://wwwnc.cdc.gov/eid/article/27/7/20-3948_article
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Hebei Agricultural University; Military Veterinary Research Institute
Keywords: SARS-CoV-2, aerosol particles, virus transduction, primates
Summary of Study: Most SARS-CoV-2 aerosol particles exhaled by the cynomolgus monkeys in this study were smaller (<4.7 um), suggesting that aerosols might be a route for SARS-CoV-2 transmission.
References: PMID: 34152969 / doi: 10.3201/eid2707.203948
Contact Info: Yuwei Gao: [email protected]
URL: https://wwwnc.cdc.gov/eid/article/27/7/20-3948_article
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Nankai University, Chinese Academy of Sciences, and others
Keywords: SARS-CoV-2, monoclonal antibodies, structure analysis, immune response, primates
Summary of Study: The engineered antibody P4A1 (originally identified from COVID-19 convalescent patients) exhibits an optimized pharmacokinetic and safety profile, and results in complete viral clearance in a rhesus monkey model of COVID-19 following a single injection.
References: PMID: 33976198 / doi: 10.1038/s41467-021-22926-2
Contact Info: Yu Guo: [email protected]; Hongkai Zhang: [email protected]
URL: https://www.nature.com/articles/s41467-021-22926-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Nankai University, Chinese Academy of Sciences, and others
Keywords: SARS-CoV-2, monoclonal antibodies, structure analysis, immune response, primates
Summary of Study: The engineered antibody P4A1 (originally identified from COVID-19 convalescent patients) exhibits an optimized pharmacokinetic and safety profile, and results in complete viral clearance in a rhesus monkey model of COVID-19 following a single injection.
References: PMID: 33976198 / doi: 10.1038/s41467-021-22926-2
Contact Info: Yu Guo: [email protected]; Hongkai Zhang: [email protected]
URL: https://www.nature.com/articles/s41467-021-22926-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, neurotropism, central neural system, virus transduction, primates
Summary of Study: The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys.
References: PMID: 33895780 / doi: 10.1038/s41392-021-00591-7
Contact Info: Xiaozhong Peng: [email protected]; Shuaiyao Lu: [email protected]; Hongqi Liu: [email protected]
URL: https://www.nature.com/articles/s41392-021-00591-7
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, neurotropism, central neural system, virus transduction, primates
Summary of Study: The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys.
References: PMID: 33895780 / doi: 10.1038/s41392-021-00591-7
Contact Info: Xiaozhong Peng: [email protected]; Shuaiyao Lu: [email protected]; Hongqi Liu: [email protected]
URL: https://www.nature.com/articles/s41392-021-00591-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, resources, pathology, primates
Summary of Study: Because the SARS-CoV-2 pandemic has significantly increased the demand for rhesus macaques biomedical researchers will need to consider alternative NHP models for COVID-19 research and for other biomedical research studies. The authors suggest alternatives.
References: PMID: 33785923 / doi: 10.1038/s41684-021-00755-6
Contact Info: Michael Chang: chang,[email protected]
URL: https://www.nature.com/articles/s41684-021-00755-6
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, resources, pathology, primates
Summary of Study: Because the SARS-CoV-2 pandemic has significantly increased the demand for rhesus macaques biomedical researchers will need to consider alternative NHP models for COVID-19 research and for other biomedical research studies. The authors suggest alternatives.
References: PMID: 33785923 / doi: 10.1038/s41684-021-00755-6
Contact Info: Michael Chang: chang,[email protected]
URL: https://www.nature.com/articles/s41684-021-00755-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, pigtail macaques, african green monkeys, squirrel monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIAID
Keywords: SARS-CoV-2, pulmonary histopathologic characteristics, immunohistochemistry, species comparison, primates
Summary of Study: Histopathology does not appear to be a superior readout for interpretation of vaccine and therapeutic evaluations in the NHPs studied. The recommendation of which NHP is a superior model should be based on virology data as well as further work on genetic factors that contribute to significant disease.
References: PMID: 34963391 / doi: 10.1177/03009858211067468
Contact Info: Chad Clancy: [email protected]
URL: https://journals.sagepub.com/doi/10.1177/03009858211067468?url_ver=Z39.88-2003&…
NHP Species: rhesus macaques, pigtail macaques, african green monkeys, squirrel monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIAID
Keywords: SARS-CoV-2, pulmonary histopathologic characteristics, immunohistochemistry, species comparison, primates
Summary of Study: Histopathology does not appear to be a superior readout for interpretation of vaccine and therapeutic evaluations in the NHPs studied. The recommendation of which NHP is a superior model should be based on virology data as well as further work on genetic factors that contribute to significant disease.
References: PMID: 34963391 / doi: 10.1177/03009858211067468
Contact Info: Chad Clancy: [email protected]
URL: https://journals.sagepub.com/doi/10.1177/03009858211067468?url_ver=Z39.88-2003&…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Universite Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases; University of Amsterdam; Universite de Paris, INSERM, IAME; University of Texas Medical Branch at Galveston; Galveston National Laboratory; Icahn School of Medicine at Mount Sinai; The Scripps Research Institute; Duke Human Vaccine Institute & Department of Surgery; Nexelis; The University of Maryland School of Medicine; Institut Pasteur; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, neutralizing antibody, prophylactic, pathology, mice, hamsters, primates
Summary of Study: COVA1-18, a neutralizing antibody highly potent against the B.1.1.7 isolate, has a strong antiviral activity in three preclinical models and could be a valuable candidate for further clinical evaluation.
References: PMID: 34671037 / doi: 10.1038/s41467-021-26354-0
Contact Info: Rogier Sanders: [email protected]; Marit van Gils: [email protected]; Roger Le Grand: [email protected]
URL: https://www.nature.com/articles/s41467-021-26354-0
NHP Species:
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Universite Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases; University of Amsterdam; Universite de Paris, INSERM, IAME; University of Texas Medical Branch at Galveston; Galveston National Laboratory; Icahn School of Medicine at Mount Sinai; The Scripps Research Institute; Duke Human Vaccine Institute & Department of Surgery; Nexelis; The University of Maryland School of Medicine; Institut Pasteur; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, neutralizing antibody, prophylactic, pathology, mice, hamsters, primates
Summary of Study: COVA1-18, a neutralizing antibody highly potent against the B.1.1.7 isolate, has a strong antiviral activity in three preclinical models and could be a valuable candidate for further clinical evaluation.
References: PMID: 34671037 / doi: 10.1038/s41467-021-26354-0
Contact Info: Rogier Sanders: [email protected]; Marit van Gils: [email protected]; Roger Le Grand: [email protected]
URL: https://www.nature.com/articles/s41467-021-26354-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Pasteur Institute of Iran; Amirabad Virology Laboratory; Tarbiat Modares University; University of Tehran; Islamic Azad University; Hamadan University of Medical Sciences; Darou Pakhsh Pharmaceutical; Arena Diagnostic; and others.
Keywords: SARS-CoV-2, inactivated whole-virus vaccine, safety, immune response, guinea pig, rabbit, mice, primates
Summary of Study: Rhesus macaques were immunised with the two-dose schedule of 5 or 3 ug of the B1V1-CovIran vaccine and showed highly efficient protection against 10^4 TCID50 of SARS-CoV-2 intratracheal challenge compared with the control group.
References: PMID: 34699647 / doi: 10.1002/rmv.2305
Contact Info: Reza Aalizadeh: [email protected]; Hasan Jalili: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/rmv.2305
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Pasteur Institute of Iran; Amirabad Virology Laboratory; Tarbiat Modares University; University of Tehran; Islamic Azad University; Hamadan University of Medical Sciences; Darou Pakhsh Pharmaceutical; Arena Diagnostic; and others.
Keywords: SARS-CoV-2, inactivated whole-virus vaccine, safety, immune response, guinea pig, rabbit, mice, primates
Summary of Study: Rhesus macaques were immunised with the two-dose schedule of 5 or 3 ug of the B1V1-CovIran vaccine and showed highly efficient protection against 10^4 TCID50 of SARS-CoV-2 intratracheal challenge compared with the control group.
References: PMID: 34699647 / doi: 10.1002/rmv.2305
Contact Info: Reza Aalizadeh: [email protected]; Hasan Jalili: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/rmv.2305
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Universite paris-Saclay/Inserm/Cea; Pereman School of Medicine; Novartis Gene Therapies; Boston University School of Medicine; Ragon Institute of MGH, MIT, and Harvard; and others
Keywords: SARS-CoV-2, AAV-vaccine candidates, immune response, mice, primates
Summary of Study: Studies of the AAV-based vaccine candidate AC1 support its potential to protect from COVID-19 disease and infection from a single-dose immunization; may lead to highly durable immunogenicity; and is stable at ambient temperature for storage for several weeks. The combination of these WHO-specific key attributes have not been met by any of the currently approved vaccines. Continued development of second-generation vaccine candidates such at AC1 is needed.
References: PMID: 34428428 / doi: 10.1016/j.chom.2021.08.002
Contact Info: Roger LeGrand: [email protected]; Luk Vandenberghe: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1931312821003784?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Universite paris-Saclay/Inserm/Cea; Pereman School of Medicine; Novartis Gene Therapies; Boston University School of Medicine; Ragon Institute of MGH, MIT, and Harvard; and others
Keywords: SARS-CoV-2, AAV-vaccine candidates, immune response, mice, primates
Summary of Study: Studies of the AAV-based vaccine candidate AC1 support its potential to protect from COVID-19 disease and infection from a single-dose immunization; may lead to highly durable immunogenicity; and is stable at ambient temperature for storage for several weeks. The combination of these WHO-specific key attributes have not been met by any of the currently approved vaccines. Continued development of second-generation vaccine candidates such at AC1 is needed.
References: PMID: 34428428 / doi: 10.1016/j.chom.2021.08.002
Contact Info: Roger LeGrand: [email protected]; Luk Vandenberghe: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1931312821003784?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID, Ragon Institute of MGH, MIT< and Harvard, University of Duisburg-Essen, Harvard University, Emory Vaccine Center, Yerkes National Primate Research Center, and others
Keywords: SARS-CoV-2, protein subunit vaccine, soluble prefusion-stabilized spike trimers, immune response, primates
Summary of Study: Soluble prefusion-stablized spike protein trimers (preS DTM) from SARS-CoV-2 were formulated with the adjuvant AS03 and administered twice to NHPs. Two days after challenge, vaccinated NHPs showed rapid control of viral replication in both the upper and lower airways. These data indicate that antibodies induced by the AS03-adjuvanted preS dTM vaccine were sufficient to mediate protection against SARS-CoV-2 in NHPs and that rapid anamnestic antibody responses in the lung may be a key mechanism for protection.
References: PMID: 34315825 / doi: 10.1126/scitranslmed.abi4547
Contact Info: Robert Seder: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abi4547?url_ver=Z39.88-2003&rf…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID, Ragon Institute of MGH, MIT< and Harvard, University of Duisburg-Essen, Harvard University, Emory Vaccine Center, Yerkes National Primate Research Center, and others
Keywords: SARS-CoV-2, protein subunit vaccine, soluble prefusion-stabilized spike trimers, immune response, primates
Summary of Study: Soluble prefusion-stablized spike protein trimers (preS DTM) from SARS-CoV-2 were formulated with the adjuvant AS03 and administered twice to NHPs. Two days after challenge, vaccinated NHPs showed rapid control of viral replication in both the upper and lower airways. These data indicate that antibodies induced by the AS03-adjuvanted preS dTM vaccine were sufficient to mediate protection against SARS-CoV-2 in NHPs and that rapid anamnestic antibody responses in the lung may be a key mechanism for protection.
References: PMID: 34315825 / doi: 10.1126/scitranslmed.abi4547
Contact Info: Robert Seder: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abi4547?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: The Catholic University of Korea, Korea Research Institute of Bioscience and Biotechnology, SK Science, Jeonbuk National University, and others
Keywords: SARS-CoV-2, receptor-binding domain of SARS-CoV-2, immune response, mice and primates
Summary of Study: RBD-P2 + alum immunization elicits a robust neutralizing antibody response and provides complete or near-complete elimination of live SARS-CoV-2 virus particles. Additionally, findings provide insight into the potential use of the N protein in the development of SARS-CoV-2 vaccines.
References: PMID: 34049881 / doi: 10.1126/sciadv.abg7156
Contact Info: Jae-Hwan Nam: [email protected]; Sang-Myeong Lee: [email protected]; Jung Joo Hong: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.abg7156?url_ver=Z39.88-2003&rfr_id=o…
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: The Catholic University of Korea, Korea Research Institute of Bioscience and Biotechnology, SK Science, Jeonbuk National University, and others
Keywords: SARS-CoV-2, receptor-binding domain of SARS-CoV-2, immune response, mice and primates
Summary of Study: RBD-P2 + alum immunization elicits a robust neutralizing antibody response and provides complete or near-complete elimination of live SARS-CoV-2 virus particles. Additionally, findings provide insight into the potential use of the N protein in the development of SARS-CoV-2 vaccines.
References: PMID: 34049881 / doi: 10.1126/sciadv.abg7156
Contact Info: Jae-Hwan Nam: [email protected]; Sang-Myeong Lee: [email protected]; Jung Joo Hong: [email protected]
URL: https://www.science.org/doi/10.1126/sciadv.abg7156?url_ver=Z39.88-2003&rfr_id=o…
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine; Tulane National Primate Research Center; SE LA Veterans Affairs Healthcare System, and others
Keywords: SARS-CoV-2, severe acute respiratory syndrome and diabetes, chronic pancreatic dysfunction, primates
Summary of Study: SARS-CoV-2 infects pancreatic islet, ductal, and endothelial cells in male and female NHPs and humans with COVID-19. The long-term consequences of a fibrotic/thrombotic pancreas, such as chronic pancreatic exocrine dysfunction and late-onset diabetes, should be investigated as postacute sequelae of COVID-19.
References: PMID: 34241597 / doi: 10.1172/jci.insight.151551
Contact Info: Mirza Muhammad Fahd Qadir: [email protected]; Rudolf Bohm: [email protected]
URL: https://insight.jci.org/articles/view/151551
NHP Species: african green monkeys, rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane University School of Medicine; Tulane National Primate Research Center; SE LA Veterans Affairs Healthcare System, and others
Keywords: SARS-CoV-2, severe acute respiratory syndrome and diabetes, chronic pancreatic dysfunction, primates
Summary of Study: SARS-CoV-2 infects pancreatic islet, ductal, and endothelial cells in male and female NHPs and humans with COVID-19. The long-term consequences of a fibrotic/thrombotic pancreas, such as chronic pancreatic exocrine dysfunction and late-onset diabetes, should be investigated as postacute sequelae of COVID-19.
References: PMID: 34241597 / doi: 10.1172/jci.insight.151551
Contact Info: Mirza Muhammad Fahd Qadir: [email protected]; Rudolf Bohm: [email protected]
URL: https://insight.jci.org/articles/view/151551
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: YishengBio Co., Ltd.; Chinese Academy of Sciences; National Health Commission of the People's Republic of China
Keywords: SARS-CoV-2, S-trimer, PIKA, vaccine, virus genomic variants, primates
Summary of Study: In this study of non-human primates, PIKA adjuvanted S-trimer induced high SARS-CoV-2 neutralization titers and protected from virus replication in the lung following SARS-CoV-2 challenge.
References: PMID: 34766005 / doi: 10.1186/s43556-021-00054-z
Contact Info: Yi Zhang: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475395/
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: YishengBio Co., Ltd.; Chinese Academy of Sciences; National Health Commission of the People's Republic of China
Keywords: SARS-CoV-2, S-trimer, PIKA, vaccine, virus genomic variants, primates
Summary of Study: In this study of non-human primates, PIKA adjuvanted S-trimer induced high SARS-CoV-2 neutralization titers and protected from virus replication in the lung following SARS-CoV-2 challenge.
References: PMID: 34766005 / doi: 10.1186/s43556-021-00054-z
Contact Info: Yi Zhang: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475395/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Nagoya University; Kyushu University; Akita University Graduate School of Medicine; and others
Keywords: SARS-CoV-2, mathematical model, infection dynamics, kinetics of viral shedding, primates
Summary of Study: The authors used a simple mathematical model to quantify SARS-CoV-2 infection dynamics in rhesus macaques. When antiviral treatments are initiated early (i.e. 0.5 d after virus inoculation), viral shedding is (paradoxically) prolonged by about 6.0 days compared with no treatment.
References: PMID: 34344719 / doi: 10.26508/lsa.202101049
Contact Info: Keisuke Ejima: [email protected]; Shingo Iwami: [email protected]
URL: https://www.life-science-alliance.org/content/4/10/e202101049
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Nagoya University; Kyushu University; Akita University Graduate School of Medicine; and others
Keywords: SARS-CoV-2, mathematical model, infection dynamics, kinetics of viral shedding, primates
Summary of Study: The authors used a simple mathematical model to quantify SARS-CoV-2 infection dynamics in rhesus macaques. When antiviral treatments are initiated early (i.e. 0.5 d after virus inoculation), viral shedding is (paradoxically) prolonged by about 6.0 days compared with no treatment.
References: PMID: 34344719 / doi: 10.26508/lsa.202101049
Contact Info: Keisuke Ejima: [email protected]; Shingo Iwami: [email protected]
URL: https://www.life-science-alliance.org/content/4/10/e202101049
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Sanofi Pasteur, Yoh Services, Global Discovery Pathology, Translate Bio
Keywords: SARS-CoV-2, multiple animal species, mRNA vaccine, immune response, pathology, primates
Summary of Study: Several mRNA vaccine candidates were assessed; the lead 2P/GSAS vaccine formulation (designated MRT550) elicited potent nAbs as well as TH1-biased responses in NHPs, thus alleviating a hypothetical concern of potential vaccine-associated enhanced respiratory diseases known associated with TH2-biased responses. These data position MRT5500 as a viable vaccine candidate for entering clinical development.
References: PMID: 33875658 / doi: 10.1038/s41541-021-00324-5
Contact Info: Kirill Kalnin: [email protected]
URL: https://www.nature.com/articles/s41541-021-00324-5
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Sanofi Pasteur, Yoh Services, Global Discovery Pathology, Translate Bio
Keywords: SARS-CoV-2, multiple animal species, mRNA vaccine, immune response, pathology, primates
Summary of Study: Several mRNA vaccine candidates were assessed; the lead 2P/GSAS vaccine formulation (designated MRT550) elicited potent nAbs as well as TH1-biased responses in NHPs, thus alleviating a hypothetical concern of potential vaccine-associated enhanced respiratory diseases known associated with TH2-biased responses. These data position MRT5500 as a viable vaccine candidate for entering clinical development.
References: PMID: 33875658 / doi: 10.1038/s41541-021-00324-5
Contact Info: Kirill Kalnin: [email protected]
URL: https://www.nature.com/articles/s41541-021-00324-5
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Science, Trinomab Biotech Co.
Keywords: SARS-CoV-2, ferritin nanoparticles, receptor-binding domain of SARS-CoV-2, immune response, primates
Summary of Study: Self-assembling nanoparticle vaccines displaying the RBD of SARS-CoV-2 were prepared, and the vaccine candidate elicited robust humoral and T cell responses and protected the rhesus monkeys from infection with short-term shedding and only minor pathological damage.
References: PMID: 33951913 / doi: 10.1021/acs.bioconjchem.1c00208
Contact Info: Longding Liu: [email protected]; Qihan Li: [email protected]; Zhanlong He: [email protected]
URL: https://pubs.acs.org/doi/10.1021/acs.bioconjchem.1c00208
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Science, Trinomab Biotech Co.
Keywords: SARS-CoV-2, ferritin nanoparticles, receptor-binding domain of SARS-CoV-2, immune response, primates
Summary of Study: Self-assembling nanoparticle vaccines displaying the RBD of SARS-CoV-2 were prepared, and the vaccine candidate elicited robust humoral and T cell responses and protected the rhesus monkeys from infection with short-term shedding and only minor pathological damage.
References: PMID: 33951913 / doi: 10.1021/acs.bioconjchem.1c00208
Contact Info: Longding Liu: [email protected]; Qihan Li: [email protected]; Zhanlong He: [email protected]
URL: https://pubs.acs.org/doi/10.1021/acs.bioconjchem.1c00208
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Dalhousie University; University of Calgary
Keywords: SARS-CoV-2, anthropozoonosis, virus transmission between the animal species, primates
Summary of Study: While the risk of transmission of SARS-CoV-2 via wastewater is low, tracing of viral RNA in wastewater does provide a unique testing approach to help protect NHPs at zoos and wildlife sanctuaries.
References: PMID: 34662463 / doi: 10.1002/ajp.23340
Contact Info: Graham Dellaire: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/ajp.23340
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Dalhousie University; University of Calgary
Keywords: SARS-CoV-2, anthropozoonosis, virus transmission between the animal species, primates
Summary of Study: While the risk of transmission of SARS-CoV-2 via wastewater is low, tracing of viral RNA in wastewater does provide a unique testing approach to help protect NHPs at zoos and wildlife sanctuaries.
References: PMID: 34662463 / doi: 10.1002/ajp.23340
Contact Info: Graham Dellaire: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/ajp.23340
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Perelman School of Medicine (UPenn)
Keywords: SARS-CoV-2, clinical and pathologic consequences, ACE2 decoy protein, primates
Summary of Study: The ACE2 decoy (soluble forms of angiotensin-converting enzyme 2) gene therapy approach could be effectively deployed to vulnerable populations in the COVID-19 pandemic and potentially to broader populations at the outset of future coronavirus pandemics.
References: PMID: 34265018 / doi: 10.1371/journal.ppat.1009544
Contact Info: James Wilson: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009544
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Perelman School of Medicine (UPenn)
Keywords: SARS-CoV-2, clinical and pathologic consequences, ACE2 decoy protein, primates
Summary of Study: The ACE2 decoy (soluble forms of angiotensin-converting enzyme 2) gene therapy approach could be effectively deployed to vulnerable populations in the COVID-19 pandemic and potentially to broader populations at the outset of future coronavirus pandemics.
References: PMID: 34265018 / doi: 10.1371/journal.ppat.1009544
Contact Info: James Wilson: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009544
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Washington Univ SOM, NIAID
Keywords: SARS-CoV-2, adenovirus-vectored vaccine, immunogenicity and protective efficacy, primates
Summary of Study: A single intranasal dose of ChAd-SARS-CoV-2-S induces neutralizing antibodies and T cell responses and limits or prevents infection in the upper and lower respiratory tracts after SARS-CoV-2 challenge in rhesus macaques.
References: PMID: 33754147 / doi: 10.1016/j.xcrm.2021.100230
Contact Info: Heinz Feldmann: [email protected]; Michael Diamond: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S266637912100046X?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Washington Univ SOM, NIAID
Keywords: SARS-CoV-2, adenovirus-vectored vaccine, immunogenicity and protective efficacy, primates
Summary of Study: A single intranasal dose of ChAd-SARS-CoV-2-S induces neutralizing antibodies and T cell responses and limits or prevents infection in the upper and lower respiratory tracts after SARS-CoV-2 challenge in rhesus macaques.
References: PMID: 33754147 / doi: 10.1016/j.xcrm.2021.100230
Contact Info: Heinz Feldmann: [email protected]; Michael Diamond: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S266637912100046X?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; CureVac AG
Keywords: SARS-CoV-2, mRNA-vaccine, spike protein, humoral and cellular immune responses, primates
Summary of Study: Prime-boost vaccination with 4 ug of vaccine candidate CV07050101 resulted in limited immune responses in four out of six non-human primates.
References: PMID: 34452509 / doi: 10.3390/v13081645
Contact Info: Vincent Munster: [email protected]
URL: https://www.mdpi.com/1999-4915/13/8/1645
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; CureVac AG
Keywords: SARS-CoV-2, mRNA-vaccine, spike protein, humoral and cellular immune responses, primates
Summary of Study: Prime-boost vaccination with 4 ug of vaccine candidate CV07050101 resulted in limited immune responses in four out of six non-human primates.
References: PMID: 34452509 / doi: 10.3390/v13081645
Contact Info: Vincent Munster: [email protected]
URL: https://www.mdpi.com/1999-4915/13/8/1645
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIH
Keywords: SARS-CoV-2, single-cell RNA sequencing, lung cells, primates
Summary of Study: Monocyte-derived macrophages recruited to the lungs, rather than tissue-resident alveolar macrophages, were most likely to be responsible for phagocytosis of infected cells and cellular debris early in infection, with their roles switching during clearance of infection.
References: PMID: 33431511 / doi: 10.1126/scitranslmed.abe8146
Contact Info: Emmie DeWit: [email protected]
URL: https://stm.sciencemag.org/content/13/578/eabe8146.short
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIH
Keywords: SARS-CoV-2, single-cell RNA sequencing, lung cells, primates
Summary of Study: Monocyte-derived macrophages recruited to the lungs, rather than tissue-resident alveolar macrophages, were most likely to be responsible for phagocytosis of infected cells and cellular debris early in infection, with their roles switching during clearance of infection.
References: PMID: 33431511 / doi: 10.1126/scitranslmed.abe8146
Contact Info: Emmie DeWit: [email protected]
URL: https://stm.sciencemag.org/content/13/578/eabe8146.short
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: NCR Biotech Science Cluster; Indian Institute of Technology Kharagpur; Krishi Vigyan Kendra; Inter University Centre for Biomedical Research and Super Speciality Hospital
Keywords: SARS-CoV-2, zoonotic diseases, one health approach, multiple species, primates
Summary of Study: This review examines the different natural and experimentally induced cases of human to animal SARS-CoV-2 infection (reverse zoonosis).
References: PMID: 34903944 / doi: 10.14202/vetworld.2021.2817-2826
Contact Info: R. Kumar Pramod: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654767/pdf/Vetworld-14-2817.pdf
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: NCR Biotech Science Cluster; Indian Institute of Technology Kharagpur; Krishi Vigyan Kendra; Inter University Centre for Biomedical Research and Super Speciality Hospital
Keywords: SARS-CoV-2, zoonotic diseases, one health approach, multiple species, primates
Summary of Study: This review examines the different natural and experimentally induced cases of human to animal SARS-CoV-2 infection (reverse zoonosis).
References: PMID: 34903944 / doi: 10.14202/vetworld.2021.2817-2826
Contact Info: R. Kumar Pramod: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654767/pdf/Vetworld-14-2817.pdf
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Shanghai Zerun Biotechnology Co., Ltd.; Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College; Shanghai Medical College, Fudan University; Wuhan University; National Institute for Food and Drug Control (NIFDC)
Keywords: SARS-CoV-2, recombinant vaccine, spike trimer, immunogenicity, mice, hamsters, primates
Summary of Study: A recombinant spike protein vaccine adjuvanted with aluminium hydroxide and CpG 7909 showed high immunogenicity and good protective efficacy in preclinical studies, supporting further clinical trials.
References: PMID: 34750014 / doi: 10.1016/j.vaccine.2021.10.066
Contact Info: Ge Liu: [email protected]; Jiangning Liu: [email protected]; Youhua Xie: [email protected]; Zhongyu Hu: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21013992?via%3Dihub=
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Shanghai Zerun Biotechnology Co., Ltd.; Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College; Shanghai Medical College, Fudan University; Wuhan University; National Institute for Food and Drug Control (NIFDC)
Keywords: SARS-CoV-2, recombinant vaccine, spike trimer, immunogenicity, mice, hamsters, primates
Summary of Study: A recombinant spike protein vaccine adjuvanted with aluminium hydroxide and CpG 7909 showed high immunogenicity and good protective efficacy in preclinical studies, supporting further clinical trials.
References: PMID: 34750014 / doi: 10.1016/j.vaccine.2021.10.066
Contact Info: Ge Liu: [email protected]; Jiangning Liu: [email protected]; Youhua Xie: [email protected]; Zhongyu Hu: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21013992?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Henry M. Jackson Foundation for the Advancement of Military Medicine; Washington University; National Cancer Institute/NIH; BIOQUAL; and others
Keywords: SARS-CoV-2, nanoparticle protein vaccine, humoral and cellular immune responses, primates
Summary of Study: Findings support the continued development of SARS-CoV-2 RBD ferritin nanoparticle vaccines (RFN) for managing COVID-19 and related SARS-CoV-like virus outbreaks.
References: PMID: 34470866 / doi: 10.1073/pnas.2106433118
Contact Info: Kayvon Modjarrad: [email protected]; Diane Bolton: [email protected]
URL: https://www.pnas.org/content/118/38/e2106433118.long
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Henry M. Jackson Foundation for the Advancement of Military Medicine; Washington University; National Cancer Institute/NIH; BIOQUAL; and others
Keywords: SARS-CoV-2, nanoparticle protein vaccine, humoral and cellular immune responses, primates
Summary of Study: Findings support the continued development of SARS-CoV-2 RBD ferritin nanoparticle vaccines (RFN) for managing COVID-19 and related SARS-CoV-like virus outbreaks.
References: PMID: 34470866 / doi: 10.1073/pnas.2106433118
Contact Info: Kayvon Modjarrad: [email protected]; Diane Bolton: [email protected]
URL: https://www.pnas.org/content/118/38/e2106433118.long
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences, Kunming Institute of Zoology; Institute of Infectious Diseases, Shenzhen Bay Laboratory; School of Medicine, Tsinghua University
Keywords: SARS-CoV-2, receptor-binding domain subunit vaccine, humoral and cellular immune responses, pathology, primates
Summary of Study: A trimeric SARS-CoV-2 receptor-binding domain (RBD) subunit vaccine that stimulates the natural structure of the spike (S) trimer glycoprotein is highly immunogenic and safe, providing long-lasting, broad, and significant immunity protection in NHPs. The vaccine-induced antibodies can effectively neutralize the SARS-CoV-2 501Y.V2 variant. A booster vaccination can quickly activate the memory immune response to avoid re-infection.
References: PMID: 34179862 / doi: 10.1016/j.xinn.2021.100140
Contact Info: Limin Yang: [email protected]; Yong-tang Zheng: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214323/
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences, Kunming Institute of Zoology; Institute of Infectious Diseases, Shenzhen Bay Laboratory; School of Medicine, Tsinghua University
Keywords: SARS-CoV-2, receptor-binding domain subunit vaccine, humoral and cellular immune responses, pathology, primates
Summary of Study: A trimeric SARS-CoV-2 receptor-binding domain (RBD) subunit vaccine that stimulates the natural structure of the spike (S) trimer glycoprotein is highly immunogenic and safe, providing long-lasting, broad, and significant immunity protection in NHPs. The vaccine-induced antibodies can effectively neutralize the SARS-CoV-2 501Y.V2 variant. A booster vaccination can quickly activate the memory immune response to avoid re-infection.
References: PMID: 34179862 / doi: 10.1016/j.xinn.2021.100140
Contact Info: Limin Yang: [email protected]; Yong-tang Zheng: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214323/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre (BPRC); Eurofins-INGENASA; Erasmus University Medical Center; Utrecht University
Keywords: SARS-CoV-2, post-acute phase, immune response, tomography, virus replication, primates
Summary of Study: NHPs infected with SARS-CoV-2 were followed for up to 6 weeks and monitored for COVID-19-like disease symptoms. Data indicate widespread tissue dissemination of SARS-CoV-2 in individual monkeys and provide evidence for continuing virus replication in lungs and surrounding lymph nodes after alleged convalescence of infection.
References: PMID: 34452537 / doi: 10.3390/v13081673
Contact Info: Ernst Verschoor: [email protected]
URL: https://www.mdpi.com/1999-4915/13/8/1673
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre (BPRC); Eurofins-INGENASA; Erasmus University Medical Center; Utrecht University
Keywords: SARS-CoV-2, post-acute phase, immune response, tomography, virus replication, primates
Summary of Study: NHPs infected with SARS-CoV-2 were followed for up to 6 weeks and monitored for COVID-19-like disease symptoms. Data indicate widespread tissue dissemination of SARS-CoV-2 in individual monkeys and provide evidence for continuing virus replication in lungs and surrounding lymph nodes after alleged convalescence of infection.
References: PMID: 34452537 / doi: 10.3390/v13081673
Contact Info: Ernst Verschoor: [email protected]
URL: https://www.mdpi.com/1999-4915/13/8/1673
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Battelle National Biodefense Institute; Gryphon Scientific LLC, Censeo Insight; Applied Research Associates
Keywords: SARS-CoV-2, inhalation, infection route, virus detection, dose response, primates
Summary of Study: SARS-CoV-2 infection and subsequent disease presentation are dependent on exposure dose in a nonhuman primate model of inhalational COVID-19.
References: PMID: 34424943 / doi: 10.1371/journal.ppat.1009865
Contact Info: Paul Dabisch: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009865
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Battelle National Biodefense Institute; Gryphon Scientific LLC, Censeo Insight; Applied Research Associates
Keywords: SARS-CoV-2, inhalation, infection route, virus detection, dose response, primates
Summary of Study: SARS-CoV-2 infection and subsequent disease presentation are dependent on exposure dose in a nonhuman primate model of inhalational COVID-19.
References: PMID: 34424943 / doi: 10.1371/journal.ppat.1009865
Contact Info: Paul Dabisch: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009865
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; Harvard T.H. Chan School of Public Health; Emory University; Moderna, Bioqual
Keywords: SARS-CoV-2, RNA-vaccine, immune response, virus replication, protection, primates
Summary of Study: Data establish that a two-dose regimen of mRNA-1273 (Moderna vaccine) will be critical for providing upper and lower airway protection against major variants of concern.
References: PMID: 34417590 / doi: 10.1038/s41590-021-02021-0
Contact Info: Barney Graham: [email protected]; Robert Seder: [email protected]
URL: https://www.nature.com/articles/s41590-021-01021-0
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; Harvard T.H. Chan School of Public Health; Emory University; Moderna, Bioqual
Keywords: SARS-CoV-2, RNA-vaccine, immune response, virus replication, protection, primates
Summary of Study: Data establish that a two-dose regimen of mRNA-1273 (Moderna vaccine) will be critical for providing upper and lower airway protection against major variants of concern.
References: PMID: 34417590 / doi: 10.1038/s41590-021-02021-0
Contact Info: Barney Graham: [email protected]; Robert Seder: [email protected]
URL: https://www.nature.com/articles/s41590-021-01021-0
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: The Wistar Institute, Perelman School of Medicine, NIAID, and others
Keywords: MERS-CoV, intradermal and intramuscular delivery, synthetic DNA vaccine, primates
Summary of Study: Results illustrate that a MERS spike antigen synthetic DNA vaccine administered in a 2-dose i.d. EP regimen can have positive impact in an important NHP challenge model protecting against symptoms and pathology.
References: PMID: 33886507 / doi: 10.1172/jci.insight.146082
Contact Info: David Weiner: [email protected]
URL: https://insight.jci.org/articles/view/146082
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: The Wistar Institute, Perelman School of Medicine, NIAID, and others
Keywords: MERS-CoV, intradermal and intramuscular delivery, synthetic DNA vaccine, primates
Summary of Study: Results illustrate that a MERS spike antigen synthetic DNA vaccine administered in a 2-dose i.d. EP regimen can have positive impact in an important NHP challenge model protecting against symptoms and pathology.
References: PMID: 33886507 / doi: 10.1172/jci.insight.146082
Contact Info: David Weiner: [email protected]
URL: https://insight.jci.org/articles/view/146082
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Public Health England & Welcome Trust Centre for Human Genetics
Keywords: SARS-CoV-2, pathogenicity, comparative studies, primates
Summary of Study: SARS-CoV-2 replicates in the upper and lower respiratory tract and causes pulmonary lesions in both rhesus and cynomolgus macaques. This provides convincing evidence that both macaque species authentically represent mild to moderate forms of COVID-19 observed in the majority of the human populations and both species can e used to evaluate the safety and efficacy of interventions proposed against SARS-CoV-2. Importantly, accessing cynomolgus macaques will greatly alleviate the pressures on current rhesus stocks.
References: PMID: 33627662 / doi: 10.1038/s41467-021-21389-9
Contact Info: Miles Carroll: [email protected]
URL: https://www.nature.com/articles/s41467-021-21389-9
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Public Health England & Welcome Trust Centre for Human Genetics
Keywords: SARS-CoV-2, pathogenicity, comparative studies, primates
Summary of Study: SARS-CoV-2 replicates in the upper and lower respiratory tract and causes pulmonary lesions in both rhesus and cynomolgus macaques. This provides convincing evidence that both macaque species authentically represent mild to moderate forms of COVID-19 observed in the majority of the human populations and both species can e used to evaluate the safety and efficacy of interventions proposed against SARS-CoV-2. Importantly, accessing cynomolgus macaques will greatly alleviate the pressures on current rhesus stocks.
References: PMID: 33627662 / doi: 10.1038/s41467-021-21389-9
Contact Info: Miles Carroll: [email protected]
URL: https://www.nature.com/articles/s41467-021-21389-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Wheaten College, Cornell University
Keywords: SARS-CoV-2, virus susceptibility, animal welfare, hamsters, ferrets, primates
Summary of Study: Paper reviews virus susceptibilities in species with frequent human contact, and factors that are best predictors of virus susceptibility.
References: PMID: 34359172 / doi: 10.3390/ani11072044
Contact Info: Kathleen Morgan: [email protected]
URL: https://www.mdpi.com/2076-2615/11/7/2044
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Wheaten College, Cornell University
Keywords: SARS-CoV-2, virus susceptibility, animal welfare, hamsters, ferrets, primates
Summary of Study: Paper reviews virus susceptibilities in species with frequent human contact, and factors that are best predictors of virus susceptibility.
References: PMID: 34359172 / doi: 10.3390/ani11072044
Contact Info: Kathleen Morgan: [email protected]
URL: https://www.mdpi.com/2076-2615/11/7/2044
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP, NIH
Keywords: SARS-CoV-2, the use of primates for COVID research, animal resources
Summary of Study: The SARS-CoV-2/COVID-19 pandemic has significantly increased the demand for specific-pathogen-free (SFP) NHPs for development of vaccines and therapeutics. Non-SPF animals, which are available in greater numbers and include well-characterized primate species, should be considered in lieu of limited SPF animals for appropriate research studies.
References: doi: 10.1038/s41684-021-00810-2
Contact Info: Miguel Contreras: miguel.contreras
URL: https://www.nature.com/articles/s41684-021-00810-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP, NIH
Keywords: SARS-CoV-2, the use of primates for COVID research, animal resources
Summary of Study: The SARS-CoV-2/COVID-19 pandemic has significantly increased the demand for specific-pathogen-free (SFP) NHPs for development of vaccines and therapeutics. Non-SPF animals, which are available in greater numbers and include well-characterized primate species, should be considered in lieu of limited SPF animals for appropriate research studies.
References: doi: 10.1038/s41684-021-00810-2
Contact Info: Miguel Contreras: miguel.contreras
URL: https://www.nature.com/articles/s41684-021-00810-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Statens Serum Institute; Robert Koch Institute; BIOQUAL; University of Southern Denmark
Keywords: SARS-CoV-2, DNA plasmid vaccine, immune response, primates
Summary of Study: The candidate plasmid DNA vaccine encoding the SARS-CoV-2 spike protein is immunogenic in different models and confers protection against lung infection in nonhuman primates. Further evaluation of this DNA vaccine candidate in clinical trials is warranted.
References: PMID: 34930909 / doi: 10.1038/s41541-021-00419-z
Contact Info: Anders Fomsgaard: [email protected]
URL: https://www.nature.com/articles/s41541-021-00419-z
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Statens Serum Institute; Robert Koch Institute; BIOQUAL; University of Southern Denmark
Keywords: SARS-CoV-2, DNA plasmid vaccine, immune response, primates
Summary of Study: The candidate plasmid DNA vaccine encoding the SARS-CoV-2 spike protein is immunogenic in different models and confers protection against lung infection in nonhuman primates. Further evaluation of this DNA vaccine candidate in clinical trials is warranted.
References: PMID: 34930909 / doi: 10.1038/s41541-021-00419-z
Contact Info: Anders Fomsgaard: [email protected]
URL: https://www.nature.com/articles/s41541-021-00419-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: tamarins, marmosets, howler monkeys, titi monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Faculdade de Medicina de Sao Jose do Rio Preto, Brazil; Fundacao de Medicina Tropical Doutor Heitor Vieria Dourado, Brazil; Universidade do Estado do Amazonas, Brazil; Universidade Federal do Amazonas, Brazil; Universidade de Sao Paulo, Brazil; Hospital Israelita Albert Einstein; Instituto Butanta; Departamento de Vigilancia Epidemiologica de Sao Jose do Rio Preto; New Mexico State University; The University of Texas Medical Branch, Galveston; Instituto Leonidas e Maria Deane, Brazil
Keywords: SARS-CoV-2, wild animals, molecular and serological tests, primates
Summary of Study: Although no evidence of SARS-CoV-2 infection was detected, continued surveillance of NHPs in this region is warranted and may identify geographic areas or particular NHP species prone to spillover.
References: PMID: 34696363 / doi: 10.3390/v13101933
Contact Info: Marcus Vinicius Guimaraes de Lacerda: [email protected]; Mauricio Lacerda Nogueira: [email protected]
URL: https://www.mdpi.com/1999-4915/13/10/1933
NHP Species: tamarins, marmosets, howler monkeys, titi monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Faculdade de Medicina de Sao Jose do Rio Preto, Brazil; Fundacao de Medicina Tropical Doutor Heitor Vieria Dourado, Brazil; Universidade do Estado do Amazonas, Brazil; Universidade Federal do Amazonas, Brazil; Universidade de Sao Paulo, Brazil; Hospital Israelita Albert Einstein; Instituto Butanta; Departamento de Vigilancia Epidemiologica de Sao Jose do Rio Preto; New Mexico State University; The University of Texas Medical Branch, Galveston; Instituto Leonidas e Maria Deane, Brazil
Keywords: SARS-CoV-2, wild animals, molecular and serological tests, primates
Summary of Study: Although no evidence of SARS-CoV-2 infection was detected, continued surveillance of NHPs in this region is warranted and may identify geographic areas or particular NHP species prone to spillover.
References: PMID: 34696363 / doi: 10.3390/v13101933
Contact Info: Marcus Vinicius Guimaraes de Lacerda: [email protected]; Mauricio Lacerda Nogueira: [email protected]
URL: https://www.mdpi.com/1999-4915/13/10/1933
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center, Tulane University School of Medicine, Tulane University, Brigham and Women's Hospital/Harvard Medical School, LSU Health Science Center, Julius-Maximilians-Universitat Wurzburg, and more
Keywords: SARS-CoV-2, pulmonary vascular endotheliosis, perivascular inflammation, rodents and primates
Summary of Study: SARS-CoV-2 causes endotheliitis via both infection and infection-mediated immune activation, which may contribute to the pathogenesis of severe COVID-19 disease.
References: PMID: 34335981 / doi: 10.7150/thno.61810
Contact Info: Jay Kolls: [email protected]; Fengming Liu: [email protected]; Jay Rappaport: [email protected]
URL: https://www.thno.org/v11p8076.htm
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center, Tulane University School of Medicine, Tulane University, Brigham and Women's Hospital/Harvard Medical School, LSU Health Science Center, Julius-Maximilians-Universitat Wurzburg, and more
Keywords: SARS-CoV-2, pulmonary vascular endotheliosis, perivascular inflammation, rodents and primates
Summary of Study: SARS-CoV-2 causes endotheliitis via both infection and infection-mediated immune activation, which may contribute to the pathogenesis of severe COVID-19 disease.
References: PMID: 34335981 / doi: 10.7150/thno.61810
Contact Info: Jay Kolls: [email protected]; Fengming Liu: [email protected]; Jay Rappaport: [email protected]
URL: https://www.thno.org/v11p8076.htm
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences; Shenzhen Kangtai Biotechnology Co., Ltd.; Academy of Military Medical Sciences; Zhenzhou University; National Institutes for Food and Drug Control; Henan Normal University
Keywords: SARS-CoV-2, chimeric spike protein, humoral immune response, pathology, mice, primates
Summary of Study: The strategy of chimerica expression SARS-CoV-2 S RBD in SARS-CoV represents a new design for other vaccine platforms.
References: PMID: 34759261 / doi: 10.1038/s41392-021-00797-9
Contact Info: Shuguang Duo: [email protected]
URL: https://www.nature.com/articles/s41392-021-00797-9
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences; Shenzhen Kangtai Biotechnology Co., Ltd.; Academy of Military Medical Sciences; Zhenzhou University; National Institutes for Food and Drug Control; Henan Normal University
Keywords: SARS-CoV-2, chimeric spike protein, humoral immune response, pathology, mice, primates
Summary of Study: The strategy of chimerica expression SARS-CoV-2 S RBD in SARS-CoV represents a new design for other vaccine platforms.
References: PMID: 34759261 / doi: 10.1038/s41392-021-00797-9
Contact Info: Shuguang Duo: [email protected]
URL: https://www.nature.com/articles/s41392-021-00797-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Celltech Pharmed Co.; Iran University of Medical Sciences; University of Iran; Tarbiat Modares University; Royan Institute for Stem Cell Biology and Technology; and others
Keywords: SARS-CoV-2, mRNA-vaccine, lipid nanoparticle, spike protein, immune response, primates
Summary of Study: A novel mRNA-LNP vaccine against SARS-CoV-2 was developed and preclinically evaluated, revealing that it was efficient enough to induce high level production of neutralizing antibodies against SARS-CoV-2 in mice and rhesus macaque monkeys.
References: PMID: 34579244 / doi: 10.3390/vaccines9091007
Contact Info: Alireza Sohi: [email protected]; Jafar Kiani: [email protected]; Ehsan Arefian: [email protected]; Arezou Khosrojerdi: [email protected]; Mohammad Zim: [email protected]
URL: https://www.mdpi.com/2076-393X/9/9/1007
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Celltech Pharmed Co.; Iran University of Medical Sciences; University of Iran; Tarbiat Modares University; Royan Institute for Stem Cell Biology and Technology; and others
Keywords: SARS-CoV-2, mRNA-vaccine, lipid nanoparticle, spike protein, immune response, primates
Summary of Study: A novel mRNA-LNP vaccine against SARS-CoV-2 was developed and preclinically evaluated, revealing that it was efficient enough to induce high level production of neutralizing antibodies against SARS-CoV-2 in mice and rhesus macaque monkeys.
References: PMID: 34579244 / doi: 10.3390/vaccines9091007
Contact Info: Alireza Sohi: [email protected]; Jafar Kiani: [email protected]; Ehsan Arefian: [email protected]; Arezou Khosrojerdi: [email protected]; Mohammad Zim: [email protected]
URL: https://www.mdpi.com/2076-393X/9/9/1007
Coronavirus Investigated: SARS-CoV-2
NHP Species: lemurs, lorises
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Calgary; Institut de Biologia Evolutiva, Universitat Pompeu Fabra; North Carolina Central University, Duke University and others
Keywords: SARS-CoV-2, ACE2 gene and protein sequences, several species, primates
Summary of Study: Study suggests that lemurs of the families Indriidae, Daubentonlidae, and Lemuridae are likely to be particularly vulnerable to SARS-CoV-2 infection.
References: PMID: 33792947 / doi: 10.1002/ajp.23255
Contact Info: James Higham: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/ajp.23255
NHP Species: lemurs, lorises
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Calgary; Institut de Biologia Evolutiva, Universitat Pompeu Fabra; North Carolina Central University, Duke University and others
Keywords: SARS-CoV-2, ACE2 gene and protein sequences, several species, primates
Summary of Study: Study suggests that lemurs of the families Indriidae, Daubentonlidae, and Lemuridae are likely to be particularly vulnerable to SARS-CoV-2 infection.
References: PMID: 33792947 / doi: 10.1002/ajp.23255
Contact Info: James Higham: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/ajp.23255
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences
Keywords: SARS-CoV-2, virus entry mediated by ACE2, several species
Summary of Study: A natural isoform of the rhesus macaque ACE2 protein with the Y217N mutation was resistant to SARS-CoV-2 infection, highlighting the possible impact of this ACE2 mutation on SARS-CoV-2 studies in rhesus macaques. The authors also demonstrated that the Y217 residue of ACE2 is a critical determinant for the ability of ACE2 to mediate SARS-CoV-2 entry. The results of this study clarify that SARS-CoV-2 can use the ACE2 receptors of multiple animal species and show that tracking the natural reservoirs and intermediate hosts of SARS-CoV-2 is complex.
References: PMID: 33610551 / doi: 10.1016/j.jbc.2021.100435
Contact Info: Yan-Dong Tang: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0021925821002088?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences
Keywords: SARS-CoV-2, virus entry mediated by ACE2, several species
Summary of Study: A natural isoform of the rhesus macaque ACE2 protein with the Y217N mutation was resistant to SARS-CoV-2 infection, highlighting the possible impact of this ACE2 mutation on SARS-CoV-2 studies in rhesus macaques. The authors also demonstrated that the Y217 residue of ACE2 is a critical determinant for the ability of ACE2 to mediate SARS-CoV-2 entry. The results of this study clarify that SARS-CoV-2 can use the ACE2 receptors of multiple animal species and show that tracking the natural reservoirs and intermediate hosts of SARS-CoV-2 is complex.
References: PMID: 33610551 / doi: 10.1016/j.jbc.2021.100435
Contact Info: Yan-Dong Tang: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0021925821002088?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Russian Academy of Sciences, Sechenov First Moscow State Medical University, Lomonosov Moscow State University
Keywords: SARS-CoV-2, serology, neutralizing antibodies, immunogenicity, inactivated vaccine, primates
Summary of Study: A B-propiolactone-inactivated whole virion vaccine CoviVac was developed and assessed. The vaccine produced stable and robust humoral immune response in mice, Syrian hamsters and common marmosets.
References: PMID: 34427172 / doi: 10.1080/22221751.2021.1971569
Contact Info: Liubov Kozlovskaya: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1971569
NHP Species: marmosets
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Russian Academy of Sciences, Sechenov First Moscow State Medical University, Lomonosov Moscow State University
Keywords: SARS-CoV-2, serology, neutralizing antibodies, immunogenicity, inactivated vaccine, primates
Summary of Study: A B-propiolactone-inactivated whole virion vaccine CoviVac was developed and assessed. The vaccine produced stable and robust humoral immune response in mice, Syrian hamsters and common marmosets.
References: PMID: 34427172 / doi: 10.1080/22221751.2021.1971569
Contact Info: Liubov Kozlovskaya: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1971569
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, hamadryas baboons, marmosets
Year Published: 2021
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center, Texas Biomedical Research Institute, Regeneron, and others
Keywords: SARS-CoV-2, severe acute respiratory syndrome, young and old animals, primates
Summary of Study: Acute respiratory distress in macaques and baboons recapitulates the progression of COVID-19 in humans, making them suitable as models to test vaccines and therapies.
References: PMID: 33340034 / doi: 10.1038/s41564-020-00841-4
Contact Info: Deepak Kaushal: [email protected], Luis Giavedoni: [email protected]
URL: https://www.nature.com/articles/s41564-020-00841-4#Sec9
NHP Species: rhesus macaques, hamadryas baboons, marmosets
Year Published: 2021
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center, Texas Biomedical Research Institute, Regeneron, and others
Keywords: SARS-CoV-2, severe acute respiratory syndrome, young and old animals, primates
Summary of Study: Acute respiratory distress in macaques and baboons recapitulates the progression of COVID-19 in humans, making them suitable as models to test vaccines and therapies.
References: PMID: 33340034 / doi: 10.1038/s41564-020-00841-4
Contact Info: Deepak Kaushal: [email protected], Luis Giavedoni: [email protected]
URL: https://www.nature.com/articles/s41564-020-00841-4#Sec9
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Duke University School of Medicine, UNC Chapel Hill, NIAID, Harvard Medical School, and others
Keywords: SARS-CoV-2, neutralizing antibodies, immune response, primates
Summary of Study: In vitro infection-enhancing RBC and NTD ABs controlled virus in vito and was rarely associated with enhanced lung pathology.
References: PMID: 34242577 / doi: 10.1016/j.cell.2021.06.021
Contact Info: Barton Haynes (Duke University School of Medicine); Kevin Saunders (Duke University School of Medicine)
URL: https://www.sciencedirect.com/science/article/pii/S009286742100756X?via%3Dihub=
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Duke University School of Medicine, UNC Chapel Hill, NIAID, Harvard Medical School, and others
Keywords: SARS-CoV-2, neutralizing antibodies, immune response, primates
Summary of Study: In vitro infection-enhancing RBC and NTD ABs controlled virus in vito and was rarely associated with enhanced lung pathology.
References: PMID: 34242577 / doi: 10.1016/j.cell.2021.06.021
Contact Info: Barton Haynes (Duke University School of Medicine); Kevin Saunders (Duke University School of Medicine)
URL: https://www.sciencedirect.com/science/article/pii/S009286742100756X?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Sabzevar University of Medical Sciences, University of Edinburgh, Nagasaki University
Keywords: SARS-CoV-2, infective dose, several animal species, pathogenesis, primates
Summary of Study: This review focused on comparative infective dose studies for SARS-CoV-2, SARS-CoV-1, and MERS. The review suggests that the infective dose in humans is small, perhaps about 100 particles. Further work is required to understand the relationship between routes of transmission, infective dose, co-infection and outcomes.
References: PMID: 33849679 / doi: 10.1017/S0950268821000790
Contact Info: Sedighe Karimzadeh: [email protected]; Raj Bhopal: [email protected]
URL: https://www.cambridge.org/core/journals/epidemiology-and-infection/article/revi…
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Sabzevar University of Medical Sciences, University of Edinburgh, Nagasaki University
Keywords: SARS-CoV-2, infective dose, several animal species, pathogenesis, primates
Summary of Study: This review focused on comparative infective dose studies for SARS-CoV-2, SARS-CoV-1, and MERS. The review suggests that the infective dose in humans is small, perhaps about 100 particles. Further work is required to understand the relationship between routes of transmission, infective dose, co-infection and outcomes.
References: PMID: 33849679 / doi: 10.1017/S0950268821000790
Contact Info: Sedighe Karimzadeh: [email protected]; Raj Bhopal: [email protected]
URL: https://www.cambridge.org/core/journals/epidemiology-and-infection/article/revi…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Fudan University, Second Military Medical University, Peking University
Keywords: SARS-CoV-2, cell-based vaccine, neutralizing antibodies, immune response, pathology, mice, primates
Summary of Study: The data present strong evidence supporting the promise of K562-S (a novel cell-based vaccine candidate that uses human cell K562 as a cellular carrier to display Spike (S) protein on the membrane) as a new effective vaccine for the prevention of COVID-19.
References: PMID: 34304724 / doi: 10.1080/22221751.2021.1957400
Contact Info: Jianqing Xu: [email protected]; Xiaoyan Zhang: [email protected]; Chen Zhao: [email protected]; Ping Zhao: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1957400
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Fudan University, Second Military Medical University, Peking University
Keywords: SARS-CoV-2, cell-based vaccine, neutralizing antibodies, immune response, pathology, mice, primates
Summary of Study: The data present strong evidence supporting the promise of K562-S (a novel cell-based vaccine candidate that uses human cell K562 as a cellular carrier to display Spike (S) protein on the membrane) as a new effective vaccine for the prevention of COVID-19.
References: PMID: 34304724 / doi: 10.1080/22221751.2021.1957400
Contact Info: Jianqing Xu: [email protected]; Xiaoyan Zhang: [email protected]; Chen Zhao: [email protected]; Ping Zhao: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1957400
Coronavirus Investigated: SARS-CoV-2
NHP Species: olive baboons
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Novavax, University of Maryland, University of Oklahoma, and others
Keywords: SARS-CoV-2, subunit vaccine (NVX-CoV2373), mice and primates
Summary of Study: Administering a subunit vaccine (NVX-CoV2373) constructed from the full-length S-protein, with Matrix-M adjuvant in a nonhuman primate model induces B- and T-cell responses, hACE2-receptor-blocking antibodies, and SARS-CoV-2 neutralizing antibodies. These results support the clinical development of the NVX-C0V2373 vaccine for prevention of COVID-19.
References: PMID: 33446655 / doi: 10.1038/s41467-020-20653-8
Contact Info: Gale Smith: [email protected]
URL: https://www.nature.com/articles/s41467-020-20653-8
NHP Species: olive baboons
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Novavax, University of Maryland, University of Oklahoma, and others
Keywords: SARS-CoV-2, subunit vaccine (NVX-CoV2373), mice and primates
Summary of Study: Administering a subunit vaccine (NVX-CoV2373) constructed from the full-length S-protein, with Matrix-M adjuvant in a nonhuman primate model induces B- and T-cell responses, hACE2-receptor-blocking antibodies, and SARS-CoV-2 neutralizing antibodies. These results support the clinical development of the NVX-C0V2373 vaccine for prevention of COVID-19.
References: PMID: 33446655 / doi: 10.1038/s41467-020-20653-8
Contact Info: Gale Smith: [email protected]
URL: https://www.nature.com/articles/s41467-020-20653-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Indian Veterinary Research Institute and others
Keywords: SARS-CoV-2, domestic and wild animal species, public health
Summary of Study: This review analyzes the current evidence of SARS-CoV-2 natural infection in domestic and wild animal species and their possible implications on public health.
References: PMID: 33892621 / doi: 10.1080/01652176/2021.1921311
Contact Info: Khan Sharun: [email protected]; Kuldeep Dhama: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128218/pdf/TVEQ_41_1921311.pdf
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Indian Veterinary Research Institute and others
Keywords: SARS-CoV-2, domestic and wild animal species, public health
Summary of Study: This review analyzes the current evidence of SARS-CoV-2 natural infection in domestic and wild animal species and their possible implications on public health.
References: PMID: 33892621 / doi: 10.1080/01652176/2021.1921311
Contact Info: Khan Sharun: [email protected]; Kuldeep Dhama: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128218/pdf/TVEQ_41_1921311.pdf
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Texas Medical Branch
Keywords: SARS-CoV-2, convalescent sera, primates
Summary of Study: Convalescent plasma therapy in humans may be an effective strategy provided that donor sera contain high anti-SARS-CoV-2 neutralizing titers given in early states of the disease.
References: PMID: 33662255 / doi: 10.1016/j.celrep.2021.108837
Contact Info: Thomas W. Geisbert:
URL: https://www.sciencedirect.com/science/article/pii/S2211124721001510?via%3Dihub=
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Texas Medical Branch
Keywords: SARS-CoV-2, convalescent sera, primates
Summary of Study: Convalescent plasma therapy in humans may be an effective strategy provided that donor sera contain high anti-SARS-CoV-2 neutralizing titers given in early states of the disease.
References: PMID: 33662255 / doi: 10.1016/j.celrep.2021.108837
Contact Info: Thomas W. Geisbert:
URL: https://www.sciencedirect.com/science/article/pii/S2211124721001510?via%3Dihub=