Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: The Wistar Institute; Inovio Pharmaceuticals; Bioqual
Keywords: SARS-CoV-2, DNA vaccine, immunogenicity, immune response, adaptive immune response, primates
Summary of Study: INO-4800, an intradermal-delivered SARS-CoV-2 spike DNA vaccine, induced both humoral and cellular arms of the adaptive immune system.
References: PMID: 34604818 / doi: 10.1016/j.xcrm.2021.100420
Contact Info: Kate Broderick: [email protected]; David Weiner: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379121002822?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: The Wistar Institute; Inovio Pharmaceuticals; Bioqual
Keywords: SARS-CoV-2, DNA vaccine, immunogenicity, immune response, adaptive immune response, primates
Summary of Study: INO-4800, an intradermal-delivered SARS-CoV-2 spike DNA vaccine, induced both humoral and cellular arms of the adaptive immune system.
References: PMID: 34604818 / doi: 10.1016/j.xcrm.2021.100420
Contact Info: Kate Broderick: [email protected]; David Weiner: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379121002822?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Shiga University of Medical Science, Otsu, Japan
Keywords: SARS-CoV-2, severe acute respiratory syndrome, immune response, primates
Summary of Study: Cynomolgus macaques infected with SARS-CoV-2 showed body temperature rises and X-ray radiographic pneumonia without life-threatening clinical signs of disease. Because of similar symptoms to approximately 80% of patients, cynomolgus macaques are appropriate to extrapolate the efficacy of vaccines and antiviral drugs for humans.
References: PMID: 33412411/doi: 10.1016/j.virol.2020.12.013
Contact Info: Yasushi Itoh (no contact information)
URL: https://www.sciencedirect.com/science/article/pii/S0042682220302609?via%3Dihub=
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Shiga University of Medical Science, Otsu, Japan
Keywords: SARS-CoV-2, severe acute respiratory syndrome, immune response, primates
Summary of Study: Cynomolgus macaques infected with SARS-CoV-2 showed body temperature rises and X-ray radiographic pneumonia without life-threatening clinical signs of disease. Because of similar symptoms to approximately 80% of patients, cynomolgus macaques are appropriate to extrapolate the efficacy of vaccines and antiviral drugs for humans.
References: PMID: 33412411/doi: 10.1016/j.virol.2020.12.013
Contact Info: Yasushi Itoh (no contact information)
URL: https://www.sciencedirect.com/science/article/pii/S0042682220302609?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane NPRC, North Carolina State University
Keywords: SARS-CoV-2, portable, ultrasensitive saliva-based virus assay, primates
Summary of Study: CRISPR-FDS determined that mean SARS-Cov-2 RNA levels were 3.6 fold to 124-fold higher, and more stable, in oropharyngeal versus nasal swab samples from nonhuman primates at all time points after infection, suggesting that saliva may represent a more robust diagnostic sample than nasal swabs both early and later in infection.
References: PMID: 33310733 / doi: 10.1126/sciadv.abe3703
Contact Info: Tony Hu: [email protected]
URL: https://advances.sciencemag.org/content/7/2/eabe3703
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane NPRC, North Carolina State University
Keywords: SARS-CoV-2, portable, ultrasensitive saliva-based virus assay, primates
Summary of Study: CRISPR-FDS determined that mean SARS-Cov-2 RNA levels were 3.6 fold to 124-fold higher, and more stable, in oropharyngeal versus nasal swab samples from nonhuman primates at all time points after infection, suggesting that saliva may represent a more robust diagnostic sample than nasal swabs both early and later in infection.
References: PMID: 33310733 / doi: 10.1126/sciadv.abe3703
Contact Info: Tony Hu: [email protected]
URL: https://advances.sciencemag.org/content/7/2/eabe3703
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: NCI/NIH
Keywords: SARS-CoV-2, ACE2, type I interferon, pathology, primates
Summary of Study: Type I interferon mediates an important innate immune response against viral infection by directly inhibiting viral replication. It also bridges innate to adaptive immunity for long-term protection against viral reinfections.
References: PMID: 34149696 / doi: 10.3389/fimmu.2021.658428
Contact Info: Yongjun Sui: [email protected]; Jay Berzofsky: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.658428/full
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: NCI/NIH
Keywords: SARS-CoV-2, ACE2, type I interferon, pathology, primates
Summary of Study: Type I interferon mediates an important innate immune response against viral infection by directly inhibiting viral replication. It also bridges innate to adaptive immunity for long-term protection against viral reinfections.
References: PMID: 34149696 / doi: 10.3389/fimmu.2021.658428
Contact Info: Yongjun Sui: [email protected]; Jay Berzofsky: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.658428/full
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Amsterdam; University Paris-Saclay, Inserm, CEA; AIMM Therapeutics BV; J&S Preclinical Solutions; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, variants of concern, third vaccination, mice, rabbits, primates
Summary of Study: A third immunization improves neutralizing antibody titers against the variants-of-concern (Alpha, Beta, Gamma, and Delta).
References: PMID: 34862406 / doi: 10.1038/s41541-021-00411-7
Contact Info: Rogier Sanders: [email protected]
URL: https://www.nature.com/articles/s41541-021-00411-7
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Amsterdam; University Paris-Saclay, Inserm, CEA; AIMM Therapeutics BV; J&S Preclinical Solutions; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, variants of concern, third vaccination, mice, rabbits, primates
Summary of Study: A third immunization improves neutralizing antibody titers against the variants-of-concern (Alpha, Beta, Gamma, and Delta).
References: PMID: 34862406 / doi: 10.1038/s41541-021-00411-7
Contact Info: Rogier Sanders: [email protected]
URL: https://www.nature.com/articles/s41541-021-00411-7
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: National Primate Research Centre, Republic of Korea; Chonnam National University; Korea Cancer Center Hospital; University of Ulsan College of Medicine; Futuristic Animal Resource Centre; Seoul National University; Korea University of Science & Technology; and others.
Keywords: SARS-CoV-2, germinal centers, viral reinfection, lung damage, primates
Summary of Study: The seroconversion observed in macaques, which recapitulates the course of COVID-19 disease in human survivors with mild or moderate symptoms, was consistent with the response of GCs in lymphoid tissues and blood of the human subjects tested.
References: PMID: 34718664 / doi: 10.1093/infdis/jiab535
Contact Info: Jung Joo Hong: [email protected]
URL: https://academic.oup.com/jid/article/224/11/1861/6413652
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: National Primate Research Centre, Republic of Korea; Chonnam National University; Korea Cancer Center Hospital; University of Ulsan College of Medicine; Futuristic Animal Resource Centre; Seoul National University; Korea University of Science & Technology; and others.
Keywords: SARS-CoV-2, germinal centers, viral reinfection, lung damage, primates
Summary of Study: The seroconversion observed in macaques, which recapitulates the course of COVID-19 disease in human survivors with mild or moderate symptoms, was consistent with the response of GCs in lymphoid tissues and blood of the human subjects tested.
References: PMID: 34718664 / doi: 10.1093/infdis/jiab535
Contact Info: Jung Joo Hong: [email protected]
URL: https://academic.oup.com/jid/article/224/11/1861/6413652
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Yerkes National Primate Research Center/Emory University; Emory School of Medicine; Ragon Institute of MGH, MIT and Harvard; The University of Texas Medical Branch; 3M Corporate Research Materials Laboratory; and others.
Keywords: SARS-CoV-2, receptor-binding domain subunit vaccine, neutralizing antibody, immune response, primates
Summary of Study: This study demonstrated the potential benefits of RBD trimer as an immunogen for COVID-19 vaccine using mice and macaque models. Future studies will investigate the durability of the vaccine-induced immune responses and what parameters lead to protection.
References: PMID: 34117252 / doi: 10.1038/s41467-021-23942-y
Contact Info: Rama Rao Amara: [email protected]
URL: https://www.nature.com/articles/s41467-021-23942-y
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Yerkes National Primate Research Center/Emory University; Emory School of Medicine; Ragon Institute of MGH, MIT and Harvard; The University of Texas Medical Branch; 3M Corporate Research Materials Laboratory; and others.
Keywords: SARS-CoV-2, receptor-binding domain subunit vaccine, neutralizing antibody, immune response, primates
Summary of Study: This study demonstrated the potential benefits of RBD trimer as an immunogen for COVID-19 vaccine using mice and macaque models. Future studies will investigate the durability of the vaccine-induced immune responses and what parameters lead to protection.
References: PMID: 34117252 / doi: 10.1038/s41467-021-23942-y
Contact Info: Rama Rao Amara: [email protected]
URL: https://www.nature.com/articles/s41467-021-23942-y
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: EcoHealth Alliance; Deakin University; Institute of Epidemiology, Disease Control and Research (Dhaka, Bangladesh); University of Dhaka; Chattogram Veterinary and Animal Sciences University
Keywords: SARS-CoV-2, meta analysis, virus transmission, public health, susceptible animal species, primates
Summary of Study: The continuing spillover and spillback of SARS-CoV-2 in a wide range of animals in farming, captive and free-ranging interfaces make inferences for human and animal health, welfare and conservation. Pets, farmed and captive wild animals should be vaccinated in accordance with vaccination in humans.
References: PMID: 34694705 / doi: 10.111/tbed.14356
Contact Info: Ariful Islam: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1111/tbed.14356
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: EcoHealth Alliance; Deakin University; Institute of Epidemiology, Disease Control and Research (Dhaka, Bangladesh); University of Dhaka; Chattogram Veterinary and Animal Sciences University
Keywords: SARS-CoV-2, meta analysis, virus transmission, public health, susceptible animal species, primates
Summary of Study: The continuing spillover and spillback of SARS-CoV-2 in a wide range of animals in farming, captive and free-ranging interfaces make inferences for human and animal health, welfare and conservation. Pets, farmed and captive wild animals should be vaccinated in accordance with vaccination in humans.
References: PMID: 34694705 / doi: 10.111/tbed.14356
Contact Info: Ariful Islam: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1111/tbed.14356
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Tulane University Information Technology
Keywords: SARS-CoV-2, whole-blood transcriptome profiling, primates
Summary of Study: Hallmark similarities and differences in the RM and AGM acute response to SARS-CoV-2 infection were discovered and may help guide the selection of particular NHP species in modeling aspects of COVID-19 disease outcome.
References: PMID: 34691074 / doi: 10.3389/fimmu.2021.754642
Contact Info: Joseph Mudd: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.754642/full
NHP Species: african green monkeys, rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Tulane University Information Technology
Keywords: SARS-CoV-2, whole-blood transcriptome profiling, primates
Summary of Study: Hallmark similarities and differences in the RM and AGM acute response to SARS-CoV-2 infection were discovered and may help guide the selection of particular NHP species in modeling aspects of COVID-19 disease outcome.
References: PMID: 34691074 / doi: 10.3389/fimmu.2021.754642
Contact Info: Joseph Mudd: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.754642/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Columbia University, University of Texas Medical Branch, Case Western Reserve School of Medicine, and others
Keywords: SARS-CoV-2, peptide-based vaccine targeting MHC class I epitopes, immune response, pathology, primates
Summary of Study: A room temperature stable peptide vaccine based on known immunogenic HLA class I bound CTL epitopes from the nucleocapsid protein can provide protection against SARS-CoV-2 infection in nonhuman primates.
References: PMID: 34070152 / doi: 10.3390/vaccines9050520
Contact Info: Jason Comer: [email protected]; Reid Rubsamen: [email protected]
URL: https://www.mdpi.com/2076-393X/9/5/520
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Columbia University, University of Texas Medical Branch, Case Western Reserve School of Medicine, and others
Keywords: SARS-CoV-2, peptide-based vaccine targeting MHC class I epitopes, immune response, pathology, primates
Summary of Study: A room temperature stable peptide vaccine based on known immunogenic HLA class I bound CTL epitopes from the nucleocapsid protein can provide protection against SARS-CoV-2 infection in nonhuman primates.
References: PMID: 34070152 / doi: 10.3390/vaccines9050520
Contact Info: Jason Comer: [email protected]; Reid Rubsamen: [email protected]
URL: https://www.mdpi.com/2076-393X/9/5/520
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Southern Medical University, Shenzhen; Guangzhou Center for Disease Control and Prevention
Keywords: SARS-CoV-2, adenovirus vectored COVID-19 vaccine, immune response, pathology, primates
Summary of Study: Prime-boost immunization with Sad23L-nCoV-S and Ad49L-nCoV-S (both carrying the full-length of SARS-CoV-2 spike protein gene) can safely elicit strong immunity in animals.
References: PMID: 33993845 / doi: 10.1080/22221751.2021.1931466
Contact Info: Yuming Zhang: [email protected]; Tingting Li: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1931466
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Southern Medical University, Shenzhen; Guangzhou Center for Disease Control and Prevention
Keywords: SARS-CoV-2, adenovirus vectored COVID-19 vaccine, immune response, pathology, primates
Summary of Study: Prime-boost immunization with Sad23L-nCoV-S and Ad49L-nCoV-S (both carrying the full-length of SARS-CoV-2 spike protein gene) can safely elicit strong immunity in animals.
References: PMID: 33993845 / doi: 10.1080/22221751.2021.1931466
Contact Info: Yuming Zhang: [email protected]; Tingting Li: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1931466
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Korea Advanced Institute of Science & Technology, GENOME INSIGHT, INC.
Keywords: SARS-CoV-2, infection models, organoids, primates
Summary of Study: Review of in vitro and in vivo models for SARS-CoV-2 infection.
References: PMID: 34187969 / doi: 10.14348/molcells.2021.0094
Contact Info: Young Seok Ju: [email protected]
URL: https://www.molcells.org/journal/view.html?doi=10.14348/molcells.2021.0094
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Korea Advanced Institute of Science & Technology, GENOME INSIGHT, INC.
Keywords: SARS-CoV-2, infection models, organoids, primates
Summary of Study: Review of in vitro and in vivo models for SARS-CoV-2 infection.
References: PMID: 34187969 / doi: 10.14348/molcells.2021.0094
Contact Info: Young Seok Ju: [email protected]
URL: https://www.molcells.org/journal/view.html?doi=10.14348/molcells.2021.0094
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NCI/NIH; University of Maryland, BIOQUAL, NIAID and others
Keywords: SARS-CoV-2, adjuvanted subunit vaccines, immune response, primates
Summary of Study: Mucosal vaccine efficiently cleared virus in the nasal cavity and may act as a potent complementary reinforcing boost for conventional systemic vaccines to provide overall better protection.
References: PMID: 33908897 / doi: 10.1172/jci.insight.148494
Contact Info: Yongjun Sui: [email protected]; Jay Berzofsky: [email protected]
URL: https://insight.jci.org/articles/view/148494
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NCI/NIH; University of Maryland, BIOQUAL, NIAID and others
Keywords: SARS-CoV-2, adjuvanted subunit vaccines, immune response, primates
Summary of Study: Mucosal vaccine efficiently cleared virus in the nasal cavity and may act as a potent complementary reinforcing boost for conventional systemic vaccines to provide overall better protection.
References: PMID: 33908897 / doi: 10.1172/jci.insight.148494
Contact Info: Yongjun Sui: [email protected]; Jay Berzofsky: [email protected]
URL: https://insight.jci.org/articles/view/148494
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Clover Biopharmaceuticals, Kunming Institute of Zoology
Keywords: SARS-CoV-2, S-Trimer, subunit vaccine candidate, immunogenicity, efficacy, primates
Summary of Study: Rhesus macaques immunized with adjuvanted S-Trimer were protected from SARS-CoV-2 challenge. Trimer-Tag may be an important platform technology for scalable production and rapid development of safe and effective subunit vaccines against current and future emerging RNA viruses.
References: PMID: 33649323 / doi: 10.1038/s41467-021-21634-1
Contact Info: Peng Liang: [email protected]
URL: https://www.nature.com/articles/s41467-021-21634-1
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Clover Biopharmaceuticals, Kunming Institute of Zoology
Keywords: SARS-CoV-2, S-Trimer, subunit vaccine candidate, immunogenicity, efficacy, primates
Summary of Study: Rhesus macaques immunized with adjuvanted S-Trimer were protected from SARS-CoV-2 challenge. Trimer-Tag may be an important platform technology for scalable production and rapid development of safe and effective subunit vaccines against current and future emerging RNA viruses.
References: PMID: 33649323 / doi: 10.1038/s41467-021-21634-1
Contact Info: Peng Liang: [email protected]
URL: https://www.nature.com/articles/s41467-021-21634-1
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Iowa; University of Florida
Keywords: SARS-CoV-2, meta analysis, airway mucus, mucin glycoproteins, inflammation, primates
Summary of Study: Ferrets, nonhuman primates, and cats may have advantages over other models to investigate mucus in COVID-19.
References: PMID: 34794359 / doi: 10.1177/03009858211058837
Contact Info: not available
URL: https://journals.sagepub.com/doi/10.1177/03009858211058837?url_ver=Z39.88-2003&…
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Iowa; University of Florida
Keywords: SARS-CoV-2, meta analysis, airway mucus, mucin glycoproteins, inflammation, primates
Summary of Study: Ferrets, nonhuman primates, and cats may have advantages over other models to investigate mucus in COVID-19.
References: PMID: 34794359 / doi: 10.1177/03009858211058837
Contact Info: not available
URL: https://journals.sagepub.com/doi/10.1177/03009858211058837?url_ver=Z39.88-2003&…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Emory University School of Medicine
Keywords: SARS-CoV-2, several animal species, anti-viral therapeutic, vaccine development, primates
Summary of Study: Summarizing key features, strengths and weaknesses of animal models for SARS-CoV-2, focusing on their application in anti-viral therapeutic and vaccine development.
References: PMID: 33906125 / doi: 10.1016/j.coviro.2021.03.009
Contact Info: Anice Lowen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1879625721000316?via%3Dihub=
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Emory University School of Medicine
Keywords: SARS-CoV-2, several animal species, anti-viral therapeutic, vaccine development, primates
Summary of Study: Summarizing key features, strengths and weaknesses of animal models for SARS-CoV-2, focusing on their application in anti-viral therapeutic and vaccine development.
References: PMID: 33906125 / doi: 10.1016/j.coviro.2021.03.009
Contact Info: Anice Lowen: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1879625721000316?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chungbuk National University
Keywords: SARS-CoV-2, several animal species, transduction, pathology, primates
Summary of Study: Review of various animal models employed for SARS-CoV-2 infection studies that outlines their individual strengths and limitations for use in studies aimed at increasing understanding of coronavirus pathogenesis.
References: PMID: 33996168 / doi: 10.4110/in.2021.21.e12
Contact Info: Young Ki Choi: [email protected]
URL: https://immunenetwork.org/DOIx.php?id=10.4110/in.2021.21.e12
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chungbuk National University
Keywords: SARS-CoV-2, several animal species, transduction, pathology, primates
Summary of Study: Review of various animal models employed for SARS-CoV-2 infection studies that outlines their individual strengths and limitations for use in studies aimed at increasing understanding of coronavirus pathogenesis.
References: PMID: 33996168 / doi: 10.4110/in.2021.21.e12
Contact Info: Young Ki Choi: [email protected]
URL: https://immunenetwork.org/DOIx.php?id=10.4110/in.2021.21.e12
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, cryopreservation, resources, genetic diversity, primates
Summary of Study: The importance of rhesus macaques as a preclinical model for human diseases and treatment outcomes supports the development of improved cryopreservation methods and routine storage of gametes and embryos.
References: PMID: 34031599 / doi: 10.1038/s41684-021-00792-1
Contact Info: Matthew Arnegard: [email protected]
URL: https://www.nature.com/articles/s41684-021-00792-1
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, cryopreservation, resources, genetic diversity, primates
Summary of Study: The importance of rhesus macaques as a preclinical model for human diseases and treatment outcomes supports the development of improved cryopreservation methods and routine storage of gametes and embryos.
References: PMID: 34031599 / doi: 10.1038/s41684-021-00792-1
Contact Info: Matthew Arnegard: [email protected]
URL: https://www.nature.com/articles/s41684-021-00792-1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Akston Biosciences Corp.; Biomere Biomedical Research Models; Feigin ABSL-3 Facility, Baylor College of Medicine; BIOQUAL; California National Primate Research Center; Sinclair Research Center; Pharmaceutical Research Associates Group B.V.
Keywords: SARS-CoV-2, viral spike protein, immunogenicity, prophylaxis, Fc-fusion, mice, primates
Summary of Study: Preclinical studies support the initiation of Phase I clinical studies with adjuvanted AKS-452 with the expectation that this room-temperature stable, Fc-fusion subunit vaccine can be rapidly and inexpensively manufactured to provide billions of doses per year especially in regions where the cold-chain is difficult to maintain.
References: PMID: 34642088 / doi: 10.1016/j.vaccine.2021.09.077
Contact Info: Todd Zion: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21012949?via%3Dihub=
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Akston Biosciences Corp.; Biomere Biomedical Research Models; Feigin ABSL-3 Facility, Baylor College of Medicine; BIOQUAL; California National Primate Research Center; Sinclair Research Center; Pharmaceutical Research Associates Group B.V.
Keywords: SARS-CoV-2, viral spike protein, immunogenicity, prophylaxis, Fc-fusion, mice, primates
Summary of Study: Preclinical studies support the initiation of Phase I clinical studies with adjuvanted AKS-452 with the expectation that this room-temperature stable, Fc-fusion subunit vaccine can be rapidly and inexpensively manufactured to provide billions of doses per year especially in regions where the cold-chain is difficult to maintain.
References: PMID: 34642088 / doi: 10.1016/j.vaccine.2021.09.077
Contact Info: Todd Zion: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21012949?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: ReiThera Srl, University of Nottingham, National Institute for Infectious Diseases "Lazzaro Spallanzani"
Keywords: SARS-CoV-2, replication-defective gorilla adenovirus-vectored vaccine, immune response, mice and primates
Summary of Study: Pre-fusion stabilized Spike antigen is superior to the wild type in inducing ACE2-interfering, SARS-CoV-2-neutralizing antibodies.
References: PMID: 33895322 / doi: 10.1016/j.ymthe.2021.04.022
Contact Info: Alessandra Vitelli: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1525001621002100?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: ReiThera Srl, University of Nottingham, National Institute for Infectious Diseases "Lazzaro Spallanzani"
Keywords: SARS-CoV-2, replication-defective gorilla adenovirus-vectored vaccine, immune response, mice and primates
Summary of Study: Pre-fusion stabilized Spike antigen is superior to the wild type in inducing ACE2-interfering, SARS-CoV-2-neutralizing antibodies.
References: PMID: 33895322 / doi: 10.1016/j.ymthe.2021.04.022
Contact Info: Alessandra Vitelli: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1525001621002100?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Duke University School of Medicine, University of North Carolina at Chapel Hill, FDA, and others
Keywords: SARS-CoV-2, nanoparticles, receptor-binding domain of SARS-CoV-2, immune response, primates
Summary of Study: The immunization of macaques with nanoparticles conjugated with the receptor-binding domain of SARS-CoV-2, and adjuvanted with 3M-052 and alum, elicits cross-neutralizing antibody responses against bat coronaviruses, SARS-CoV and SARS-CoV-2. Nucleoside-modified mRNAs that encode a stabilized transmembrane spike or monomeric receptor-binding domain also induced cross-neutralizing antibody responses against SARS-CoV and bat coronaviruses.
References: PMID: 33971664 / doi: 10.1038/s41586-021-03594-0
Contact Info: Kevin Saunders: [email protected]; Barton Haynes: [email protected]
URL: https://www.nature.com/articles/s41586-021-03594-0
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Duke University School of Medicine, University of North Carolina at Chapel Hill, FDA, and others
Keywords: SARS-CoV-2, nanoparticles, receptor-binding domain of SARS-CoV-2, immune response, primates
Summary of Study: The immunization of macaques with nanoparticles conjugated with the receptor-binding domain of SARS-CoV-2, and adjuvanted with 3M-052 and alum, elicits cross-neutralizing antibody responses against bat coronaviruses, SARS-CoV and SARS-CoV-2. Nucleoside-modified mRNAs that encode a stabilized transmembrane spike or monomeric receptor-binding domain also induced cross-neutralizing antibody responses against SARS-CoV and bat coronaviruses.
References: PMID: 33971664 / doi: 10.1038/s41586-021-03594-0
Contact Info: Kevin Saunders: [email protected]; Barton Haynes: [email protected]
URL: https://www.nature.com/articles/s41586-021-03594-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID; Emory University; BIOQUAL, Inc.; Moderna, Inc.; Johns Hopkins University
Keywords: SARS-CoV-2, virus genomic variants, boost, immune response, primates
Summary of Study: Homologous mRNA-1273 boost can significantly improve both the breadth and potency of neutralizing antibody responses and confer protection against upper and lower airway infection to a heterologous challenge virus, which is relatively resistant to in vitro neutralization.
References: PMID: 34672695 / doi: 10.1126/science.abl8912
Contact Info: Robert Seder: [email protected]; Barney Graham: [email protected]
URL: https://www.science.org/doi/10.1126/science.abl8912?url_ver=Z39.88-2003&rfr_id=…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID; Emory University; BIOQUAL, Inc.; Moderna, Inc.; Johns Hopkins University
Keywords: SARS-CoV-2, virus genomic variants, boost, immune response, primates
Summary of Study: Homologous mRNA-1273 boost can significantly improve both the breadth and potency of neutralizing antibody responses and confer protection against upper and lower airway infection to a heterologous challenge virus, which is relatively resistant to in vitro neutralization.
References: PMID: 34672695 / doi: 10.1126/science.abl8912
Contact Info: Robert Seder: [email protected]; Barney Graham: [email protected]
URL: https://www.science.org/doi/10.1126/science.abl8912?url_ver=Z39.88-2003&rfr_id=…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIH, University of Oxford, NIAID, Icahn School of Medicine at Mount Sinai
Keywords: SARS-CoV-2, adenovirus-based vaccine, intranasal administration, hamsters, primates
Summary of Study: Intranasal vaccination with ChAdOx1 nCoV-19/AZD1222 reduced virus concentrations in nasal swabs in two different SARS-CoV-2 animal models, warranting further investigation as a potential vaccination route for COVID-19 vaccines.
References: PMID: 34315826 / doi: 10.1126/scitranslmed.abh0755
Contact Info: Vincent Munster: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abh0755?url_ver=Z39.88-2003&rf…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIH, University of Oxford, NIAID, Icahn School of Medicine at Mount Sinai
Keywords: SARS-CoV-2, adenovirus-based vaccine, intranasal administration, hamsters, primates
Summary of Study: Intranasal vaccination with ChAdOx1 nCoV-19/AZD1222 reduced virus concentrations in nasal swabs in two different SARS-CoV-2 animal models, warranting further investigation as a potential vaccination route for COVID-19 vaccines.
References: PMID: 34315826 / doi: 10.1126/scitranslmed.abh0755
Contact Info: Vincent Munster: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abh0755?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Johns Hopkins School of Medicine; Yale University School of Medicine
Keywords: SARS-CoV-2, several animal species, immunological response, primates
Summary of Study: This review discusses small and large animal model studies previously used in SARS-CoV-2 research that may be useful in elucidating the immunological contributions to hallmark syndromes observed with COVID-19.
References: PMID: 33914873 / doi: 10.1093/ilar/ilab010
Contact Info: Rebecca Veenhuis: [email protected]
URL: https://academic.oup.com/ilarjournal/advance-article/doi/10.1093/ilar/ilab010/6…
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Johns Hopkins School of Medicine; Yale University School of Medicine
Keywords: SARS-CoV-2, several animal species, immunological response, primates
Summary of Study: This review discusses small and large animal model studies previously used in SARS-CoV-2 research that may be useful in elucidating the immunological contributions to hallmark syndromes observed with COVID-19.
References: PMID: 33914873 / doi: 10.1093/ilar/ilab010
Contact Info: Rebecca Veenhuis: [email protected]
URL: https://academic.oup.com/ilarjournal/advance-article/doi/10.1093/ilar/ilab010/6…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Universite de Paris, Institut Pasteur and others
Keywords: SARS-CoV-2, mathematical model, viral dynamics, immune response, viral clearance, primates
Summary of Study: Results provide estimates of SARS-CoV-2 viral kinetic parameters in an experimental model of mild infection and they provide means to assess the efficacy of future antiviral treatments.
References: PMID: 33730053 / doi: 10.1371/journal.pcbi.1008785
Contact Info: Antonio Goncalves: [email protected]
URL: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008785
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Universite de Paris, Institut Pasteur and others
Keywords: SARS-CoV-2, mathematical model, viral dynamics, immune response, viral clearance, primates
Summary of Study: Results provide estimates of SARS-CoV-2 viral kinetic parameters in an experimental model of mild infection and they provide means to assess the efficacy of future antiviral treatments.
References: PMID: 33730053 / doi: 10.1371/journal.pcbi.1008785
Contact Info: Antonio Goncalves: [email protected]
URL: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008785
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, marmosets
Year Published: 2021
Study Type/Review:
NPRC/Institute: Southwest NPRC
Keywords: SARS-CoV-2, young and old animals, Acute respiratory distress, primates
Summary of Study: Acute respiratory distress in macaques and baboons recapitulates the progression of COVID-19 in humans, making them suitable as models to test vaccines and therapies.
References: PMID: 33340034/doi: 10.1038/s41564-020-00841-4
Contact Info: Deepak Kaushal: [email protected]
URL: https://www.nature.com/articles/s41564-020-00841-4
NHP Species: rhesus macaques, marmosets
Year Published: 2021
Study Type/Review:
NPRC/Institute: Southwest NPRC
Keywords: SARS-CoV-2, young and old animals, Acute respiratory distress, primates
Summary of Study: Acute respiratory distress in macaques and baboons recapitulates the progression of COVID-19 in humans, making them suitable as models to test vaccines and therapies.
References: PMID: 33340034/doi: 10.1038/s41564-020-00841-4
Contact Info: Deepak Kaushal: [email protected]
URL: https://www.nature.com/articles/s41564-020-00841-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Tulane National primate Research Center; Tulane School of Medicine; Duke University Medical Center
Keywords: SARS-CoV-2, anti-SARS-CoV-2 monoclonal antibodies, pharmacokinetics, immune response, primates
Summary of Study: A combination of two high-affinity anti-SARS-CoV-2 monoclonal antibodies (mAbs; C144-LS and C135-LS) effectively blocks development of COVID-19 in the rhesus disease model and accelerates the prospect of clinical studies with this effective antibody combination.
References: PMID: 34869063 / doi: 10.3389/fcimb.2021.753444
Contact Info: Chad Roy: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637877/
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Tulane National primate Research Center; Tulane School of Medicine; Duke University Medical Center
Keywords: SARS-CoV-2, anti-SARS-CoV-2 monoclonal antibodies, pharmacokinetics, immune response, primates
Summary of Study: A combination of two high-affinity anti-SARS-CoV-2 monoclonal antibodies (mAbs; C144-LS and C135-LS) effectively blocks development of COVID-19 in the rhesus disease model and accelerates the prospect of clinical studies with this effective antibody combination.
References: PMID: 34869063 / doi: 10.3389/fcimb.2021.753444
Contact Info: Chad Roy: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637877/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of California-Davis; California National Primate Research Center, UC Davis; Chan Zuckerberg Biohub; Vitalant Research Institute; University of Wisconsin-Madison; Wisconsin National Primate Research Center/UW Madison; University of California-San Francisco
Keywords: SARS-CoV-2, convalescent plasma, viral shedding, treatment efficiency, primates
Summary of Study: Passive immunization with convalescent plasma (CP), even during early infection, provided no significant benefit in a nonhuman primate model of SARS-CoV-2 infection.
References: PMID: 34817208 / doi: 10.1128/Spectrum.01397-21
Contact Info: Jesse Deere: [email protected]
URL: https://journals.asm.org/doi/10.1128/Spectrum.01397-21
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of California-Davis; California National Primate Research Center, UC Davis; Chan Zuckerberg Biohub; Vitalant Research Institute; University of Wisconsin-Madison; Wisconsin National Primate Research Center/UW Madison; University of California-San Francisco
Keywords: SARS-CoV-2, convalescent plasma, viral shedding, treatment efficiency, primates
Summary of Study: Passive immunization with convalescent plasma (CP), even during early infection, provided no significant benefit in a nonhuman primate model of SARS-CoV-2 infection.
References: PMID: 34817208 / doi: 10.1128/Spectrum.01397-21
Contact Info: Jesse Deere: [email protected]
URL: https://journals.asm.org/doi/10.1128/Spectrum.01397-21
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Qassim University, Buraydah, Saudi Aribia; Imam Abdulrahman Bin Faisal University, MGM Dental College and Hospital, Baba Farid University of Health Sciences, Himachal Institute of Dental Sciences, Panineeya Mahavidyalaya
Keywords: SARS-CoV-2, immune response, animal models, meta analysis, mice, hamsters, ferrets, cats, dogs, primates
Summary of Study: This systematic review found that animal models only mimic limited signs and symptoms experienced in COVID infection as compared to infections in humans, yet are still essential to understand the pathogenesis, transmissibility or viral particles, and vaccine testing.
References: PMID: 34447038 / doi: 10.4103/jpbs.JPBS_749_20
Contact Info: Muhamood Moothedath: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375911/
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Qassim University, Buraydah, Saudi Aribia; Imam Abdulrahman Bin Faisal University, MGM Dental College and Hospital, Baba Farid University of Health Sciences, Himachal Institute of Dental Sciences, Panineeya Mahavidyalaya
Keywords: SARS-CoV-2, immune response, animal models, meta analysis, mice, hamsters, ferrets, cats, dogs, primates
Summary of Study: This systematic review found that animal models only mimic limited signs and symptoms experienced in COVID infection as compared to infections in humans, yet are still essential to understand the pathogenesis, transmissibility or viral particles, and vaccine testing.
References: PMID: 34447038 / doi: 10.4103/jpbs.JPBS_749_20
Contact Info: Muhamood Moothedath: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375911/
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Brigham and Women's Hospital and Harvard Medical School, The Affiliated Hospital of Youjiang Medical Univ. for Nationalities (China), and the University of Alabama
Keywords: SARS-CoV-2, ACE2 protein expression, lung injury, mice and primates
Summary of Study: Data from this study unequivocally support the key role of ACE2 in the sinonasal mucosa as a functional reARS-CoV-2; however, the restricted baseline expression pattern of ACE1 in the lung presents a conundrum as it raises questions about alternative viral receptors or additional mechanisms of lung injury in COVID-19 pneumonia.
References: PMID: 33626084 / doi: 10.1371/journal.pone.0247510
Contact Info: Sule Cataltepe: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0247510
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Brigham and Women's Hospital and Harvard Medical School, The Affiliated Hospital of Youjiang Medical Univ. for Nationalities (China), and the University of Alabama
Keywords: SARS-CoV-2, ACE2 protein expression, lung injury, mice and primates
Summary of Study: Data from this study unequivocally support the key role of ACE2 in the sinonasal mucosa as a functional reARS-CoV-2; however, the restricted baseline expression pattern of ACE1 in the lung presents a conundrum as it raises questions about alternative viral receptors or additional mechanisms of lung injury in COVID-19 pneumonia.
References: PMID: 33626084 / doi: 10.1371/journal.pone.0247510
Contact Info: Sule Cataltepe: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0247510
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Tsinghua University School of Medicine; Chinese Academy of Sciences; Peking Union Medical College, The University of Hong Kong, and more
Keywords: SARS-CoV-2, adenovirus vector, vaccine candidate, immune response, hamsters, mice, primates
Summary of Study: ADC68, a rare chimpanzee adenovirus serotype, was used as a vector for vaccine and induced potent and protective immune responses against SARS-CoV-2 in experimental animals, providing scientific rationale for further developing ADC68-19S as a clinical vaccine against SARS-CoV-2 infection in humans.
References: PMID: 34262569 / doi: 10.3389/fimmu.2021.697074
Contact Info: Zhiwei Chen: [email protected]; Xioxhong Peng: [email protected]; Dongming Zhou: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.697074/full
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Tsinghua University School of Medicine; Chinese Academy of Sciences; Peking Union Medical College, The University of Hong Kong, and more
Keywords: SARS-CoV-2, adenovirus vector, vaccine candidate, immune response, hamsters, mice, primates
Summary of Study: ADC68, a rare chimpanzee adenovirus serotype, was used as a vector for vaccine and induced potent and protective immune responses against SARS-CoV-2 in experimental animals, providing scientific rationale for further developing ADC68-19S as a clinical vaccine against SARS-CoV-2 infection in humans.
References: PMID: 34262569 / doi: 10.3389/fimmu.2021.697074
Contact Info: Zhiwei Chen: [email protected]; Xioxhong Peng: [email protected]; Dongming Zhou: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.697074/full
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chulalongkorn University, Mahidol University, Baiya Phytopharm Co., National Center for Genetic Engineering and Biotechnology
Keywords: SARS-CoV-2, plant-produced receptor-binding domain, immune response, primates
Summary of Study: The plant-based protein RBD-Fc was shown to be immunogenic and significantly boosted a humoral and cell-mediated immune response in both mice and cynomolgus macaques. This protein has the potential for use as a vaccine candidate against SARS-CoV-2.
References: PMID: 34054909 / doi: 10.3389/fpls.2021.682953
Contact Info: Waranyoo Phoolcharoen: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158422/
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chulalongkorn University, Mahidol University, Baiya Phytopharm Co., National Center for Genetic Engineering and Biotechnology
Keywords: SARS-CoV-2, plant-produced receptor-binding domain, immune response, primates
Summary of Study: The plant-based protein RBD-Fc was shown to be immunogenic and significantly boosted a humoral and cell-mediated immune response in both mice and cynomolgus macaques. This protein has the potential for use as a vaccine candidate against SARS-CoV-2.
References: PMID: 34054909 / doi: 10.3389/fpls.2021.682953
Contact Info: Waranyoo Phoolcharoen: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158422/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: DSO National Laboratories, Singapore; University of Texas Medical Branch; Hummingbird Bioscience; and others
Keywords: SARS-CoV-2, neutralizing antibodies, immune response, hamsters and primates
Summary of Study: SC31, a potent SARS-CoV-2 neutralizing antibody isolated from a convalescent patient, demonstrated therapeutic efficacy in three different models.
References: PMID: 34161386 / doi: 10.1371/journal.pone.0253487
Contact Info: Brendon John Hanson: [email protected]; Trevor Brasel: [email protected]; Piers J. Ingram: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0253487
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: DSO National Laboratories, Singapore; University of Texas Medical Branch; Hummingbird Bioscience; and others
Keywords: SARS-CoV-2, neutralizing antibodies, immune response, hamsters and primates
Summary of Study: SC31, a potent SARS-CoV-2 neutralizing antibody isolated from a convalescent patient, demonstrated therapeutic efficacy in three different models.
References: PMID: 34161386 / doi: 10.1371/journal.pone.0253487
Contact Info: Brendon John Hanson: [email protected]; Trevor Brasel: [email protected]; Piers J. Ingram: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0253487
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Public Health England, Inovio Pharmaceuticals, Oxford University
Keywords: SARS-CoV-2, synthetic DNA vaccine candidate, immune response, primates
Summary of Study: The results in a stringent preclinical SARS-CoV-2 animal model provide further support for the efficacy and safety of the synthetic DNA vaccine INO-4800 as a prophylactic countermeasure against COVID-19.
References: PMID: 34253420 / doi: 10.1016/j.vaccine.2021.06.057
Contact Info: Kate Broderick (Inovio Pharmaceuticals, Inc.; Miles Carroll (Public Health England)
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21008070?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Public Health England, Inovio Pharmaceuticals, Oxford University
Keywords: SARS-CoV-2, synthetic DNA vaccine candidate, immune response, primates
Summary of Study: The results in a stringent preclinical SARS-CoV-2 animal model provide further support for the efficacy and safety of the synthetic DNA vaccine INO-4800 as a prophylactic countermeasure against COVID-19.
References: PMID: 34253420 / doi: 10.1016/j.vaccine.2021.06.057
Contact Info: Kate Broderick (Inovio Pharmaceuticals, Inc.; Miles Carroll (Public Health England)
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21008070?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, neurotropism, central neural system, virus transduction, primates
Summary of Study: The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys.
References: PMID: 33895780 / doi: 10.1038/s41392-021-00591-7
Contact Info: Xiaozhong Peng: [email protected]; Shuaiyao Lu: [email protected]; Hongqi Liu: [email protected]
URL: https://www.nature.com/articles/s41392-021-00591-7
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, neurotropism, central neural system, virus transduction, primates
Summary of Study: The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys.
References: PMID: 33895780 / doi: 10.1038/s41392-021-00591-7
Contact Info: Xiaozhong Peng: [email protected]; Shuaiyao Lu: [email protected]; Hongqi Liu: [email protected]
URL: https://www.nature.com/articles/s41392-021-00591-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, resources, pathology, primates
Summary of Study: Because the SARS-CoV-2 pandemic has significantly increased the demand for rhesus macaques biomedical researchers will need to consider alternative NHP models for COVID-19 research and for other biomedical research studies. The authors suggest alternatives.
References: PMID: 33785923 / doi: 10.1038/s41684-021-00755-6
Contact Info: Michael Chang: chang,[email protected]
URL: https://www.nature.com/articles/s41684-021-00755-6
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, resources, pathology, primates
Summary of Study: Because the SARS-CoV-2 pandemic has significantly increased the demand for rhesus macaques biomedical researchers will need to consider alternative NHP models for COVID-19 research and for other biomedical research studies. The authors suggest alternatives.
References: PMID: 33785923 / doi: 10.1038/s41684-021-00755-6
Contact Info: Michael Chang: chang,[email protected]
URL: https://www.nature.com/articles/s41684-021-00755-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, pigtail macaques, african green monkeys, squirrel monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIAID
Keywords: SARS-CoV-2, pulmonary histopathologic characteristics, immunohistochemistry, species comparison, primates
Summary of Study: Histopathology does not appear to be a superior readout for interpretation of vaccine and therapeutic evaluations in the NHPs studied. The recommendation of which NHP is a superior model should be based on virology data as well as further work on genetic factors that contribute to significant disease.
References: PMID: 34963391 / doi: 10.1177/03009858211067468
Contact Info: Chad Clancy: [email protected]
URL: https://journals.sagepub.com/doi/10.1177/03009858211067468?url_ver=Z39.88-2003&…
NHP Species: rhesus macaques, pigtail macaques, african green monkeys, squirrel monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIAID
Keywords: SARS-CoV-2, pulmonary histopathologic characteristics, immunohistochemistry, species comparison, primates
Summary of Study: Histopathology does not appear to be a superior readout for interpretation of vaccine and therapeutic evaluations in the NHPs studied. The recommendation of which NHP is a superior model should be based on virology data as well as further work on genetic factors that contribute to significant disease.
References: PMID: 34963391 / doi: 10.1177/03009858211067468
Contact Info: Chad Clancy: [email protected]
URL: https://journals.sagepub.com/doi/10.1177/03009858211067468?url_ver=Z39.88-2003&…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: National Health Commission of the People's Republic of China; Chinese Academy of Sciences; Nanjing Medical University; Beijing Institute of Microbiology and Epidemiology; Jiangsu Rec-biotechnology Col Ltd.
Keywords: SARS-CoV-2, neutralizing antibodies, immunization, spike protein, immunogenicity, rabbits, primates
Summary of Study: The immunogenic data derived from immunization with a combination of SARS-CoV-2 RBD and NTD demonstrate the feasibility of eliciting robust targeted immune profiles by using antibody-guided vaccine design.
References: PMID: 34676098 / doi: 10.1093/nsr/nwab053
Contact Info: Xiangxi Wang: [email protected]; Cheng-Feng Qin: [email protected]; Feng-Cai Zhu: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083607/
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: National Health Commission of the People's Republic of China; Chinese Academy of Sciences; Nanjing Medical University; Beijing Institute of Microbiology and Epidemiology; Jiangsu Rec-biotechnology Col Ltd.
Keywords: SARS-CoV-2, neutralizing antibodies, immunization, spike protein, immunogenicity, rabbits, primates
Summary of Study: The immunogenic data derived from immunization with a combination of SARS-CoV-2 RBD and NTD demonstrate the feasibility of eliciting robust targeted immune profiles by using antibody-guided vaccine design.
References: PMID: 34676098 / doi: 10.1093/nsr/nwab053
Contact Info: Xiangxi Wang: [email protected]; Cheng-Feng Qin: [email protected]; Feng-Cai Zhu: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083607/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Duke University; UNC Chapel Hill; 3M Corporate Research Materials Laboratory; Infectious Disease Research Institute; California National Primate Research Center; and others
Keywords: SARS-CoV-2, mRNA vaccine, infants, immune response, primates
Summary of Study: Infant rhesus macaques were vaccinated with an mRNA-based SARS-CoV-2 vaccine, similar to the Moderna vaccine, or an S protein plus TLR7/8 agonist-based vaccine. Both vaccines induced profound induction of neutralizing antibody titers, memory B cells responses, and SARS-CV-2 specific CD4+ T cell responses that were long-lasting, all while limiting vaccine related toxicity.
References: PMID: 34131024 / doi: 10.1126/sciimmunol.abj3684
Contact Info: Kristina De Paris: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.abj3684?url_ver=Z39.88-2003&rfr_…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Duke University; UNC Chapel Hill; 3M Corporate Research Materials Laboratory; Infectious Disease Research Institute; California National Primate Research Center; and others
Keywords: SARS-CoV-2, mRNA vaccine, infants, immune response, primates
Summary of Study: Infant rhesus macaques were vaccinated with an mRNA-based SARS-CoV-2 vaccine, similar to the Moderna vaccine, or an S protein plus TLR7/8 agonist-based vaccine. Both vaccines induced profound induction of neutralizing antibody titers, memory B cells responses, and SARS-CV-2 specific CD4+ T cell responses that were long-lasting, all while limiting vaccine related toxicity.
References: PMID: 34131024 / doi: 10.1126/sciimmunol.abj3684
Contact Info: Kristina De Paris: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.abj3684?url_ver=Z39.88-2003&rfr_…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Center for Disease Control and Prevention; Chinese Academy of Medical Sciences & Peking Union Medical College; Chinese Academy of Sciences
Keywords: SARS-CoV-2, mRNA vaccine, nanoparticles, immune response, pathology, mice and primates
Summary of Study: Using both mouse and rhesus macaque SARS-CoV-2 challenge models, this study demonstrates strong immunogenicity, protective ability and high safety profiles of SW0123 (an LPP-based mRA vaccine), and supports this promising candidate for future clinical evaluation.
References: PMID: 34059617 / doi: 10.1038/s41392-021-00634-z
Contact Info: Wenjie Tan: [email protected]; Xiaozhong Peng: [email protected]
URL: https://www.nature.com/articles/s41392-021-00634-z
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Center for Disease Control and Prevention; Chinese Academy of Medical Sciences & Peking Union Medical College; Chinese Academy of Sciences
Keywords: SARS-CoV-2, mRNA vaccine, nanoparticles, immune response, pathology, mice and primates
Summary of Study: Using both mouse and rhesus macaque SARS-CoV-2 challenge models, this study demonstrates strong immunogenicity, protective ability and high safety profiles of SW0123 (an LPP-based mRA vaccine), and supports this promising candidate for future clinical evaluation.
References: PMID: 34059617 / doi: 10.1038/s41392-021-00634-z
Contact Info: Wenjie Tan: [email protected]; Xiaozhong Peng: [email protected]
URL: https://www.nature.com/articles/s41392-021-00634-z
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: UC Davis, National Institutes of Health (Pakistan), California National Primate Research Center, New York State Department of Health
Keywords: SARS-CoV-2, multiplex test, immune response, primates
Summary of Study: The authors report the development and validation of a multiplex bead assay to simultaneously and specifically detect antibodies to the SARS-CoV-2, SARS-CoV, MERS-CoV and common human coronavirus strains (229E, NL63, OC43, HKU1). Multiplex serological assays enabled the investigation of the dynamics of immune responses in COVID-19 patients.
References: PMID: 34242356 / doi: 10.1371/journal.pone.0254367
Contact Info: Imran Khan: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0254367
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: UC Davis, National Institutes of Health (Pakistan), California National Primate Research Center, New York State Department of Health
Keywords: SARS-CoV-2, multiplex test, immune response, primates
Summary of Study: The authors report the development and validation of a multiplex bead assay to simultaneously and specifically detect antibodies to the SARS-CoV-2, SARS-CoV, MERS-CoV and common human coronavirus strains (229E, NL63, OC43, HKU1). Multiplex serological assays enabled the investigation of the dynamics of immune responses in COVID-19 patients.
References: PMID: 34242356 / doi: 10.1371/journal.pone.0254367
Contact Info: Imran Khan: [email protected]
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0254367
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences, Hynnan Key Laboratory of Vaccine Research, University of Massachusetts Medical School
Keywords: SARS-CoV-2, T cells, immune response, primates
Summary of Study: Six peptides were defined as the most frequently recognized T cell epitopes, and overlapped to produce three main long epitopes. This finding may provide a convenient pattern in the detection of T cell responses for the development of new vaccines and provides a novel target in the diagnosis of patients with COVID-19.
References: PMID: 33980582 / doi: 10.4049/jimmunol.2000922
Contact Info: Wei Cun: [email protected]
URL: https://www.jimmunol.org/content/206/11/2527.long
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences, Hynnan Key Laboratory of Vaccine Research, University of Massachusetts Medical School
Keywords: SARS-CoV-2, T cells, immune response, primates
Summary of Study: Six peptides were defined as the most frequently recognized T cell epitopes, and overlapped to produce three main long epitopes. This finding may provide a convenient pattern in the detection of T cell responses for the development of new vaccines and provides a novel target in the diagnosis of patients with COVID-19.
References: PMID: 33980582 / doi: 10.4049/jimmunol.2000922
Contact Info: Wei Cun: [email protected]
URL: https://www.jimmunol.org/content/206/11/2527.long
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Ottawa; Ottawa Hospital Research Institute; Institut du Cancer de Montreal; University of Calgary
Keywords: SARS-CoV-2, attenuated vaccinia virus vector, spike receptor binding domain, immune response, mice, primates
Summary of Study: Robust immune responses and protective immunity against SARS-CoV-2 variants were demonstrated after only a single dose of a temperature stable vaccine candidate (TOH-Vac1) that uses a replication-competent, attenuated vaccinia virus as a vector to express a membrane-tethered spike receptor binding domain antigen.
References: PMID: 34687845 / doi: 10.1016/j.ymthe.2021.10.008
Contact Info: John Bell: [email protected]; Carolina Ilkow: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1525001621005153?via%3Dihub=
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Ottawa; Ottawa Hospital Research Institute; Institut du Cancer de Montreal; University of Calgary
Keywords: SARS-CoV-2, attenuated vaccinia virus vector, spike receptor binding domain, immune response, mice, primates
Summary of Study: Robust immune responses and protective immunity against SARS-CoV-2 variants were demonstrated after only a single dose of a temperature stable vaccine candidate (TOH-Vac1) that uses a replication-competent, attenuated vaccinia virus as a vector to express a membrane-tethered spike receptor binding domain antigen.
References: PMID: 34687845 / doi: 10.1016/j.ymthe.2021.10.008
Contact Info: John Bell: [email protected]; Carolina Ilkow: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1525001621005153?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Shandong Boan Biotech Co., National Institutes for Food and Drug Control, Shuimu Biosciences, and others
Keywords: SARS-CoV-2, neutralizing antibodies, structural analysis, primates
Summary of Study: CA521^FALA is a promising antibody that reacts with SARS-CoV-2 Spike protein to strongly neutralize its activity.
References: PMID: 33893388 / doi: 10.1038/s42003-021-02029-w
Contact Info: Lan Wang: [email protected]; Yong-Qiang Deng: [email protected]; Changlin Dou: [email protected]
URL: https://www.nature.com/articles/s42003-021-02029-w
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Shandong Boan Biotech Co., National Institutes for Food and Drug Control, Shuimu Biosciences, and others
Keywords: SARS-CoV-2, neutralizing antibodies, structural analysis, primates
Summary of Study: CA521^FALA is a promising antibody that reacts with SARS-CoV-2 Spike protein to strongly neutralize its activity.
References: PMID: 33893388 / doi: 10.1038/s42003-021-02029-w
Contact Info: Lan Wang: [email protected]; Yong-Qiang Deng: [email protected]; Changlin Dou: [email protected]
URL: https://www.nature.com/articles/s42003-021-02029-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences; Tsinghua University; Advaccine Biopharmaceuticals (Suzhou)
Keywords: SARS-CoV-2, B cells, Toll-like receptor, preclinical study, virus-like particle, pathogen-like antigen, primates
Summary of Study: A PLA-based COVID-19 vaccine candidate could potentially serve as an alternative option for coping with the SARS-CoV-2 pandemic.
References: PMID: 34723223 / doi: 10.1016/j.xcrm.2021.100448
Contact Info: Zhaolin Hua: [email protected]; Hongyu Deng: [email protected]; Baidong Hou: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379121003165?via%3Dihub=
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences; Tsinghua University; Advaccine Biopharmaceuticals (Suzhou)
Keywords: SARS-CoV-2, B cells, Toll-like receptor, preclinical study, virus-like particle, pathogen-like antigen, primates
Summary of Study: A PLA-based COVID-19 vaccine candidate could potentially serve as an alternative option for coping with the SARS-CoV-2 pandemic.
References: PMID: 34723223 / doi: 10.1016/j.xcrm.2021.100448
Contact Info: Zhaolin Hua: [email protected]; Hongyu Deng: [email protected]; Baidong Hou: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379121003165?via%3Dihub=
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: ImmunityBio, Inc.; IosBio; Battelle Biomedical Research Center; NantKwest, Inc.
Keywords: SARS-CoV-2, dual-antigen vaccine, adenovirus vector, immune response, virus replication, primates
Summary of Study: In the rhesus macaque model, SC prime vaccination with two oral boosts with the dual-antigen hAd5 S-Fusion + N-ETSD vaccine provides protection from SARS-CoV-2 infection for both nasal and lung airways.
References: PMID: 34603305 / doi: 10.3389/fimmu.2021.729837
Contact Info: Patrick Soon-Shiong: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.729837/full
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: ImmunityBio, Inc.; IosBio; Battelle Biomedical Research Center; NantKwest, Inc.
Keywords: SARS-CoV-2, dual-antigen vaccine, adenovirus vector, immune response, virus replication, primates
Summary of Study: In the rhesus macaque model, SC prime vaccination with two oral boosts with the dual-antigen hAd5 S-Fusion + N-ETSD vaccine provides protection from SARS-CoV-2 infection for both nasal and lung airways.
References: PMID: 34603305 / doi: 10.3389/fimmu.2021.729837
Contact Info: Patrick Soon-Shiong: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.729837/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Oxford, Public Health England, The Pirbright Institute
Keywords: SARS-CoV-2, vaccine, immune response, pathology, primates
Summary of Study: Lung pathology caused by SARS-CoV-2 mediated pneumonia is reduced in rhesus macaques by prior vaccination with ChAdOx1 nCoV-19, which induced neutralising antibody responses after a single intramuscular administration.
References: PMID: 34312487 / doi: 10.1038/s42003-021-02443-0
Contact Info: Sarah Gilbert: [email protected]
URL: https://www.nature.com/articles/s42003-021-02443-0
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Oxford, Public Health England, The Pirbright Institute
Keywords: SARS-CoV-2, vaccine, immune response, pathology, primates
Summary of Study: Lung pathology caused by SARS-CoV-2 mediated pneumonia is reduced in rhesus macaques by prior vaccination with ChAdOx1 nCoV-19, which induced neutralising antibody responses after a single intramuscular administration.
References: PMID: 34312487 / doi: 10.1038/s42003-021-02443-0
Contact Info: Sarah Gilbert: [email protected]
URL: https://www.nature.com/articles/s42003-021-02443-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIAID; University of Colorado School of Medicine
Keywords: SARS-CoV-2, role of T cells in recovery, immune response, primates
Summary of Study: Results suggest that T cells are not critical for recovery from acute SARS-CoV-2 infections in the rhesus macaque model (which develop only mild COVID-19, similar to most humans), pointing toward B cell responses and antibodies as the essential mediators of protection from re-exposure.
References: PMID: 34311582 / doi: 10.1128/mBio.01503-21
Contact Info: Kim Hasenkrug: [email protected]
URL: https://journals.asm.org/doi/10.1128/mBio.01503-21
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIAID; University of Colorado School of Medicine
Keywords: SARS-CoV-2, role of T cells in recovery, immune response, primates
Summary of Study: Results suggest that T cells are not critical for recovery from acute SARS-CoV-2 infections in the rhesus macaque model (which develop only mild COVID-19, similar to most humans), pointing toward B cell responses and antibodies as the essential mediators of protection from re-exposure.
References: PMID: 34311582 / doi: 10.1128/mBio.01503-21
Contact Info: Kim Hasenkrug: [email protected]
URL: https://journals.asm.org/doi/10.1128/mBio.01503-21
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; CureVac AG
Keywords: SARS-CoV-2, mRNA vaccine candidate, humoral and cellular immune responses, primates
Summary of Study: Prime boost vaccination of rhesus macaques with 4 ug of CV07050101 elicited neither a uniform nor a robust immune response. However, vaccination using 8 ug of the same vaccine was protective in an NHP challenge study.
References: PMID: 34452509 / doi: 10.3390/v13081645
Contact Info: Vincent Munster: [email protected]
URL: https://www.mdpi.com/1999-4915/13/8/1645
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; CureVac AG
Keywords: SARS-CoV-2, mRNA vaccine candidate, humoral and cellular immune responses, primates
Summary of Study: Prime boost vaccination of rhesus macaques with 4 ug of CV07050101 elicited neither a uniform nor a robust immune response. However, vaccination using 8 ug of the same vaccine was protective in an NHP challenge study.
References: PMID: 34452509 / doi: 10.3390/v13081645
Contact Info: Vincent Munster: [email protected]
URL: https://www.mdpi.com/1999-4915/13/8/1645
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Sichuan University; Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, review of the current animal models, pathology, immune response, use for the testing therapeutics and vaccines, mice, hamsters, nonhuman primates, and ferrets
Summary of Study: A variety of animal models have been developed to demonstrate the transmission, pathogenesis, and immunology induced by SARS-CoV-2 and to evaluate the immunomodulatory and antiviral drugs and vaccines against COVID-19. None of these models can completely recapitulate the changes seen in COVID-19 patients. It may be beneficial for investigators to apply appropriate options of animal models depending on the scientific goals.
References: PMID: 34909757 / doi: 10.1002/mco2.98
Contact Info: Shuaiyao Lu: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662225/pdf/MCO2-2-548.pdf
NHP Species: african green monkeys, rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Sichuan University; Chinese Academy of Medical Sciences and Peking Union Medical College
Keywords: SARS-CoV-2, review of the current animal models, pathology, immune response, use for the testing therapeutics and vaccines, mice, hamsters, nonhuman primates, and ferrets
Summary of Study: A variety of animal models have been developed to demonstrate the transmission, pathogenesis, and immunology induced by SARS-CoV-2 and to evaluate the immunomodulatory and antiviral drugs and vaccines against COVID-19. None of these models can completely recapitulate the changes seen in COVID-19 patients. It may be beneficial for investigators to apply appropriate options of animal models depending on the scientific goals.
References: PMID: 34909757 / doi: 10.1002/mco2.98
Contact Info: Shuaiyao Lu: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662225/pdf/MCO2-2-548.pdf