Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Russian Academy of Sciences, Sechenov First Moscow State Medical University, Lomonosov Moscow State University
Keywords: SARS-CoV-2, serology, neutralizing antibodies, immunogenicity, inactivated vaccine, primates
Summary of Study: A B-propiolactone-inactivated whole virion vaccine CoviVac was developed and assessed. The vaccine produced stable and robust humoral immune response in mice, Syrian hamsters and common marmosets.
References: PMID: 34427172 / doi: 10.1080/22221751.2021.1971569
Contact Info: Liubov Kozlovskaya: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1971569
NHP Species: marmosets
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Russian Academy of Sciences, Sechenov First Moscow State Medical University, Lomonosov Moscow State University
Keywords: SARS-CoV-2, serology, neutralizing antibodies, immunogenicity, inactivated vaccine, primates
Summary of Study: A B-propiolactone-inactivated whole virion vaccine CoviVac was developed and assessed. The vaccine produced stable and robust humoral immune response in mice, Syrian hamsters and common marmosets.
References: PMID: 34427172 / doi: 10.1080/22221751.2021.1971569
Contact Info: Liubov Kozlovskaya: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1971569
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, hamadryas baboons, marmosets
Year Published: 2021
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center, Texas Biomedical Research Institute, Regeneron, and others
Keywords: SARS-CoV-2, severe acute respiratory syndrome, young and old animals, primates
Summary of Study: Acute respiratory distress in macaques and baboons recapitulates the progression of COVID-19 in humans, making them suitable as models to test vaccines and therapies.
References: PMID: 33340034 / doi: 10.1038/s41564-020-00841-4
Contact Info: Deepak Kaushal: [email protected], Luis Giavedoni: [email protected]
URL: https://www.nature.com/articles/s41564-020-00841-4#Sec9
NHP Species: rhesus macaques, hamadryas baboons, marmosets
Year Published: 2021
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center, Texas Biomedical Research Institute, Regeneron, and others
Keywords: SARS-CoV-2, severe acute respiratory syndrome, young and old animals, primates
Summary of Study: Acute respiratory distress in macaques and baboons recapitulates the progression of COVID-19 in humans, making them suitable as models to test vaccines and therapies.
References: PMID: 33340034 / doi: 10.1038/s41564-020-00841-4
Contact Info: Deepak Kaushal: [email protected], Luis Giavedoni: [email protected]
URL: https://www.nature.com/articles/s41564-020-00841-4#Sec9
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Duke University School of Medicine, UNC Chapel Hill, NIAID, Harvard Medical School, and others
Keywords: SARS-CoV-2, neutralizing antibodies, immune response, primates
Summary of Study: In vitro infection-enhancing RBC and NTD ABs controlled virus in vito and was rarely associated with enhanced lung pathology.
References: PMID: 34242577 / doi: 10.1016/j.cell.2021.06.021
Contact Info: Barton Haynes (Duke University School of Medicine); Kevin Saunders (Duke University School of Medicine)
URL: https://www.sciencedirect.com/science/article/pii/S009286742100756X?via%3Dihub
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Duke University School of Medicine, UNC Chapel Hill, NIAID, Harvard Medical School, and others
Keywords: SARS-CoV-2, neutralizing antibodies, immune response, primates
Summary of Study: In vitro infection-enhancing RBC and NTD ABs controlled virus in vito and was rarely associated with enhanced lung pathology.
References: PMID: 34242577 / doi: 10.1016/j.cell.2021.06.021
Contact Info: Barton Haynes (Duke University School of Medicine); Kevin Saunders (Duke University School of Medicine)
URL: https://www.sciencedirect.com/science/article/pii/S009286742100756X?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Sabzevar University of Medical Sciences, University of Edinburgh, Nagasaki University
Keywords: SARS-CoV-2, infective dose, several animal species, pathogenesis, primates
Summary of Study: This review focused on comparative infective dose studies for SARS-CoV-2, SARS-CoV-1, and MERS. The review suggests that the infective dose in humans is small, perhaps about 100 particles. Further work is required to understand the relationship between routes of transmission, infective dose, co-infection and outcomes.
References: PMID: 33849679 / doi: 10.1017/S0950268821000790
Contact Info: Sedighe Karimzadeh: [email protected]; Raj Bhopal: [email protected]
URL: https://www.cambridge.org/core/journals/epidemiology-and-infection/article/revi…
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Sabzevar University of Medical Sciences, University of Edinburgh, Nagasaki University
Keywords: SARS-CoV-2, infective dose, several animal species, pathogenesis, primates
Summary of Study: This review focused on comparative infective dose studies for SARS-CoV-2, SARS-CoV-1, and MERS. The review suggests that the infective dose in humans is small, perhaps about 100 particles. Further work is required to understand the relationship between routes of transmission, infective dose, co-infection and outcomes.
References: PMID: 33849679 / doi: 10.1017/S0950268821000790
Contact Info: Sedighe Karimzadeh: [email protected]; Raj Bhopal: [email protected]
URL: https://www.cambridge.org/core/journals/epidemiology-and-infection/article/revi…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Fudan University, Second Military Medical University, Peking University
Keywords: SARS-CoV-2, cell-based vaccine, neutralizing antibodies, immune response, pathology, mice, primates
Summary of Study: The data present strong evidence supporting the promise of K562-S (a novel cell-based vaccine candidate that uses human cell K562 as a cellular carrier to display Spike (S) protein on the membrane) as a new effective vaccine for the prevention of COVID-19.
References: PMID: 34304724 / doi: 10.1080/22221751.2021.1957400
Contact Info: Jianqing Xu: [email protected]; Xiaoyan Zhang: [email protected]; Chen Zhao: [email protected]; Ping Zhao: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1957400
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Fudan University, Second Military Medical University, Peking University
Keywords: SARS-CoV-2, cell-based vaccine, neutralizing antibodies, immune response, pathology, mice, primates
Summary of Study: The data present strong evidence supporting the promise of K562-S (a novel cell-based vaccine candidate that uses human cell K562 as a cellular carrier to display Spike (S) protein on the membrane) as a new effective vaccine for the prevention of COVID-19.
References: PMID: 34304724 / doi: 10.1080/22221751.2021.1957400
Contact Info: Jianqing Xu: [email protected]; Xiaoyan Zhang: [email protected]; Chen Zhao: [email protected]; Ping Zhao: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1957400
Coronavirus Investigated: SARS-CoV-2
NHP Species: olive baboons
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Novavax, University of Maryland, University of Oklahoma, and others
Keywords: SARS-CoV-2, subunit vaccine (NVX-CoV2373), mice and primates
Summary of Study: Administering a subunit vaccine (NVX-CoV2373) constructed from the full-length S-protein, with Matrix-M adjuvant in a nonhuman primate model induces B- and T-cell responses, hACE2-receptor-blocking antibodies, and SARS-CoV-2 neutralizing antibodies. These results support the clinical development of the NVX-C0V2373 vaccine for prevention of COVID-19.
References: PMID: 33446655 / doi: 10.1038/s41467-020-20653-8
Contact Info: Gale Smith: [email protected]
URL: https://www.nature.com/articles/s41467-020-20653-8
NHP Species: olive baboons
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Novavax, University of Maryland, University of Oklahoma, and others
Keywords: SARS-CoV-2, subunit vaccine (NVX-CoV2373), mice and primates
Summary of Study: Administering a subunit vaccine (NVX-CoV2373) constructed from the full-length S-protein, with Matrix-M adjuvant in a nonhuman primate model induces B- and T-cell responses, hACE2-receptor-blocking antibodies, and SARS-CoV-2 neutralizing antibodies. These results support the clinical development of the NVX-C0V2373 vaccine for prevention of COVID-19.
References: PMID: 33446655 / doi: 10.1038/s41467-020-20653-8
Contact Info: Gale Smith: [email protected]
URL: https://www.nature.com/articles/s41467-020-20653-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Indian Veterinary Research Institute and others
Keywords: SARS-CoV-2, domestic and wild animal species, public health
Summary of Study: This review analyzes the current evidence of SARS-CoV-2 natural infection in domestic and wild animal species and their possible implications on public health.
References: PMID: 33892621 / doi: 10.1080/01652176/2021.1921311
Contact Info: Khan Sharun: [email protected]; Kuldeep Dhama: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128218/pdf/TVEQ_41_1921311.pdf
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Indian Veterinary Research Institute and others
Keywords: SARS-CoV-2, domestic and wild animal species, public health
Summary of Study: This review analyzes the current evidence of SARS-CoV-2 natural infection in domestic and wild animal species and their possible implications on public health.
References: PMID: 33892621 / doi: 10.1080/01652176/2021.1921311
Contact Info: Khan Sharun: [email protected]; Kuldeep Dhama: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128218/pdf/TVEQ_41_1921311.pdf
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Texas Medical Branch
Keywords: SARS-CoV-2, convalescent sera, primates
Summary of Study: Convalescent plasma therapy in humans may be an effective strategy provided that donor sera contain high anti-SARS-CoV-2 neutralizing titers given in early states of the disease.
References: PMID: 33662255 / doi: 10.1016/j.celrep.2021.108837
Contact Info: Thomas W. Geisbert:
URL: https://www.sciencedirect.com/science/article/pii/S2211124721001510?via%3Dihub
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Texas Medical Branch
Keywords: SARS-CoV-2, convalescent sera, primates
Summary of Study: Convalescent plasma therapy in humans may be an effective strategy provided that donor sera contain high anti-SARS-CoV-2 neutralizing titers given in early states of the disease.
References: PMID: 33662255 / doi: 10.1016/j.celrep.2021.108837
Contact Info: Thomas W. Geisbert:
URL: https://www.sciencedirect.com/science/article/pii/S2211124721001510?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Washington Univ SOM, NIAID
Keywords: SARS-CoV-2, adenovirus-vectored vaccine, immunogenicity and protective efficacy, primates
Summary of Study: A single intranasal dose of ChAd-SARS-CoV-2-S induces neutralizing antibodies and T cell responses and limits or prevents infection in the upper and lower respiratory tracts after SARS-CoV-2 challenge in rhesus macaques.
References: PMID: 33754147 / doi: 10.1016/j.xcrm.2021.100230
Contact Info: Heinz Feldmann: [email protected]; Michael Diamond: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S266637912100046X?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Washington Univ SOM, NIAID
Keywords: SARS-CoV-2, adenovirus-vectored vaccine, immunogenicity and protective efficacy, primates
Summary of Study: A single intranasal dose of ChAd-SARS-CoV-2-S induces neutralizing antibodies and T cell responses and limits or prevents infection in the upper and lower respiratory tracts after SARS-CoV-2 challenge in rhesus macaques.
References: PMID: 33754147 / doi: 10.1016/j.xcrm.2021.100230
Contact Info: Heinz Feldmann: [email protected]; Michael Diamond: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S266637912100046X?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; CureVac AG
Keywords: SARS-CoV-2, mRNA-vaccine, spike protein, humoral and cellular immune responses, primates
Summary of Study: Prime-boost vaccination with 4 ug of vaccine candidate CV07050101 resulted in limited immune responses in four out of six non-human primates.
References: PMID: 34452509 / doi: 10.3390/v13081645
Contact Info: Vincent Munster: [email protected]
URL: https://www.mdpi.com/1999-4915/13/8/1645
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; CureVac AG
Keywords: SARS-CoV-2, mRNA-vaccine, spike protein, humoral and cellular immune responses, primates
Summary of Study: Prime-boost vaccination with 4 ug of vaccine candidate CV07050101 resulted in limited immune responses in four out of six non-human primates.
References: PMID: 34452509 / doi: 10.3390/v13081645
Contact Info: Vincent Munster: [email protected]
URL: https://www.mdpi.com/1999-4915/13/8/1645
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIH
Keywords: SARS-CoV-2, single-cell RNA sequencing, lung cells, primates
Summary of Study: Monocyte-derived macrophages recruited to the lungs, rather than tissue-resident alveolar macrophages, were most likely to be responsible for phagocytosis of infected cells and cellular debris early in infection, with their roles switching during clearance of infection.
References: PMID: 33431511 / doi: 10.1126/scitranslmed.abe8146
Contact Info: Emmie DeWit: [email protected]
URL: https://stm.sciencemag.org/content/13/578/eabe8146.short
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIH
Keywords: SARS-CoV-2, single-cell RNA sequencing, lung cells, primates
Summary of Study: Monocyte-derived macrophages recruited to the lungs, rather than tissue-resident alveolar macrophages, were most likely to be responsible for phagocytosis of infected cells and cellular debris early in infection, with their roles switching during clearance of infection.
References: PMID: 33431511 / doi: 10.1126/scitranslmed.abe8146
Contact Info: Emmie DeWit: [email protected]
URL: https://stm.sciencemag.org/content/13/578/eabe8146.short
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: NCR Biotech Science Cluster; Indian Institute of Technology Kharagpur; Krishi Vigyan Kendra; Inter University Centre for Biomedical Research and Super Speciality Hospital
Keywords: SARS-CoV-2, zoonotic diseases, one health approach, multiple species, primates
Summary of Study: This review examines the different natural and experimentally induced cases of human to animal SARS-CoV-2 infection (reverse zoonosis).
References: PMID: 34903944 / doi: 10.14202/vetworld.2021.2817-2826
Contact Info: R. Kumar Pramod: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654767/pdf/Vetworld-14-2817.pdf
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: NCR Biotech Science Cluster; Indian Institute of Technology Kharagpur; Krishi Vigyan Kendra; Inter University Centre for Biomedical Research and Super Speciality Hospital
Keywords: SARS-CoV-2, zoonotic diseases, one health approach, multiple species, primates
Summary of Study: This review examines the different natural and experimentally induced cases of human to animal SARS-CoV-2 infection (reverse zoonosis).
References: PMID: 34903944 / doi: 10.14202/vetworld.2021.2817-2826
Contact Info: R. Kumar Pramod: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654767/pdf/Vetworld-14-2817.pdf
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; CureVac AG; Tufts University Cummings School of Veterinary Medicine; University of North Carolina at Chapel Hill; Beth Israel Deaconess Medical Center; Bioqual; Washington University School of Medicine; Ragon Institute of MGH, MIT and Harvard
Keywords: SARS-CoV-2, mRNA vaccine, immunogenicity, protective efficacy, primates
Summary of Study: Optimization of non-coding regions can greatly improve the immunogenicity and protective efficacy of a non-modified mRNA SARS-CoV-2 vaccine in nonhuman primates.
References: PMID: 34794169 / doi: 10.1038/s41586-021-04231-6
Contact Info: Dan Barouch: [email protected]; Susanne Rauch: [email protected]
URL: https://www.nature.com/articles/s41586-021-04231-6
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; CureVac AG; Tufts University Cummings School of Veterinary Medicine; University of North Carolina at Chapel Hill; Beth Israel Deaconess Medical Center; Bioqual; Washington University School of Medicine; Ragon Institute of MGH, MIT and Harvard
Keywords: SARS-CoV-2, mRNA vaccine, immunogenicity, protective efficacy, primates
Summary of Study: Optimization of non-coding regions can greatly improve the immunogenicity and protective efficacy of a non-modified mRNA SARS-CoV-2 vaccine in nonhuman primates.
References: PMID: 34794169 / doi: 10.1038/s41586-021-04231-6
Contact Info: Dan Barouch: [email protected]; Susanne Rauch: [email protected]
URL: https://www.nature.com/articles/s41586-021-04231-6
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: National Institutes of Biomedical Innovation, Health and Nutrition, Tsukuba, Japan; Osaka University; Gunma University; The University of Tokyo; University of Wisconsin-Madison; Mie University Graduate School of Medicine
Keywords: SARS-CoV-2, pathogenicity, old animals, pathology, immune response, primates
Summary of Study: The COVID-19 cynomolgus monkey model reflects the pathophysiology of humans and would be useful for elucidating the pathophysiology and developing therapeutic agents and vaccines.
References: PMID: 34625475 / doi: 10.1073/pnas.2104847118
Contact Info: Yasuhiro Yasutomi: [email protected]
URL: https://www.pnas.org/content/118/43/e2104847118.long
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: National Institutes of Biomedical Innovation, Health and Nutrition, Tsukuba, Japan; Osaka University; Gunma University; The University of Tokyo; University of Wisconsin-Madison; Mie University Graduate School of Medicine
Keywords: SARS-CoV-2, pathogenicity, old animals, pathology, immune response, primates
Summary of Study: The COVID-19 cynomolgus monkey model reflects the pathophysiology of humans and would be useful for elucidating the pathophysiology and developing therapeutic agents and vaccines.
References: PMID: 34625475 / doi: 10.1073/pnas.2104847118
Contact Info: Yasuhiro Yasutomi: [email protected]
URL: https://www.pnas.org/content/118/43/e2104847118.long
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Janssen Vaccines & Prevention; Tufts University Cummings School of Veterinary Medicine; Bioqual; Ragon Institute of MGH, MIT, and Harvard.
Keywords: SARS-CoV-2, adenovirus vectored COVID-19 vaccine, virus transduction, primates
Summary of Study: A single immunization with relatively low dose of Ad26.COV2.S effectively protected against SARS-CV-2 challenge in rhesus macaques, although a higher vaccine dose may be required for protection in the upper respiratory tract.
References: PMID: 34133941 / doi: 10.1016/j.cell.2021.05.040
Contact Info: Dan Barouch: [email protected]
URL: https://www.cell.com/cell/fulltext/S0092-8674(21)00693-0?_returnURL=https%3A%2F…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Janssen Vaccines & Prevention; Tufts University Cummings School of Veterinary Medicine; Bioqual; Ragon Institute of MGH, MIT, and Harvard.
Keywords: SARS-CoV-2, adenovirus vectored COVID-19 vaccine, virus transduction, primates
Summary of Study: A single immunization with relatively low dose of Ad26.COV2.S effectively protected against SARS-CV-2 challenge in rhesus macaques, although a higher vaccine dose may be required for protection in the upper respiratory tract.
References: PMID: 34133941 / doi: 10.1016/j.cell.2021.05.040
Contact Info: Dan Barouch: [email protected]
URL: https://www.cell.com/cell/fulltext/S0092-8674(21)00693-0?_returnURL=https%3A%2F…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences; Shenzhen Third People's Hospital; Guangzhou Medical University; UT Southwestern Medical Center; and others
Keywords: SARS-CoV-2, fusion protein vaccine, immune response, rodents and primates
Summary of Study: the pan-epitope modified human I-R-F (I-P-R-F) vaccine provides rapid and complete protection throughout the upper and lower respiratory tracts against a high-dose SARS-C0V-2 challenge in rhesus macaques.
References: PMID: 34267349 / doi: 10.1038/s41422-021-00531-8
Contact Info: Yang-Xin Fu: [email protected]
URL: https://www.nature.com/articles/s41422-021-00531-8
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences; Shenzhen Third People's Hospital; Guangzhou Medical University; UT Southwestern Medical Center; and others
Keywords: SARS-CoV-2, fusion protein vaccine, immune response, rodents and primates
Summary of Study: the pan-epitope modified human I-R-F (I-P-R-F) vaccine provides rapid and complete protection throughout the upper and lower respiratory tracts against a high-dose SARS-C0V-2 challenge in rhesus macaques.
References: PMID: 34267349 / doi: 10.1038/s41422-021-00531-8
Contact Info: Yang-Xin Fu: [email protected]
URL: https://www.nature.com/articles/s41422-021-00531-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Milad Daro Noor Pharmaceutical (MDNP) Co., Iran; Stem Cell Technology Research Center (STRC); Imam Hussein University
Keywords: SARS-CoV-2, inactivated vaccine candidate, immunization, immune response, mice, guinea pigs, rabbits, primates
Summary of Study: FAKHRAVAC, a purified inactivated SARS-CoV-2 virus vaccine candidate induced neutralizing antibodies in Balb/c mice, guinea pigs, rabbits, and rhesus macaques.
References: PMID: 34835202 / doi: 10.3390/vaccines9111271
Contact Info: Ahmad Karimi Rahjerdi: [email protected] or [email protected]
URL: https://www.mdpi.com/2076-393X/9/11/1271
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Milad Daro Noor Pharmaceutical (MDNP) Co., Iran; Stem Cell Technology Research Center (STRC); Imam Hussein University
Keywords: SARS-CoV-2, inactivated vaccine candidate, immunization, immune response, mice, guinea pigs, rabbits, primates
Summary of Study: FAKHRAVAC, a purified inactivated SARS-CoV-2 virus vaccine candidate induced neutralizing antibodies in Balb/c mice, guinea pigs, rabbits, and rhesus macaques.
References: PMID: 34835202 / doi: 10.3390/vaccines9111271
Contact Info: Ahmad Karimi Rahjerdi: [email protected] or [email protected]
URL: https://www.mdpi.com/2076-393X/9/11/1271
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Eli Lilly and Co., AbCellera Biologics, UNC - Chapel Hill, University of Texas Medical Branch, and others.
Keywords: SARS-CoV-2, monoclonal antibodies, immune response, primates
Summary of Study: LY-CoV555 (aka bamlanivimab), a potent anti-spike neutralizing antibody from a hospitalized, convalescent patient with COVID-19 was followed in a pharmacokinetic study in cynomolgus monkeys and in a challenge model in rhesus macaques, where it showed impressive results. Currently in clinical testing.
References: PMID: 33820835 / doi: 10.1126/scitranslmed.abf1906
Contact Info: Bryan Jones: [email protected]; Ester Falconer: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abf1906?url_ver=Z39.88-2003&rf…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Eli Lilly and Co., AbCellera Biologics, UNC - Chapel Hill, University of Texas Medical Branch, and others.
Keywords: SARS-CoV-2, monoclonal antibodies, immune response, primates
Summary of Study: LY-CoV555 (aka bamlanivimab), a potent anti-spike neutralizing antibody from a hospitalized, convalescent patient with COVID-19 was followed in a pharmacokinetic study in cynomolgus monkeys and in a challenge model in rhesus macaques, where it showed impressive results. Currently in clinical testing.
References: PMID: 33820835 / doi: 10.1126/scitranslmed.abf1906
Contact Info: Bryan Jones: [email protected]; Ester Falconer: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abf1906?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Washington Univ, SW National Primate Research Center, Texas Biomedical Research Institute
Keywords: SARS-CoV-2, transcriptional signatures, juvenile and old animals, lungs, primates
Summary of Study: Transcriptional profiles of lungs from juvenile and old macaques infected with SARS-CoV-2 were interrogated, providing fundamentally new information on the host response in young and old macaques. This model provides relevant insights necessary for further vaccine and therapeutic development for COVID-19.
References: PMID: 33674719 / doi: 10.1038/s42003-021-01829-4
Contact Info: Makedonka Mitreva: [email protected]; Deepak Kaushal: [email protected]
URL: https://www.nature.com/articles/s42003-021-01829-4
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Washington Univ, SW National Primate Research Center, Texas Biomedical Research Institute
Keywords: SARS-CoV-2, transcriptional signatures, juvenile and old animals, lungs, primates
Summary of Study: Transcriptional profiles of lungs from juvenile and old macaques infected with SARS-CoV-2 were interrogated, providing fundamentally new information on the host response in young and old macaques. This model provides relevant insights necessary for further vaccine and therapeutic development for COVID-19.
References: PMID: 33674719 / doi: 10.1038/s42003-021-01829-4
Contact Info: Makedonka Mitreva: [email protected]; Deepak Kaushal: [email protected]
URL: https://www.nature.com/articles/s42003-021-01829-4
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Hebei Agricultural University; Military Veterinary Research Institute
Keywords: SARS-CoV-2, aerosol particles, virus transduction, primates
Summary of Study: Most SARS-CoV-2 aerosol particles exhaled by the cynomolgus monkeys in this study were smaller (<4.7 um), suggesting that aerosols might be a route for SARS-CoV-2 transmission.
References: PMID: 34152969 / doi: 10.3201/eid2707.203948
Contact Info: Yuwei Gao: [email protected]
URL: https://wwwnc.cdc.gov/eid/article/27/7/20-3948_article
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Hebei Agricultural University; Military Veterinary Research Institute
Keywords: SARS-CoV-2, aerosol particles, virus transduction, primates
Summary of Study: Most SARS-CoV-2 aerosol particles exhaled by the cynomolgus monkeys in this study were smaller (<4.7 um), suggesting that aerosols might be a route for SARS-CoV-2 transmission.
References: PMID: 34152969 / doi: 10.3201/eid2707.203948
Contact Info: Yuwei Gao: [email protected]
URL: https://wwwnc.cdc.gov/eid/article/27/7/20-3948_article
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Nankai University, Chinese Academy of Sciences, and others
Keywords: SARS-CoV-2, monoclonal antibodies, structure analysis, immune response, primates
Summary of Study: The engineered antibody P4A1 (originally identified from COVID-19 convalescent patients) exhibits an optimized pharmacokinetic and safety profile, and results in complete viral clearance in a rhesus monkey model of COVID-19 following a single injection.
References: PMID: 33976198 / doi: 10.1038/s41467-021-22926-2
Contact Info: Yu Guo: [email protected]; Hongkai Zhang: [email protected]
URL: https://www.nature.com/articles/s41467-021-22926-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Nankai University, Chinese Academy of Sciences, and others
Keywords: SARS-CoV-2, monoclonal antibodies, structure analysis, immune response, primates
Summary of Study: The engineered antibody P4A1 (originally identified from COVID-19 convalescent patients) exhibits an optimized pharmacokinetic and safety profile, and results in complete viral clearance in a rhesus monkey model of COVID-19 following a single injection.
References: PMID: 33976198 / doi: 10.1038/s41467-021-22926-2
Contact Info: Yu Guo: [email protected]; Hongkai Zhang: [email protected]
URL: https://www.nature.com/articles/s41467-021-22926-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, neurotropism, central neural system, virus transduction, primates
Summary of Study: The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys.
References: PMID: 33895780 / doi: 10.1038/s41392-021-00591-7
Contact Info: Xiaozhong Peng: [email protected]; Shuaiyao Lu: [email protected]; Hongqi Liu: [email protected]
URL: https://www.nature.com/articles/s41392-021-00591-7
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, neurotropism, central neural system, virus transduction, primates
Summary of Study: The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys.
References: PMID: 33895780 / doi: 10.1038/s41392-021-00591-7
Contact Info: Xiaozhong Peng: [email protected]; Shuaiyao Lu: [email protected]; Hongqi Liu: [email protected]
URL: https://www.nature.com/articles/s41392-021-00591-7
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP, NIH
Keywords: SARS-CoV-2, the use of primates for COVID research, animal resources
Summary of Study: The SARS-CoV-2/COVID-19 pandemic has significantly increased the demand for specific-pathogen-free (SFP) NHPs for development of vaccines and therapeutics. Non-SPF animals, which are available in greater numbers and include well-characterized primate species, should be considered in lieu of limited SPF animals for appropriate research studies.
References: doi: 10.1038/s41684-021-00810-2
Contact Info: Miguel Contreras: miguel.contreras
URL: https://www.nature.com/articles/s41684-021-00810-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP, NIH
Keywords: SARS-CoV-2, the use of primates for COVID research, animal resources
Summary of Study: The SARS-CoV-2/COVID-19 pandemic has significantly increased the demand for specific-pathogen-free (SFP) NHPs for development of vaccines and therapeutics. Non-SPF animals, which are available in greater numbers and include well-characterized primate species, should be considered in lieu of limited SPF animals for appropriate research studies.
References: doi: 10.1038/s41684-021-00810-2
Contact Info: Miguel Contreras: miguel.contreras
URL: https://www.nature.com/articles/s41684-021-00810-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Florida State University; University of Texas Medical Branch; Perelman School of Medicine; Duke University Medical Center; Johns Hopkins School of Medicine
Keywords: SARS-CoV-2, respiratory viral challenge, immune response, pathology, primates
Summary of Study: Data demonstrate that SARS-CoV-2 infection of pigtail macaques recapitulates important features of COVID-19 and reveals new immune and viral dynamics and thus may serve as a useful animal model for studying pathogenesis and testing vaccines and therapeutics.
References: PMID: 34929014 / doi: 10.1371/journal.ppat.1010162
Contact Info: Nicholas Maness: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010162
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Florida State University; University of Texas Medical Branch; Perelman School of Medicine; Duke University Medical Center; Johns Hopkins School of Medicine
Keywords: SARS-CoV-2, respiratory viral challenge, immune response, pathology, primates
Summary of Study: Data demonstrate that SARS-CoV-2 infection of pigtail macaques recapitulates important features of COVID-19 and reveals new immune and viral dynamics and thus may serve as a useful animal model for studying pathogenesis and testing vaccines and therapeutics.
References: PMID: 34929014 / doi: 10.1371/journal.ppat.1010162
Contact Info: Nicholas Maness: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010162
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Washington; University of North Carolina at Chapel Hil; Fred Hutchinson Cancer Research Center; Stanford University School of Medicine; Institut Pasteur and CNRS UMR 3569; New Iberia Research Center and Department of Biology; Washington National Primate Research Center; University of Texas at Austin; GSK; Humabs Biomed SA; Bill & Melinda Gates Foundation
Keywords: SARS-CoV-2, vaccine design, spike glycoprotein, receptor-binding domain, self-assembling nanoparticle, sarbecovirus, primates
Summary of Study: This study provides proof of the principle that multivalent sarbecovirus RBD-NPs induce heterotypic protection and motivates advancing such broadly protective sarbecovirus vaccines to the clinic.
References: PMID: 34619077 / doi: 10.1016/j.cell.2021.09.015
Contact Info: Neil King: [email protected]; David Veesler: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S009286742101062X?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Washington; University of North Carolina at Chapel Hil; Fred Hutchinson Cancer Research Center; Stanford University School of Medicine; Institut Pasteur and CNRS UMR 3569; New Iberia Research Center and Department of Biology; Washington National Primate Research Center; University of Texas at Austin; GSK; Humabs Biomed SA; Bill & Melinda Gates Foundation
Keywords: SARS-CoV-2, vaccine design, spike glycoprotein, receptor-binding domain, self-assembling nanoparticle, sarbecovirus, primates
Summary of Study: This study provides proof of the principle that multivalent sarbecovirus RBD-NPs induce heterotypic protection and motivates advancing such broadly protective sarbecovirus vaccines to the clinic.
References: PMID: 34619077 / doi: 10.1016/j.cell.2021.09.015
Contact Info: Neil King: [email protected]; David Veesler: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S009286742101062X?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center, Tulane University School of Medicine, Tulane University, Brigham and Women's Hospital/Harvard Medical School, LSU Health Science Center, Julius-Maximilians-Universitat Wurzburg, and more
Keywords: SARS-CoV-2, endotheliopathy, inflammation, primates, mice
Summary of Study: In addition to pneumocytes, SARS-CoV-2 also directly infects mature vascular endothelial cells in vivo and ex vivo which may contribute to cardiovascular complications in SARS-CoV-2 infection, including multiple organ failure.
References: PMID: 34307198 / doi: 10.3389/fcimb.2021.701278
Contact Info: Xuebin Qin: [email protected]; Suleyman Ergun: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292147/
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center, Tulane University School of Medicine, Tulane University, Brigham and Women's Hospital/Harvard Medical School, LSU Health Science Center, Julius-Maximilians-Universitat Wurzburg, and more
Keywords: SARS-CoV-2, endotheliopathy, inflammation, primates, mice
Summary of Study: In addition to pneumocytes, SARS-CoV-2 also directly infects mature vascular endothelial cells in vivo and ex vivo which may contribute to cardiovascular complications in SARS-CoV-2 infection, including multiple organ failure.
References: PMID: 34307198 / doi: 10.3389/fcimb.2021.701278
Contact Info: Xuebin Qin: [email protected]; Suleyman Ergun: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292147/
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Huazhong University of Science & Technology; Chinese Academy of Sciences; Peking University; Shanghai Junshi Biosciences Co., Ltd.; and others
Keywords: SARS-CoV-2, ACE2-blocking monoclonal antibody, receptor-binding domain, pathology, primates
Summary of Study: The ACE2-blocking MAb represents a broadly promising therapeutic candidate against emergence, re-emergence, and future zoonotic transmission events from SARSr-CoVs and variants.
References: PMID: 34404805 / doi: 10.1038/s41467-021-25331-x
Contact Info: Wenjie Tan: [email protected]
URL: https://www.nature.com/articles/s41467-021-25331-x
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Huazhong University of Science & Technology; Chinese Academy of Sciences; Peking University; Shanghai Junshi Biosciences Co., Ltd.; and others
Keywords: SARS-CoV-2, ACE2-blocking monoclonal antibody, receptor-binding domain, pathology, primates
Summary of Study: The ACE2-blocking MAb represents a broadly promising therapeutic candidate against emergence, re-emergence, and future zoonotic transmission events from SARSr-CoVs and variants.
References: PMID: 34404805 / doi: 10.1038/s41467-021-25331-x
Contact Info: Wenjie Tan: [email protected]
URL: https://www.nature.com/articles/s41467-021-25331-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Ragon Institute of MGH, MIT and Harvard; UNC Chapel Hill; Tufts University; Janssen Vaccines & Prevention.
Keywords: SARS-CoV-2, adenovirus vectored COVID-19 vaccine, humoral and cellular immune responses, genome variants, primates
Summary of Study: The Ad26.COV2.S vaccine provided robust protection against both WA1/2020 and B.1.351 variants.
References: PMID: 34161961 / doi: 10.1038/s41586-021-03732-8
Contact Info: Dan Barouch: [email protected]
URL: https://www.nature.com/articles/s41586-021-03732-8
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Ragon Institute of MGH, MIT and Harvard; UNC Chapel Hill; Tufts University; Janssen Vaccines & Prevention.
Keywords: SARS-CoV-2, adenovirus vectored COVID-19 vaccine, humoral and cellular immune responses, genome variants, primates
Summary of Study: The Ad26.COV2.S vaccine provided robust protection against both WA1/2020 and B.1.351 variants.
References: PMID: 34161961 / doi: 10.1038/s41586-021-03732-8
Contact Info: Dan Barouch: [email protected]
URL: https://www.nature.com/articles/s41586-021-03732-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Erasmus Medical Center, Biomedical Primate Research Centre, Utrecht University, Friedrich-Loeffler-Institute, and others
Keywords: SARS-CoV-2, inactivated virus vaccine, immune response, pathology, mice, primates
Summary of Study: The surrogate virus-neutralization test (sVNT) detects high titers of RBD-binding antibodies and thus is potentially useful as an assay for large seroprevalence studies that aim at detecting high titers (vaccination trials or large-scale initial testing of potential animal reservoirs.)
References: PMID: 34458548 / doi: 10.1016/j.onehlt.2021.100313
Contact Info: Carmen Embregts: [email protected]; Corine GeurtsvanKessel: c. [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2352771421001038?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Erasmus Medical Center, Biomedical Primate Research Centre, Utrecht University, Friedrich-Loeffler-Institute, and others
Keywords: SARS-CoV-2, inactivated virus vaccine, immune response, pathology, mice, primates
Summary of Study: The surrogate virus-neutralization test (sVNT) detects high titers of RBD-binding antibodies and thus is potentially useful as an assay for large seroprevalence studies that aim at detecting high titers (vaccination trials or large-scale initial testing of potential animal reservoirs.)
References: PMID: 34458548 / doi: 10.1016/j.onehlt.2021.100313
Contact Info: Carmen Embregts: [email protected]; Corine GeurtsvanKessel: c. [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2352771421001038?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Russian Academy of Sciences; Sechenov First Moscow State Medical University; Lomonosov Moscow State University
Keywords: SARS-CoV-2, inactivated vaccine, long-term humoral immunogenicity, toxicity, mice, hamsters, primates
Summary of Study: A beta-propiolactone-inactivated whole virion vaccine (CoviVac) was asses and showed no signs of acute/chronic, reproductive, embryo- and fetotoxicity or teratogenic effects, as well as no allergenic properties in the animal species studied.
References: PMID: 34427172 / doi: 10.1080/22221751.2021.1971569
Contact Info: Liubov Kozlovskaya: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1971569
NHP Species: marmosets
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Russian Academy of Sciences; Sechenov First Moscow State Medical University; Lomonosov Moscow State University
Keywords: SARS-CoV-2, inactivated vaccine, long-term humoral immunogenicity, toxicity, mice, hamsters, primates
Summary of Study: A beta-propiolactone-inactivated whole virion vaccine (CoviVac) was asses and showed no signs of acute/chronic, reproductive, embryo- and fetotoxicity or teratogenic effects, as well as no allergenic properties in the animal species studied.
References: PMID: 34427172 / doi: 10.1080/22221751.2021.1971569
Contact Info: Liubov Kozlovskaya: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1971569
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: North Carolina State University; UNC-Chapel Hill; BreStem Therapeutics, Bioqual, Inc.
Keywords: SARS-CoV-2, ACE2 nanodecoys, inhalation therapy, mice and primates
Summary of Study: ACE2 nanodecoys derived from human lung spheroid cells (LSCs) can bind and neutralize SARS-CoV-2. In cynomolgus macaques challenged with live SARS-CoV-2, four doses of these nanodecoys delivered by inhalation promoted viral clearance and reduced lung injury. these results suggest that LSC-nanodecoys can serve as a potential therapeutic agent for treating COVID-19.
References: PMID: 34140674 / doi: 10.1038/s41565-021-00923-2
Contact Info: Ke Cheng: [email protected]
URL: https://www.nature.com/articles/s41565-021-00923-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: North Carolina State University; UNC-Chapel Hill; BreStem Therapeutics, Bioqual, Inc.
Keywords: SARS-CoV-2, ACE2 nanodecoys, inhalation therapy, mice and primates
Summary of Study: ACE2 nanodecoys derived from human lung spheroid cells (LSCs) can bind and neutralize SARS-CoV-2. In cynomolgus macaques challenged with live SARS-CoV-2, four doses of these nanodecoys delivered by inhalation promoted viral clearance and reduced lung injury. these results suggest that LSC-nanodecoys can serve as a potential therapeutic agent for treating COVID-19.
References: PMID: 34140674 / doi: 10.1038/s41565-021-00923-2
Contact Info: Ke Cheng: [email protected]
URL: https://www.nature.com/articles/s41565-021-00923-2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; Emory University; Duke University Medical Center; Moderna; BIOQUAL
Keywords: SARS-CoV-2, mRNA-vaccine, immune response, hamsters, primates
Summary of Study: mRNA-1273 vaccine-induced antibody responses are a mechanistic correlate of protection against SARS-CoV-2 infection in NHP.
References: PMID: 34529476 / doi: 10.1126/science.abj0299
Contact Info: Barney Graham: [email protected]; Robert Seder: [email protected]
URL: https://www.science.org/doi/10.1126/science.abj0299?url_ver=Z39.88-2003&rfr_id=…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; Emory University; Duke University Medical Center; Moderna; BIOQUAL
Keywords: SARS-CoV-2, mRNA-vaccine, immune response, hamsters, primates
Summary of Study: mRNA-1273 vaccine-induced antibody responses are a mechanistic correlate of protection against SARS-CoV-2 infection in NHP.
References: PMID: 34529476 / doi: 10.1126/science.abj0299
Contact Info: Barney Graham: [email protected]; Robert Seder: [email protected]
URL: https://www.science.org/doi/10.1126/science.abj0299?url_ver=Z39.88-2003&rfr_id=…
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences, Nanjing University
Keywords: SARS-CoV-2, pathology, primates
Summary of Study: SARS-CoV-2-infected northern pig-tailed macaques could be considered as a critically ill animal model in COVID-19 research.
References: PMID: 33998182 / doi: 10.24272/j.issn.2095-8137.2020.334
Contact Info: Yong-Tang Zheng: [email protected]
URL: http://www.zoores.ac.cn/article/doi/10.24272/j.issn.2095-8137.2020.334
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences, Nanjing University
Keywords: SARS-CoV-2, pathology, primates
Summary of Study: SARS-CoV-2-infected northern pig-tailed macaques could be considered as a critically ill animal model in COVID-19 research.
References: PMID: 33998182 / doi: 10.24272/j.issn.2095-8137.2020.334
Contact Info: Yong-Tang Zheng: [email protected]
URL: http://www.zoores.ac.cn/article/doi/10.24272/j.issn.2095-8137.2020.334
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Texas Medical Branch
Keywords: SARS-CoV-2, apoptosis, lung tissues, pathology, primates
Summary of Study: Significant increases in apoptotic signals in postmortem lung sections from COVID-19 patients and lungs of NHPs infected with SARS-CoV-2 on day 21 p.i.
References: PMID: 33922476 / doi: 10.3390/pathogens10050509
Contact Info: Paul Boor: [email protected]; Jason Comer: [email protected]; Bin Gong: [email protected]
URL: https://www.mdpi.com/2076-0817/10/5/509
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Texas Medical Branch
Keywords: SARS-CoV-2, apoptosis, lung tissues, pathology, primates
Summary of Study: Significant increases in apoptotic signals in postmortem lung sections from COVID-19 patients and lungs of NHPs infected with SARS-CoV-2 on day 21 p.i.
References: PMID: 33922476 / doi: 10.3390/pathogens10050509
Contact Info: Paul Boor: [email protected]; Jason Comer: [email protected]; Bin Gong: [email protected]
URL: https://www.mdpi.com/2076-0817/10/5/509
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Weill Cornell Medical College
Keywords: SARS-CoV-2, vaccines, antibody and T cell immunogenicity, review, primates
Summary of Study: This review article looks at what is known of the antibody and T cell immunogenicity of vaccines that have advanced to human clinical trials. Includes summary of press releases on the outcomes of vaccine efficacy trials.
References: PMID: 33608249 / doi: 10.1126/sciadv.abe8065
Contact Info: John P. Moore: [email protected]
URL: https://advances.sciencemag.org/content/7/12/eabe8065
NHP Species: multiple species
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Weill Cornell Medical College
Keywords: SARS-CoV-2, vaccines, antibody and T cell immunogenicity, review, primates
Summary of Study: This review article looks at what is known of the antibody and T cell immunogenicity of vaccines that have advanced to human clinical trials. Includes summary of press releases on the outcomes of vaccine efficacy trials.
References: PMID: 33608249 / doi: 10.1126/sciadv.abe8065
Contact Info: John P. Moore: [email protected]
URL: https://advances.sciencemag.org/content/7/12/eabe8065
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIH
Keywords: SARS-CoV-2, review, different primate species
Summary of Study: The authors advocate for baboons as a viable alternative to rhesus macaques in SARS-CoV-2 research.
References: PMID: 33785923 / doi:10.1038/s41684-021-00755-6
Contact Info: Michael Chang: [email protected]
URL: https://www.nature.com/articles/s41684-021-00755-6
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIH
Keywords: SARS-CoV-2, review, different primate species
Summary of Study: The authors advocate for baboons as a viable alternative to rhesus macaques in SARS-CoV-2 research.
References: PMID: 33785923 / doi:10.1038/s41684-021-00755-6
Contact Info: Michael Chang: [email protected]
URL: https://www.nature.com/articles/s41684-021-00755-6
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Shanghai Zerun Biotechnology Co., Ltd.; Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College; Shanghai Medical College, Fudan University; Wuhan University; National Institute for Food and Drug Control (NIFDC)
Keywords: SARS-CoV-2, recombinant vaccine, spike trimer, immunogenicity, mice, hamsters, primates
Summary of Study: A recombinant spike protein vaccine adjuvanted with aluminium hydroxide and CpG 7909 showed high immunogenicity and good protective efficacy in preclinical studies, supporting further clinical trials.
References: PMID: 34750014 / doi: 10.1016/j.vaccine.2021.10.066
Contact Info: Ge Liu: [email protected]; Jiangning Liu: [email protected]; Youhua Xie: [email protected]; Zhongyu Hu: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21013992?via%3Dihub
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Shanghai Zerun Biotechnology Co., Ltd.; Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College; Shanghai Medical College, Fudan University; Wuhan University; National Institute for Food and Drug Control (NIFDC)
Keywords: SARS-CoV-2, recombinant vaccine, spike trimer, immunogenicity, mice, hamsters, primates
Summary of Study: A recombinant spike protein vaccine adjuvanted with aluminium hydroxide and CpG 7909 showed high immunogenicity and good protective efficacy in preclinical studies, supporting further clinical trials.
References: PMID: 34750014 / doi: 10.1016/j.vaccine.2021.10.066
Contact Info: Ge Liu: [email protected]; Jiangning Liu: [email protected]; Youhua Xie: [email protected]; Zhongyu Hu: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0264410X21013992?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Henry M. Jackson Foundation for the Advancement of Military Medicine; Washington University; National Cancer Institute/NIH; BIOQUAL; and others
Keywords: SARS-CoV-2, nanoparticle protein vaccine, humoral and cellular immune responses, primates
Summary of Study: Findings support the continued development of SARS-CoV-2 RBD ferritin nanoparticle vaccines (RFN) for managing COVID-19 and related SARS-CoV-like virus outbreaks.
References: PMID: 34470866 / doi: 10.1073/pnas.2106433118
Contact Info: Kayvon Modjarrad: [email protected]; Diane Bolton: [email protected]
URL: https://www.pnas.org/content/118/38/e2106433118.long
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Henry M. Jackson Foundation for the Advancement of Military Medicine; Washington University; National Cancer Institute/NIH; BIOQUAL; and others
Keywords: SARS-CoV-2, nanoparticle protein vaccine, humoral and cellular immune responses, primates
Summary of Study: Findings support the continued development of SARS-CoV-2 RBD ferritin nanoparticle vaccines (RFN) for managing COVID-19 and related SARS-CoV-like virus outbreaks.
References: PMID: 34470866 / doi: 10.1073/pnas.2106433118
Contact Info: Kayvon Modjarrad: [email protected]; Diane Bolton: [email protected]
URL: https://www.pnas.org/content/118/38/e2106433118.long
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences, Kunming Institute of Zoology; Institute of Infectious Diseases, Shenzhen Bay Laboratory; School of Medicine, Tsinghua University
Keywords: SARS-CoV-2, receptor-binding domain subunit vaccine, humoral and cellular immune responses, pathology, primates
Summary of Study: A trimeric SARS-CoV-2 receptor-binding domain (RBD) subunit vaccine that stimulates the natural structure of the spike (S) trimer glycoprotein is highly immunogenic and safe, providing long-lasting, broad, and significant immunity protection in NHPs. The vaccine-induced antibodies can effectively neutralize the SARS-CoV-2 501Y.V2 variant. A booster vaccination can quickly activate the memory immune response to avoid re-infection.
References: PMID: 34179862 / doi: 10.1016/j.xinn.2021.100140
Contact Info: Limin Yang: [email protected]; Yong-tang Zheng: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214323/
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences, Kunming Institute of Zoology; Institute of Infectious Diseases, Shenzhen Bay Laboratory; School of Medicine, Tsinghua University
Keywords: SARS-CoV-2, receptor-binding domain subunit vaccine, humoral and cellular immune responses, pathology, primates
Summary of Study: A trimeric SARS-CoV-2 receptor-binding domain (RBD) subunit vaccine that stimulates the natural structure of the spike (S) trimer glycoprotein is highly immunogenic and safe, providing long-lasting, broad, and significant immunity protection in NHPs. The vaccine-induced antibodies can effectively neutralize the SARS-CoV-2 501Y.V2 variant. A booster vaccination can quickly activate the memory immune response to avoid re-infection.
References: PMID: 34179862 / doi: 10.1016/j.xinn.2021.100140
Contact Info: Limin Yang: [email protected]; Yong-tang Zheng: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214323/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre (BPRC); Eurofins-INGENASA; Erasmus University Medical Center; Utrecht University
Keywords: SARS-CoV-2, post-acute phase, immune response, tomography, virus replication, primates
Summary of Study: NHPs infected with SARS-CoV-2 were followed for up to 6 weeks and monitored for COVID-19-like disease symptoms. Data indicate widespread tissue dissemination of SARS-CoV-2 in individual monkeys and provide evidence for continuing virus replication in lungs and surrounding lymph nodes after alleged convalescence of infection.
References: PMID: 34452537 / doi: 10.3390/v13081673
Contact Info: Ernst Verschoor: [email protected]
URL: https://www.mdpi.com/1999-4915/13/8/1673
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre (BPRC); Eurofins-INGENASA; Erasmus University Medical Center; Utrecht University
Keywords: SARS-CoV-2, post-acute phase, immune response, tomography, virus replication, primates
Summary of Study: NHPs infected with SARS-CoV-2 were followed for up to 6 weeks and monitored for COVID-19-like disease symptoms. Data indicate widespread tissue dissemination of SARS-CoV-2 in individual monkeys and provide evidence for continuing virus replication in lungs and surrounding lymph nodes after alleged convalescence of infection.
References: PMID: 34452537 / doi: 10.3390/v13081673
Contact Info: Ernst Verschoor: [email protected]
URL: https://www.mdpi.com/1999-4915/13/8/1673
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Battelle National Biodefense Institute; Gryphon Scientific LLC, Censeo Insight; Applied Research Associates
Keywords: SARS-CoV-2, inhalation, infection route, virus detection, dose response, primates
Summary of Study: SARS-CoV-2 infection and subsequent disease presentation are dependent on exposure dose in a nonhuman primate model of inhalational COVID-19.
References: PMID: 34424943 / doi: 10.1371/journal.ppat.1009865
Contact Info: Paul Dabisch: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009865
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Battelle National Biodefense Institute; Gryphon Scientific LLC, Censeo Insight; Applied Research Associates
Keywords: SARS-CoV-2, inhalation, infection route, virus detection, dose response, primates
Summary of Study: SARS-CoV-2 infection and subsequent disease presentation are dependent on exposure dose in a nonhuman primate model of inhalational COVID-19.
References: PMID: 34424943 / doi: 10.1371/journal.ppat.1009865
Contact Info: Paul Dabisch: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009865
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; Harvard T.H. Chan School of Public Health; Emory University; Moderna, Bioqual
Keywords: SARS-CoV-2, RNA-vaccine, immune response, virus replication, protection, primates
Summary of Study: Data establish that a two-dose regimen of mRNA-1273 (Moderna vaccine) will be critical for providing upper and lower airway protection against major variants of concern.
References: PMID: 34417590 / doi: 10.1038/s41590-021-02021-0
Contact Info: Barney Graham: [email protected]; Robert Seder: [email protected]
URL: https://www.nature.com/articles/s41590-021-01021-0
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; Harvard T.H. Chan School of Public Health; Emory University; Moderna, Bioqual
Keywords: SARS-CoV-2, RNA-vaccine, immune response, virus replication, protection, primates
Summary of Study: Data establish that a two-dose regimen of mRNA-1273 (Moderna vaccine) will be critical for providing upper and lower airway protection against major variants of concern.
References: PMID: 34417590 / doi: 10.1038/s41590-021-02021-0
Contact Info: Barney Graham: [email protected]; Robert Seder: [email protected]
URL: https://www.nature.com/articles/s41590-021-01021-0
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: The Wistar Institute, Perelman School of Medicine, NIAID, and others
Keywords: MERS-CoV, intradermal and intramuscular delivery, synthetic DNA vaccine, primates
Summary of Study: Results illustrate that a MERS spike antigen synthetic DNA vaccine administered in a 2-dose i.d. EP regimen can have positive impact in an important NHP challenge model protecting against symptoms and pathology.
References: PMID: 33886507 / doi: 10.1172/jci.insight.146082
Contact Info: David Weiner: [email protected]
URL: https://insight.jci.org/articles/view/146082
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: The Wistar Institute, Perelman School of Medicine, NIAID, and others
Keywords: MERS-CoV, intradermal and intramuscular delivery, synthetic DNA vaccine, primates
Summary of Study: Results illustrate that a MERS spike antigen synthetic DNA vaccine administered in a 2-dose i.d. EP regimen can have positive impact in an important NHP challenge model protecting against symptoms and pathology.
References: PMID: 33886507 / doi: 10.1172/jci.insight.146082
Contact Info: David Weiner: [email protected]
URL: https://insight.jci.org/articles/view/146082
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Public Health England & Welcome Trust Centre for Human Genetics
Keywords: SARS-CoV-2, pathogenicity, comparative studies, primates
Summary of Study: SARS-CoV-2 replicates in the upper and lower respiratory tract and causes pulmonary lesions in both rhesus and cynomolgus macaques. This provides convincing evidence that both macaque species authentically represent mild to moderate forms of COVID-19 observed in the majority of the human populations and both species can e used to evaluate the safety and efficacy of interventions proposed against SARS-CoV-2. Importantly, accessing cynomolgus macaques will greatly alleviate the pressures on current rhesus stocks.
References: PMID: 33627662 / doi: 10.1038/s41467-021-21389-9
Contact Info: Miles Carroll: [email protected]
URL: https://www.nature.com/articles/s41467-021-21389-9
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Public Health England & Welcome Trust Centre for Human Genetics
Keywords: SARS-CoV-2, pathogenicity, comparative studies, primates
Summary of Study: SARS-CoV-2 replicates in the upper and lower respiratory tract and causes pulmonary lesions in both rhesus and cynomolgus macaques. This provides convincing evidence that both macaque species authentically represent mild to moderate forms of COVID-19 observed in the majority of the human populations and both species can e used to evaluate the safety and efficacy of interventions proposed against SARS-CoV-2. Importantly, accessing cynomolgus macaques will greatly alleviate the pressures on current rhesus stocks.
References: PMID: 33627662 / doi: 10.1038/s41467-021-21389-9
Contact Info: Miles Carroll: [email protected]
URL: https://www.nature.com/articles/s41467-021-21389-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Wheaten College, Cornell University
Keywords: SARS-CoV-2, virus susceptibility, animal welfare, hamsters, ferrets, primates
Summary of Study: Paper reviews virus susceptibilities in species with frequent human contact, and factors that are best predictors of virus susceptibility.
References: PMID: 34359172 / doi: 10.3390/ani11072044
Contact Info: Kathleen Morgan: [email protected]
URL: https://www.mdpi.com/2076-2615/11/7/2044
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Wheaten College, Cornell University
Keywords: SARS-CoV-2, virus susceptibility, animal welfare, hamsters, ferrets, primates
Summary of Study: Paper reviews virus susceptibilities in species with frequent human contact, and factors that are best predictors of virus susceptibility.
References: PMID: 34359172 / doi: 10.3390/ani11072044
Contact Info: Kathleen Morgan: [email protected]
URL: https://www.mdpi.com/2076-2615/11/7/2044
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Beijing DanXu Biopharmaceuticals
Keywords: SARS-CoV-2, monoclonal antibody, ELISA assay, pharmacokinetic, primates
Summary of Study: In cynomolgus monkeys, BD-604 (a fully human monoclonal antibody) possesses pharmacokinetic properties similar to natural IgGs.
References: PMID: 34215019 / doi: 10.1002/dta.3122
Contact Info: Xu Zhang: [email protected]
URL: https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/dta.3122
NHP Species:
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Beijing DanXu Biopharmaceuticals
Keywords: SARS-CoV-2, monoclonal antibody, ELISA assay, pharmacokinetic, primates
Summary of Study: In cynomolgus monkeys, BD-604 (a fully human monoclonal antibody) possesses pharmacokinetic properties similar to natural IgGs.
References: PMID: 34215019 / doi: 10.1002/dta.3122
Contact Info: Xu Zhang: [email protected]
URL: https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/dta.3122
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences
Keywords: SARS-CoV-2, combined intratracheal and intranasal inoculation, primates
Summary of Study: The severity of respiratory tract infection enhanced air transmission and induced wide and severe SARS-CoV-2 infection in the lungs, suggesting the occurrence of more severe infectiousness and lung injury in SARS-CoV-2 patients with nasal infection.
References: PMID: 33587263 / doi: 10.1007/s11427-020-1877-4
Contact Info: Yong-Tang Zheng: [email protected]
URL: https://link.springer.com/article/10.1007%2Fs11427-020-1877-4
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences
Keywords: SARS-CoV-2, combined intratracheal and intranasal inoculation, primates
Summary of Study: The severity of respiratory tract infection enhanced air transmission and induced wide and severe SARS-CoV-2 infection in the lungs, suggesting the occurrence of more severe infectiousness and lung injury in SARS-CoV-2 patients with nasal infection.
References: PMID: 33587263 / doi: 10.1007/s11427-020-1877-4
Contact Info: Yong-Tang Zheng: [email protected]
URL: https://link.springer.com/article/10.1007%2Fs11427-020-1877-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID; Emory University Vaccine Center; BIOQUAL; Moderna; Johns Hopkins University
Keywords: SARS-CoV-2, variants of concern, booster, immune response, primates
Summary of Study: An additional, delayed boost with mRNA vaccines matched to either the original vaccine strain or to the heterologous challenge strain can have a marked and sustained effect on increasing the breadth of neutralization against all VOCs tested and protection in both the lower and upper airways against the beta variant.
References: PMID: 34672695 / doi: 10.1126/science.abl8912
Contact Info: Robert Seder: [email protected]; Barney Graham: [email protected]
URL: https://www.science.org/doi/10.1126/science.abl8912?url_ver=Z39.88-2003&rfr_id=…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID; Emory University Vaccine Center; BIOQUAL; Moderna; Johns Hopkins University
Keywords: SARS-CoV-2, variants of concern, booster, immune response, primates
Summary of Study: An additional, delayed boost with mRNA vaccines matched to either the original vaccine strain or to the heterologous challenge strain can have a marked and sustained effect on increasing the breadth of neutralization against all VOCs tested and protection in both the lower and upper airways against the beta variant.
References: PMID: 34672695 / doi: 10.1126/science.abl8912
Contact Info: Robert Seder: [email protected]; Barney Graham: [email protected]
URL: https://www.science.org/doi/10.1126/science.abl8912?url_ver=Z39.88-2003&rfr_id=…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Amsterdam; INSERM, CEA; National Institute for Public Health and the Environment, RIVM; Public Health Service of Amsterdam; Tergooi Hospital; Amsterdam Neuroscience, AMC; Amsterdam Infection & Immunity, AMC; Amsterdam Infection & Immunity, VUmc; The University of Melbourne; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, cross-reactive antibodies, human coronaviruses, primates
Summary of Study: The results from this study on the presence and specificity of cross-reactive antibodies to other hCoVs after SARS-CoV-2 infection and vaccination emphasize the feasibility of broad coronavirus vaccines and may guide future vaccine designs.
References: PMID: 34812143 / doi: 10.7554/eLife.70330
Contact Info: Marit J van Gils: [email protected]
URL: https://elifesciences.org/articles/70330
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Amsterdam; INSERM, CEA; National Institute for Public Health and the Environment, RIVM; Public Health Service of Amsterdam; Tergooi Hospital; Amsterdam Neuroscience, AMC; Amsterdam Infection & Immunity, AMC; Amsterdam Infection & Immunity, VUmc; The University of Melbourne; Weill Medical College of Cornell University
Keywords: SARS-CoV-2, cross-reactive antibodies, human coronaviruses, primates
Summary of Study: The results from this study on the presence and specificity of cross-reactive antibodies to other hCoVs after SARS-CoV-2 infection and vaccination emphasize the feasibility of broad coronavirus vaccines and may guide future vaccine designs.
References: PMID: 34812143 / doi: 10.7554/eLife.70330
Contact Info: Marit J van Gils: [email protected]
URL: https://elifesciences.org/articles/70330
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences, National Institute of Food and Drug Control (Beijing, China), Yunnan Provincial Infectious Disease Hospital, Yunnan Center for Disease Control and Prevention, Kunming Third People's Hospital
Keywords: SARS-CoV-2, inactivated virus vaccine, immune response, pathology, mice, primates
Summary of Study: Inactivated SARS-CoV-2 vaccine, produced by sequential inactivation with formaldehyde followed by propiolactone, was shown to be effective against SARS-Co-V 2 challenge in rhesus macaques.
References: PMID: 34462721 / doi: 10.1016/j.omtm.2021.08.005
Contact Info: Changgui Li: [email protected]; Qihan Li: [email protected]; Longding Liu: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2329050121001315?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences, National Institute of Food and Drug Control (Beijing, China), Yunnan Provincial Infectious Disease Hospital, Yunnan Center for Disease Control and Prevention, Kunming Third People's Hospital
Keywords: SARS-CoV-2, inactivated virus vaccine, immune response, pathology, mice, primates
Summary of Study: Inactivated SARS-CoV-2 vaccine, produced by sequential inactivation with formaldehyde followed by propiolactone, was shown to be effective against SARS-Co-V 2 challenge in rhesus macaques.
References: PMID: 34462721 / doi: 10.1016/j.omtm.2021.08.005
Contact Info: Changgui Li: [email protected]; Qihan Li: [email protected]; Longding Liu: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2329050121001315?via%3Dihub