Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Perelman School of Medicine (UPenn)
Keywords: SARS-CoV-2, clinical and pathologic consequences, ACE2 decoy protein, primates
Summary of Study: The ACE2 decoy (soluble forms of angiotensin-converting enzyme 2) gene therapy approach could be effectively deployed to vulnerable populations in the COVID-19 pandemic and potentially to broader populations at the outset of future coronavirus pandemics.
References: PMID: 34265018 / doi: 10.1371/journal.ppat.1009544
Contact Info: James Wilson: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009544
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Perelman School of Medicine (UPenn)
Keywords: SARS-CoV-2, clinical and pathologic consequences, ACE2 decoy protein, primates
Summary of Study: The ACE2 decoy (soluble forms of angiotensin-converting enzyme 2) gene therapy approach could be effectively deployed to vulnerable populations in the COVID-19 pandemic and potentially to broader populations at the outset of future coronavirus pandemics.
References: PMID: 34265018 / doi: 10.1371/journal.ppat.1009544
Contact Info: James Wilson: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009544
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Washington Univ SOM, NIAID
Keywords: SARS-CoV-2, adenovirus-vectored vaccine, immunogenicity and protective efficacy, primates
Summary of Study: A single intranasal dose of ChAd-SARS-CoV-2-S induces neutralizing antibodies and T cell responses and limits or prevents infection in the upper and lower respiratory tracts after SARS-CoV-2 challenge in rhesus macaques.
References: PMID: 33754147 / doi: 10.1016/j.xcrm.2021.100230
Contact Info: Heinz Feldmann: [email protected]; Michael Diamond: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S266637912100046X?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Washington Univ SOM, NIAID
Keywords: SARS-CoV-2, adenovirus-vectored vaccine, immunogenicity and protective efficacy, primates
Summary of Study: A single intranasal dose of ChAd-SARS-CoV-2-S induces neutralizing antibodies and T cell responses and limits or prevents infection in the upper and lower respiratory tracts after SARS-CoV-2 challenge in rhesus macaques.
References: PMID: 33754147 / doi: 10.1016/j.xcrm.2021.100230
Contact Info: Heinz Feldmann: [email protected]; Michael Diamond: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S266637912100046X?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; CureVac AG
Keywords: SARS-CoV-2, mRNA-vaccine, spike protein, humoral and cellular immune responses, primates
Summary of Study: Prime-boost vaccination with 4 ug of vaccine candidate CV07050101 resulted in limited immune responses in four out of six non-human primates.
References: PMID: 34452509 / doi: 10.3390/v13081645
Contact Info: Vincent Munster: [email protected]
URL: https://www.mdpi.com/1999-4915/13/8/1645
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID/NIH; CureVac AG
Keywords: SARS-CoV-2, mRNA-vaccine, spike protein, humoral and cellular immune responses, primates
Summary of Study: Prime-boost vaccination with 4 ug of vaccine candidate CV07050101 resulted in limited immune responses in four out of six non-human primates.
References: PMID: 34452509 / doi: 10.3390/v13081645
Contact Info: Vincent Munster: [email protected]
URL: https://www.mdpi.com/1999-4915/13/8/1645
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIH
Keywords: SARS-CoV-2, single-cell RNA sequencing, lung cells, primates
Summary of Study: Monocyte-derived macrophages recruited to the lungs, rather than tissue-resident alveolar macrophages, were most likely to be responsible for phagocytosis of infected cells and cellular debris early in infection, with their roles switching during clearance of infection.
References: PMID: 33431511 / doi: 10.1126/scitranslmed.abe8146
Contact Info: Emmie DeWit: [email protected]
URL: https://stm.sciencemag.org/content/13/578/eabe8146.short
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIH
Keywords: SARS-CoV-2, single-cell RNA sequencing, lung cells, primates
Summary of Study: Monocyte-derived macrophages recruited to the lungs, rather than tissue-resident alveolar macrophages, were most likely to be responsible for phagocytosis of infected cells and cellular debris early in infection, with their roles switching during clearance of infection.
References: PMID: 33431511 / doi: 10.1126/scitranslmed.abe8146
Contact Info: Emmie DeWit: [email protected]
URL: https://stm.sciencemag.org/content/13/578/eabe8146.short
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: NCR Biotech Science Cluster; Indian Institute of Technology Kharagpur; Krishi Vigyan Kendra; Inter University Centre for Biomedical Research and Super Speciality Hospital
Keywords: SARS-CoV-2, zoonotic diseases, one health approach, multiple species, primates
Summary of Study: This review examines the different natural and experimentally induced cases of human to animal SARS-CoV-2 infection (reverse zoonosis).
References: PMID: 34903944 / doi: 10.14202/vetworld.2021.2817-2826
Contact Info: R. Kumar Pramod: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654767/pdf/Vetworld-14-2817.pdf
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: NCR Biotech Science Cluster; Indian Institute of Technology Kharagpur; Krishi Vigyan Kendra; Inter University Centre for Biomedical Research and Super Speciality Hospital
Keywords: SARS-CoV-2, zoonotic diseases, one health approach, multiple species, primates
Summary of Study: This review examines the different natural and experimentally induced cases of human to animal SARS-CoV-2 infection (reverse zoonosis).
References: PMID: 34903944 / doi: 10.14202/vetworld.2021.2817-2826
Contact Info: R. Kumar Pramod: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654767/pdf/Vetworld-14-2817.pdf
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Henry M. Jackson Foundation for the Advancement of Military Medicine; Washington University; NCI/NIH; BIOQUAL; Texas Biomedical Research Institute; Columbia University Vagelos College of Physicians and Surgeons.
Keywords: SARS-CoV-2, nanoparticle protein vaccine, humoral and cellular immune responses, virus variants, primates
Summary of Study: A ferritin nanoparticle vaccine displaying the receptor-binding domain of the SARS-CoV-2 spike protein adjuvanted with Army Liposomal Formulation QS-21 induces robust and broad antibody and T cell responses, as well as protection against viral replication and lung pathology following high-dose respiratory tract challenge with SARS-CoV-2.
References: PMID: 34470866 / doi: 10.1073/pnas.2106433118
Contact Info: Kayvon Modjarrad: [email protected]; Diane Bolton: [email protected]
URL: https://www.pnas.org/content/118/38/e2106433118.long
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Henry M. Jackson Foundation for the Advancement of Military Medicine; Washington University; NCI/NIH; BIOQUAL; Texas Biomedical Research Institute; Columbia University Vagelos College of Physicians and Surgeons.
Keywords: SARS-CoV-2, nanoparticle protein vaccine, humoral and cellular immune responses, virus variants, primates
Summary of Study: A ferritin nanoparticle vaccine displaying the receptor-binding domain of the SARS-CoV-2 spike protein adjuvanted with Army Liposomal Formulation QS-21 induces robust and broad antibody and T cell responses, as well as protection against viral replication and lung pathology following high-dose respiratory tract challenge with SARS-CoV-2.
References: PMID: 34470866 / doi: 10.1073/pnas.2106433118
Contact Info: Kayvon Modjarrad: [email protected]; Diane Bolton: [email protected]
URL: https://www.pnas.org/content/118/38/e2106433118.long
Coronavirus Investigated: SARS-CoV-2
NHP Species: macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Institute for Basic Science (IBS) (Republic of Kores), Eulji University School of Medicine, Seol National University Hospital, Jeonbuk National University Medical School, Sungkyunkwan University School of Medicine
Keywords: SARS-CoV-2, nasal ciliated cells, virus tropism, primates
Summary of Study: Nasal multiciliated epithelial cells are the main target for SARS-CoV-2 infection and replication in the upper airway during the early stages of COVID-19, implying that targeting nasal ciliated cells could be an ideal strategy to prevent SARS-CoV-2 propagation.
References: PMID: 34003804 / doi: 10.1172/JCI148517
Contact Info: Ji Hoon Ahn: [email protected]; JungMo Kim: [email protected]; Seon Pyo Hong: [email protected]; Young Tae Kim: [email protected], Chang-Seop Lee: [email protected]
URL: https://www.jci.org/articles/view/148517
NHP Species: macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Institute for Basic Science (IBS) (Republic of Kores), Eulji University School of Medicine, Seol National University Hospital, Jeonbuk National University Medical School, Sungkyunkwan University School of Medicine
Keywords: SARS-CoV-2, nasal ciliated cells, virus tropism, primates
Summary of Study: Nasal multiciliated epithelial cells are the main target for SARS-CoV-2 infection and replication in the upper airway during the early stages of COVID-19, implying that targeting nasal ciliated cells could be an ideal strategy to prevent SARS-CoV-2 propagation.
References: PMID: 34003804 / doi: 10.1172/JCI148517
Contact Info: Ji Hoon Ahn: [email protected]; JungMo Kim: [email protected]; Seon Pyo Hong: [email protected]; Young Tae Kim: [email protected], Chang-Seop Lee: [email protected]
URL: https://www.jci.org/articles/view/148517
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Universite Paris-Saclay/Inserm/CEA; Vaccine Research INstitute, Creteil, France; Inserm; Baylor Scott and White Research Institute; Institut Pasteur; Karolinska Institutet; and others
Keywords: SARS-CoV-2, subunit vaccine, receptor-binding domain, immune response, humanized mice, primates
Summary of Study: A single dose of the alphaCD40.RBD (a vaccine that targets the receptor-binding domain of the SARS-CoV-2 spike antigen to the CD40 receptor) administered without adjuvant boosts the protective response in COVID-10 convalescent NHPs.
References: PMID: 34471122 / doi: 10.1038/s41467-021-25382-0
Contact Info: Yves Levy: [email protected]
URL: https://www.nature.com/articles/s41467-021-25382-0
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Universite Paris-Saclay/Inserm/CEA; Vaccine Research INstitute, Creteil, France; Inserm; Baylor Scott and White Research Institute; Institut Pasteur; Karolinska Institutet; and others
Keywords: SARS-CoV-2, subunit vaccine, receptor-binding domain, immune response, humanized mice, primates
Summary of Study: A single dose of the alphaCD40.RBD (a vaccine that targets the receptor-binding domain of the SARS-CoV-2 spike antigen to the CD40 receptor) administered without adjuvant boosts the protective response in COVID-10 convalescent NHPs.
References: PMID: 34471122 / doi: 10.1038/s41467-021-25382-0
Contact Info: Yves Levy: [email protected]
URL: https://www.nature.com/articles/s41467-021-25382-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School, University of North Carolina at Chapel Hill, Ragon Institute of MGH, MIT, and Harvard, Massachusetts Consortium on Pathogen Readiness
Keywords: SARS-CoV-2, adenovirus vaccine, immunogenicity and protective efficacy, mice
Summary of Study: RhAd52 vaccines elicit robust SARS-CoV-2 specific antibody responses and protect against clinical disease and viral replication in the lungs. These data validate the MA10 mouse model as a useful tool to screen and study novel vaccine candidates, as well as the development of RhAd52 vaccines for COVID-19.
References: PMID: 34523968 / doi: 10.1128/JVI.00974-21
Contact Info: Dan Barouch: [email protected]
URL: https://journals.asm.org/doi/10.1128/JVI.00974-21?url_ver=Z39.88-2003&rfr_id=or…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School, University of North Carolina at Chapel Hill, Ragon Institute of MGH, MIT, and Harvard, Massachusetts Consortium on Pathogen Readiness
Keywords: SARS-CoV-2, adenovirus vaccine, immunogenicity and protective efficacy, mice
Summary of Study: RhAd52 vaccines elicit robust SARS-CoV-2 specific antibody responses and protect against clinical disease and viral replication in the lungs. These data validate the MA10 mouse model as a useful tool to screen and study novel vaccine candidates, as well as the development of RhAd52 vaccines for COVID-19.
References: PMID: 34523968 / doi: 10.1128/JVI.00974-21
Contact Info: Dan Barouch: [email protected]
URL: https://journals.asm.org/doi/10.1128/JVI.00974-21?url_ver=Z39.88-2003&rfr_id=or…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Wisconsin National Primate Research Center, Harvard Medical School, Tufts University, BIOQUAL, Ragon Institute of MGH, MIT and Harvard
Keywords: SARS-CoV-2, prior infection, vaccination, virus variants, protection, hamsters, primates
Summary of Study: Data suggest partial but reduced short-term protective efficacy of WA1/2020 natural immunity against SARS-CoV-2 variants of concern. More research is needed to define protective efficacy against other SARS-CoV-2 variants and the immunologic mechanisms of protection against these variants.
References: PMID: 34546094 / doi: 10.1126/scitranslmed.abj2641
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abj2641?url_ver=Z39.88-2003&rf…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Wisconsin National Primate Research Center, Harvard Medical School, Tufts University, BIOQUAL, Ragon Institute of MGH, MIT and Harvard
Keywords: SARS-CoV-2, prior infection, vaccination, virus variants, protection, hamsters, primates
Summary of Study: Data suggest partial but reduced short-term protective efficacy of WA1/2020 natural immunity against SARS-CoV-2 variants of concern. More research is needed to define protective efficacy against other SARS-CoV-2 variants and the immunologic mechanisms of protection against these variants.
References: PMID: 34546094 / doi: 10.1126/scitranslmed.abj2641
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abj2641?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Battelle National Biodefense Institute; Gryphon Scientific LLC; Censeo Insight; Applied Research Associates
Keywords: SARS-CoV-2, inhalation, seroconversion, fever, dose response, primates
Summary of Study: SARS-CoV-2 infection and subsequent disease presentation are dependent on exposure dose in a nonhuman primate model of inhalational COVID-19.
References: PMID: 34424943 / doi: 10.1371/journal.ppat.1009865
Contact Info: Paul Dabisch: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009865
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Battelle National Biodefense Institute; Gryphon Scientific LLC; Censeo Insight; Applied Research Associates
Keywords: SARS-CoV-2, inhalation, seroconversion, fever, dose response, primates
Summary of Study: SARS-CoV-2 infection and subsequent disease presentation are dependent on exposure dose in a nonhuman primate model of inhalational COVID-19.
References: PMID: 34424943 / doi: 10.1371/journal.ppat.1009865
Contact Info: Paul Dabisch: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009865
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: VaxiGen, Inc., Genexine, Inc., Korea National Primate Research Centre, and others
Keywords: SARS-CoV-2, DNA-based vaccine, mice and primates, immune response
Summary of Study: A synthetic soluble SARS-CoV-2 spike (S) DNA-based vaccine candidate, GX-19, provides a durable protective immune response in rhesus macaques, supporting further development of GX-19 as a vaccine candidate for SARS-CoV-2.
References: PMID: 33804981 / doi: 10.3390/vaccines9040307
Contact Info: Yong Bok Seo: [email protected]; You Suk Suh: [email protected]; Jung Joo Hong: [email protected]
URL: https://www.mdpi.com/2076-393X/9/4/307
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: VaxiGen, Inc., Genexine, Inc., Korea National Primate Research Centre, and others
Keywords: SARS-CoV-2, DNA-based vaccine, mice and primates, immune response
Summary of Study: A synthetic soluble SARS-CoV-2 spike (S) DNA-based vaccine candidate, GX-19, provides a durable protective immune response in rhesus macaques, supporting further development of GX-19 as a vaccine candidate for SARS-CoV-2.
References: PMID: 33804981 / doi: 10.3390/vaccines9040307
Contact Info: Yong Bok Seo: [email protected]; You Suk Suh: [email protected]; Jung Joo Hong: [email protected]
URL: https://www.mdpi.com/2076-393X/9/4/307
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Univ. of Pennsylvania Perelman School of Medicine
Keywords: SARS-CoV-2, D614G Spike Mutation, Vaccinated and immune sera, neutralization, primates
Summary of Study: Vaccinated NHPs using the nucleoside-modified mRNA-LNP vaccine platform encoding four differentSARS-CoV-2 spike immunogens generate antibody responses that not only recognize the G614 mutation that has taken over the pandemic, but also have stronger titers of neutralization to this virus variant.
References: PMID: 33306985/doi: 10.1016/j.chom.2020.11.012
Contact Info: Drew Weissman (no contact information)
URL: https://www.sciencedirect.com/science/article/pii/S193131282030634X?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Univ. of Pennsylvania Perelman School of Medicine
Keywords: SARS-CoV-2, D614G Spike Mutation, Vaccinated and immune sera, neutralization, primates
Summary of Study: Vaccinated NHPs using the nucleoside-modified mRNA-LNP vaccine platform encoding four differentSARS-CoV-2 spike immunogens generate antibody responses that not only recognize the G614 mutation that has taken over the pandemic, but also have stronger titers of neutralization to this virus variant.
References: PMID: 33306985/doi: 10.1016/j.chom.2020.11.012
Contact Info: Drew Weissman (no contact information)
URL: https://www.sciencedirect.com/science/article/pii/S193131282030634X?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, inactivated vaccines, antibody-dependent enhancement, immunopathology, primates
Summary of Study: Results show that in the absence of cellular immunity, passive infusion of subneutralizing or nonneutralizing anti-SARS-CoV-2 antibodies could still provide some level of protection against infection upon challenge, and no low-level antibody-enhanced infection was observed.
References: PMID: 34736354 / doi: 10.1080/22221751.2021.2002670
Contact Info: Qihan Li: [email protected]; Longding Liu: [email protected]; Cunbao Liu: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2002670
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, inactivated vaccines, antibody-dependent enhancement, immunopathology, primates
Summary of Study: Results show that in the absence of cellular immunity, passive infusion of subneutralizing or nonneutralizing anti-SARS-CoV-2 antibodies could still provide some level of protection against infection upon challenge, and no low-level antibody-enhanced infection was observed.
References: PMID: 34736354 / doi: 10.1080/22221751.2021.2002670
Contact Info: Qihan Li: [email protected]; Longding Liu: [email protected]; Cunbao Liu: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2002670
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Beijing DanXu Biopharmaceuticals
Keywords: SARS-CoV-2, monoclonal antibody, ELISA assay, pharmacokinetic, primates
Summary of Study: In cynomolgus monkeys, BD-604 (a fully human monoclonal antibody) possesses pharmacokinetic properties similar to natural IgGs.
References: PMID: 34215019 / doi: 10.1002/dta.3122
Contact Info: Xu Zhang: [email protected]
URL: https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/dta.3122
NHP Species:
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Beijing DanXu Biopharmaceuticals
Keywords: SARS-CoV-2, monoclonal antibody, ELISA assay, pharmacokinetic, primates
Summary of Study: In cynomolgus monkeys, BD-604 (a fully human monoclonal antibody) possesses pharmacokinetic properties similar to natural IgGs.
References: PMID: 34215019 / doi: 10.1002/dta.3122
Contact Info: Xu Zhang: [email protected]
URL: https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/dta.3122
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences
Keywords: SARS-CoV-2, combined intratracheal and intranasal inoculation, primates
Summary of Study: The severity of respiratory tract infection enhanced air transmission and induced wide and severe SARS-CoV-2 infection in the lungs, suggesting the occurrence of more severe infectiousness and lung injury in SARS-CoV-2 patients with nasal infection.
References: PMID: 33587263 / doi: 10.1007/s11427-020-1877-4
Contact Info: Yong-Tang Zheng: [email protected]
URL: https://link.springer.com/article/10.1007%2Fs11427-020-1877-4
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences
Keywords: SARS-CoV-2, combined intratracheal and intranasal inoculation, primates
Summary of Study: The severity of respiratory tract infection enhanced air transmission and induced wide and severe SARS-CoV-2 infection in the lungs, suggesting the occurrence of more severe infectiousness and lung injury in SARS-CoV-2 patients with nasal infection.
References: PMID: 33587263 / doi: 10.1007/s11427-020-1877-4
Contact Info: Yong-Tang Zheng: [email protected]
URL: https://link.springer.com/article/10.1007%2Fs11427-020-1877-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Florida State University; University of Texas Medical Branch; Perelman School of Medicine; Duke University Medical Center; Johns Hopkins School of Medicine
Keywords: SARS-CoV-2, respiratory viral challenge, immune response, pathology, primates
Summary of Study: Data demonstrate that SARS-CoV-2 infection of pigtail macaques recapitulates important features of COVID-19 and reveals new immune and viral dynamics and thus may serve as a useful animal model for studying pathogenesis and testing vaccines and therapeutics.
References: PMID: 34929014 / doi: 10.1371/journal.ppat.1010162
Contact Info: Nicholas Maness: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010162
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Florida State University; University of Texas Medical Branch; Perelman School of Medicine; Duke University Medical Center; Johns Hopkins School of Medicine
Keywords: SARS-CoV-2, respiratory viral challenge, immune response, pathology, primates
Summary of Study: Data demonstrate that SARS-CoV-2 infection of pigtail macaques recapitulates important features of COVID-19 and reveals new immune and viral dynamics and thus may serve as a useful animal model for studying pathogenesis and testing vaccines and therapeutics.
References: PMID: 34929014 / doi: 10.1371/journal.ppat.1010162
Contact Info: Nicholas Maness: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010162
Coronavirus Investigated: SARS-CoV-2
NHP Species: tamarins, marmosets, howler monkeys, titi monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Faculdade de Medicina de Sao Jose do Rio Preto, Brazil; Fundacao de Medicina Tropical Doutor Heitor Vieria Dourado, Brazil; Universidade do Estado do Amazonas, Brazil; Universidade Federal do Amazonas, Brazil; Universidade de Sao Paulo, Brazil; Hospital Israelita Albert Einstein; Instituto Butanta; Departamento de Vigilancia Epidemiologica de Sao Jose do Rio Preto; New Mexico State University; The University of Texas Medical Branch, Galveston; Instituto Leonidas e Maria Deane, Brazil
Keywords: SARS-CoV-2, wild animals, molecular and serological tests, primates
Summary of Study: Although no evidence of SARS-CoV-2 infection was detected, continued surveillance of NHPs in this region is warranted and may identify geographic areas or particular NHP species prone to spillover.
References: PMID: 34696363 / doi: 10.3390/v13101933
Contact Info: Marcus Vinicius Guimaraes de Lacerda: [email protected]; Mauricio Lacerda Nogueira: [email protected]
URL: https://www.mdpi.com/1999-4915/13/10/1933
NHP Species: tamarins, marmosets, howler monkeys, titi monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Faculdade de Medicina de Sao Jose do Rio Preto, Brazil; Fundacao de Medicina Tropical Doutor Heitor Vieria Dourado, Brazil; Universidade do Estado do Amazonas, Brazil; Universidade Federal do Amazonas, Brazil; Universidade de Sao Paulo, Brazil; Hospital Israelita Albert Einstein; Instituto Butanta; Departamento de Vigilancia Epidemiologica de Sao Jose do Rio Preto; New Mexico State University; The University of Texas Medical Branch, Galveston; Instituto Leonidas e Maria Deane, Brazil
Keywords: SARS-CoV-2, wild animals, molecular and serological tests, primates
Summary of Study: Although no evidence of SARS-CoV-2 infection was detected, continued surveillance of NHPs in this region is warranted and may identify geographic areas or particular NHP species prone to spillover.
References: PMID: 34696363 / doi: 10.3390/v13101933
Contact Info: Marcus Vinicius Guimaraes de Lacerda: [email protected]; Mauricio Lacerda Nogueira: [email protected]
URL: https://www.mdpi.com/1999-4915/13/10/1933
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center, Tulane University School of Medicine, Tulane University, Brigham and Women's Hospital/Harvard Medical School, LSU Health Science Center, Julius-Maximilians-Universitat Wurzburg, and more
Keywords: SARS-CoV-2, pulmonary vascular endotheliosis, perivascular inflammation, rodents and primates
Summary of Study: SARS-CoV-2 causes endotheliitis via both infection and infection-mediated immune activation, which may contribute to the pathogenesis of severe COVID-19 disease.
References: PMID: 34335981 / doi: 10.7150/thno.61810
Contact Info: Jay Kolls: [email protected]; Fengming Liu: [email protected]; Jay Rappaport: [email protected]
URL: https://www.thno.org/v11p8076.htm
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center, Tulane University School of Medicine, Tulane University, Brigham and Women's Hospital/Harvard Medical School, LSU Health Science Center, Julius-Maximilians-Universitat Wurzburg, and more
Keywords: SARS-CoV-2, pulmonary vascular endotheliosis, perivascular inflammation, rodents and primates
Summary of Study: SARS-CoV-2 causes endotheliitis via both infection and infection-mediated immune activation, which may contribute to the pathogenesis of severe COVID-19 disease.
References: PMID: 34335981 / doi: 10.7150/thno.61810
Contact Info: Jay Kolls: [email protected]; Fengming Liu: [email protected]; Jay Rappaport: [email protected]
URL: https://www.thno.org/v11p8076.htm
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences; Shenzhen Kangtai Biotechnology Co., Ltd.; Academy of Military Medical Sciences; Zhenzhou University; National Institutes for Food and Drug Control; Henan Normal University
Keywords: SARS-CoV-2, chimeric spike protein, humoral immune response, pathology, mice, primates
Summary of Study: The strategy of chimerica expression SARS-CoV-2 S RBD in SARS-CoV represents a new design for other vaccine platforms.
References: PMID: 34759261 / doi: 10.1038/s41392-021-00797-9
Contact Info: Shuguang Duo: [email protected]
URL: https://www.nature.com/articles/s41392-021-00797-9
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences; Shenzhen Kangtai Biotechnology Co., Ltd.; Academy of Military Medical Sciences; Zhenzhou University; National Institutes for Food and Drug Control; Henan Normal University
Keywords: SARS-CoV-2, chimeric spike protein, humoral immune response, pathology, mice, primates
Summary of Study: The strategy of chimerica expression SARS-CoV-2 S RBD in SARS-CoV represents a new design for other vaccine platforms.
References: PMID: 34759261 / doi: 10.1038/s41392-021-00797-9
Contact Info: Shuguang Duo: [email protected]
URL: https://www.nature.com/articles/s41392-021-00797-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Celltech Pharmed Co.; Iran University of Medical Sciences; University of Iran; Tarbiat Modares University; Royan Institute for Stem Cell Biology and Technology; and others
Keywords: SARS-CoV-2, mRNA-vaccine, lipid nanoparticle, spike protein, immune response, primates
Summary of Study: A novel mRNA-LNP vaccine against SARS-CoV-2 was developed and preclinically evaluated, revealing that it was efficient enough to induce high level production of neutralizing antibodies against SARS-CoV-2 in mice and rhesus macaque monkeys.
References: PMID: 34579244 / doi: 10.3390/vaccines9091007
Contact Info: Alireza Sohi: [email protected]; Jafar Kiani: [email protected]; Ehsan Arefian: [email protected]; Arezou Khosrojerdi: [email protected]; Mohammad Zim: [email protected]
URL: https://www.mdpi.com/2076-393X/9/9/1007
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Celltech Pharmed Co.; Iran University of Medical Sciences; University of Iran; Tarbiat Modares University; Royan Institute for Stem Cell Biology and Technology; and others
Keywords: SARS-CoV-2, mRNA-vaccine, lipid nanoparticle, spike protein, immune response, primates
Summary of Study: A novel mRNA-LNP vaccine against SARS-CoV-2 was developed and preclinically evaluated, revealing that it was efficient enough to induce high level production of neutralizing antibodies against SARS-CoV-2 in mice and rhesus macaque monkeys.
References: PMID: 34579244 / doi: 10.3390/vaccines9091007
Contact Info: Alireza Sohi: [email protected]; Jafar Kiani: [email protected]; Ehsan Arefian: [email protected]; Arezou Khosrojerdi: [email protected]; Mohammad Zim: [email protected]
URL: https://www.mdpi.com/2076-393X/9/9/1007
Coronavirus Investigated: SARS-CoV-2
NHP Species: lemurs, lorises
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Calgary; Institut de Biologia Evolutiva, Universitat Pompeu Fabra; North Carolina Central University, Duke University and others
Keywords: SARS-CoV-2, ACE2 gene and protein sequences, several species, primates
Summary of Study: Study suggests that lemurs of the families Indriidae, Daubentonlidae, and Lemuridae are likely to be particularly vulnerable to SARS-CoV-2 infection.
References: PMID: 33792947 / doi: 10.1002/ajp.23255
Contact Info: James Higham: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/ajp.23255
NHP Species: lemurs, lorises
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Calgary; Institut de Biologia Evolutiva, Universitat Pompeu Fabra; North Carolina Central University, Duke University and others
Keywords: SARS-CoV-2, ACE2 gene and protein sequences, several species, primates
Summary of Study: Study suggests that lemurs of the families Indriidae, Daubentonlidae, and Lemuridae are likely to be particularly vulnerable to SARS-CoV-2 infection.
References: PMID: 33792947 / doi: 10.1002/ajp.23255
Contact Info: James Higham: [email protected]
URL: https://onlinelibrary.wiley.com/doi/10.1002/ajp.23255
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences
Keywords: SARS-CoV-2, virus entry mediated by ACE2, several species
Summary of Study: A natural isoform of the rhesus macaque ACE2 protein with the Y217N mutation was resistant to SARS-CoV-2 infection, highlighting the possible impact of this ACE2 mutation on SARS-CoV-2 studies in rhesus macaques. The authors also demonstrated that the Y217 residue of ACE2 is a critical determinant for the ability of ACE2 to mediate SARS-CoV-2 entry. The results of this study clarify that SARS-CoV-2 can use the ACE2 receptors of multiple animal species and show that tracking the natural reservoirs and intermediate hosts of SARS-CoV-2 is complex.
References: PMID: 33610551 / doi: 10.1016/j.jbc.2021.100435
Contact Info: Yan-Dong Tang: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0021925821002088?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences
Keywords: SARS-CoV-2, virus entry mediated by ACE2, several species
Summary of Study: A natural isoform of the rhesus macaque ACE2 protein with the Y217N mutation was resistant to SARS-CoV-2 infection, highlighting the possible impact of this ACE2 mutation on SARS-CoV-2 studies in rhesus macaques. The authors also demonstrated that the Y217 residue of ACE2 is a critical determinant for the ability of ACE2 to mediate SARS-CoV-2 entry. The results of this study clarify that SARS-CoV-2 can use the ACE2 receptors of multiple animal species and show that tracking the natural reservoirs and intermediate hosts of SARS-CoV-2 is complex.
References: PMID: 33610551 / doi: 10.1016/j.jbc.2021.100435
Contact Info: Yan-Dong Tang: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0021925821002088?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Russian Academy of Sciences, Sechenov First Moscow State Medical University, Lomonosov Moscow State University
Keywords: SARS-CoV-2, serology, neutralizing antibodies, immunogenicity, inactivated vaccine, primates
Summary of Study: A B-propiolactone-inactivated whole virion vaccine CoviVac was developed and assessed. The vaccine produced stable and robust humoral immune response in mice, Syrian hamsters and common marmosets.
References: PMID: 34427172 / doi: 10.1080/22221751.2021.1971569
Contact Info: Liubov Kozlovskaya: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1971569
NHP Species: marmosets
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Russian Academy of Sciences, Sechenov First Moscow State Medical University, Lomonosov Moscow State University
Keywords: SARS-CoV-2, serology, neutralizing antibodies, immunogenicity, inactivated vaccine, primates
Summary of Study: A B-propiolactone-inactivated whole virion vaccine CoviVac was developed and assessed. The vaccine produced stable and robust humoral immune response in mice, Syrian hamsters and common marmosets.
References: PMID: 34427172 / doi: 10.1080/22221751.2021.1971569
Contact Info: Liubov Kozlovskaya: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1971569
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, hamadryas baboons, marmosets
Year Published: 2021
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center, Texas Biomedical Research Institute, Regeneron, and others
Keywords: SARS-CoV-2, severe acute respiratory syndrome, young and old animals, primates
Summary of Study: Acute respiratory distress in macaques and baboons recapitulates the progression of COVID-19 in humans, making them suitable as models to test vaccines and therapies.
References: PMID: 33340034 / doi: 10.1038/s41564-020-00841-4
Contact Info: Deepak Kaushal: [email protected], Luis Giavedoni: [email protected]
URL: https://www.nature.com/articles/s41564-020-00841-4#Sec9
NHP Species: rhesus macaques, hamadryas baboons, marmosets
Year Published: 2021
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center, Texas Biomedical Research Institute, Regeneron, and others
Keywords: SARS-CoV-2, severe acute respiratory syndrome, young and old animals, primates
Summary of Study: Acute respiratory distress in macaques and baboons recapitulates the progression of COVID-19 in humans, making them suitable as models to test vaccines and therapies.
References: PMID: 33340034 / doi: 10.1038/s41564-020-00841-4
Contact Info: Deepak Kaushal: [email protected], Luis Giavedoni: [email protected]
URL: https://www.nature.com/articles/s41564-020-00841-4#Sec9
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Duke University School of Medicine, UNC Chapel Hill, NIAID, Harvard Medical School, and others
Keywords: SARS-CoV-2, neutralizing antibodies, immune response, primates
Summary of Study: In vitro infection-enhancing RBC and NTD ABs controlled virus in vito and was rarely associated with enhanced lung pathology.
References: PMID: 34242577 / doi: 10.1016/j.cell.2021.06.021
Contact Info: Barton Haynes (Duke University School of Medicine); Kevin Saunders (Duke University School of Medicine)
URL: https://www.sciencedirect.com/science/article/pii/S009286742100756X?via%3Dihub
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Duke University School of Medicine, UNC Chapel Hill, NIAID, Harvard Medical School, and others
Keywords: SARS-CoV-2, neutralizing antibodies, immune response, primates
Summary of Study: In vitro infection-enhancing RBC and NTD ABs controlled virus in vito and was rarely associated with enhanced lung pathology.
References: PMID: 34242577 / doi: 10.1016/j.cell.2021.06.021
Contact Info: Barton Haynes (Duke University School of Medicine); Kevin Saunders (Duke University School of Medicine)
URL: https://www.sciencedirect.com/science/article/pii/S009286742100756X?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Sabzevar University of Medical Sciences, University of Edinburgh, Nagasaki University
Keywords: SARS-CoV-2, infective dose, several animal species, pathogenesis, primates
Summary of Study: This review focused on comparative infective dose studies for SARS-CoV-2, SARS-CoV-1, and MERS. The review suggests that the infective dose in humans is small, perhaps about 100 particles. Further work is required to understand the relationship between routes of transmission, infective dose, co-infection and outcomes.
References: PMID: 33849679 / doi: 10.1017/S0950268821000790
Contact Info: Sedighe Karimzadeh: [email protected]; Raj Bhopal: [email protected]
URL: https://www.cambridge.org/core/journals/epidemiology-and-infection/article/revi…
NHP Species: rhesus macaques, african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Sabzevar University of Medical Sciences, University of Edinburgh, Nagasaki University
Keywords: SARS-CoV-2, infective dose, several animal species, pathogenesis, primates
Summary of Study: This review focused on comparative infective dose studies for SARS-CoV-2, SARS-CoV-1, and MERS. The review suggests that the infective dose in humans is small, perhaps about 100 particles. Further work is required to understand the relationship between routes of transmission, infective dose, co-infection and outcomes.
References: PMID: 33849679 / doi: 10.1017/S0950268821000790
Contact Info: Sedighe Karimzadeh: [email protected]; Raj Bhopal: [email protected]
URL: https://www.cambridge.org/core/journals/epidemiology-and-infection/article/revi…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Fudan University, Second Military Medical University, Peking University
Keywords: SARS-CoV-2, cell-based vaccine, neutralizing antibodies, immune response, pathology, mice, primates
Summary of Study: The data present strong evidence supporting the promise of K562-S (a novel cell-based vaccine candidate that uses human cell K562 as a cellular carrier to display Spike (S) protein on the membrane) as a new effective vaccine for the prevention of COVID-19.
References: PMID: 34304724 / doi: 10.1080/22221751.2021.1957400
Contact Info: Jianqing Xu: [email protected]; Xiaoyan Zhang: [email protected]; Chen Zhao: [email protected]; Ping Zhao: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1957400
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Fudan University, Second Military Medical University, Peking University
Keywords: SARS-CoV-2, cell-based vaccine, neutralizing antibodies, immune response, pathology, mice, primates
Summary of Study: The data present strong evidence supporting the promise of K562-S (a novel cell-based vaccine candidate that uses human cell K562 as a cellular carrier to display Spike (S) protein on the membrane) as a new effective vaccine for the prevention of COVID-19.
References: PMID: 34304724 / doi: 10.1080/22221751.2021.1957400
Contact Info: Jianqing Xu: [email protected]; Xiaoyan Zhang: [email protected]; Chen Zhao: [email protected]; Ping Zhao: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1957400
Coronavirus Investigated: SARS-CoV-2
NHP Species: olive baboons
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Novavax, University of Maryland, University of Oklahoma, and others
Keywords: SARS-CoV-2, subunit vaccine (NVX-CoV2373), mice and primates
Summary of Study: Administering a subunit vaccine (NVX-CoV2373) constructed from the full-length S-protein, with Matrix-M adjuvant in a nonhuman primate model induces B- and T-cell responses, hACE2-receptor-blocking antibodies, and SARS-CoV-2 neutralizing antibodies. These results support the clinical development of the NVX-C0V2373 vaccine for prevention of COVID-19.
References: PMID: 33446655 / doi: 10.1038/s41467-020-20653-8
Contact Info: Gale Smith: [email protected]
URL: https://www.nature.com/articles/s41467-020-20653-8
NHP Species: olive baboons
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Novavax, University of Maryland, University of Oklahoma, and others
Keywords: SARS-CoV-2, subunit vaccine (NVX-CoV2373), mice and primates
Summary of Study: Administering a subunit vaccine (NVX-CoV2373) constructed from the full-length S-protein, with Matrix-M adjuvant in a nonhuman primate model induces B- and T-cell responses, hACE2-receptor-blocking antibodies, and SARS-CoV-2 neutralizing antibodies. These results support the clinical development of the NVX-C0V2373 vaccine for prevention of COVID-19.
References: PMID: 33446655 / doi: 10.1038/s41467-020-20653-8
Contact Info: Gale Smith: [email protected]
URL: https://www.nature.com/articles/s41467-020-20653-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Indian Veterinary Research Institute and others
Keywords: SARS-CoV-2, domestic and wild animal species, public health
Summary of Study: This review analyzes the current evidence of SARS-CoV-2 natural infection in domestic and wild animal species and their possible implications on public health.
References: PMID: 33892621 / doi: 10.1080/01652176/2021.1921311
Contact Info: Khan Sharun: [email protected]; Kuldeep Dhama: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128218/pdf/TVEQ_41_1921311.pdf
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Indian Veterinary Research Institute and others
Keywords: SARS-CoV-2, domestic and wild animal species, public health
Summary of Study: This review analyzes the current evidence of SARS-CoV-2 natural infection in domestic and wild animal species and their possible implications on public health.
References: PMID: 33892621 / doi: 10.1080/01652176/2021.1921311
Contact Info: Khan Sharun: [email protected]; Kuldeep Dhama: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128218/pdf/TVEQ_41_1921311.pdf
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Texas Medical Branch
Keywords: SARS-CoV-2, convalescent sera, primates
Summary of Study: Convalescent plasma therapy in humans may be an effective strategy provided that donor sera contain high anti-SARS-CoV-2 neutralizing titers given in early states of the disease.
References: PMID: 33662255 / doi: 10.1016/j.celrep.2021.108837
Contact Info: Thomas W. Geisbert:
URL: https://www.sciencedirect.com/science/article/pii/S2211124721001510?via%3Dihub
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: University of Texas Medical Branch
Keywords: SARS-CoV-2, convalescent sera, primates
Summary of Study: Convalescent plasma therapy in humans may be an effective strategy provided that donor sera contain high anti-SARS-CoV-2 neutralizing titers given in early states of the disease.
References: PMID: 33662255 / doi: 10.1016/j.celrep.2021.108837
Contact Info: Thomas W. Geisbert:
URL: https://www.sciencedirect.com/science/article/pii/S2211124721001510?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Weill Cornell Medical College
Keywords: SARS-CoV-2, vaccines, antibody and T cell immunogenicity, review, primates
Summary of Study: This review article looks at what is known of the antibody and T cell immunogenicity of vaccines that have advanced to human clinical trials. Includes summary of press releases on the outcomes of vaccine efficacy trials.
References: PMID: 33608249 / doi: 10.1126/sciadv.abe8065
Contact Info: John P. Moore: [email protected]
URL: https://advances.sciencemag.org/content/7/12/eabe8065
NHP Species: multiple species
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Weill Cornell Medical College
Keywords: SARS-CoV-2, vaccines, antibody and T cell immunogenicity, review, primates
Summary of Study: This review article looks at what is known of the antibody and T cell immunogenicity of vaccines that have advanced to human clinical trials. Includes summary of press releases on the outcomes of vaccine efficacy trials.
References: PMID: 33608249 / doi: 10.1126/sciadv.abe8065
Contact Info: John P. Moore: [email protected]
URL: https://advances.sciencemag.org/content/7/12/eabe8065
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIH
Keywords: SARS-CoV-2, review, different primate species
Summary of Study: The authors advocate for baboons as a viable alternative to rhesus macaques in SARS-CoV-2 research.
References: PMID: 33785923 / doi:10.1038/s41684-021-00755-6
Contact Info: Michael Chang: [email protected]
URL: https://www.nature.com/articles/s41684-021-00755-6
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: NIH
Keywords: SARS-CoV-2, review, different primate species
Summary of Study: The authors advocate for baboons as a viable alternative to rhesus macaques in SARS-CoV-2 research.
References: PMID: 33785923 / doi:10.1038/s41684-021-00755-6
Contact Info: Michael Chang: [email protected]
URL: https://www.nature.com/articles/s41684-021-00755-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Chinese Academy of Sciences; State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing; Sinocelltech Ltd., National Institutes for Food and Drug Control, Beijing; Institute for Biological Product Control, Beijing
Keywords: SARS-CoV-2, monoclonal antibody, preclinical safety evaluation, cryo-EM structure, mice, primates
Summary of Study: Increasing access to panels of authentic neutralizing monoclonal antibodies will facilitate structure-function studies to unpick the underlying biological processes of virus-host interactions, and provide molecular basis for applying HB27 for potential COVID-19 treatment.
References: PMID: 34676096 / doi: 10.1093/nsr/nwaa297
Contact Info: Cheng-Feng Qin: [email protected]; Xiangxi Wang: [email protected]; Youchun Wang: [email protected]; Zihe Rao: [email protected]; Liangzhi Xie: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798916/
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Chinese Academy of Sciences; State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing; Sinocelltech Ltd., National Institutes for Food and Drug Control, Beijing; Institute for Biological Product Control, Beijing
Keywords: SARS-CoV-2, monoclonal antibody, preclinical safety evaluation, cryo-EM structure, mice, primates
Summary of Study: Increasing access to panels of authentic neutralizing monoclonal antibodies will facilitate structure-function studies to unpick the underlying biological processes of virus-host interactions, and provide molecular basis for applying HB27 for potential COVID-19 treatment.
References: PMID: 34676096 / doi: 10.1093/nsr/nwaa297
Contact Info: Cheng-Feng Qin: [email protected]; Xiangxi Wang: [email protected]; Youchun Wang: [email protected]; Zihe Rao: [email protected]; Liangzhi Xie: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798916/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: California National Primate Research Center; University of California, Davis; Louisiana State University Health Sciences Center; The Rockefeller University.
Keywords: SARS-CoV-2, neuroinflammation, effector CD4 T cells, inflammation, cerebrospinal fluid, pneumonia, primates
Summary of Study: Neutralizing mABs administered preventatively to high-risk populations may mitigate the adverse inflammatory consequences of SARS-CoV-2 exposure.
References: PMID: 34706272 / doi: 10.1016/j.celrep.2021.109942
Contact Info: Smita Iyer: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2211124721014157?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: California National Primate Research Center; University of California, Davis; Louisiana State University Health Sciences Center; The Rockefeller University.
Keywords: SARS-CoV-2, neuroinflammation, effector CD4 T cells, inflammation, cerebrospinal fluid, pneumonia, primates
Summary of Study: Neutralizing mABs administered preventatively to high-risk populations may mitigate the adverse inflammatory consequences of SARS-CoV-2 exposure.
References: PMID: 34706272 / doi: 10.1016/j.celrep.2021.109942
Contact Info: Smita Iyer: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2211124721014157?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Wuhan Institute of Virology, Chinese Academy of Sciences; University of the Chinese Academy of Sciences; Wuhan YZY Biopharma Co., Ltd.
Keywords: SARS-CoV-2, subunit vaccine, immunity, virus load, pathology, primates
Summary of Study: The RBD-homodimer vaccine candidate studied can induce both humoral and cellular response in vivo and prevent SARS-CoV-2 infection in both rodents and non-human primates. Production of this RBD vaccine candidate can be performed in large scale, which will enhance the vaccine supply and warrants future clinical trials.
References: PMID: 34493710 / doi: 10.1038/s41421-021-00320-y
Contact Info: Zhiming Yuan: [email protected]; Chao Shan: [email protected]; Genfu Xiao: [email protected]
URL: https://www.nature.com/articles/s41421-021-00320-y
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Wuhan Institute of Virology, Chinese Academy of Sciences; University of the Chinese Academy of Sciences; Wuhan YZY Biopharma Co., Ltd.
Keywords: SARS-CoV-2, subunit vaccine, immunity, virus load, pathology, primates
Summary of Study: The RBD-homodimer vaccine candidate studied can induce both humoral and cellular response in vivo and prevent SARS-CoV-2 infection in both rodents and non-human primates. Production of this RBD vaccine candidate can be performed in large scale, which will enhance the vaccine supply and warrants future clinical trials.
References: PMID: 34493710 / doi: 10.1038/s41421-021-00320-y
Contact Info: Zhiming Yuan: [email protected]; Chao Shan: [email protected]; Genfu Xiao: [email protected]
URL: https://www.nature.com/articles/s41421-021-00320-y
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Korea Research Institute of Bioscience & Biotechnology, Chonnam National University, Chungbuk National University
Keywords: SARS-CoV-2, virus variants, microevolution, species specific variations, primates
Summary of Study: The genomes of SARS-CoV-2 differ according to individuals and species despite infection of the identical virus in NHPs. These results are important for the interpretation of longitudinal studies evaluating the evolution of the SARS-CoV-2 in humans and development of new diagnostics, vaccine, and therapeutics targeting SARS-CoV-2.
References: PMID: 34305860 / doi: 10.3389/fmicb.2021.694897
Contact Info: Jungjoo Hong: [email protected]; Bon-Sang Koo: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2021.694897/full
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Korea Research Institute of Bioscience & Biotechnology, Chonnam National University, Chungbuk National University
Keywords: SARS-CoV-2, virus variants, microevolution, species specific variations, primates
Summary of Study: The genomes of SARS-CoV-2 differ according to individuals and species despite infection of the identical virus in NHPs. These results are important for the interpretation of longitudinal studies evaluating the evolution of the SARS-CoV-2 in humans and development of new diagnostics, vaccine, and therapeutics targeting SARS-CoV-2.
References: PMID: 34305860 / doi: 10.3389/fmicb.2021.694897
Contact Info: Jungjoo Hong: [email protected]; Bon-Sang Koo: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2021.694897/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Laboratory of Virology, Hamilton, MT; NIAID; University of Plymouth, Plymouth, UK; The Vaccine Group, Ltd.
Keywords: SARS-CoV-2, virus genomic variants, pathology, virus replication, shedding, primates
Summary of Study: Results from the intranasal AGM COVID-19 surrogate model support the most recent data from B.1.1.7 in humans, providing direct empirical data for increased replication in the respiratory tissue, but with no enhancement of disease.
References: PMID: 34724885 / doi: 10.1080/22221751.2021.1997074
Contact Info: Heinz Feldmann: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1997074
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Laboratory of Virology, Hamilton, MT; NIAID; University of Plymouth, Plymouth, UK; The Vaccine Group, Ltd.
Keywords: SARS-CoV-2, virus genomic variants, pathology, virus replication, shedding, primates
Summary of Study: Results from the intranasal AGM COVID-19 surrogate model support the most recent data from B.1.1.7 in humans, providing direct empirical data for increased replication in the respiratory tissue, but with no enhancement of disease.
References: PMID: 34724885 / doi: 10.1080/22221751.2021.1997074
Contact Info: Heinz Feldmann: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1997074
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Amsterdam, Universite Paris-Saclay, University of Southampton, and others
Keywords: SARS-CoV-2, two-component protein nanoparticle vaccine, primates
Summary of Study: A two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein induces potent neutralizing antibody responses in cynomolgus macaques. The vaccine-induced immunity protects macaques against a high-dose challenge, resulting in strongly reduced viral infection and replication in the upper and lower airways. These nanoparticles are a promising vaccine candidate.
References: PMID: 33577765 / doi: 10.1016/j.cell.2021.01.035
Contact Info: Roger Le Grand: [email protected]; Rogier Sanders: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0092867421000787?via%3Dihub
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Amsterdam, Universite Paris-Saclay, University of Southampton, and others
Keywords: SARS-CoV-2, two-component protein nanoparticle vaccine, primates
Summary of Study: A two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein induces potent neutralizing antibody responses in cynomolgus macaques. The vaccine-induced immunity protects macaques against a high-dose challenge, resulting in strongly reduced viral infection and replication in the upper and lower airways. These nanoparticles are a promising vaccine candidate.
References: PMID: 33577765 / doi: 10.1016/j.cell.2021.01.035
Contact Info: Roger Le Grand: [email protected]; Rogier Sanders: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0092867421000787?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Institute of Human Virology, Zhongshan School of Medicine
Keywords: SARS-CoV-2, convalescent sera, receptor-binding domain based nanoparticles, virus variants, primates
Summary of Study: Results show that as mutations accumulate in the RBD, spike proteins may acquire an antigenic shift that enable SARS-CoV-2 variants to eventually resist the current vaccines. Intensive monitoring of virus mutations and timely adjustment of the designed vaccines are required to control the viral pandemic.
References: PMID: 33580167 / doi: 10.1038/s41423-021-00641-8
Contact Info: Xin He: [email protected]
URL: https://www.nature.com/articles/s41423-021-00641-8
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Institute of Human Virology, Zhongshan School of Medicine
Keywords: SARS-CoV-2, convalescent sera, receptor-binding domain based nanoparticles, virus variants, primates
Summary of Study: Results show that as mutations accumulate in the RBD, spike proteins may acquire an antigenic shift that enable SARS-CoV-2 variants to eventually resist the current vaccines. Intensive monitoring of virus mutations and timely adjustment of the designed vaccines are required to control the viral pandemic.
References: PMID: 33580167 / doi: 10.1038/s41423-021-00641-8
Contact Info: Xin He: [email protected]
URL: https://www.nature.com/articles/s41423-021-00641-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: California National Primate Research Center, UC Davis
Keywords: SARS-CoV-2, CD4 T follicular helper (Tfh) cells, primates
Summary of Study: SARC-CoV-2 infection in rhesus macaques, either infused with convalescent plasma, normal plasma, or receiving no infusion showed induction of germinal center (GC) responses.
References: PMID: 33483492 / doi: 10.1038/s41467-020-20642-x
Contact Info: Koen Van Rompay: [email protected]; Smita Iyer: [email protected]
URL: https://www.nature.com/articles/s41467-020-20642-x
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: California National Primate Research Center, UC Davis
Keywords: SARS-CoV-2, CD4 T follicular helper (Tfh) cells, primates
Summary of Study: SARC-CoV-2 infection in rhesus macaques, either infused with convalescent plasma, normal plasma, or receiving no infusion showed induction of germinal center (GC) responses.
References: PMID: 33483492 / doi: 10.1038/s41467-020-20642-x
Contact Info: Koen Van Rompay: [email protected]; Smita Iyer: [email protected]
URL: https://www.nature.com/articles/s41467-020-20642-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Karolinska Institute, University of Cape Town
Keywords: SARS-CoV-2, spike protein subunit vaccine, mice and primates, immune response
Summary of Study: Adjuvanted protein immunization with soluble SARS-CoV-2 Spike trimers, stabilized in prefusion conformation, results in potent antibody responses in mice and rhesus macaques, with neutralizing antibody titers exceeding those typically measured in SARS-CoV-2 seropositive humans by more than one order of magnitude.
References: PMID: 33842900 / doi: 10.1016/j.xcrm.2021.10052
Contact Info: Ben Murrell: [email protected]; Daniel Sheward: [email protected], Gunilla Karlsson Hedestam: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379121000689?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Karolinska Institute, University of Cape Town
Keywords: SARS-CoV-2, spike protein subunit vaccine, mice and primates, immune response
Summary of Study: Adjuvanted protein immunization with soluble SARS-CoV-2 Spike trimers, stabilized in prefusion conformation, results in potent antibody responses in mice and rhesus macaques, with neutralizing antibody titers exceeding those typically measured in SARS-CoV-2 seropositive humans by more than one order of magnitude.
References: PMID: 33842900 / doi: 10.1016/j.xcrm.2021.10052
Contact Info: Ben Murrell: [email protected]; Daniel Sheward: [email protected], Gunilla Karlsson Hedestam: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379121000689?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID; Emory University Vaccine Center; BIOQUAL; Moderna; Johns Hopkins University
Keywords: SARS-CoV-2, variants of concern, booster, immune response, primates
Summary of Study: An additional, delayed boost with mRNA vaccines matched to either the original vaccine strain or to the heterologous challenge strain can have a marked and sustained effect on increasing the breadth of neutralization against all VOCs tested and protection in both the lower and upper airways against the beta variant.
References: PMID: 34672695 / doi: 10.1126/science.abl8912
Contact Info: Robert Seder: [email protected]; Barney Graham: [email protected]
URL: https://www.science.org/doi/10.1126/science.abl8912?url_ver=Z39.88-2003&rfr_id=…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: NIAID; Emory University Vaccine Center; BIOQUAL; Moderna; Johns Hopkins University
Keywords: SARS-CoV-2, variants of concern, booster, immune response, primates
Summary of Study: An additional, delayed boost with mRNA vaccines matched to either the original vaccine strain or to the heterologous challenge strain can have a marked and sustained effect on increasing the breadth of neutralization against all VOCs tested and protection in both the lower and upper airways against the beta variant.
References: PMID: 34672695 / doi: 10.1126/science.abl8912
Contact Info: Robert Seder: [email protected]; Barney Graham: [email protected]
URL: https://www.science.org/doi/10.1126/science.abl8912?url_ver=Z39.88-2003&rfr_id=…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Washington; University of North Carolina at Chapel Hil; Fred Hutchinson Cancer Research Center; Stanford University School of Medicine; Institut Pasteur and CNRS UMR 3569; New Iberia Research Center and Department of Biology; Washington National Primate Research Center; University of Texas at Austin; GSK; Humabs Biomed SA; Bill & Melinda Gates Foundation
Keywords: SARS-CoV-2, vaccine design, spike glycoprotein, receptor-binding domain, self-assembling nanoparticle, sarbecovirus, primates
Summary of Study: This study provides proof of the principle that multivalent sarbecovirus RBD-NPs induce heterotypic protection and motivates advancing such broadly protective sarbecovirus vaccines to the clinic.
References: PMID: 34619077 / doi: 10.1016/j.cell.2021.09.015
Contact Info: Neil King: [email protected]; David Veesler: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S009286742101062X?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Washington; University of North Carolina at Chapel Hil; Fred Hutchinson Cancer Research Center; Stanford University School of Medicine; Institut Pasteur and CNRS UMR 3569; New Iberia Research Center and Department of Biology; Washington National Primate Research Center; University of Texas at Austin; GSK; Humabs Biomed SA; Bill & Melinda Gates Foundation
Keywords: SARS-CoV-2, vaccine design, spike glycoprotein, receptor-binding domain, self-assembling nanoparticle, sarbecovirus, primates
Summary of Study: This study provides proof of the principle that multivalent sarbecovirus RBD-NPs induce heterotypic protection and motivates advancing such broadly protective sarbecovirus vaccines to the clinic.
References: PMID: 34619077 / doi: 10.1016/j.cell.2021.09.015
Contact Info: Neil King: [email protected]; David Veesler: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S009286742101062X?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center, Tulane University School of Medicine, Tulane University, Brigham and Women's Hospital/Harvard Medical School, LSU Health Science Center, Julius-Maximilians-Universitat Wurzburg, and more
Keywords: SARS-CoV-2, endotheliopathy, inflammation, primates, mice
Summary of Study: In addition to pneumocytes, SARS-CoV-2 also directly infects mature vascular endothelial cells in vivo and ex vivo which may contribute to cardiovascular complications in SARS-CoV-2 infection, including multiple organ failure.
References: PMID: 34307198 / doi: 10.3389/fcimb.2021.701278
Contact Info: Xuebin Qin: [email protected]; Suleyman Ergun: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292147/
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center, Tulane University School of Medicine, Tulane University, Brigham and Women's Hospital/Harvard Medical School, LSU Health Science Center, Julius-Maximilians-Universitat Wurzburg, and more
Keywords: SARS-CoV-2, endotheliopathy, inflammation, primates, mice
Summary of Study: In addition to pneumocytes, SARS-CoV-2 also directly infects mature vascular endothelial cells in vivo and ex vivo which may contribute to cardiovascular complications in SARS-CoV-2 infection, including multiple organ failure.
References: PMID: 34307198 / doi: 10.3389/fcimb.2021.701278
Contact Info: Xuebin Qin: [email protected]; Suleyman Ergun: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292147/
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Huazhong University of Science & Technology; Chinese Academy of Sciences; Peking University; Shanghai Junshi Biosciences Co., Ltd.; and others
Keywords: SARS-CoV-2, ACE2-blocking monoclonal antibody, receptor-binding domain, pathology, primates
Summary of Study: The ACE2-blocking MAb represents a broadly promising therapeutic candidate against emergence, re-emergence, and future zoonotic transmission events from SARSr-CoVs and variants.
References: PMID: 34404805 / doi: 10.1038/s41467-021-25331-x
Contact Info: Wenjie Tan: [email protected]
URL: https://www.nature.com/articles/s41467-021-25331-x
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Huazhong University of Science & Technology; Chinese Academy of Sciences; Peking University; Shanghai Junshi Biosciences Co., Ltd.; and others
Keywords: SARS-CoV-2, ACE2-blocking monoclonal antibody, receptor-binding domain, pathology, primates
Summary of Study: The ACE2-blocking MAb represents a broadly promising therapeutic candidate against emergence, re-emergence, and future zoonotic transmission events from SARSr-CoVs and variants.
References: PMID: 34404805 / doi: 10.1038/s41467-021-25331-x
Contact Info: Wenjie Tan: [email protected]
URL: https://www.nature.com/articles/s41467-021-25331-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Ragon Institute of MGH, MIT and Harvard; UNC Chapel Hill; Tufts University; Janssen Vaccines & Prevention.
Keywords: SARS-CoV-2, adenovirus vectored COVID-19 vaccine, humoral and cellular immune responses, genome variants, primates
Summary of Study: The Ad26.COV2.S vaccine provided robust protection against both WA1/2020 and B.1.351 variants.
References: PMID: 34161961 / doi: 10.1038/s41586-021-03732-8
Contact Info: Dan Barouch: [email protected]
URL: https://www.nature.com/articles/s41586-021-03732-8
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School; Ragon Institute of MGH, MIT and Harvard; UNC Chapel Hill; Tufts University; Janssen Vaccines & Prevention.
Keywords: SARS-CoV-2, adenovirus vectored COVID-19 vaccine, humoral and cellular immune responses, genome variants, primates
Summary of Study: The Ad26.COV2.S vaccine provided robust protection against both WA1/2020 and B.1.351 variants.
References: PMID: 34161961 / doi: 10.1038/s41586-021-03732-8
Contact Info: Dan Barouch: [email protected]
URL: https://www.nature.com/articles/s41586-021-03732-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Erasmus Medical Center, Biomedical Primate Research Centre, Utrecht University, Friedrich-Loeffler-Institute, and others
Keywords: SARS-CoV-2, inactivated virus vaccine, immune response, pathology, mice, primates
Summary of Study: The surrogate virus-neutralization test (sVNT) detects high titers of RBD-binding antibodies and thus is potentially useful as an assay for large seroprevalence studies that aim at detecting high titers (vaccination trials or large-scale initial testing of potential animal reservoirs.)
References: PMID: 34458548 / doi: 10.1016/j.onehlt.2021.100313
Contact Info: Carmen Embregts: [email protected]; Corine GeurtsvanKessel: c. [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2352771421001038?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Erasmus Medical Center, Biomedical Primate Research Centre, Utrecht University, Friedrich-Loeffler-Institute, and others
Keywords: SARS-CoV-2, inactivated virus vaccine, immune response, pathology, mice, primates
Summary of Study: The surrogate virus-neutralization test (sVNT) detects high titers of RBD-binding antibodies and thus is potentially useful as an assay for large seroprevalence studies that aim at detecting high titers (vaccination trials or large-scale initial testing of potential animal reservoirs.)
References: PMID: 34458548 / doi: 10.1016/j.onehlt.2021.100313
Contact Info: Carmen Embregts: [email protected]; Corine GeurtsvanKessel: c. [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2352771421001038?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Russian Academy of Sciences; Sechenov First Moscow State Medical University; Lomonosov Moscow State University
Keywords: SARS-CoV-2, inactivated vaccine, long-term humoral immunogenicity, toxicity, mice, hamsters, primates
Summary of Study: A beta-propiolactone-inactivated whole virion vaccine (CoviVac) was asses and showed no signs of acute/chronic, reproductive, embryo- and fetotoxicity or teratogenic effects, as well as no allergenic properties in the animal species studied.
References: PMID: 34427172 / doi: 10.1080/22221751.2021.1971569
Contact Info: Liubov Kozlovskaya: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1971569
NHP Species: marmosets
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Russian Academy of Sciences; Sechenov First Moscow State Medical University; Lomonosov Moscow State University
Keywords: SARS-CoV-2, inactivated vaccine, long-term humoral immunogenicity, toxicity, mice, hamsters, primates
Summary of Study: A beta-propiolactone-inactivated whole virion vaccine (CoviVac) was asses and showed no signs of acute/chronic, reproductive, embryo- and fetotoxicity or teratogenic effects, as well as no allergenic properties in the animal species studied.
References: PMID: 34427172 / doi: 10.1080/22221751.2021.1971569
Contact Info: Liubov Kozlovskaya: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1971569
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: North Carolina State University; UNC-Chapel Hill; BreStem Therapeutics, Bioqual, Inc.
Keywords: SARS-CoV-2, ACE2 nanodecoys, inhalation therapy, mice and primates
Summary of Study: ACE2 nanodecoys derived from human lung spheroid cells (LSCs) can bind and neutralize SARS-CoV-2. In cynomolgus macaques challenged with live SARS-CoV-2, four doses of these nanodecoys delivered by inhalation promoted viral clearance and reduced lung injury. these results suggest that LSC-nanodecoys can serve as a potential therapeutic agent for treating COVID-19.
References: PMID: 34140674 / doi: 10.1038/s41565-021-00923-2
Contact Info: Ke Cheng: [email protected]
URL: https://www.nature.com/articles/s41565-021-00923-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: North Carolina State University; UNC-Chapel Hill; BreStem Therapeutics, Bioqual, Inc.
Keywords: SARS-CoV-2, ACE2 nanodecoys, inhalation therapy, mice and primates
Summary of Study: ACE2 nanodecoys derived from human lung spheroid cells (LSCs) can bind and neutralize SARS-CoV-2. In cynomolgus macaques challenged with live SARS-CoV-2, four doses of these nanodecoys delivered by inhalation promoted viral clearance and reduced lung injury. these results suggest that LSC-nanodecoys can serve as a potential therapeutic agent for treating COVID-19.
References: PMID: 34140674 / doi: 10.1038/s41565-021-00923-2
Contact Info: Ke Cheng: [email protected]
URL: https://www.nature.com/articles/s41565-021-00923-2