Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Henry M. Jackson Foundation for the Advancement of Military Medicine; Washington University; NCI/NIH; BIOQUAL; Texas Biomedical Research Institute; Columbia University Vagelos College of Physicians and Surgeons.
Keywords: SARS-CoV-2, nanoparticle protein vaccine, humoral and cellular immune responses, virus variants, primates
Summary of Study: A ferritin nanoparticle vaccine displaying the receptor-binding domain of the SARS-CoV-2 spike protein adjuvanted with Army Liposomal Formulation QS-21 induces robust and broad antibody and T cell responses, as well as protection against viral replication and lung pathology following high-dose respiratory tract challenge with SARS-CoV-2.
References: PMID: 34470866 / doi: 10.1073/pnas.2106433118
Contact Info: Kayvon Modjarrad: [email protected]; Diane Bolton: [email protected]
URL: https://www.pnas.org/content/118/38/e2106433118.long
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Henry M. Jackson Foundation for the Advancement of Military Medicine; Washington University; NCI/NIH; BIOQUAL; Texas Biomedical Research Institute; Columbia University Vagelos College of Physicians and Surgeons.
Keywords: SARS-CoV-2, nanoparticle protein vaccine, humoral and cellular immune responses, virus variants, primates
Summary of Study: A ferritin nanoparticle vaccine displaying the receptor-binding domain of the SARS-CoV-2 spike protein adjuvanted with Army Liposomal Formulation QS-21 induces robust and broad antibody and T cell responses, as well as protection against viral replication and lung pathology following high-dose respiratory tract challenge with SARS-CoV-2.
References: PMID: 34470866 / doi: 10.1073/pnas.2106433118
Contact Info: Kayvon Modjarrad: [email protected]; Diane Bolton: [email protected]
URL: https://www.pnas.org/content/118/38/e2106433118.long
Coronavirus Investigated: SARS-CoV-2
NHP Species: macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Institute for Basic Science (IBS) (Republic of Kores), Eulji University School of Medicine, Seol National University Hospital, Jeonbuk National University Medical School, Sungkyunkwan University School of Medicine
Keywords: SARS-CoV-2, nasal ciliated cells, virus tropism, primates
Summary of Study: Nasal multiciliated epithelial cells are the main target for SARS-CoV-2 infection and replication in the upper airway during the early stages of COVID-19, implying that targeting nasal ciliated cells could be an ideal strategy to prevent SARS-CoV-2 propagation.
References: PMID: 34003804 / doi: 10.1172/JCI148517
Contact Info: Ji Hoon Ahn: [email protected]; JungMo Kim: [email protected]; Seon Pyo Hong: [email protected]; Young Tae Kim: [email protected], Chang-Seop Lee: [email protected]
URL: https://www.jci.org/articles/view/148517
NHP Species: macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Institute for Basic Science (IBS) (Republic of Kores), Eulji University School of Medicine, Seol National University Hospital, Jeonbuk National University Medical School, Sungkyunkwan University School of Medicine
Keywords: SARS-CoV-2, nasal ciliated cells, virus tropism, primates
Summary of Study: Nasal multiciliated epithelial cells are the main target for SARS-CoV-2 infection and replication in the upper airway during the early stages of COVID-19, implying that targeting nasal ciliated cells could be an ideal strategy to prevent SARS-CoV-2 propagation.
References: PMID: 34003804 / doi: 10.1172/JCI148517
Contact Info: Ji Hoon Ahn: [email protected]; JungMo Kim: [email protected]; Seon Pyo Hong: [email protected]; Young Tae Kim: [email protected], Chang-Seop Lee: [email protected]
URL: https://www.jci.org/articles/view/148517
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Universite Paris-Saclay/Inserm/CEA; Vaccine Research INstitute, Creteil, France; Inserm; Baylor Scott and White Research Institute; Institut Pasteur; Karolinska Institutet; and others
Keywords: SARS-CoV-2, subunit vaccine, receptor-binding domain, immune response, humanized mice, primates
Summary of Study: A single dose of the alphaCD40.RBD (a vaccine that targets the receptor-binding domain of the SARS-CoV-2 spike antigen to the CD40 receptor) administered without adjuvant boosts the protective response in COVID-10 convalescent NHPs.
References: PMID: 34471122 / doi: 10.1038/s41467-021-25382-0
Contact Info: Yves Levy: [email protected]
URL: https://www.nature.com/articles/s41467-021-25382-0
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Universite Paris-Saclay/Inserm/CEA; Vaccine Research INstitute, Creteil, France; Inserm; Baylor Scott and White Research Institute; Institut Pasteur; Karolinska Institutet; and others
Keywords: SARS-CoV-2, subunit vaccine, receptor-binding domain, immune response, humanized mice, primates
Summary of Study: A single dose of the alphaCD40.RBD (a vaccine that targets the receptor-binding domain of the SARS-CoV-2 spike antigen to the CD40 receptor) administered without adjuvant boosts the protective response in COVID-10 convalescent NHPs.
References: PMID: 34471122 / doi: 10.1038/s41467-021-25382-0
Contact Info: Yves Levy: [email protected]
URL: https://www.nature.com/articles/s41467-021-25382-0
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School, University of North Carolina at Chapel Hill, Ragon Institute of MGH, MIT, and Harvard, Massachusetts Consortium on Pathogen Readiness
Keywords: SARS-CoV-2, adenovirus vaccine, immunogenicity and protective efficacy, mice
Summary of Study: RhAd52 vaccines elicit robust SARS-CoV-2 specific antibody responses and protect against clinical disease and viral replication in the lungs. These data validate the MA10 mouse model as a useful tool to screen and study novel vaccine candidates, as well as the development of RhAd52 vaccines for COVID-19.
References: PMID: 34523968 / doi: 10.1128/JVI.00974-21
Contact Info: Dan Barouch: [email protected]
URL: https://journals.asm.org/doi/10.1128/JVI.00974-21?url_ver=Z39.88-2003&rfr_id=or…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Harvard Medical School, University of North Carolina at Chapel Hill, Ragon Institute of MGH, MIT, and Harvard, Massachusetts Consortium on Pathogen Readiness
Keywords: SARS-CoV-2, adenovirus vaccine, immunogenicity and protective efficacy, mice
Summary of Study: RhAd52 vaccines elicit robust SARS-CoV-2 specific antibody responses and protect against clinical disease and viral replication in the lungs. These data validate the MA10 mouse model as a useful tool to screen and study novel vaccine candidates, as well as the development of RhAd52 vaccines for COVID-19.
References: PMID: 34523968 / doi: 10.1128/JVI.00974-21
Contact Info: Dan Barouch: [email protected]
URL: https://journals.asm.org/doi/10.1128/JVI.00974-21?url_ver=Z39.88-2003&rfr_id=or…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Wisconsin National Primate Research Center, Harvard Medical School, Tufts University, BIOQUAL, Ragon Institute of MGH, MIT and Harvard
Keywords: SARS-CoV-2, prior infection, vaccination, virus variants, protection, hamsters, primates
Summary of Study: Data suggest partial but reduced short-term protective efficacy of WA1/2020 natural immunity against SARS-CoV-2 variants of concern. More research is needed to define protective efficacy against other SARS-CoV-2 variants and the immunologic mechanisms of protection against these variants.
References: PMID: 34546094 / doi: 10.1126/scitranslmed.abj2641
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abj2641?url_ver=Z39.88-2003&rf…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Wisconsin National Primate Research Center, Harvard Medical School, Tufts University, BIOQUAL, Ragon Institute of MGH, MIT and Harvard
Keywords: SARS-CoV-2, prior infection, vaccination, virus variants, protection, hamsters, primates
Summary of Study: Data suggest partial but reduced short-term protective efficacy of WA1/2020 natural immunity against SARS-CoV-2 variants of concern. More research is needed to define protective efficacy against other SARS-CoV-2 variants and the immunologic mechanisms of protection against these variants.
References: PMID: 34546094 / doi: 10.1126/scitranslmed.abj2641
Contact Info: Dan Barouch: [email protected]
URL: https://www.science.org/doi/10.1126/scitranslmed.abj2641?url_ver=Z39.88-2003&rf…
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Battelle National Biodefense Institute; Gryphon Scientific LLC; Censeo Insight; Applied Research Associates
Keywords: SARS-CoV-2, inhalation, seroconversion, fever, dose response, primates
Summary of Study: SARS-CoV-2 infection and subsequent disease presentation are dependent on exposure dose in a nonhuman primate model of inhalational COVID-19.
References: PMID: 34424943 / doi: 10.1371/journal.ppat.1009865
Contact Info: Paul Dabisch: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009865
NHP Species:
Year Published: 2021
Study Type/Review:
NPRC/Institute: Battelle National Biodefense Institute; Gryphon Scientific LLC; Censeo Insight; Applied Research Associates
Keywords: SARS-CoV-2, inhalation, seroconversion, fever, dose response, primates
Summary of Study: SARS-CoV-2 infection and subsequent disease presentation are dependent on exposure dose in a nonhuman primate model of inhalational COVID-19.
References: PMID: 34424943 / doi: 10.1371/journal.ppat.1009865
Contact Info: Paul Dabisch: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009865
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: VaxiGen, Inc., Genexine, Inc., Korea National Primate Research Centre, and others
Keywords: SARS-CoV-2, DNA-based vaccine, mice and primates, immune response
Summary of Study: A synthetic soluble SARS-CoV-2 spike (S) DNA-based vaccine candidate, GX-19, provides a durable protective immune response in rhesus macaques, supporting further development of GX-19 as a vaccine candidate for SARS-CoV-2.
References: PMID: 33804981 / doi: 10.3390/vaccines9040307
Contact Info: Yong Bok Seo: [email protected]; You Suk Suh: [email protected]; Jung Joo Hong: [email protected]
URL: https://www.mdpi.com/2076-393X/9/4/307
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: VaxiGen, Inc., Genexine, Inc., Korea National Primate Research Centre, and others
Keywords: SARS-CoV-2, DNA-based vaccine, mice and primates, immune response
Summary of Study: A synthetic soluble SARS-CoV-2 spike (S) DNA-based vaccine candidate, GX-19, provides a durable protective immune response in rhesus macaques, supporting further development of GX-19 as a vaccine candidate for SARS-CoV-2.
References: PMID: 33804981 / doi: 10.3390/vaccines9040307
Contact Info: Yong Bok Seo: [email protected]; You Suk Suh: [email protected]; Jung Joo Hong: [email protected]
URL: https://www.mdpi.com/2076-393X/9/4/307
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Univ. of Pennsylvania Perelman School of Medicine
Keywords: SARS-CoV-2, D614G Spike Mutation, Vaccinated and immune sera, neutralization, primates
Summary of Study: Vaccinated NHPs using the nucleoside-modified mRNA-LNP vaccine platform encoding four differentSARS-CoV-2 spike immunogens generate antibody responses that not only recognize the G614 mutation that has taken over the pandemic, but also have stronger titers of neutralization to this virus variant.
References: PMID: 33306985/doi: 10.1016/j.chom.2020.11.012
Contact Info: Drew Weissman (no contact information)
URL: https://www.sciencedirect.com/science/article/pii/S193131282030634X?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Univ. of Pennsylvania Perelman School of Medicine
Keywords: SARS-CoV-2, D614G Spike Mutation, Vaccinated and immune sera, neutralization, primates
Summary of Study: Vaccinated NHPs using the nucleoside-modified mRNA-LNP vaccine platform encoding four differentSARS-CoV-2 spike immunogens generate antibody responses that not only recognize the G614 mutation that has taken over the pandemic, but also have stronger titers of neutralization to this virus variant.
References: PMID: 33306985/doi: 10.1016/j.chom.2020.11.012
Contact Info: Drew Weissman (no contact information)
URL: https://www.sciencedirect.com/science/article/pii/S193131282030634X?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, inactivated vaccines, antibody-dependent enhancement, immunopathology, primates
Summary of Study: Results show that in the absence of cellular immunity, passive infusion of subneutralizing or nonneutralizing anti-SARS-CoV-2 antibodies could still provide some level of protection against infection upon challenge, and no low-level antibody-enhanced infection was observed.
References: PMID: 34736354 / doi: 10.1080/22221751.2021.2002670
Contact Info: Qihan Li: [email protected]; Longding Liu: [email protected]; Cunbao Liu: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2002670
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, inactivated vaccines, antibody-dependent enhancement, immunopathology, primates
Summary of Study: Results show that in the absence of cellular immunity, passive infusion of subneutralizing or nonneutralizing anti-SARS-CoV-2 antibodies could still provide some level of protection against infection upon challenge, and no low-level antibody-enhanced infection was observed.
References: PMID: 34736354 / doi: 10.1080/22221751.2021.2002670
Contact Info: Qihan Li: [email protected]; Longding Liu: [email protected]; Cunbao Liu: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.2002670
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Nanogen Pharmaceutical Biotechnology Joint Stock Company; National Institute of Hygiene and Epidemiology (Hanoi, Vietnam)
Keywords: SARS-CoV-2, protein subunit vaccine, Nanocovax, pathogenesis, mice, hamsters, primates
Summary of Study: Nanocovax, a SARS-CoV-2 vaccine candidates based on recombinant protein production of the extracellular portion of the spike protein, was shown to be safe and effective in three animal models.
References: PMID: 34938290 / doi: 10.3389/fimmu.2021.766112
Contact Info: Min Si Do: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.766112/full
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Nanogen Pharmaceutical Biotechnology Joint Stock Company; National Institute of Hygiene and Epidemiology (Hanoi, Vietnam)
Keywords: SARS-CoV-2, protein subunit vaccine, Nanocovax, pathogenesis, mice, hamsters, primates
Summary of Study: Nanocovax, a SARS-CoV-2 vaccine candidates based on recombinant protein production of the extracellular portion of the spike protein, was shown to be safe and effective in three animal models.
References: PMID: 34938290 / doi: 10.3389/fimmu.2021.766112
Contact Info: Min Si Do: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.766112/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Yerkes National Primate Research Center, Emory University School of Medicine, Louisiana State University Health Science Center, Texas Children's Center for Vaccine Development, La Jolla Institute for Immunology, and others.
Keywords: SARS-CoV-2, vaccines and adjuvants, immune response, primates
Summary of Study: The adjuvant 3M-052-alum (previously shown to induce better immune responses against HIV) may be a way to improve the efficacy of SARS-CoV-2 vaccines.
References: PMID: 34266981 / doi: 10.1126/sciimmunol.abh3634
Contact Info: Sudhir Pai Kasturi: [email protected]; Maria Elena Bottazzi: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.abh3634?url_ver=Z39.88-2003&rfr_…
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Yerkes National Primate Research Center, Emory University School of Medicine, Louisiana State University Health Science Center, Texas Children's Center for Vaccine Development, La Jolla Institute for Immunology, and others.
Keywords: SARS-CoV-2, vaccines and adjuvants, immune response, primates
Summary of Study: The adjuvant 3M-052-alum (previously shown to induce better immune responses against HIV) may be a way to improve the efficacy of SARS-CoV-2 vaccines.
References: PMID: 34266981 / doi: 10.1126/sciimmunol.abh3634
Contact Info: Sudhir Pai Kasturi: [email protected]; Maria Elena Bottazzi: [email protected]
URL: https://www.science.org/doi/10.1126/sciimmunol.abh3634?url_ver=Z39.88-2003&rfr_…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Wuhan Institute of Virology, Tongji Medical College, University of Chinese Academy of Sciences, Wuhan Institute of Biological Products Co.
Keywords: SARS-CoV-2, inactivated vaccine, mice and primates, immune response
Summary of Study: The authors tested the safety, immunogenicity and efficacy of an inactivated vaccine based on on the whole viral particles in human ACE2 transgenic mouse and in NHPs. This inactivated vaccine successfully induced SARS-CoV-2-specific neutralizing antibodies in both models.
References: PMID: 33835391 / doi: 10.1007/s12250-021-00376-w
Contact Info: Xing-Lou Yang: [email protected]; Shuo Shen: [email protected]; Zhi-Ming Yuan: [email protected]
URL: https://link.springer.com/article/10.1007%2Fs12250-021-00376-w
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Wuhan Institute of Virology, Tongji Medical College, University of Chinese Academy of Sciences, Wuhan Institute of Biological Products Co.
Keywords: SARS-CoV-2, inactivated vaccine, mice and primates, immune response
Summary of Study: The authors tested the safety, immunogenicity and efficacy of an inactivated vaccine based on on the whole viral particles in human ACE2 transgenic mouse and in NHPs. This inactivated vaccine successfully induced SARS-CoV-2-specific neutralizing antibodies in both models.
References: PMID: 33835391 / doi: 10.1007/s12250-021-00376-w
Contact Info: Xing-Lou Yang: [email protected]; Shuo Shen: [email protected]; Zhi-Ming Yuan: [email protected]
URL: https://link.springer.com/article/10.1007%2Fs12250-021-00376-w
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Xiamen University, The University of HongKong, Shantou University, Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, review of the primate models, clinical symptoms, pathogenesis, applications
Summary of Study: Review summarizes the benefits and caveats of NHP models currently available for SARS-CoV-2 and discusses key topics including model optimization, extended application, and clinical translation.
References: PMID: 34490832 / doi: 10.1080/22221751.2021.1976598
Contact Info: Tong Cheng: [email protected]; Ningshao Xia: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1976598
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: Xiamen University, The University of HongKong, Shantou University, Chinese Academy of Medical Sciences
Keywords: SARS-CoV-2, review of the primate models, clinical symptoms, pathogenesis, applications
Summary of Study: Review summarizes the benefits and caveats of NHP models currently available for SARS-CoV-2 and discusses key topics including model optimization, extended application, and clinical translation.
References: PMID: 34490832 / doi: 10.1080/22221751.2021.1976598
Contact Info: Tong Cheng: [email protected]; Ningshao Xia: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1976598
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Kazan State Medical Academy; Kazan State Medical University; Kazan Federal University
Keywords: SARS-CoV-2, infection, pathogenicity, eye surface, literature meta analysis, primates
Summary of Study: There is a possibility of COVID-19 transmission through the eye surface. Eye protection measures should be undertaken when working with potentially infected patients.
References: PMID: 34410064 / doi: 10.17116/oftalma2021137041104
Contact Info: not provided
URL: https://pubmed.ncbi.nlm.nih.gov/34410064/
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Kazan State Medical Academy; Kazan State Medical University; Kazan Federal University
Keywords: SARS-CoV-2, infection, pathogenicity, eye surface, literature meta analysis, primates
Summary of Study: There is a possibility of COVID-19 transmission through the eye surface. Eye protection measures should be undertaken when working with potentially infected patients.
References: PMID: 34410064 / doi: 10.17116/oftalma2021137041104
Contact Info: not provided
URL: https://pubmed.ncbi.nlm.nih.gov/34410064/
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Melbourne, Monash University
Keywords: SARS-CoV-2, prime-boost protein subunit vaccine, mice and primates
Summary of Study: Both S and RBD vaccines are comparably immunogenic and produced strong serological neutralizing responses in pig-tailed macaques. Overall, immunization with recombinant S immunogens reliably elicits potentially protective humoral immunity at levels in excess of those observed in convalescent human, confirming recombinant S proteins as promising vaccine candidates.
References: PMID: 33658497 / doi: 10.1038/s41467-021-21665-8
Contact Info: Stephen Kent: [email protected]
URL: https://www.nature.com/articles/s41467-021-21665-8
NHP Species: pigtail macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Melbourne, Monash University
Keywords: SARS-CoV-2, prime-boost protein subunit vaccine, mice and primates
Summary of Study: Both S and RBD vaccines are comparably immunogenic and produced strong serological neutralizing responses in pig-tailed macaques. Overall, immunization with recombinant S immunogens reliably elicits potentially protective humoral immunity at levels in excess of those observed in convalescent human, confirming recombinant S proteins as promising vaccine candidates.
References: PMID: 33658497 / doi: 10.1038/s41467-021-21665-8
Contact Info: Stephen Kent: [email protected]
URL: https://www.nature.com/articles/s41467-021-21665-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Chinese Academy of Sciences; State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing; Sinocelltech Ltd., National Institutes for Food and Drug Control, Beijing; Institute for Biological Product Control, Beijing
Keywords: SARS-CoV-2, monoclonal antibody, preclinical safety evaluation, cryo-EM structure, mice, primates
Summary of Study: Increasing access to panels of authentic neutralizing monoclonal antibodies will facilitate structure-function studies to unpick the underlying biological processes of virus-host interactions, and provide molecular basis for applying HB27 for potential COVID-19 treatment.
References: PMID: 34676096 / doi: 10.1093/nsr/nwaa297
Contact Info: Cheng-Feng Qin: [email protected]; Xiangxi Wang: [email protected]; Youchun Wang: [email protected]; Zihe Rao: [email protected]; Liangzhi Xie: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798916/
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: Chinese Academy of Sciences; State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing; Sinocelltech Ltd., National Institutes for Food and Drug Control, Beijing; Institute for Biological Product Control, Beijing
Keywords: SARS-CoV-2, monoclonal antibody, preclinical safety evaluation, cryo-EM structure, mice, primates
Summary of Study: Increasing access to panels of authentic neutralizing monoclonal antibodies will facilitate structure-function studies to unpick the underlying biological processes of virus-host interactions, and provide molecular basis for applying HB27 for potential COVID-19 treatment.
References: PMID: 34676096 / doi: 10.1093/nsr/nwaa297
Contact Info: Cheng-Feng Qin: [email protected]; Xiangxi Wang: [email protected]; Youchun Wang: [email protected]; Zihe Rao: [email protected]; Liangzhi Xie: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798916/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: California National Primate Research Center; University of California, Davis; Louisiana State University Health Sciences Center; The Rockefeller University.
Keywords: SARS-CoV-2, neuroinflammation, effector CD4 T cells, inflammation, cerebrospinal fluid, pneumonia, primates
Summary of Study: Neutralizing mABs administered preventatively to high-risk populations may mitigate the adverse inflammatory consequences of SARS-CoV-2 exposure.
References: PMID: 34706272 / doi: 10.1016/j.celrep.2021.109942
Contact Info: Smita Iyer: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2211124721014157?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: prevention
NPRC/Institute: California National Primate Research Center; University of California, Davis; Louisiana State University Health Sciences Center; The Rockefeller University.
Keywords: SARS-CoV-2, neuroinflammation, effector CD4 T cells, inflammation, cerebrospinal fluid, pneumonia, primates
Summary of Study: Neutralizing mABs administered preventatively to high-risk populations may mitigate the adverse inflammatory consequences of SARS-CoV-2 exposure.
References: PMID: 34706272 / doi: 10.1016/j.celrep.2021.109942
Contact Info: Smita Iyer: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2211124721014157?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Wuhan Institute of Virology, Chinese Academy of Sciences; University of the Chinese Academy of Sciences; Wuhan YZY Biopharma Co., Ltd.
Keywords: SARS-CoV-2, subunit vaccine, immunity, virus load, pathology, primates
Summary of Study: The RBD-homodimer vaccine candidate studied can induce both humoral and cellular response in vivo and prevent SARS-CoV-2 infection in both rodents and non-human primates. Production of this RBD vaccine candidate can be performed in large scale, which will enhance the vaccine supply and warrants future clinical trials.
References: PMID: 34493710 / doi: 10.1038/s41421-021-00320-y
Contact Info: Zhiming Yuan: [email protected]; Chao Shan: [email protected]; Genfu Xiao: [email protected]
URL: https://www.nature.com/articles/s41421-021-00320-y
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Wuhan Institute of Virology, Chinese Academy of Sciences; University of the Chinese Academy of Sciences; Wuhan YZY Biopharma Co., Ltd.
Keywords: SARS-CoV-2, subunit vaccine, immunity, virus load, pathology, primates
Summary of Study: The RBD-homodimer vaccine candidate studied can induce both humoral and cellular response in vivo and prevent SARS-CoV-2 infection in both rodents and non-human primates. Production of this RBD vaccine candidate can be performed in large scale, which will enhance the vaccine supply and warrants future clinical trials.
References: PMID: 34493710 / doi: 10.1038/s41421-021-00320-y
Contact Info: Zhiming Yuan: [email protected]; Chao Shan: [email protected]; Genfu Xiao: [email protected]
URL: https://www.nature.com/articles/s41421-021-00320-y
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Korea Research Institute of Bioscience & Biotechnology, Chonnam National University, Chungbuk National University
Keywords: SARS-CoV-2, virus variants, microevolution, species specific variations, primates
Summary of Study: The genomes of SARS-CoV-2 differ according to individuals and species despite infection of the identical virus in NHPs. These results are important for the interpretation of longitudinal studies evaluating the evolution of the SARS-CoV-2 in humans and development of new diagnostics, vaccine, and therapeutics targeting SARS-CoV-2.
References: PMID: 34305860 / doi: 10.3389/fmicb.2021.694897
Contact Info: Jungjoo Hong: [email protected]; Bon-Sang Koo: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2021.694897/full
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Korea Research Institute of Bioscience & Biotechnology, Chonnam National University, Chungbuk National University
Keywords: SARS-CoV-2, virus variants, microevolution, species specific variations, primates
Summary of Study: The genomes of SARS-CoV-2 differ according to individuals and species despite infection of the identical virus in NHPs. These results are important for the interpretation of longitudinal studies evaluating the evolution of the SARS-CoV-2 in humans and development of new diagnostics, vaccine, and therapeutics targeting SARS-CoV-2.
References: PMID: 34305860 / doi: 10.3389/fmicb.2021.694897
Contact Info: Jungjoo Hong: [email protected]; Bon-Sang Koo: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fmicb.2021.694897/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Laboratory of Virology, Hamilton, MT; NIAID; University of Plymouth, Plymouth, UK; The Vaccine Group, Ltd.
Keywords: SARS-CoV-2, virus genomic variants, pathology, virus replication, shedding, primates
Summary of Study: Results from the intranasal AGM COVID-19 surrogate model support the most recent data from B.1.1.7 in humans, providing direct empirical data for increased replication in the respiratory tissue, but with no enhancement of disease.
References: PMID: 34724885 / doi: 10.1080/22221751.2021.1997074
Contact Info: Heinz Feldmann: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1997074
NHP Species: african green monkeys
Year Published: 2021
Study Type/Review:
NPRC/Institute: Laboratory of Virology, Hamilton, MT; NIAID; University of Plymouth, Plymouth, UK; The Vaccine Group, Ltd.
Keywords: SARS-CoV-2, virus genomic variants, pathology, virus replication, shedding, primates
Summary of Study: Results from the intranasal AGM COVID-19 surrogate model support the most recent data from B.1.1.7 in humans, providing direct empirical data for increased replication in the respiratory tissue, but with no enhancement of disease.
References: PMID: 34724885 / doi: 10.1080/22221751.2021.1997074
Contact Info: Heinz Feldmann: [email protected]
URL: https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1997074
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Amsterdam, Universite Paris-Saclay, University of Southampton, and others
Keywords: SARS-CoV-2, two-component protein nanoparticle vaccine, primates
Summary of Study: A two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein induces potent neutralizing antibody responses in cynomolgus macaques. The vaccine-induced immunity protects macaques against a high-dose challenge, resulting in strongly reduced viral infection and replication in the upper and lower airways. These nanoparticles are a promising vaccine candidate.
References: PMID: 33577765 / doi: 10.1016/j.cell.2021.01.035
Contact Info: Roger Le Grand: [email protected]; Rogier Sanders: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0092867421000787?via%3Dihub
NHP Species:
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: University of Amsterdam, Universite Paris-Saclay, University of Southampton, and others
Keywords: SARS-CoV-2, two-component protein nanoparticle vaccine, primates
Summary of Study: A two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein induces potent neutralizing antibody responses in cynomolgus macaques. The vaccine-induced immunity protects macaques against a high-dose challenge, resulting in strongly reduced viral infection and replication in the upper and lower airways. These nanoparticles are a promising vaccine candidate.
References: PMID: 33577765 / doi: 10.1016/j.cell.2021.01.035
Contact Info: Roger Le Grand: [email protected]; Rogier Sanders: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0092867421000787?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Institute of Human Virology, Zhongshan School of Medicine
Keywords: SARS-CoV-2, convalescent sera, receptor-binding domain based nanoparticles, virus variants, primates
Summary of Study: Results show that as mutations accumulate in the RBD, spike proteins may acquire an antigenic shift that enable SARS-CoV-2 variants to eventually resist the current vaccines. Intensive monitoring of virus mutations and timely adjustment of the designed vaccines are required to control the viral pandemic.
References: PMID: 33580167 / doi: 10.1038/s41423-021-00641-8
Contact Info: Xin He: [email protected]
URL: https://www.nature.com/articles/s41423-021-00641-8
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Institute of Human Virology, Zhongshan School of Medicine
Keywords: SARS-CoV-2, convalescent sera, receptor-binding domain based nanoparticles, virus variants, primates
Summary of Study: Results show that as mutations accumulate in the RBD, spike proteins may acquire an antigenic shift that enable SARS-CoV-2 variants to eventually resist the current vaccines. Intensive monitoring of virus mutations and timely adjustment of the designed vaccines are required to control the viral pandemic.
References: PMID: 33580167 / doi: 10.1038/s41423-021-00641-8
Contact Info: Xin He: [email protected]
URL: https://www.nature.com/articles/s41423-021-00641-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: California National Primate Research Center, UC Davis
Keywords: SARS-CoV-2, CD4 T follicular helper (Tfh) cells, primates
Summary of Study: SARC-CoV-2 infection in rhesus macaques, either infused with convalescent plasma, normal plasma, or receiving no infusion showed induction of germinal center (GC) responses.
References: PMID: 33483492 / doi: 10.1038/s41467-020-20642-x
Contact Info: Koen Van Rompay: [email protected]; Smita Iyer: [email protected]
URL: https://www.nature.com/articles/s41467-020-20642-x
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: California National Primate Research Center, UC Davis
Keywords: SARS-CoV-2, CD4 T follicular helper (Tfh) cells, primates
Summary of Study: SARC-CoV-2 infection in rhesus macaques, either infused with convalescent plasma, normal plasma, or receiving no infusion showed induction of germinal center (GC) responses.
References: PMID: 33483492 / doi: 10.1038/s41467-020-20642-x
Contact Info: Koen Van Rompay: [email protected]; Smita Iyer: [email protected]
URL: https://www.nature.com/articles/s41467-020-20642-x
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Karolinska Institute, University of Cape Town
Keywords: SARS-CoV-2, spike protein subunit vaccine, mice and primates, immune response
Summary of Study: Adjuvanted protein immunization with soluble SARS-CoV-2 Spike trimers, stabilized in prefusion conformation, results in potent antibody responses in mice and rhesus macaques, with neutralizing antibody titers exceeding those typically measured in SARS-CoV-2 seropositive humans by more than one order of magnitude.
References: PMID: 33842900 / doi: 10.1016/j.xcrm.2021.10052
Contact Info: Ben Murrell: [email protected]; Daniel Sheward: [email protected], Gunilla Karlsson Hedestam: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379121000689?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: vaccine
NPRC/Institute: Karolinska Institute, University of Cape Town
Keywords: SARS-CoV-2, spike protein subunit vaccine, mice and primates, immune response
Summary of Study: Adjuvanted protein immunization with soluble SARS-CoV-2 Spike trimers, stabilized in prefusion conformation, results in potent antibody responses in mice and rhesus macaques, with neutralizing antibody titers exceeding those typically measured in SARS-CoV-2 seropositive humans by more than one order of magnitude.
References: PMID: 33842900 / doi: 10.1016/j.xcrm.2021.10052
Contact Info: Ben Murrell: [email protected]; Daniel Sheward: [email protected], Gunilla Karlsson Hedestam: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S2666379121000689?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences
Keywords: SARS-CoV-2, combined intratracheal and intranasal inoculation, virus load, primates
Summary of Study: Nasal infection may be regarded as an important index to assess the severity of COVID-19. Furthermore, treatments focused on nasal infection, like hypertonic saline nasal irrigation and gargling, should be considered as a therapeutic option for COVID-19.
References: PMID: 33587263 / doi: 10.1007/s11427-020-1877-4
Contact Info: Yong-Tang Zheng: [email protected]
URL: https://link.springer.com/article/10.1007%2Fs11427-020-1877-4
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences
Keywords: SARS-CoV-2, combined intratracheal and intranasal inoculation, virus load, primates
Summary of Study: Nasal infection may be regarded as an important index to assess the severity of COVID-19. Furthermore, treatments focused on nasal infection, like hypertonic saline nasal irrigation and gargling, should be considered as a therapeutic option for COVID-19.
References: PMID: 33587263 / doi: 10.1007/s11427-020-1877-4
Contact Info: Yong-Tang Zheng: [email protected]
URL: https://link.springer.com/article/10.1007%2Fs11427-020-1877-4
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, primates, animal resources, biosafety
Summary of Study: Sustaining and increasing NHP research capacity will require careful preparation and collaborations to improve existing infrastructure and expand established facilities, expertise, and programs.
References: PMID: 33927412 / doi: 10.1038/s41684-021-00760-9
Contact Info: Sheri Ann Hild: [email protected]
URL: https://www.nature.com/articles/s41684-021-00760-9
NHP Species: multiple species
Year Published: 2021
Study Type/Review:
NPRC/Institute: ORIP/NIH
Keywords: SARS-CoV-2, primates, animal resources, biosafety
Summary of Study: Sustaining and increasing NHP research capacity will require careful preparation and collaborations to improve existing infrastructure and expand established facilities, expertise, and programs.
References: PMID: 33927412 / doi: 10.1038/s41684-021-00760-9
Contact Info: Sheri Ann Hild: [email protected]
URL: https://www.nature.com/articles/s41684-021-00760-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: therapeutics
NPRC/Institute: Chinese Academy of Medical Science and Peking Union Medical College; Genuine Biotech, Inc.; Wuhan Research Center for Infectious Diseases and Cancer; The First Affiliated Hospital of Henan University of Chinese Medicine; Henan Provincial Peoples Hospital; Henan Normal University; Zhengzhou University
Keywords: SARS-CoV-2, Azvudine, preclinical studies, Phase III trial, humans, primates
Summary of Study: Treating SARS-CoV-2 infected rhesus macaques with FNC reduced viral load, recuperated the thymus, improved lymphocyte profiles, alleviated inflammation and organ damage, and lessened ground-glass opacities in chest X-ray.
References: PMID: 34873151 / doi: 10.1038/s41392-021-00835-6
Contact Info: Zhenshun Cheng: [email protected]; Jun-Biao Chang: [email protected]; Jian-Dong Jiang: [email protected]
URL: https://www.nature.com/articles/s41392-021-00835-6
NHP Species: rhesus macaques
Year Published: 2021
Study Type/Review: therapeutics
NPRC/Institute: Chinese Academy of Medical Science and Peking Union Medical College; Genuine Biotech, Inc.; Wuhan Research Center for Infectious Diseases and Cancer; The First Affiliated Hospital of Henan University of Chinese Medicine; Henan Provincial Peoples Hospital; Henan Normal University; Zhengzhou University
Keywords: SARS-CoV-2, Azvudine, preclinical studies, Phase III trial, humans, primates
Summary of Study: Treating SARS-CoV-2 infected rhesus macaques with FNC reduced viral load, recuperated the thymus, improved lymphocyte profiles, alleviated inflammation and organ damage, and lessened ground-glass opacities in chest X-ray.
References: PMID: 34873151 / doi: 10.1038/s41392-021-00835-6
Contact Info: Zhenshun Cheng: [email protected]; Jun-Biao Chang: [email protected]; Jian-Dong Jiang: [email protected]
URL: https://www.nature.com/articles/s41392-021-00835-6
Coronavirus Investigated: SARS-CoV, SARS-CoV-2, MERS-CoV
NHP Species: multiple species
Year Published: 2020
Study Type/Review:
NPRC/Institute: National Institute of Diagnostics and Vaccine Development, School of Public Health, Xiamen University, China
Keywords: coronavirus, infectious disease, respiratory syndrome, animal model, vaccine, drug discovery
Summary of Study: The authors reviewed a variety of animal models, including NHPs. Individual NHP studies are represented elsewhere in this document.
References: doi: 10.1080/22221751.2020.1764871; PMID: 32378471
Contact Info: Yuan L, et al.; correspondence to Ningshao Xia ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32378471/
NHP Species: multiple species
Year Published: 2020
Study Type/Review:
NPRC/Institute: National Institute of Diagnostics and Vaccine Development, School of Public Health, Xiamen University, China
Keywords: coronavirus, infectious disease, respiratory syndrome, animal model, vaccine, drug discovery
Summary of Study: The authors reviewed a variety of animal models, including NHPs. Individual NHP studies are represented elsewhere in this document.
References: doi: 10.1080/22221751.2020.1764871; PMID: 32378471
Contact Info: Yuan L, et al.; correspondence to Ningshao Xia ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32378471/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Mabwell Bioscience, Shanghai, China
Keywords: SARS-CoV-2, therapeutics, neutralizing antibody, primates
Summary of Study: A single dose of monoclonal antibody MW05 (after introducing mutation to the Fc region)Â blocks infection of SARS-CoV-2 in prophylactic treatment and clears SARS-CoV-2 in three days in rhesus monkeys.
References: PMID: 33188207/doi: 10.1038/s41467-020-19568-1
Contact Info: Datao Liu: [email protected]
URL: https://www.nature.com/articles/s41467-020-19568-1
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Mabwell Bioscience, Shanghai, China
Keywords: SARS-CoV-2, therapeutics, neutralizing antibody, primates
Summary of Study: A single dose of monoclonal antibody MW05 (after introducing mutation to the Fc region)Â blocks infection of SARS-CoV-2 in prophylactic treatment and clears SARS-CoV-2 in three days in rhesus monkeys.
References: PMID: 33188207/doi: 10.1038/s41467-020-19568-1
Contact Info: Datao Liu: [email protected]
URL: https://www.nature.com/articles/s41467-020-19568-1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Tulane NPRC
Keywords: SARS-CoV-2, immune response, from acute state up to four weeks post infection, primates
Summary of Study: This study uncovers critical steps in the immune events of the host response to SARS-CoV-2 and describes the correlates of viral replication and disease progression. The authors show viral driven inflammation/cell recruitment to the lung occurs rapidly, and lasts up to 4 weeks post-infection. Results suggest that NHP may be appropriate models to test immune therapies.
References: PMID: 33247138/doi: 10.1038/s41467-020-19967-4
Contact Info: M. Vaccari: [email protected]
URL: https://www.nature.com/articles/s41467-020-19967-4
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Tulane NPRC
Keywords: SARS-CoV-2, immune response, from acute state up to four weeks post infection, primates
Summary of Study: This study uncovers critical steps in the immune events of the host response to SARS-CoV-2 and describes the correlates of viral replication and disease progression. The authors show viral driven inflammation/cell recruitment to the lung occurs rapidly, and lasts up to 4 weeks post-infection. Results suggest that NHP may be appropriate models to test immune therapies.
References: PMID: 33247138/doi: 10.1038/s41467-020-19967-4
Contact Info: M. Vaccari: [email protected]
URL: https://www.nature.com/articles/s41467-020-19967-4
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: KU Leuven, Belgium
Keywords: SARS-CoV-2, live virus-vectored vaccine candidate, primates
Summary of Study: Vaccine candidate YF-SO (a live virus-vectored SARS-CoV-2 vaccine candidate using the yellow fever 17D(YF17D) vaccine as a vector to express a non-cleavable prefusion form of the SARS-CoV-2 Spike antigen) prevents infection with SARS-CoV-2 in a stringent hamster model as well as in non-human primates.
References: PMID: 33260195/doi: 10.1038/s41586-020-3035-9
Contact Info: Johan Neyts: [email protected]
URL: https://www.nature.com/articles/s41586-020-3035-9
NHP Species:
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: KU Leuven, Belgium
Keywords: SARS-CoV-2, live virus-vectored vaccine candidate, primates
Summary of Study: Vaccine candidate YF-SO (a live virus-vectored SARS-CoV-2 vaccine candidate using the yellow fever 17D(YF17D) vaccine as a vector to express a non-cleavable prefusion form of the SARS-CoV-2 Spike antigen) prevents infection with SARS-CoV-2 in a stringent hamster model as well as in non-human primates.
References: PMID: 33260195/doi: 10.1038/s41586-020-3035-9
Contact Info: Johan Neyts: [email protected]
URL: https://www.nature.com/articles/s41586-020-3035-9
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Yerkes NPRC
Keywords: SARS-CoV-2, Baricitinib, immunologic and virologic efficacy, primates
Summary of Study: The authors investigated the immunologic and virologic efficacy of baricitinib in a rhesus macaque model of SARS-CoV-2 infection. Animals treated with baricitinib showed reduced inflammation, decreased lung infiltration of inflammatory cells, reduced NETosis activity, and more limited lung pathology. These data support a beneficial role for the use of baricitinib as a frontline treatment for inflammation induced by SARS-CoV-2 infection.
References: PMID: 33278358/doi: 10.1016/j.cell.2020.11.007
Contact Info: Steven Bosinger: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0092867420314665?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Yerkes NPRC
Keywords: SARS-CoV-2, Baricitinib, immunologic and virologic efficacy, primates
Summary of Study: The authors investigated the immunologic and virologic efficacy of baricitinib in a rhesus macaque model of SARS-CoV-2 infection. Animals treated with baricitinib showed reduced inflammation, decreased lung infiltration of inflammatory cells, reduced NETosis activity, and more limited lung pathology. These data support a beneficial role for the use of baricitinib as a frontline treatment for inflammation induced by SARS-CoV-2 infection.
References: PMID: 33278358/doi: 10.1016/j.cell.2020.11.007
Contact Info: Steven Bosinger: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S0092867420314665?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria
Keywords: SARS-CoV-2, vaccine, receptor binding domain, mice, primates
Summary of Study: Prime-boost protein subunit vaccines against SARS-CoV-2 are highly immunogenic in mice and macaques
References: doi: 10.1101/2020.09.01.278630
Contact Info: Hyon-Xhi Tan et al; Adam K Wheatley, [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.09.01.278630v1
NHP Species: pigtail macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria
Keywords: SARS-CoV-2, vaccine, receptor binding domain, mice, primates
Summary of Study: Prime-boost protein subunit vaccines against SARS-CoV-2 are highly immunogenic in mice and macaques
References: doi: 10.1101/2020.09.01.278630
Contact Info: Hyon-Xhi Tan et al; Adam K Wheatley, [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.09.01.278630v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Institute of Medical Biology, Chinese Academy of Medicine Science & Peking Union Medical College
Keywords: SARS-CoV-2, SARS-CoV-2 inactivated vaccine, immune response
Summary of Study: Immunization of rhesus macaques with a SARS-CoV-2 inactivated vaccine elicited effective immunity with indexes of humoral and cellular reactions.
References: doi: 10.1101/2020.08.04.235747
Contact Info: Hongbo Chen, et al; correspondence to Quhan Li, [email protected] or Longding Liu, [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.08.04.235747v1
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Institute of Medical Biology, Chinese Academy of Medicine Science & Peking Union Medical College
Keywords: SARS-CoV-2, SARS-CoV-2 inactivated vaccine, immune response
Summary of Study: Immunization of rhesus macaques with a SARS-CoV-2 inactivated vaccine elicited effective immunity with indexes of humoral and cellular reactions.
References: doi: 10.1101/2020.08.04.235747
Contact Info: Hongbo Chen, et al; correspondence to Quhan Li, [email protected] or Longding Liu, [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.08.04.235747v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Oregon National Primate Research Center, Harvard, and others
Keywords: coronavirus, SARS-CoV-2, protective immunity
Summary of Study: Rhesus macaques were inoculated intranasally and intratracheally with SARS-CoV-2, which induced humoral and cellular immune responses and provided protective efficacy against SARS-CoV-2 rechallenge. These data raise the possibility that immunologic approaches to the prevention and treatment of SARS-CoV-2 may be effective.
References: doi: 10.1126/science.abc4776; PMID: 32434946
Contact Info: Chandrashekar A, et al.; correspondence to Dan H. Barouch ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32434946/
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Oregon National Primate Research Center, Harvard, and others
Keywords: coronavirus, SARS-CoV-2, protective immunity
Summary of Study: Rhesus macaques were inoculated intranasally and intratracheally with SARS-CoV-2, which induced humoral and cellular immune responses and provided protective efficacy against SARS-CoV-2 rechallenge. These data raise the possibility that immunologic approaches to the prevention and treatment of SARS-CoV-2 may be effective.
References: doi: 10.1126/science.abc4776; PMID: 32434946
Contact Info: Chandrashekar A, et al.; correspondence to Dan H. Barouch ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32434946/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: South Valley Univ., Qena, Egypt
Keywords: SARS-CoV-2, many species, review
Summary of Study: This article reviews the possible animal reservoirs of SARS-CoV-2, as well as best suited models for further study.
References: PMID: 33363234/doi: 10.3389/fvets.2020.596391
Contact Info: Mohamed Mahdy: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fvets.2020.596391/full
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: South Valley Univ., Qena, Egypt
Keywords: SARS-CoV-2, many species, review
Summary of Study: This article reviews the possible animal reservoirs of SARS-CoV-2, as well as best suited models for further study.
References: PMID: 33363234/doi: 10.3389/fvets.2020.596391
Contact Info: Mohamed Mahdy: [email protected]
URL: https://www.frontiersin.org/articles/10.3389/fvets.2020.596391/full
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2020
Study Type/Review:
NPRC/Institute: University of Calgary
Keywords: coronavirus, SARS-CoV-2, ACE2, nonhuman primate
Summary of Study: Authors conducted a study to show that all NHPs exhibit the same set of twelve key amino acid residues as human ACE2, putting them at danger of infection from humans.
References: doi: 10.1101/2020.04.09.034967
Contact Info: Melin AD, et al.; correspondence to Amanda Melin ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32511330/
NHP Species: multiple species
Year Published: 2020
Study Type/Review:
NPRC/Institute: University of Calgary
Keywords: coronavirus, SARS-CoV-2, ACE2, nonhuman primate
Summary of Study: Authors conducted a study to show that all NHPs exhibit the same set of twelve key amino acid residues as human ACE2, putting them at danger of infection from humans.
References: doi: 10.1101/2020.04.09.034967
Contact Info: Melin AD, et al.; correspondence to Amanda Melin ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32511330/
Coronavirus Investigated: SARS-CoV-2, SARS-CoV
NHP Species: multiple species
Year Published: 2020
Study Type/Review:
NPRC/Institute: NIAID
Keywords: beta coronaviruses, SARS-CoV-2, receptor sequence binding
Summary of Study: Authors show that host protease processing during viral entry is a significant barrier for several lineage B viruses and that bypassing this barrier allows several lineage B viruses to enter human cells through an unknown receptor. They also demonstrate how different lineage B viruses can recombine to gain entry into human cells, and confirm that human ACE2 is the receptor for the recently emerging SARS-CoV-2.
References: doi: 10.1038/s41564-020-0688-y
Contact Info: Letko M, et al.; correspondence to Michael Letko ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32094589/
NHP Species: multiple species
Year Published: 2020
Study Type/Review:
NPRC/Institute: NIAID
Keywords: beta coronaviruses, SARS-CoV-2, receptor sequence binding
Summary of Study: Authors show that host protease processing during viral entry is a significant barrier for several lineage B viruses and that bypassing this barrier allows several lineage B viruses to enter human cells through an unknown receptor. They also demonstrate how different lineage B viruses can recombine to gain entry into human cells, and confirm that human ACE2 is the receptor for the recently emerging SARS-CoV-2.
References: doi: 10.1038/s41564-020-0688-y
Contact Info: Letko M, et al.; correspondence to Michael Letko ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32094589/
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: University of Washington, Washington National Primate Research Center
Keywords: coronavirus, SARS-CoV-2, vaccine, RNA, replicon, nanoparticle, nonhuman primate
Summary of Study: Single-dose intramuscular vaccination with LION/repRNA-CoV2S elicited antibody responses that potently neutralized SARS-CoV-2 in pigtail macaques.
References: doi: 10.1101/2020.05.28.121640; Preprint
Contact Info: Erasmus JH, et al.; correspondence to Deborah Fuller ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32511417/
NHP Species: pigtail macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: University of Washington, Washington National Primate Research Center
Keywords: coronavirus, SARS-CoV-2, vaccine, RNA, replicon, nanoparticle, nonhuman primate
Summary of Study: Single-dose intramuscular vaccination with LION/repRNA-CoV2S elicited antibody responses that potently neutralized SARS-CoV-2 in pigtail macaques.
References: doi: 10.1101/2020.05.28.121640; Preprint
Contact Info: Erasmus JH, et al.; correspondence to Deborah Fuller ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32511417/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Institute of Human Virology, Guangdong, China
Keywords: SARS-CoV-2, nanoparticle vaccine, primates
Summary of Study: Nanoparticle vaccines (developed by covalently conjugating the self-assembled 24-mer ferritin to the receptor binding domain (RBD) and/or heptad repeat (HR) subunits of the SARS-CoV-2 spike protein) induced neutralizing antibodies, and T and B cell responses prior to boost immunization in rhesus macaques.
References: PMID: 33275896/doi: 10.1016/j.immuni.2020.11.015
Contact Info: Hui Zhang: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1074761320305021?via%3Dihub
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Institute of Human Virology, Guangdong, China
Keywords: SARS-CoV-2, nanoparticle vaccine, primates
Summary of Study: Nanoparticle vaccines (developed by covalently conjugating the self-assembled 24-mer ferritin to the receptor binding domain (RBD) and/or heptad repeat (HR) subunits of the SARS-CoV-2 spike protein) induced neutralizing antibodies, and T and B cell responses prior to boost immunization in rhesus macaques.
References: PMID: 33275896/doi: 10.1016/j.immuni.2020.11.015
Contact Info: Hui Zhang: [email protected]
URL: https://www.sciencedirect.com/science/article/pii/S1074761320305021?via%3Dihub
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2020
Study Type/Review:
NPRC/Institute: University of Minnesota
Keywords: 2019-nCoV, SARS coronavirus, ACE2, animal reservoir, cross-species transmission, human-to-human transmission
Summary of Study: The authors' decade-long structural studies on the receptor recognition by SARS-CoV have identified key interactions between SARS-CoV spike protein and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of SARS-CoV.
References: doi: 10.1128/JVI.00127-20
Contact Info: Wan Y, et al.; correspondence to Fang Li ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/31996437/
NHP Species: multiple species
Year Published: 2020
Study Type/Review:
NPRC/Institute: University of Minnesota
Keywords: 2019-nCoV, SARS coronavirus, ACE2, animal reservoir, cross-species transmission, human-to-human transmission
Summary of Study: The authors' decade-long structural studies on the receptor recognition by SARS-CoV have identified key interactions between SARS-CoV spike protein and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of SARS-CoV.
References: doi: 10.1128/JVI.00127-20
Contact Info: Wan Y, et al.; correspondence to Fang Li ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/31996437/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: NIAID
Keywords: coronavirus, SARS-CoV-2, animal models, viral load, nonhuman primate
Summary of Study: Rhesus macaques were inoculated with SARS-CoV-2 (isolate nCoV WA1-2020). Data established that the rhesus macaque recapitulates human disease with respect to virus replication and shedding, the presence of pulmonary infiltrates, histological lesions and seroconversion.
References: doi: 10.1038/s41586-020-2324-7; PMID: 32396922
Contact Info: Munster VJ, et al.; correspondence to Emmie de Wit ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32396922/
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: NIAID
Keywords: coronavirus, SARS-CoV-2, animal models, viral load, nonhuman primate
Summary of Study: Rhesus macaques were inoculated with SARS-CoV-2 (isolate nCoV WA1-2020). Data established that the rhesus macaque recapitulates human disease with respect to virus replication and shedding, the presence of pulmonary infiltrates, histological lesions and seroconversion.
References: doi: 10.1038/s41586-020-2324-7; PMID: 32396922
Contact Info: Munster VJ, et al.; correspondence to Emmie de Wit ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32396922/
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Japan
Keywords: SARS-CoV-2, pathogenicity, primates
Summary of Study: Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques
References: doi:10.1101/2020.08.18.256446
Contact Info: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.08.18.256446v1
NHP Species:
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Japan
Keywords: SARS-CoV-2, pathogenicity, primates
Summary of Study: Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques
References: doi:10.1101/2020.08.18.256446
Contact Info: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.08.18.256446v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases
Keywords: coronavirus, SARS-CoV-2, nonhuman primate, neutralizing antibodies
Summary of Study: Rhesus macaques were inoculated intratracheally with SARS-CoV-2/WH-09/human/2020/CHN. Neutralizing antibodies against SARS CoV-2 might protect rhesus macaques which have undergone an initial infection from reinfection during early recovery days.
References: doi: 10.1101/2020.03.13.990226; Preprint
Contact Info: Bao L, et al.; correspondence to Chuan Qin ([email protected])
URL: https://www.biorxiv.org/content/10.1101/2020.03.13.990226v2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases
Keywords: coronavirus, SARS-CoV-2, nonhuman primate, neutralizing antibodies
Summary of Study: Rhesus macaques were inoculated intratracheally with SARS-CoV-2/WH-09/human/2020/CHN. Neutralizing antibodies against SARS CoV-2 might protect rhesus macaques which have undergone an initial infection from reinfection during early recovery days.
References: doi: 10.1101/2020.03.13.990226; Preprint
Contact Info: Bao L, et al.; correspondence to Chuan Qin ([email protected])
URL: https://www.biorxiv.org/content/10.1101/2020.03.13.990226v2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Oregon National Primate Research Center, Harvard, and others
Keywords: coronavirus, SARS-CoV-2, vaccine, nonhuman primate
Summary of Study: A series of DNA vaccine candidates expressing different forms of the SARS-CoV-2 Spike (S) protein were evaluated in rhesus macaques. Vaccine-elicited neutralizing antibody titers correlated with protective efficacy, demonstrating vaccine protection against SARS-CoV-2 in NHPs.
References: doi: 10.1126/science.abc6284; PMID: 32434945
Contact Info: Yu, et al.; correspondence to Dan H. Barouch ([email protected]
URL: https://pubmed.ncbi.nlm.nih.gov/32434945/
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review: vaccine
NPRC/Institute: Oregon National Primate Research Center, Harvard, and others
Keywords: coronavirus, SARS-CoV-2, vaccine, nonhuman primate
Summary of Study: A series of DNA vaccine candidates expressing different forms of the SARS-CoV-2 Spike (S) protein were evaluated in rhesus macaques. Vaccine-elicited neutralizing antibody titers correlated with protective efficacy, demonstrating vaccine protection against SARS-CoV-2 in NHPs.
References: doi: 10.1126/science.abc6284; PMID: 32434945
Contact Info: Yu, et al.; correspondence to Dan H. Barouch ([email protected]
URL: https://pubmed.ncbi.nlm.nih.gov/32434945/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Institute of Medical Biology, Yunnan Province, China
Keywords: SARS-CoV-2, pathogenesis, nasal route of infection. T cells, primates
Summary of Study: Rhesus macaques were infected with SARS-CoV-2 via the nasal route. Data suggested that T cell response and cytokine/chemokine changes in lungs should be considered as evaluation parameters for COVID-19 treatment and vaccine development (in addition to observation of virus shedding and pathological analysis).
References: PMID: 33180882/doi: 10.1371/journal.ppat.1008949
Contact Info: Zhanlong He: [email protected] & Qihan Li: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1008949
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Institute of Medical Biology, Yunnan Province, China
Keywords: SARS-CoV-2, pathogenesis, nasal route of infection. T cells, primates
Summary of Study: Rhesus macaques were infected with SARS-CoV-2 via the nasal route. Data suggested that T cell response and cytokine/chemokine changes in lungs should be considered as evaluation parameters for COVID-19 treatment and vaccine development (in addition to observation of virus shedding and pathological analysis).
References: PMID: 33180882/doi: 10.1371/journal.ppat.1008949
Contact Info: Zhanlong He: [email protected] & Qihan Li: [email protected]
URL: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1008949
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published: 2020
Study Type/Review:
NPRC/Institute: University of Texas Medical Branch
Keywords: SARS-CoV-2, pathogenesis, primates
Summary of Study: African green monkeys support robust SARS-CoV-2 replication and develop pronounced respiratory disease, which may more accurately reflect human COVID-19 cases than other nonhuman primate species.
References: PMID: 33235385/doi: 10.1038/s41590-020-00835-8
Contact Info: Thomas Geisbert: [email protected]
URL: https://www.nature.com/articles/s41590-020-00835-8
NHP Species: african green monkeys
Year Published: 2020
Study Type/Review:
NPRC/Institute: University of Texas Medical Branch
Keywords: SARS-CoV-2, pathogenesis, primates
Summary of Study: African green monkeys support robust SARS-CoV-2 replication and develop pronounced respiratory disease, which may more accurately reflect human COVID-19 cases than other nonhuman primate species.
References: PMID: 33235385/doi: 10.1038/s41590-020-00835-8
Contact Info: Thomas Geisbert: [email protected]
URL: https://www.nature.com/articles/s41590-020-00835-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Chinese Ministry of Health
Keywords: coronavirus, SARS-CoV-2, viral transmission, nonhuman primate
Summary of Study: Rhesus macaques were inoculated with SARS-CoV-2/WH-09/human/2020/CHN via conjunctival, intratracheal, and intragastric routes. Results suggest that conjunctiva is a potential portal for viral transmission; virus was also detected after IT inoculation. No virus was detected after IG inoculation.
References: doi: 10.1101/2020.03.13.990036; Preprint
Contact Info: Deng W, et al.; correspondence to Chuan Qin ([email protected])
URL: https://www.biorxiv.org/content/10.1101/2020.03.13.990036v2.full
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: Chinese Ministry of Health
Keywords: coronavirus, SARS-CoV-2, viral transmission, nonhuman primate
Summary of Study: Rhesus macaques were inoculated with SARS-CoV-2/WH-09/human/2020/CHN via conjunctival, intratracheal, and intragastric routes. Results suggest that conjunctiva is a potential portal for viral transmission; virus was also detected after IT inoculation. No virus was detected after IG inoculation.
References: doi: 10.1101/2020.03.13.990036; Preprint
Contact Info: Deng W, et al.; correspondence to Chuan Qin ([email protected])
URL: https://www.biorxiv.org/content/10.1101/2020.03.13.990036v2.full
Coronavirus Investigated: MERS-CoV
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: NIAID
Keywords: MERS-CoV, animal model, antiviral, remdesivir, therapy.
Summary of Study: The efficacy of prophylactic and therapeutic remdesivir treatment was tested in a rhesus macaque model of MERS-CoV infection. Prophylactic remdesivir treatment completely prevented MERS-CoV-induced clinical disease; therapeutic remdesivir treatment also provided a clear clinical benefit. The data support testing the efficacy of remdesivir treatment in the context of a MERS clinical trial.
References: doi: 10.1073/pnas.1922083117; PMID: 32054787
Contact Info: de Wit E, et al.; Correspondence to Emmie de Wit ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32054787/
NHP Species: rhesus macaques
Year Published: 2020
Study Type/Review:
NPRC/Institute: NIAID
Keywords: MERS-CoV, animal model, antiviral, remdesivir, therapy.
Summary of Study: The efficacy of prophylactic and therapeutic remdesivir treatment was tested in a rhesus macaque model of MERS-CoV infection. Prophylactic remdesivir treatment completely prevented MERS-CoV-induced clinical disease; therapeutic remdesivir treatment also provided a clear clinical benefit. The data support testing the efficacy of remdesivir treatment in the context of a MERS clinical trial.
References: doi: 10.1073/pnas.1922083117; PMID: 32054787
Contact Info: de Wit E, et al.; Correspondence to Emmie de Wit ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32054787/
Coronavirus Investigated: SARS-CoV-2
NHP Species: multiple species
Year Published: 2020
Study Type/Review:
NPRC/Institute: Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China
Keywords: coronavirus, SARS-CoV-2, ACE2
Summary of Study: Authors conducted sequence and structural analyses of angiotensin-converting enzyme 2 (ACE2) from different species, which sheds some light on cross-species receptor usage of 2019-nCoV.
References: doi: 10.1016/j.jinf.2020.02.013
Contact Info: Li R, et al.; correspondence to Gaiping Zhang ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32092392/
NHP Species: multiple species
Year Published: 2020
Study Type/Review:
NPRC/Institute: Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China
Keywords: coronavirus, SARS-CoV-2, ACE2
Summary of Study: Authors conducted sequence and structural analyses of angiotensin-converting enzyme 2 (ACE2) from different species, which sheds some light on cross-species receptor usage of 2019-nCoV.
References: doi: 10.1016/j.jinf.2020.02.013
Contact Info: Li R, et al.; correspondence to Gaiping Zhang ([email protected])
URL: https://pubmed.ncbi.nlm.nih.gov/32092392/