Precision Disease Modeling

ORIP has funded Pilot Centers for Precision Disease Modeling. Each Center consists of an interdisciplinary research team of scientists and physicians organized to address specific medical problems by creating new animal models to more precisely mimic patient-specific disease processes and to develop innovative treatment options. Current technology permits specific genetic modifications in model animal species, as well as the ability to replace specific cells and tissues, resulting in phenotypes that are closely analogous to human patients. These new animal models will accelerate the generation of precision diagnostic and therapeutic approaches for such diseases as cancer, Parkinson’s disease, and diabetes.

A New Disease Platform Leveraging Complex Drosophila and Mammalian Models
Ross L. Cagan, Ph.D.
Center for Personalized Cancer Therapeutics
The Mount Sinai Hospital, New York, NY
Mount Sinai Pilot Center for Precision Disease Modeling

The Jackson Laboratory Center for Precision Genetics: From New Models to Novel Therapeutics
Robert W. Burgess, Ph.D.
The Jackson Laboratory, Bar Harbor, ME
JAX Center for Precision Genetics

MSKCC Pilot Center for Precision Disease Modeling
Scott W. Lowe, Ph.D.
Memorial Sloan-Kettering Cancer Center, New York, NY
Pilot Center for Precision Disease Modeling