Welcome to ORIP

In recent years, the research community has become increasingly interested in precision disease modeling, and it remains at the forefront of personalized medicine approaches for developing models for human disease. In 2014, ORIP launched the Precision Disease Modeling Initiative (PAR-14-280) and subsequently funded three Pilot Centers for Disease Modeling (U54) in 2015.

The Oklahoma Medical Research Foundation has been working toward a more inclusive, collaborative future by supporting research and training focused on health of Tribal Nations and other underrepresented minorities with community-centric and forward-thinking scientific initiatives.

ORIP has reissued S10 notices of funding opportunities (NOFOs) as PAR-24-264, PAR-24-265, and PAR 24-326. These NOFOs support the purchase of state-of-the-art, commercially available instruments to be shared by NIH-funded investigators.

This notice of funding opportunity invites U54 cooperative agreement applications for the support and advancement of the Centers for Precision Disease Modeling. The goal of the Centers is to support collaborative research projects that bridge current personalized medicine efforts in human subjects with advances in animal genomics and genetic manipulation technologies.

Dr. Tammie Benzinger is uncovering the mysteries of Alzheimer’s disease using ORIP-supported resources. Her work recently led to FDA approval of a new drug designed to clear amyloid plaques in early symptomatic Alzheimer’s disease.

The Macaque Genotype and Phenotype (mGAP) resource provides genome-wide variant data from thousands of rhesus macaques, enabling access to, and comparison of, macaque genotype data across major captive populations, including the National Primate Research Centers.

ORIP has issued a funding opportunity, PAR-25-061, to invite applications from eligible institutions to modernize existing or construct new biomedical research facilities. Applications from both research-intensive institutions and Institutions of Emerging Excellence in biomedical research from all geographic regions in the nation are strongly encouraged.

Dr. Hugo Bellen is an ORIP-funded researcher who uses the fruit fly (Drosophila melanogaster) as a model for neurological diseases. Dr. Bellen was recently recognized as the recipient of the 2024 Gruber Genetics Prize.

ORIP participates in two federal Small Business grant programs—the Small Business Innovation Research (SBIR) and the Small Business Technology Transfer (STTR)—that provide seed funding to small businesses to develop technologies that have potential for commercialization.