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Supporting technologies to advance research discoveries

Small Business Toolbox

New to the Small Business Program? Where to Start?

SBIR/STTR Programs

ORIP seeks to increase small business participation in federally supported research and development as well as the private-sector commercialization of technology developed with federal support. The office achieves this through the federal government's Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs.

For those seeking more information about ORIP's SBIR/STTR programs, view the related fact sheet.

SBIR (R43/R44) grants support domestic small businesses engaging in research and development that has the potential for commercialization. Phase I, which uses the R43 funding mechanism, offers up to $306,872 for a project timeline between 6 months to 2 years. Phase II, which uses the R44 funding mechanism, offers up to $2,045,816 for a project timeline between 1 to 3 years. These award amounts and durations are guidelines that can be exceeded with appropriate justification. See SBIR funding opportunities.

STTR (R41/R42) grants also support innovative research that results in commercial products or services that benefit the public. Funding applicants must have a formal research partnerships with universities or other nonprofit research institutions. Phase I, which uses the R41 funding mechanism, typically offers up to $306,872 for a project timeline between 6 months to 2 years. Phase II, which uses the R42 mechanism, offers up to $2,045,816 for a project timeline between 1 to 3 years. These award amounts and durations are guidelines that can be exceeded with appropriate justification. See STTR funding opportunities.

The SBIR and STTR programs have three application cycles each year. Application deadlines for these periods are January 5, April 5, and September 5.

There are significant differences between the SBIR and STTR programs. For detailed information, see the program descriptions on the NIH Small Business Funding Opportunities website.

Tips to Create a Small Business Company

This material is for informational purposes only.

NIH Small Business Grant Support: Overview

This material is for informational purposes only.

 

SBIR/STTR Technical Assistance Programs

To help small businesses with SBIR/STTR funding move their products into the marketplace, NIH offers the following programs providing technical and commercialization assistance:

Technical and Business Assistance (TABA) Needs Assessment

Technical and Business Assistance (TABA) Consulting Services

For More Information

Grants Process Overview and SBIR/STTR Application Process Infographic

What are SBIR and STTR Programs?

Electronic Submission Process for Grants

NIH Success Stories (supported by ORIP)

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What do arthritis, osteoporosis, and some cancers have in common? They all show signs of tissue damage early on in their disease progression. But researchers and clinicians don’t have an easy way to detect this damage. If they did, diseases could be diagnosed earlier and more accurately.

Using Vibrations in Medical Devices

In engineering, an actuator turns a signal into mechanical action or motion. For example, actuators in your printer, in the form of electric motors, are what move the ink cartridge from side to side. Dr. Maureen L. Mulvihill, a materials scientist, earned her PhD researching piezoelectric materials...

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Combinati

Combinati believes simplicity shouldn’t require sacrificing robustness, quality or rigor – in fact, it should enable it. Our easy-to-use digital PCR platform offers absolute quantification to track disease-relevant biomarkers over time with high accuracy...

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