Small Business Toolbox
New to the Small Business Program? Where to Start?
SBIR/STTR Programs
ORIP seeks to increase small business participation in federally supported research and development as well as the private-sector commercialization of technology developed with federal support. The office achieves this through the federal government's Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs.
For those seeking more information about ORIP's SBIR/STTR programs, view the related fact sheet.
SBIR (R43/R44) grants support domestic small businesses engaging in research and development that has the potential for commercialization. Phase I, which uses the R43 funding mechanism, offers up to $306,872 for a project timeline between 6 months to 2 years. Phase II, which uses the R44 funding mechanism, offers up to $2,045,816 for a project timeline between 1 to 3 years. These award amounts and durations are guidelines that can be exceeded with appropriate justification. See SBIR funding opportunities.
STTR (R41/R42) grants also support innovative research that results in commercial products or services that benefit the public. Funding applicants must have a formal research partnerships with universities or other nonprofit research institutions. Phase I, which uses the R41 funding mechanism, typically offers up to $306,872 for a project timeline between 6 months to 2 years. Phase II, which uses the R42 mechanism, offers up to $2,045,816 for a project timeline between 1 to 3 years. These award amounts and durations are guidelines that can be exceeded with appropriate justification. See STTR funding opportunities.
The SBIR and STTR programs have three application cycles each year. Application deadlines for these periods are January 5, April 5, and September 5.
There are significant differences between the SBIR and STTR programs. For detailed information, see the program descriptions on the NIH Small Business Funding Opportunities website.
Tips to Create a Small Business Company
This material is for informational purposes only.
NIH Small Business Grant Support: Overview
This material is for informational purposes only.
SBIR/STTR Technical Assistance Programs
To help small businesses with SBIR/STTR funding move their products into the marketplace, NIH offers the following programs providing technical and commercialization assistance:
Technical and Business Assistance (TABA) Needs Assessment
Technical and Business Assistance (TABA) Consulting Services
For More Information
Grants Process Overview and SBIR/STTR Application Process Infographic
What are SBIR and STTR Programs?
Electronic Submission Process for Grants
NIH Success Stories (supported by ORIP)
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Using Vibrations in Medical Devices
In engineering, an actuator turns a signal into mechanical action or motion. For example, actuators in your printer, in the form of electric motors, are what move the ink cartridge from side to side. Dr. Maureen L. Mulvihill, a materials scientist, earned her PhD researching piezoelectric materials...
![](/sites/default/files/inline-images/Frame%20340.png)
Utah Company Develops Research Tool to Detect Diseases Earlier and More Accurately
What do arthritis, osteoporosis, and some cancers have in common? They all show signs of tissue damage early on in their disease progression. But researchers and clinicians don’t have an easy way to detect this damage. If they did, diseases could be diagnosed earlier and more accurately.
NIH Portfolio Company Showcase (supported by ORIP)
![3Helix logo](/sites/default/files/inline-images/3Helix.png)
3Helix commercializes labeled collagen hybridizing peptide (CHP) that specifically binds to such unfolded collagen chains, enabling unlimited laboratory applications in pathology, biomechanics, cell biology, regenerative medicine, and more.
![Actuated Medical: Innovative motion, positive outcomes (logo)](/sites/default/files/inline-images/Actuated_Med_logo.png)
The future looks brighter for 100M Americans living with neurological conditions and musculoskeletal disorders (e.g., Parkinson’s, stroke, urinary incontinence). These conditions significantly reduce patients’ quality of life and cost the healthcare system an estimated $800B annually.
![Combinati logo](/sites/default/files/inline-images/combinati.png)
Combinati believes simplicity shouldn’t require sacrificing robustness, quality or rigor – in fact, it should enable it. Our easy-to-use digital PCR platform offers absolute quantification to track disease-relevant biomarkers over time with high accuracy and precision.
![CryoCrate, life in nano ice (logo)](/sites/default/files/inline-images/CryoCrate_logo.png)
Cryopreservation is a critical platform technology for biomedical research and clinical applications. There are numerous cell and tissue types that (a) cannot be cryopreserved or (b) can be cryopreserved, but lose viability during the freeze-thaw process.
![Sarcomatrix logo](/sites/default/files/inline-images/Sarcomatrix_logo.png)
Sarcomatrix Therapeutics Corp. is a pioneering biopharmaceutical company dedicated to advancing novel therapeutics that leverage deep insights into muscle biology and tissue regeneration to address muscle-wasting diseases with high unmet needs.