A novel exoskeleton purchased with support from ORIP’s S10 Basic Instrumentation Grant (BIG) Program (S10OD032226) has changed the landscape of mobility research and rehabilitation in the United States. The BIG Program provides funding for investigators at institutions that have not received substantial S10 instrumentation funding to purchase a single specialized, commercially available instrument.

In October 2012, Superstorm Sandy hit the U.S. East Coast, causing devastation across the New York metropolitan area (Figure 1). Extensive water damage and power outages occurred throughout NYU Langone Health’s Manhattan main campus, affecting multiple research and clinical facilities and necessitating emergency patient evacuations.

Grant Number: R24OD030215 

Research Emphasis/Objectives

The main goal of this R24 project is to develop monoclonal antibodies (mAbs) that can be used in immunological assays for the identification and quantification of 10 biomarkers of inflammation and metabolism in the New World monkey (NWM) species marmoset (MAR, Callithrix jacchus), owl monkey (OLM, Aotus sp.), and squirrel monkey (SQM, Saimiri sp.).

Current Research

The general approach is to produce the recombinant MAR versions of the adiponectin, CD69, C-reactive protein (CRP), insulin, IL-4, IL-6, IL-10, IP-10 (CXCL10), granzyme B, and leptin biomarkers; immunize mice with these purified proteins; identify reactive mAbs and optimal antibody pairs; test antibodies for reactivity with biological samples obtained from MAR, OLM, and SQM; and develop immunoassays.

Services Provided

Samples of mAbs developed within the project, protocols, and reactivity tables will be made available for U.S. researchers. Currently, validated capture and detection antibodies have been identified for adiponectin, CRP, IL-4, IL-6, IL-10, IP-10 (CXCL10), and granzyme B. 

Contact Information

Department of Biology
D.R. Semmes School of Science
Trinity University
One Trinity Place
San Antonio, TX 782212
www.trinity.edu/sites/nwmimmunoreagents

Principal Investigator/Center Director

Luis D. Giavedoni, Ph.D.
Phone: 210-999-7245
[email protected]

Additional Contact

Jessica Callery, Resource Manager
Phone: 210-999-7243
[email protected]

Dr. Kieran Koch-Laskowski, currently enrolled in the Combined D.V.M.–Ph.D. Program at Cornell University’s College of Veterinary Medicine, has had aspirations of pursuing veterinary school since childhood. Her innate love of animals and desire to help them steered her toward an undergraduate program at the University of Pennsylvania to earn a B.A. in the biological basis of behavior (neuroscience).