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Sunitinib Inhibits STAT3 Phosphorylation in Cardiac Muscle and Prevents Cardiomyopathy in the mdx Mouse Model of Duchenne Muscular Dystrophy

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Duchenne muscular dystrophy (DMD) is the most common form of muscular dystrophy, affecting about 1 in 5,000 boys worldwide. DMD is a fatal X-linked genetic disorder that results from mutations in the dystrophin gene and leads to progressive muscular degeneration. Individuals with DMD often die at a young age from respiratory or heart failure. To date, few studies have examined the basis of cardiac failure associated with DMD, and no effective U.S. Food and Drug Administration (FDA)–approved treatment options are available.

ORIP Support for Small Businesses Leads to New Commercial Technology Outcomes That Benefit Community Resources and Advance Research Discoveries

ORIP participates in two federal grant programs that provide funding to small businesses: the Small Business Innovation Research (SBIR) program and the Small Business Technology Transfer (STTR) program. The primary goal of ORIP’s small business programs is to attract innovative SBIR/STTR projects that could benefit research resources and communities associated with ORIP’s mission.

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