Super-Resolution Imaging: Beating the Boundaries of Light
Substance use disorders and neuropsychiatric conditions are brain diseases characterized by morphological and functional adaptations in neurons and neural circuits. Traditionally, neuroscientists use conventional confocal or electron microscopy to characterize how abused substances remodel sites of synaptic communication. However, confocal microscopy is hindered by diffraction limits of light waves and cannot resolve structures below a spatial resolution of about 250 nm.