Coronavirus Studies in Nonhuman Primate Models
This page provides a curated list of coronavirus studies and reviews using nonhuman primate (NHP) models.
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Washington National Primate Research Center; North Carolina State University College of Veterinary Medicine; University of Washington.
Keywords: SARS-CoV-2, single cell immune repertoire profiling, gene expression, primates
Summary of Study: Results establish the ability to perform high throughput scIRS analysis in rhesus macaques with comparable performances to commercially available platforms.
References: doi: 10.1101/2021.08.17.456682
Contact Info: Xinxia Peng: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.08.17.456682v1.supplementary-mater…
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Washington National Primate Research Center; North Carolina State University College of Veterinary Medicine; University of Washington.
Keywords: SARS-CoV-2, single cell immune repertoire profiling, gene expression, primates
Summary of Study: Results establish the ability to perform high throughput scIRS analysis in rhesus macaques with comparable performances to commercially available platforms.
References: doi: 10.1101/2021.08.17.456682
Contact Info: Xinxia Peng: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.08.17.456682v1.supplementary-mater…
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; Henan Normal University; Guangzhou Medical University; Fudan University
Keywords: SARS-CoV-2, inflammation, lung pathology, immune response, primates
Summary of Study: SARS-CoV-2 triggers an immediate mast cell (MC) degranulation, which initiates the alveolar epithelial inflammation and disrupts the tight junction. MC stabilizers that block degranulation reduce virus-induced lung inflammation and injury.
References: doi: 10.1101/2021.06.24.449680
Contact Info: Jian-Hua Wang: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.06.24.449680v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Chinese Academy of Sciences; Henan Normal University; Guangzhou Medical University; Fudan University
Keywords: SARS-CoV-2, inflammation, lung pathology, immune response, primates
Summary of Study: SARS-CoV-2 triggers an immediate mast cell (MC) degranulation, which initiates the alveolar epithelial inflammation and disrupts the tight junction. MC stabilizers that block degranulation reduce virus-induced lung inflammation and injury.
References: doi: 10.1101/2021.06.24.449680
Contact Info: Jian-Hua Wang: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.06.24.449680v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: University of Liverpool, Public Health England, University of Bristol, and others
Keywords: SARS-CoV-2, the leader-transcriptional regulatory sequence gene junction, high resolution sequencing, primates
Summary of Study: LeTRS, a bioinformatics tool, identified known leader-TRS-junctions and identified novel species that were common across different species. The data indicated multi-phasic abundance of sgmRNAs in two different NHP models, with spikes in sgmRNA abundance reflected in human samples, and therefore has implications for transmission models and nucleic acid-based diagnostics.
References: doi: 10.1101/2021.03.03.433753
Contact Info: Julian Hiscox: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.03.03.433753v2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: University of Liverpool, Public Health England, University of Bristol, and others
Keywords: SARS-CoV-2, the leader-transcriptional regulatory sequence gene junction, high resolution sequencing, primates
Summary of Study: LeTRS, a bioinformatics tool, identified known leader-TRS-junctions and identified novel species that were common across different species. The data indicated multi-phasic abundance of sgmRNAs in two different NHP models, with spikes in sgmRNA abundance reflected in human samples, and therefore has implications for transmission models and nucleic acid-based diagnostics.
References: doi: 10.1101/2021.03.03.433753
Contact Info: Julian Hiscox: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.03.03.433753v2
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: SL VaxiGen Inc., Genexine Inc., Sorea Bio Park, Scongnam, Republic of Korea
Keywords: SARS-CoV-2, DNA-based vaccine candidate, GX-19, immunization, primates
Summary of Study: Vaccination with vaccine candidate GX-19 elicits a concurrent humoral response and Th1-biased immune responses in both mice and non-human primate models. In NHPs this response includes neutralizing antibodies that provide potent protective efficacy against SARS-CoV-2 infection.
References: doi: https://doi.org/10.1101/2020.10.09.334136
Contact Info: Young Chul Sung: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.10.09.334136v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: SL VaxiGen Inc., Genexine Inc., Sorea Bio Park, Scongnam, Republic of Korea
Keywords: SARS-CoV-2, DNA-based vaccine candidate, GX-19, immunization, primates
Summary of Study: Vaccination with vaccine candidate GX-19 elicits a concurrent humoral response and Th1-biased immune responses in both mice and non-human primate models. In NHPs this response includes neutralizing antibodies that provide potent protective efficacy against SARS-CoV-2 infection.
References: doi: https://doi.org/10.1101/2020.10.09.334136
Contact Info: Young Chul Sung: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.10.09.334136v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID, Emory University, Moderna
Keywords: SARS-CoV-2, mRNA vaccine, immune response, pathology, primates
Summary of Study: Immunization with two doses of mRNA-1273 achieves effective immunity that rapidly controls lower and upper airway viral replication against the B.1.351 variant in NHP.
References: doi: 10.1101/2021.05.21.445189
Contact Info: Barney Graham: [email protected]; Robert Seder: [email protected];
URL: https://www.biorxiv.org/content/10.1101/2021.05.21.445189v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID, Emory University, Moderna
Keywords: SARS-CoV-2, mRNA vaccine, immune response, pathology, primates
Summary of Study: Immunization with two doses of mRNA-1273 achieves effective immunity that rapidly controls lower and upper airway viral replication against the B.1.351 variant in NHP.
References: doi: 10.1101/2021.05.21.445189
Contact Info: Barney Graham: [email protected]; Robert Seder: [email protected];
URL: https://www.biorxiv.org/content/10.1101/2021.05.21.445189v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center; Washington University SOM; TX Biomedical Research Institute; Tulane University
Keywords: SARS-CoV-2, bronchoalveolar lavage, transcription profiling, immune response, primates
Summary of Study: The recruitment of a myeloid-cell-mediated Type I IFN response is associated with the rapid clearance of SARS-CoV-2 infection in macaques.
References: PMID: 34282414 / doi: 10.21203/rs.3.rs-664507/v1
Contact Info: Dhiraj Singh: [email protected]
URL: https://www.researchsquare.com/article/rs-664507/v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Southwest National Primate Research Center; Washington University SOM; TX Biomedical Research Institute; Tulane University
Keywords: SARS-CoV-2, bronchoalveolar lavage, transcription profiling, immune response, primates
Summary of Study: The recruitment of a myeloid-cell-mediated Type I IFN response is associated with the rapid clearance of SARS-CoV-2 infection in macaques.
References: PMID: 34282414 / doi: 10.21203/rs.3.rs-664507/v1
Contact Info: Dhiraj Singh: [email protected]
URL: https://www.researchsquare.com/article/rs-664507/v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Vyriad Inc.; Imanis Life Sciences; Mayo Clinic; Regeneron Pharmaceuticals, Inc.; University of Minnesota
Keywords: SARS-CoV-2, oral rhabdoviral vaccine, boost, immune response, primates
Summary of Study: A relevant translational NHP model was used to demonstrate the safety and oral immunogenicity of a VSV-derived mucosal vaccine for SARS-CoV-2. Pre-IND discussion with FDA are ongoing.
References: doi: 10.1101/2021.10.16.464660
Contact Info: Stephen Russell: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.10.16.464660v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Vyriad Inc.; Imanis Life Sciences; Mayo Clinic; Regeneron Pharmaceuticals, Inc.; University of Minnesota
Keywords: SARS-CoV-2, oral rhabdoviral vaccine, boost, immune response, primates
Summary of Study: A relevant translational NHP model was used to demonstrate the safety and oral immunogenicity of a VSV-derived mucosal vaccine for SARS-CoV-2. Pre-IND discussion with FDA are ongoing.
References: doi: 10.1101/2021.10.16.464660
Contact Info: Stephen Russell: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.10.16.464660v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, pigtail macaques
Year Published:
Study Type/Review:
NPRC/Institute: National Institute of Animal Biotechnology, Telangana, India
Keywords: SARS-CoV-2, ACE2 receptor of various species, several species.
Summary of Study: The interaction of SARS-CoV-2 spike receptor-binding domain with its receptor (ACE2) in different hosts was evaluated to understand and predict viral entry. Most of the species considered in this study showed high probability of viral entry and should be followed to determine their ability to act as carriers and/or disseminators.
References: doi: https://doi.org/10.1101/2020.05.08.084327
Contact Info: Ravi Kumar Gandham: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.05.08.084327v4
NHP Species: rhesus macaques, pigtail macaques
Year Published:
Study Type/Review:
NPRC/Institute: National Institute of Animal Biotechnology, Telangana, India
Keywords: SARS-CoV-2, ACE2 receptor of various species, several species.
Summary of Study: The interaction of SARS-CoV-2 spike receptor-binding domain with its receptor (ACE2) in different hosts was evaluated to understand and predict viral entry. Most of the species considered in this study showed high probability of viral entry and should be followed to determine their ability to act as carriers and/or disseminators.
References: doi: https://doi.org/10.1101/2020.05.08.084327
Contact Info: Ravi Kumar Gandham: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.05.08.084327v4
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: University of Hawaii, Bioqual, Inc., Soligenix, Inc.
Keywords: SARS-CoV-2, recombinant subunit protein vaccine, spike protein, immune response, pathology, primates
Summary of Study: A recombinant subunit protein formulated with CoVaccine HT adjuvant induces superior immunity than natural infection and reduces viral load while protecting cynomolgus macaques from COVID-19-like disease caused by late SARS-CoV-2 P.1 (Gamma) challenge.
References: doi: 10.1101/2021.09.24.461759
Contact Info: Axel Lehrer: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.09.24.461759v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: University of Hawaii, Bioqual, Inc., Soligenix, Inc.
Keywords: SARS-CoV-2, recombinant subunit protein vaccine, spike protein, immune response, pathology, primates
Summary of Study: A recombinant subunit protein formulated with CoVaccine HT adjuvant induces superior immunity than natural infection and reduces viral load while protecting cynomolgus macaques from COVID-19-like disease caused by late SARS-CoV-2 P.1 (Gamma) challenge.
References: doi: 10.1101/2021.09.24.461759
Contact Info: Axel Lehrer: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.09.24.461759v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: Duke University School of Medicine
Keywords: SARS-CoV-2, neutralizing and infection-enhancing antibodies, mice and primates
Summary of Study: SARS-CoV-2 antibodies can mediate infection enhancement in vitro. However, this in vitro phenotype does not translate to enhanced infection in a non-human primate model of SARS-CoV-2 infection. These preclinical results indicate that SARS-CoV-2 antibody treatments or the induction of SARS-CoV-2 antibodies by vaccination have a low likelihood of exacerbating COVID-19 disease in humans.
References: doi: https://doi.org/10.1101/2020.12.31.424729
Contact Info: Barton Haynes: [email protected]/Kevin Saunders: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.12.31.424729v2
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: Duke University School of Medicine
Keywords: SARS-CoV-2, neutralizing and infection-enhancing antibodies, mice and primates
Summary of Study: SARS-CoV-2 antibodies can mediate infection enhancement in vitro. However, this in vitro phenotype does not translate to enhanced infection in a non-human primate model of SARS-CoV-2 infection. These preclinical results indicate that SARS-CoV-2 antibody treatments or the induction of SARS-CoV-2 antibodies by vaccination have a low likelihood of exacerbating COVID-19 disease in humans.
References: doi: https://doi.org/10.1101/2020.12.31.424729
Contact Info: Barton Haynes: [email protected]/Kevin Saunders: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.12.31.424729v2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: CureVac AG Tuebingen, Germany
Keywords: SARS-CoV-2, mRNA vaccine CVnCoV, safety, immunogenicity, and protective efficacy, primates
Summary of Study: The efficacy of CVnCoV, a lipid-nanoparticle encapsulated, sequence optimized mRNA-based SARS-CoV-2 vaccine was evaluated. The study demonstrates that CVnCoV induces robust humoral and cellular responses in non-human primates. These results demonstrate safety, immunogenicity, and protective efficacy of this vaccine that extend beyond previously published preclinical data and provide strong support for further clinical testing in ongoing phase 2b/3 efficacy studies.
References: doi: https://doi.org/10.1101/2020.12.23.424138
Contact Info: no contact information provided
URL: https://www.biorxiv.org/content/10.1101/2020.12.23.424138v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: CureVac AG Tuebingen, Germany
Keywords: SARS-CoV-2, mRNA vaccine CVnCoV, safety, immunogenicity, and protective efficacy, primates
Summary of Study: The efficacy of CVnCoV, a lipid-nanoparticle encapsulated, sequence optimized mRNA-based SARS-CoV-2 vaccine was evaluated. The study demonstrates that CVnCoV induces robust humoral and cellular responses in non-human primates. These results demonstrate safety, immunogenicity, and protective efficacy of this vaccine that extend beyond previously published preclinical data and provide strong support for further clinical testing in ongoing phase 2b/3 efficacy studies.
References: doi: https://doi.org/10.1101/2020.12.23.424138
Contact Info: no contact information provided
URL: https://www.biorxiv.org/content/10.1101/2020.12.23.424138v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys, rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Tulane NPRC
Keywords: SARS-CoV-2, immune response, primates
Summary of Study: Increased levels of monocytes and chemokines after infection is associated with viral load and disease severity
References: doi: https://doi.org/10.1101/2020.07.21.213777
Contact Info: Monica Vaccari, [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.07.21.213777v1%20
NHP Species: african green monkeys, rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Tulane NPRC
Keywords: SARS-CoV-2, immune response, primates
Summary of Study: Increased levels of monocytes and chemokines after infection is associated with viral load and disease severity
References: doi: https://doi.org/10.1101/2020.07.21.213777
Contact Info: Monica Vaccari, [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.07.21.213777v1%20
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Shanghai Jemincare Pharmaceuticals, Wuhan Institute of Virology, and others
Keywords: SARS-CoV-2, antivirus antibodies, prophylactic and potent therapeutic efficacy, primates
Summary of Study: Antibody JMB2002 demonstrated complete prophylactic and potent therapeutic efficacy in a rhesus macaque disease model.
References: doi: 10.1101/2021.02.07.429299
Contact Info: Wuxiang Guan: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.02.07.429299v2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Shanghai Jemincare Pharmaceuticals, Wuhan Institute of Virology, and others
Keywords: SARS-CoV-2, antivirus antibodies, prophylactic and potent therapeutic efficacy, primates
Summary of Study: Antibody JMB2002 demonstrated complete prophylactic and potent therapeutic efficacy in a rhesus macaque disease model.
References: doi: 10.1101/2021.02.07.429299
Contact Info: Wuxiang Guan: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.02.07.429299v2
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: Inserm, CEA, Paris, France; University of Amsterdam; and others
Keywords: SARS-CoV-2, prophylactic and therapeutic effect of COVA1-18 in vivo, several species, primates
Summary of Study: COVA1-18, a neutralizing antibody isolated from a convalescent patient and highly potent against the B.1.1.7 isolate, had very strong antiviral activity in the upper respiratory compartments of cynomolgus macaques, with an estimated reduction in viral infectivity of more than 95%, and prevented lymphopenia and extensive lung lesions.
References: PMID: 33619476 / doi: 10.21203/rs.3.rs-235272/v1
Contact Info: Roger LeGrand: [email protected]; MJ Van Gils: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899470/pdf/nihpp-rs235272v1.pdf
NHP Species:
Year Published:
Study Type/Review:
NPRC/Institute: Inserm, CEA, Paris, France; University of Amsterdam; and others
Keywords: SARS-CoV-2, prophylactic and therapeutic effect of COVA1-18 in vivo, several species, primates
Summary of Study: COVA1-18, a neutralizing antibody isolated from a convalescent patient and highly potent against the B.1.1.7 isolate, had very strong antiviral activity in the upper respiratory compartments of cynomolgus macaques, with an estimated reduction in viral infectivity of more than 95%, and prevented lymphopenia and extensive lung lesions.
References: PMID: 33619476 / doi: 10.21203/rs.3.rs-235272/v1
Contact Info: Roger LeGrand: [email protected]; MJ Van Gils: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899470/pdf/nihpp-rs235272v1.pdf
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Novavax, Inc. 21 Firstfield Road, Gaithersburg, MD, 20878
Keywords: SARS-CoV-2, subunit vaccine, pulmonary disease, primates
Summary of Study: Cynomolgus macaques immunized with NVX-CoV2373 and the saponin-based Matrix-M adjuvant induced antibody that was neutralizing and blocked binding to the human angiotensin-converting enzyme 2 (hACE2) receptor. Following intranasal and intratracheal challenge with SARS-CoV-2, immunized macaques were protected against upper and lower infection and pulmonary disease.
References: doi: https://doi.org/10.1101/2020.08.18.256578
Contact Info: Gale Smith at [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.08.18.256578v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Novavax, Inc. 21 Firstfield Road, Gaithersburg, MD, 20878
Keywords: SARS-CoV-2, subunit vaccine, pulmonary disease, primates
Summary of Study: Cynomolgus macaques immunized with NVX-CoV2373 and the saponin-based Matrix-M adjuvant induced antibody that was neutralizing and blocked binding to the human angiotensin-converting enzyme 2 (hACE2) receptor. Following intranasal and intratracheal challenge with SARS-CoV-2, immunized macaques were protected against upper and lower infection and pulmonary disease.
References: doi: https://doi.org/10.1101/2020.08.18.256578
Contact Info: Gale Smith at [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.08.18.256578v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Yerkes NPRC, NIH, Ragon Institute, and others
Keywords: SARS-CoV-2, adjuvanted soluble protein vaccines, binding and functional neutralization assays and systems serology, primates
Summary of Study: Potent serum antibody responses are induced by soluble S trimers formulated with the oil-in-water emulsion adjuvant AS03, which conferred protection in the upper and lower airways of rhesus macaques following SARS-CoV-2 challenge.
References: PMID: 33688652 / doi: 10.1101/2021.03.02.433390
Contact Info: Robert Seder: [email protected]
URL: https://pubmed.ncbi.nlm.nih.gov/33688652/
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Yerkes NPRC, NIH, Ragon Institute, and others
Keywords: SARS-CoV-2, adjuvanted soluble protein vaccines, binding and functional neutralization assays and systems serology, primates
Summary of Study: Potent serum antibody responses are induced by soluble S trimers formulated with the oil-in-water emulsion adjuvant AS03, which conferred protection in the upper and lower airways of rhesus macaques following SARS-CoV-2 challenge.
References: PMID: 33688652 / doi: 10.1101/2021.03.02.433390
Contact Info: Robert Seder: [email protected]
URL: https://pubmed.ncbi.nlm.nih.gov/33688652/
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Eli Lilly & Co.; NIAID
Keywords: SARS-CoV-2, anti-spike neutralizing antibodies, primate challenge model
Summary of Study: Prophylactic treatment with LY-CoV555 (a neutralizing antibody) resulted in significant decreases in viral load (gRNA) and viral replication (sgRNA) in the lower respiratory tract of rhesus macaques following SARS-CoV2 inoculation, based on determination in BAL and lung tissue.
References: doi:Â https://doi.org/10.1101/2020.09.30.318972
Contact Info: Bryan Jones: [email protected]; Ester Falconer: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.09.30.318972v3
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Eli Lilly & Co.; NIAID
Keywords: SARS-CoV-2, anti-spike neutralizing antibodies, primate challenge model
Summary of Study: Prophylactic treatment with LY-CoV555 (a neutralizing antibody) resulted in significant decreases in viral load (gRNA) and viral replication (sgRNA) in the lower respiratory tract of rhesus macaques following SARS-CoV2 inoculation, based on determination in BAL and lung tissue.
References: doi:Â https://doi.org/10.1101/2020.09.30.318972
Contact Info: Bryan Jones: [email protected]; Ester Falconer: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.09.30.318972v3
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: NIAID/NIH
Keywords: SARS-CoV-2, virus variants, pathogenicity, immune response, primates
Summary of Study: A side-by-side comparison of three SARS-CoV-2 variants suggests that ongoing circulation under diverse evolutionary pressures favors transmissibility and immune evasion rather than an increase in intrinsic pathogenicity.
References: PMID: 34382034 / doi: 10.1101/2021.05.07.443115
Contact Info: Emmie de Wit: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.05.07.443115v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: NIAID/NIH
Keywords: SARS-CoV-2, virus variants, pathogenicity, immune response, primates
Summary of Study: A side-by-side comparison of three SARS-CoV-2 variants suggests that ongoing circulation under diverse evolutionary pressures favors transmissibility and immune evasion rather than an increase in intrinsic pathogenicity.
References: PMID: 34382034 / doi: 10.1101/2021.05.07.443115
Contact Info: Emmie de Wit: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.05.07.443115v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: marmosets, howler monkeys
Year Published:
Study Type/Review:
NPRC/Institute: Instituto Federal do Norte de Minas Gerais, Brazil; Universidade de Brasilia; State University of Santa Cruz, and others
Keywords: SARS-CoV-2, wild animals, epidemiology, neotropical primates
Summary of Study: 51 neotropical NHPs were examined for serological and virological evidence of SARS-CoV-2 infections. No evidence of viral spillover into these populations was found.
References: doi: 10.1101/2021.06.17.448890
Contact Info: Danilo Bretas deOliveira: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.06.17.448890v1
NHP Species: marmosets, howler monkeys
Year Published:
Study Type/Review:
NPRC/Institute: Instituto Federal do Norte de Minas Gerais, Brazil; Universidade de Brasilia; State University of Santa Cruz, and others
Keywords: SARS-CoV-2, wild animals, epidemiology, neotropical primates
Summary of Study: 51 neotropical NHPs were examined for serological and virological evidence of SARS-CoV-2 infections. No evidence of viral spillover into these populations was found.
References: doi: 10.1101/2021.06.17.448890
Contact Info: Danilo Bretas deOliveira: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.06.17.448890v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published:
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center, Tulane University School of Medicine
Keywords: SARS-CoV-2, viral RNA, evolution, genomic variants, primates
Summary of Study: Study confirmed importance of an intact furin cleavage site for SARS-CoV-2 infection in vivo; a new SARS-CoV-2 strain exclusive to the African green monkey species was identified.
References: doi: 10.1101/2021.08.22.457295
Contact Info: Nicolas Maness: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.08.22.457295v1.full
NHP Species: african green monkeys
Year Published:
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center, Tulane University School of Medicine
Keywords: SARS-CoV-2, viral RNA, evolution, genomic variants, primates
Summary of Study: Study confirmed importance of an intact furin cleavage site for SARS-CoV-2 infection in vivo; a new SARS-CoV-2 strain exclusive to the African green monkey species was identified.
References: doi: 10.1101/2021.08.22.457295
Contact Info: Nicolas Maness: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.08.22.457295v1.full
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: ONPRC/YNPRC
Keywords: SARS-CoV-2, kinase inhibitor, primates
Summary of Study: Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques
References: doi: https://doi.org/10.1101/2020.09.16.300277
Contact Info: Dr. Mirko Paiardini; E-mail address: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.09.16.300277v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: ONPRC/YNPRC
Keywords: SARS-CoV-2, kinase inhibitor, primates
Summary of Study: Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques
References: doi: https://doi.org/10.1101/2020.09.16.300277
Contact Info: Dr. Mirko Paiardini; E-mail address: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.09.16.300277v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: University of Liverpool; NIHR Health Protection Unit in Emerging and Zoonotic Infections; University of Bristol; IK Health Security Agency; Mahidol University; Alder Hey Children's Hospital; Imperial College London; The Roslin Institute, University of Edinburgh; Royal United Hospitals Bath NHS Foundation Trust; University of Oxford; A*STAR, Singapore.
Keywords: SARS-CoV-2, viral genomic variants, variant prediction, primates
Summary of Study: The selection pressure at two positions (the P323L and the D614G substitutions in the in NSP12 and the spike protein, respectively) was evaluated in two non-human primate models. The data in this study indicates that in some cases it may be possible to predict the emergence of a new dominant viral genome sequence and hence a new variant.
References: doi: 10.1101/2021.12.23.474030
Contact Info: Julian Hiscox: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.12.23.474030v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: University of Liverpool; NIHR Health Protection Unit in Emerging and Zoonotic Infections; University of Bristol; IK Health Security Agency; Mahidol University; Alder Hey Children's Hospital; Imperial College London; The Roslin Institute, University of Edinburgh; Royal United Hospitals Bath NHS Foundation Trust; University of Oxford; A*STAR, Singapore.
Keywords: SARS-CoV-2, viral genomic variants, variant prediction, primates
Summary of Study: The selection pressure at two positions (the P323L and the D614G substitutions in the in NSP12 and the spike protein, respectively) was evaluated in two non-human primate models. The data in this study indicates that in some cases it may be possible to predict the emergence of a new dominant viral genome sequence and hence a new variant.
References: doi: 10.1101/2021.12.23.474030
Contact Info: Julian Hiscox: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.12.23.474030v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: California Institute of Technology; NIAID, Fred Hutchinson Cancer Research Center; Bioqual; University of Oxford; Howard Hughes Medical Institute
Keywords: SARS-CoV-2, spike receptor-binding domains, mosaic nanoparticles, immunogenicity, mice, primates
Summary of Study: A mosaic RBD nanoparticle presenting 8 different sarbecovirus RBDs protected against challenges from both matched and mismatched sarbecoviruses, as compared with homotypic SARS-2 RBD nanoparticles that protected fully only against a matched challenge.
References: PMID: 35378752 / doi: 10.1101/2022.03.25.485875
Contact Info: Pamela Bjorkman: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.03.25.485875v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: California Institute of Technology; NIAID, Fred Hutchinson Cancer Research Center; Bioqual; University of Oxford; Howard Hughes Medical Institute
Keywords: SARS-CoV-2, spike receptor-binding domains, mosaic nanoparticles, immunogenicity, mice, primates
Summary of Study: A mosaic RBD nanoparticle presenting 8 different sarbecovirus RBDs protected against challenges from both matched and mismatched sarbecoviruses, as compared with homotypic SARS-2 RBD nanoparticles that protected fully only against a matched challenge.
References: PMID: 35378752 / doi: 10.1101/2022.03.25.485875
Contact Info: Pamela Bjorkman: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.03.25.485875v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID, Emory, OLAW,
Keywords: SARS-CoV-2, parainfluenza virus-vectored vaccine, pediatric, immune response, primates
Summary of Study: Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine candidate is protective in macaques
References: PMID: 35665011 PMCID: PMC9164439 DOI: 10.1101/2022.05.21.492923
Contact Info: Ursula J. Buchholz: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.05.21.492923v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: NIAID, Emory, OLAW,
Keywords: SARS-CoV-2, parainfluenza virus-vectored vaccine, pediatric, immune response, primates
Summary of Study: Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine candidate is protective in macaques
References: PMID: 35665011 PMCID: PMC9164439 DOI: 10.1101/2022.05.21.492923
Contact Info: Ursula J. Buchholz: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.05.21.492923v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Shanghai Jiao Tong University; Westlake University, China; University of Texas, medical Branch; Jecho Biopharmaceuticals Co.; China CDC; Zhengzhou University People's Hospital; Jecho Laboratories (Frederick, MD)
Keywords: SARS-CoV-2, monoclonal antibody, virus genomic variants, spike protein, mice, primates
Summary of Study: This report characterizes the therapeutic antibodies specific to the tip of spike against SARS-CoV-2 and suggests the potential of antibody treatment with 2G1 to bring clinical benefit to COVID-19 patients.
References: doi: 10.1101/2021.09.24.461616
Contact Info: Lei Han: [email protected]; Hua Jiang: [email protected]; Yueqing Xie: jecholabs.com; Qiang Zhou: [email protected]; Jianwei Zhu: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.09.24.461616v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Shanghai Jiao Tong University; Westlake University, China; University of Texas, medical Branch; Jecho Biopharmaceuticals Co.; China CDC; Zhengzhou University People's Hospital; Jecho Laboratories (Frederick, MD)
Keywords: SARS-CoV-2, monoclonal antibody, virus genomic variants, spike protein, mice, primates
Summary of Study: This report characterizes the therapeutic antibodies specific to the tip of spike against SARS-CoV-2 and suggests the potential of antibody treatment with 2G1 to bring clinical benefit to COVID-19 patients.
References: doi: 10.1101/2021.09.24.461616
Contact Info: Lei Han: [email protected]; Hua Jiang: [email protected]; Yueqing Xie: jecholabs.com; Qiang Zhou: [email protected]; Jianwei Zhu: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.09.24.461616v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: pigtail macaques
Year Published:
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Florida State University; University of Texas Medical Branch, Perelman School of Medicine; and others.
Keywords: SARS-CoV-2, respiratory viral challenge, immune response, pathology, primates
Summary of Study: SARS-CoV-2 infection of pigtail macaques recapitulates important features of COVID-19 and reveals new immune and viral dynamics and thus may serve as a useful animal model for studying pathogenesis and testing vaccines and therapeutics.
References: doi: 10.1101/2021.08.28.458047
Contact Info: Nicholas Maness: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.08.28.458047v1
NHP Species: pigtail macaques
Year Published:
Study Type/Review:
NPRC/Institute: Tulane National Primate Research Center; Tulane University School of Medicine; Florida State University; University of Texas Medical Branch, Perelman School of Medicine; and others.
Keywords: SARS-CoV-2, respiratory viral challenge, immune response, pathology, primates
Summary of Study: SARS-CoV-2 infection of pigtail macaques recapitulates important features of COVID-19 and reveals new immune and viral dynamics and thus may serve as a useful animal model for studying pathogenesis and testing vaccines and therapeutics.
References: doi: 10.1101/2021.08.28.458047
Contact Info: Nicholas Maness: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.08.28.458047v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre, The Netherlands; Amsterdam UMC; Utrecht University, and others
Keywords: SARS-CoV-2, brain inflammation, longitudinal positron emission tomography, neuropathology,primates
Summary of Study: SARS-CoV-2 causes brain inflammation and Lewy bodies, a hallmark for Parkinson, after an asymptomatic infection in macaques.
References: doi: 10.1101/2021.02.23.432474
Contact Info: Ingrid Philippens: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.02.23.432474v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre, The Netherlands; Amsterdam UMC; Utrecht University, and others
Keywords: SARS-CoV-2, brain inflammation, longitudinal positron emission tomography, neuropathology,primates
Summary of Study: SARS-CoV-2 causes brain inflammation and Lewy bodies, a hallmark for Parkinson, after an asymptomatic infection in macaques.
References: doi: 10.1101/2021.02.23.432474
Contact Info: Ingrid Philippens: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.02.23.432474v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: CureVac AG; Ragon Institute of MGH, MIT and Harvard; Harvard Medical School
Keywords: SARS-CoV-2, mRNA vaccine, immunogenicity and protective efficacy, immune response, primates
Summary of Study: Optimization of non-coding regions can greatly improve the immunogenicity and protective efficacy of a non-modified mRNA SARS-CoV-2 vaccine in macaques. Improved characteristics of CV2CoV, compared with CVnCoV, may translate into increased efficacy in humans, and clinical trials of CV2C0V are planned.
References: doi: 10.1038/s41586-021-04231-6
Contact Info: Susanne Rauch: [email protected]; Daniel Barouch: [email protected]
URL: https://www.nature.com/articles/s41586-021-04231-6
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: CureVac AG; Ragon Institute of MGH, MIT and Harvard; Harvard Medical School
Keywords: SARS-CoV-2, mRNA vaccine, immunogenicity and protective efficacy, immune response, primates
Summary of Study: Optimization of non-coding regions can greatly improve the immunogenicity and protective efficacy of a non-modified mRNA SARS-CoV-2 vaccine in macaques. Improved characteristics of CV2CoV, compared with CVnCoV, may translate into increased efficacy in humans, and clinical trials of CV2C0V are planned.
References: doi: 10.1038/s41586-021-04231-6
Contact Info: Susanne Rauch: [email protected]; Daniel Barouch: [email protected]
URL: https://www.nature.com/articles/s41586-021-04231-6
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre (BPRC), Rijswijk, The Netherlands
Keywords: SARS-CoV-2, post-acute phase, pulmonary disease, primates
Summary of Study: Study provides a detailed description of the pathogenesis of a low-passage SARS-CoV-2 isolate in two macaque species (rhesus and cynomolgus) and suggests both species represent an equally good model for COVID-19 prophylactic and therapeutic treatments.
References: doi: https://doi.org/10.1101/2020.11.05.369413
Contact Info: Ernst. J. Verschoor: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.11.05.369413v2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Biomedical Primate Research Centre (BPRC), Rijswijk, The Netherlands
Keywords: SARS-CoV-2, post-acute phase, pulmonary disease, primates
Summary of Study: Study provides a detailed description of the pathogenesis of a low-passage SARS-CoV-2 isolate in two macaque species (rhesus and cynomolgus) and suggests both species represent an equally good model for COVID-19 prophylactic and therapeutic treatments.
References: doi: https://doi.org/10.1101/2020.11.05.369413
Contact Info: Ernst. J. Verschoor: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.11.05.369413v2
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Tulane NPRC, Yerkes NPRC, New Iberia Research Center, Stanford
Keywords: SARS-CoV-2, subunit nanoparticle vaccine, primates
Summary of Study: These data reveal the promising performance of several adjuvants including AS03 and CpG 1018 (with Alum), which have been used in licensed vaccines, when used in conjunction with the SARS-CoV-2 RBD-NP immunogen.
References: PMID: 33594366 / doi: 10.1101/2021.02.10.430696
Contact Info: Bali Pulendran: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.02.10.430696v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Tulane NPRC, Yerkes NPRC, New Iberia Research Center, Stanford
Keywords: SARS-CoV-2, subunit nanoparticle vaccine, primates
Summary of Study: These data reveal the promising performance of several adjuvants including AS03 and CpG 1018 (with Alum), which have been used in licensed vaccines, when used in conjunction with the SARS-CoV-2 RBD-NP immunogen.
References: PMID: 33594366 / doi: 10.1101/2021.02.10.430696
Contact Info: Bali Pulendran: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.02.10.430696v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences
Keywords: SARS-CoV-2, interferon (IFN)-armed receptor-binding domain, immune response, primates
Summary of Study: The pan-epitope modified human I-R-F (I-P-R-F) vaccine provides rapid and complete protection throughout the upper and lower respiratory tracts against a high-dose SARS-CoV-2 challenge in rhesus macaques.
References: doi: 10.1038/s41422-021-00531-8
Contact Info: Hua Peng: https://www.nature.com/articles/s41422-021-00531-8/email/correspondent/c3/new
URL: https://www.nature.com/articles/s41422-021-00531-8
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Chinese Academy of Sciences
Keywords: SARS-CoV-2, interferon (IFN)-armed receptor-binding domain, immune response, primates
Summary of Study: The pan-epitope modified human I-R-F (I-P-R-F) vaccine provides rapid and complete protection throughout the upper and lower respiratory tracts against a high-dose SARS-CoV-2 challenge in rhesus macaques.
References: doi: 10.1038/s41422-021-00531-8
Contact Info: Hua Peng: https://www.nature.com/articles/s41422-021-00531-8/email/correspondent/c3/new
URL: https://www.nature.com/articles/s41422-021-00531-8
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Harvard Medical School
Keywords: SARS-CoV-2, Multiplexed proteomics and imaging, acute respiratory distress, primates
Summary of Study: The data in this paper highlight the ability of proteomics, imaging, and spatial transcriptomics of the same specimens to trace successive steps in diverse regulatory cascades. This approach is applicable to any fixed tissue. No other approach involving readily available histological specimens provides a similarly integrated picture of a disease process.
References: doi: https://doi.org/10.1101/2020.10.14.339952
Contact Info: Marian Kalocsay: [email protected]; Peter Sorger: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.10.14.339952v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Harvard Medical School
Keywords: SARS-CoV-2, Multiplexed proteomics and imaging, acute respiratory distress, primates
Summary of Study: The data in this paper highlight the ability of proteomics, imaging, and spatial transcriptomics of the same specimens to trace successive steps in diverse regulatory cascades. This approach is applicable to any fixed tissue. No other approach involving readily available histological specimens provides a similarly integrated picture of a disease process.
References: doi: https://doi.org/10.1101/2020.10.14.339952
Contact Info: Marian Kalocsay: [email protected]; Peter Sorger: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.10.14.339952v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: SWNPRC/BioNtech
Keywords: SARS-CoV-2, RNA vaccine, immune response, mice, primates
Summary of Study: This study challenged immunization with the BNT162b2 vaccine candidate containing mRNA encoding for the spike glycoprotein in mice and monkeys. Immunization in mice induced a strong immune response and immunization in monkeys fully protected the animal's lungs from SARS-CoV-2 infection.
References: doi: 10.1101/2020.09.08.280818
Contact Info: Ugur Sahin; Email: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.09.08.280818v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: SWNPRC/BioNtech
Keywords: SARS-CoV-2, RNA vaccine, immune response, mice, primates
Summary of Study: This study challenged immunization with the BNT162b2 vaccine candidate containing mRNA encoding for the spike glycoprotein in mice and monkeys. Immunization in mice induced a strong immune response and immunization in monkeys fully protected the animal's lungs from SARS-CoV-2 infection.
References: doi: 10.1101/2020.09.08.280818
Contact Info: Ugur Sahin; Email: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.09.08.280818v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Duke University School of Medicine; University of North Carolina at Chapel Hill; NIAID; Division of Viral Products, FDA; Beth Israel Deaconess Medical Center; University of Pennsylvania; Corporate Research Materials Lab, 3M Company; Infectious Disease Research Institute; BIOQUAL
Keywords: SARS-CoV-2, ferritin nanoparticle (RBD-scNP) vaccine, virus variants, immune response, primates
Summary of Study: Study demonstrates that scNP vaccines with SARS-CoV-2 spike or spike subunits confer potent protection in NHPs against WA-1, Beta and Delta variants, and that they induce neutralizing antibodies to all SARS-CoV-2 variants tested in vitro.
References: doi: 10.1101/2022.01.26.477915
Contact Info: Kevin Saunders: [email protected]; Barton Haynes: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.01.26.477915v2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Duke University School of Medicine; University of North Carolina at Chapel Hill; NIAID; Division of Viral Products, FDA; Beth Israel Deaconess Medical Center; University of Pennsylvania; Corporate Research Materials Lab, 3M Company; Infectious Disease Research Institute; BIOQUAL
Keywords: SARS-CoV-2, ferritin nanoparticle (RBD-scNP) vaccine, virus variants, immune response, primates
Summary of Study: Study demonstrates that scNP vaccines with SARS-CoV-2 spike or spike subunits confer potent protection in NHPs against WA-1, Beta and Delta variants, and that they induce neutralizing antibodies to all SARS-CoV-2 variants tested in vitro.
References: doi: 10.1101/2022.01.26.477915
Contact Info: Kevin Saunders: [email protected]; Barton Haynes: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.01.26.477915v2
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: MIT, Harvard Medical School, Vaccine Analytics and Formulation Center (Univ. of Kansas), Cummings School of Veterinary Medicine (Tufts Univ.), SpyBiotech Ltd., Bioqual, Bill & Melinda Gates Fdtn.
Keywords: SARS-CoV-2, protein subunit vaccine, manufacturing, preclinical testing, primates
Summary of Study: A modular protein subunit vaccine candidate elicits a strong immune response in cynomolgus macaques and protects against SARS-CoV-2 challenge. This vaccine candidate is currently being tested in clinical trials (ANZCTR Registration number ACTRN12620000817943).
References: PMID: 34282417 / doi: 10.1101/2021.07.13.452251
Contact Info: Dan Barouch: [email protected]; J. Christopher Love: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.07.13.452251v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: MIT, Harvard Medical School, Vaccine Analytics and Formulation Center (Univ. of Kansas), Cummings School of Veterinary Medicine (Tufts Univ.), SpyBiotech Ltd., Bioqual, Bill & Melinda Gates Fdtn.
Keywords: SARS-CoV-2, protein subunit vaccine, manufacturing, preclinical testing, primates
Summary of Study: A modular protein subunit vaccine candidate elicits a strong immune response in cynomolgus macaques and protects against SARS-CoV-2 challenge. This vaccine candidate is currently being tested in clinical trials (ANZCTR Registration number ACTRN12620000817943).
References: PMID: 34282417 / doi: 10.1101/2021.07.13.452251
Contact Info: Dan Barouch: [email protected]; J. Christopher Love: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.07.13.452251v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Harvard, MIT, Emory University School of Medicine, Yerkes National Primate Research Center and others
Keywords: SARS-CoV-2, adjuvanted soluble protein vaccine, binding and functional neutralization assays, serology, primates
Summary of Study: Antibodies induced by the AS03-adjuvanted preS dTM vaccine are sufficient to mediate protection against SARS-CoV-2 and support the evaluation of this vaccine in human clinical trials.
References: PMID: 33688652 / doi: 10.1101/2021.03.02.433390
Contact Info: Robert Seder: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.03.02.433390v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Harvard, MIT, Emory University School of Medicine, Yerkes National Primate Research Center and others
Keywords: SARS-CoV-2, adjuvanted soluble protein vaccine, binding and functional neutralization assays, serology, primates
Summary of Study: Antibodies induced by the AS03-adjuvanted preS dTM vaccine are sufficient to mediate protection against SARS-CoV-2 and support the evaluation of this vaccine in human clinical trials.
References: PMID: 33688652 / doi: 10.1101/2021.03.02.433390
Contact Info: Robert Seder: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.03.02.433390v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: BioNTech, Mainz, Germany
Keywords: SARS-CoV-2, BNT162b vaccine, primates
Summary of Study: Prime/boost vaccination of rhesus macaques with BNT162b candidates protect macaques from SARS-CoV-2 challenge. Both candidates are being evaluated in phase 1 trials in Germany and the US.
References: doi: https://doi.org/10.1101/2020.12.11.421008
Contact Info: Ugur Sahin: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.12.11.421008v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: BioNTech, Mainz, Germany
Keywords: SARS-CoV-2, BNT162b vaccine, primates
Summary of Study: Prime/boost vaccination of rhesus macaques with BNT162b candidates protect macaques from SARS-CoV-2 challenge. Both candidates are being evaluated in phase 1 trials in Germany and the US.
References: doi: https://doi.org/10.1101/2020.12.11.421008
Contact Info: Ugur Sahin: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.12.11.421008v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: University of Oxford
Keywords: SARS-CoV-2, protein nanoparticle vaccine, primates
Summary of Study: Ferrets and rhesus macaques were challenged with SARCS-CoV-2 to assess the potential for vaccine-enhanced disease (VED) in animals vaccinated with formaldehyde-inactivated SARS-CoV-2 formulated with Alhydrogel. This study revealed no evidence of enhanced disease in rhesus macaques.
References: doi: https://doi.org/10.1101/2020.12.21.423746
Contact Info: Andrew Gorringe: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.12.21.423746v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: University of Oxford
Keywords: SARS-CoV-2, protein nanoparticle vaccine, primates
Summary of Study: Ferrets and rhesus macaques were challenged with SARCS-CoV-2 to assess the potential for vaccine-enhanced disease (VED) in animals vaccinated with formaldehyde-inactivated SARS-CoV-2 formulated with Alhydrogel. This study revealed no evidence of enhanced disease in rhesus macaques.
References: doi: https://doi.org/10.1101/2020.12.21.423746
Contact Info: Andrew Gorringe: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.12.21.423746v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: NIAID; La Jolla Institute for Immunology; University of California; University of Capetown
Keywords: SARS-CoV-2, viral replication, pathogenesis. Immune response, primates
Summary of Study: SARS-CoV-2 infection leads to mild, focal lung inflammation, and type 1 IFN activated myeloid cells that mostly resolve prior to the influx of virus-specific effector T cells or antibody responses in rhesus macaques.
References: doi: 10.1101/2022.01.06.475282
Contact Info: Daniel Barber: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.01.06.475282v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: NIAID; La Jolla Institute for Immunology; University of California; University of Capetown
Keywords: SARS-CoV-2, viral replication, pathogenesis. Immune response, primates
Summary of Study: SARS-CoV-2 infection leads to mild, focal lung inflammation, and type 1 IFN activated myeloid cells that mostly resolve prior to the influx of virus-specific effector T cells or antibody responses in rhesus macaques.
References: doi: 10.1101/2022.01.06.475282
Contact Info: Daniel Barber: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2022.01.06.475282v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: NIAID, NHLBI, Emory NPRC, Bioqual, Inc.
Keywords: SARS-CoV-2, inflammation, clonal hematopoiesis, respiratory tract, primates
Summary of Study: Findings suggest potential pathophysiological differences with or without clonal hematopoiesis upon SARS-CoV-2 infection
References: doi: 10.1101/2023.01.01.522064
Contact Info: Tae-Hoon Shin: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.01.01.522064v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: NIAID, NHLBI, Emory NPRC, Bioqual, Inc.
Keywords: SARS-CoV-2, inflammation, clonal hematopoiesis, respiratory tract, primates
Summary of Study: Findings suggest potential pathophysiological differences with or without clonal hematopoiesis upon SARS-CoV-2 infection
References: doi: 10.1101/2023.01.01.522064
Contact Info: Tae-Hoon Shin: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2023.01.01.522064v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Ology Bioservices; Harvard Medical School; Vanderbilt University Medical Center; US Department of Defense; Logistics Management Institute; Washington University School of Medicine
Keywords: SARS-CoV-2, antibody treatment, spike protein, protection, primates
Summary of Study: Passive transfer of two neutralizing antibodies (COV2-2130 and COV2-2381) given prophylactically -- either individually or in combination (combination designated ADM03820) by intravenous or intramuscular route conferred virological protection in a NHP model of SARS-CoV-2 infection, and ADM03820 potently neutralized SARS-CoV-2 variants of concern in vitro.
References: doi: 10.1101/2021.09.27.462074
Contact Info: Dan Barouch: [email protected]; James Crowe: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.09.27.462074v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Ology Bioservices; Harvard Medical School; Vanderbilt University Medical Center; US Department of Defense; Logistics Management Institute; Washington University School of Medicine
Keywords: SARS-CoV-2, antibody treatment, spike protein, protection, primates
Summary of Study: Passive transfer of two neutralizing antibodies (COV2-2130 and COV2-2381) given prophylactically -- either individually or in combination (combination designated ADM03820) by intravenous or intramuscular route conferred virological protection in a NHP model of SARS-CoV-2 infection, and ADM03820 potently neutralized SARS-CoV-2 variants of concern in vitro.
References: doi: 10.1101/2021.09.27.462074
Contact Info: Dan Barouch: [email protected]; James Crowe: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.09.27.462074v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Jiangsu Rec-biotechnology Co Ltd, China; Chinese Academy of Medical Sciences; Wuhan University; Jiangsu Provincial Center for Disease Control and Prevention
Keywords: SARS-CoV-2, subunit vaccine, protective immunity, mice, primates
Summary of Study: Two-dose immunizations of ReCOV, a recombinant trimeric NTD and RBD two-component SARS-CoV-2 subunit vaccine adjuvanted with BFA03, provided complete protection against challenge with SARS-CoV-2 in hACE2 transgenic mice and rhesus macaques, without observable antibody-dependent enhancement of infection.
References: doi: 10.1101/2021.11.03.467182
Contact Info: Yong Liu: [email protected]; Feng-Cai Zhu: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.11.03.467182v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Jiangsu Rec-biotechnology Co Ltd, China; Chinese Academy of Medical Sciences; Wuhan University; Jiangsu Provincial Center for Disease Control and Prevention
Keywords: SARS-CoV-2, subunit vaccine, protective immunity, mice, primates
Summary of Study: Two-dose immunizations of ReCOV, a recombinant trimeric NTD and RBD two-component SARS-CoV-2 subunit vaccine adjuvanted with BFA03, provided complete protection against challenge with SARS-CoV-2 in hACE2 transgenic mice and rhesus macaques, without observable antibody-dependent enhancement of infection.
References: doi: 10.1101/2021.11.03.467182
Contact Info: Yong Liu: [email protected]; Feng-Cai Zhu: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.11.03.467182v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Tulane National Primate Research Center, Northwestern University, Duke University Medical Center, Tulane School of Medicine
Keywords: SARS-CoV-2, monoclonal antibodies, neutralization, mucosal viral challenge, immune response, primates
Summary of Study: A combination of two mAbs demonstrated that administration of these mAbs at a range of doses achieved near-complete protection from viral replication and disease even when challenge occurred 75 days after mAb administration.
References: doi: 10.1101/2021.05.26.445878
Contact Info: Chad Roy: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.05.26.445878v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Tulane National Primate Research Center, Northwestern University, Duke University Medical Center, Tulane School of Medicine
Keywords: SARS-CoV-2, monoclonal antibodies, neutralization, mucosal viral challenge, immune response, primates
Summary of Study: A combination of two mAbs demonstrated that administration of these mAbs at a range of doses achieved near-complete protection from viral replication and disease even when challenge occurred 75 days after mAb administration.
References: doi: 10.1101/2021.05.26.445878
Contact Info: Chad Roy: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.05.26.445878v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Washington Univ., Texas Biomedical Research Institute, and others
Keywords: SARS-CoV-2, spike ferritin nanoparticle vaccine, immune response, pathology, primates
Summary of Study: A SARS-CoV-2 spike protein ferritin nanoparticle vaccine, co-formulated with a liposomal adjuvant, elicits broad neutralizing antibody responses that exceed those observed for other major vaccines and rapidly protects against respiratory infection and disease in the upper and lower airways and lung tissue of NHPs.
References: PMID: 33791694 / doi: 10.1101/2021.03.24.436523
Contact Info: Kayvon Modjarrad: [email protected]; Michael Joyce: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.03.24.436523v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Walter Reed Army Institute of Research; Washington Univ., Texas Biomedical Research Institute, and others
Keywords: SARS-CoV-2, spike ferritin nanoparticle vaccine, immune response, pathology, primates
Summary of Study: A SARS-CoV-2 spike protein ferritin nanoparticle vaccine, co-formulated with a liposomal adjuvant, elicits broad neutralizing antibody responses that exceed those observed for other major vaccines and rapidly protects against respiratory infection and disease in the upper and lower airways and lung tissue of NHPs.
References: PMID: 33791694 / doi: 10.1101/2021.03.24.436523
Contact Info: Kayvon Modjarrad: [email protected]; Michael Joyce: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.03.24.436523v1
Coronavirus Investigated: SARS-CoV-2
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: University of Tokyo, Daichi Sankyo Col, Shiga University of Medical science, and others
Keywords: SARS-CoV-2, lipid nanoparticle-based mRNA vaccine candidate, immunogenicity, primates
Summary of Study: Macaques administered with LNP-mRNA targeting RBD acquired significantly high levels of protective IgG specific to SARS-CoV-2 in mucosal swab samples from conjunctiva, oral cavity, nasal cavity, trachea, bronchus, and rectum.
References: doi: 10.1101/2021.03.04.433852
Contact Info: Ken Ishii: [email protected]; Yoshihiro Kawaoka: [email protected]; Fumihiko Takeshita: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.03.04.433852v1
NHP Species:
Year Published:
Study Type/Review: vaccine
NPRC/Institute: University of Tokyo, Daichi Sankyo Col, Shiga University of Medical science, and others
Keywords: SARS-CoV-2, lipid nanoparticle-based mRNA vaccine candidate, immunogenicity, primates
Summary of Study: Macaques administered with LNP-mRNA targeting RBD acquired significantly high levels of protective IgG specific to SARS-CoV-2 in mucosal swab samples from conjunctiva, oral cavity, nasal cavity, trachea, bronchus, and rectum.
References: doi: 10.1101/2021.03.04.433852
Contact Info: Ken Ishii: [email protected]; Yoshihiro Kawaoka: [email protected]; Fumihiko Takeshita: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.03.04.433852v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Rocky Mountain Laboratories/NIAID/NIH, University of Colorado School of Medicine
Keywords: SARS-CoV-2, T cells, immune response, pathology, primates
Summary of Study: T-cells play a role in the recovery of rhesus macaques from acute SARS-CoV-2 infections, although their depletion does not induce severe disease, and T cells do not account for the natural resistance of rhesus macaques to severed COVID-19. Neither primed CD4+ or CD8+ T cells appeared critical for immunoglobulin class switching, the development of immunological memory or protection from a second infection.
References: PMID: 33821272 / doi: 10.1101/2021.04.02.438262
Contact Info: Kim Hasenkrug: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.04.02.438262v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review:
NPRC/Institute: Rocky Mountain Laboratories/NIAID/NIH, University of Colorado School of Medicine
Keywords: SARS-CoV-2, T cells, immune response, pathology, primates
Summary of Study: T-cells play a role in the recovery of rhesus macaques from acute SARS-CoV-2 infections, although their depletion does not induce severe disease, and T cells do not account for the natural resistance of rhesus macaques to severed COVID-19. Neither primed CD4+ or CD8+ T cells appeared critical for immunoglobulin class switching, the development of immunological memory or protection from a second infection.
References: PMID: 33821272 / doi: 10.1101/2021.04.02.438262
Contact Info: Kim Hasenkrug: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.04.02.438262v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques, pigtail macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: University of Washington, UNC, Chapel Hill and others
Keywords: SARS-CoV-2, multivalent receptor-binding domain nanoparticle vaccine, immune response, variants, mice and primates
Summary of Study: Mosaic and cocktail sarbecovirus RBD-NPs elicit broad and protective Ab responses against heterologous sarbecovirus challenge, which could represent the next generation of pan-sarbecovirus vaccines.
References: PMID: 33758839 / doi: 10.1101/2021.03.15.435528
Contact Info: Neil King: [email protected]; David Veesler: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.03.15.435528v1
NHP Species: rhesus macaques, pigtail macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: University of Washington, UNC, Chapel Hill and others
Keywords: SARS-CoV-2, multivalent receptor-binding domain nanoparticle vaccine, immune response, variants, mice and primates
Summary of Study: Mosaic and cocktail sarbecovirus RBD-NPs elicit broad and protective Ab responses against heterologous sarbecovirus challenge, which could represent the next generation of pan-sarbecovirus vaccines.
References: PMID: 33758839 / doi: 10.1101/2021.03.15.435528
Contact Info: Neil King: [email protected]; David Veesler: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.03.15.435528v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Janssen Vaccines and Prevention, The Netherlands
Keywords: SARS-CoV-2, adenovirus-vectored vaccine, neutralization potency, aged animals, primates
Summary of Study: The Janssen Ad26.COV2.S vaccine candidate is currently the only one evaluated as a single dose vaccination regimen in Phase 3 clinical studies. This study showed that a second vaccine dose (administered 8 weeks post the first immunization) induced a significant increase in antigen-specific binding and neutralizing antibody responses in both adult and aged rhesus macaques as compared to a single dose. These data support the initiation of a two-dose Ad26.COV2.S regimen in Phase 3 clinical trial in adults and elderly.
References: doi: https://doi.org/10.1101/2020.11.17.368258
Contact Info: Roland Zahn: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.11.17.368258v1
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Janssen Vaccines and Prevention, The Netherlands
Keywords: SARS-CoV-2, adenovirus-vectored vaccine, neutralization potency, aged animals, primates
Summary of Study: The Janssen Ad26.COV2.S vaccine candidate is currently the only one evaluated as a single dose vaccination regimen in Phase 3 clinical studies. This study showed that a second vaccine dose (administered 8 weeks post the first immunization) induced a significant increase in antigen-specific binding and neutralizing antibody responses in both adult and aged rhesus macaques as compared to a single dose. These data support the initiation of a two-dose Ad26.COV2.S regimen in Phase 3 clinical trial in adults and elderly.
References: doi: https://doi.org/10.1101/2020.11.17.368258
Contact Info: Roland Zahn: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2020.11.17.368258v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: african green monkeys
Year Published:
Study Type/Review: vaccine
NPRC/Institute: City of Hope National Medical Center; Bioqual
Keywords: SARS-CoV-2, vaccine efficacy, humoral and cellular immune responses, primates
Summary of Study: COH04S1, a synthetic multiantigen Modified Vaccinia Ankara-based SARS-CoV-2 vaccine that co-expresses spike and nucleocapsid antigens, demonstrated protection in animal models through different vaccination routes and dose regimens, complementing ongoing investigation of this multiantigen SARS-CoV-2 vaccine in clinical trials.
References: PMID: 34545366 / doi: 10.1101/2021.09.15.460487
Contact Info: Felix Wussow: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.09.15.460487v1
NHP Species: african green monkeys
Year Published:
Study Type/Review: vaccine
NPRC/Institute: City of Hope National Medical Center; Bioqual
Keywords: SARS-CoV-2, vaccine efficacy, humoral and cellular immune responses, primates
Summary of Study: COH04S1, a synthetic multiantigen Modified Vaccinia Ankara-based SARS-CoV-2 vaccine that co-expresses spike and nucleocapsid antigens, demonstrated protection in animal models through different vaccination routes and dose regimens, complementing ongoing investigation of this multiantigen SARS-CoV-2 vaccine in clinical trials.
References: PMID: 34545366 / doi: 10.1101/2021.09.15.460487
Contact Info: Felix Wussow: [email protected]
URL: https://www.biorxiv.org/content/10.1101/2021.09.15.460487v1
Coronavirus Investigated: SARS-CoV-2
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Ragon Institute of MGH, MIT and Harvard
Keywords: SARS-CoV-2, humoral immune response, recombinant full-length spike glycoprotein (NVX-CoV2373), primates
Summary of Study: Deep profiling of the humoral immune response in a cohort of non-human primates immunized with one or two doses of 5 or 25 ug of a stabilized recombinant full-length SARS-CoV-2 spike glycoprotein with 50 ug Matrix-M adjuvant suggests that a single dose of may prevent disease, but that two doses may be essential to block further transmission of SARS-CoV-2 and emerging variants.
References: PMID: 33619473 / doi: 10.21203/rs.3.rs-200342/v1
Contact Info: Galit Alter: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899467/pdf/nihpp-rs200342v1.pdf
NHP Species: rhesus macaques
Year Published:
Study Type/Review: vaccine
NPRC/Institute: Ragon Institute of MGH, MIT and Harvard
Keywords: SARS-CoV-2, humoral immune response, recombinant full-length spike glycoprotein (NVX-CoV2373), primates
Summary of Study: Deep profiling of the humoral immune response in a cohort of non-human primates immunized with one or two doses of 5 or 25 ug of a stabilized recombinant full-length SARS-CoV-2 spike glycoprotein with 50 ug Matrix-M adjuvant suggests that a single dose of may prevent disease, but that two doses may be essential to block further transmission of SARS-CoV-2 and emerging variants.
References: PMID: 33619473 / doi: 10.21203/rs.3.rs-200342/v1
Contact Info: Galit Alter: [email protected]
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899467/pdf/nihpp-rs200342v1.pdf