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Parent grant number: P51OD011104
PI: Hamm, L Lee
Title of Parent Project: Tulane National Primate Research Center
Title of Administrative Supplement: Post-Acute COVID Sequelae in African Green Monkeys
Summary of the Supplement
This supplement establishes a model in African green monkeys for the investigation of long-term effects of SARS-CoV-2 infection. For the proposed studies, the team will perform clinical, biologic, immunologic, virologic, behavioral, pulmonary and telemetric studies at baseline and during SARS-CoV-2 infection in African green monkeys. The PIs will evaluate the status of active and transmissible infection to determine timepoints for the safe transfer of animals to a ABSL-2 environment that will facilitate studies of the longer-term consequences of SARS-CoV-2 infection. In addition, animals will also be administered the Pfizer vaccine to determine its potential as a therapeutic to modulate acute and post-acute infection phases.
Source of Supplemental Funding: ORIP
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Parent grant number: P51OD011132
PI: Lewin, Jonathan S
Title of Parent Project: Support of Yerkes National Primate Research Center
Title of Administrative Supplement: Developing an NHP model for understanding the biological causes of long COVID-19 pathogenesis
Summary of the Supplement
The main goal of this project is to establish a rhesus macaque animal model for studying Post-Acute Sequelae of COVID-19. The PI will establish biosafety guidelines and procedures for Post-Acute Sequelae studies in rhesus macaques and will characterize neurological and behavioral findings, which will allow the transfer of convalescent rhesus macaques from ABSL-3 to ABLS-2 facilities. The team will also elucidate the underlying biological causes of Post-Acute Sequelae by performing a battery of molecular, cellular, immune, and physiological assays for pulmonary and cardiovascular functions, as well as behavioral assays for cognitive function. The completion of this project will provide safety guidelines to facilitate the neurological and behavioral studies that are critical for understanding the mechanisms underlying Post Acute Sequelae.
Source of Supplemental Funding: ORIP
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Parent grant number: P51OD011092
PI: Barr-Gillespie, Peter G
Title of Parent Project: Support for National Primate Research Center
Title of Administrative Supplement: Novel Therapy for SARS-CoV-2 Virus Infection and Pathogenesis by Aerosol
Delivery of Monoclonal Antibodies
Summary of the Supplement
The purpose of this study is to evaluate neutralizing monoclonal antibodies that possess high specificity and potency as a post-exposure prophylaxis for SARS-CoV-2 in rhesus macaques by using a novel aerosol delivery system. The potential benefits of inhaled monoclonal antibodies for patients are the following: (1) this treatment can be administered at home, (2) a smaller amount of material would be required for administration compared to intravenous delivery, and (3) risks associated with intravenous delivery such as infusion reactions, acute anaphylaxis, and serum sickness would be avoided.
Source of Supplemental Funding: ORIP
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Parent grant number: P51OD010425
PI: Sullivan, Sean D
Title of Parent Project: Washington National Primate Research Center
Title of Administrative Supplement: Impact of pre-existing SARS-CoV-2 immunity on vaccination against new variants
Summary of the Supplement
The objective of this project is to test the impact of pre-existing SARS-CoV-2 immunity with vaccination against new virus variants. Pre-immunity to an earlier variant of SARS-CoV-2 may enable the new vaccines to induce an even broader group of antibody responses against different variants. This pilot study will boost the pre-exesting immunity of the pigtail macaques to the original D614G variant with a self-amplifying replicon RNA (or “repRNA”) vaccine.
Source of Supplemental Funding: ORIP
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Parent grant number: P51OD011107
PI: Mohapatra, Prasant
Title of Parent Project: California National Primate Research Center
Title of Administrative Supplement: California National Primate Research Center
Summary of the Supplement
The goal of this proposal is to understand Post Acute Sequelae COVID by establishing a rhesus macaque animal model with the syndrome and using this model to dissect immunological and virological determinants of PASC. The investigators also aim to determine the feasibility of transitioning SARS-CoV2 infected rhesus macaques from ABSL-3 to ABSL-2 by delineating the kinetics of infectious and non-infectious viral shedding in the respiratory and GI tracts as well as generating preliminary data on the fundamental pathobiology of Post Acute Sequelae COVID. Vaccination followed by monitoring of immune activation/dysregulation, cardiovascular function, and lung function will be performed to understand the impact of vaccination on alleviation of Post Acute Sequelae symptoms.
Source of Supplemental Funding: ORIP
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Parent grant number: P40OD024628
PI: Simmons, Joe H
Title of Parent Project: Specific Pathogen Free Baboon Research Resource (SPFBRR)
Title of Administrative Supplement: Specific Pathogen Free Baboon Research Resource (SPFBRR) -
Administrative Supplement
Summary of the Supplement
This project proposes to develop a novel vaccine platform that employs engineered exosomes. Investigators will test the efficacy of exosomes in eliciting B- and T cell immunity as well as long term antibody production in baboons. The project will also expand the capabilities of the Specific Pathogen Free Baboon Research Resource as a source of an alternate NHP model along with offering a platform and related services for testing vaccines and other therapeutics.
Source of Supplemental Funding: ORIP
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Parent grant number: P51OD011133
PI: Schlesinger, Larry S
Title of Parent Project: The Southwest National Primate Research Center
Title of Administrative Supplement: To better understand impact of long-term SARS-CoV-2 infection in a NHP (baboon) model
Summary of the Supplement
The goal of this project is to characterize the long-terms health effects of COVID-19 infection in baboons and establish it as an animal model for studying Post Acute Sequelae of COVID-19. Various parameters relevant to long-term health effects will be measured, including viral RNA in plasma, urine, and lymphoid tissue, immune responses, lung function, chest radiograph, lung function, and electrocardiogram. This project will validate baboons as an animal for studying Post Acute Sequelae.
Source of Supplemental Funding: ORIP
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Parent grant number: P51OD011092
PI: Barr-Gillespie, Peter G
Title of Parent Project: Support for National Primate Research Center
Title of Administrative Supplement: Corral 9 renovation to support SPF NHP breeding
Summary of the Supplement
The project will expand existing housing with a newly designed half-acre corral tied to existing infrastructure that will provide animals with varied enrichment options and include an introduction area to facilitate animal reintegration. The proposed corral redesign will increase breeding capacity of SPF rhesus macaques for research to respond to SARS-CoV-2 and future emerging pathogens.
Source of Supplemental Funding: NIAID
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Parent grant number: P51OD011133
PI: Schlesinger, Larry S
Title of Parent Project: The Southwest National Primate Research Center - Overall
Title of Administrative Supplement: Increasing the size of the specific pathogen free Indian rhesus macaques colony at the Southwest National Primate Research Center for AIDS, COVID-19 and other infectious diseases research
Summary of the Supplement
The goal of this project is to renovate a building to increase rhesus macaque breeding and holding space in support of SARS-CoV-2 research and other global pandemic emergencies.
Source of Supplemental Funding: NIAID
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Parent grant number: P51OD011104
PI: Hamm, L Lee
Title of Parent Project: Tulane National Primate Research Center
Title of Administrative Supplement: TNPRC Breeding Colony Expansion in Support of COVID-19 Research
Summary of the Supplement
The project will add an enclosure unit to house additional Specific Pathogen Free rhesus macaques and provide financial support for population expansion. The proposed enclosure has been designed to maximize capacity and flexibility with novel and proven environmental enhancement components. The improvement will expand the Specific Pathogen Free rhesus macaque research infrastructure to assure these colonies are sustainable and able to provide well-characterized research models into the future, including providing animals for COVID-19 and pandemic focused research.
Source of Supplemental Funding: NIAID
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Parent grant number: P51OD011107
PI: Mohapatra, Prasant
Title of Parent Project: California National Primate Research Center
Title of Administrative Supplement: California National Primate Research Center
Summary of the Supplement
This is an administrative supplement from the California National Primate Research Center (CNPRC). This supplement will support expand breeding of rhesus macaques at CNPRC through alteration and renovations (A&R) and an increased breeding program to produce more infants. The A&R portion consists of repairs to half-acre outdoor corrals, so they are functional. Breeding colony expansion includes acquiring young rhesus macaques from the Caribbean Primate Research Center (CPRC) for integration into the breeding colony. Support for per diem of the expanded breeding group as well as additional staff to provide for the animal care, colony management, and veterinary care needs is included. The project will assist in providing animals for COVID-19 and pandemic focused research.
Source of Supplemental Funding: NIAID
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Parent grant number: P51OD011107
PI: Lewin, Jonathan S
Title of Parent Project: Support of Yerkes National Primate Research Center
Title of Administrative Supplement: Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesis
Summary of the Supplement
This supplement will conduct a study using rhesus macaques to evaluate the effect of type I interferon antagonist on COVID-19 disease severity. A wide range of viral, molecular, cellular, immunological, and clinical endpoints will be collected from the animals at serial timepoints. Many of these samples will be investigated histologically and/or via molecular and other approaches by two different labs to test and develop NPRC COVID-19 standard operating procedures and assess reproducibility. Samples will also be bio-banked as resources for future use by other researchers.
Source of Supplemental Funding: NIAID
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Parent grant number: P51OD011107
PI: Ackerman, Steven A.
Title of Parent Project: Wisconsin National Primate Research Center Support
Title of Administrative Supplement: Administrative Supplement: Wisconsin National Primate Research Center Support: Conversion to ABSL3 Facilities in the WNPRC Quarantine Unit
Summary of the Supplement
This administrative supplement supports establishment of a functional ABSL-3 facility. Funds cover installation of two BioBubble enclosures that meet ABSL-3 requirements and have the capability to support basic SARS-CoV-2 challenge studies with essential endpoints.
Source of Supplemental Funding: NIAID
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Parent grant number: P51OD011107
PI: Martinez, Melween I.
Title of Parent Project: Caribbean Primate Research Center
Title of Administrative Supplement: Contribute to the breeding expansion and to the genetic diversity at California NPRC
Summary of the Supplement
This administrative supplement supports the transfer of Specific Pathogen Free rhesus macaques from the conventional colony of the Caribbean Primate Research Center to the California National Primate Research Center to expand breeding capabilities and the diversity of the genetic pool at the California National Primate Research Center. This expansion will assist COVID and pandemic focused research.
Source of Supplemental Funding: NIAID
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Parent grant number: P51OD011106
PI: Ackerman, Steven A
Title of Parent Project: Wisconsin National Primate Research Center Support
Title of Administrative Supplement: Wisconsin National Primate Research Center Support
Summary of the Supplement
The Wisconsin National Primate Center at the University of Wisconsin-Madison will renovate quarantine suites into ABSL3-space though purchase and installation of two ready-to-use biobubble containment enclosures as well as associated equipment (i.e., imaging, molecular biology, diagnostic, necropsy, etc.) to support SARS-CoV-2 challenge studies.
Source of Supplemental Funding: NIAID
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Parent grant number: P51OD011107
PI: Prasant Mohapatra
Title of Parent Project: California National Primate Research Center
Title of Administrative Supplement: California National Primate Research Center
Summary of the Supplement
The California National Primate Research Center at the University of California at Davis will conduct an Operation Warp Speed therapeutic study designed to understand what neutralizing antibody titer is needed to ameliorate disease in an early postexposure SARS-CoV-2 nonhuman primate model, which represents people who have mild disease/outpatients. This information is needed to inform therapeutic human clinical trials that are currently being planned and will lay the foundation for future studies for testing efficacy later in infection, representing patients who are hospitalized with severe disease.
Source of Supplemental Funding: NIAID
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Parent grant number: P51 OD011132
PI: Lewin, Jonathan S
Title of Parent Project: Support of Yerkes National Primate Research Center
Title of Administrative Supplement: Support of Yerkes National Primate Research Center
Summary of the Supplement
The Yerkes National Primate Research Center at Emory University will conduct multiple facility and equipment enhancements in support of COVID-19 research in the ABSL-3 and BSL-3 facilities. The proposed equipment for purchase and use will provide optimal support for a large base of NIH-funded COVID-19 research projects at the Yerkes NPRC, ultimately contributing to the development of safe and effective vaccines and therapeutics for COVID-19.
Source of Supplemental Funding: NIAID
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Parent grant number: P51OD011107
PI: MOHAPATRA, PRASANT
Title of Parent Project: California National Primate Research Center
Title of Administrative Supplement: California National Primate Research Center
Summary of the Supplement
The California National Primate Research Center at the University of California at Davis will purchase steel overhead structures for two half-acre field corrals which will support increased breeding to ensure a continued pipeline of rhesus macaques for COVID-19 research as well as equipment for an ABSL-3 suite to support infectious disease research on SARS-CoV-2.
Source of Supplemental Funding: NIAID
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Parent grant number: P51 OD011133
PI: Schlesinger, Larry S.
Title of Parent Project: The Southwest National Primate Research Center - Overall
Title of Administrative Supplement: Significant expansion of the SNPRC ABSL3 capability in the wake of COVID-19
Summary of the Supplement
The Southwest National Primate Research Center at the Texas Biomedical Research Institute will renovate and equip a recently decommissioned ABSL3 facility, thus increasing ABSL3 capacity for COVID-19 research.
Source of Supplemental Funding: NIAID
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Parent grant number: P51OD011104
PI: Hamm, L Lee
Title of Parent Project: Tulane National Primate Research Center
Title of Administrative Supplement: Improving Research Resources at the TNPRC to Support COVID-19 Research
Summary of the Supplement
The Tulane National Primate Research Center at the Tulane University will enrich research resources for COVID-19 research through two specific resource improvements: expansion of specific pathogen free (SPF) rhesus macaque breeding colony housing infrastructure and the purchase of high-end laboratory instrumentation for BSL-2/3 laboratory space to support COVID-19 studies.
Source of Supplemental Funding: NIAID
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Parent grant number: U42OD010442
PI: Deepak Kushal
Title of Parent Project: Establishment of a SPF Rhesus Macaque Colony
Title of Administrative Supplement: PCR and antibody screening for SARS-CoV-2 in the SNPRC rhesus macaque colony
Summary of the Supplement
The purpose of this administrative supplement is to screen the entire SNPRC U42 rhesus macaque colony for both SARS-CoV-2 virus and antibodies using established approaches and to develop faster and less expensive in-house tests for SARS-CoV-2. The methods and results of this work at SNPRC will be disseminated to other primate centers maintaining SPF macaque breeding colonies. The Center will implement and develop methods for SARS-CoV-2 surveillance in the SNPRC SPF rhesus macaque breeding colony, allowing the detection and mitigation of a SARS-CoV-2 outbreak in the colony.
Source of Supplemental Funding: ORIP
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Parent grant number: U42OD011123
PI: Charlotte Hotchkiss (CONTACT);
Sally Thompson-Iritani
Title of Parent Project: WaNPRC Macaca nemestrina SPF Breeding Colony
Title of Administrative Supplement: Development of a COVID-19 Testing Program for SPF M. nemestrina
Summary of the Supplement
The purpose of this administrative supplement is to ensure that the current COVID-19 pandemic does not negatively affect the health of pigtail macaques within the SPF breeding colony, affect the health of individuals who work with these animals, or interfere with the usefulness of pigtail macaques as models for HIV/AIDS research or for COVID-19 research with surplus animals. The Center will develop and validate virus and antibody tests for macaque coronaviruses, including SARS-CoV-2 and seasonal coronaviruses in pigtail macaques; determine the most efficient and accurate sampling and testing methods; and screen animals within the SPF pigtail macaque colony . The methods and results of this work at WaNPRC will be disseminated to other primate centers maintaining SPF macaque breeding colonies.
Source of Supplemental Funding: ORIP
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Parent grant number: U42OD010990-20W1
PI: Jeffrey Roberts
Title of Parent Project: Production of Pedigreed SPF Rhesus Macaques
Title of Administrative Supplement: California National Primate Research Center
Summary of the Supplement
The purpose of this administrative supplement is to expand the viral agents excluded for level 1 and 2 SPF macaque colonies to include SARS-CoV-2 as SPF NHP macaque populations are at risk for COVID-19. The Center will implement and develop methods for SARS-CoV-2 surveillance in the CNPRC SPF rhesus macaque breeding colony, allowing the detection and mitigation of a SARS-CoV-2 outbreak in the colony. The methods and results of the work will be disseminated to other primate centers maintaining SPF macaque breeding colonies through the NPRC Pathogen Detection Working Group and via ongoing interactions with ORIP program staff.
Source of Supplemental Funding: ORIP
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Parent grant number: U42OD011023
PI: Joyce Kimberly Cohen
Title of Parent Project: "Maintenance of the SPF Breeding Colonies at Yerkes National Primate Research Center"
Title of Administrative Supplement: "Maintenance of the SPF Breeding Colonies at Yerkes National Primate Research Center"
Summary of the Supplement
"The purpose of this administrative supplement is to add screening for evidence of SARS-CoV-2 infection by developing and implementing molecular and serologic methods for detecting SARS-CoV-2 infection and immunity in the SPF rhesus macaque colony at the Yerkes NPRC. The proposal will also add genetic screening which will define and determine the frequency of distinct ACE2 coding alleles within the colony. The methods and results of this work at Yerkes will be disseminated to other primate centers housing SPF macaque colonies."
Source of Supplemental Funding: ORIP
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Parent grant number: P40OD028116
PI: Diogo Magnani (contact); Kathleen Engelman
Title of Parent Project: Nonhuman Primate Antibody Resource for Immune Cell Depletion
Title of Administrative Supplement: Nonhuman Primate Antibody Resource for Immune Cell Depletion
Summary of the Supplement
"The purpose of this administrative supplement is to create safe recombinant reference macaque immunoglobulin standards to facilitate the development and validation of reliable assays for the detection of pathogenic coronaviruses and antiviral antibodies in nonhuman primate (NHP) animal models of COVID. Specifically, this supplement will fund the generation of the following reagents: recombinant coronavirus-reactive rhesus monoclonal IgGs and NHP serum reference standards. These macaque reference antibody reagents will improve the performance and comparability of antibody-based assays for NHP models by facilitating serum assay development, proficiency training, and inter-laboratory performance comparisons at NHP centers and laboratories.
Source of Supplemental Funding: ORIP
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Parent grant number: R24OD021324-05
PI: Betsy M Ferguson
Title of Parent Project: Genomic sequencing to establish a macaque genotype and phenotype research resource
Title of Administrative Supplement: Genomic and Immunogenetic Resource to Support SRA-CoV-2/COVID-19 Nonhuman Primate Research
Summary of the Supplement
"The purpose of this administrative supplement is to extend a centralized resource (mGAP) to include the generation, analysis and dissemination of genomic sequence variants from nonhuman primates used in SARS-CoV-2 studies (the new SARS-CoV-2 portal will be located within the mGAP website). The proposed work, in conjunction with the mGAP resource, will support studies to understand how host genetic variation influences vaccine and treatment efficacy."
Source of Supplemental Funding: ORIP
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